KR101802313B1

KR101802313B1 - Manufacturing method of composition for moisturizing the skin

Info

Publication number: KR101802313B1
Application number: KR1020150166988A
Authority: KR
Inventors: 이장렬; 김준영; 정향화
Original assignee: 주식회사 에스티에스연구소
Priority date: 2015-11-27
Filing date: 2015-11-27
Publication date: 2017-12-28
Also published as: KR20170061870A

Abstract

In the present invention, 30 g of a triple copolymer (HO (CH ₂ CH ₂ O) ₂ O (CH ₂ CH (CH ₃ ) O) ₇₀ (CH ₂ CH ₂ O) ₂ OH, 848 g of distilled water, 56 g of hydrochloric acid, Stirring the first solution mixed with 64 g of TEOS as a precursor for 20 minutes (first step); Stirring the first solution stirred in the first step for 24 hours while heating to 40 캜 (second step); Stirring the first solution stirred in the second step for 24 hours while heating to 100 캜 (step 3); The first solution stirred in the third step is filtered, and the separated solid mixture is washed with distilled water three times, dried at 80 ° C. and then calcined at 550 ° C. for 3 hours to obtain mesoporous silica powder Step 4); Dissolving a mixture of wax, jojoba oil, and a surfactant in a bath at 60 캜 to prepare a second solution (fifth step); Dispersing the mesoporous silica powder obtained in the fourth step in ethanol, and mixing water and propylene glycol to prepare a third solution (step 6); Hyaluronic acid and sodium lactate are sequentially added to the third solution prepared in the sixth step and 0.5 to 10 parts by weight of polypropylene glycol having a molecular weight of 1000 or less is added to the third solution (Step 7); Further adding PHMB (polyhexamethylene biguanide) to the third solution of the seventh step and aging at a temperature of 30 to 60 DEG C for 6 to 18 hours (step 8); And mixing and stirring the second solution prepared in the fifth step with the third solution obtained in the eighth step (step 9).

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for skin moisturizing,

The present invention relates to a composition for moisturizing the skin contained in cosmetics used for moisturizing the skin and a method for producing the same.

Generally, in winter, the air is dried and the skin becomes dry.

If such dry skin is left untreated, the possibility of various skin diseases such as atopic dermatitis, juvenile, dry skin, chronic eczema is increased.

Recently, skin moisturizing agents have been increasingly used to prevent skin dryness.

That is, it is important to use a skin moisturizing agent that can maintain the moisture of the skin in order to effectively prevent various skin diseases and maintain a healthy skin.

However, oil such as fatty acid triglycerides and squalene that can form an oil seal with glycerol, which is commonly used as a skin moisturizer, can temporarily retain moisture of the skin, but can not maintain moisture of the skin for a long time There is a problem.

On the other hand, the technology to be a background of the present invention is disclosed in Korean Patent Publication No. 10-2008-0088735.

The present invention has been made to solve the above-mentioned problems, and provides a composition for moisturizing the skin and a method for producing the composition, which can maintain the moisturizing effect of the skin for a long time.

Composition production method for moisturizing of the present invention, a triple copolymer _{(HO (CH 2 CH 2 O} ) 2 0 (CH 2 CH (CH 3) O) 7 0 (CH 2 CH 2 O) 2 0H) 30g, deionized water 84 g of hydrochloric acid, 56 g of hydrochloric acid, and 64 g of TEOS as a silica precursor was stirred for 20 minutes (first step); Stirring the first solution stirred in the first step for 24 hours while heating to 40 캜 (second step); Stirring the first solution stirred in the second step for 24 hours while heating to 100 캜 (step 3); The first solution stirred in the third step is filtered, and the separated solid mixture is washed with distilled water three times, dried at 80 ° C. and then calcined at 550 ° C. for 3 hours to obtain mesoporous silica powder Step 4); Dissolving a mixture of wax, jojoba oil, and a surfactant in a bath at 60 캜 to prepare a second solution (fifth step); Dispersing the mesoporous silica powder obtained in the fourth step in ethanol, and mixing water and propylene glycol to prepare a third solution (step 6); Hyaluronic acid and sodium lactate are sequentially added to the third solution prepared in the sixth step and 0.5 to 10 parts by weight of polypropylene glycol having a molecular weight of 1000 or less is added to the third solution (Step 7); Further adding PHMB (polyhexamethylene biguanide) to the third solution of the seventh step and aging at a temperature of 30 to 60 DEG C for 6 to 18 hours (step 8); And mixing and stirring the second solution prepared in the fifth step and the third solution obtained in the eighth step (step 9).
The size of the pores of the mesoporous silica may be 2 nm to 30 nm.
The solution stirred in the ninth step may be in an emulsion state.

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According to the composition for moisturizing the skin according to the present invention, the moisturizing effect of the moisturizing effect can be maintained for a long time by delaying the time for the moisturizing substance to be expressed from the nanoporous substance.

1 is a flow chart of a method of manufacturing a skin moisturizing composition according to an embodiment of the present invention.

Hereinafter, some embodiments of the present invention will be described in detail.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the following description of the embodiments of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the understanding why the present invention is not intended to be a complete disclosure.

In describing the components of the embodiment of the present invention, terms such as first, second, A, B, (a), and (b) may be used. These terms are intended to distinguish the constituent elements from other constituent elements, and the terms do not limit the nature, order or order of the constituent elements.

Hereinafter, a composition for skin moisturizing according to an embodiment of the present invention will be described.

The skin moisturizing composition of the present invention includes nanoporous substances, moisturizing substances and antibacterial substances.

The skin moisturizing composition may be prepared by immersing the above-mentioned nano-porous material in an amount of 0.01 to 15 parts by weight, the aforementioned moisturizing material in an amount of 15 to 55 parts by weight, and the above-mentioned antibacterial material in an amount of 0.5 to 5.0 parts by weight.

A plurality of pores may be formed in the nanoporous material.

The size of the pores formed in the nanoporous material may be 2 nm to 500 nm.

When the size of the pores formed in the nanoporous material is less than 2 nm, it is difficult to immerse the humectant and the antibacterial material in the nanoporous material. When the size of the pores formed in the nanoporous material is larger than 500 nm, There is a problem in that the sustainability of the system is poor.

More specifically, the nanoporous material may be a mesoporous material having a pore size ranging from 2 nm to 100 nm, or a macroporous material having a pore size ranging from 100 nm to 500 nm.

When the liquid moisturizing substance and the antibacterial substance are immersed in the mesoporous substance and the macroporous substance, the moisturizing substance and the antibacterial substance can be deposited in the pores formed in the mesoporous substance and the macroporous substance.

On the other hand, the mesoporous material may be mesoporous silica having a pore size of 2 nm to 30 nm.

More specifically, the mesoporous silica may be composed of at least one selected from the group consisting of a first mesoporous molecular sieve, a second mesopore molecular sieve, and a third mesopore molecular sieve.

Here, the first mesopore molecular sieve, the second mesopore molecular sieve and the third mesopore molecular sieve have pores each having a size of 2 nm to 10 nm.

The first mesopore molecular sieve, the second mesopore molecular sieve, and the third mesopore molecular sieve may be prepared by mixing silica anions such as TEOS, TMOS, Ludox, Carbosil, and sodium silicate, which are dissolved in an aqueous solution, (sol-gel process of hydrolysis / condensation) of the silica source in the hydrothermal reaction process, while forming a complex structure (suplamolecular assembly) by bonding to the micelle shell.

Wherein the first mesoporous molecular sieve is arranged in one dimension and forms regular hexagonal pores, the second mesoporous molecular sieve is three-dimensionally arranged to form cubic pores, The pore molecular sieve is formed into a lamella structure.

And the first mesopore molecular sieve is a silica mesoporous molecular sieve, the pores of the first mesopore molecular sieve are uniform in size and large and can quickly diffuse and deposit the moisturizing material and the antimicrobial material.

On the other hand, the mesoporous material is not limited to mesoporous silica. Mesoporous titania, mesoporous zirconia, mesoporous clay, and the like can also be used.

Macroporous silica, macroporous titania, macroporous clay, etc. may be used as the macroporous material.

The moisturizing material may be deposited in pores formed in the nanoporous material.

Such a moisturizing substance is a substance capable of increasing the moisture content of the skin, and may be selected from the group consisting of glycerin, hyaluronic acid, propylene glycol, coconut butter, olive oil, lactic acid (in the form of sodium lactate) And may include any one or more selected from the group consisting of beta-glucan, fatty acid triglyceride, squalene, petrolatum oil, lanolin, jojoba oil, mineral oil, and ceramide.

The antimicrobial material may include at least one selected from the group consisting of nanosilver, nano zinc oxide, nano-titania, nano-zirconia, grapefruit extract, and polyhexamethylene biguanide (PHMB) or polyhexamethylene monoguanide (PHMG).

Hereinafter, a method for producing a skin moisturizing composition according to an embodiment of the present invention will be described.

1 is a flow chart of a method for manufacturing a skin moisturizing composition according to an embodiment of the present invention.

Referring to FIG. 1, the method for preparing a skin moisturizing composition of the present invention comprises the steps of (S10) preparing a mesoporous silica, (S20) preparing a second solution, (S30) A step (S40) of adding an antimicrobial substance to the third solution, and a step (S50) of stirring the second solution and the third solution.

In step (S10) of producing the mesoporous silica, mesoporous silica having a pore size of 2 nm to 30 nm is produced.

In the step S20 of preparing the second solution, a second solution which is a liquid moisturizing substance containing the moisturizing substance is prepared.

In the step (S30) of preparing the third solution, the mesoporous silica produced in the step (S10) of producing the mesoporous silica is dispersed in ethanol, and a third solution containing water and propylene glycol is prepared.

In step S40 of adding the antimicrobial substance to the third solution, the above-mentioned antimicrobial substance such as nanosilver, nano-zinc oxide and the like is added to the third solution.

In the step of stirring the second solution and the third solution (S50), the skin-moisturizing composition of the present invention is prepared by stirring the second solution and the third solution to which the antibacterial substance is added.

Hereinafter, embodiments of the method for preparing a skin moisturizing composition of the present invention will be described in detail.

[ Example One] Mesoporous Preparation of silica

First, 30 g of P-123, 848 g of distilled water, 56 g of hydrochloric acid, and 64 g of silica precursor TEOS were mixed, and the first solution was stirred at room temperature for 20 minutes.

Here, P-123 means a triblock copolymer having the formula HO (CH ₂ CH ₂ O) ₂ O (CH ₂ CH (CH ₃ ) O) ₇₀ (CH ₂ CH ₂ O) ₂ OH.

Next, the first solution was heated at 40 캜 for 24 hours, and then the first solution was further heated at 100 캜 for 24 hours.

Then, the first solution which had been stirred was filtered to separate the first mixture. The separated solid first mixture was washed three times with distilled water, dried at 80 DEG C and then calcined at 550 DEG C for 3 hours to obtain mesoporous silica powder. Here, the pore size of mesoporous silica was measured from 2 nm to 30 nm.

[ Example 2] Preparation of composition for skin moisturizing

First, wax, jojoba oil, and surfactant were mixed and dissolved in a bath at 60 DEG C to prepare a second solution.

Then, the mesoporous silica powder obtained in Example 1 was dispersed in ethanol, and water and propylene glycol were mixed to prepare a third solution.

Next, hyaluronic acid and sodium lactate are sequentially added to the third solution, and 0.5 to 10 parts by weight of polypropylene glycol having a molecular weight of 1000 or less is added to 100 parts by weight of the third solution .

Further, PHMB (polyhexamethylene biguanide) was further added to the third solution for antibacterial effect and then aged at a temperature of 30 to 60 ° C for 6 to 18 hours.

Then, the second solution and the third solution were mixed and stirred to prepare a first skin moisturizing composition in an emulsion state.

[ Comparative Example 1] Preparation of composition for skin moisturizing

First, wax, jojoba oil, and surfactant were mixed and dissolved in a bath at 60 캜 to prepare a fourth solution.

And a zeolite powder having a pore size of 0.1 nm to 2 nm, which is one of microporous materials, is dispersed in ethanol, and water and propylene glycol are mixed to prepare a fifth solution.

Next, hyaluronic acid and sodium lactate were sequentially added to the fifth solution, and 0.5 to 10 parts by weight of polypropylene glycol having a molecular weight of 1000 or less was added to 100 parts by weight of the fifth solution .

Then, PHMB (polyhexamethylene biguanide) was further added to the fifth solution for antibacterial effect and then aged at a temperature of 30 to 60 ° C for 6 to 18 hours.

Then, the fourth solution and the fifth solution were mixed and stirred to prepare a second skin moisturizing composition in an emulsion state.

[ Experimental Example 1] A composition for skin moisturizing Moisturizing effect

Experiments on the moisturizing effect of the first skin moisturizing composition and the second skin moisturizing composition were conducted on eight subjects having healthy skin of 22 to 30 years old without any history of allergic diseases or atopic dermatitis. The area was limited to the lower limb skin.

The subcutaneous skin of each subject was washed and stabilized for 30 minutes. Then, the first skin moisturizing composition and the first skin moisturizing composition were applied to the subcutaneous skin of each subject.

Then, the moisture content of the subcutaneous skin of each subject was measured.

Table 1 below shows the increase rate of the moisture content of the subcutaneous skin of each subject to which the first skin moisturizing composition was applied after 120 minutes.

Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Subject 6 Subject 7 Subject 8 120 minutes
After
23%
33%
34%
40%
27%
30%
33%
36%

Table 2 below shows the increase rate of the moisture content of the subcutaneous part skin of each subject to which the first skin moisturizing composition was applied after 240 minutes.

Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Subject 6 Subject 7 Subject 8 240 minutes
After
22%
25%
26%
30%
23%
25%
26%
28%

Table 3 below shows the increase rate of the moisture content of the subcutaneous skin of each subject to which the second skin moisturizing composition was applied after the lapse of 120 minutes.

Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Subject 6 Subject 7 Subject 8 120 minutes
After
24%
32%
35%
39%
27%
30%
33%
34%

Table 4 below shows the increase rate of the water content of the subcutaneous skin of each subject to which the second skin moisturizing composition was applied after 240 minutes.

Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Subject 6 Subject 7 Subject 8 240 minutes
After
15%
18%
19%
22%
16%
16%
16%
17%

As shown in Experimental Example 1, the moisture content of the subcutaneous skin of each subject to which the first skin moisturizing composition was applied was maintained to be increased even after a long time elapsed.

However, the moisture content of the subcutaneous skin of each subject to which the second skin moisturizing composition was applied decreased sharply with time.

This is because the mesoporous silica of the composition for moisturizing the first skin is used as a carrier capable of supporting the moisturizing material, thereby delaying the time for the moisturizing material to be expressed from the mesoporous silica.

That is, since the moisturizing material of the present invention is slowly released over a long period of time, the moisturizing effect of the skin can be maintained for a long time.

The foregoing description is merely illustrative of the technical idea of the present invention, and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the scope of equivalents should be construed as falling within the scope of the present invention.

Claims

30 g of a triple copolymer (HO (CH ₂ CH ₂ O) ₂ O (CH ₂ CH (CH ₃ ) O) ₇₀ (CH ₂ CH ₂ O) ₂ OH, 848 g of distilled water, 56 g of hydrochloric acid, Tetraethyl orthosilicate) was mixed for 20 minutes (first step);
Stirring the first solution stirred in the first step for 24 hours while heating to 40 캜 (second step);
Stirring the first solution stirred in the second step for 24 hours while heating to 100 캜 (step 3);
The first solution stirred in the third step is filtered, and the separated solid mixture is washed with distilled water three times, dried at 80 ° C. and then calcined at 550 ° C. for 3 hours to obtain mesoporous silica powder Step 4);
Dissolving a mixture of wax, jojoba oil, and a surfactant in a bath at 60 캜 to prepare a second solution (fifth step);
Dispersing the mesoporous silica powder obtained in the fourth step in ethanol, and mixing water and propylene glycol to prepare a third solution (step 6);
Hyaluronic acid and sodium lactate are sequentially added to the third solution prepared in the sixth step and 0.5 to 10 parts by weight of polypropylene glycol having a molecular weight of 1000 or less is added to the third solution (Step 7);
Further adding PHMB (polyhexamethylene biguanide) to the third solution of the seventh step and aging at a temperature of 30 to 60 DEG C for 6 to 18 hours (step 8); And
Mixing the second solution produced in the fifth step with the third solution aged in the eighth step and stirring the mixture (step 9).

The method according to claim 1,
Wherein the pore size of the mesoporous silica is 2 nm to 30 nm.

In claim 1,
Wherein the solution stirred in the ninth step is in an emulsion state.

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