KR101765892B1

KR101765892B1 - Sheetless hydrogel patch using cellulose and manufacturing method thereof

Info

Publication number: KR101765892B1
Application number: KR1020150168409A
Authority: KR
Inventors: 김영춘
Original assignee: 주식회사 한국비노프
Priority date: 2015-11-30
Filing date: 2015-11-30
Publication date: 2017-08-10
Also published as: KR20170062790A

Abstract

The present invention relates to a method for manufacturing a sheetless hydrogel patch using cellulose, which can provide excellent mechanical properties and excellent skin-beauty effect to a hydrogel patch using cellulose itself as a support without a substrate layer such as a nonwoven fabric, mesh, (S110) of preparing and mixing a first solution by mixing and stirring glycerin, cellulose, and tocopherol acetate; Mixing and stirring the purified water, sodium carbomer, tartaric acid, and disodium edithiophosphate to prepare a second solution (S120); (S130) of injecting the second solution while stirring the first solution into the blender and stirring the mixed solution of the first solution and the second solution to form a hydrogel by heating; Filtering the hydrogel with a filter (S140); Transferring the filtered hydrogel to a hydrogel coater (S150); Processing the transferred hydrogel to a specific size with a hydrogel coater (S160); Quenching the processed hydrogel through a quencher (S170); A step S180 of forming a hydrogel patch by coating a PET release film on the upper and lower layers so as to maintain the shape of the quenched hydrogel; And a step (S190) in which the hydrogel patch coated with the release film is processed into various forms through a pressing operation.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a method for producing a cellulosic hydrogel,

The present invention relates to a method for preparing a sheetless hydrogel patch using cellulose, and more particularly, to a method for producing a sheetless hydrogel patch by using cellulose as a support without a base layer such as a nonwoven fabric, And a method for manufacturing a sheetless hydrogel patch utilizing cellulose that can provide a skin cosmetic effect.

In modern society, large amounts of active oxygen are generated by ultraviolet rays and water pollution due to exhaust gas, toxic chemical substances, destruction of ozone layer, etc. Such active oxygen penetrates into human body and causes various side effects. In particular, And the like.

In addition, in recent years, outdoor leisure activities such as golf have been increasing in order to overcome the excessive social and work stress. During the leisure activities in such occasions, the body skin is more easily exposed directly to the above pollution sources, And skin aging can not be avoided. This has a negative effect on the tendency to enjoy outdoor leisure activities more positively and comfortably.

On the other hand, a hydrogel is a material having a three-dimensional hydrophilic polymer network structure using purified water as a dispersion medium. Since it exhibits flexibility such as a natural tissue while containing a large amount of water, it can be used as a wound dressing, a contact lens, a medicine, a cosmetic, It is being actively researched and developed in various medicines, cosmetics, and environmental industries including wastewater treatment.

Particularly, hydrogels exhibit a structure similar to that of the human body and are inactive, excellent in elasticity, excellent in transmittance of oxygen and nutrients, and exhibit excellent biocompatibility. Therefore, the hydrogels are attracting more attention in the medical and cosmetic industries. Cosmetic compositions capable of enhancing various moisturizing, nutritional supply or exfoliation effects by controlling the kinds and contents of ingredients used by using elasticity, skin adhesion and soft touch of skin are continuously being developed.

Cellulose is a natural polymer composed of a long chain of glucose units obtained from abundant biomass and having a degree of polymerization of about 10,000.

Nanoceruloses are also renewable and have many advantages such as biodegradability, biocompatibility, high mechanical strength and elastic modulus, high surface area, high aspect ratio, easy chemical modification, dimensional stability, moisture absorption and thermal stability have.

Accordingly, the present inventors have found that by using the excellent properties of a hydrogel, it is possible to provide excellent mechanical properties to a hydrogel patch without using a substrate layer by utilizing the characteristics possessed by the cellulose itself, to clean up the keratin materials on the skin, Thereby minimizing skin troubles and irritation to the skin, and moisturizing and drying the dry and dry skin, thereby completing the present invention.

Domestic Registration No. 10-1461931 (Registered on November 10, 2014) Domestic Registration No. 10-1004329 (registered on December 21, 2010)

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problems, and it is an object of the present invention to provide a hydrogel patch which uses cellulosic itself as a support to make hydrogel patches softer, And to provide a method for manufacturing a sheetless hydrogel patch utilizing cellulose that enables the sugar contained in cellulose to be used as a host in a hydrogel patch.

The present invention also provides a method for manufacturing a sheetless hydrogel patch using cellulose, which can remove not only make-up but also dead skin and dead waste in the pores, minimizes skin troubles and skin irritation, and moisturizes and dries dry and dry skin will be.

The various problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description.

The method for producing a sheetless hydrogel patch using cellulose according to the present invention comprises the steps of mixing and stirring glycerin, cellulose, and tocopherol acetate to prepare a first solution; Preparing a second solution by mixing and stirring the purified water, sodium carbomer, tartaric acid, and disodium edithiophosphate; Introducing the first solution into a blender and adding the second solution while stirring to form a hydrogel by stirring and heating a mixture of the first solution and the second solution; Filtering the hydrogel with a filter; Transferring the filtered hydrogel to a hydrogel coater; Processing the transferred hydrogel to a specific size with a hydrogel coater; Quenching the processed hydrogel through a quencher; Forming a hydrogel patch by coating a release film of PET series on the upper and lower layers to maintain the shape of the quenched hydrogel; And a step in which the hydrogel patch coated with the release film is processed into various forms through a press operation.

As described above, the method for producing a sheetless hydrogel patch using cellulose according to the present invention has an advantage that cellulose itself can be used as a support without a substrate layer such as a nonwoven fabric, a mesh, and a mesh.

In addition, the cellulose itself can make the hydrogel patch softer and richer, and the sugar that cellulose has can be used as a host in a hydrogel patch.

In addition, the benefit of cellulose is that it not only makes up for makeup, but also removes dead skin cells and pores from waste products, minimizes skin troubles and skin irritation, and moisturizes and dries dry, dry skin.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a flow chart of a method for manufacturing a sheetless hydrogel patch utilizing cellulose according to the present invention, in accordance with the present invention.

Advantages and features of the present invention, and methods of accomplishing the same, will be apparent from and elucidated with reference to the embodiments described hereinafter in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the embodiments disclosed herein are provided so that the disclosure can be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the meaning in the context of the relevant art and are to be construed as ideal or overly formal in meaning unless explicitly defined in the present application Do not.

Hereinafter, the sheetless hydrogel patch using cellulose according to the present invention is characterized in that the first solution formed by mixing and stirring glycerin, cellulose, and tocopherol acetate, purified water (including organic purified water), sodium carbomer, And a second solution formed by mixing and stirring the disodium dithiothreitol are mixed, stirred and heated to produce a filtrate and freeze of a hydrogel formed.

Here, the first solution is prepared by mixing and stirring 30 to 40 parts by weight of glycerin, 2 to 6 parts by weight of cellulose, and 0.1 to 0.5 parts by weight of tocopherol acetate with respect to 100 parts by weight of the hydrogel, And 65 to 75 parts by weight of purified water, 0.1 to 2 parts by weight of sodium carbomer, 0.1 to 0.5 parts by weight of tartaric acid, and 0.1 to 0.5 parts by weight of disodium iodide are mixed and stirred with respect to 100 parts by weight of the hydrogel.

The glycerin is preferably used in an amount of 30 to 40 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the glycerin is less than the lower limit, The effect is lowered, the oil film is not formed, the viscosity is lowered, and the gelation does not occur. When the amount of the glycerin exceeds the upper limit, the viscosity becomes too high and cracks occur in the gel.

The amount of cellulose is preferably 2 to 6 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the cellulose is less than the lower limit, the binding force is lowered to gelify the cellulose. If the amount of the cellulose exceeds the upper limit, the binding force is too high to cause precipitation, and some of the components remain unbound.

The tocopherol acetate is preferably used in an amount of 0.1 to 0.5 parts by weight based on 100 parts by weight of the hydrogel, and the tocopherol acetate is preferably used in an amount of 0.1 to 0.5 parts by weight per 100 parts by weight of the hydrogel If the amount of the tocopherol acetate is less than the lower limit, the skin conditioning is deteriorated. If the amount of the tocopherol acetate exceeds the upper limit, the manufacturing cost becomes too high.

The purified water is pure water chemically or physically removed from organic matter and inorganic matter. The purified water is preferably used in an amount of 65 to 75 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the purified water is less than the lower limit, When the amount of the purified water exceeds the upper limit, the concentration is lowered and the hardness is lowered, so that the physical properties of the product are changed and the gelation is not caused.

It is preferable that the sodium carbomer is used as an emulsifier, and the amount of the sodium carbomer is preferably 0.1 to 2 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the sodium carbomer is less than the lower limit, If the amount of the sodium carbomer exceeds the upper limit, the viscosity increases and the use sensitivity decreases.

The amount of the tartaric acid is preferably 0.1 to 0.5 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the tartaric acid is less than the lower limit, the acidity is lowered and the pH If the amount of the tartaric acid exceeds the upper limit, the acidity increases and the skin becomes acidic and irritates the skin.

In addition, it is preferable that 0.1 to 0.5 parts by weight of the disodium is used as a stabilizer, and the disodium is used in an amount of 0.1 to 0.5 parts by weight based on 100 parts by weight of the hydrogel. When the amount of the disodium is less than the lower limit If the amount of the disodium is greater than the upper limit, the physical properties of the product may deteriorate and the feeling of use may deteriorate.

The hydrogel prepared as described above is mixed with a mica as a coloring agent in the first solution to prepare a transparent and opaque hydrogel. The mica is mixed with 100 parts by weight of the hydrogel at 0.5 to 2 parts by weight If the amount of the mica is less than the lower limit, the opacity is lowered. If the amount of the mica exceeds the upper limit, the opacity becomes higher and the spreadability is lowered.

On the other hand, for skin whitening, it may include extracts of mulberry tree, arbutin, ethyl ascorbyl ether, useful licorice extract, ascorbyl glucoside, magnesium ascorbyl palate, niacinamide, alpha-bisabolol, ascorbyl tetraisopalmitate and the like And retinol, retinyl palmitate, adenosine, polyethoxylated retinamide and the like for improving the wrinkles of the skin.

In addition, the first solution and the second solution are prepared separately by separately separating the water-soluble water-soluble raw material and other raw materials and uniformly blending them.

Now, with reference to FIG. 1, a method for manufacturing a sheetless hydrogel patch using cellulose according to the present invention will be described.

First, 30 to 40 parts by weight of glycerin, 2 to 6 parts by weight of cellulose, and 0.1 to 0.5 parts by weight of tocopherol acetate are mixed and stirred with respect to 100 parts by weight of the hydrogel (S110).

Thereafter, 65 to 75 parts by weight of purified water, 0.1 to 2 parts by weight of sodium carbomer, 0.1 to 0.5 parts by weight of tartaric acid, and 0.1 to 0.5 parts by weight of disodium edetate are mixed and stirred with respect to 100 parts by weight of the hydrogel, 2 solution is prepared (S120).

Thereafter, the first solution is put into a blender and stirred while the second solution is mixed at a ratio of 1: 1, and the mixed solution of the first solution and the second solution is stirred and heated (S130). At this time, the mixture is heated to 60 to 90 ° C. until a soft hydrogel is formed through the stirring and heating. If the heating temperature is lower than the lower limit value, it is not properly compounded so that an appropriate amount is not extracted. If the heating temperature exceeds the upper limit The active ingredient is destroyed due to the high temperature.

Thereafter, the stirred and heated gelled hydrogel is filtered with a filter (S140). At this time, the filter is preferably 150 mesh.

Thereafter, the filtered hydrogel is transferred to the hydrogel coater (S150).

Thereafter, the transferred hydrogel is processed into a specific size by an extrusion method through the hydrogel coater (S160).

Thereafter, the processed hydrogel is quenched through a quencher (S170). At this time, the quenchers are maintained at 5 to 10 ° C. If the temperature of the quenchers is lower than the lower limit, the hydrogel solidifies, and if the temperature of the quenchers exceeds the upper limit, do.

Then, the hydrogel having passed through the quencher is coated with a releasing film of PET type on the upper and lower layers to maintain its shape (S180). At this time, the hydrogel becomes a hydrogel patch

Thereafter, the hydrogel patch coated with the release film is processed into various forms through a pressing operation (S190).

The hydrogel patch thus manufactured is packaged through a packaging machine and shipped to the product.

If the stirring speed is lower than the lower limit value, the rotation speed is too slow to be mixed. If the stirring speed exceeds the upper limit value, the rotation speed is too fast Bubbles are generated and components are separated from each other.

Hereinafter, the present invention will be described in more detail with reference to Examples. It will be apparent to those skilled in the art that this embodiment is for illustrative purposes only and that the scope of the present invention is not construed as being limited by the above embodiments.

Example: Production of a sheetless hydrogel patch using cellulose

First, 37 g of glycerin, 4.5 g of cellulose, and 0.3 g of tocopherol acetate are mixed and stirred to prepare a first solution.

Thereafter, 71 g of purified water, 1.4 g of sodium carbomer, 0.25 g of tartaric acid, and 0.25 g of disodium iodide were mixed and stirred to prepare a second solution.

Thereafter, the first solution is put into a blender and stirred, while the second solution is added at a ratio of 1: 1, and the mixed solution of the first solution and the second solution is stirred until a soft hydrogel is formed Heat it.

Thereafter, the hydrogel is filtered with a filter.

Thereafter, the filtered hydrogel is transferred to a hydrogel coater.

Thereafter, the transferred hydrogel is extruded through the hydrogel coater.

Thereafter, the extruded hydrogel is quenched.

Thereafter, a PET type release film is coated on the upper and lower layers of the hydrogel to form a hydrogel patch.

Thereafter, the hydrogel patch coated with the release film is processed into various forms.

As described above, the method for manufacturing a sheetless hydrogel patch using cellulose according to the present invention can use cellulose itself as a support without a substrate layer such as a nonwoven fabric, a mesh, and a mesh. In addition, the cellulose itself can make the hydrogel patch softer and richer, and the sugar that cellulose has can be used as a host in the hydrogel patch. Also, due to cellulose, makeup, as well as removing the dead skin cells and pores in the pores and clean skin, minimize skin irritation and skin irritation, dry and dry skin can be moist and smooth.

Although, in the embodiment of the present invention, topoperol acetate is used as the oil-soluble solvent, it goes without saying that any one kind of tocopherol or four kinds of tocotrienols may be used.

In addition, although purified water is used as the purified water, organic purified water can be used without limitation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Various changes, modifications or adjustments to the example will be possible. Therefore, the scope of protection of the present invention should be construed as including all changes, modifications, and adjustments that fall within the spirit of the technical idea of the present invention.

Claims

Mixing and stirring the glycerin, the cellulose, and the tocopherol acetate to prepare a first solution (S110);
Mixing and stirring the purified water, sodium carbomer, tartaric acid, and disodium edithiophosphate to prepare a second solution (S120);
(S130) of injecting the second solution while stirring the first solution into the blender and stirring the mixed solution of the first solution and the second solution to form a hydrogel by heating;
Filtering the hydrogel with a filter (S140);
Transferring the filtered hydrogel to a hydrogel coater (S150);
The transferred hydrogel was extruded through the hydrogel coater A step S160 of machining to a specific size;
Quenching the processed hydrogel through a quencher to a quenching temperature of 5 to 10 ° C (S170);
A step S180 of forming a hydrogel patch by coating a PET release film on the upper and lower layers so as to maintain the shape of the quenched hydrogel; And
And a step (S190) in which the hydrogel patch coated with the release film is processed into various forms through a press operation (S190).

The method according to claim 1,
Wherein the first solution is prepared by mixing and stirring 30 to 40 parts by weight of glycerin, 2 to 6 parts by weight of cellulose, and 0.1 to 0.5 parts by weight of tocopherol acetate with respect to 100 parts by weight of the hydrogel. A method for producing a sheetless hydrogel.

The method according to claim 1,
The second solution is prepared by mixing 65 to 75 parts by weight of purified water, 0.1 to 2 parts by weight of sodium carbomer, 0.1 to 0.5 parts by weight of tartaric acid, and 0.1 to 0.5 parts by weight of disodium ditallow, based on 100 parts by weight of the hydrogel, Wherein the cellulose is hydrolyzed by stirring.

delete

The method according to claim 1,
In the above steps S110, S120 and S130, the stirring speed is 3,000 to 5,000 rpm;
Wherein the heating temperature of the blender is in the range of 60 to 90 DEG C in step S130.