KR101653888B1 - Passive type trans-sacral implanted epidural pulsed radio frequency stimulator for spinal cord stimulation - Google Patents

Abstract

The present invention relates to a passive-type inhaler which is capable of controlling the generation of pulsatile high-frequency waves generated by an appropriate algorithm according to the patient's symptoms and the generated pulsatile high-frequency energy to the patient's or neurological disorders The present invention relates to a pulsatile high frequency stimulation device, which can select a pulsatile high frequency signal according to a patient condition, convert a selected pulsatile high frequency signal into a therapeutic pulsatile high frequency signal, convert it into a wireless form, A high frequency signal generating device; And an electrode for receiving the therapeutic pulsatile high frequency signal through the antenna of the passive implantable catheter inserted into the body of the patient to generate electrical stimulation at the corresponding site. In addition, two passive implantable catheters can be inserted into the body to service the synchronized mode for the stimulation synchronization of two passive implantable catheters to stimulate the desired spinal nerve section. Therefore, it is effective not only to alleviate the patient's pain or nervous anxiety, but also to improve the neuromodulation treatment for the pain treatment or the nerve abnormality.

Description

[0001] The present invention relates to a passive type trans-sacral implanted epidural pulsed radio frequency stimulator for spinal cord stimulation for catheter-

The present invention relates to a pulsatile high-frequency stimulation device for catheter (hereinafter, referred to as passive catheter-based high-frequency stimulation device) for passive spinal nerve stimulation of a passive bioimplant, and more particularly, The present invention relates to a passive ex vivo pulsatile high-frequency stimulation device for delivering to a transplanted catheter in order to control pain or nerve dysfunction with the generated pulsatile high-frequency energy, thereby enabling a patient to control pain or nerve dysfunction.

Pulsatile high frequency has been used for the treatment of various chronic pain syndromes. It has recently been shown to be a neuro-modal therapy device because it has almost no nerve damage compared to persistent high frequency. In addition, it can be considered as a tool to avoid steroid injections that can cause various complications due to repeated injections in elderly patients with chronic pain diseases. The patients who had undergone pulsatile radiofrequency in the cervical spine, lumbar spinal ganglion, and spinal submandibular ganglion were diagnosed as chronic refractory neuropathic pain, which was satisfactory for various medications, trigeminal neuralgia, spinal cord postoperative failure syndrome, complex regional pain syndrome For the treatment of postherpetic neuralgia, peripheral nerve pulsatile high frequency treatment of the spinal nerve, face, trunk, and limb is increasing. Recently, it has been reported that pulsatile high-frequency in the joint is effective to reduce chronic joint pain. The pulsatile high frequencies in the joints are thought not to act directly on the nervous tissue, but to act on the tissues of the joints to control anti-inflammatory and immune cell functions.

When pulsatile high frequency is applied to the dorsal root ganglion of an animal causing neuropathic pain using an animal model to escape from the nucleus pulposus, microcystic cells (dorsal root ganglion), which is known to be important for the expression of nerve pain in the dorsal horn, microglia, astrocyte, substance P, and the like are decreased. When pain is sustained in the peripheral nerves or joints, the pain sensation of the central nervous system, such as the spinal cord and the brain, becomes sensitized, leading to central sensitization, which leads to activation of microcysts and the like. When central sensitization occurs, the local pain gradually expands and the pain spreads to the wide area, and even the small stimulus causes the pain or the spontaneous pain to become worse and it does not react well to any treatment.

In order to fundamentally reduce such intractable pain, pulsatile high frequency therapy is needed to reduce the activity of microglial cells. In order to treat the spread of the central nervous system, pulsatile high - frequency treatment of the nerves across the whole spinal cord is necessary because it is not responsive to the monotonic pulsatile radiofrequency treatment for local nerves. In addition, even if responding to this epidural spinal nerve pacing pulsatile radiofrequency treatment, pain reduction or neuropathy control effect does not persist for a long time. Therefore, the insertion of a bio-implantable catheter, A stimulation device is required.

It has been reported that a low frequency electric stimulation of 30 ~ 150Hz is used in the conventional insertion type spinal nerve stimulation, but recently, a 10,000Hz electric stimulator has been developed to give better treatment results.

However, by stimulating the high frequency of 500,000Hz, which is better than the low-frequency stimulation, with the pulsatile stimulation, it is possible to treat chronic intractable pain treated with centrally sensitized spinal cord, A pulsatile high frequency device for a catheter for spinal nerve stimulation has become necessary.

Korean Patent No. KR 10-1012818 U.S. Published Patent Application No. 2013-0035745 Korean Patent Publication No. 10-2013-0109274 Korean Patent Publication No. 10-2011-0066460

In order to solve such a problem, the present invention provides a method for delivering pulsatile high-frequency waves generated by an appropriate algorithm according to a patient's symptoms and pulsatile high-frequency energy generated to a catheter so as to control pain or nerve disorders, The present invention provides an in vitro ex vivo pulsatile high frequency stimulation device for a passive catheter.

The ex vivo pulsatile high frequency stimulation apparatus for a passive catheter according to an embodiment of the present invention allows selection of a pulsatile high frequency signal according to a patient condition and converts the selected pulsed high frequency signal information into a therapeutic pulsatile high frequency signal, A therapeutic sheath high frequency signal generating device for transmitting the converted signal through an antenna; And a passive implantable catheter that receives the therapeutic beating high-frequency signal through an antenna implanted in the body and generates electrical stimulation at the corresponding site.

As an embodiment related to the present invention, a treatment beating high-frequency signal generating device is provided to select a frequency necessary for pain or neurological disorder control treatment, and a treatment is performed based on frequency information selected by a physical force externally applied Frequency signal generation request signal from the input unit, and outputs a therapeutic initial signal when the therapeutic-use pulsatile high-frequency signal generation request signal is input from the input unit, while the pulsatile high-frequency signal generation unit generates the pulsatile high-frequency signal A pulse generating high frequency signal generating unit for generating and outputting a predetermined pulsatile high frequency signal in response to a control of the control unit; and a control unit for receiving a therapeutic initial signal from the control unit and inputting the pulsatile high frequency signal information from the pulsatile high frequency signal generating unit After mixing, , A pulsatile high frequency power amplifier for receiving and amplifying the therapeutic electric signal from the pulsatile high frequency gateway, and a pulse-like high frequency power amplifying part for converting the amplified therapeutic electric signal into a pulsatile high frequency And a wireless power control unit for transmitting the signal through an antenna.

As an embodiment related to the present invention, in order to stimulate a desired spinal nerve section by inserting two passive bio-implantable catheters into the body, two therapeutic beating high frequency signal generating apparatuses for synchronization of stimulation of two passive bio- Can be serviced in synchronous mode.

As an embodiment related to the present invention, the input unit can be provided to select a duration and a treatment time of a frequency when selecting a frequency required for pain treatment.

As an embodiment related to the present invention, a control unit provides a plurality of patient condition information through an input unit, and when one patient condition information of the patient condition information is selected, a service frequency, a duration, So that an interface screen is provided.

As an embodiment related to the present invention, the therapeutic pulsatile high-frequency signal generating apparatus further includes a storage unit for storing a plurality of patient state information and a plurality of patient state information linked with duration and treatment time information, The information stored in the storage unit can be read and provided through the input unit.

As an embodiment related to the present invention, the input unit may be provided in the form of a touch screen.

As an embodiment related to the present invention, the radio power control unit may perform high-frequency matching with an antenna connected to an electrode, and monitor the output state of the therapeutic beating high-frequency signal transmitted through the antenna.

As an embodiment related to the present invention, it is possible to receive a therapeutic beating high frequency signal through an antenna of a passive implantable catheter implanted in the body, and to generate electric stimulation at a corresponding site.

According to the present invention, the generation of pulsatile high-frequency waves and the generated pulsatile high-frequency energy according to the patient's symptoms are transmitted to a catheter implanted in the body so as to control pain or nerve dysfunction, It has the effect of alleviating pain and nervous anomalies.

Further, the present invention can generate and transmit a pulsatile high-frequency signal necessary for treatment non-invasively in vitro, thereby eliminating unnecessary pain generated when a high-frequency needle is inserted into a patient, It is effective to control and treat pain and nerve disorders.

1 is a block diagram for explaining a configuration of an extracorporeal pulsatile high frequency stimulation apparatus for a passive catheter according to the present invention.
FIGS. 2 to 8 are views for explaining the results of treatment by the in vitro pulsatile high frequency stimulation apparatus to which the present invention is applied.

It is noted that the technical terms used in the present invention are used only to describe specific embodiments and are not intended to limit the present invention. In addition, the technical terms used in the present invention should be construed in a sense generally understood by a person having ordinary skill in the art to which the present invention belongs, unless otherwise defined in the present invention, Should not be construed to mean, or be interpreted in an excessively reduced sense. In addition, when a technical term used in the present invention is an erroneous technical term that does not accurately express the concept of the present invention, it should be understood that technical terms can be understood by those skilled in the art. In addition, the general terms used in the present invention should be interpreted according to a predefined or prior context, and should not be construed as being excessively reduced.

Furthermore, the singular expressions used in the present invention include plural expressions unless the context clearly dictates otherwise. In the present invention, terms such as "comprising" or "comprising" and the like should not be construed as encompassing various elements or stages of the invention, Or may further include additional components or steps.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings, wherein like reference numerals refer to like or similar elements throughout the several views, and redundant description thereof will be omitted.

In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail.

It is to be noted that the accompanying drawings are only for the purpose of facilitating understanding of the present invention, and should not be construed as limiting the scope of the present invention with reference to the accompanying drawings.

1 is a block diagram for explaining a configuration of an extracorporeal pulsatile high frequency stimulation apparatus for a passive catheter according to the present invention. FIGS. 2 to 8 are views for explaining the results of treatment by the in vitro pulsatile high frequency stimulation apparatus to which the present invention is applied.

As shown in FIG. 1, the in vitro external pulsatile high frequency stimulation device for a passive catheter comprises a therapeutic beating high frequency signal generator 200 and a passive implantable catheter 300.

The therapeutic pulsatile high-frequency signal generator 200 selects a pulsatile high-frequency signal according to the patient's condition, converts the selected pulsatile high-frequency signal into a therapeutic pulsatile high-frequency signal, converts it into a wireless form, .

The passive implantable catheter 300 is inserted into a patient's body and receives a therapeutic beating high-frequency signal through the antenna, thereby generating electrical stimulation at a corresponding site. In other words, the basic implantation site is implanted in the cervical vertebrae of pain patients.

However, depending on the patient's condition, two or more passive implantable catheters 300 may be implanted to determine the spinal cord section to be stimulated, and the implanted catheter may be controlled by the synchronous mode.

The therapeutic beating high frequency signal generating apparatus 200 serves to select a frequency necessary for treating pain or nerve abnormality and provides a therapeutic beating high frequency signal generation request based on the frequency information selected by the physical force externally applied And a pulsating high frequency signal generating unit 220 for generating a pulsating high frequency signal when the therapeutic pulsed high frequency signal generating signal is inputted from the input unit 210, A pulsating high frequency generating unit 230 for generating and outputting a predetermined pulsatile high frequency signal in response to the control of the controller 220 and a control unit 220 for receiving a therapeutic initial signal from the control unit 220, Frequency high-frequency signal from the high-frequency generating unit 230 to convert the mixed high-frequency signal into a therapeutic electric signal, A pulsatile high-frequency power amplifier 250 for receiving and amplifying a therapeutic electric signal from the pulsatile high-frequency gateway 240, and a pulse-type high-frequency power amplifier 250 for amplifying the amplified therapeutic electric signal in a radio- A radio power control unit 260 for converting the radio frequency signal into a pulsatile high frequency signal and transmitting it through an antenna 270, a storage unit 280 for storing a plurality of patient state information and a plurality of patient state information linked with duration and treatment time information, .

The input unit 210 may include a touch screen type or a plurality of knob switches. When selecting a frequency required for treating a pain, a duration and a treatment time of the frequency may be selected.

That is, when the input unit 210 forms a touch screen, the input unit 210 simultaneously has a function of an output unit, provides all menu items for generating a pulsating high-frequency signal for controlling pain and nerve disorders, So that the user can select and input the condition. On the other hand, when the input unit 210 is composed of a plurality of knob switches, an output unit is separately provided. The knob switch can be selected by selecting a pulse and a high frequency signal based on the selected pulsating high frequency signal, When the knob switch is rotated, the control unit 220 recognizes the knob switch and outputs the current value of the knob switch through the output unit.

The control unit 220 provides a plurality of patient condition information through the input unit 210 and selects one of the patient condition information from the patient condition information to select the therapeutic frequency, duration, Can be provided. That is, in this case, the input unit 210 is provided in the form of a touch screen.

The control unit 220 reads the information stored in the storage unit 280 and provides the information through the input unit 210. [

The wireless power control unit 260 performs high frequency matching with the antenna 310 connected to the passive implantable catheter 300 and monitors the output state of the therapeutic pulsatile high frequency signal transmitted through the antenna 270.

The operation of the ex vivo pulsatile high frequency stimulation device for a passive catheter constructed as described above will be described below.

First, the doctor or therapist places the patient on the treatment bed in a lying position and then, through the input unit 210 of the therapeutic beating high frequency signal generating device 200, the duration of the high frequency signal and the high frequency signal suitable for the patient's pain, ), And the treatment time (time).

The passive implantable catheter 300 equipped with the antenna 310 is implanted between the vertebrae and the vertebrae through the procedure.

When the duration and the treatment time of the pulsatile high frequency signal and the pulsatile high frequency signal are set through the input unit 210 as described above, the control unit 220 recognizes the pulse duration and the treatment time and outputs the pulsating high frequency And generates an initial signal for treatment based on the pulsatile high frequency signal, the duration of the pulsatile high frequency signal, and the treatment time information set through the input unit 210, and outputs the signal to the pulsatile high frequency gateway 240. At this time, the pulsatile high frequency generator 230 also generates a pulsatile high frequency signal and outputs it to the pulsatile high frequency gateway 240.

Then, the pulsatile high-frequency gateway 240 mixes the therapeutic initial signal and the pulsatile high-frequency signal of the controller 220, converts the pulsed high-frequency signal into a therapeutic electrical signal, and outputs the electrical signal to the pulsatile high-frequency power amplifier 250.

The pulsatile high frequency power amplifying unit 250 amplifies the inputted therapeutic electric signal and outputs the amplified therapeutic electric signal to the wireless power controller 260. The wireless power controller 260 converts the amplified therapeutic electric signal into a wireless signal, The therapeutic electrical signal in the form of a radio signal transmitted through the antenna 270 is received through the antenna 310 implanted in the patient's body and applied to the electrode 320, ) Allows electrical stimulation through the pulsatile high frequency signal inside the patient's body. Such electrical stimulation alleviates the patient's pain or nervous anomalies, and it is possible to treat pain and nervous anomalies when it is periodically provided for a certain period of time.

FIG. 2 is a graph showing the results of a comparison between a condition of "600 sec 55 V, 5 Hz / 5 ms, 300 Ω, 200 mA done" (FIG. 2 ), A pulsatile high-frequency signal was applied to electrodes implanted in the sacrum between the vertebrae and the vertebrae of the patient. This treatment was continued for 3 to 4 days, and the voiding pain was improved by 40%. Relatively comfortable urine (See FIG. 2 (b)) under the conditions of "Pulsed RF 600 sec 55 V, 5 Hz / 5 ms, 300 Ω, and 200 mA done" through an in vitro pulsatile high frequency stimulation device Two electrodes were used to apply electric stimulation to the site to treat the pain, and the pain improved.

FIG. 3 is a photograph of a patient complaining of fever in an anal perineal pain and the like and showing a photograph (see FIG. 3 (a)) and a photograph (see FIG. 3 (b) The patient is appealing. In this case, the passive catheter of the present invention was transplanted to the patient, and the pulsed RF 600Hz 55V, 5 Hz / 5 ms, 360 Ω, 150 mA done "was delivered to the electrode implanted between the vertebrae and the vertebral body, and the stimulus was applied to the affected area for 30 minutes using the pulsatile high-frequency signal. After that, the feeling of heat was improved by 30% or more 100%. The pain on the caudal bone was improved by 40 ~ 50% after 5 days of pain after treatment with pulsatile high frequency signal. After treatment with this pulsatile high frequency signal for one month, the pain of the caudal bone was improved by 70% compared to the first, and there was almost no sense of opening on the back, and it remained only in the left arm side.

FIG. 4 shows the results of the study on the results of the analysis of the results of the present study. The results are shown in FIG. 4, which shows that both of the arms are missed, the pain is felt by the night, the pain is difficult to fall asleep and the left arm and the left hand are depressed, Passive catheter according to the present invention was transplanted to a patient (amyotrophic lateral sclerosis), and a pulsatile high frequency signal having a condition of "Pulsed RF 600sec 55V, 5Hz / 5ms, 182ohm, 304mA done" After electrical stimulation, the pain was relieved and the arm was relaxed from 70% to 85% in the left arm, 0.5 kg of dumbbell exercise was possible, , Left-handed paper can be picked up, and the feeling of dullness was reduced by walking, and it was improved to walk 4 ~ 5km at a time.

FIGS. 5 to 7 show a patient who is admitted for continuous rehabilitation treatment due to neuropathic pain and who is suffering from painful hands and feet, Frequency signal having a primary pulsed RF mode of 600 sec, 55 V, 5 Hz / 20 ms, 42 캜 and 320 Ω (see FIG. 5 (a)) via the in vitro pulsatile high- As shown in FIG. 6 (a), after treatment with electrical stimulation, the limbs and limbs fell on the day following the procedure. Thereafter, the limbs were slightly lower than before the procedure, As shown in Fig. 7, the pain was alleviated so as to change the inclination of the bed and the backrest angle of the wheelchair, and the secondary "Pulsed RF mode: 600 sec, 55 V, 5 Hz / 5 ms, (Refer to FIG. 5 (b)) is applied to a subject to be treated with electric stimulation to the corresponding region, and then, as shown in FIG. 6 (b) It was found that it fell further.

Fig. 8 is a graph showing the results of a transplantation of a passive catheter according to the present invention to a patient who complains of pain on the back of a girdle and a sole of the foot, and an electric stimulation is applied to the corresponding region using a pulsatile high frequency signal The pain was reduced by 50% in both patients after these treatments, and the feeling of treading of two feet of gravel was reduced but the size of the pain was smaller than before.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or essential characteristics thereof. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the scope of equivalents should be construed as falling within the scope of the present invention.

200: Therapeutic pulsatile high-frequency signal generator
210: input unit 220:
230: Pulsatile high frequency generator
240: Pulse High Frequency Gateway
250: pulsed high frequency power amplifying part
260: wireless power control unit 270: antenna
280:
300: passive biotransplantation catheter
310: antenna 320: electrode

Claims (8)

A pulsatile high frequency signal generator for converting the selected pulsatile high frequency signal information into a therapeutic pulsatile high frequency signal and then converting the pulsed high frequency signal information into a wireless form and transmitting the pulsed high frequency signal through an antenna; And
A passive implantable catheter for receiving a therapeutic beating high frequency signal through an antenna implanted in a body and generating electrical stimulation at a corresponding site; Lt; / RTI >
In order to stimulate the desired spinal nerve section by inserting two passive implantable catheters into the body, two therapeutic beating high-frequency signal generators are provided in a synchronous mode in order to synchronize stimulation of two passive implantable catheters In vitro pulsatile high frequency stimulation device for passive catheter.
The method according to claim 1,
Wherein the therapeutic pulsatile high-frequency signal generator comprises:
An input unit for generating a therapeutic beating high frequency signal generation request signal based on frequency information selected by a physical force applied from the outside,
A control unit for generating and outputting a therapeutic initial signal when the therapeutic beating high frequency signal generation request signal is inputted from the input unit and controlling the beating high frequency signal generating unit to generate the pulsatile high frequency signal,
A pulsatile high-frequency signal generator for generating and outputting a predetermined pulsatile high-frequency signal in response to the control of the controller,
A pulsatile high-frequency gateway for receiving a therapeutic initial signal from the control unit, receiving pulsating high-frequency signal information from the pulsatile high-frequency signal generating unit, mixing the pulsed high-frequency signal information into a therapeutic electric signal, and outputting a therapeutic electric signal,
A pulsatile high frequency power amplifying part for receiving and amplifying a therapeutic electric signal from the pulsatile high frequency gateway,
And a radio power control unit for converting the amplified therapeutic electrical signal into a radioactive therapeutic beating high frequency signal and transmitting the same via an antenna.
delete 3. The method of claim 2,
Wherein the input unit serves to select a duration and a treatment time of a frequency when selecting a frequency required for pain therapy or neurological adjustment treatment.
3. The method of claim 2,
Wherein the control unit provides a plurality of patient condition information through the input unit and provides an interface screen for selecting a treatment frequency, a duration, and a treatment time when one of the patient condition information is selected In-vitro pulsatile high-frequency stimulation device for a passive catheter.
3. The method of claim 2,
Wherein the therapeutic pulsatile high-frequency signal generator comprises:
Further comprising a storage unit for storing a plurality of patient condition information and a plurality of patient condition information linked with duration and treatment time information,
Wherein the control unit reads the information stored in the storage unit and provides the read information through the input unit.
3. The method of claim 2,
Wherein the input unit is provided in the form of a touch screen.
3. The method of claim 2,
Wherein the radio power control unit performs high frequency matching with an antenna connected to the electrode and monitors an output state of the therapeutic pulsatile high frequency signal transmitted through the antenna.

Images