KR101758813B1 - Toxic substances mixing apaaratus with multiple mixing chamber for environmental risk assessment - Google Patents
Toxic substances mixing apaaratus with multiple mixing chamber for environmental risk assessment Download PDFInfo
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- KR101758813B1 KR101758813B1 KR1020160021664A KR20160021664A KR101758813B1 KR 101758813 B1 KR101758813 B1 KR 101758813B1 KR 1020160021664 A KR1020160021664 A KR 1020160021664A KR 20160021664 A KR20160021664 A KR 20160021664A KR 101758813 B1 KR101758813 B1 KR 101758813B1
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- 239000003440 toxic substance Substances 0.000 title claims abstract description 49
- 231100000614 poison Toxicity 0.000 title claims description 19
- 231100000290 environmental risk assessment Toxicity 0.000 title claims description 4
- 238000001035 drying Methods 0.000 claims abstract description 45
- 231100000167 toxic agent Toxicity 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims description 20
- 231100000331 toxic Toxicity 0.000 claims description 16
- 230000002588 toxic effect Effects 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 239000003595 mist Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 230000007613 environmental effect Effects 0.000 abstract description 7
- 239000002086 nanomaterial Substances 0.000 abstract description 6
- 238000011156 evaluation Methods 0.000 abstract description 4
- 239000007789 gas Substances 0.000 description 50
- 239000002341 toxic gas Substances 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 231100001238 environmental toxicant Toxicity 0.000 description 2
- 239000000383 hazardous chemical Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 231100000016 inhalation toxicity Toxicity 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0011—Sample conditioning
- G01N33/0016—Sample conditioning by regulating a physical variable, e.g. pressure or temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Combustion & Propulsion (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
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- Hydrology & Water Resources (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The present invention relates to an apparatus for generating a toxic substance required for performing a hazard evaluation of an environmental toxic substance including a nanomaterial, and more particularly to a first mixing chamber having an inlet, a mixing unit and an outlet, 1 mixing chamber including a first drying chamber provided at a downstream end of the mixing chamber, a second drying chamber provided at a downstream end of the first drying chamber, and a coil heater provided at a downstream end of the second drying chamber, Mixing device.
Description
The present invention relates to a device for mixing toxic substances required to perform toxicity evaluation of environmental toxic substances including nanomaterials, and more particularly to a device for mixing environmental toxic substances that can be used for inhalation toxicity evaluation of laboratory animals will be.
Nanomaterials, a new paradigm of materials, have emerged as a common and well-known material in everyday life such as tires and coatings. Nanotechnology using nanomaterials refers to the technology of making and manipulating objects at the level of nanometers, where the nanometer is one billionth of a meter (m) It means about one-eighth of the size, which corresponds to about 10 hydrogen atoms arranged side-by-side.
Nanotechnology is the realization of Information Technology (IT) and other biotechnology (BT) today by artificially manipulating atomic or molecular ultrafine materials to create materials or devices with new properties and functions. It is recognized as one of the cutting-edge technologies to do this.
However, nanotechnology, which is recognized as such new technology or advanced technology, offers many advantages and benefits to be recognized as a new technology revolution throughout the industrial field, but on the other hand it has potential risks, The risk is due to the nature of nanotechnology. That is, small particles have a large specific surface area. Thus, a material having a large specific surface area and small particle size may increase the toxicity when reacted with a living tissue. For example, some nanoparticles, such as titanium dioxide, carbon powder, and diesel particles, have been found to be more toxic, such as inflammation, as the size decreases. In addition, ultrafine nanoparticles may not penetrate the airways or mucous membranes but may penetrate deep into the alveoli or migrate to the brain. Recent studies have shown that nanoparticles accumulate in the body, causing diseases or central nervous disorders.
Therefore, techniques for evaluating the toxicity of such nanomaterials are of considerable importance, and toxic materials are manufactured from a toxic material mixing device composed of a particle generator and a dilution chamber, and the toxic substances thus produced are inhaled into a mouse To evaluate toxicity is generally used.
However, the conventional toxic substance mixing apparatus generates a single kind of nanomaterial, and has a problem that it is difficult to precisely control temperature and humidity related to the accuracy of the toxicity evaluation result.
SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an apparatus for mixing an environmental toxic substance, which can easily control temperature and humidity, while containing a plurality of uniformly mixed toxic substances.
In order to achieve the above object, the present invention provides an apparatus for mixing an environmental toxicant, comprising: a first mixing chamber 100 having an
A second mixing chamber 300 is further provided between the first drying chamber 200 and the second drying chamber 400 and a second mixing chamber 300 is provided between the first drying chamber 200 and the second mixing chamber 300. A particulate toxic material inlet pipe may be connected.
In addition, the
The second mixing chamber 300 includes a second
The apparatus for mixing an environmental toxic substance according to the present invention has a plurality of inflow portions and is capable of producing a substance containing a plurality of toxic substances.
Further, the apparatus for mixing an environmental toxic substance according to the present invention has a control unit for continuously measuring temperature and humidity and controlling the temperature and humidity to fall within a predetermined range, thereby minimizing errors of toxic substances.
Furthermore, the environmental toxicant mixing apparatus according to the present invention has an advantage that the particulate toxic substances can be uniformly mixed.
BRIEF DESCRIPTION OF THE DRAWINGS Fig.
2 is a perspective view of the first mixing chamber.
3 is an exploded view of the first mixing chamber.
4 is a perspective view of the first drying chamber.
5 is an exploded view of the first drying chamber.
6 is a perspective view of the second mixing chamber.
7 is an exploded view of the second mixing chamber.
8 is a plan view of the second mixing chamber.
The use of the terms "comprises", "having", or "having" in this application is intended to specify the presence of stated features, integers, steps, components, parts, or combinations thereof, But do not preclude the presence or addition of features, numbers, steps, operations, components, parts, or combinations thereof.
Also, unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, an apparatus for mixing an environmental toxic substance with a multi-mixing chamber according to the present invention will be described with reference to the accompanying drawings.
FIG. 1 is an overall perspective view of the apparatus of the present invention. The apparatus for mixing an environmental toxic substance of the present invention comprises a first mixing chamber 100, a first drying chamber 200 provided at a rear end of the first mixing chamber 100, A second mixing chamber 300 provided at a rear end of the chamber 200, a second drying chamber 400 provided at a rear end of the second mixing chamber 300, a coil heater provided at a rear end of the second drying chamber 400, Detector and a controller.
First, the first mixing chamber 100 will be described in detail with reference to FIGS. 2 and 3. FIG.
The first mixing chamber 100 is an apparatus for primarily mixing toxic substances to be measured and includes an
The
The
The
Here, the sheath gas is not particularly limited as long as it is a gas which does not contain a toxic substance but does not react with the toxic substance.
The mixed gas is discharged through the first
Fig. 4 is a perspective view of the first drying chamber, and Fig. 5 is an exploded view of the first drying chamber. As shown in FIGS. 4 and 5, the first drying chamber 200 provided at the rear end of the first mixing chamber 100 controls the humidity of the first mixed gas. The first drying chamber 200 includes a body 200, A pair of
The
Here, the moisture control agent to be filled in the first drying chamber 200 is preferably a silica gel which is a commonly used moisture control agent, but it is not particularly limited as long as it is a substance capable of controlling moisture.
On the other hand, toxic substances include not only liquid phase, gas phase but also particulate toxic substances. It is also possible to produce a toxic substance containing such particulate matter in the apparatus for producing an environmental toxic substance of the present invention.
As described above, after the liquid toxic substance, the gas toxic substance, and the mist are introduced into the first mixing chamber 100 and mixed therein, the first drying chamber 200 filled with the moisture control agent is adjusted to contain the predetermined humidity do. However, when the particulate toxic substance is directly introduced into the first mixing chamber 100, the particulate toxic substance can be removed during the passage through the first drying chamber 200, and the toxic gas passing through the first drying chamber 200 The injected particulate matter and the toxic gas passing through the first drying chamber 200 are not mixed properly.
Therefore, the present invention may further include a second mixing chamber 300 for perfect mixing even when the particulate toxic substance is injected. After the particulate toxic material is injected into the toxic gas that has passed through the first drying chamber 200, these materials are introduced into the second mixing chamber 300 so that the particulate toxic material is uniformly dispersed in the toxic gas.
As shown in FIGS. 6 to 8, the second mixing chamber 300 includes a second mixing
Particularly, the
8, the second mixing
On the other hand, the second mixing chamber 300 has a remarkable effect when introducing the particulate toxic substance, but it is obvious that the second mixing chamber 300 can be used even when the particulate toxic substance is not introduced. That is, when it is necessary to mix the mixed gas passing through the first drying chamber 200 more completely, the mixed gas may flow into the second mixing chamber 300 and mixed. In addition, the humidity of the toxic gas passing through the second mixing chamber 300 may be measured. If the humidity of the toxic gas passes through the second mixing chamber 300, the humidity may be adjusted to flow into the second drying chamber 400.
Here, the second drying chamber 400 is the same as that of the first drying chamber 200, and a detailed description thereof will be omitted.
Further, it is measured whether the temperature of the mixed gas passing through the second drying chamber 400 falls within a predetermined range. If the temperature exceeds the predetermined range, the temperature can be adjusted to a predetermined temperature by flowing into the coil heater.
The apparatus for generating toxic substances of the present invention may further include a temperature measuring sensor, a humidity measuring sensor, and a plurality of gas conveying pipes, and may further include a control unit for receiving the measured values of the sensor and controlling the flow of the gas.
Having thus described a particular portion of the present invention in detail, those skilled in the art will appreciate that these specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby, It will be apparent to those skilled in the art that various changes and modifications can be made within the scope of the invention, and that such modifications and variations are intended to fall within the scope of the appended claims.
100: first mixing chamber section
110: inlet
111: first gas inlet
112: toxic substance inflow part
120:
121: Perforated plate
122: first coupling member
130:
131: first mixed gas outlet
140: first support
200: first drying chamber part
210:
211: first drying chamber part gas inlet part
212: first drying chamber part gas outlet part
220:
230: Wire Mesh
240: second support portion
250: second coupling member
300: second mixing chamber part
310: second mixing chamber body portion
311: second mixing chamber gas inlet
312: second mixing chamber gas outlet
313: 1st baffle
314: 2nd baffle
315: Third baffle
316: Gasket
320: cover
330: third support portion
400: second drying chamber part
500: coil heater part
Claims (4)
A first drying chamber 200 provided at a rear end of the first mixing chamber 100;
A second drying chamber 400 provided at a rear end of the first drying chamber 200; And
And a coil heater disposed at a rear end of the second drying chamber (400)
The inlet portion 110 of the first mixing chamber 100 includes three toxic material inlet portions 112 into which a liquid toxic substance, a gas toxic substance and a mist are introduced, and a first gas inlet Wherein the toxic material inlet (112) is disposed radially around the first gas inlet (111)
The mixing unit 120 includes a predetermined space portion having a perforated plate 121 having a plurality of pores,
The first drying chamber 200 includes a body 200, a wire mesh 230 for providing a passage through which the mixed gas flows in the first mixing chamber 100 provided in the body 200, And a moisture control agent filled in a space between the wire mesh 230 and the body part 200. The apparatus for mixing toxic substances for environmental risk assessment according to claim 1,
A second mixing chamber 300 is further provided between the first drying chamber 200 and the second drying chamber 400. The first drying chamber 200 and the second mixing chamber 300 are provided with a particulate Wherein the toxic material inlet pipe is connected to the mixing chamber.
The second mixing chamber 300 includes a second mixing chamber body 310 having a predetermined space formed with a second mixing chamber gas inlet 311 and a gas outlet 312.
A cover 320 provided on the body 310; And a third support part 330 spaced apart from the bottom part of the body part 310 by a predetermined distance,
A first baffle 313, a second baffle 314 and a third baffle 315 are installed in the space of the body part 310. The first baffle 313 and the third baffle 315 are connected to the body part 310, And the second baffle (314) is disposed in a space portion between the first baffle (313) and the third baffle (315). An apparatus for mixing toxic substances for an environmental risk assessment.
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KR1020160021664A KR101758813B1 (en) | 2016-02-24 | 2016-02-24 | Toxic substances mixing apaaratus with multiple mixing chamber for environmental risk assessment |
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KR1020160021664A KR101758813B1 (en) | 2016-02-24 | 2016-02-24 | Toxic substances mixing apaaratus with multiple mixing chamber for environmental risk assessment |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101946301B1 (en) | 2017-08-28 | 2019-02-11 | 한국화학연구원 | Multi Particulate Matter Generating System |
KR101946302B1 (en) | 2017-08-28 | 2019-02-11 | 한국화학연구원 | Secondary Particulate Matter Generating System |
KR20190023340A (en) * | 2017-08-28 | 2019-03-08 | 한국화학연구원 | Primary Particulate Matter Generating System |
CN111260208A (en) * | 2020-01-14 | 2020-06-09 | 生态环境部环境规划院 | Regional gridding accumulative environment risk assessment system and method based on risk field |
KR20210081640A (en) * | 2019-12-24 | 2021-07-02 | 전북대학교산학협력단 | Simulation test system for atmospheric pollution matter comprising fine dust |
KR20220059114A (en) * | 2020-11-02 | 2022-05-10 | 인하대학교 산학협력단 | Animal experiment apparatus for performing fine dust exposure experiment |
KR20220059115A (en) * | 2020-11-02 | 2022-05-10 | 인하대학교 산학협력단 | Animal exercise apparatus and method for maintaining animal exercise thereof |
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KR101583041B1 (en) * | 2015-01-07 | 2016-01-06 | 주식회사 그린솔루스 | Toxicity evaluation device of nano material having thermo-hygrostat chamber |
KR101598087B1 (en) | 2015-01-07 | 2016-02-26 | 주식회사 그린솔루스 | Toxicity evaluation device of nano material having active flow controller |
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2016
- 2016-02-24 KR KR1020160021664A patent/KR101758813B1/en active IP Right Grant
Patent Citations (2)
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KR101583041B1 (en) * | 2015-01-07 | 2016-01-06 | 주식회사 그린솔루스 | Toxicity evaluation device of nano material having thermo-hygrostat chamber |
KR101598087B1 (en) | 2015-01-07 | 2016-02-26 | 주식회사 그린솔루스 | Toxicity evaluation device of nano material having active flow controller |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101946301B1 (en) | 2017-08-28 | 2019-02-11 | 한국화학연구원 | Multi Particulate Matter Generating System |
KR101946302B1 (en) | 2017-08-28 | 2019-02-11 | 한국화학연구원 | Secondary Particulate Matter Generating System |
KR20190023340A (en) * | 2017-08-28 | 2019-03-08 | 한국화학연구원 | Primary Particulate Matter Generating System |
KR101964731B1 (en) * | 2017-08-28 | 2019-04-02 | 한국화학연구원 | Primary Particulate Matter Generating System |
KR20210081640A (en) * | 2019-12-24 | 2021-07-02 | 전북대학교산학협력단 | Simulation test system for atmospheric pollution matter comprising fine dust |
KR102390496B1 (en) * | 2019-12-24 | 2022-04-25 | 전북대학교산학협력단 | Simulation test system for atmospheric pollution matter comprising fine dust |
CN111260208A (en) * | 2020-01-14 | 2020-06-09 | 生态环境部环境规划院 | Regional gridding accumulative environment risk assessment system and method based on risk field |
KR20220059114A (en) * | 2020-11-02 | 2022-05-10 | 인하대학교 산학협력단 | Animal experiment apparatus for performing fine dust exposure experiment |
KR20220059115A (en) * | 2020-11-02 | 2022-05-10 | 인하대학교 산학협력단 | Animal exercise apparatus and method for maintaining animal exercise thereof |
KR102529956B1 (en) * | 2020-11-02 | 2023-05-09 | 인하대학교 산학협력단 | Animal exercise apparatus and method for maintaining animal exercise thereof |
KR102529955B1 (en) * | 2020-11-02 | 2023-05-09 | 인하대학교 산학협력단 | Animal experiment apparatus for performing fine dust exposure experiment |
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