KR101800448B1 - Sample-receiving device - Google Patents

Abstract

The present invention relates to a sample accommodation device. More specifically, a reagent storage part in which a reagent is filled in a lid of a funnel is detachably coupled, and the reagent in the reagent storage part is released as one side of the reagent storage part touches the inside of the funnel when the lid on the funnel is closed. The released reagent protects constituents after introduced into a storage tank which is filled with the constituents, and the lid on the funnel collects and conveniently stores biomolecules after closed, while being safely movable.

Description

Sample-receiving device

The present invention relates to a sample receiving device, and more particularly, to a reagent storage device in which a reagent storage portion filled with a reagent is detached in a lid of a funnel, and one side of the reagent storage portion contacts with the inside of the funnel when the lid of the funnel is closed, The reagent is discharged, the discharged reagent flows into a storage tank filled with the constituent material to protect the constitution, and the lid of the funnel is sealed so that biomolecules can be collected, conveniently stored, will be.

It is usually desirable to store materials such as liquids, solids, gases or mixtures thereof in containers prior to mixing with other material (s). For example, it may be desirable to package and store components, components, etc., in a container for transportation or safe storage and handling prior to mixing with other materials. A specific example is a case of a toxic compound which needs to be stored securely in a container before the toxic compound is mixed with the detoxifying material.

Another example is where one or more enriched active constituents need to be kept separate from the diluent until just prior to use. It may also be desirable to store or transport the components of the diagnostic or biological preservation before mixing with the biological sample. For example, it may be useful to keep one or more reagent components separated from the donor until the donor's biological sample is collected and placed in the sample receiving device. This is particularly useful in preventing or minimizing the accidental ingestion, contact or loss of one or more reagent components during sample collection.

It may be desirable to deactivate the pathogens / infectious particles in the biological sample by mixing them with the stored material prior to storage or transport or treatment of the sample.

There are various containers for holding the material separately, such as the way in which the user can open the closure to mix the material. Typically, such a container is a dual compartment system in which the material is stored separately and the material is mixed by the user removing the closure of the container.

PCT International Publication WO 2003/104251 describes a container for collecting a biological sample from a subject, and then for stabilizing, preserving or facilitating recovery of the sample, and for mixing the collected sample with the composition. Such a container may comprise a first region for collecting a biological sample, a second region comprising the construct to preserve the nucleic acid, and a second region for retaining a distinct component from the sample between the first region and the second region when in the closed position. And has a barrier. The barrier illustrated in WO 2003/104251 is a rotary compartment. When the lid is attached to the container, the barrier rotates from the original closed position separating the first region and the second region across the container to the open position where the two regions are exposed to each other, Thereby enabling contact between biological samples contained in the region. A disadvantage of such a vessel is that it includes a number of components (e.g., lids, vials, discs, rods, rod holders) that increase the cost of manufacturing the vessel. Additionally, since the disc is held in place by frictional engagement, the components of the container must be precisely manufactured. Although the shape and size of such vessels is quite well suited to collecting biological samples from a donor, it is bulky and / or costly to move without providing high processing of analysis / testing or automation itself.

PCT International Application PCT / CA2006 / 002009 describes a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a tearing member for tearing the membrane of the lid and the membrane seals the substance in the reservoir of the lid until the membrane is torn by the tearing member. The example provided in this application shows twisting the lid during closure to release the material. The container system so presented has two separate parts, and the user needs to adjust the lid and base appropriately before twisting the lid.

Additionally, it may be desirable to use a sample receiving device that can facilitate safe and effective sample collection by non-trained or autonomous donors. For example, when a sample is collected at home or in a remote location, it is not accessible to medical personnel.

Typically, the previous sample receiving device utilizes a sponge or suction mechanism / tool that depends on the location where the sample is placed directly in the device or is held in place and held within the collection device with the sample and (if provided) storage solution.

Depending on the nature of the substance released from the reservoir, the sponge may be degraded or a chemical (e. G., An adhesive) may leach out of the sponge and contaminate the sample. If the sample has a sponge / tool, it may interfere with downstream analysis, for example using a liquid-handling robot. The liquid-handling robot may exhibit an error in contact / collision with the sponge in the sample; While the robot can successfully draw an aliquot through a sponge, a pipette (with a stabbing sponge) can inadvertently contaminate a nearby sample as it passes through the open tube, and in a device for a robot or technician the sample is small Can not be recovered for testing (ie, the sponge can not absorb and retain the sample-material).

In this case, 1) manual removal of the sponge (s) from the sample before storage or analysis, 2) manual recovery of the sample retained in the sponge, and 3) additional processing of collecting the ' . It would be desirable to use a sample collection device and sample collection device that does not leave / leave tools in the container.

There is still a need for an improved sample receiving device for releasably and reliably storing one or more materials.

Such background information is provided for the purpose of informing the applicant of information thought to be related to the present invention. It should be appreciated and should not be construed that any of the foregoing information constitutes prior art to the present invention.

Korean Patent Publication No. 10-2011-0047239

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems,

A reagent reservoir filled with a reagent is detached and attached to the funnel lid. When the lid of the funnel is closed, one side of the reagent reservoir is brought into contact with the inside of the funnel and the reagent in the reagent reservoir is discharged. The object of the present invention is to provide a sample receiving apparatus which is capable of collecting, conveniently storing, and safely moving biomolecules by flowing into a storage tank to protect a constitution and the lid of the funnel being sealed.

To achieve the above object, the present invention provides a sample receiving apparatus for releasably storing a constituent,

The upper and lower parts are opened and the lower part is installed on the upper part of the reservoir for holding the constituent, and the open upper part is formed with a funnel in which a lid is formed to seal the inside part;

And a reagent storage unit that is detachably attached to the inside of the lid of the funnel and discharges the reagent filled in the lid to the storage tank because the lid is closed.

In addition, the funnel of the present invention is formed such that a support plate is formed so that an open lower portion is screwed with an upper portion of a reservoir, and one side of the reagent storage portion is in contact with the reagent storage portion, And a latching protrusion is formed so as to be in close contact with the closed lid.

The lid of the present invention opens and closes the upper part of the opened funnel. The lid is hinged to one side of the funnel and is rotated. The lid has a fixing protrusion protruding from the edge of the funnel to be hermetically sealed. And a detachable protrusion formed with a coupling groove at the center is protruded and formed so as to detach and attach the reagent storage portion.

In addition, the reagent storage unit of the present invention is detachably attached to the inside of the lid, the both ends of which penetrate the reagent reservoir, the reagent is stored therein, and the outer periphery is formed in a multi-end shape;

A lid formed at one end of the bottle to open and close the inside of the bottle;

A protruding portion formed inside the other end of the bottle to be penetrated and protruding outside the bottle, and the protruding portion is moved into the bottle while being in contact with one side of the funnel, so that the reagent in the bottle is discharged through the other end of the bottle The present invention relates to a sample receiving apparatus, and more particularly, to a sample receiving apparatus.

Further, the bottle bar of the present invention includes: a protrusion protruding outside the bottle;

A sealing protrusion formed to protrude in the circumferential direction on the outer circumference of the protrusion and to be in close contact with the inner circumference of the bottle to seal the reagent in the bottle so as not to be discharged to the outside;

And a support portion formed at an end of the protrusion to control a length of the protrusion protruded from the multi-end portion of the bottle to the outside of the bottle.

Further, in the inner middle portion of the lid of the present invention, a fitting protrusion is protruded so as to fit into one through end of the bottle, so that the lid opens and closes one end of the bottle.

As described above, in the sample accommodating apparatus of the present invention, the reagent reservoir filled with the reagent is detached in the lid of the funnel, and when the lid of the funnel is closed, one side of the reagent reservoir is in contact with the inside of the funnel, The reagent is discharged, the discharged reagent flows into the storage tank filled with the constituents to protect the constitution, and the lid of the funnel is sealed, thereby collecting biomolecules, conveniently storing, and safely moving.

1 is a perspective view showing a sample receiving apparatus according to an embodiment of the present invention,
2 is a cross-sectional view showing a lid-closed sample receiving apparatus according to an embodiment of the present invention,
3 is a cross-sectional view of a sample receiving device with a lid opened according to an embodiment of the present invention,
4 is a cross-sectional view illustrating a reagent storage unit according to an embodiment of the present invention.

The present invention having such characteristics can be more clearly described by the preferred embodiments thereof.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Before describing in detail several embodiments of the present invention with reference to the accompanying drawings, it is to be understood that the present invention is not limited to the details of construction and the arrangement of components shown in the following detailed description or illustrated in the drawings will be. The invention may be embodied and carried out in other embodiments and carried out in various ways. It should also be noted that the device or element orientation (e.g., "front," "back," "up," "down," "top," "bottom, Expressions and predicates used herein for terms such as "left," " right, "" lateral, " and the like are used merely to simplify the description of the present invention, Or that the element has to have a particular orientation. Also, terms such as " first "and" second "are used herein for the purpose of the description and the appended claims, and are not intended to indicate or imply their relative importance or purpose.

Therefore, the embodiments described in this specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention and do not represent all the technical ideas of the present invention. Therefore, It is to be understood that equivalents and modifications are possible.

FIG. 1 is a perspective view showing a sample receiving apparatus according to an embodiment of the present invention, FIG. 2 is a sectional view showing a lid-closed sample receiving apparatus according to an embodiment of the present invention, FIG. 4 is a cross-sectional view illustrating a reagent storage unit according to an embodiment of the present invention. FIG.

1 to 4, the sample accommodating device of the present invention is a sample accommodating device capable of collecting, storing, and moving components (such as specimens, biomolecules, etc.) into a storage tank 50, A reagent storage unit 20, and a storage tank 50. [

1 to 3, the reservoir 50 is connected to one side of the funnel 10 so that one side thereof is opened, and the reagent of the sample and reagent storage unit 20 to be inspected is stored therein. At this time, the reservoir 50 is in the form of a transparent tube and can visually confirm a specimen or a reagent provided therein.

The reservoir 50 is threaded to the outer periphery to be screwed with the funnel 10, and the inner bottom surface of the reservoir 50 is provided with a supersonic wave As shown in Fig.

As shown in FIGS. 1 to 3, the funnel 10 is open at the top and the bottom, and the bottom is installed at the top of the reservoir 50 for holding the constituent, and the open top of the funnel 10 A lid 11 for sealing the inside is formed. At this time, the funnel 10 is formed in the form of a vertical plane funnel. The funnel 10 is formed to be sloped upward by the upper limit of the light intensity, and the inclination angles of both sides are formed differently. When the lid 11 is opened or closed, the reagent storage part 20 attached to the lid 11 is not interfered with the inner periphery of the funnel 10, The lid 11 can be opened and closed.

The open bottom of the funnel 10 is screwed into the upper part of the storage tank 50 and the upper part of the storage tank 50 is inserted and screwed into the funnel 10, And a reagent reservoir 12 is formed in the inner side of the reagent reservoir 20 so that the reagent in the reagent reservoir 20 is discharged while one side of the reagent reservoir 20 is in contact with the inside of the reagent reservoir 20. In the support plate 12, (13) is formed.

When the reagent storage unit 20 is contacted with the reagent storage unit 20, the reagent storage unit 20 can be prevented from being scattered to other locations other than the through- As shown in FIG. That is, the support plate 12 is formed in the shape of "┛" on the vertical section.

A locking protrusion 14 protrudes from the upper outer surface of the funnel 10 so as to be in close contact with the closed lid 11. The locking protrusion 14 protrudes horizontally from the upper side of the funnel 10 .

The hinge 15 is coupled to one side of the funnel 10 so as to be rotated and the funnel 10 is attached to an edge of the funnel 10, 10, the engaging projection 16 is protruded to be sealed.

The hooking protrusion 16 protrudes perpendicularly from the edge of the lid 11. The hooking protrusion 16 is engaged with the hooking protrusion 16 so that the hooking protrusion 16 is engaged with the hooking protrusion 16. [ Is further protruded.

A detachable protrusion 17 having a coupling groove (not shown) formed at the center thereof is protruded and formed at an inner center portion of the lid 11 so as to be detachably attached to the reagent storage portion 20. The detachable protrusion 17 has an end The hook portion is further protruded so as to be caught by the coupling protrusion 22 of the reagent storage portion 20. [

1 to 4, the reagent storage unit 20 is detachably attached to the coupling groove of the detachable protrusion 17 formed inside the lid 11 of the funnel 10, and the reagent storage unit 20 is detachably attached to the reagent storage unit 20, The lid 11 closes and is discharged to the storage tank 50. At this time, the reagent storage unit 20 can be attached to and detached from the lid 11 and can be easily replaced.

Here, the reagent storage unit 20 includes a bottle 21, a lid 30 and a bottle bar 40. The bottle 21 is opened so that both ends thereof can pass through to store the reagent, A lid 30 and a bottle bar 40 are formed on both open sides of the bottle 21. At this time, various reagents are provided in the bottle 21 and can be replaced.

The detachable protrusion 17 of the lid 11 is formed at the outer periphery of the end of the bottle 21, The connection protrusions 22 are horizontally protruded. At this time, the end of the bottle 21 on the opposite side where the connection protrusion 22 is formed is inserted into the groove-shaped support plate 12 when the lid 11 is closed to the funnel 10. The inner and outer peripheries of the bottle 21 are formed in a multi-end shape.

The lid 30 is formed at one end of the bottle 21 at the end of the bottle 21 where the connection protrusion 22 is formed to open and close the inside of the bottle 21, And a lid 30 is formed of a rubber material so that the lid 30 can be inserted into one end of the bottle 21 Open and close the end.

The bottle bar 40 is formed on the inner side of the other end of the bottle 21 which is penetrated (opposite the lid 30) and is partially protruded outside the bottle 21, 10 so that the reagent in the bottle 21 is discharged through the other end of the bottle 21 which is penetrated.

The bottle bar 40 includes a protrusion 41 protruding outside the bottle 21 and a protrusion 41 protruding in the circumferential direction on the outer circumference of the protrusion 41, A hermetically sealed protrusion 42 which is in close contact with the inner surface of the bottle 21 so as to seal the reagent in the bottle 21 so as to prevent the reagent from being discharged to the outside and a protruding portion 41 formed on an end of the protrusion 41, And a support portion 43 for controlling the length of the bottle 21 projecting outwardly. That is, the protruding portion 41 and the supporting portion 43 of the bottle bar 40 are formed in the shape of "ㅗ" on the vertical section.

The support protrusion 23 protrudes in the circumferential direction so that the bottle bar 40 is not normally pushed into the bottle 21 at the inner peripheral edge of the bottle 21, The support part 43 of the bar 40 is supported so that the bottle bar 40 does not enter the bottle 21 even if the reagent storage part 20 is normally set up.

The operation of the bottle bar 40 will be briefly described. The bottle bar 40 is provided at one end of the bottle 21 through which the bottle 21 is inserted. The support part 43 is provided in the bottle 21, 41 are protruded to the outside of the bottle 21. When the lid 11 is closed with the reagent storage part 20 attached to the lid 11 of the funnel 10, 41 are pushed into contact with the support plate 12 of the funnel 10 to enter the bottle 21 and the sealing projection 42 is separated from the inner periphery of the bottle 21 to form a gap, The reagent is discharged to the outside through the gap. At this time, the reagent discharged to the outside flows into the storage tank 50 through the through hole 13 of the support plate 12.

10: FUNNEL 11: Lid
12: support plate 13: through hole
14: Hook 15: Hinge
16: fastening protrusion 17: detachment projection
20: reagent storage part 21: bottle
22: connecting projection 23: supporting projection
30: lid 31: fitting projection
40: bottle bar 41: protrusion
42: Closing projection 43: Support
50: Storage tank

Claims (6)

1. A sample receiving device for releasably storing a composition comprising a collected sample and a reagent,
A reservoir (50) which is opened at one side and stores therein a constituent composed of a specimen and a reagent;
A funnel 10 connected to an upper portion of the storage tank 50 and having a lid 11 formed therein for sealing the inside thereof;
The reagent storage part 20 is detachably attached to the inside of the lid 11 of the funnel 10 and the reagent filled in the lid 11 closes and is discharged to the storage tank 50 along the inside of the funnel 10, ; ≪ / RTI >
The reagent storage unit 20 includes a bottle 21 detachably attached to the inside of the lid 11, the both ends of the reagent reservoir 20 passing through the reagent storage unit 20, the reagent being stored therein, and the outer circumference being formed in a multi-
A lid 30 formed at one end of the bottle 21 through which the bottle 21 passes and opening and closing the inside of the bottle 21;
The protrusion is formed inside the other end of the bottle 21 which is penetrated and protrudes outward of the bottle 21. The protrusion is moved into the bottle 21 while being in contact with one side of the funnel 10, A bottle bar (40) for controlling the reagent in the bottle (21) to be discharged through the other end of the bottle (21);
Wherein the sample holder is configured to hold the sample.
The method according to claim 1,
The open bottom of the funnel 10 is screwed into the upper part of the reservoir 50 and the reagent reservoir 20 is sealed with one side of the reagent reservoir 20 being in contact with the inner side of the funnel 10, And a locking protrusion (14) protrudes from the outer surface of the upper surface of the funnel (10) so as to be in close contact with the closed lid (11).
3. The method of claim 2,
The lid 11 opens and closes the upper part of the opened funnel 10 and a hinge 15 is coupled to one side of the funnel 10 to be pivoted. And a detachable protrusion (17) protruding from the inner circumferential surface of the reagent storage portion (20) and having a coupling groove formed at the center thereof is protruded and formed on the inner circumferential portion thereof. Receiving device.
The method according to claim 1,
The bottle bar (40)
A protrusion 41 protruding outside the bottle 21;
A sealing protrusion 42 protruding in the circumferential direction on the outer circumference of the protrusion 41 and closely contacting the inner circumference of the bottle 21 to seal the reagent in the bottle 21 from being discharged to the outside;
A support 43 formed at an end of the protrusion 41 to be engaged with a multi-end of the bottle 21 to control the length of the protrusion 41 protruding outward from the bottle;
Wherein the sample holder is configured to hold the sample.
The method according to claim 1,
A fitting protrusion 31 is protruded from the center of the inner side of the lid 30 so as to fit into one through end of the bottle 21 so that the lid 30 opens and closes one end of the bottle 21. [ Sample acceptance device. delete

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