KR101644551B1

KR101644551B1 - Guidewire and guidewire system

Info

Publication number: KR101644551B1
Application number: KR1020150065361A
Authority: KR
Inventors: 박석호; 박종오; 고성영; 최현철; 정세미; 이청; 고광준
Original assignee: 전남대학교산학협력단
Priority date: 2015-05-11
Filing date: 2015-05-11
Publication date: 2016-08-03

Abstract

A guide wire for tunneling, comprising: a guide wire body having a hollow slot formed therein; A stop portion accommodated in the slot so as to be movable back and forth; And a member having different flexibility, and includes a wire connected to an end of the stopper portion. According to the present invention, there is an advantage in that the distal end portion having a relatively high flexibility of the wire can be pulled in or out of the guide wire body according to the slot movement of the stop portion to control the ductility for steering the guide wire and the rigidity for tunneling

Description

[0001] GUIDEWIRE AND GUIDEWIRE SYSTEM [0002]

The present invention relates to a guidewire and a guidewire system, in particular, a guidewire that is easy to steer and tunnel in a blood vessel, and is monitored in real time during a procedure and easily enters a guidewire to a target site without damaging the vessel wall To a guide wire system.

Generally, a catheter is a flexible tube of a hollow shaft, and is a medical device used for delivering a drug to a local area or puncturing a lesion site by vascular diseases and specific lesions.

To reach the catheter, the catheter is inserted along the wire after reaching the desired site using a thin flexible wire called a guide wire. The insertion of the guidewire is performed by the doctor while viewing the X-ray screen while administering the contrast agent in the blood vessel in real time. In this process, it is difficult to steer the tip of the guide wire, which can take a lot of time, and the patient and the doctor are exposed to the X-ray for a long time and the X-ray exposure continues to increase. If the direction of the tip portion is not directed toward the center of the blood vessel, there is a problem that the inner wall of the blood vessel may be damaged and punctured during the procedure.

On the other hand, it has been reported from a paper related to the treatment of cardiovascular disease that chronic total occlusion (CTO) in which cardiovascular diseases are totally occluded by deposits and blood flow does not flow is found in 52% of patients with severe coronary artery disease have.

Generally, chronic complete stenosis occurs when lipid-rich cholesterol is deposited on the inner wall of the blood vessel and the lumen is occluded. The multilayered lipid and thrombotic complexes constituting the stenotic lesion thus formed are replaced with collagen as time passes, and these collagens form a multimolecular mass from a single molecule, and the collagenization and calcification ) To form a mechanically stable phosphorylated layer to prevent blood circulation.

As a method of treating such chronic stricture, a method of chemically decomposing and reperfusion the fibrin-collagen complex of the stenotic portion and a method of physically perforating the fibrin-collagen complex have been used.

Conventional examples for perforating a chronic stricture lesion include laser angioplasty (laser angioplasty), which uses a laser to instantaneously vaporize and remove materials at the site of stenosis, and high-speed rotating diamond burr, There is a rotational antherectomy. Generally, it is known that rotary cutting method is useful for hardened stricture lesions with calcification. In addition, typical instruments of conventional chronic stricture treatment use high sharpness wire with high stiffness.

As a conventional technique, Japanese Patent Application Laid-Open No. 10-2010-0095782 proposes a device for removing a chronic stricto-striction lesion in a blood vessel. The apparatus includes a potential adjusting unit having a lesion removing tool at a front end portion of a catheter that enters the lumen of a vessel and having a plurality of balloons and a posterior adjusting unit to adjust the position of the lesion removing tool to remove a chronic stricture lesion in the blood vessel I would like to.

As described above, the catheter and the guide wire for tunneling require an excellent operability so that they can reach the target point through the thin and complicated pattern vascular system and the built-in system. The guidewire with a high-rigidity sharp end should not damage the vessel during movement to the target site and should be able to push the wire strongly to puncture at the target point.

Conventional catheterization using a guide wire was performed by inserting a flexible guide wire for steering to the target point and replacing it with a stiff-wire for tunneling when the target point was reached. As described above, the guide wire for tunneling needs properties of ductility for steering and rigidity required for tunneling so that the direction can be arbitrarily adjusted.

Korean Patent Publication No. 10-2010-0095782, Korean Patent Publication No. 10-2012-0124572

An object of the present invention is to provide a guidewire that is excellent in steering ability so as to be able to reach a target point efficiently, and enables tunneling treatment by increasing rigidity during lesion treatment. More specifically, the present invention seeks to provide a guidewire system capable of steering to an externally applied magnetic field and maintaining the rigidity of the guidewire at the target point.

In addition, the present invention provides a system in which monitoring is performed in real time during a procedure using a guide wire, and a guide wire can be easily introduced to a target site without damaging a blood vessel wall.

According to an aspect of the present invention, there is provided a tunneling guide wire comprising: a guide wire body having a hollow slot formed therein; A stop portion accommodated in the slot so as to be movable back and forth; And a member having a different flexibility from each other, and a wire connected to the end of the stopper.

Preferably, the wire can be pulled in or out of the guidewire body as the distal portion, which is relatively flexible, moves with the movement of the stop.

Preferably, the guide wire body has a magnetic body and can be steered by a magnetic field applied from the outside.

Preferably, the stop is a rod connected with a wire; And a stop head formed on the top of the rod with a larger diameter than the rod such that the rod is not released out of the guide wire body.

Preferably, the wire can be connected to the end of the stop portion with the distal portion being relatively flexible being disposed at the distal end.

Further, the present invention provides a guide wire system comprising: a rotary arm provided with a first C arm and a second C arm orthogonal to each other and rotatable about a horizontal axis with respect to the ground; An image capturing unit installed at each end of the first C arm to obtain a video image; A magnetic field generator having a pair of coils provided at respective ends of the second C arm so as to face each other and a power supply unit for supplying a magnetizing current for generating an induced magnetic field to the coil; A guide wire provided with a magnetic body to perform steering drive by a magnetic field generated by a magnetic field generating unit; And a guide wire feeding unit for controlling insertion of the guide wire.

The guide wire according to the present invention is advantageous in that the flexibility for the steering of the guide wire and the rigidity for the tunneling can be controlled by a member of relatively low flexibility of the wire being pulled in or drawn out from the guide wire body according to the slot movement of the stopper have. Accordingly, the guide wire according to the present invention has a simple structure that is easy to manufacture, and can control the rigidity of the guide wire itself during steering and tunneling.

The guide wire system according to the present invention is advantageous in that it can be efficiently disposed without interference between the image pickup means for obtaining the image in real time and the magnetic field generating unit for guiding the guide wire to the lesion position using the induction magnetic field have.

Further, the guide wire system according to the present invention changes the induced magnetic field by using the detection signal of the F / T sensor part which can detect the reaction force due to contact with the blood vessel wall in the insertion process of the guide wire, There is an advantage that damage can be prevented. This is advantageous in that the guide wire can be efficiently positioned to the target point of the blood vessel and the lumen without requiring a high degree of proficiency of the practitioner as compared with the conventional steering method using the manual guide wire.

Next, the guidewire system according to the present invention can remotely control and insert the guide wire to the lesion site in a short period of time. Therefore, It has the advantage of reducing X-ray exposure.

1 shows a configuration diagram of a guide wire and a guide wire system according to an embodiment of the present invention.
FIG. 2 shows a state in which the guide wire according to the embodiment of the present invention is controlled so as to be able to steer and tunnel with a single wire as the stopper moves. FIG. 2A shows a state in which a member having a high flexibility of a wire is pulled out to adjust the direction of the guide wire, and FIG. 2B shows a state in which a member having high flexibility of a wire is inserted and rigidity for tunneling is transmitted to the guide wire.
3 is a view showing an embodiment of a guide wire feeding unit in the guide wire system according to the present invention.
4 (a), 4 (b), 4 (c) and 4 (d) illustrate operation examples of the guide wire in the guide wire system according to the present invention.
FIG. 5 is a view showing another embodiment of the guide wire to be steered in the guide wire system according to the present invention. FIG.
6 (a), 6 (b), 6 (c) and 6 (d) illustrate examples of wire manipulation using the guide wire system according to the present invention.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings. However, the present invention is not limited to or limited by the exemplary embodiments. Like reference numerals in the drawings denote members performing substantially the same function.

The objects and effects of the present invention can be understood or clarified naturally by the following description, and the purpose and effect of the present invention are not limited by the following description.

The objects, features and advantages of the present invention will become more apparent from the following detailed description. In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail.

1 shows a configuration diagram of a guide wire 10 and a guide wire system according to an embodiment of the present invention. Referring to FIG. 1, a guide wire system according to an embodiment of the present invention includes a rotary arm 110 having a first C arm 111 and a second C arm 112, which are perpendicular to each other, ; An image capturing unit 121 (122) provided at each end of the first C arm 111 to obtain a video image; A pair of coils 131 and 132 provided at the respective ends of the second C arm 112 so as to face each other and a power supply unit 130 for supplying a magnetizing current for generating an induction magnetic field to the coils 131 and 132 133); A movable bed (140) disposed adjacent to the rotary arm (110) and capable of moving back and forth; A guide wire (10) connected to the tip so that the steering drive is performed by the magnetic field generated by the magnetic field generator; And a guide wire feeding unit (200) provided with a wire (105).

The rotary arm 110 is provided with two C arms 111 and 112 orthogonal to each other so as to be integrally rotated, and the base member 101 may be provided so that the rotary member 110 is rotated with a horizontal axis with respect to the ground surface. Each C arm has a "C" shape with a certain curvature and has opposite ends facing each other.

The rotary arm 110 is provided on the base member 101 with an electric drive unit, and thus the rotary arm 110 can be rotationally driven by an external electric power source or a drive signal.

The image capturing units 121 and 122 are provided at each tip of the first C arm to obtain an image image. Preferably, the image capturing units 121 and 122 include an X-ray source 121 and an X- Ray detector 122 provided opposite to the X-ray detector 121.

The magnetic field generation unit includes a pair of coils 131 and 132 provided at the respective ends of the second C arm so as to face each other and a power supply unit 132 for supplying a magnetizing current for generating an induction magnetic field to the coils 131 and 132 133).

The pair of coils 131 and 132 may be provided by a Helmholtz coil which generates a uniform magnetic field with the same circular coil.

The movable bed 140 is positioned above the support structure 141 and is rotatable about the longitudinal and longitudinal directions. Meanwhile, the movable bed 140 may be provided with a separate electric driving unit, and may be rotated forward or backward by the driving unit.

The guide wire feeding unit 200 can control the guide wire 10 provided with a magnetic body at its tip end. The guide wire 10 is steered by a magnetic field generated by the pair of coils 131 and 132.

Fig. 2 shows a state in which the guide wire 10 according to the embodiment of the present invention is controlled so as to be able to be steered and tunneled to the single wire 105 in accordance with the movement of the stopper portion 103. Fig. 2A shows a state in which a highly flexible member 1051 of a wire 105 is pulled out to adjust the direction of the guide wire body 101. FIG. 2B shows a state in which a member 1051, And shows a state in which rigidity for tunneling is transmitted to the body 101. FIG.

2, the guide wire 10 may include a guide wire body 101, a stop 103, and a wire 105 for insertion and steering of the guide wire 10, which are inserted into the bar. The guide wire body 101 may have a hollow slot 1013 formed therein. The slots 1013 are passed through the lower surface of the guide wire body 101, and holes having different diameters are provided in two stages.

The wire hole 1013b formed at the end of the guide wire body 101 has a diameter corresponding to that of the wire 105 so that the wire 105 can be pulled in or pulled out. Above the wire hole 1013b, a hollow groove 1013a having a larger diameter and elongated along the length of the guide wire body 101 is formed.

The guide wire body 101 may have a magnetic body and be steered by a magnetic field applied from the outside. In the present invention, the magnetic body is not particularly limited as long as it includes permanent magnets and is magnetized in a magnetic field. In addition, the guide wire body 101 may be made of a magnetic substance separately or the body 101 itself may have a magnetic property. The process of controlling the direction to the magnetic field can be understood by the guide wire system described later.

The stopper portion 103 is accommodated in the slot 1013 so as to be movable back and forth. The stop portion 103 may include a rod 1031 and a stop head 1033 connected to the wire. The stop head 1033 is formed on the upper portion of the rod 1031 with a larger diameter than the rod 1031 so that the rod 1031 is not released to the outside of the guide wire body 101.

The rod 1031 is preferably formed to have a diameter capable of passing through the wire hole 1013b. The stop head 1033 is accommodated in the hollow groove 1013a and is formed to have a larger diameter than the wire hole 1013b.

The wire 105 may be provided by a flexible metal or synthetic resin material in the form of a spring. In this case, the wire 105 may be made of a different material in some sections. The wire 105 is characterized in that the material of the distal portion 1051 and the proximal portion 1053 connected to the stopper portion 103 are different from each other. Preferably, the distal portion 1051 can be made of a more flexible material compared to the proximal portion 1053. For example, a proximal portion 1053 of the wire 105 may be a metal material, and a distal portion 1051 may be a synthetic resin material.

The distal portion 1051 is disposed at the distal end of the wire 105 and is connected to the rod 1031. The distal portion 1051 which is relatively more flexible than the proximal portion 1053 can be pulled out or drawn out of the guide wire body 101 in accordance with the movement of the stopper portion 103. [

2A, when the stopper portion 103 is moved such that the stop head 1033 contacts the upper portion of the wire hole 1013b, the relatively flexible distal portion 1051 contacts the outer surface of the guide wire body 101 . When the distal portion 1051 having flexibility is drawn out of the guide wire body 101, the guide wire body 101 has an advantage that the effective steering angle range can be increased by the induction magnetic field at the end of the wire 105. [

2B, when the stopper 103 is moved so as to be in close contact with the bottom surface of the hollow groove 1013a, the distal portion 1051 having a relatively high flexibility is drawn into the inside of the guide wire body 101. When the flexible distal portion 1051 is drawn into the interior of the guidewire body 101, the guidewire body 101 may receive the rigidity of the relatively less flexible proximal portion 1053 at the distal end of the wire 105 .

The guidewire 10 according to the present embodiment includes the body 101 of the hollow slot 1013 and the wire 105 connected to the stop 103 so that the guidewire 10 is inserted into the guide wire body 101 The transmitted rigidity can be adjusted. That is, in the process of moving the guide wire body 101 to a treatment point where lesions are present, the operator can drive the guide wire body 101 in the same manner as in the embodiment of FIG. 2A, thereby improving the steering angle range of the guide wire body 101. Or when the guide wire body 101 reaches the treatment point, the guide wire body 101 can be delivered with sufficient rigidity for tunneling by driving as in the embodiment of FIG. 2B.

Unlike the prior art in which a highly flexible guide wire is first inserted for steering to a target point and a catheter is inserted along the guide wire, the guide wire 10 according to the present embodiment can adjust its rigidity It is possible to perform the procedure without replacing the guide wire.

3 is a view showing an embodiment of a guide wire feeding unit in the guide wire system according to the present invention.

3, the guide wire feeding unit 200 includes an F / T sensor unit 220 for detecting a force and a torque applied to the wire 210, And a control unit 230 for varying an induced magnetic field generated in the magnetic field generating unit according to the signal.

For example, when the guide wire 210 is inserted into the blood vessel and contacts the blood vessel wall, the F / T sensor unit 220 detects the reaction force and transmits the detected reaction force to the control unit 230, The magnitude of the induced magnetic field generated in the magnetic field generating unit is adjusted according to the magnitude of the reaction force, so that insertion can be performed without damaging the blood vessel wall at the time of inserting the guide wire 210.

Meanwhile, the control unit 230 changes the rotation angle of the rotary arm 110 to change the steering angle of the tip of the guide wire 210 according to the force and torque detected by the F / T sensor unit 220, The direction of the generated induced magnetic field can be changed. On the other hand, the control unit 230 may change the steering angle of the distal end 211 of the guide wire 210 by changing the rotation angle of the movable bed 140 separately from the rotational driving of the rotary arm 110.

A wire connection part 221 may be provided between the F / T sensor part 220 and the guide wire 210. A guide wire 210 may be press-fitted into the front end of the wire connection part 221. [ The reaction force of the tip of the guide wire 210 generated by inserting the guide wire 210 into the human body is transmitted to the F / T sensor unit 220 through the wire connection unit 221, A supporter 222 can be provided.

The F / T sensor unit 220 is installed in the rotation driving unit 240 and can be rotated by the rotation driving unit 240 to rotate the guide wire 210. The rotary drive unit may be provided by an electric motor, or a known transmission such as a stepping motor.

The rotation driving unit 240 may include a linear driving unit 250 and may be operated in the forward and backward directions of the linear driving unit 250. The linear driving unit may include a linear motor, May be provided by various actuators.

Reference numeral 201 denotes a base plate on which the guide wire feeding unit is installed, and the base plate may be a structure provided on the movable bed, or may be a structure provided separately from the movable bed.

4 (a), 4 (b), 4 (c) and 4 (d) are views showing examples of operation of the guide wire in the guide wire system according to the present invention.

4 (a) and 4 (b), the magnitude of the induced magnetic field differs according to the magnitude of the magnetizing current I1 <I2 applied to the coils 131 and 132. At this time, the magnitude of the steering angle of the guide wire 210 is And increases in proportion to the magnitude of the induced magnetic field.

4 (c) and (d), the steering direction of the guide wire 210 can be changed according to the direction of the magnetizing current applied to the coils 131 and 132.

Fig. 5 is a view showing another embodiment of a guide wire to be steered, according to the present invention. Fig.

As illustrated in FIG. 5, the guide wire 220 can steer the guide wire body 211 at a large angle by using a material having a more flexible material of the distal portion 212b than the proximal portion 212a of the connected wire.

6 (a), 6 (b), 6 (c) and 6 (d) are views for explaining an example of wire operation using the guide wire system according to the present invention. The present invention can be performed while monitoring a video image obtained in the video radiographing units 121 and 122 in real time and can be performed in a video image obtained through the video radiographing units 121 and 122, 105, the guide wire body 101, and the like.

The end of the wire 105 connected to the guide wire body 101 is appropriately steered along the blood vessel through intensity and direction control of the magnetizing current applied to the coil while referring to the image of the image so that the guide wire body 101 is moved to the lesion position You can.

Meanwhile, the force and torque detected by the F / T sensor unit 220 in the process of inserting the guide wire 210 are transmitted to the control unit 230. The control unit 230 detects the force and torque from the F / T sensor unit 220, And the contact state of the contact. The control unit 230 controls the power supply unit 133 to adjust the induced magnetic field generated in the coils 131 and 132 to prevent damage to the blood vessel wall.

On the other hand, when the guide wire body 101 is relatively inserted along the blood vessel of the straight section as shown in Figs. 6 (a) and 6 (c), the induction magnetic field need not be generated. At a position where the direction of the guide wire 10 is required to be switched, an induction magnetic field is generated and the guide wire body 101 can be steered.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. will be. Therefore, the scope of the present invention should not be limited to the above-described embodiments, but should be determined by all changes or modifications derived from the scope of the appended claims and equivalents of the following claims.

10: guide wire 101: guide wire body
1011: Tip 1013: Slot
1013a: hollow groove 1013b: wire hole
103: stopper 1031: rod
1033: stop head 105, 210, 310: wire
1051: A relatively flexible distal
1053: A relatively inflexible proximal
110: rotating arm 111: first C arm
112: second C arm 121: X-ray source
122: X-ray detector 131, 132: coil
133: Power supply unit 140: Operation bed
200: guide wire feeding unit 211: guide wire
220: F / T sensor unit 230:
240: rotation driving part 250: linear driving part

Claims

A guide wire body having a hollow slot formed therein;
A stop portion accommodated in the slot so as to be movable back and forth; And
And a wire connected to an end portion of the stop portion,
Wherein the wire is pulled in or out of the guidewire body in accordance with the movement of the stopper portion.

The method according to claim 1,
Wherein the guide wire body comprises:
And is guided by a magnetic field applied from the outside with a magnetic body.

The method according to claim 1,
Wherein,
A rod connected to the wire; And
And a stop head formed on an upper portion of the rod with a larger diameter than the rod such that the rod is not released to the outside of the guide wire body.

The method according to claim 1,
The wire
Wherein a relatively flexible distal portion is disposed at the tip and connected to the end of the stop.