KR101649074B1 - Method for sensing intercellular potential difference and breastcancer diagnosis system thereof - Google Patents

Method for sensing intercellular potential difference and breastcancer diagnosis system thereof Download PDF

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Publication number
KR101649074B1
KR101649074B1 KR1020150049982A KR20150049982A KR101649074B1 KR 101649074 B1 KR101649074 B1 KR 101649074B1 KR 1020150049982 A KR1020150049982 A KR 1020150049982A KR 20150049982 A KR20150049982 A KR 20150049982A KR 101649074 B1 KR101649074 B1 KR 101649074B1
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South Korea
Prior art keywords
sensor
branch line
sensor electrode
examinee
pad
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KR1020150049982A
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Korean (ko)
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이경호
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이경호
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0041—Detection of breast cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0024—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system for multiple sensor units attached to the patient, e.g. using a body or personal area network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6823—Trunk, e.g., chest, back, abdomen, hip

Abstract

The present invention relates to a sensor pad which measures biometric potential to diagnose whether a body lesion tissue occurs. The sensor pad comprises: a sensor electrode provided to be palpated on a skin surface of an examinee, is formed of a circular or ring-shaped conductive metal plate, and is formed with a diameter of 1-8 mm; an adhesion base which comes in close contact with a rear side of the sensor electrode, is formed to have a diameter greater than that of the sensor electrode such that the edge thereof is adhered to the skin surface of the examinee, and is made of a water-soluble gel material; a body unit coupled to a rear side of an adhesion base and provided to fixate the sensor electrode and the adhesion base; and a connector unit provided to extend from one side of the body unit, and provided to electrically be connected to the sensor electrode. According to the sensor pad to measure biometric potential in accordance with the present invention, a size of the sensor electrode is minimized, is possible to diagnose early a lesion, is possible to diagnose early a lesion with a size which cannot be diagnosed by an existing equipment such as breast cancer, and is possible to increase a rate of cure. Sensor pads with various sizes are provided in accordance with the examinees body size, and the sensor electrode is disposed at a predetermined rate; thereby accurately diagnosing a main disease-occurring portion.

Description

TECHNICAL FIELD The present invention relates to a method for measuring a potential difference between cells and a breast cancer diagnosis system using the same,

The present invention relates to a breast cancer discrimination system, and more particularly, to a method for measuring an intercellular potential difference capable of discriminating the onset of breast cancer by measuring a potential difference between normal tissue and cancer tissue, and a breast cancer discrimination system using the same.

Breast cancer is usually difficult to distinguish from other forms such as scarring or enlargement of the mammary gland at the early stage of development. Therefore, only when the size of the tissue is increased to 10 mm or more, it can be confirmed using conventional diagnostic equipment such as X-ray, ultrasound and MRI Do. Especially in Asian women, there are many cases of dense breast with less fat and more developed wings than Western women. In this case, it is difficult to confirm breast cancer by existing diagnostic equipment.

On the other hand, the normal cells of the human body undergo the process of disruption through the dormant and differentiator. At this time, the cell in the cleavage process opens the cell membrane and ion exchange with the intercellular tissue becomes active, thereby reducing the potential difference. Normally, normal cells maintain a potential of about -70 mV at rest and -15 mV at the differentiation stage. On the other hand, cancer cells maintain cell potential at -15mV at all times without any resting potential because cell differentiation occurs constantly without rest period. By detecting such a potential difference, tumor tissues having a size of 10 mm or less can be distinguished.

Korean Patent No. 10-0794721 discloses a biosensor comprising: a sensor driver having at least one or a plurality of biosensors each of which has a capacitance change by receiving a bioelectromagnetic field in an organism including a human body; An analog circuit for processing the bioelectric potential signal measured through the sensor driving unit into an analog signal; A digital conversion circuit unit for converting an analog signal output from the analog circuit unit into a digital signal and processing the digital signal; A communication circuit for communicating with a PC; and a communication module for wireless communication with the PC. The electromagnetic field radiated from the subject and the variation thereof And provides a non-invasive real-time disease diagnosis system by analysis.

The cited technique measures a change in electrostatic capacitance of a biosensor according to a change in an electromagnetic field of a human body input to the biosensor, converts the deviation of the biosensor from a reference value into a deviation of a frequency and measures the abnormality, (permittivity or capacitance).

However, the biosensor provided by the above cited technology is obtained by processing from a natural substance, which is difficult to manufacture and process, and thus causes a cost increase. In addition, since it has its own unique frequency, it has to be subjected to a separate rectification process, thereby increasing the complexity of the examination system.

In order to solve the above-mentioned problems, the present invention provides a sanitary and safe bio-potential measuring sensor pad which can be easily manufactured, safely seated on the skin of a subject, Lt; / RTI >

The sensor pad is charged by micro current generated in the human body and generates a unique voltage. By acquiring and analyzing it by the diagnostic device, it is possible to diagnose the occurrence of the disease by capturing the abnormal current caused by the abnormal tissue have.

Other objects of the present invention will become readily apparent from the following description of the embodiments.

In order to achieve the above object, according to one aspect of the present invention, there is provided an ultrasonic diagnostic apparatus comprising: a sensor electrode, which is formed to have a diameter of 1 to 8 mm and is formed of a circular or annular conductive metal plate, ; An adhesive pad which is adhered to the back surface of the sensor electrode and has a diameter larger than that of the sensor electrode so that the edge is adhered to the skin surface of the subject and is made of a water soluble gel material; A body coupled to a back surface of the adhesive band to fix the sensor electrode and the adhesive band; And a connector portion extending from one side of the body portion, the connector portion being electrically connected to the sensor electrode.

The body portion is composed of a pair of film-like circuit boards attached to the left and right breast surfaces of the examinee, and is provided with a plurality of sensor electrodes spaced apart from each other by eight branch lines branched from the central portion, The nipple being protruded and seated; A first branch line branched toward the abdomen side of the examinee about the through hole; A second branch line branched toward the subject's chest bone centered on the aperture; A third branch line branched toward the shoulder side of the examinee about the through hole; And a fourth branch line branched toward the side of the examinee about the through hole.

Wherein the first branch line, the second branch line, the third branch line, and the fourth branch line are formed to have a length according to the following ratio with respect to the length of the first branch line: Pad: 2nd branch line: 1 占 (0.05 to 0.1); Third branch line: 1.6 ± (0.05-0.1); Line 4: 2.25 ± (0.05-0.1).

Wherein the body part further comprises an independent measurement type sensor pad formed of a circular or rectangular film circuit board attached to one side of the subject's breast and having at least one of the sensor electrodes spaced apart at a predetermined interval, A pad is provided.

And a breast cancer examination device electrically connected to the connector unit and adapted to measure the voltage applied to the sensor electrode, and record and analyze the voltage to check whether the test subject has an onset.

According to the sensor pad for measuring bioelectrical potential according to the present invention, the sensor pad can be easily attached to the skin surface of the subject, and the sensor electrode can be stably touched to the skin by the adhesive pad made of a gel material, .

Since the sensor electrode is made of silver chloride (AgCl), which is highly economical, it can be used for disposable use and can be used hygienically.

In addition, since the size of the sensor electrode can be minimized, it is possible to perform early diagnosis of the lesion of early onset. Thus, it is possible to early diagnose a lesion which is not diagnosed by conventional equipment such as breast cancer,

Sensor pads of various sizes are provided according to the body size of the subject, and sensor electrodes are arranged at a certain ratio, so that a precise examination for a major onset area can be made.

1 is an elevation view showing an embodiment of a sensor pad for measuring bioelectrical potential according to the present invention.
2 is a cross-sectional view showing one embodiment of a sensor pad for measuring bioelectrical potential according to the present invention.
3 is a configuration diagram showing a method of using the sensor pad for measuring bioelectrical potential according to the present invention.
4 is an elevation view showing another embodiment of the sensor pad for measuring bioelectrical potential according to the present invention.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but is to be understood to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention, And the scope of the present invention is not limited to the following examples.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings, wherein like or corresponding elements are denoted by the same reference numerals, and redundant explanations thereof will be omitted.

FIG. 1 is an elevation view showing an embodiment of a sensor pad for measuring bioelectrical potential according to the present invention, and FIG. 2 is a cross-sectional view illustrating an embodiment of a sensor pad for measuring bioelectrical potential according to the present invention.

1 and 2, the sensor pad 100 of the present invention may include a sensor electrode 111, a bonding pad 113, and a body portion 114.

The sensor pad 100 according to the present invention is for detecting microcurrent generated in subcutaneous tissues attached to both breast or one side of a female subject and is provided on the sensor pad 100 by micro current generated in the tissue. And the sensor electrode 111 is charged.

As described above in the Background of the Invention, as described above, the metabolites are taken out from the cells in the body tissues including the human body by the exchange of calcium and potassium ion to the cell membrane. Thus, a constant level of dislocation is formed in the inner and outer portions of the cell membrane. Generally, a potential of -70 mV is maintained at the resting stage, and the cell membrane is opened to the cell divider, and the dislocation is decreased to about -10 mV level.

In normal cells, the repetitive and cleaved repeats are repeated, and the repetitive and disruptive potentials appear repeatedly. On the other hand, in cancer cells, the action potential is lower than normal cells have.

Therefore, the conductor can be electrostatically charged by the electric current generated in the cells in the tissue by adhering the conductor to the surface of the skin. By using the difference in potential between normal cells and cancer cells, can do.

Accordingly, the sensor electrode 111 according to the present invention can be made of a conductor having low self impedance so as to be charged by the micro current generated in the subcutaneous tissue. For example, a sensor electrode 111 made of gold (Au) may be used as an ideal conductor. However, it is preferable that the sensor pad 100 according to the present invention is a member which comes into direct contact with the skin of the subject and is used for one time for hygienic use. In this case, the gold sensor electrode 111 may be inferior in economy . Therefore, when actual commercialization is considered, it is preferable to apply the sensor electrode 111 made of silver chloride (AgCl).

Referring to FIG. 2, the sensor electrode 111 is formed in a disk shape, and is adhered to the rear surface of the body 114 by a bonding pad 113 of a water-soluble gel material. Here, the diameter d of the sensor electrode 111 is set to 1 to 8 mm. The diameter d of the sensor electrode 111 is a major factor for detecting the lesion tissue occurring in the subcutaneous tissue.

In general, the diagnosis of breast cancer is made by ultrasound equipment, X-rays, and MRI. The minimum size of breast cancer tissue that can be diagnosed and confirmed by these devices is known to be at least 10 mm. This is because it is difficult to distinguish the lesion tissue from the mammary gland and the mammary gland in the early stage of cancer. Especially in oriental women, the mammary gland tissue is relatively developed and the initial diagnosis is difficult due to the conventional diagnostic equipment.

The sensor pad according to the present invention allows the abnormal current generated in the early cancer tissue within 5 mm to 10 mm to be scanned separately from the surrounding normal tissue by making the size of the sensor electrode 111 8 mm or less, This is possible.

Accordingly, it is preferable that the size of the sensor electrode 111 is set to 5 mm or less. However, the sensor electrode 111 can be made up to 8 mm in consideration of practical operation and efficiency of the device.

The adhesive pad 113 is provided as a disk-like or annular member made of a water-soluble gel material having a diameter larger than the diameter of the sensor electrode 111 so that the adhesive pad 113 is disposed around the sensor electrode 111 to closely contact the sensor electrode 111 And protects the sensor electrode 111 from static electricity generated on the surface of the skin. For example, the adhesive pad 113 may be made of a sodium chloride (NaCl) polymer or a colloidal gel material.

The body portion 114 is formed of a film-like circuit board and includes a conductive line for electrically connecting the sensor electrode 111 to an external device. The body portion 114 has a function of attaching and supporting the sensor electrode 111 and the adhesive pad 113 .

2, the sensor electrode 111 and the adhesive pad 113 are attached and fixed to one surface of the body 114, and the conductive line 112 electrically connected to the sensor electrode 111 is embedded on the inner surface thereof . A connector portion 115 is formed on one side of the body portion 114 to form a conductive line 112 so that the sensor electrode 111 can be electrically connected to an external device.

The sensor pad 100 according to an aspect of the present invention may be provided in a shape such that the sensor electrode 111 is distributed by dividing the subject's breast into eight regions. A first branch line R branched to the abdomen side of the examinee about the through hole 116 formed at the center of the body part 114, a second branch line B branched toward the chest bone side, A fourth branch line D branched to the third branch line C and the side of the side is formed and the sensor electrodes 111 connected to the conductive line 112 on the respective branch lines are formed to be distributed in a line have. An additional quadrangular branch line extends between the branch lines. The length of the quadrangular branch line is adjusted according to the width of each quadrant divided by the branch lines.

Here, the lengths of the reference first to fourth branch lines are adjusted in accordance with the respective ratios based on the length of the first branch line (R).

Second branch line (B): 1 占 (0.05-0.1);

Third branch line (C): 1.6 占 (0.05-0.1);

Line 4 (D): 2.25 ± (0.05-0.1).

In other words, in the case of the second branch line B, the length of the first branch line R may be about 1.05-1.1 with the length of the first branch line R being 1.

By arranging the lengths of the first branch line to the fourth branch line in accordance with the above-mentioned ratio, the sensor arrangement of each side of the breast according to the general shape of the breast around the nipple of the subject can be made uniform. In general, the female breast has a wide face toward the arm side, a narrow face toward the breast side, and a high incidence of cancer tissue along the lymph node, which is distributed under the armpit, under the nipple. Accordingly, the sensor pad provided by the present invention can be precisely measured by increasing the number of sensors in the above-mentioned area, and the sensor pad 100 can be seated with the nipple of the subject as the reference point, .

The sizes of the breasts may vary according to individual characteristics of the subject, and accordingly, it is preferable that the sizes of the sensor pads 100 are also classified into a plurality of sizes according to predetermined sizes.

The sensor pad 100 according to the present invention can standardize the size of the sensor pad 100 according to the ratio of the branch lines and the general breast size as described below.

Branch line
\
Breast size
R
B
C
D
B + D AA 28 28 46 63 91 A 32 32 52 72 104 B 36 36 59 81 117 C 40 40 65 90 130 D 44 44 72 99 143 DD 46 46 75 104 150 E 50 50 81 113 163 F 54 54 88 122 176 FF 58 58 94 131 189 G 62 62 101 140 202

According to the standard of Table 1, the interval of the sensor electrodes 111 located on the quadrangular branch line between the first branch line and the fourth branch line and each branch line is also adjusted to be widened or narrowed at a constant ratio .

According to an aspect of the present invention, the sensor pad 100 may be formed of a pair of symmetrical pads to be attached to both sides of the subject's breast. However, the shape of the sensor pad according to the present invention is not limited thereto, and may include a sensor pad having a shape for precisely scanning a specific part of the breast.

Referring to FIG. 4, the sensor pad 200 for precise scanning includes a body 214 having a circular or rectangular shape, and a plurality of sensor electrodes 111 and an adhesive pad 113 are attached . At this time, the sensor electrode 111 can be made to have a relatively small diameter for more precise scanning. For example, the sensor electrode 111 constituting the sensor pad 100 according to one aspect of the present invention may be provided to have a diameter of 8 mm, and the sensor electrode 211 constituting the sensor pad 200 according to another embodiment, May be provided to have a diameter of 5 mm or less.

Referring to FIG. 3, the sensor pad 100 for measuring bioelectrical potential according to the above-described configuration is configured to measure the voltage applied to the sensor electrode 111, record and analyze the voltage, (300).

The breast cancer examination apparatus 300 includes a potential measurement unit electrically connected to the connector unit 115 provided at one side of the sensor pad 100 to detect the voltage of the sensor electrode 111, And an operation unit for analyzing the voltage data of the electrode 111 to determine whether a lesion has occurred.

The potential measuring unit removes the current noise generated in the main body of the test apparatus 300 and amplifies the fine current applied to the sensor electrode 111 and converts the amplified fine current into a digital signal. The arithmetic unit may analyze the digital signal converted from the potential measurement unit and diagnose whether or not the region to be inspected on which the sensor electrode 111 is located has occurred.

At this time, the sensor electrodes 111 of the left and right sensor pads 100 are distributed in the symmetrical positions, so that the voltage values measured by the sensor electrodes 111 on both sides are compared and if the voltage difference exceeds a certain level, can do.

The operation of the sensor pad for measuring bioelectrical potential according to the present invention will now be described.

The examinee is laid down on the test bed so that the upper body of the subject is inclined at about 15 degrees so that the sensor pad 100 can be seated on the subject's breast. The sensor pad 100 is placed in such a manner that the nipple of the examinee is exposed to the central through hole 116 of the sensor pad 100 when the subject's breast is flattened So as to stably adhere to the skin surface of the subject.

At this time, the inspector can select and apply a suitable sensor pad 100 among the plurality of sensor pads 100 according to the body size of the subject.

When the attachment of the sensor pad 100 is completed, the sensor pad 100 is connected to the inspection apparatus 300 using the connector unit 115 and the inspection apparatus 300 is operated. The inspection apparatus 300 can derive the inspection result by measuring and analyzing the voltage value from the sensor electrode 111 charged by the biological current of the subject.

If the voltage value of the specific region exceeds the normal value, the inspector removes the existing sensor pad 100, attaches the localized sensor pad 200 according to the present invention to a specific site, ) And can be re-inspected.

When the inspection is completed, the attached sensor pad 100 is removed. Since the sensor pad 100 is used for disposable use, the removed sensor pad 100 can be discarded.

Although the present invention has been described with reference to the accompanying drawings, it is to be understood that various changes and modifications may be made without departing from the spirit of the invention. Therefore, the scope of the present invention should not be limited to the described embodiments, but should be determined by the equivalents of the claims, as well as the following claims.

100: Sensor pad
111: sensor electrode 112: conductive wire
113: Adhesive band 114: Body part
115: Connector part R: 1st branch line
B: 2nd branch line C: 3rd branch line
D: 4th branch line 200: Sensor pad for local diagnosis
300: Breast cancer diagnostic device

Claims (5)

A sensor electrode which is provided on the skin surface of the examinee so as to be palpable and is formed of a circular or annular conductive metal plate and is formed to have a diameter of 1 to 8 mm;
An adhesive pad which is adhered to the back surface of the sensor electrode and has a diameter larger than that of the sensor electrode so that the edge is adhered to the skin surface of the subject and is made of a water soluble gel material;
A body coupled to a back surface of the adhesive band to fix the sensor electrode and the adhesive band;
A connector portion extending from one side of the body portion and adapted to electrically connect the sensor electrodes;
And a breast cancer examination device electrically connected to the connector unit and adapted to measure the voltage applied to the sensor electrode and record and analyze the voltage to detect the onset of the examination site,
The body portion
A plurality of sensor electrodes arranged at predetermined intervals on eight branch lines branched from the central portion, the plurality of sensor electrodes being spaced apart from each other by a predetermined distance,
A through hole formed in the center so that the nipple of the examinee protrudes and seats;
A first branch line branched toward the abdomen side of the examinee about the through hole;
A second branch line branched toward the subject's chest bone centered on the aperture;
A third branch line branched toward the shoulder side of the examinee about the through hole; And
And a fourth branch line branched to the side of the examinee about the through hole,
The first branch line, the second branch line, the third branch line, and the fourth branch line,
Wherein the sensor pad is formed to have a length according to the following ratio with respect to the length of the first branch line:
2nd branch line: 1 ± (0.05-0.1);
Third branch line: 1.6 ± (0.05-0.1);
Line 4: 2.25 ± (0.05-0.1). delete delete delete delete
KR1020150049982A 2015-04-09 2015-04-09 Method for sensing intercellular potential difference and breastcancer diagnosis system thereof KR101649074B1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101739656B1 (en) 2015-11-23 2017-05-24 이경호 Handy-type Breast Cancer Diagnosis Device
KR101789884B1 (en) 2015-11-28 2017-10-25 이경호 Breast Cancer Diagnosis Method Using Handy-type Breast Cancer Diagnosis Device
KR20210035961A (en) * 2019-09-24 2021-04-02 서울대학교병원 Tissue Expander For Breast Reconstruction Being Capable of Real-Time Monitoring and Treatment of Capsular Contracture Based on Current or Voltage Sensor and Patients Information System Associated Therewith
KR20230136490A (en) 2022-03-18 2023-09-26 서울대학교산학협력단 Branched nanosheet, method for forming branched nanosheet, and nanocomposite comprising branched nanosheet

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH10508227A (en) * 1994-10-17 1998-08-18 バイオフィールド コーポレーション DC biopotential measurement electrode and conductive medium used for the electrode
JP2011505966A (en) * 2007-12-11 2011-03-03 エピ‐サイ，リミテッド・ライアビリティ・カンパニー Electrical bioimpedance analysis as a biomarker of breast density and / or breast cancer risk
KR20140088390A (en) * 2013-01-02 2014-07-10 (주) 태웅메디칼 Patch type electrode for body signal measure
KR101490811B1 (en) * 2013-12-04 2015-02-06 주식회사 케이헬쓰웨어 Electrical Impedance Tomography Apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508227A (en) * 1994-10-17 1998-08-18 バイオフィールド コーポレーション DC biopotential measurement electrode and conductive medium used for the electrode
JP2011505966A (en) * 2007-12-11 2011-03-03 エピ‐サイ，リミテッド・ライアビリティ・カンパニー Electrical bioimpedance analysis as a biomarker of breast density and / or breast cancer risk
KR20140088390A (en) * 2013-01-02 2014-07-10 (주) 태웅메디칼 Patch type electrode for body signal measure
KR101490811B1 (en) * 2013-12-04 2015-02-06 주식회사 케이헬쓰웨어 Electrical Impedance Tomography Apparatus

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101739656B1 (en) 2015-11-23 2017-05-24 이경호 Handy-type Breast Cancer Diagnosis Device
KR101789884B1 (en) 2015-11-28 2017-10-25 이경호 Breast Cancer Diagnosis Method Using Handy-type Breast Cancer Diagnosis Device
KR20210035961A (en) * 2019-09-24 2021-04-02 서울대학교병원 Tissue Expander For Breast Reconstruction Being Capable of Real-Time Monitoring and Treatment of Capsular Contracture Based on Current or Voltage Sensor and Patients Information System Associated Therewith
KR102315044B1 (en) * 2019-09-24 2021-10-22 서울대학교병원 Tissue Expander For Breast Reconstruction Being Capable of Real-Time Monitoring and Treatment of Capsular Contracture Based on Current or Voltage Sensor and Patients Information System Associated Therewith
KR20230136490A (en) 2022-03-18 2023-09-26 서울대학교산학협력단 Branched nanosheet, method for forming branched nanosheet, and nanocomposite comprising branched nanosheet
KR102620022B1 (en) * 2022-03-18 2024-01-02 서울대학교산학협력단 Branched nanosheet, method for forming branched nanosheet, and nanocomposite comprising branched nanosheet

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