KR101690110B1 - Composition for forming cubic phase structure, cosmetic composition for using the same and method for manufacturing cosmetic composition - Google Patents

Abstract

The present invention relates to a composition comprising 20 to 90% by weight of pyranetriol, 5 to 40% by weight of glyceryl monooleate, 3 to 25% by weight of phosphatidylcholine and 0.1 to 20% by weight of phosphatidylethanolamine The present invention relates to a composition for forming a cubic cubic structure, a cosmetic composition using the same, and a method for producing the same.
According to the present invention, it is possible to provide an optimal cubic cubic structure and to stably encapsulate a percutaneous absorption promoter using the same, thereby providing various formulations for developing highly differentiated highly functional cosmetics and imparting maximum efficacy , And it is possible to achieve significantly higher efficacy by promoting excellent transdermal absorption by enclosing adenosine, niacinamide, vitamins, idebenone, rasberatrol, and caffeine as active ingredients in the cubic cubic structure.

Description

[0001] The present invention relates to a composition for forming a cubic cubic structure, a cosmetic composition using the same, and a method for manufacturing the same,

The present invention relates to a composition for forming a cubic cubic structure, a cosmetic composition using the same, and a method for preparing the same. More specifically, the present invention relates to a cosmetic composition comprising cubic cubic phase The present invention relates to a composition for forming a cubic cubic structure that maximizes the efficacy of a highly functional cosmetic composition, a cosmetic composition using the composition, and a method for producing the same.

In general, basic background techniques for forming cubic cubic structures were developed by Spanish scientists in the early 1990s. The cubic cubic structure consists of a three-dimensional network in which the interior of the particle is cubic. The oil phase and the water phase each have a three-dimensional passageway that is continuous or non-intersecting, and the lipid is divided into two hydrophilic regions separated into intermediate layers. In addition, the internal structure of the nanoparticles is cubic lattice, and has a very regular isotropic structure. When forming such a lattice structure, it is possible to effectively inject drugs having various physical properties into the cubic structure have. These cubic structures are of a continuous lamellar structure, providing a tortuous diffusion path that allows for controlled release and are transparent to the appearance and rheological properties of the crosslinked polymer hydrogels due to the inter- Viscous gel is formed. However, since it is highly viscous and has low fluidity, it is still difficult to use it as a cosmetic and dermatological external agent, and it has not reached the limit of technology and is not universalized.

These liquid crystal structures are characterized by natural, biocompatible, non-accumulating and non-toxic properties because they are based on lipids. In addition, conventional emulsion formulations and liposomal formulations have limitations in filling only fat-soluble or water-soluble drugs, but cubic cubic structure formulations can include more lipophilic and water-soluble drugs as well as amphoteric drugs, thereby enabling a variety of drug encapsulation. However, the most disadvantage is that the cubic structure of the high-viscosity cubic phase can be formed only when the chain length of the hydrophilic group and the lipophilic group is optimized, and the proportional condition of the hydrophilic part and lipophilic part of the lipid molecular structure is different There are many difficult problems to complete a cubic structure which is substantially stable because it is transformed into a hexagonal type or a twisted cubic structure instead of a cubic phase cubic structure.

A related art related to this is Korean Patent No. 10-0836035 entitled " Saturated and unsaturated lecithin-containing nanoemulsion and cosmetic composition containing the same ", which discloses a cosmetic composition containing a lecithin mixture as a surfactant, Or more of an oil or a physiologically active ingredient, and a water-containing nano emulsion having a water content of 10 to 500 nm, and a cosmetic composition containing the same. However, such a conventional technique is intended to promote transdermal absorption through the nanoemulsion, but does not form a cubic cubic structure.

Korean Patent No. 10-0844036, entitled "Cosmetic < RTI ID = 0.0 > Ingredient ", which combines polypropylene glycol or certain polar oil or polybutylene glycol with an ultraviolet absorber to alleviate skin irritation, Or polybutylene glycol, and a method for relieving irritation thereof. However, such a conventional technique does not form a cubic cubic structure.

In order to solve the problems of the prior art as described above, the present invention has the following objectives.

Firstly, the optimum conditions of the mixture and the compounding ratio of the mixture to the titanyl triol, glyceryl monooleate, phosphatidylcholine, and phosphatidyl ethanolamine as the lipid components forming the cubic cubic structure are provided,

Second, as typical active ingredients, adenosine, niacinamide, vitamins, idebanone, rasberatrol, and caffeine are encapsulated in a stabilized cubic cubic structure,

Third, a high-viscosity transparent cubic gel is made into a nano-emulsion using a dispersant,

Fourth, the nano emulsion containing the active ingredient forming the cubic cubic structure has excellent transdermal absorption ability,

Fifth, it is an object of the present invention to make it possible to apply the present invention to cosmetic, essence, lotion, and cream formulations of external skin preparations that maximize the efficacy of high-function cosmetics.

Other objects of the present invention will become readily apparent from the following description of the embodiments.

In accordance with an aspect of the present invention, there is provided a composition comprising 20 to 90% by weight of pyranetriol, 5 to 40% by weight of glyceryl monooleate, 3 to 25% by weight of phosphatidylcholine And 0.1 to 20% by weight of phosphatidylethanolamine. The composition for forming a cubic cubic structure is also provided.

The lipid base comprises 48 to 60% by weight of pyranetriol, 8 to 32% by weight of glyceryl monoolein, 10 to 22% by weight of phosphatidylcholine and 8 to 12% by weight of phosphatidylethanolamine May be mixed and formed.

According to another aspect of the present invention, there is provided a composition for forming a cubic cubic structure according to one aspect of the present invention, comprising 0.01 to 4% by weight of adenosine, 1 to 4% by weight of niacinamide , 0.01 to 4 wt% of ibebenone, 0.1 to 2 wt% of resveratrol, 0.1 to 5 wt% of vitamin A, 0.1 to 3 wt% of caffeine, and 0.1 to 2 wt% of alpha-lipoic acid Or a plurality thereof are compounded into a mixture.

In another aspect of the present invention, there is provided a process for preparing a cubic cubic structure, comprising: forming 0.1 to 2% by weight of a Pigment-60 hydrogenated castor oil as a dispersing agent, 0.1 to 2% by weight of a pigment / The emulsions formed using any one or both of the Fiji-98-67 copolymers can be obtained as bezurlo from 100 to 800 nm.

According to another aspect of the present invention, there is provided a process for preparing a cosmetic composition according to another aspect of the present invention, comprising the steps of: dissolving the lipid base in an oil capable of receiving the lipid base; Introducing the active ingredient into the hard gel while agitating the oil in which the lipid base is dissolved; Adding and dispersing a dispersant to the hard gelated product; Passing the dispersed resultant through a high-pressure mixer to form nanoparticles; And defoaming the resultant nanoparticles with a vacuum compressor.

According to the composition for forming a cubic cubic structure according to the present invention, the cosmetic composition using the same, and the method for producing the same, it is possible to provide an optimal cubic cubic structure and stably encapsulate the percutaneous absorption promoter using the same. It can provide a variety of formulations that give the maximum efficacy to the development of functional cosmetics. It can promote the excellent transdermal absorption by injecting adenosine, niacinamide, vitamins, idebanone, rasberatrol, and caffeine into the cubic cubic structure as effective ingredients. And thus can have a significantly higher efficacy.

1 is a perspective view illustrating a cubic cubic structure according to an embodiment of the present invention.
2 is a flow chart illustrating a method of manufacturing a cosmetic composition according to an embodiment of the present invention.
3 is an image in which adenosine is embedded in a cubic cubic structure according to an embodiment of the present invention.
Figure 4 is an electron micrograph of a cosmetic composition according to one embodiment of the present invention.
5 is a graph showing the results of X-ray analysis of the cosmetic composition according to one embodiment of the present invention.
6 is a graph showing the results of the elution amount for the cosmetic composition according to one embodiment of the present invention.
7 is a graph showing the results of percutaneous absorption of the cosmetic composition according to one embodiment of the present invention.
FIG. 8 is a graph showing the results of skin moisturizing effect on the cosmetic composition according to one embodiment of the present invention.
FIG. 9 is a graph showing the result of the amount of water-loss of the hard skin against the cosmetic composition according to one embodiment of the present invention.

The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated and described in detail in the drawings. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but is to be understood to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention, And the scope of the present invention is not limited to the following examples.

The definitions of the main foreign words used in the present invention are expressed as follows to clarify the understanding. A peritoneal absorption, a hexagonal structure, a cubic structure, lipids, a phytantriol, a glyceryl monoolein, a multi-lamella elastomer (multi -lamellar vesicle, phosphatidyl choline, phosphatidyl amine, adenosine, niacinamide, vitamin, idebenone, resveratrol, Caffeine, a high pressure microfluidizer, a poloxamer, a liposome, a niosome, a cubic cubic structure, a drug delivery system, Cubic lattice, hydrotrope, and the like are not mentioned, but it is understood that the chemical naming method of chemical, food and cosmetic is generally referred to. In the present invention, a cubic body which is stable by the optimum material and the material forming the cubic cubic structure is provided, so that the effective drug can be stably embedded.

1. Modeling cubic cubic structure

1 is a perspective view illustrating a cubic cubic structure according to an embodiment of the present invention.

As shown in FIG. 1, a cubic cubic structure (also referred to as cubosome) according to an embodiment of the present invention is formed to have a cubic shape such that the horizontal, vertical, and height are equal to 1: 1: So that the desired active ingredient can be sealed inside.

2. Selection of materials forming cubic cubic structure

The composition for forming a cubic cubic structure according to the present invention is a lipid component forming a cubic cubic structure and can contain highly intimate oil and water such as phytanetriol, glyceryl monoolein, phosphatidylcholine and phosphatidyl amine And a cubic lattice structure is formed in a stable manner. Until now, a single material has been used to form a cubic cubic structure, which is very poor in stability and difficult to commercialize because it is selectively formed only under very specific conditions.

The composition for forming a cubic cubic structure according to an embodiment of the present invention is a composition capable of forming a stable cubic-phase structure, comprising 20 to 90 wt% of pyranetriol, 5 to 40 wt% of glyceryl monooleate, 3 To 25% by weight of phosphatidylcholine and 0.1 to 20% by weight of phosphatidylethanolamine. The results of the experiment are shown in Table 1 below.

Cubic cubic structure material selection and condition setting Ingredients Experiment 1 Experiment 2 Experiment 3 Experiment 4 Experiment 5 Experiment 6 Peat triol 20 40 50 60 80 90 Glyceryl monooleate 40 20 30 20 10 5 Phosphatidylcholine 20 30 20 10 5 3 Phosphatidyl ethanolamine 20 10 10 10 5 2 Formation of structure Hexagonal Cubic Cubic Cubic Cubic Cubic Stability (50 ℃, 1 week) Good Good Good Good Good Good

In a composition for forming a cubic cubic structure according to an embodiment of the present invention, the lipid base may include, for example, 40 to 60 wt% of pyranetriol, 20 to 40 wt% of glyceryl monooleate, 15 to 25 wt% Petidyl choline and 1 to 20% by weight of phosphatidyl ethanolamine. More specifically, it may be a composition comprising 48 to 60% by weight of pyranetriol, 8 to 32% by weight of glyceryl monooleate , 10 to 22% by weight of phosphatidylcholine and 8 to 12% by weight of phosphatidylethanolamine. Also, a lipid base composed of a composition in which a mixture of phytanetriol, glyceryl monooleate, phosphatidylcholine and phosphatidylethanolamine are mixed in a weight ratio of 5: 3: 2: 1 can form an excellent cubic cubic structure have. Hereinafter, the composition for forming a cubic cubic structure according to the present invention will be referred to as cubo lipids.

3. Performance evaluation of high internal oil and water content

2 to 80% by weight of the lipid base listed above may be used, 5 to 60% by weight of the oil may be accommodated, and 5 to 94% by weight of water may be accommodated to form a strong viscous gel. In all of the above experimental conditions, the present invention uses the composition of Experiment 3 of Table 1 to evaluate storage capacity of oil and water of high internal temperature. The experimental results are shown in Table 2.

Ingredients Experiment 7 Experiment 8 Experiment 9 Experiment 10 Experiment 11 Experiment 12 The composition of Experiment 3
(Lipid base) One 10 30 50 70 80 Dimethicone 2CS 50 - - 10 - - Paraffin oil - 50 - - 10 - Cetyl hexanoate - - 50 - - 10 Purified water 49 40 20 40 20 10 Stability (50 ℃, 1 week) Good Good Good Good Good Good

Based on these results, it is possible to dissolve the water-soluble active ingredient or the active ingredient having the oil-solubility in the cubic cubic structure.

4. Manufacturing method of cosmetic composition

2 is a flow chart illustrating a method of manufacturing a cosmetic composition according to an embodiment of the present invention.

As shown in Figure 2, the method of making a cosmetic composition according to one embodiment of the present invention first comprises dissolving a lipid base of a composition for forming a cubic cubic structure according to one embodiment of the present invention in an acceptable oil (S11). At this time, the oil can be used in various ways, but dimethicone can be used as in this embodiment.

(S13) and the hard gelation (S14) by injecting the active ingredient while stirring the oil in which the lipid base is dissolved, for example, at 5 to 50 rpm (S12). In the present invention, an adenosine component is used as an effective ingredient. In addition, such a hard gel forms a transparent cubic-shaped cube, in which a dispersant such as a Pigment-60 hydrogenated castor oil and a Pigment / Pigment-98-67 copolymer, either alone or in combination, (S15). Then, the fine emulsion is passed through a high-pressure mixer to be fine nanoparticles at a level of 100 to 800 nm (S16) and stabilized (S17). According to the change of the manufacturing method, it is possible to change the number of passing times of the high-pressure mixer or to vary the size and formulation of the particles by changing the passage pressure of the sample.

Then, the resultant nanoparticles are stabilized by passing through a high-pressure mixer and defoamed with a vacuum compressor (S18) to finally complete a cosmetic composition of a cubic cubic structure.

Meanwhile, the cosmetic composition according to the present invention is characterized in that, when forming the cubic cubic structure according to the present invention, 0.1 to 2 wt% of a pigment-60 hydrogenated castor oil, 0.1 to 2 wt% The emulsion formed using any one or both of the% by weight of PPy / PPy-98-67 copolymer can be obtained as a bezel of 100 to 800 nm.

5. Cubic cubic structure inclusion of active ingredient

Examples 1 to 4, Comparative Example 1

The cubic cubic structure according to the present invention is the most suitable system for encapsulating the active ingredient and is shown in FIG. 3 and Table 3 below, enclosing the components niacinamide and idebanone, which are the ingredients that help to improve wrinkles. 3, a transparent hard gel was formed. On the other hand, in the composition for forming a cubic cubic structure according to the present invention. 0.01 to 4 wt% of adenosine, 1 to 4 wt% of niacinamide, 0.01 to 4 wt% of idenone, 0.1 to 2 wt% of resveratrol, 0.1 to 5 wt% The cosmetic composition may be formulated by mixing one or more selected from the group consisting of vitamin A in weight%, caffeine in 0.1-3 weight%, and alpha lipoic acid in 0.1-2 weight%. Table 3 below shows the stability of these components only with respect to niacinamide and idebenone, but it can be confirmed that similar effects can be exhibited with respect to the remaining components.

Compositions of cubic cubic structure inclusion of niacinamide and idebene Ingredients Example 1 Practical Example 2 Practical Example 3 Practical Example 4 COMPARATIVE EXAMPLE 1 (1) cubo-lipid 10.0 15.0 20.0 30.0 - (2) Dimethicone 5.0 5.0 5.0 5.0 5.0 (3) Niacinamide - 4.0 - 1.0 4.0 (4) Idebenon 0.01 - 4.0 2.0 - (5) Purified water 10.0 10.0 10.0 10.0 10.0 (6) Piggy-60 Hydrogeneti
De-caster oil 0.5 0.5 1.0 2.0 0.5 (7) Phage / Phi Phi-98-67
Copolymer - 0.5 - 1.0 - (8) Purified water 74.49 65.0 60.0 49.0 80.5 sub Total 100 100 100 100 100 Number of passes through high pressure mixer One 2 3 4 3 High pressure mixer passing pressure 10,000 psi 10,000 psi 10,000 psi 10,000 psi 10,000 psi Vacuum degassing complete complete complete complete complete Formation of Cubic Cubic Structure Formed Formed Formed Formed Not formed Particle Size (nm) 950 nm 450 nm 175 nm 120 nm 1200 nm Stability (4 ℃, 4 weeks) Good Good Good Good detach Stability (25 ℃, 4 weeks) Good Good Good Good detach Stability (40 ℃, 4 weeks) Good Good Good Good detach

The cubo-lipid was varied from 10 to 30% by weight. The concentration of niacinamide and idebene was 4 wt%, respectively, and cubic cubic structure was formed. In Comparative Example 1, cubic phase was not formed in the composition not containing cubopolipid, and the particle size was also as large as 1,200 nm. On the other hand, fine particles were produced at 120 to 950 nm in the case of using cubo-lipid.

6. Confirm electron microscope of cubic cubic structure

The composition of Example 2 was observed with an electron microscope and its structure was analyzed and shown in Fig. As shown in FIG. 4, it can be seen that a bead core of a spherical shape is seen, and the inside structure is formed by a small tube tube. In addition, it was confirmed by X-ray analysis that the distance was calculated to form a cubic phase.

7. Identification of cubic cubic structure by X-ray analysis

It was confirmed by X-ray analysis that a cubic cubic structure was formed with the composition of Example 2, and the results are shown in FIG. In FIG. 5 (a), it can be seen that a cubic phase appears when the drug is not encapsulated at the placebo peak. Fig. 5 (b) shows the absorption peak at the same distance as the placebo when 4% by weight of niacinamide is contained. In FIG. 5 (c), when 4 wt% of ibebenone is contained, the absorption peak appears at the same distance as the placebo. Therefore, the cubic cubic structure enclosed with niacinamide and idebanone can be proved to be a cubic structure because it coincides with the same distance as the placebo. The concentrations used here were used only as a result to confirm formation of the cubic cubic structure.

8. Percutaneous absorption assessment

As shown in Examples 5 to 8 and Comparative Example 2 in Table 4, the percutaneous absorption evaluation was typically evaluated by using adenosine encapsulated in a cubic cubic structure, and the results are shown in FIG.

Examples 5 to 8, Comparative Example 2

end. Measurement of Percutaneous Absorption Effect Using Enhancer Cell in vitro method)

Percutaneous absorption evaluation was evaluated by using adenosine encapsulated in a cubic cubic structure as a typical example. In this experiment, the percutaneous absorption effect was measured in Example 6.

Compositions for evaluating percutaneous absorption of cubic cubic structured adenosine Ingredients Practical Example 5 Example 6 Practical Example 7 Example 8 COMPARATIVE EXAMPLE 2 (1) cubo-lipid 10.0 15.0 20.0 30.0 - (2) Dimethicone 5.0 5.0 5.0 5.0 5.0 (3) Adenosine 0.01 2.0 3.0 4.0 2.0 (4) Purified water 10.0 10.0 10.0 10.0 10.0 (5) Phage-60 Hydrogeneti
De-caster oil 0.5 0.5 1.0 2.0 0.5 (6) < tb > < tb > - 0.5 - 1.0 - (7) Purified water 74.49 67.0 64.0 48.0 82.5 sub Total 100 100 103 100 100 Number of passes through high pressure mixer 3 3 3 3 3 High pressure mixer passing pressure 10,000 psi 10,000 psi 10,000 psi 10,000 psi 10,000 psi Vacuum degassing complete complete complete complete complete Formation of Cubic Cubic Structure Formed Formed Formed Formed Not formed Particle Size (nm) 165 nm 168nm 160 nm 135 nm 1100 nm Stability (4 ℃, 4 weeks) Good Good Good Good detach Stability (25 ℃, 4 weeks) Good Good Good Good detach Stability (40 ℃, 4 weeks) Good Good Good Good detach

In the evaluation method, 3 mL of a cubic cubic structure containing 2% of adenosine was added to an enhancer cell (12-4000, Agilent technologies) having a surface area of 4 cm ² . An enhancer cell containing a cubic cubic structure was placed in a vessel, and PBS having a pH of 7.0 was maintained at 37 using a solvent, followed by stirring at a rate of 100 rpm for 24 hours. The membrane used was a cellulose nitrate membrane (7184-004, Whatman international Ltd) with a pore size of 0.45 μm and 175 mL of PBS was added to the vessel. For sampling, 5 mL of PBS containing adenosine released from the vessel was removed at 2, 4, 6, 8, 10, 12, and 24 hours, and 5 mL of bare PBS was added. Sampling of the samples was also carried out at 2, 4, 6, 8, 10, 12, and 24 hours, and the PBS solution containing the released adenosine was measured at a wavelength of 200 to 400 nm. The results are shown in Fig.

As shown in FIG. 6, the amount eluted through the enhancer cell was 10.9 mg after 2 hours, 15.5 mg after 4 hours, 16.7 mg after 6 hours, 18.5 mg after 8 hours, 20.0 mg after 10 hours, 12 hours 22 mg after the elapsed time and 41.3 mg after 24 hours eluted, suggesting that the adenosine encapsulated in the cubic cubic structure is easily absorbed by the skin.

I. Evaluation of Percutaneous Absorption by Tape Stripping in-vivo method)

The percutaneous absorption evaluation by the tape stripping method indicates the amount of percutaneous absorption of adenosine in samples 1 to 20 of the percutaneous absorption test tapes. The results are shown in Fig. As shown in FIG. 7, in the case of the first sample analyzed by tape stripping on the skin existing at the outermost surface of the skin, 790 g, the sum of 2 to 5 samples was 187.8 g, and the sum of 6 to 10 samples was 68.18 g of adenosine was detected. The samples 1 to 10 correspond to the epidermis and a certain amount of the skin was absorbable. 98.05 g of the sample 11 to 15 and 40.18 g of the sample 16 to 20 were detected. As a result, it was confirmed that the cubic cubic structure containing adenosine penetrates into the dermal layer.

9. Moisture evaluation

The skin moisturizing ability was evaluated with a 2% cubic cubic structured adenosine sample and a control group. The skin moisturizing ability was measured with a simple aqueous solution for 4 weeks twice a day in the morning and evening. The results are shown in Fig. As shown in Fig. 8, the moisturizing effect of the control group showed a slight increase even after 4 weeks. However, in the group enclosed with the cubic cubic structure, it was found that the difference significantly increased. This is because adenosine is not a moisturizing agent, and skin absorption has not been achieved so much.

10. Assessment of water-loss (TEWL)

Assessment of the amount of light skin moisture loss is a measure of whether the skin is resilient and has a strong barrier. Adenosine weight 2% Cubic cubic structured sample and control group were used as a simple aqueous solution twice daily for 4 weeks in the morning and evening, and water loss was measured at intervals of one week. The results are shown in Fig. As shown in Fig. 9, it can be seen that the amount of water loss in the control group is slightly increased or decreased even after four weeks without significant change. However, it was found that the moisture loss of the epidermis was significantly decreased in the group enclosed with the cubic cubic structure. This can be attributed to the well-formed skin barrier that helps strengthen skin barrier.

11. Cubic cubic structure inclusion of active ingredient

Examples 9-13

For practical implementation of the present invention, more detailed description will be given through Examples 9 to 13 of Table 5. < tb > < TABLE > It encapsulates raspberries, vitamin A, caffeine, and alpha lipoic acid as active ingredients to be encapsulated inside the cubic cubic structure. The range of applied concentration is encapsulating lasveratrol in an amount of 0.01 to 3 wt%, vitamin A in an amount of 0.1 to 10 wt%, caffeine in an amount of 0.1 to 5 wt%, and alpha lipoic acid in an amount of 0.01 to 5 wt% This is the case here. Specifically, for reasons of ground, 1% by weight of lasveratrol, 2 to 5% by weight of vitamin A, 2 to 3% by weight of caffeine and 1 to 2% by weight of alpha-lipoic acid were encapsulated.

Encapsulation of active ingredient Ingredients Example 9 Example 10 Example 11 Practical Example 12 Example 13 (1) cubo-lipid 10.0 15.0 20.0 30.0 20.0 (2) Dimethicone 5.0 5.0 5.0 5.0 5.0 (3) Resveratrol 0.1 - - - 2.0 (4) Vitamin A - 5.0 - - 0.1 (5) Caffeine - - 0.1 - 3.0 (6) Alpha-lipoic acid - - - 0.1 2.0 (7) Purified water 10.0 10.0 10.0 10.0 10.0 (8) Piggy-60 Hydrogeneti
De-caster oil 0.5 0.5 1.0 2.0 0.5 (9) PIGGY / PIGGY-98-67
Copolymer - 0.5 - 1.0 - (10) Purified water 74.4 64.0 63.9 51.9 57.4 sub Total 100 100 100 100 100 Number of passes through high pressure mixer 3 3 3 3 3 High pressure mixer passing pressure 10,000 psi 10,000 psi 10,000 psi 10,000 psi 10,000 psi Vacuum degassing complete complete complete complete complete Formation of Cubic Cubic Structure Formed Formed Formed Formed Formed Particle Size (nm) 620 nm 293 nm 281 nm 239 nm 367 nm Stability (4 ℃, 4 weeks) Good Good Good Good Good Stability (25 ℃, 4 weeks) Good Good Good Good Good Stability (40 ℃, 4 weeks) Good Good Good Good Good

The present invention is not only a simple cubic phase but also a practical application step. Therefore, when the composition of the present invention is applied to a cosmetic formulation, it can have a far superior transdermal absorption effect than other comparative groups. Further, the present invention can be applied as a technique for sealing various active ingredients.

Although the present invention has been described with reference to the accompanying drawings, it is to be understood that various changes and modifications may be made without departing from the spirit of the invention. Therefore, the scope of the present invention should not be limited to the described embodiments, but should be determined by the scope of the appended claims and equivalents thereof.

Claims (5)

A lipid base formed by mixing phytotriol, glyceryl monooleate, phosphatidylcholine and phosphatidylethanolamine,
The lipid base comprises 48 to 60% by weight of pyranetriol, 8 to 32% by weight of glyceryl monooleate, 10 to 22% by weight of phosphatidylcholine and 8 to 12% by weight of phosphatidylethanolamine The composition for forming a cubic cubic structure, which is formed by mixing
0.01 to 4 wt.% Of idenone, 0.1 to 2 wt.% Of resveratrol, 0.1 to 5 wt.% Of adenosine, 1 to 4 wt.% Of niacinamide, 0.01 to 4 wt. Of vitamin A, 0.1 to 3 wt% of caffeine, 0.1 to 2 wt% of alpha-lipoic acid,
In the formation of the cubic cubic structure, 0.1-2 wt% of Pigment-60 hydrogenated castor oil, 0.1-2 wt% of a pigment / PPE-98-67 copolymer as a dispersing agent based on the total weight of the composition, Wherein the emulsion formed by using any one or both of the emulsified cosmetic composition and the cosmetic composition is obtained as a bezel of 100 to 800 nm. delete delete delete A method for producing a cosmetic composition according to claim 1,
Dissolving the oil in an oil capable of receiving the lipid base;
Introducing the active ingredient into the hard gel while agitating the oil in which the lipid base is dissolved;
Adding and dispersing a dispersant to the hard gelated product;
Passing the dispersed resultant through a high-pressure mixer to form nanoparticles; And
Defoaming the resultant nanoparticles with a vacuum compressor;
≪ / RTI >

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