KR101709272B1 - Stimulated photoacoustic molecular vibrational imaging system - Google Patents

Stimulated photoacoustic molecular vibrational imaging system Download PDF

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KR101709272B1
KR101709272B1 KR1020150097120A KR20150097120A KR101709272B1 KR 101709272 B1 KR101709272 B1 KR 101709272B1 KR 1020150097120 A KR1020150097120 A KR 1020150097120A KR 20150097120 A KR20150097120 A KR 20150097120A KR 101709272 B1 KR101709272 B1 KR 101709272B1
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laser
light
sample
laser source
lens
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KR20170006470A (en
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김덕영
이창준
소병휘
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연세대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids

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Abstract

The present invention relates to a molecular vibration imaging system, and more particularly, to a molecular vibration imaging system that irradiates laser light of different wavelengths simultaneously with a sample to increase the amplitude of natural vibration of molecules in the sample, To an acoustic molecule vibration imaging system.
To this end, the present invention provides a laser light source comprising: a laser source for irradiating laser light of different wavelengths; A first dichroic mirror for summing the laser beams of the different wavelengths emitted from the laser source and reflecting the combined laser beams in one direction; A first lens for condensing the light reflected by the first dichroic mirror as a sample; And an acoustic sensor for receiving the sound generated by the light condensed by the sample by the first lens; .

Description

[0001] Stimulated photoacoustic molecular vibrational imaging system [0002]

The present invention relates to a molecular vibration imaging system, and more particularly, to a molecular vibration imaging system that irradiates laser light of different wavelengths simultaneously with a sample to increase the amplitude of natural vibration of molecules in the sample, To an acoustic molecule vibration imaging system.

In general, all the atoms constituting the molecule inside the material oscillate with a vibration frequency inherent in the molecule according to their constitution, arrangement structure and bond strength. The vibrational frequency of atoms oscillating within a material has a unique natural frequency that varies from substance to substance. The frequency of this natural vibration is usually 12 to 120 [THz], and when the wavelength is converted into infrared, the infrared wavelength is 2.5 to 25 [um], and the corresponding vibration frequency at a distance of 1 cm is 400 to 4,000 [1 / cm]. At this time, the amplitude of the vibrating atom is proportional to the square root of the temperature of the given material.

By using the spectral characteristics of the unique molecular vibration frequency, different molecules can be distinguished. Therefore, by measuring the molecular vibration frequency spectrum of an arbitrary substance, the components of molecules constituting the substance can be known. For this purpose, infrared spectroscopy (IR spectroscopy), which directly measures the absorption spectrum of infrared rays, or Raman spectroscopy, which measures wavelength transitions of visible light lasers, is used. Infrared spectroscopy or Raman spectroscopy is used to study the vibrational structure of molecules by measuring the vibrational spectrum of molecules or to qualitatively and quantitatively analyze the material. However, since the signal intensity is very small, the measurement time is long and the error is large. Recently, there has been proposed a method of using two or more lasers to generate stimulated Raman scattering (SRS) or coherent Anti-Stokes Raman Scattering (CARS) measurement methods have been proposed to reduce the measurement time and error, and have been applied to the study of biochemical and morphological information of intracellular or extracellular biomaterials.

The following prior art documents are published in U.S. Published Patent Application No. 2011-0239766, which discloses a technique for determining tissue using two or more lasers, but a technique for increasing the acoustic signal by focusing two or more lasers on a sample It has not been published.

In addition, by using the induced photoacoustic molecular vibration imaging system, it is possible to apply the techniques such as early diagnosis of cancer, vascular photograph, diagnosis of abnormality of skin tissue, and endoscopy in the field of biomedical imaging and medical diagnosis equipment in a faster speed and sensitivity Have not been reported.

U.S. Published Patent Application No. 2011-0239766

SUMMARY OF THE INVENTION The present invention has been made in order to solve the problems of the prior art as described above, and it is an object of the present invention to provide an apparatus and a method for diagnosing cancer early diagnosis, vascular photograph, And to provide an induced photoacoustic molecule vibration imaging system.

To this end, the induction photoacoustic molecule vibration imaging system according to the present invention comprises: a laser source for irradiating laser light of different wavelengths; A first dichroic mirror for summing the laser beams of the different wavelengths emitted from the laser source and reflecting the combined laser beams in one direction; A first lens for condensing the light reflected by the first dichroic mirror as a sample; And an acoustic sensor for receiving the sound generated by the light condensed by the sample by the first lens; .

The laser source according to an embodiment of the present invention includes a first laser source for emitting a first wavelength laser light; And a second laser source for irradiating the second wavelength laser light; Wherein the first wavelength and the second wavelength are different from each other.

Further, the first laser source or the second laser source according to the embodiment of the present invention varies the wavelength of the laser light to be irradiated.

Meanwhile, the first wavelength laser light or the second wavelength laser light according to the embodiment of the present invention is a pulse type or a continuous wave type.

The optical modulator adjusts the intensity of the laser light reflected by the first dichroic mirror according to the embodiment of the present invention and irradiates the first lens with the intensity of the laser light reflected by the first dichroic mirror. .

Meanwhile, the laser source according to the embodiment of the present invention may change the time at which the laser light reaches the sample and adjust the degree of overlap in the time axis so that the laser light is irradiated to the sample at least twice. The pulse repetition rate of the source or the second laser source is varied.

A second dichroic mirror that is irradiated with a laser beam whose intensity is controlled by the optical conditioner according to an embodiment of the present invention; And optical coherence tomography (OCT) for analyzing the interference pattern of light reflected from the sample using the laser source and detecting the degree of expansion of the molecule. .

Meanwhile, an optical fiber laser source for irradiating the sample with laser light when the molecule of the sample is vibrated and expanded by the laser light irradiated from the first lens according to the embodiment of the present invention; A scattering plate attached to the sample for scattering laser light irradiated from the optical fiber laser source; A second lens for condensing the laser light and condensing the laser light scattered by the scattering plate; A detector connected to the second lens through an optical fiber for analyzing the laser beam condensed by the second lens to detect the degree of expansion of the molecule; .

Meanwhile, the laser source according to the embodiment of the present invention adjusts the laser pulse repetition rate of the first laser source or the second laser source to change the time at which the laser pulse reaches the sample, And at least two measurements are made and the difference between the two measurements is used to reduce the measurement error.

A galvanometer scanner for two-dimensionally moving the first lens according to an embodiment of the present invention; And the galvano scanner is provided between the first dichroic mirror and the first lens.

The features and advantages of the present invention will become more apparent from the following detailed description based on the accompanying drawings.

Prior to that, terms and words used in the present specification and claims should not be construed in a conventional and dictionary sense, and the inventor can properly define the concept of a term in order to describe its invention in the best possible way Should be construed in accordance with the principles and meanings and concepts consistent with the technical idea of the present invention.

The induction photoacoustic molecular vibration imaging system according to various embodiments of the present invention has the effect of quickly and accurately discriminating the characteristics of a sample through measurement of sound generated by irradiating a laser of a different wavelength to a sample.

Accordingly, the induction photoacoustic molecule vibration imaging system according to various embodiments of the present invention ultimately enables early diagnosis of cancer, imaging of blood vessels, diagnosis of abnormality of skin tissue, and the like in a field of biomedical imaging and medical diagnostic equipment, Endoscope and the like.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram illustrating an induction photoacoustic molecular vibration imaging system according to a first embodiment of the present invention. FIG.
2 is a block diagram illustrating an induced photoacoustic molecular vibration imaging system in accordance with a second embodiment of the present invention.
3 is a block diagram illustrating an induction photoacoustic molecule vibration imaging system according to a third embodiment of the present invention.
4 is a block diagram illustrating an induction photoacoustic molecular vibration imaging system according to a fourth embodiment of the present invention.
5 is a block diagram illustrating an induced photoacoustic molecular vibration imaging system according to a fifth embodiment of the present invention.
6 is a block diagram illustrating an induction photoacoustic molecule vibration imaging system according to a sixth embodiment of the present invention.
FIG. 7 is a block diagram illustrating an induction photoacoustic molecular vibration imaging system according to a seventh embodiment of the present invention. FIG.

BRIEF DESCRIPTION OF THE DRAWINGS The objectives, specific advantages and novel features of the present invention will become more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG. It should be noted that, in the present specification, the reference numerals are added to the constituent elements of the drawings, and the same constituent elements are assigned the same number as much as possible even if they are displayed on different drawings. Also, the terms "first "," second ", and the like are used to distinguish one element from another element, and the element is not limited thereto.

Also, the singular forms as used below include plural forms unless the phrases expressly have the opposite meaning. Throughout the specification, when an element is referred to as "including" an element, it means that it can include other elements as well, without departing from the other elements unless specifically stated otherwise.

The same reference numerals are given to the same members in Figs. 1 to 7.

The present invention can significantly improve the measurement efficiency of the induced Raman scattering by measuring the photoacoustic signal generated in the inductive Raman scattering process instead of measuring the intensity of light scattered in the inductive Raman scattering. Here, the photoacoustic signal is an acoustic signal generated by a sudden thermal expansion that occurs when a laser is absorbed by an object. It is possible to increase the amplitude of the natural vibration of the measuring molecule by simultaneously irradiating the object to be measured with two lasers in which the wavelength (frequency) difference of the laser coincides with the natural frequency of the molecule to be measured. Since the temperature of the target molecule is proportional to the square of the vibration amplitude of the molecule, the temperature around the molecule sharply increases as the natural vibration amplitude of the molecule increases. Since the rapid temperature rise generates a strong acoustic signal due to the photoacoustic effect, information such as the presence or distribution density of molecules having a specific frequency in the sample can be obtained by measuring the intensity of the photoacoustic signal. Accordingly, the present invention relates to an effective induced photoacoustic molecular vibration imaging system using the above phenomenon.

In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a block diagram illustrating an induction photoacoustic molecule vibration imaging system according to a first embodiment of the present invention.

Referring to FIG. 1, an induction photoacoustic molecule vibration imaging system 100 according to a first embodiment of the present invention includes a laser source 110, a first dichroic mirror 120, a first lens 130, Sensor 140 as shown in FIG.

The induced photoacoustic molecule vibration imaging system 100 according to the first embodiment of the present invention shown in FIG. 1 will be described below.

First, the laser source 110 is started. The laser source 110 includes a first laser source 111 that emits a first wavelength laser light and a second laser source 112 that emits a second wavelength laser light. Here, it is appropriate that the first wavelength and the second wavelength are different wavelength ranges. In particular, it is preferable that the difference between the first wavelength and the second wavelength coincides with the natural frequency of the specimen S to be measured. Thus, by simultaneously irradiating the sample S with the laser light having the wavelength difference of the laser light different from the natural frequency of the sample S, the amplitude of the natural vibration of the molecules constituting the sample S can be made large. Since the temperature of the molecule is proportional to the square of the vibration amplitude of the molecule, the temperature around the molecule sharply increases when the natural vibration amplitude of the molecule is increased. Such a sudden temperature rise causes a strong acoustic signal due to the photoacoustic effect. Therefore, by measuring the intensity of such an acoustic signal, information such as presence or distribution density of molecules having a specific frequency in the sample S can be obtained.

It is assumed that the first laser source 111 and the second laser source 112 can vary the respective wavelengths of light to be irradiated, but this is merely an example, and only the first laser source 111 and the second laser source 112 112 can change the wavelength of the laser light.

Next, the first dichroic mirror 120 which reflects laser light having different wavelengths irradiated from the first laser source 111 and the second laser source 112 in one direction will be described below. The first dichroic mirror 120 reflects the first wavelength laser light and the second wavelength laser light, which are radiated in different directions, toward the first lens 130. It is assumed that the first wavelength has a wavelength of lambda 1 and the second wavelength has a wavelength of lambda 2. Therefore, it is preferable that the wavelength reflected from the first dichroic mirror 120 and irradiated is a sum of lambda 1 and lambda 2.

The laser light having the wavelength in which the first wavelength and the second wavelength are combined is condensed by the first lens 130 into the sample S. Here, the first lens 130 can concentrate laser light having different wavelengths on one point on the sample S in three dimensions. Therefore, the first lens 130 is preferably a convex lens for focusing light, but is not limited thereto.

The laser light condensed by the sample S vibrates molecules in the sample S as described above to generate sound. The generated sound is incident on the acoustic sensor 140, and the incident sound can be processed by an analyzer (not shown) to image the state of the sample S. That is, by measuring the acoustic signal generated at the spot where the condensed laser beam is concentrated, the distribution density of specific molecules and the like can be known. For this, a measuring device such as an acoustic sensor 140 or an acoustic scanner (not shown) may be used, and the obtained acoustic information may be input to an analyzer (not shown) to obtain a three-dimensional photoacoustic- . Since the intensity of the generated photoacoustic signal is proportional to the three-dimensional distribution density of the specific molecule, the induced photoacoustic-mechanical-acoustic-vibration imaging system 100 according to the first embodiment of the present invention can obtain the same information as that obtained through the CARS microscope Can be obtained. Meanwhile, the measurement speed of the induced photoacoustic molecular vibration imaging system 100 according to the first embodiment of the present invention is much faster than the conventional CARS microscope, and the measurement sensitivity is also excellent.

The second to seventh embodiments of the present invention will be described below with reference to Figs. 2 to 7. Fig. Prior to the description of FIGS. 2 to 7, the same reference numerals are used for the same constituent elements, and redundant explanations are omitted.

FIG. 2 is a block diagram illustrating an induction photoacoustic molecule vibration imaging system according to a second embodiment of the present invention, and FIG. 3 is a block diagram illustrating an induction photoacoustic system vibrational imaging system according to a third embodiment of the present invention. FIG. 4 is a block diagram illustrating an induction photoacoustic system vibrational imaging system according to a fourth embodiment of the present invention, and FIG. 5 is a view illustrating an induction photoacoustic system vibrational imaging system according to a fifth embodiment of the present invention FIG. 6 is a block diagram illustrating an induction photoacoustic molecule vibration imaging system according to a sixth embodiment of the present invention, and FIG. 7 is a block diagram illustrating an induction photoacoustic molecular vibration imaging system according to a seventh embodiment of the present invention. Fig.

2, the induction photoacoustic-dynamic-molecular-vibration imaging system 100A according to the second embodiment of the present invention includes an induction photoacoustic-molecular-acoustic-vibration imaging system 100 according to the first embodiment of the present invention shown in FIG. 1, And a light modulator 150 as compared to the light modulator 150. That is, the induced photoacoustic acoustic vibration imaging system 100A according to the second embodiment of the present invention further includes a light controller 150 to adjust the intensity of the laser light reflected by the first dichroic mirror 120, 1 lens 130 as shown in FIG. Therefore, the measurer can irradiate the sample S with light of a desired intensity.

Referring to FIG. 3, the induced photoacoustic-mechanical-acoustic-molecule-vibration imaging system 100B according to the third embodiment of the present invention includes the induction photoacoustic-molecular-acoustic-vibration imaging system 100A according to the second embodiment of the present invention shown in FIG. The second dichroic mirror 160 and the optical coherence tomography apparatus 170 as compared to the second dichroic mirror 160 and the optical coherence tomography apparatus 170. [ That is, the induction photoacoustic molecule vibration imaging system 100B according to the third embodiment of the present invention further includes the optical coherence tomography apparatus 170, so that the optical coherence tomography apparatus 170 itself lasers the second die So that it is possible to enter the sample through the touche mirror 160. The laser that has been vibrated by the vibrating molecules by the induced photoacoustic molecule vibration imaging system 100A according to the second embodiment of the present invention can be transmitted to the optical coherence tomography apparatus 170 again.

Referring to FIG. 4, the induction photoacoustic molecule vibration imaging system 100C according to the fourth embodiment of the present invention includes the induction photoacoustic molecular vibration imaging system 100A according to the second embodiment of the present invention shown in FIG. 2 A scattering plate 180, a second lens 130A, a fiber laser source 190, and a detector 140A. For example, a scattering plate 180 having high scattering efficiency is attached to a sample S such as skin, and a laser is irradiated from the optical fiber laser source 190 to the sample S using the second optical fiber B. The molecules that are vibrated by the induced photoacoustic molecular vibration imaging system 100A according to the second embodiment of the present invention then scatter the laser through the scattering plate 180. [ Then, the laser beam scattered through the second lens 130A is focused. Here, the first optical fiber (A) is connected to the second lens 130A, and the laser light can be transmitted to the detector 140A through the first optical fiber (A). Meanwhile, the first optical fiber (A) and the second optical fiber (B) may be connected by WDM (Wavelength Division Multiplexing).

5, the induction photoacoustic-mechanical-acoustic-molecule-vibration imaging system 100D according to the fifth embodiment of the present invention includes an induction photoacoustic-molecular-acoustic-vibration imaging system 100D according to the first embodiment of the present invention shown in FIG. 1 100 in that a galvanometer scanner (G) is further provided. Therefore, the injection position can be two-dimensionally adjusted when the laser beam is injected into the sample S by the galvanometer scanner G. [

Likewise, FIG. 6 is a schematic diagram of a guided photoacoustic-mechanical-acoustic-dynamic-vibration imaging system 100E according to a sixth embodiment of the present invention, 7, the induction photoacoustic molecule vibration imaging system 100F according to the seventh embodiment of the present invention shown in Fig. 7 further includes the scanner (G) It is possible to irradiate the sample S with the laser beam two-dimensionally adjusted by providing the galvanometer scanner G in comparison with the vibration imaging system 100C.

As described above, the induction photoacoustic molecular vibration imaging system 100, 100A to 100F according to various embodiments of the present invention can quickly and accurately determine the characteristics of a sample through measurement of sound generated by irradiating a sample with a laser having a different wavelength .

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the invention as defined by the appended claims. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention.

100, 100A to 100F: Induction photoacoustic molecular vibration imaging system
110: laser source 120: first dichroic mirror
130: first lens 140: acoustic sensor
150: optical regulator 160: second dichroic mirror
170: optical coherence tomography apparatus 180: scatter plate
190: Fiber laser source 130A: Second lens
140A: detector 111: first laser source
112: second laser source A: first optical fiber
B: second optical fiber S: sample

Claims (10)

A laser source for irradiating laser beams of different wavelengths;
A first dichroic mirror for summing the laser beams of the different wavelengths emitted from the laser source and reflecting the combined laser beams in one direction;
A first lens for condensing the light reflected by the first dichroic mirror as a sample; And
An acoustic sensor for receiving the sound generated by the light condensed by the sample by the first lens; , ≪ / RTI &
The laser source
A first laser source for irradiating the first wavelength laser light; And
A second laser source for irradiating the second wavelength laser light; Wherein the first wavelength and the second wavelength are different from each other,
The laser source
Varying the pulse repetition rate of the first laser source or the second laser source that adjusts the degree of overlap in the time axis so that the laser light is irradiated to the sample at least twice by changing the time at which the laser light reaches the sample Wherein the imaging optical system comprises: delete The method according to claim 1,
The first laser source or the second laser source
Wherein the wavelength of the laser light to be irradiated is varied. The method according to claim 1,
The first wavelength laser light or the second wavelength laser light is
Pulse type or continuous wave type imaging optical system. The method according to claim 1,
A light modulator for adjusting the intensity of the laser light reflected by the first dichroic mirror and irradiating the first lens with the intensity of the laser light; Further comprising an imaging system for imaging the excitation light. delete The method of claim 5,
A second dichroic mirror irradiated with laser light whose intensity is controlled by the light adjuster; And
An optical coherence tomography (OCT) system for analyzing an interference fringe of light reflected on the sample using a laser source and detecting the degree of expansion of the molecule; Further comprising an imaging system for imaging the excitation light. A laser source for irradiating laser beams of different wavelengths;
A first dichroic mirror for summing the laser beams of the different wavelengths emitted from the laser source and reflecting the combined laser beams in one direction;
A first lens for condensing the light reflected by the first dichroic mirror as a sample;
An acoustic sensor for receiving the sound generated by the light condensed by the sample by the first lens; And
A light modulator for adjusting the intensity of the laser light reflected by the first dichroic mirror and irradiating the first lens with the intensity of the laser light; , ≪ / RTI &
An optical fiber laser source for irradiating the sample with laser light when the molecule of the sample is vibrated and expanded by laser light emitted from the first lens;
A scattering plate attached to the sample for scattering laser light irradiated from the optical fiber laser source;
A second lens for condensing a laser beam scattered by the scattering plate;
A detector connected to the second lens through an optical fiber for analyzing the laser beam condensed by the second lens to detect the degree of expansion of the molecule; Further comprising an imaging system for imaging the excitation light. A laser source for irradiating laser beams of different wavelengths;
A first dichroic mirror for summing the laser beams of the different wavelengths emitted from the laser source and reflecting the combined laser beams in one direction;
A first lens for condensing the light reflected by the first dichroic mirror as a sample; And
An acoustic sensor for receiving the sound generated by the light condensed by the sample by the first lens; , ≪ / RTI &
The laser source
A first laser source for irradiating the first wavelength laser light; And
A second laser source for irradiating the second wavelength laser light; Wherein the first wavelength and the second wavelength are different from each other,
The laser source
Adjusting at least two measurements by adjusting the laser pulse repetition rate of the first laser source or the second laser source to vary the time at which the laser pulses reach the sample to adjust the degree of overlap in the time axis, And the measurement error is reduced by using the difference between the first and second wavelengths. The method according to claim 1,
A galvanometer scanner for two-dimensionally moving the first lens; Further comprising:
Wherein the galvano scanner is provided between the first dichroic mirror and the first lens.
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US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
US11020006B2 (en) 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
US11137375B2 (en) 2013-11-19 2021-10-05 California Institute Of Technology Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
WO2018209046A1 (en) 2017-05-10 2018-11-15 Washington University Snapshot photoacoustic photography using an ergodic relay
EP3836831A4 (en) 2018-08-14 2022-05-18 California Institute of Technology Multifocal photoacoustic microscopy through an ergodic relay
EP3847453A4 (en) 2018-09-04 2022-06-22 California Institute of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
KR102231835B1 (en) * 2019-06-13 2021-03-25 주식회사 휴비츠 Apparatus and method for tomographic inspection
CN110338768B (en) * 2019-08-21 2024-07-09 西北工业大学 Scanning probe of multi-mode switchable focus locking three-dimensional skin imaging system
WO2021092250A1 (en) 2019-11-05 2021-05-14 California Institute Of Technology Spatiotemporal antialiasing in photoacoustic computed tomography
KR102461021B1 (en) * 2021-03-08 2022-11-01 한국원자력연구원 Vibration measurement apparatus amd vibration measuring method using the same

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