CN117481660A - Implantable multipurpose electroencephalogram signal acquisition system - Google Patents
Implantable multipurpose electroencephalogram signal acquisition system Download PDFInfo
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- CN117481660A CN117481660A CN202311649177.XA CN202311649177A CN117481660A CN 117481660 A CN117481660 A CN 117481660A CN 202311649177 A CN202311649177 A CN 202311649177A CN 117481660 A CN117481660 A CN 117481660A
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- electrode
- electroencephalogram
- voltage
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 claims abstract description 12
- 238000012545 processing Methods 0.000 claims abstract description 6
- 230000000638 stimulation Effects 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 6
- 239000004642 Polyimide Substances 0.000 claims description 3
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 3
- 210000005013 brain tissue Anatomy 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 3
- 229920001721 polyimide Polymers 0.000 claims description 3
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 210000003710 cerebral cortex Anatomy 0.000 abstract description 6
- 230000002490 cerebral effect Effects 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 3
- 210000004556 brain Anatomy 0.000 description 23
- 238000012544 monitoring process Methods 0.000 description 13
- 230000005284 excitation Effects 0.000 description 6
- 208000014644 Brain disease Diseases 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920005570 flexible polymer Polymers 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010048962 Brain oedema Diseases 0.000 description 1
- 208000018152 Cerebral disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
Abstract
The invention provides an implantable multipurpose electroencephalogram signal acquisition system which is characterized by comprising an electrode unit, wherein the electrode unit is sequentially connected with a filtering unit, a signal amplifying unit, a voltage-current conversion unit, an analog-digital conversion unit, a signal recording unit, a switch unit, a signal generator unit and a processing control unit; the electroencephalogram signals picked up by the electrode units sequentially pass through a filtering circuit and a signal amplifying circuit to carry out filtering and amplifying treatment on the electroencephalogram signals; the processed voltage signal is converted into a digital signal through an analog-to-digital conversion unit. The flexible bioelectrode sheet is prepared based on the bio-friendly flexible material, so that the conformal attachment of the electrode and the complex curved surface of the human body surface/cerebral cortex surface is realized, the contact impedance between a measuring site and human tissues is effectively reduced, and the voltage and cerebral impedance detection precision is improved.
Description
Technical Field
The invention provides an implantable multipurpose electroencephalogram signal acquisition system, and belongs to the technical field of wearable equipment.
Background
Brain impedance is an important physiological indicator, and abnormal rise of brain impedance is usually accompanied by serious diseases of various brains such as cerebral apoplexy. The study shows that the possibility of good prognosis is increased by about 8% when the time interval from the onset to the treatment of cerebral apoplexy and cerebral edema is reduced by 60 minutes, so the method has important significance for timely monitoring and early warning of related cerebral diseases. At present, the main monitoring means CT of brain diseases can only identify the brain when the brain is easy to generate obvious occupying deformation degree, and the treatment time is greatly delayed. Therefore, the invention provides an implantable brain impedance and brain impedance monitoring system which can realize brain impedance and brain impedance monitoring at the same time, and upload monitoring data to an in-vitro upper computer to realize the real-time monitoring and early warning of brain diseases.
The traditional brain impedance measuring equipment generally adopts electrodes laid on the surface of the scalp of a person, and realizes the real-time measurement of brain impedance by means of percutaneous electrical stimulation and brain electrical signal monitoring. In this way, the sum of the brain impedance and the electrode-body surface contact impedance is actually measured, and the contact impedance between the conventional extracorporeal electrode and the human skin is usually not negligible, and the magnitude of the contact impedance cannot be accurately calculated, so that a large error exists in the brain impedance value obtained by adopting the conventional method. The invention provides an implantable multipurpose electroencephalogram signal acquisition system, wherein an acquisition device can be directly implanted into a cranial cavity for signal acquisition, and can realize conformal attachment with a cerebral cortex, so that contact impedance is greatly reduced.
Disclosure of Invention
The invention provides an implantable multipurpose electroencephalogram signal acquisition system which is characterized by comprising an electrode unit, wherein the electrode unit is sequentially connected with a filtering unit, a signal amplifying unit, a voltage-current conversion unit, an analog-to-digital conversion unit, a signal recording unit, a switch unit, a signal generator unit and a processing control unit; the electroencephalogram signals picked up by the electrode units sequentially pass through a filtering circuit and a signal amplifying circuit to carry out filtering and amplifying treatment on the electroencephalogram signals; the processed voltage signal is converted into a digital signal through an analog-to-digital conversion unit.
Comprising at least 2 electrode units.
The electrode unit is a flexible electrode slice and comprises a flexible substrate, a connecting circuit, a packaging layer and at least 3 Ag/AgCl electrode points, wherein at least 1 electric stimulation electrode point and at least 2 detection electrode points; the electric stimulation electrode point can release an alternating current signal with adjustable frequency to brain tissues under the control of the upper computer, and the detection electrode point obtains a voltage signal at the electrode unit and is transmitted to the upper computer for analysis and recording through the communication port.
The electrode units are arranged on the flexible polyimide substrate in an array mode, and the electrode units are provided with signal output ends and signal input ends, and the signal input ends are connected with the signal input ends of the signal amplifying unit and the filtering unit.
The invention provides an electroencephalogram/brain impedance integrated real-time monitoring system based on a flexible electrode array, which has two functions of real-time electroencephalogram monitoring and real-time brain impedance monitoring and can give related disease early warning signals according to brain voltage/brain impedance values. The flexible bioelectrode sheet is prepared based on the bio-friendly flexible material, so that the conformal attachment of the electrode and the complex curved surface of the human body surface/cerebral cortex surface is realized, the contact impedance between a measurement site and human tissues is effectively reduced, and the voltage and cerebral impedance detection precision is improved. In addition, the adopted flexible polymer material has good air permeability, and the perspiration effect of a human body is avoided when the flexible polymer material is contacted with the surface of the human body.
Drawings
FIG. 1 is a schematic view of an electrode unit structure of the present invention;
FIG. 2 is a schematic illustration of the use of an electrode unit of the present invention;
fig. 3 is a signal processing flow of the present invention.
Detailed Description
The system provided by the invention has two functions of brain electrical monitoring and brain impedance monitoring. For brain impedance monitoring function, the system adopts a current excitation and voltage detection mode to measure brain impedance, namely, a constant amplitude excitation alternating current is applied to the cerebral cortex through an excitation electrode, and a potential difference signal is picked up through a detection electrode to obtain a brain impedance value. The invention adopts a double-pass four-electrode impedance detection mode,
an implantable multipurpose electroencephalogram signal acquisition system comprises an electrode unit 1, a filtering unit, a signal amplifying unit, a voltage-current conversion unit, an analog-to-digital conversion unit, a signal recording unit, a switch unit, a signal generator unit and a processing control unit.
As shown in fig. 1, the system of the present invention should include at least 2 electrode units 1, where the electrode units 1 are flexible electrode sheets, and have two mounting modes of in vitro wearing and in vivo implantation, and can achieve flexible conformal attachment with the body surface and cerebral cortex of a human body. The electrode unit 1 comprises a flexible substrate, a connecting circuit, an encapsulation layer and at least 3 Ag/AgCl electrode points, wherein 1 electric stimulation electrode point 12 and at least 2 detection electrode points 11 are contained. The electric stimulation electrode point 12 can release an alternating current signal with adjustable frequency to brain tissues under the control of the upper computer, and the detection electrode point 11 can acquire a voltage signal at an electrode site and conduct the voltage signal to the upper computer for analysis and recording through a communication port. The electrode units 1 are arranged on the flexible PI polyimide substrate in an array form, and the electrode units 1 are connected with the signal input and output ends through a connecting circuit prepared by flexible film electrodes. The electrode unit 1 is integrally encapsulated by PLGA polydimethylsiloxane, so that short circuit caused by contact between a circuit and tissue fluid is avoided.
Optionally, for wearing on the body surface, the surface of the electrode array may be covered with a conductive gel material to reduce the contact resistance between the electrode and the body surface of the human body.
The electrode unit 1 has a signal output terminal and a signal input terminal, and the signal input terminal is connected to the signal input terminals of the signal amplifying unit and the filtering unit. The electroencephalogram signal picked up by the electrode unit 1 is generally very weak and is susceptible to interference signals such as contact impedance and signal noise, and therefore, it is necessary to perform filtering and amplifying processing on the electroencephalogram signal by a filtering circuit and a signal amplifying circuit. The processed voltage signal is converted into a digital signal through an analog-to-digital conversion unit.
The signal input end of the electrode unit 1 is connected with the output end of the signal generator through a voltage-current conversion module. The signal generator unit can output an alternating voltage signal with a designated frequency, and the alternating voltage signal is connected with the constant current excitation circuit through the voltage-current conversion unit signal generator excitation electrode and is used for outputting a constant current excitation signal to the cerebral cortex. The alternating current frequency can be regulated within the range of 10 Hz-100 Hz through the controller unit, so that the stimulation and polarization effects of the ultralow frequency current are avoided, and the burn caused by the ultrahigh frequency current to the human body is prevented.
In practical application, as shown in fig. 2. The electrode plates should be placed opposite along the skull/brain center line and attached in such a way that the detection electrodes are located on both sides of the center line. A specific control flow is shown in fig. 3.
Claims (4)
1. An implantable multipurpose electroencephalogram signal acquisition system is characterized by comprising an electrode unit (1), wherein the electrode unit (1) is sequentially connected with a filtering unit, a signal amplifying unit, a voltage-current conversion unit, an analog-digital conversion unit, a signal recording unit, a switch unit, a signal generator unit and a processing control unit; the electroencephalogram signals picked up by the electrode unit (1) are sequentially filtered and amplified by the filtering circuit and the signal amplifying circuit; the processed voltage signal is converted into a digital signal through an analog-to-digital conversion unit.
2. An implantable multi-purpose electroencephalogram signal acquisition system according to claim 1, characterized by comprising at least 2 electrode units (1).
3. An implantable multi-purpose electroencephalogram signal acquisition system according to claim 1, characterized in that the electrode unit (1) is a flexible electrode sheet, the electrode unit (1) comprising a flexible substrate, a connection circuit, a packaging layer and at least 3 Ag/AgCl electrode points, wherein at least 1 electro-stimulation electrode point (12) and at least 2 detection electrode points (11); the electric stimulation electrode point (12) can release an alternating current signal with adjustable frequency to brain tissues under the control of the upper computer, and the detection electrode point (11) acquires a voltage signal at the electrode unit (1) and is conducted to the upper computer for analysis and recording through the communication port.
4. The system according to claim 1, wherein the electrode units (1) are arranged on the flexible polyimide substrate in an array form, the electrode units (1) have signal output ends and signal input ends, and the signal input ends are connected with the signal input ends of the signal amplifying unit and the filtering unit.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202311649177.XA CN117481660A (en) | 2023-12-05 | 2023-12-05 | Implantable multipurpose electroencephalogram signal acquisition system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202311649177.XA CN117481660A (en) | 2023-12-05 | 2023-12-05 | Implantable multipurpose electroencephalogram signal acquisition system |
Publications (1)
Publication Number | Publication Date |
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CN117481660A true CN117481660A (en) | 2024-02-02 |
Family
ID=89674565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202311649177.XA Pending CN117481660A (en) | 2023-12-05 | 2023-12-05 | Implantable multipurpose electroencephalogram signal acquisition system |
Country Status (1)
Country | Link |
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CN (1) | CN117481660A (en) |
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2023
- 2023-12-05 CN CN202311649177.XA patent/CN117481660A/en active Pending
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