KR101668373B1 - Re-expansible stent and treatment apparatus using it - Google Patents

Re-expansible stent and treatment apparatus using it Download PDF

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Publication number
KR101668373B1
KR101668373B1 KR1020150081517A KR20150081517A KR101668373B1 KR 101668373 B1 KR101668373 B1 KR 101668373B1 KR 1020150081517 A KR1020150081517 A KR 1020150081517A KR 20150081517 A KR20150081517 A KR 20150081517A KR 101668373 B1 KR101668373 B1 KR 101668373B1
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KR
South Korea
Prior art keywords
stent
shape memory
memory alloy
alloy wire
shape
Prior art date
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KR1020150081517A
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Korean (ko)
Inventor
김철생
박찬희
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전북대학교산학협력단
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Priority to KR1020150081517A priority Critical patent/KR101668373B1/en
Priority to PCT/KR2016/005933 priority patent/WO2016200103A1/en
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Publication of KR101668373B1 publication Critical patent/KR101668373B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/94—Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol

Abstract

Provided are a re-expansible stent, and a treatment device using the same. According to an embodiment of the present invention, a re-expansible stent comprises: a first stent having a shape of a cylindrical mesh prepared by weaving a first shape-memory alloy wire into a lattice type structure; and a second stent prepared by weaving a second shape-memory alloy wire with the first stent to have a helical structure. The second shape-memory alloy wire returns to an original shape at a temperature higher than the temperature of the first shape-memory alloy wire.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stent capable of re-

The present invention relates to a stent capable of re-expanding, and a treatment apparatus using the stent. More particularly, the present invention relates to a stent capable of expanding a narrowed passage due to re-expansion of a stent, The present invention relates to a stent capable of expanding and a treatment apparatus using the stent.

In general, the lumens in the human body may be impaired in function due to stenosis or severely impaired in function. For example, the blood circulation is not performed well due to arteriosclerosis, or esophageal cancer is narrowed by esophageal cancer.

Thus, a stent is used as a mechanism for expanding the lumen narrowed by the stenosis and preventing the progress of the stenosis. Such a stent is known to have various structures, and a cylindrical wire structure is generally used in which a wire is wound in a specific manner to form a peak portion and a valley portion along the circumference.

1 is a front view showing an example of a conventional stent.

1, the stent 1 is manufactured by using a jig (not shown) or the like. For example, the jig may have a groove longitudinally formed at an equiangular position on the circumference of a cylindrical body, And the wire 2 is knotted to each pin so as to be bent in a bending form so as to manufacture a hollow cylindrical stent 1. [

The hollow cylindrical cylindrical stent 1 is inserted into a desired position of the stent insertion device, and the stent 1 inside the stent insertion device is taken out to be installed at a desired lesion site. The stent (1) is inserted into the lesion site and pushes the lesioned part outwardly to expand the passage of the lumen.

However, even if the stent 1 is inserted and installed, the tumor and the like may grow again, and the lumen of the human body may be restenosed. In such a case, various problems may occur, such as re-operation of the stent 1.

Korea Patent Publication No. 2011-0057514 (Published on June 1, 2011) Korean Patent Laid-Open Publication No. 2013-0106115 (published on September 27, 2013) Korea Patent Publication No. 2015-0051646 (published on May 13, 2015)

In order to solve the above problems, the present invention provides a stent capable of expanding a narrowed passage due to restenosis by re-expanding the stent when the lumen in the human body is restenosed after the stent is inserted, and a treatment apparatus using the stent. to provide.

The problems to be solved by the present invention are not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

According to an aspect of the present invention, there is provided a re-expandable stent comprising: a first stent in the form of a cylindrical mesh formed by weaving a first shape memory alloy wire into a lattice structure; And a second stent formed by weaving a second shape memory alloy wire, which is circularly restored at a higher temperature than the first shape memory alloy wire, into a spiral structure in the first stent.

The first shape memory alloy wire may be a Nitinol shape memory alloy which is restored to a circular shape at 36 to 38 占 폚.

The second shape memory alloy wire may be a Nitinol Shape Memory alloy which is restored to a circular shape at 39 to 45 ° C.

According to another aspect of the present invention, there is provided a stent capable of re-expanding, comprising: a cylindrical stent-shaped first stent formed by weaving a first shape memory alloy wire having a shape memory temperature at a living body temperature in a lattice- ; And a second stent formed by weaving a second shape memory alloy wire having a shape memory temperature higher than the living body temperature in the longitudinal direction on the outer circumferential surface of the first stent.

The second stent may be formed by weaving a plurality of strands on the outer circumferential surface of the first stent.

In addition, the lengths of the second stents may be different from each other.

In addition, the second stent may have different distances between adjacent stents.

The temperature of the shape memory may be different from that of the second stent.

According to another aspect of the present invention, there is provided a treatment device using a re-expandable stent, comprising: a stent of a re-expandable stent according to any one of the above embodiments; And an electromagnetic field generator for applying an electromagnetic field to the second shape memory alloy wire to re-expand the stent.

Other specific details of the invention are included in the detailed description and drawings.

According to the present invention, if the lumen in the human body is restenosed after stent insertion, the stent can be re-inflated to expand the narrowed passage due to restenosis.

1 is a front view showing an example of a conventional stent.
2 is a cross-sectional view of a stent capable of re-expansion according to an embodiment of the present invention.
3 to 6 are front views showing various examples of a stent capable of re-expanding according to another embodiment of the present invention.
7 is a conceptual diagram of a treatment apparatus using a stent capable of re-expansion.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Is provided to fully convey the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout the specification.

Although the first, second, etc. are used to describe various elements, components and / or sections, it is needless to say that these elements, components and / or sections are not limited by these terms. These terms are only used to distinguish one element, element or section from another element, element or section. Therefore, it goes without saying that the first element, the first element or the first section mentioned below may be the second element, the second element or the second section within the technical spirit of the present invention.

The terminology used herein is for the purpose of illustrating embodiments and is not intended to be limiting of the present invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. As used herein, the terms "comprises" and / or "made of" means that a component, step, operation, and / or element may be embodied in one or more other components, steps, operations, and / And does not exclude the presence or addition thereof.

Unless defined otherwise, all terms (including technical and scientific terms) used herein may be used in a sense commonly understood by one of ordinary skill in the art to which this invention belongs. Also, commonly used predefined terms are not ideally or excessively interpreted unless explicitly defined otherwise.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

2 is a cross-sectional view of a stent capable of re-expansion according to an embodiment of the present invention.

Referring to FIG. 2, a re-expandable stent 10 according to an embodiment of the present invention includes a first stent 11 in the form of a cylindrical mesh formed by weaving a first shape memory alloy wire into a lattice structure, And a second stent 12 formed by weaving a second shape memory alloy wire, which is circularly restored at a temperature higher than that of the first shape memory alloy wire, in a spiral structure in the first stent 11. The second stent 12 is woven on the first stent 11 and the shape memory temperature of the second shape memory alloy wire of the second stent 12 is higher than that of the first shape memory alloy wire of the first stent 11 When heat is applied to the second stent 12, expansion to the first stent 11 can be achieved by circular restoration of the second stent 12.

First, the first stent 11 is formed by weaving a first shape memory alloy wire in a lattice-like structure, and may have a cylindrical mesh shape with a hollow. Here, the first shape memory alloy wire of the first stent 11 is preferably made of a nitinol shape memory alloy which is restored to a circular shape at 36 to 38 占 폚.

Nitinol shape memory alloy is an alloy of nickel (Ni) and titanium (Ti). Even if deformed, it is restored to its original shape when heated above a certain temperature. The first shape memory alloy wire is a nitinol shape memory alloy in which the wire is restored to a circular shape at 36 to 38 占 폚 and thus has a property of maintaining a circular shape in the lumen of the human body. The process of forming the first stent 11 is not shown in the drawing, but a cylindrical structure having a hollow therein is formed using a normal jig.

Next, the second stent 12 is formed by weaving the second shape memory alloy wire into the first stent 11 in a spiral structure. That is, after the first shape memory alloy wire is knitted into a lattice structure to form a first stent 11, a second shape memory alloy wire is spirally formed on the first stent 11 to form a first stent 11 The second stent 12 is surrounded by the second stent 12. Although the process of forming the second stent 12 is not shown in the drawing, the second stent 12 is wrapped around the first stent 11 using a conventional jig so that the second shape memory alloy wire is spirally wound All. The second stent 12 having a spiral structure can be woven on the first stent 11 having the lattice structure and the stent 10 capable of re-expanding with only one jig can be made.

Here, the second shape memory alloy wire of the second stent 12 is preferably made of a nitinol shape memory alloy which is restored to a circular shape at 39 to 45 캜. Since the shape memory temperature of the second shape memory alloy wire is 39 to 45 캜 and the shape memory temperature of the first shape memory alloy wire is 36 to 38 캜, heat is applied to the stent 10 capable of re- When the temperature is raised to about 45 DEG C, the second stent 12 is re-expanded. In addition, the first stent 11 can expand like the second stent 12 due to the re-expansion of the second stent 12.

3 to 6 are front views showing various examples of a stent capable of re-expanding according to another embodiment of the present invention.

3 to 6, a stent 20 capable of re-expansion according to another embodiment of the present invention includes a cylindrical shape wire 20 formed by weaving a first shape memory alloy wire having a shape memory temperature at a living body temperature in a lattice- And a second stent (22) formed by weaving a second shape memory alloy wire having a shape memory temperature higher than the living body temperature on the outer circumferential surface of the first stent (21) in the longitudinal direction do. The second stent 22 is woven in the longitudinal direction on the first stent 21 and the shape memory temperature of the second shape memory alloy wire of the second stent 22 is greater than the shape memory temperature of the first shape memory alloy The wire can be expanded to the first stent 21 by the circular restoration of the second stent 22 when heat is applied to the second stent 22.

First, the first stent 21 is formed by weaving the first shape memory alloy wire in a lattice-like structure, and may have a cylindrical mesh shape with a hollow. Here, the first shape memory alloy wire of the first stent 21 is preferably made of a shape memory alloy which is restored to its original shape at a living body temperature, for example, about 36 to 38 DEG C. As described above, the first stent 21, which is a cylindrical mesh structure having a hollow inside, is formed by using a normal jig.

Next, the second stent 22 is formed by weaving the second shape memory alloy wire in the longitudinal direction on the outer peripheral surface of the first stent 21. The second stent 22 can be woven in the longitudinal direction of the first stent 21 having the lattice structure and the second shape memory alloy wire having the shape memory higher than the living body temperature is heated, And the first stent 21 is similarly expanded, so that the stent 10 which can be re-expanded can be made. At this time, when the second stent 22 is woven into the first stent 21 in the longitudinal direction, the second shape memory alloy wire may be woven in a curved shape as well as a straight shape.

Here, it is preferable that a plurality of second stents 22 are formed on the outer circumferential surface of the first stent 21. The second stent 22 is woven in the longitudinal direction on the outer circumferential surface of the first stent 21 so that the second stent 22 does not surround the end surface of the first stent 21 but the second stent 22, Only a part of the end surface of the first stent 21 is enclosed. Therefore, when restoring the circular shape of the second stent 22, the pulling force of the first stent 21 can be adjusted according to the number of the second stent 22.

Further, the lengths of the second stent 22 may be different from each other. When a plurality of second stents 22 are woven on the outer circumferential surface of the first stent 21, the length of the second shape memory alloy wire constituting the second stent 22 is made different, Direction.

In addition, the second stent 22 may have different distances between adjacent stents. When a plurality of second stents 22 are woven on the outer circumferential surface of the first stent 21, the distance between the second shape memory alloy wires constituting the second stent 22 is made different, It can be woven in the longitudinal direction. When a plurality of second stents 22 are woven on the outer circumferential surface of the first stent 21, the shape memory temperatures of the second shape memory alloy wires constituting the second stent 22 are made different, And can be woven in the longitudinal direction on the outer circumferential surface.

The second stent 22 may have different shape memory temperatures. For example, assuming that the shape memory temperatures of the respective second shape memory alloy wires constituting the second stent 22 are 39, 40, 41, 42, 43, 44, 45 ° C, Are staggered in the longitudinal direction on the outer circumferential surface of the first stent (21), the respective second shape memory alloy wires can be sequentially restored to the circular shape according to the heating time.

By varying the length, spacing distance, shape memory temperature, etc. of each of the second stents 22, the expansion restoring force of the stent 20 that can be re-expanded can be appropriately designed according to the size and shape of the lumen.

7 is a conceptual diagram of a treatment apparatus using a stent capable of re-expansion.

Referring to FIG. 7, the treatment device using the re-expandable stent is configured to apply an electromagnetic field to the second shape memory alloy wire of the stent 10, 20 and the second stent 12, 22 capable of re- And an electromagnetic field generator (50) for re-expanding the expandable stents (10, 20).

For example, as shown in FIG. 7, when a tumor 7 occurs in the digestive organs 5, the stent 10 is inserted to secure the passage of the organ 5, Repopulation causes restenosis of the organ (5). At this time, the second shape memory alloy wire can be heated by applying an electromagnetic field M to the stent 10. When the temperature reaches the shape memory temperature of the second stent 12, 22, the second stent 12, Is restored to its original shape. The first stent 11, 21 woven with the second stent 12, 22 also expands, so that the stent 10, 20 pushes the tumor 7.

Therefore, even if the tumor 7 is again proliferated and the organ 5 is restenosed, heat is applied to the shape memory alloy wire without re-performing the stent 10, 20, so that the stent 10, By expanding, the narrowed passage can be enlarged.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

10, 20: Re-expandable stent
11, 21: first stent 12, 22: second stent
50: electromagnetic field generator

Claims (9)

A first stent in the form of a cylindrical mesh formed by weaving a first shape memory alloy wire in a lattice structure; And
And a second stent formed by weaving a second shape memory alloy wire that is circularly restored at a higher temperature than the first shape memory alloy wire in a spiral structure in the first stent. The method according to claim 1,
Wherein the first shape memory alloy wire
A natinol shape memory alloy that is restored to its original shape at 36 to 38 占 폚. The method according to claim 1,
Wherein the second shape memory alloy wire
A natinol shape memory alloy that is restored to its original shape at 39 to 45 ° C. A first stent in the form of a cylindrical mesh formed by weaving a first shape memory alloy wire having a shape memory temperature at a living body temperature in a lattice structure; And
And a second stent formed by weaving a second shape memory alloy wire having a shape memory temperature higher than the living body temperature in the longitudinal direction on the outer circumferential surface of the first stent. 5. The method of claim 4,
Wherein the second stent comprises:
Wherein a plurality of stents are formed by weaving on the outer circumferential surface of the first stent. 6. The method of claim 5,
Wherein the second stent comprises:
A stent with re-expansion that is different in length from each other. 6. The method of claim 5,
Wherein the second stent comprises:
A stent that is re-expandable with different spacing between adjacent stents. 6. The method of claim 5,
Wherein the second stent comprises:
Stent with re-dilatation with different shape memory temperatures. 9. A stent according to any one of claims 1 to 8, And
And an electromagnetic field generator for applying an electromagnetic field to the second shape memory alloy wire to re-expand the stent.
KR1020150081517A 2015-06-09 2015-06-09 Re-expansible stent and treatment apparatus using it KR101668373B1 (en)

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PCT/KR2016/005933 WO2016200103A1 (en) 2015-06-09 2016-06-03 Re-expandable stent, and treatment apparatus using same

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KR20200024430A (en) * 2018-08-28 2020-03-09 인제대학교 산학협력단 Stent structure and surgical instrument for stent including the structure
WO2023120890A1 (en) * 2021-12-24 2023-06-29 전북대학교산학협력단 Shape-memory wire-braided re-expandable stent
WO2023128148A1 (en) * 2021-12-31 2023-07-06 전북대학교산학협력단 Re-expandable stent comprising multiple shape memory wires
KR20230140838A (en) 2022-03-30 2023-10-10 가천대학교 산학협력단 A blood flow sensing vascular external stent

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JP2022541194A (en) * 2019-07-16 2022-09-22 マイクロベンション インコーポレイテッド Medical device with improved shape characteristics
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WO2023120890A1 (en) * 2021-12-24 2023-06-29 전북대학교산학협력단 Shape-memory wire-braided re-expandable stent
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WO2023128148A1 (en) * 2021-12-31 2023-07-06 전북대학교산학협력단 Re-expandable stent comprising multiple shape memory wires
KR20230103109A (en) * 2021-12-31 2023-07-07 전북대학교산학협력단 Re-expansion stent comprising a plurality of shape memory wires
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KR20230140838A (en) 2022-03-30 2023-10-10 가천대학교 산학협력단 A blood flow sensing vascular external stent

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