KR101686998B1 - Silicone gel sheet dressing - Google Patents

Abstract

The present invention relates to a silicone gel sheet dressing, and more particularly to a skin adhesive layer. An inner support layer of the mesh structure; An inner adhesive layer and an outer protective layer are laminated in this order.

Description

[0001] Silicone gel sheet dressing [0002]

The present invention relates to a silicone gel sheet dressing and, more particularly, to a silicone gel sheet dressing using a mesh to improve its stretchability.

From small scars on the knees or elbows to large scars on the ground, such as burns or surgery, the accidents that happen in daily life cause various scars and scars on our bodies. It is fortunate to be able to hide in clothes, but the scars on the face, arms, and legs can make a bad impression or feel shameful, affecting interpersonal relationships and social life.

Scarring is caused when the dermis is damaged due to surgery or trauma, after collagen of the dermis is overproduced and the skin is thinned even after the wound heals. Types of scars include hypertrophic scars, keloids, wide spread scars, and depression scars. Abnormal scars include hypertrophic scars and keloids. These may protrude from the surface of the skin and may be itchy, scuffed or sore. The hypertrophic scars and keloids are similar to the protruding shapes, but the development process and prognosis are different. Surface scarring refers to scarring that is common after scarring or post-traumatic scarring because of the tension of the surrounding skin. The keloid is similar to an apparent hypertrophic scar, but the border between the scar surface is very irregular, hard, thick, does not decrease in size after 6 to 18 months, and grows beyond the damaged extent and can reach normal skin.

In many cases, scarring results in decreased tactile sensation, reduced elasticity, and reduced range of motion (when the scar is present at the joint site). In addition, scarring, especially in the face and hands, can also cause cosmetic problems. Therefore, a skin treatment agent capable of minimizing or eliminating scar formation is required.

The most common methods used to treat scars are laser therapy, surgical surgery, compression therapy, or steroid injections that inject collagenolytic enzymes. Steroids, however, are of concern for children and adolescents, as they may cause side effects. A method of using a silicone gel sheet dressing in a simpler and more practical manner has emerged.

The ideal silicone gel sheet dressing will seal the scar area, apply moderate pressure, maintain a wet environment between the scar and the silicone gel sheet dressing, and require a protective film from the outside. Adhesion should be excellent. In addition, it should prevent the scar area from drying, have the function of preventing the intrusion of bacteria, and should not adhere to the scar surface during the exchange and damage the skin tissue.

To address this need, a number of products have been developed and marketed and it has been demonstrated that the scar appearance is reduced when the silicone gel sheet dressing is properly used for a sufficiently long period of time.

Silicone gel compositions for scar reduction are already known. For example, US 5,741,509 is effective in reducing scarring or scarring, but in order to achieve noticeable results, the known compositions must be applied to the wound or scar for a long period of time. Specifically, the silicone gel should be used for several months each day for approximately 18 hours a day. These silicone polymers have to be applied to wounds or scars for a long time, and since they are in a liquid state, secondary dressing is also required.

Korean Patent No. 10-1202875 relates to a hydrophilic polyurethane foam dressing material including a mesh film. The mesh used herein is a film type and its use is to prevent the dressing from sticking to the skin. In the silicone gel sheet dressing, It differs from the intended use.

Therefore, basically, when silicone gel sheet dressing is attached to the scar area, it should have elasticity and elasticity so that it can be easily used for movement of muscles and joints. In addition, scar reduction and removal state can be easily observed from the outside, And can be an ideal silicone gel sheet dressing if it is easy to use and economical.

In order to solve the above problems, the present invention provides a silicone gel sheet dressing capable of treating skin scars.

It is also an object of the present invention to provide a silicone gel sheet dressing which is improved in stickiness, elasticity, elasticity, transparency and economical efficiency in providing a continuous moist environment to skin scars.

 To achieve these and other advantages and in accordance with the purpose of the present invention, as embodied and broadly described herein, An inner support layer of the mesh structure; An inner adhesive layer and an outer protective layer are laminated in this order.

In the present invention, the skin adhesive layer has a water blocking and sealing effect, and the inner adhesive layer has a function of bonding an inner supporting layer and an outer protecting layer.

Further, in the present invention, the skin adhesive layer and the inner adhesive layer are composed of a silicone gel component.

The silicone gel sheet dressing according to the present invention is characterized in that the viscosity of the silicone gel is such that the skin adhesive layer has a high viscosity and the inner adhesive layer has a low viscosity.

In addition, the present invention provides a silicone gel sheet dressing characterized in that the material of the mesh structure includes synthetic fibers such as polyester, nylon, polypropylene, or cotton.

Further, in the present invention, the outer protective layer may include silicon; Polyurethane; Polyester; Polyethylene; polystyrene; Polypropylene; Polyvinyl chloride; Polycarbonate; Polybutylene terephthalate; Polymethylmethacrylate; And a synthetic polymer film selected from the group consisting of polytetrafluoroethylene and polyimide.

Also, the present invention provides a silicone gel sheet dressing characterized in that the thickness of the silicone gel sheet dressing is 0.30 to 2.00 mm.

The silicone gel sheet dressing according to the present invention is advantageous in minimizing scarring.

In addition, the silicone gel sheet dressing according to the present invention improves the elasticity and elasticity of the curved scar site and improves the stickiness of the scar, so that the silicone gel sheet dressing can be maintained for a long time and can be easily reattached Feature.

Fig. 1 is a conceptual diagram showing that skin hydration is brought into close contact with the skin to regulate the formation of collagen involved in skin regeneration and scar formation
2 is a photograph showing the kind of scar to be applied
FIG. 3 is a conceptual diagram showing the timing of using the silicone gel sheet dressing in the wound healing process
4 is a conceptual diagram according to a preferred embodiment of the present invention.
5 is a schematic cross-sectional view of a silicone gel sheet dressing according to an embodiment
6 is a cross-sectional schematic diagram of Comparative Example 1
7 is a cross-sectional schematic diagram of Comparative Example 2
8 is a sectional schematic view of Comparative Example 3

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

The terms "about "," substantially ", etc. used to the extent that they are used herein are intended to be taken to mean an approximation of, or approximation to, the numerical values of manufacturing and material tolerances inherent in the meanings mentioned, Accurate or absolute numbers are used to help prevent unauthorized exploitation by unauthorized intruders of the referenced disclosure.

If the skin is damaged, it will cause scarring. The damage of the epidermal layer is almost recovered without scarring, but when the scar is deepened, scarring occurs. Blood in wound area is clotted, growth factor is activated and stimulates new tissue formation. After 2 to 3 weeks, a new tissue is created and the surface wounds heal. However, it takes several months for the skin dermis to recover and a new tissue to form, which can lead to scarring. Common scars are the result of wound healing, but this process can occur abnormally and can lead to hypertrophic scarring or keloids. Hypertrophic scars, unlike normal scars, are harder and protrude above the skin surface, reddish and irregular in surface. Though hypertrophic scars increase, they do not go beyond the scarring range and gradually disappear after 1 to 2 years, whereas keloids grow more wider over time than normal, but also invade normal skin.

Therefore, the use of silicone gel sheet dressing at the time of scarring prevents water and moisture evaporation, provides moderate light pressure, prevents contact with external contaminants, maintains wet state in closed space, and forms collagen formation It is possible to prevent the collagen overgrowth of the dermal layer.

The present invention relates to a release film (10); A skin adhesive layer 20; An inner support layer 30 of a mesh structure; Each of the constituent components of the silicone gel sheet dressing in which the inner adhesive layer 40 and the outer protective layer 50 are laminated in order will be described in more detail as follows.

The release film 10 is also referred to as release paper. When used, it is peeled off and surface treated to achieve the purpose. The release film 10 may be applied after removing the skin adhesive layer 20 from the outside when the skin adhesive layer 20 is applied to the skin. Since the skin adhesive layer 20 can not use a release film that is surface-treated with silicon only in view of its silicon nature, a fluorine-treated release film can be used.

The outer protective layer 50 may be formed of a material such as silicon, polyurethane, polyester, polyethylene, polystyrene, polypropylene, polyvinyl chloride, polycarbonate, polybutylene terephthalate, polymethyl methacrylate, polytetrafluoroethylene or polyimide A polyurethane film is most suitable in view of slipperiness, ease of control of physical properties, and the like. Polyurethane is a polymer substance having excellent heat resistance, abrasion resistance, solvent resistance and chemical resistance because it is a chain of polymer compounds having urethane bond as a main component. In addition, it can stretch well when stretched with a flexible polymer. Therefore, in the silicone gel dressing of the present invention, when the polyurethane film is used as the outer protective layer 50, it is excellent in stretchability and elasticity, and can be used on the bending part of the skin or the joint part, and is excellent in heat resistance, wear resistance, It is advantageous to form a physical protective film to protect the scar and it is transparent and it is possible to observe the scar reduction process and it is easy to control the physical properties.

The outer protective layer 50 is a waterproof film and also serves to prevent intrusion of bacteria and germs from the outside. The thickness of the outer protective layer 50 is appropriately selected in order to improve skin adhesion and moldability, and is generally 0.010 to 0.100 mm, preferably 0.015 to 0.035 mm.

The main component of the skin adhesive layer 20 and the internal adhesive layer 40 is a silicone gel. The silicone gel of the skin adhesive layer (20), which is in direct contact with the scar site, has a high viscosity and is excellent in adhesion so that adhesion to the skin, tightness and adhesion can be enhanced. Thus, it prevents moisture from coming out of the skin from being released to the outside, preventing the scar surface from becoming dry and always maintaining the wet state. These closed and wet states regulate collagen formation in the skin fibroblasts involved in skin regeneration and scar formation.

On the other hand, the inner adhesive layer 40 is also a silicone composition, but unlike the high viscosity silicone component of the skin adhesive layer located on the skin side, the inner adhesive layer is used as a low viscosity silicone component between the PU film and the mesh, . In order to attach PU film and silicone, it is necessary to use an adhesive. Acrylic adhesive and the like affects the silicon hardening, so the PU film and the mesh are bonded by using low viscosity silicon. In addition, since low-viscosity silicon has high compatibility with high-viscosity silicon between meshes and low viscosity, it has a function to improve workability as compared with the use of high viscosity silicon.

The high viscosity silicon is a two-part type

The components of Solution A are

Siloxanes and silicones, di-Me, vinyl group-terminated 10-20%; Siloxanes and silicones, mono (vinylgroup) -terminated 50 to 60%; Polydimethylsiloxane, methyl end-blocked 20 ~ 30%;

Platinum, 1,3-diethyl-1,1,3,3-tetramethyldisiloxane complexes <0.1%

The components of Solution B are

Siloxanes and silicones, di-Me, vinyl group-terminated 25-45%

Polydimethylsiloxane, methyl end-blocked 10-20%

Siloxanes and silicones, di-Me, Me hydrogen, hydrogen-terminated 5-10%

Siloxanes and silicones, di-Me, hydrogen, hydrogen-terminated 25-35%

.

Low-viscosity silicon is a two-part type

The components of Solution A are

Siloxanes and silicones, di-Me, vinyl group-terminated 50-60%; Siloxanes and silicones, mono (vinylgroup) -terminated 10-20%; Polydimethylsiloxane, methyl end-blocked 20 ~ 30%;

Platinum, 1,3-diethyl-1,1,3,3-tetramethyldisiloxane complexes <0.1%

The components of Solution B are

Siloxanes and silicones, di-Me, vinyl group-terminated 20-30%

Siloxanes and silicones, mono (vinyl group) -terminated 5 to 15%

Polydimethylsiloxane, methyl end-blocked 10-20%

Siloxanes and silicones, di-Me, Me hydrogen, hydrogen-terminated
5 to 15%

Siloxanes and silicones, di-Me, hydrogen, hydrogen-terminated 20-30%

.

Synthetic fibers such as polyester, nylon, and polypropylene or cotton may be used as the inner support layer 30 of the mesh structure between the upper and lower silicon gels. A mesh is a unit that generally represents the mesh size of a net, and is a relatively thin-walled structure with a very small hole, such as a tight mesh. There is no restriction on the constituent material of this network, but it is elastic and strong in the nature of physical structure. In addition, even if a sheet is attached with a hole like a net, the scar surface can be directly observed from the outside, and the degree of the treatment can be visually confirmed. In addition, since the high viscosity silicon and the low viscosity silicone used in the skin adhesive layer 20 and the inner adhesive layer 40 are bonded to each other through the mesh holes, the inner supporting layer 30 and the outer protective layer 50 are more strongly bonded Effect can be shown.

In addition, since the mesh structure can serve as a support so that the silicone gel sheet can maintain a sufficient shape, it is excellent in shape stability and is advantageous in curling and improving molding property upon removal of the release film 10 Can be obtained. Also, even if the attachment / detachment is repeated as necessary, since the shape (restoring force) and adhesive force of the present invention can be maintained, there is an economic advantage of reuse several times.

In addition, it has excellent elasticity due to its excellent structural properties, so it can maintain proper tensile strength and elasticity. Therefore, it is effective for treatment because it has excellent adhesion to the scar area even in a part of the joint where the curved skin surface or shape is difficult to maintain. In addition, since the mesh may have elasticity in all directions due to structural characteristics with repetitive holes, the use of the mesh structure may be large because these properties may require relatively little consideration of orientation when attaching the skin. However, when the mesh material is made of fibers, the stretchability in one direction may be larger due to the nature of the weaving method.

The mesh material, which is the inner support layer 30 of the mesh structure of the present invention, can use polyester synthetic fibers, and is a polymer containing ester bond as a condensation polymer of terephthalic acid and ethylene glycol. The major features of polyester fiber are strong mechanical strength, durability and thermoplasticity, good resilience, good brittleness, acid resistance, alkali resistance and chemical resistance. It is strong in material and excellent in restoring force against folding, so it is useful not only to serve as a silicone gel support but also to maintain the shape of silicone gel sheet dressing. Because it is durable and good resilience, it is also advantageous for repeated washing and reusable.

 Hereinafter, an embodiment of the present invention will be described.

Example

 A silicone gel sheet dressing having a total thickness of 0.47 mm was prepared by sequentially laminating a PET film, a high-viscosity silicone, a polyester mesh, a low-viscosity silicone, and a PU film (see Fig. 5)

Comparative Example 1

 A silicone gel sheet dressing having a total thickness of 0.43 mm was prepared by sequentially laminating a PE film, a silicone, a nonwoven fabric and a PU film (see Fig. 6)

Comparative Example 2

 A silicone gel sheet dressing having a total thickness of 0.77 mm was prepared by sequentially laminating a PET film, a silicone, a silicone film and a polyester (see Fig. 7)

Comparative Example 3

 A silicone gel sheet dressing having a total thickness of 0.48 mm was prepared by sequentially laminating a PE film, a silicone, and a PU film (see Fig. 8)

Test Methods

1. Probe tack (Adhesive force measurement method)

ASTM 2979-01 Method to record the maximum force applied when the probe is removed from the adhered surface of the specimen after starting the test by attaching the example, comparative examples 1, 2 and 3 to a metal plate having a certain size of circular holes The initial adhesion is shown.

2. Elongation

The degree of elongation of the object is indicated, and there may be a difference depending on the directionality.

            Elongation = (L-Lo) / Lo * 100

           <L: stretched length after test, Lo: length before test>

3. Form stability

The shape before removal and the degree of change in shape after removal of the release film (PET film or PE film) of Examples and Comparative Examples are shown.

4. Characteristics after adhesion to skin (curling, molding)

Examples are the measurement of the degree of wrinkling between the spaces when adhering to the curved surface depending on the phenomenon of drying of the ends after attaching to the skin, and the molding properties.

5. Resilience

Refers to the force that is restored to the initial state after stretching the embodiment, the comparative example, and the like in one direction.

As a result of the above test, the adhesion of the present invention (Example) was 112 g, which was much better than that of Comparative Example 1 (74.8 g), Comparative Example 2 (84.8 g) and Comparative Example 3 (74.4 g) Comparative Example 2 is as bad as 24%, Comparative Example 3 is as good as 120%, and likewise, Examples are as good as 90%. Elongation is associated with resilience as well as elasticity and plays an important role in skin adhesion.

 The morphological stability indicates the degree of morphological deformation of the Examples and Comparative Examples before and after the release film was removed. In Comparative Example 1, there was no change in the shape before and after the removal, and the shape stability was excellent. On the other hand, in Comparative Example 2, curling occurred and in Comparative Example 3, the bottom surface was curled upward. As shown in Example 1, there is almost no deformation of the shape of the embodiment, so that the shape stability is excellent. This can be varied depending on the presence or absence of the internal support layer of the mesh structure of the examples and the comparative example and the characteristics of the material. The examples have a mesh structure of polyester, and the comparative example 1 includes a nonwoven fabric. It is found that the shape stability is much better.

Whether or not the adhesive force is excellent can be seen from the form of the example after the attachment to the skin and the form of the comparative example. Curling refers to the phenomenon that the end of the product dries easily and dries with the skin after attachment. In Comparative Example 2, as shown in the table, one side was severely curled, and in Comparative Example 3, both edges were curled more severely. As shown in the table, Comparative Example 2 has the greatest number of wrinkles, and Comparative Examples 1 and 3 show a slight folding around the end portion. On the other hand, it can be seen that the embodiment is perfectly close to the curved surface.

The restorative force refers to the force to return to the original state after the product is increased. As shown in the table, the restorative force is not meaningful since Comparative Example 1 has no extensibility itself, and Comparative Examples 2 and 3 have a restorative force after the increase. However, It is difficult to restore to the original state due to the phenomenon. However, it can be seen that the embodiment is restored to its original state after the increase.

As a result, the silicone gel sheet dressing of the present invention is excellent in elongation and restoring force, unlike the other comparative examples, due to the characteristics of a mesh structure in the form of a polyester knitted fabric, and the mesh structure is also advantageous in terms of shape stability, . In addition, due to the nature of the mesh structure hole, the adhesion between the high viscosity and low viscosity silicon is enhanced, and the silicone gel having transparency and easy adhesion to scars, high viscosity and high adhesive strength are excellent in adhesion. Therefore, unlike the comparative examples, it is easy to adhere to the curved surface due to high elongation and restoring force, and there is no phenomenon of curling or wrinkling after the adhesion. It is excellent in economical efficiency because it is easy to reuse after washing because it is excellent in restoring ability to return to the original state after the removal.

10: release film 20: skin adhesive layer
30: inner support layer of the mesh structure 40: inner adhesive layer
50: outer protective layer 60: nonwoven fabric
70: Film 80: Fabrics (Polyester)

Claims (7)

Skin adhesive layer;
An inner supporting layer having a uniform mesh structure and elasticity and elasticity;
An inner adhesive layer and an outer protective layer are stacked in this order,
Wherein the skin adhesive layer and the inner adhesive layer are made of a silicone gel component,
Wherein the viscosity of the silicone gel is high viscosity of the skin adhesive layer and low viscosity of the inner adhesive layer.
The method according to claim 1,
Wherein the skin adhesive layer has a wetting property, a close adhesion and an airtight effect, and the inner adhesive layer has a function of bonding an inner supporting layer and an outer protective layer.
delete delete The method according to claim 1,
Wherein the material of the mesh structure includes synthetic fibers such as polyester, nylon, and polypropylene, or a cotton material.
The method according to claim 1,
Wherein the outer protective layer comprises silicon; Polyurethane; Polyester; Polyethylene; polystyrene; Polypropylene; Polyvinyl chloride; Polycarbonate; Polybutylene terephthalate; Polymethylmethacrylate; A synthetic polymer film selected from the group consisting of polytetrafluoroethylene and polyimide.
The method according to claim 1,
Wherein the thickness of the silicone gel dressing sheet is 0.30 to 2.00 mm.

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