KR101786786B1 - 개선된 피브린 밀봉 방법 - Google Patents

개선된 피브린 밀봉 방법 Download PDF

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Publication number
KR101786786B1
KR101786786B1 KR1020127022330A KR20127022330A KR101786786B1 KR 101786786 B1 KR101786786 B1 KR 101786786B1 KR 1020127022330 A KR1020127022330 A KR 1020127022330A KR 20127022330 A KR20127022330 A KR 20127022330A KR 101786786 B1 KR101786786 B1 KR 101786786B1
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South Korea
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fibrin
fibrinogen
solid
component
liquid
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Expired - Fee Related
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KR1020127022330A
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English (en)
Korean (ko)
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KR20120128132A (ko
Inventor
에레즈 일란
이스라엘 누르
크피르 레게브
Original Assignee
옴릭스 바이오파머슈티컬스 리미티드
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Publication of KR20120128132A publication Critical patent/KR20120128132A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127022330A 2010-01-28 2011-01-27 개선된 피브린 밀봉 방법 Expired - Fee Related KR101786786B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29912710P 2010-01-28 2010-01-28
US61/299,127 2010-01-28
PCT/IL2011/000092 WO2011092694A2 (en) 2010-01-28 2011-01-27 Method for improved fibrin sealing

Publications (2)

Publication Number Publication Date
KR20120128132A KR20120128132A (ko) 2012-11-26
KR101786786B1 true KR101786786B1 (ko) 2017-10-18

Family

ID=43923707

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127022330A Expired - Fee Related KR101786786B1 (ko) 2010-01-28 2011-01-27 개선된 피브린 밀봉 방법

Country Status (14)

Country Link
US (2) US8962033B2 (enExample)
EP (1) EP2528631B1 (enExample)
JP (1) JP5859461B2 (enExample)
KR (1) KR101786786B1 (enExample)
CN (1) CN102791299B (enExample)
AU (1) AU2011210356B2 (enExample)
BR (1) BR112012018970B1 (enExample)
CA (1) CA2787883C (enExample)
DK (1) DK2528631T3 (enExample)
ES (1) ES2513516T3 (enExample)
MX (1) MX2012008845A (enExample)
RU (1) RU2556960C2 (enExample)
WO (1) WO2011092694A2 (enExample)
ZA (1) ZA201206438B (enExample)

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IL234246A0 (en) * 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
CA2960589A1 (en) 2014-09-11 2016-03-17 Omrix Biopharmaceuticals Ltd. Addition to a medical applicator
US9801983B2 (en) * 2014-12-18 2017-10-31 Cook Medical Technologies Llc Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices
US20170128617A1 (en) * 2015-11-11 2017-05-11 Ethicon, Inc. Sealant formulation and uses thereof
IL247821A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Adhesive preparations and their use
US12115356B2 (en) * 2019-03-06 2024-10-15 Gambro Lundia Ab Device and method for the delivery of a thrombin activated fibrin sealant
KR102093839B1 (ko) * 2019-05-28 2020-05-04 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
US11666682B2 (en) * 2020-08-31 2023-06-06 Ethicon, Inc. Method of stopping CSF leaks and apparatus therefor

Citations (4)

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US4427650A (en) 1981-06-25 1984-01-24 Serapharm Michael Stroetmann Enriched plasma derivative for advancement of wound closure and healing
JP2002528180A (ja) 1998-10-27 2002-09-03 グラット プロセス テクノロジー ゲーエムベーハー フィブリン組織接着性調剤、及びその製造方法
JP2004521115A (ja) 2001-01-25 2004-07-15 ニコメド ファーマ エイエス 固体フィブリノーゲンおよび固体トロンビンを有する担体
JP2009545424A (ja) 2006-08-04 2009-12-24 エスティービー ライフセービング テクノロジーズ インコーポレイテッド 創傷組織を治療するための固体包帯材

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US5116315A (en) 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
US7208179B1 (en) 1990-11-27 2007-04-24 The American National Red Cross Methods for treating disease and forming a supplemented fibrin matrix
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
US5792835A (en) 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
WO1993005822A1 (en) 1991-09-27 1993-04-01 Octapharma Ag Tissue glue prepared by using cryoprecipitate
WO1994007420A1 (fr) 1992-09-26 1994-04-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Applicateur d'adhesif destine a des tissus
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AT400304B (de) 1994-02-28 1995-12-27 Immuno Ag Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes
WO1996022115A1 (en) 1995-01-16 1996-07-25 Baxter International Inc. Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions
AU708165B2 (en) 1995-06-06 1999-07-29 Interpore International Inc. Wound sealant preparation and application device and method
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US6802822B1 (en) 2000-03-31 2004-10-12 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a flexible link
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PL205685B1 (pl) 2001-05-21 2010-05-31 Omrix Biopharm Sa Sposób in vitro usuwania lub wyodrębniania plazminogenu lub plazminy w obecności fibrynogenu, stałe podłoże powinowactwa do oczyszczania mieszaniny zawierającej fibrynogen i plazminę i/lub plazminogen oraz krioprecypitat
EP1742692A4 (en) 2004-03-17 2012-06-27 Genzyme Corp ANTI-ADHERENCE SPRAY
DE602005013301D1 (de) 2005-11-22 2009-04-23 Omrix Biopharm Sa Applikatorvorrichtung zum aufbringen einer mehrkomponenten-flüssigkeit
ES2649755T3 (es) 2006-11-02 2018-01-15 Omrix Biopharmaceuticals Ltd. Procedimiento de micronización
EP2011524A1 (en) 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrin glue with a visualization agent
JP5805542B2 (ja) 2009-02-20 2015-11-04 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 少なくとも２成分の薬物を投与する装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427650A (en) 1981-06-25 1984-01-24 Serapharm Michael Stroetmann Enriched plasma derivative for advancement of wound closure and healing
JP2002528180A (ja) 1998-10-27 2002-09-03 グラット プロセス テクノロジー ゲーエムベーハー フィブリン組織接着性調剤、及びその製造方法
JP2004521115A (ja) 2001-01-25 2004-07-15 ニコメド ファーマ エイエス 固体フィブリノーゲンおよび固体トロンビンを有する担体
JP2009545424A (ja) 2006-08-04 2009-12-24 エスティービー ライフセービング テクノロジーズ インコーポレイテッド 創傷組織を治療するための固体包帯材

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EP2528631A2 (en) 2012-12-05
WO2011092694A3 (en) 2011-09-29
CA2787883A1 (en) 2011-08-04
DK2528631T3 (da) 2014-09-15
AU2011210356B2 (en) 2015-05-28
CA2787883C (en) 2019-02-19
US8962033B2 (en) 2015-02-24
RU2556960C2 (ru) 2015-07-20
CN102791299A (zh) 2012-11-21
KR20120128132A (ko) 2012-11-26
CN102791299B (zh) 2014-10-22
ZA201206438B (en) 2014-01-29
MX2012008845A (es) 2012-09-28
BR112012018970B1 (pt) 2018-10-30
AU2011210356A1 (en) 2012-08-23
US9302026B2 (en) 2016-04-05
JP5859461B2 (ja) 2016-02-10
EP2528631B1 (en) 2014-08-06
WO2011092694A8 (en) 2012-12-13
US20150125440A1 (en) 2015-05-07
RU2012136648A (ru) 2014-03-10
JP2013517886A (ja) 2013-05-20
US20110182991A1 (en) 2011-07-28
WO2011092694A2 (en) 2011-08-04
BR112012018970A2 (pt) 2017-10-10
ES2513516T3 (es) 2014-10-27

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