KR101786914B1 - Adhesive elastic band for skin-lifting or enhancement of skin elasticity - Google Patents

Abstract

The present invention relates to an adhesive elastic band, to a manufacturing method thereof, and to a composition for adhesion having increased skin permeability contained in the same, wherein the adhesive elastic band comprises a support layer comprising a synthetic or natural polymer resin, an adhesive layer and a protective film, wherein the adhesive layer comprises a skin penetration enhancer comprising an adhesive agent, skin condition improving active ingredients, and a self-assembled surfactant cyclic peptide and a mixture of saturated fatty acids and unsaturated fatty acids to physically improve the elasticity of the skin and permeation of skin condition improving active substances such as collagen and a substance for improving production thereof in the body, and to have a low skin stimulus, so it is possible to show various skin condition-improving effects synergistically such as physical and chemical and/or biological anti-sagging or relief, elasticity and wrinkle reduction with a little stimulus.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to an adhesive elastic band for skin lifting or elasticity improvement,

The present invention relates to a resilient band for improving the elasticity of sagged skin or skin, and more particularly, to a resilient band for improving the elasticity of skin or skin, comprising a support layer having excellent elasticity, To an adhesive elastic band exhibiting an excellent sagging and an improvement in elasticity by permeating an active ingredient that promotes elasticity enhancement of the skin to the skin at a high transmittance.

It is a common phenomenon that the flesh of thighs or throats grows or grows as you get older. In order to improve this, an injection filler which causes an expensive pain or a product which uses a mask pack together with a elastic band is circulating. A cumbersome method of attaching a mask pack to the entire face and, in addition, wrapping the elastic band around the head in the neck below the jaw, finally ligation of the elastic band on the head in an appropriate manner is also used. These products are mask packs that provide ingredients that help skin elasticity, and are aimed at lifting facial flesh with elastic bands. These products have a cumbersome inconvenience to use two kinds of products at the same time in order to achieve the effect desired by the user. Also, too much pressure on the elastic bands may cause headaches or various side effects associated with them.

Further, at both side ends of the elastic band, openings are formed in which ear portions are opened so as to be fixed to the ears of the wearer (Korean Utility Model No. 20-2016-0003495, Japanese Utility Model No. 3170873) Although there are prior art techniques for bands that are effective on the elasticity of the shape where the hooks of the wearer's ears are connected to the ends of the band at both ends of the band, it is not only troublesome to wear when worn on the ear protruding from the body, There is a problem that the user feels uncomfortable.

A typical mask pack is applied to a specific part of the face or the whole face to supply moisture or specific nutrients to the facial skin. Thus, there is no lifting effect of lifting the drooping of the face such as a ball or neck, It can not exhibit the effect of the elastic band lifting the sagittal flesh. In addition, a general elastic band generally has elasticity and is not designed to supply necessary nutrients to the skin.

Accordingly, the present inventors have made intensive studies on the elastic band for overcoming the disadvantages of the conventional mask pack and the elastic band as described above. As a result, they have found that the self-assembling surfactant peptide and the fatty acid composition are used together with the elastic support having specific physical properties It shows the effect of improving the skin condition such as excellent skin lifting and elasticity improvement in physical, chemical and biological aspects, but it is free from pain without suffering from pain or running down after wearing it. The present invention has been completed.

Accordingly, it is an object of the present invention to provide a elastic band for improving the elasticity of flesh and skin and a method of manufacturing the elastic band.

Still another object of the present invention is to provide the above-mentioned spot-wearing composition for elastic bands with increased skin permeability.

According to an aspect of the present invention,

A support layer comprising a synthetic or natural polymer resin,

The pressure-

A protective film,

Wherein the pressure sensitive adhesive layer comprises a spotting composition comprising a pressure sensitive adhesive, a skin condition improving active ingredient, and a skin penetration enhancer comprising a self-assembling surfactant cyclic peptide and a mixture of saturated fatty acids and an unsaturated fatty acid, and a viscous elastic band Which has increased skin permeability.

Hereinafter, the present invention will be described in more detail.

In order to provide a flexible adhesive band capable of simultaneously performing two functions, namely, a function of supplying nutrients to skin and a function of lifting and lifting sagittal flesh, a synthetic or natural polymer layer A pressure-sensitive adhesive layer for bringing the elastic band into close contact with the skin and supplying the skin condition improving component, and a protective film which is detached immediately before use. In a preferred embodiment of the present invention, as an alternative to a mask pack in cosmetics, it is desirable to provide a cosmetic composition which not only provides a resilient effect by chemical and / or biological elasticity enhancement or wrinkle reduction component but also maintains a certain physical property, This elastic band is distinguishable from a medical elastic band used for a simple fixation of a surgical site such as a jaw after surgery such as a conventional ear surgery. The adhesive elastic band according to the present invention may be in a form that can be used once or repeatedly, but it is preferably disposable to prevent problems due to contamination of the adhesive layer.

Such a sticky elastic band may be embodied in various shapes that surround a part of the chin and neck and can also cover the face of the face.

Preferably, the elastic band of the present invention can be designed in a dumbbell shape in order to exhibit a maximum lifting effect as a target. Also, the dumbbell-shaped design is characterized in that the mid-concave portion and the wide side portions of both sides are 5:95 to 40:60. Preferably, the area ratio of the concave portion of the middle dumbbell shape to the wide side of the dumbbell shape is 10:90 to 40:60. More preferably, the area ratio of the concave portion of the middle dumbbell shape to the wide side of the dumbbell shape is 15:85 to 40:60.

This is because it is difficult to expect the lifting effect when the elastic hollow band is applied to the face when the area of the concave portion of the middle exceeds 40%, because the force of pulling down is stronger than the lifting force. Also, when the area of the concave portion is 5% or less, the area of the lower jaw and neck is too narrow, so that the lifting effect on this portion is lowered, and the band may be broken when the elastic band is applied to the face. The elastic band according to the present invention has the above-described shape and the unique point-wearing composition described below, so that even if there is no part to be earmuffed, the elastic band can stick to the adhesive force and can be stretched due to its structural characteristics.

The adhesive elastic band according to the present invention is characterized by comprising a synthetic or natural polymer resin having elasticity as a support for supporting the pressure-sensitive adhesive. As the raw material of the synthetic or natural polymer resin having elasticity according to the present invention, various similar polymers including polyurethane can be used, and the raw materials are not limited. For example, the resin may be selected from the group consisting of polyurethane (PU), acrylonitrile butadiene rubber (NBR), styrene-butadiene rubber (SBR), natural rubber (NR), polyvinyl chloride, polyethylene, ethylene-vinyl acetate butyl rubber From a group consisting of latex, silicone rubber, styrene-isoprene-styrene copolymer (SIS), styrene-ethylene-butylene-styrene copolymer (SEBS), polyvinyl alcohol (PVA), elastomer, butyl rubber and chloroprene rubber May be composed of one or more synthetic or natural elastic polymers selected and may be elastomers or polyurethanes. However, the elastomers or polyurethanes are not limited to these, and may be any of those which satisfy the physical properties described in Table 1 Can be used.

The natural or synthetic polymer resin according to the present invention is a porous and elastic material. Preferably, such a natural or synthetic polymer resin support has a porous structure and is less deformed even when used for a long time, has excellent abrasion resistance, It is preferable to have physical properties within a specific range so as to further exhibit superior characteristics.

Specifically, such a resilient natural or synthetic polymer resin simultaneously performs a physical function that allows elasticity for lifting sagging flesh to an appropriate strength and prevents problems such as stretching or tearing abrasion when the band is pulled to the skin It is preferable to have a specifically controlled thickness range. Specifically, in the present invention, the support may be included in the adhesive elastic band at a thickness of 0.1 mm to 3.0 mm. And a thickness of 0.3 mm to 2.0 mm is preferably used. If the thickness is less than the above-mentioned thickness range, it does not have appropriate elasticity and physical strength, and if the thickness is thicker than the above-mentioned thickness range, the adhesion to the curved surface of the face is low.

Further, in order to exhibit excellent abrasion resistance, resilience and restoring force, the support has a physical property with a density of 0.1 to 1.0 g / cm 3, a tensile strength of 0.1 to 20 kgf / cm 2, an elongation of 50 to 400% and a burst strength of 5 to 20 kgf / .

In addition, the most suitable elastic support for lifting the supporter used in the present invention by physical elasticity is the elastic modulus of 0.1 to 5.0. Preferably, the elastic modulus is 0.5 to 5.0. More preferably, the elastic modulus is within 0.5 to 3.0. If the elastic modulus of the elastic support is less than 0.5 as described above, the elasticity of the support is too small to lift the sagging flesh. On the other hand, when the elastic modulus is 5.0 or more, the elasticity of the support increases, . Therefore, when applied to the face, the resilient scaffold can not lift the sagittal flesh, but rather pulls downward more strongly.

In a specific embodiment, when the elastic support of the present invention is a polyurethane foam, the tensile strength (MD) is in the range of 0.5 kgf / cm 2 to 20 kgf / cm 2, the extension at max is 50 to 200% Is in the range of 0.5 to 3.0. The tensile strength MD of the elastic support of the present invention is in the range of 1 kgf / cm 2 to 20 kgf / cm 2, the extension at max is 100 to 500%, the elastic modulus is 0.5 to 5.0 . ≪ / RTI >

In the present invention, the elastic band is characterized by being pulled under the ear while wrapping the ball under the chin. When the elastic band is applied, the elastic band is stretched in a range of 5% to 30% of the entire length of the band. Preferably, the degree of stretching the elastic band is 5% to 20%.

In addition, the elastic support manufactured using the natural or synthetic polymer resin may be manufactured in various forms, but is preferably in the form of a foam or a sheet.

Further, the adhesive elastic band according to the present invention comprises a pressure-sensitive adhesive layer which directly contacts with the face, and the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive composition comprising a pressure-sensitive adhesive, a skin condition improving active ingredient and a skin permeation enhancer.

The pressure-sensitive adhesive contained in the spot-wearing composition may be a mixture of one or more kinds of acrylate-based pressure-sensitive adhesives, silicone-based pressure-sensitive adhesives, and rubber-based pressure-sensitive adhesives.

In addition, the adhesive elastic band provided in the present application has a pressure-sensitive adhesive layer formed by coating the elastic band with a certain thickness on a elastic band which can not be provided by a conventional mask pack. In addition to the pressure-sensitive adhesive, Skin penetration enhancers that enhance or promote skin penetration of these ingredients, along with various active ingredients that help improve skin conditions, such as wrinkles, and the like.

Specifically, the skin condition improving active ingredient may include, without limitation, active ingredients capable of improving various skin conditions such as skin elasticity and wrinkle improvement, whitening, trouble reduction, moisturizing and the like, Lt; / RTI > As a specific example, the dressing composition is an active ingredient closely related to skin elasticity, and may include one or more kinds of active ingredients such as collagen, hyaluronic acid, coenzyme Q-10, retinol, vitamin C and elastin But it is not limited thereto, and it includes all the skin condition improving active ingredients derived from commonly known artificial synthetic ingredients or natural extracts.

The cosmetic composition according to the present invention can be used as a skin condition improving ingredient together with active ingredients such as collagen, hyaluronic acid, coenzyme Q-10, retinol, vitamin C and elastin, . Such components for promoting the production of the skin condition improving agent include biodegradable materials such as poly (lactic acid), PLA, poly (glycolic acid), glycolic acid (PGA), lactic acid / glycolic acid (Lactic acid / glycolic acid copolymer, PLGA or PGLA), Polycaprolactone, Biotide®, Trylagen®, Viniderm®, and Peptiskin® and peptiskin (R). However, the present invention is not limited to these components and may include, without limitation, any of those known to promote the in vivo production of the skin condition improving component .

Preferably, the skin condition improving component may be collagen and may have a weight average molecular weight of 300 to 1000. The biodegradable polymer may be PLGA, PLA or PGLA, and has a weight average molecular weight of 200 to 10,000. . If the molecular weight of collagen, an active ingredient related to skin elasticity, is over 1,000, it is difficult to enter through skin. In addition, if the molecular weight is too low, it will be easily decomposed in the tissues, so that it can not help the skin elasticity. Collagen that passes through the skin acts as a component that helps skin elasticity like collagen in tissues.

Since the biodegradable polymer PLA, PLGA, PGLA, or the like acts as a foreign substance in the tissue, it acts to defend the foreign body in the body or to heal the wound. That is, the leukocyte is injected into the collagen, the biodegradable polymer such as PLA or PLGA, and the macrophage is activated, so that the tissue is proliferated and epithelialized. Therefore, the biodegradable polymer is filled with a new tissue in a portion of the human tissue into which the biodegradable polymer is introduced, thereby exhibiting an effect of increasing elasticity.

Therefore, the spot-wearing composition is applied to the adhesive elastic band of the present invention by forming the pressure-sensitive adhesive layer, and the skin condition improving material and its body-promoting ingredient contained in the pressure sensitive adhesive layer permeate the skin. The skin condition improving substance such as collagen which passed through the skin has the effect of improving the skin condition such as the increase of the direct elasticity and acting as a foreign substance injected from the outside such as the biodegradable polymer, The self-restoring action, etc., synergize with each other, thereby exerting an excellent effect for improving the skin condition.

In order to enhance penetration of the skin, such as the skin-improving active ingredient and the body-promoting ingredient, self-assembling surfactant cyclic peptides (hereinafter, referred to as " self-assembled surfactant cyclic peptides " SASCP) and a mixture of a saturated fatty acid and an unsaturated fatty acid in a specific ratio (hereinafter referred to as a fatty acid mixture).

The SASCP refers to a self-assembled, self-assembled, cyclic peptide having interfacial activity, and is composed of two regions having a functional group capable of electrostatic interaction with a hydrophobic interaction, specifically, an amino acid Region and a hydrocarbon chain region. The amino acid region is a region corresponding to the head in the cyclic peptide and has a functional group capable of electrostatic charge or electrostatic action capable of hydrogen bonding due to electrostatic attraction between molecules in the molecule and neighboring molecules . It is also possible to include 3 to 9 L-amino acids suitable for ring formation and D-amino acids such as L-leucine, D-leucine, L-valine, L- And includes a carboxy group and an amino group. The carboxyl group may exist in the form of -COO ^- M ⁺ (M = metal ion such as Na, K, Ca) which is a functional group having an electrostatic charge.

Also, the hydrocarbon chain region corresponds to the tail and is a region having a hydrophobic interaction with neighboring substances, and is composed of hydrocarbon chains having about 9 to 19 carbon atoms.

The side chains of SASCP can also include hydrophobic alkyl groups or cyclic chains. The side chain may contain from 5 to 15 hydrocarbons. SASCP has a hydrophobic intermolecular or intermolecular hydrophobic interaction when the side chain contains a hydrophobic alkyl group and contributes to forming a finer cyclic structure stably through hydrogen bonding between molecules in the molecule due to amino groups and carboxy groups do.

In a specific embodiment, the SASCP may be a compound such as:

[Chemical Formula 1]

Wherein L * represents an optically active point, L-Leu represents L-leucine, D-Leu represents D-leucine, L-Val represents L-

X is any one amino acid selected from L-leucine, L-isoleucine and L-valine,

R is a linear or branched alkyl group having 9 to 13 carbon atoms which may be substituted with one or two or more substituents selected from the group consisting of an amino group, a hydroxyl group, a phenyl group, an aryl group, an alkanoyl group, an alkenyl group, A nitro group, a halogen atom and the like,

M is hydrogen, an alkali metal, an alkaline earth metal, an optionally substituted amine (including ammonium) (wherein the alkali metals include, but are not limited to, lithium, sodium, potassium, Amines such as methylamine, ethylamine, benzylamine, aniline, diethylamine, dicyclohexylamine, pyrrolidine, morpholine, N-benzyl-N-ethylamine, N- Ethyl aniline, triethylamine, pyridine, etc.).

In a specific embodiment, the SASCP may be included in an amount of 0.01 to 5 parts by weight based on 100 parts by weight of the total of the spotting composition. When the content of SASCP is less than 0.01 part by weight, the effect of increasing the skin permeability is insufficient, and when the content of SASCP is more than 5 parts by weight, skin irritation is caused by SASCP as well as economical disadvantage of high production cost. Preferably 0.01 to 3.5 parts by weight.

The SASCP of the present application stably forms neighboring substances and fine annular structures due to the hydrophobic interaction described above and the self-assembling property through intermolecular or intramolecular hydrogen bonding, and the structure formed by a general surfactant Which is twice as large as that of the first embodiment.

These two types of interactions (hydrogen bonding, hydrophobic interactions) in SASCP are the skin-condition improving active ingredients, such as collagen, hyaluronic acid, coenzyme Q-10, Retinol, vitamin C, elastin, and substances promoting the body's production of the aforementioned skin-condition improving active ingredients.

Meanwhile, the dressing composition according to the present invention is characterized in that a fatty acid mixture is included together with the SASCP in order to excellently improve the adhesive strength of the adhesive elastic band.

The saturated fatty acid contained in the fatty acid mixture is specifically a saturated fatty acid having 10 to 18 carbon atoms For example, be selected from the group consisting of decanoic acid, undecanoic acid, lauric acid, pentadecanoic acid, myristic acid, palmitic acid and stearic acid, but is not limited thereto.

On the other hand, the unsaturated fatty acid contained in the fatty acid mixture is specifically an unsaturated fatty acid having 12 to 24 carbon atoms, for example, palmitoleic acid, oleic acid, linoleic acid, alpha-linolenic acid (omega 3) ≪ / RTI > and lauric acid. These saturated and unsaturated fatty acids are fatty acids that are the main constituents of the skin, lipids, or fatty acids that have a very similar chain length and shape. Saturated fatty acids having the structure most similar to the phospholipid constituent of the skin include, , Palmitic acid, and stearic acid. Unsaturated fatty acids similar to the constituents of the skin include palmitoleic acid, oleic acid, linoleic acid, alpha-linolenic acid (omega 3), and gamma-linolenic acid.

In the present invention, the fatty acid mixture is characterized in that a fatty acid mixture is constituted by using at least one of saturated fatty acid and unsaturated fatty acid, respectively, and there is no particular limitation on the kinds and amounts of the saturated fatty acid and the unsaturated fatty acid.

In a preferred embodiment, the fatty acid mixture may be included in an amount of 0.1 to 30 parts by weight based on 100 parts by weight of the whole point wear composition, and the weight ratio of saturated fatty acid to unsaturated fatty acid is 2: 8 to 8: 2. If it is out of the above range, the adhesive strength of the adhesive elastic band of the present invention may be decreased, skin permeability may be decreased, or skin irritation may occur.

In another preferred embodiment, the mixing ratio of the SASCP: fatty acid mixture is 0.5: 99.5 to 20: 80, and the combination of SASCP and fatty acid mixture is 0.1 to 20% by weight based on the total weight of the SPF .

Fatty acids contain carboxyl groups in the head and straight chains of hydrocarbons in the tail, which in turn act as surfactants in aqueous solutions. The fatty acid mixture is a mixture of saturated fatty acids and unsaturated fatty acids similar to the constituents of the skin in a specific mixing ratio. In addition to the self-assembled surfactant cyclic peptides (SASCP), the fatty acid mixture composed of the saturated fatty acid and the unsaturated fatty acid has hydrogen bonding by the electrostatic attraction and hydrophobic action by the hydrocarbon chain to form a more stable fine adhesive layer, As a result, the adhesive elastic band of the present invention including the adhesive layer increases the skin adhesion force, and in addition, plays an important role in increasing the skin permeation upon application of the skin condition improving active ingredient.

The protective film included in the adhesive elastic band according to the present invention may be a release film commonly used in a transdermal formulation such as a mask pack or a laminate thereof. For example, a film, paper, or a laminate thereof such as polyethylene, polyester, polyvinyl chloride, or polyvinylidene chloride coated with a silicone resin or a fluorine resin can be used.

In a specific embodiment, the skin permeation promoting effect of the adhesive component contained in the adhesive elastic band according to the present invention was confirmed by a microscopic photograph using collagen and a fluorescent substance. As a result, it was found that the skin condition improving substance such as collagen permeated the skin . Further, as a result of clinical application of the adhesive elastic band according to the present invention to actual skin, it can be confirmed that the elasticity of the hanging tuck or the tongue is actually increased and lifted.

In another aspect, the present invention relates to a method of making such a viscous elastic band comprising the steps of:

a) preparing a natural or synthetic polymeric resin support using natural or synthetic polymers;

b) mixing the active ingredient, the self-assembled surfactant peptide and the fatty acid mixture to improve the skin condition to produce a spotting composition;

c) applying the spotting composition prepared in step b) to the support prepared in step a) to form a pressure sensitive adhesive layer; And

d) applying a protective film on the non-contact side of the support of the adhesive layer of the product prepared in step c).

The matters described in the above adhesive elastic band can be applied to the natural or synthetic polymer, the skin condition improving active ingredient, the self-assembling surfactant peptide, the fatty acid composition and the protective film, which are used in the above manufacturing method.

The tacky elastic band according to the present invention not only does not flow down when applied to the skin, specifically the face skin, lifts the slack with appropriate elasticity to physically improve the elasticity of the skin, but also improves the skin condition improving active substance such as collagen, It has the advantage of synergistically improving various skin conditions such as physical, chemical and / or biological sagging prevention or relaxation, elasticity and wrinkle improvement with low stimulation while improving the permeation of materials improving the production, .

Figs. 1 to 5 are photographs of a skin permeation test using a fluorescent substance taken by a microscope. Specifically, HA-F permeation test Example 1), Figure 2: HA-F permeation test Comparative Example 1), Figure 3: HA-F Blank permeation test Comparative Example 2), Figure 4: Collagen- Test Comparative Example 3), Fig. 5: Collagen-F skin permeation test Example 2).
FIG. 6 is a graph showing the rate of change of jaw elasticity after applying the adhesive elastic band according to the present invention.
FIG. 7 is a graph showing changes in lowering lifting after applying the adhesive elastic band according to the present invention. FIG.
FIG. 8 is a photograph of the skin elasticity after applying the adhesive elastic band according to the present invention by f-ray.

Experimental Example  1: Physical properties of the elastic support according to the present invention

In order to confirm the physical properties of the elastic support prepared according to the present invention, the following polyurethane foams, polyurethane sheets and polyurethane foams were supplied from Daewon Chemical Co., Ltd.

The stamped polyurethane foam, polyurethane sheet and polyurethane foam prepared as described above were measured by the following method. Specifically, the tensile strength (MD) was measured by the Standard Test Method for Tensile Properties of Plastics (ASTM D638-10), and was measured six times using the Type 1 test piece. The tear strength was measured by the burst strength test of the ASTM D3787 fabric Ball burst method). The results are shown in Table 1 below.

Properties of elastic support thickness
(mm) The tensile strength
Kgf / ㎠ Shindo
Extension at max (%) Burst strength
kgf / cm2 Modulus of elasticity Polyurethane sheet 0.6 5.3 ± 0.89 209 ± 15.26 9.34 ± 0.07 1.640 Polyurethane foam 0.9 1.8 ± 0.25 147 ± 18.4 10.89 ± 0.65 1.195

Experimental Example  2: Fluorescent material  Self-assembled interfacial active annulus Peptides  And fatty acid mixture in skin

It is expected that the self-assembled surfactant cyclic peptides (SASCP) and fatty acid mixture will increase the skin penetration of active ingredients in the skin.

Hyaluronic acid (Hyalo-oligo, QP) and collagen (nano collagen, Amicon) were labeled with a fluorescent substance and used for skin permeation test. The skin permeation test was carried out by using human cadaver skin purchased from Han's Biomed at a temperature of minus 75 ° C and spontaneously thawing immediately before use. A pH 7.4 phosphate buffer solution was filled in a Diffusion Franz Cell and the temperature was set at 37.5 ° C , And skin samples were collected at 0.5 h, 1 h and 3 h after application of the composition. The skin tissues collected at each sampling time were pretreated with abion and slides were used to make samples. Fluorescent materials penetrating the skin tissues were photographed with a confocal microscope. The results are shown in the table below. Examples and comparative examples used in the skin penetration test are shown in Tables 3 to 7 below. In the following examples and comparative examples, SASCP and fatty acid mixtures were prepared at a mixing ratio of 11: 89, and the mixing ratio of saturated fatty acid to unsaturated fatty acid in the fatty acid mixture was 35: 65.

Myristic acid, palmitic acid and stearic acid were used as saturated fatty acids. Palmitoleic acid, oleic acid, linoleic acid and linolenic acid were used as unsaturated fatty acids. Specific mixing ratios are shown in Table 2 below.

ingredient ratio(%) Saturated fatty acid Myristic acid 1 to 10 Palmitic acid 20 ~ 30 Stearic acid 1 to 10 Unsaturated fatty acid Palmitoleic acid 1 to 10 Oleic acid 30 to 40 Linoleic acid 10-20 Linolenic acid 1 to 10

Composition for HA-F (hyaluronic acid-fluorescent substance) permeation test (Example 1) ingredient content(%) HA-F (hyaluronic acid-fluorescent material) 2% SASCP + fatty acid mixture 15% Tween 60 2% Propylene glycol 21% Aquaxyl 10% Purified water 50%

Composition for HA-F (hyaluronic acid-fluorescent substance) permeation test (Comparative Example 1) ingredient content(%) HA-F (hyaluronic acid-fluorescent material) 2% SASCP + fatty acid mixture 15% Tween 60 2% Aquaxyl 14% Space peptide One% Purified water 66%

HA-F (hyaluronic acid-fluorescent substance) Blank Composition for permeation test (Comparative Example 2) ingredient content(%) HA-F (hyaluronic acid-fluorescent material) 2% Purified water 98%

Collagen-F (collagen-fluorescent substance) Blank Composition for permeation test (Comparative Example 3) ingredient content(%) Collagen-fluorescent material 2% Ethylcellulose polymer 9% Acrylate tackifier 72% Tween 60 2% Moisturizing Peptide (TRYLAGEN®) 2% glycerin 10% HCO-60 2% Polylactic acid MW2,000 ~ 4,000 One%

Composition for Collagen-F (collagen-fluorescence) permeation test (Example 2) ingredient content(%) Collagen-fluorescent material 2% Ethylcellulose polymer 9% Acrylate tackifier 67% SASCP + fatty acid mixture 5% Tween 60 2% Moisturizing Peptide (TRYLAGEN®) 2% glycerin 10% HCO-60 2% Polylactic acid MW2,000 ~ 4,000 One%

The skin penetration test results of the fluorescent materials are summarized in Table 8 below.

Skin penetration test result of fluorescent substance Furtherance Skin penetration depth (um) of fluorescent material 0.5h 1h 3h HA-F permeation test Example 1) 6-14 12-14 15 ~ 22 HA-F permeation test Comparative Example 1) 7-14 14-18 17-30 HA-F Blank Penetration Test Comparative Example 2) 2-3 6-7 4-8 Collagen-F Blank Penetration Test Comparative Example 3) 3 ~ 3.9 3.4 to 3.7 3.0 to 3.2 Collagen-F Permeation Test Example 2) 9 30 30-50

The HA-F (hyaluronic acid-fluorescent substance) permeation test, which is a composition containing self-assembled surfactant cyclic peptides (SASCP) and SY-Mixture, was compared with the HA-F Blank permeation test Comparative Example 1) Excellent skin permeability is exhibited. This indicates that the composition containing the SASCP + fatty acid mixture shows a degree of enhancement of skin permeation of substances having a high molecular weight such as hyaluronic acid to 200% or more as compared with blank. (CTX Technology, etc.) in comparison with the composition containing the SASCP + fatty acid mixture of the present invention, which is known to promote skin permeation of substances such as hyaluronic acid having a large molecular weight, And HA-F permeation test Comparative Example 1). As can be seen in Table 8, HA-F permeation test example 1) and HA-F permeation test comparative example 1) show almost similar results. That is, compared with the combination of SASCP and a fatty acid mixture and a space peptide in combination, the skin penetration effect when used alone in a composition containing a mixture of SASCP and a fatty acid is substantially equivalent to that of skin The skin permeation effect of the space peptide is relatively low and the skin penetration effect by the mixture of SASCP and fatty acid used in the present invention is much superior to that of the skin penetration effect of the space peptide Able to know.

Collagen-F Permeation Test Example 2) and Collagen-F Blank Permeation Test Comparative Example 3 also shows that the skin permeability of collagen is very excellent by a composition containing a mixture of SASCP and a fatty acid. Skin penetration test results show that the compositions containing the composition containing the SASCP and the fatty acid mixture show a gradual increase in skin permeability with time. In addition, Table 8 shows that the penetration effect of the skin increases up to 3 hours and then maintains a constant level. Despite the fact that the molecular weight of collagen is hardly more than 400 (Indian J. Pharm. Sci. 2008, Jan-Feb; 70 (1): 96-96), which is an effective ingredient capable of permeating the skin, And high molecular weight collagen also shows that the skin penetration degree is remarkably improved by a composition containing a mixture of SASCP and fatty acid.

Experimental Example  3: Clinical study on improving the elasticity of the adhesive elastic band according to the present invention

As the elastic support, a polyurethane foam having a thickness of 0.5 to 1.0 mm provided by Daewon Chemical Co., Ltd. was used. The composition containing the active ingredient and the pressure-sensitive adhesive solution was coated on a silicone-coated polyester film to a predetermined thickness, and dried at 100 to 120 ° C for about 1 to 10 minutes in hot air to prepare a pressure-sensitive adhesive layer having a solid- The polyurethane foam was lined with the polyurethane foam, cut into a shape of a predetermined product, and molded to form a elastic band.

The clinical effects according to the human body application of the present invention were as follows. The application method was to measure the rate of change in mandibular lifting (%) and change in jaw elasticity (%) when using the product for 4 weeks. In this study, women aged 20 to 55 years were divided into 4 groups and used for 2 weeks. Subjects were evaluated before, after, and after 3 hours, 5 hours, and 8 hours after use, at 24 hours after use, at 1 week after use, at visit 3 Each item was evaluated after 2 weeks of use. The number of participants in the clinical trials was 3 per group. The rate of change of mandibular lifting was measured by angle analysis after F-ray and the rate of change of jaw elasticity was measured by cutometer. As a control group, a commercially available elastic cream was used. The percent change in mandibular lifting (%) and the change in jaw elasticity (%) of the present invention were compared with the elasticity cream, which is a comparative product. The results of the clinical effects of the present invention are shown in Figs. The results of the F-ray tilting angle analysis showed that the wrinkles of the wrists were improved by about 10% immediately after use, and that the angled wrists were lifted after 2 weeks of use, and the angular portions were smoothly improved by 5% and the whitening effect was also exhibited.

As shown in the results of FIGS. 6 to 8, among the clinical effects of the elastic band of the present invention, the jaw elasticity change rate (%) and the change rate of the lower jaw lifting (%) gradually increase Can be confirmed. The change of jaw elasticity (%) and the change of mandibular lifting (%) were less effective than the control elasticity cream immediately after use, but gradually increased over time, indicating that it was more effective than the control group after 2 weeks of use. Therefore, it was confirmed that the elastic band of the present invention is effective for jaw elasticity and mandibular lifting when it is continuously used for two weeks or more.

Claims (23)

A support layer comprising a synthetic or natural polymer resin,
The pressure-
A protective film,
Wherein the pressure sensitive adhesive layer comprises a skin penetration enhancer comprising a pressure sensitive adhesive, a skin condition improving active ingredient, a component for promoting body formation of the skin condition improving active ingredient, and a self-assembling surfactant cyclic peptide and a mixture of a saturated fatty acid and an unsaturated fatty acid ≪ / RTI > by weight of the composition. [2] The adhesive elastic band according to claim 1, wherein the viscous elastic band has a dumbbell shape and is stretched in a range of 5% to 30% of the entire length of the support when applied to the face of the face on the neck of the jaw. , Adhesive elastic band. The method according to claim 1, wherein the support layer comprises at least one of polyurethane (PU), acrylonitrile butadiene rubber (NBR), styrene-butadiene rubber (SBR), natural rubber (NR), polyvinyl chloride, polyethylene, ethylene- (EVA), latex, silicone rubber, styrene-isoprene-styrene copolymer (SIS), styrene-ethylene-butylene-styrene copolymer (SEBS), polyvinyl alcohol (PVA), elastomer, butyl rubber and chloroprene rubber Wherein the adhesive elastic band comprises one or more synthetic or natural elastic polymeric resins selected from the group consisting of: 2. The method of claim 1, wherein the support has a thickness of 0.3 to 2.0 mm, a density of 0.1 to 1.0 g / cm 3, a tensile strength of 1 to 20 kgf / cm 2, an elongation of 50 to 400%, a burst strength of 5 to 20 kgf / cm 2, Wherein the adhesive elastic band has a physical property. The adhesive elastic band according to claim 1, wherein the skin condition improving active ingredient is at least one selected from the group consisting of collagen, hyaluronic acid, coenzyme Q-10, retinol, vitamin C and elastin. 6. The adhesive elastic band according to claim 5, wherein the collagen has a weight average molecular weight of 300 to 1000. The adhesive elastic band according to claim 1, wherein the pressure sensitive adhesive is at least one selected from the group consisting of an acrylic pressure sensitive adhesive, a silicone pressure sensitive adhesive and a rubber pressure sensitive adhesive. delete 2. The adhesive elastic band according to claim 1, wherein the component promoting the body production of the skin condition improving active ingredient is a biodegradable polymer having a weight average molecular weight of 200 to 10,000. The adhesive elastic band according to claim 1, wherein the skin penetration enhancer comprises a self-assembling surfactant cyclic peptide and a fatty acid mixture. 2. The peptide of claim 1, wherein the self-assembling surfactant cyclic peptide comprises an amino acid region of 3 to 9 amino acids and a hydrocarbon chain of 9 to 19 carbon atoms, wherein the amino acid region constitutes a ring- Wherein the hydrocarbon chain is a peptide comprising the tail portion. 12. The adhesive elastic band according to claim 11, wherein the amino acid is selected from the group consisting of L-leucine, D-leucine, L-valine and L-isoleucine. 2. The adhesive elastic band according to claim 1, wherein the self-assembling surfactant cyclic peptide is included in an amount of 0.01 to 5 parts by weight based on 100 parts by weight of the total point-wearing composition. The adhesive elastic band according to claim 1, wherein the fatty acid mixture comprises a mixture of saturated fatty acids having 10 to 18 carbon atoms and unsaturated fatty acids having 12 to 24 carbon atoms. 15. The method according to claim 14, wherein the saturated fatty acid having 10 to 18 carbon atoms is at least one selected from the group consisting of decanoic acid, undecanoic acid, lauric acid, pentadecanoic acid, myristic acid, palmitic acid and stearic acid. Adhesive elastic band. 15. The method according to claim 14, wherein the unsaturated fatty acid having 12 to 24 carbon atoms is at least one selected from the group consisting of palmitoleic acid, oleic acid, linoleic acid, alpha-linolenic acid (omega 3) and gamma linoleic acid , Adhesive elastic band. 15. The adhesive elastic band according to claim 14, wherein the mixing ratio of the saturated fatty acid having 12 to 18 carbon atoms and the unsaturated fatty acid having 12 to 24 carbon atoms is 8: 2 to 2: 8. The adhesive elastic band according to claim 1, wherein the self-assembling surfactant cyclic peptide: fatty acid mixture is used in a weight ratio of 0.5: 99.5 to 20: 80. 2. The adhesive elastic band according to claim 1, wherein the self-assembling surfactant cyclic peptide and the fatty acid mixture are contained in the range of 0.1 to 20% by weight based on the total weight of the spotting composition. The adhesive elastic band according to claim 1, wherein the viscous elastic band has a dumbbell shape, and the ratio of the area of the concave portion of the center portion to the area of the wide portion at both ends is from 5:95 to 40:60. A skin penetration enhancer composition comprising a skin permeation enhancer comprising a pressure sensitive adhesive, a skin condition improving active ingredient, a component for promoting body formation of the skin condition improving active ingredient, and a mixture of a self-assembling surfactant cyclic peptide and a saturated fatty acid and an unsaturated fatty acid . a) preparing a natural or synthetic polymeric resin support using natural or synthetic polymers;
b) preparing a spotting composition by mixing a skin condition improving active ingredient, a body stimulating ingredient of the skin condition improving active ingredient, a self-assembling surfactant peptide and a fatty acid mixture;
c) applying the spotting composition prepared in step b) to the support prepared in step a) to form a pressure sensitive adhesive layer; And
d) applying a protective film on the non-contact side of the support of the pressure sensitive adhesive layer of the product prepared in step c).
A process for producing a sticky elastic band according to any one of claims 1 to 7 and 9 to 20. The method according to claim 1,
The ingredient that promotes the body's production of the skin condition improving active ingredient,
Poly (lactic acid), PLA), poly (glycolic acid, PGA), lactic acid / glycolic acid copolymer (PLGA or PGLA), polycaprolactone Wherein the adhesive is at least one selected from the group consisting of Polycaprolactone, Biotide®, Trylagen®, Viniderm®, and peptiskin®. band.

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