KR101633998B1 - Ａｄｈｄ 검출용 바이오마커 - Google Patents

Abstract

본 발명은 ADHD 검출용 조성물, 키트, ADHD를 확인하기 위한 정보 제공 및 ADHD 약물을 스크리닝하는 방법에 관한 것이다. 본 발명에 따른 유전자 마커를 이용한 ADHD 검출용 조성물은 ADHD를 효과적으로 검출할 수 있을 뿐만 아니라 이의 대표적 증상인 과잉행동, 주의력 또는 집중력 결핍 및 충동행동과 관련된 유전자 마커를 이용하여 행동학적 특성을 유전적으로 효과적으로 검출할 수 있으므로 ADHD를 조기에 진단하고 ADHD를 치료하기 위한 약물의 스크리닝에 이용할 수 있다.

Description

ＡＤＨＤ 검출용 바이오마커{Biomarkers for detection of ADHD}

본 발명은 ADHD 검출용 조성물, 키트 및 ADHD를 확인하기 위한 정보를 제공하는 방법에 관한 것이다.

주의력결핍/과잉행동장애{이하, ADHD (Attention Deficit/Hyperactivity Disorder)}란 과잉행동, 주의력 결핍 및 충동 행동성을 핵심 증상으로 하는 대표적 뇌발달 장애 질환으로 소아부터 성인까지 지속적인 치료가 요구되는 질환이다. 국내의 경우, 초등학생의 약 7-10%, 중-고등학생의 약 5%에서 나타나며, 성인의 약 2-3%에서 이환되고, 기분장애, 물질 및 행위중독증과 높은 공존율을 보인다.

ADHD 환자는 핵심 증상에 수반하는 학습장애, 품행장애, 우울증, 수면장애 등의 정신과적 장애를 동반하고, 불순종, 공격성, 반사회적인 행동을 보이기 때문에 사회적인 적응이 어렵고 양육 스트레스를 유발하여 가정과 사회에서 상호관계의 악순환을 유발한다. 뿐만 아니라 ADHD 환아는 주의가 산만하고 집중력의 지속성이 감소되어 있음으로, 교통사고 등 사고에 취약하며 공격적이고 반항적 행동을 보여 청소년 비행이나 약물남용을 유발할 수 있어 왕따 등의 사회적 문제와도 연결되어 있다. 또한, ADHD 증세가 있는 경우 정상적인 사회관계 정립 및 학습능력에도 문제를 드러내며 성인도 약물 중독 및 실행 능력 부족 등의 문제를 보이며 특히, 일반 성인에 비하여 흡연률이 높게 나타난다. ADHD는 성인기까지 지속되는 비율이 40~60%로 직업 유지 및 결혼생활의 어려움을 겪을 뿐 아니라 알코올을 비롯한 약물 남용 및 의존, 반사회적 행동, 비행, 범죄의 가능성이 높아지고, 학교폭력 및 왕따 문제, 청소년의 자살 등과 관련한 문제점들이 ADHD와 흔히 공존해서 나타난다. 이에 따라 환자 1인당 평생 손실액이 1억원, 부모의 작업손실액이 1조 6천억원에 달하며, 대상질환의 규모 및 심각성, 개입효과가 소아청소년 정신질환 중 제1순위로 가장 높다. 이와 같은 높은 사회경제적 비용과 일생에 걸친 영향에도 불구하고 다른 주요정신질환인 우울증이나 정신분열병에 비해 ADHD에 대한 국가·사회적 대책은 미흡한 실정이다.

ADHD의 신경학적 기전에 대해선 카테콜아민인 노르에피네프린(이하 NE)과 도파민(이하 DA)의 변화와 관련하여 주로 연구가 진행되었고, 동물연구에서 실행능력의 조절에 NE와 DA가 중요한 역할을 하는 것으로 밝혀져 있다. ADHD의 신경병리 및 약리를 이해하기 위해 유전자 조작 및 선택적 교배 방법으로 다양한 동물모델들이 개발되어 왔다. 임상연구에서 다수의 ADHD 치료제들이 교감신경계에 영향을 미치는 것으로 확인되었으며, 특히, 메칠페니데이트와 암페타민과 같은 중추신경자극제는 각각 NE와 DA의 재흡수를 차단하고, 아토목세틴은 강력한 NE 재흡수 차단 작용을 하는 것으로 알려져 있다. Usher등의 (1999)의 연구에 의하면 영장류의 청반 신경에서 NE 활성이 우울 및 주의력결핍과 관련이 있는 것으로 밝혀졌고, Berridge (2001)는 NE가 관련 자극에 대한 반응을 증가시킨다고 발표하였다. 도파민 신경계와 관련하여, ADHD 증상이 있는 경우 뇌척수액에서 도파민 주요 대사체인 호모바닐린산(이하 HVA)이 증가하고 중추신경자극제 치료 시 감소하였다.

유전자 조작을 통해 특정 신경분자의 일부를 제거한 생쥐 연구에서 카테콜아민합성효소인 타이로신하이드록실라제(tyrosine hydroxylase), 제1형, 2형 및 4형 도파민수용체 제거 생쥐의 운동활성이 감소함을 확인하였다. 출생전 저산소노출 동물 및 자발성고혈압쥐(SHR) 등의 동물 모델이 광범위하게 ADHD의 동물모델로 사용되고 있고, 이들 ADHD 동물 모델을 통한 여러 연구에서 도파민성 신경계에 문제가 있는 것으로 밝혀졌다. ADHD는 유전적 소인이 중요한 질환이지만 멘델의 법칙을 따르지는 않으며 복잡한 표현형(Phenotype)을 나타낸다. 일반적으로 유전학에서 사용되는 기법과 같이 각 질병의 원인에 대하여 하나의 유전자를 동정하거나 특이한 기능성 단백질의 이상을 발견하는 멘델식의 (단일유전자적) 접근은 주의력결핍-과잉행동장애와 같은 복잡하고 편향된 행동을 주문제로 보이는 정신장애에 있어 그대로 적용하기란 사실상 불가능하며, 다양한 유전적 영향의 상호작용으로 보고 접근하는 것이 보다 타당하다.

최근의 연구들은 ADHD가 유전적 요소가 매우 강하며 가족력이 있다고 밝히고 있고, 쌍생아 연구와 입양 연구로부터 얻어진 광범위한 데이터로부터 ADHD는 약 75%의 유전율이 있다고 보고된 바 있다. 원인적으로도 유전적ㆍ발달학적 위험요인(병인)이 뇌구조-기능의 이상을 초래하고, 핵심적 신경인지기능의 이상을 불러일으켜 주의력결핍ㆍ과잉행동ㆍ충동성이라는 표현형으로 나타나는 것으로 여겨지고 있으므로 ADHD의 핵심신경인지결함의 분자생물학적 기전의 개별성과 복합성을 유전학적 방법으로 규명할 필요가 있다. 지금까지 수많은 후보유전자에 대한 연구가 진행되어 왔고, 연구가 늘어나고 있는 상태이지만 (Swanson 등, 2000), 주된 연구는 카테콜아민계와 세로토닌계에 대하여 이루어져 왔고 이는 주의력결핍-과잉행동장애의 약물요법에서 사용되는 약물들이 대부분 도파민계의 신호전달 활성화를 통하여 작용한다고 생각되었기 때문이다. 분자유전학적 연구는 각종의 연관과 상관관계 (Linkage and Association)를 탐구하여 특정 질환을 유발하는 유전자를 확인하는 것을 최종적 목표로 하는 연구 방법이며, 이를 활용하여 약물학적 연구와 동물모형의 연구를 기초로 ADHD의 유전적 취약성을 설명할 수 있는 후보 유전자 연구를 확대할 필요가 있다. 동물모형의 설정에서 가장 어려운 점은 다양하게 발현되는 인간행동에 대하여 동등한 동물행동을 정의하기가 어렵다는 점이지만, ADHD의 주된 증상군인 집중력 또는 주의력결핍, 충동성 및 과잉행동 그리고 수반되는 인지기능의 결손은 어느 정도 외형적으로 유사하다. 대표적인 모형은 2번 염색체의 이상으로 인하여 SNAP-25 유전자와 기타의 유전자 변형을 보이는 coloboma 생쥐모형, Wistar Kyoto(이하 WKY) 종에서 유래된 자발성고혈압쥐 (SHR), 도파민수송체(DAT) 결손생쥐(DAT-knockout mice)와 도파민신경소작쥐(Dopamine lesioned rat) 등이다.

자발성 고혈압 쥐모형(Spontaneously Hypertensive Rat, 이하 SHR)은 지금까지 가장 많이 연구되고, 안면타당도, 구조타당도, 그리고 예측 타당도를 만족시키는 모델이다. 여러 연구에서 도파민성 및 노르에피네프린성 신경계에 문제가 있는 것으로 밝혀졌고, 다른 정상적인 쥐에 비해 집중력과 학습 능력에 손상이 있으며 충동적인 성향을 나타낸다. 위에 서술한 모델을 포함하여 ADHD 연구를 위해 유전자 조작 및 선택적 교배 방법에 의한 유전적 모델과 환경적 조작으로 인한 후천성 환경모델 등 약 23종의 다양한 동물모델들이 개발되어 사용되고 있으나 ADHD 원인의 다양성과 마찬가지로 모든 조건을 완벽히 만족하는 동물 모델이 존재하지 않고, ADHD 행동증상의 발현을 전적으로 지지하는 이상 유전자도 밝혀지지 않았다.

ADHD와 같은 뇌신경발달질환의 경우 직접적인 조직 적출을 통한 검사가 어렵기 때문에 혈액을 이용한 진단법 개발에 대한 필요성이 매우 크다. 이와 관련해서 Single association study부터 genome wide association study까지의 수많은 임상 유전연구가 진행되고 있으나 재현성 문제, 가양성/가음성 결과의 문제 및 실질적 생물학적 의미 부재에 대한 문제가 지속되고 있다. 따라서 보다 많은 환자군에 적용할 수 있는 유전학적 원인가설들과 이에 대한 긍정적인 결과재현이 요구되고 있으며 이러한 결과의 축적으로 인하여 향후 이 장애의 올바른 치료에 대한 발전이 필요한 상태이다.

따라서 본 발명은 ADHD 행동특성인 과잉 행동, 집중력 또는 주의력 결핍 및 충동 행동과 관련된 유전자 변화를 탐색하여, ADHD 검출용 바이오마커 및 이를 함유하는 ADHD 검출용 조성물, 키트, ADHD 를 확인하기 위한 정보 제공 및 ADHD 치료 약물을 스크리닝 하는 방법을 제공하는 것을 목적으로 한다.

상기 목적을 달성하기 위하여 본 발명자들은 ADHD 랫트 모델을 이용하여 그의 행동학적 증상을 분석하고 이에 따른 ADHD의 과잉행동, 집중력 또는 주의력 결핍, 충동행동과 관련된 유전자 마커들을 확인하고 본 발명을 완성하였다.

따라서 본 발명은 ADHD (Attention Deficit/Hyperactivity Disorder) 증상과 관련된 서열번호 1 내지 47에 기재된 유전자군으로부터 선택된 하나 이상의 유전자로 이루어진 바이오 마커, 상기 유전자에 특이적인 핵산 또는 올리고뉴클레오티드, 또는 상기 유전자가 암호화하는 단백질에 특이적인 항체를 포함하는, ADHD 검출용 조성물을 제공한다.

또한 본 발명은 상기 조성물을 포함하는 ADHD 검출용 키트를 제공한다.

또한 본 발명은 대상체와 정상 대조군로부터 분리된 RNA 시료 중 제1항에 기재된 바이오마커의 발현 정도를 비교하는 것을 포함하는, ADHD 를 확인하기 위한 정보를 제공하는 방법을 제공한다.

또한 본 발명은 ADHD로 판명된 대상체에 ADHD 약물 후보군을 처리한 후, 표 1a에 기재된 유전자로 이루어진 군에서 선택된 1종 이상의 유전자 발현의 변화를 분석하는 단계;를 포함하는 ADHD 치료 약물을 스크리닝하는 방법을 제공한다.

본 발명에 따른 유전자 마커를 이용한 ADHD 검출용 조성물은 ADHD를 효과적으로 검출할 수 있을 뿐만 아니라 이의 대표적 증상인 과잉행동, 집중력 또는 주의력 결핍 및 충동행동과 관련된 유전자 마커를 이용하여 행동학적 특성을 유전적으로 효과적으로 검출할 수 있으므로 ADHD를 조기에 진단하고 ADHD를 치료하기 위한 약물의 스크리닝에 이용할 수 있다.

도 1은 SHR 랫트, WKY 랫트, 위스타 랫트에 약물을 처리하고 중추신경계 흥분성 동물 모델에서 행동 특성 및 유전자 발현 분석을 수행하기 위한 실험 스케쥴을 간략히 나타낸 도이다.
도 2는 ADHD의 과잉행동을 평가하기 위하여, 일반 운동 활성 시험을 수행한 결과를 나타낸 도이다.
도 3 내지 도 5는 집중력 및 주의력 결핍을 확인하기 위한 Y-maze 시험 결과를 나타낸 도이다.
도 6은 ADHD 증상 중 충동성을 평가하기 위한 방법을 나타낸 모식도이다.
도 7 내지 도 9는 ADHD 증상 중 충동행동 특성을 평가한 결과를 나타낸 도이다.

본 발명은 ADHD (Attention Deficit/Hyperactivity Disorder) 증상과 관련된 서열번호 1 내지 47 에 기재된 유전자군으로부터 선택된 하나 이상의 유전자로 이루어진 바이오 마커, 상기 유전자에 특이적인 핵산 또는 올리고뉴클레오티드, 또는 상기 유전자가 암호화하는 단백질에 특이적인 항체를 포함하는, ADHD 검출용 조성물을 제공한다.

상기 유전자 마커를 이용한 ADHD 검출용 조성물은 ADHD를 효과적으로 검출할 수 있을 뿐만 아니라 이의 대표적 증상인 과잉행동, 집중력 또는 주의력 결핍 및 충동행동과 관련된 유전자 마커를 이용하여 행동학적 특성을 효과적으로 검출할 수 있으므로 ADHD를 조기에 진단하고 ADHD를 치료하기 위한 약물의 스크리닝에 이용할 수 있다.

상기 서열번호 1 내지 47에 기재된 유전자군은 ADHD 행동특성을 나타내는 동물 모델에서 대조군의 유전자 발현값과 비교하여 차별적으로 발현되는 유전자들로, 발현정도 측정을 통해 ADHD를 효과적으로 검출할 수 있다.

또한 본 발명은 서열번호 1 내지 27로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커에 관한 것이며, 이러한 바이오마커로 이루어지며 ADHD 의 과잉행동 증상을 검출하기 위한 것인 ADHD 검출용 조성물을 제공한다.

상기 서열번호 1 내지 27의 바이오마커들은 ADHD의 대표적인 증상 중 과잉행동과 관련된 유전자이며 과잉행동을 나타내는 ADHD 환자에서 증가하거나 감소한 발현 양상을 나타낸다.

또한 본 발명은 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 32로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커에 관한 것이며, 이러한 바이오마커로 이루어지며 ADHD 의 집중력 또는 주의력 결핍을 검출하기 위한 것인 ADHD 검출용 조성물을 제공한다.

상기 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 32로 이루어지는 바이오마커들은 ADHD의 대표적인 증상 중 집중력 또는 주의력 결핍과 관련된 유전자이며 집중력 또는 주의력 결핍을 나타내는 ADHD 환자에서 증가하거나 감소한 발현 양상을 나타낸다.

또한 본 발명은 서열번호 1, 2, 8, 9, 16 내지 18, 서열번호 25 내지 27, 및 서열번호 33 내지 47로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커에 관한 것이며, 이러한 바이오마커로 이루어지며 ADHD 의 충동행동을 검출하기 위한 것인 ADHD 검출용 조성물을 제공한다.

상기 서열번호 1, 2, 8, 9, 16 내지 18, 서열번호 25 내지 27, 및 서열번호 33 내지 47로 이루어진 바이오마커들은 ADHD의 대표적인 증상 중 충동행동과 관련된 유전자이며 충동행동을 나타내는 ADHD 환자에서 증가하거나 감소한 발현 양상을 나타낸다.

또한 본 발명은 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 27로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커에 관한 것이며, 이러한 바이오마커로 이루어지며 ADHD 의 과잉행동 및 집중력 또는 주의력 결핍을 검출하기 위한 것인 ADHD 검출용 조성물을 제공한다.

상기 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 27로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커들은 ADHD의 대표적인 증상 중 과잉행동 및, 집중력 또는 주의력 결핍과 관련된 유전자이며 과잉행동과 집중력 또는 주의력 결핍을 동시에 나타내는 ADHD 환자에서 증가하거나 감소한 발현 양상을 나타내므로 두가지 증상을 효과적으로 검출할 수 있다.

또한 본 발명은 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 27로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커에 관한 것이며, 이러한 바이오마커로 이루어지며 ADHD 의 과잉행동, 집중력 또는 주의력 결핍 및 충동행동으로 이루어진 군에서 선택된 1종 이상의 증상을 동시에 검출하기 위한 것인 ADHD 검출용 조성물을 제공한다.

상기 서열번호 1, 2, 8, 9, 16 내지 18 및 서열번호 25 내지 27로 이루어진 군에서 선택된 1종 이상의 유전자로 이루어지는 바이오마커들은 ADHD의 대표적인 증상 중 과잉행동, 집중력 또는 주의력 결핍 및 충동행동과 관련된 유전자이며 과잉행동, 집중력 또는 집중력 또는 주의력 결핍, 충동행동을 동시에 나타내는 ADHD 환자에서 증가하거나 감소한 발현 양상을 나타내므로 세가지 증상 모두 또는 이러한 증상 중 선택된 1종 이상을 효과적으로 검출할 수 있다.

본 발명에서 유전자에 특이적인 핵산 또는 올리고폴리펩티드는 프라이머 또는 프로브일 수 있으며, DNA 및/또는 RNA 등의 유전자와 상보적인 서열을 갖거나, 혼성화가 가능하다.

상기 프라이머는 템플레이트(template)와 상보적으로 결합할 수 있고, 역전사효소 또는 DNA 중합효소가 템플레이트의 복제를 개시할 수 있도록 하는 자유 3말단 수산화기(free 3' hydroxyl group)를 갖는 핵산 서열을 의미한다. 프라이머는 특정 유전자의 핵산 서열에 상보적인 서열을 가지는 뉴클레오티드로서, 약 7bp 내지 50bp의 길이, 바람직하게는 약 10 bp 내지 30 bp의 길이를 갖는다. 상기 프라이머는 DNA 합성의 개시점으로 작용하는 프라이머의 기본 성질을 변화시키지 않는 추가의 다른 염기 서열을 포함할 수도 있다. 프라이머는 널리 공지된 방법을 사용하여 화학적으로 합성할 수 있으며, 이러한 핵산 서열은 또한 당해 분야에 공지된 많은 수단을 이용하여 변형시킬 수 있다.

상기 프로브는 표적 핵산과 부분적으로 또는 완전히 상보적인 핵산 가닥으로서, 표적 핵산과 염기 특이적인 방식으로 결합할 수 있는 올리고뉴클레오티드이다. 바람직하게는, 표적 핵산에 완전 상보적인 올리고뉴클레오티드이다. 상기 프로브는 핵산뿐만 아니라, 펩티드 핵산을 포함한 상보적 결합을 할 수 있는 종래 알려진 임의의 핵산 유도체가 포함된다. 상기 프로브와 표적 핵산의 결합 (일반으로, 혼성화라고도 함)은, 서열 의존적으로 일어나는 것으로 다양한 조건에서 수행될 수 있다. 일반적으로 혼성화 반응은 특정한 이온 강도 및 pH에서 특정 서열에 대한 Tm 보다 약 5℃ 낮은 온도에서 이루어진다. 상기 Tm 은 표적 서열에 상보적인 프로브의 50%가 표적 서열에 결합한 상태를 의미한다. 혼성화 반응 조건의 예는, pH 7.0 내지 8.3, 0.01 내지 1.0M Na⁺ 이온 농도일 수 있다. 또한, 표적 핵산과 프로브의 특이성을 높이기 위하여, 표적 핵산과 프로브의 결합을 불안정하게 하는 조건, 예를 들면, 높은 온도, 높은 농도의 불안정화제(예를 들면 포름아미드)의 존재 등을 피하여 수행될 수 있다. 상기 프로브의 길이는 표적 핵산과 서열 특이적으로 결합할 수 있는 것이며, 어떠한 길이의 폴리뉴클레오티드도 포함된다. 예를 들면, 상기 프로브의 길이는, 10 내지 200 뉴클레오티드, 10 내지 150 뉴클레오티드, 10 내지 100 뉴클레오티드, 10 내지 50 뉴클레오티드, 또는 전장 유전자의 일 가닥의 길이일 수 있으나, 이들 예에 한정되는 것은 아니다. 상기 프로브는 검출가능한 표지로 표지된 것일 수 있다. 상기 검출 가능한 표지는 SYBR Green I 또는 각종 프로브(TaqMan Probe)의 5'-말단에는 형광물질인 FAM, 3'-말단에는 quencher인 TAMRA로 표지하고 이에 국한하지 않는다. Cy3 또는 Cy5와 같은 형광표지, 방사성 물질표지, 기질을 발색 물질로 전환시키는 효소 등이 포함되나, 이들 예에 한정되는 것은 아니다.

상기 프로브 또는 프로브 세트는 마이크로어레이에 고정화되어 있는 것일 수 있다.

시료 중의 바이오마커는 상기 마이크로어레이 중의 상기 프로브와 혼성화되고, 그 혼성화 결과를 측정함으로써 그 존재 여부 및 농도가 측정될 수 있다. 혼성화 과정 중 상기 표적 핵산은 검출가능한 표지로 표지될 수 있다.

상기 항체는 항원의 항원 결정기(epitope)에 특이적으로 결합할 수 있는 단백질을 의미하며, 다클론 항체, 단일클론 항체 및 재조합 항체를 포함한다. 상기 항체는 당업계에 널리 공지된 기술을 이용하여 용이하게 제조할 수 있다. 구체적으로, 상기 다클론 항체는 본 발명의 마커 유전자가 코딩하는 단백질 항원을 동물에 주사하고 동물로부터 채혈하여 항체를 포함하는 혈청을 수득하는 당업계에 널리 공지된 방법에 의해 생산할 수 있다. 이러한 다클론 항체는 염소, 토끼, 양, 원숭이, 말, 돼지, 소, 개 등의 다양한 동물 종 숙주로부터 제조 가능하다.

상기 항체는 2개의 전체 길이의 경쇄 및 2개의 전체 길이의 중쇄를 가지는 완전한 형태뿐만 아니라, 항체 분자의 기능적인 단편을 포함한다. 항체 분자의 기능적인 단편이란 항원 결합 기능을 보유하고 있는 단편을 뜻하며, Fab, F(ab'), F(ab')2 및 Fv 등이 있다.

본 발명은 또한 상기한 조성물을 포함하는, ADHD 검출용 키트를 제공한다.

상기 키트는 핵산 또는 항체 이외에 유전자 발현량이나 유전자 발현량이나 발현 패턴의 분석 방법 또는 단백질 존재량이나 존재 패턴의 분석 방법에 적합한 한 종류 또는 그 이상의 다른 구성 성분, 용액 또는 장치를 더 포함할 수 있다. 예를 들어, 상기 키트가 유전자의 발현량이나 발현 패턴을 검출하기 위한 키트인 경우에는, RT-PCR을 수행하기 위해 필요한 필수 성분을 포함하는 키트일 수 있으며, 이러한 RT-PCR 키트는 바이오마커 유전자의 mRNA에 대한 특이적인 각각의 프라이머 외에도 구체적인 실시 양상에 따라 예를 들어 테스트 튜브 또는 다른 적절한 컨테이너, 반응 완충액, 데옥시뉴클레오티드 (dNTPs), Taq-폴리머라제 및 역전사효소와 같은 효소, DNase, RNase 억제제 DEPC-수 (DEPC-water), 멸균수, 정량 대조군으로 사용되는 유전자에 특이적인 프라이머 쌍 등을 포함할 수 있다. 한편, 상기 키트가 단백질의 존재량이나 존재 패턴을 검출하기 위한 키트인 경우에는, 이 키트는 예를 들어 ELISA를 수행하기 위해 필요한 필수 성분을 포함하는 키트일 수 있으며, 이러한 ELISA 키트는 결합된 항체를 검출할 수 있는 성분들, 예를 들어 표지된 2차 항체, 발색단 (chromopores), 효소 (예를 들어, 항체와 접합된 효소) 및 그의 기질, 및 정량 대조군 단백질에 특이적인 항체 등을 포함할 수 있다. 구체적인 실시 양상에 따라서는, 상기 키트는 DNA 마이크로어레이 또는 단백질 마이크로어레이를 포함할 수 있다.

상기 유전자 발현량 또는 발현패턴은 DNA 마이크로어레이 뿐 아니라 해당 유전자의 전사로 인해 생성된 mRNA 양이나 패턴을 확인하는 통상적인 생화학적 분석방법으로 검출될 수 있다. 이러한 mRNA의 양이나 패턴을 확인하기 위한 분석 방법으로는 RT-PCR, 경쟁적 RT-PCR (Competitive RT-PCR), 실시간 RT-PCR (Real-time RT-PCR), RNase 보호 분석법 (RNase protection assay), 노던 블랏(Northern blot) 등이 있으며, 그 외에도 당업계에서 통상적으로 수행되는 어떠한 방법이라도 사용될 수 있다.

항체를 이용하여 단백질의 존재량이나 존재 패턴을 측정하는 방법으로는, 웨스턴 블랏, ELISA (enzyme linked immunosorbent assay), 방사선 면역분석 (Radioimmunoassay), 방사 면역 확산법 (radioimmunodiffusion), 오우크테를로니 (Ouchterlony) 면역 확산법, 로케트 (rocket) 면역 전기영동, 조직 면역 염색, 면역 침전 분석법(Immunoprecipitation Assay), 보체 고정 분석법 (Complement Fixation Assay), FACS, 단백질 칩 (protein chip) 등이 있으며, 그 외에도 당업계에서 통상적으로 수행되는 어떠한 방법이라도 사용될 수 있다.

바람직하게는, 본 발명에서 바이오마커의 발현 패턴의 확인은 마이크로어레이법, 보다 바람직하게는 DNA 마이크로어레이법일 수 있다.

본 발명은 또한 상기 기재된 하나 이상의 유전자로 이루어진 바이오마커의 핵산 서열; 그의 단편인 올리고뉴클레오티드; 또는 그에 상보적인 핵산 서열 또는 올리고뉴클레오티드가 집적된, ADHD 검출용 마이크로어레이 칩을 제공한다.

상기 마이크로어레이 칩은 또한 ADHD 검출 및 진단, 치료에 사용할 수 있다.

본 발명은 또한 대상체와 정상 대조군로부터 분리된 RNA 시료 중 서열번호 1 내지 47에 기재된 바이오마커의 발현 정도를 비교하는 것을 포함하는, ADHD 를 확인하기 위한 정보를 제공하는 방법을 제공한다.

상기 대상체에서 서열번호 1 내지 27 로 이루어진 군에서 선택된 1종 이상의 유전자의 발현이 대조군에 비하여 증가 또는 감소된 경우 대상체가 ADHD의 과잉행동 증상을 나타내는 것으로 판정할 수 있다.

또한 상기 대상체에서 서열번호 1, 2, 8, 9, 16 내지 18, 25 내지 32 로 이루어진 군에서 선택된 1종 이상의 유전자의 발현이 대조군에 비하여 증가 또는 감소된 경우 대상체가 ADHD의 집중력 또는 주의력 결핍 증상을 나타내는 것으로 판정할 수 있다.

또한 상기 대상체에서 서열번호 1, 2, 8, 9, 16 내지 18, 25 내지 27, 서열번호 33 내지 47 로 이루어진 군에서 선택된 1종 이상의 유전자의 발현이 대조군에 비하여 증가 또는 감소된 경우 대상체가 ADHD의 충동행동 증상을 나타내는 것으로 판정할 수 있다.

상기 대상체와 정상 대조군의 RNA 시료 중 바이오마커인 유전자의 발현 정도 비교는 당 분야의 통상의 기술을 이용하여 수행될 수 있으며, 바람직하게는 마이크로어레이 칩을 이용하여 수행된다.

마이크로어레이 칩을 이용한 비교 분석은 당 분야에서 통상적으로 사용되는 마이크로어레이법이 이용될 수 있으며, 그 일례로써, 대상체인 실험군과 정상 대조군으로부터 분리된 RNA 시료로부터 표지되거나 표지되지 않은 cDNA 또는 그의 단편인 올리고뉴클레오티드, 또는 그의 cRNA를 제조하여, 이를 본 발명의 바이오마커가 집적된 마이크로어레이 칩과 혼성화시키고, 반응한 마이크로어레이 칩을 분석하고, 분석 데이터에서 상기 마이크로어레이 칩상의 유전자 발현 정도를 대조군과 비교하여 대상체의 바이오마커 유전자들의 발현 변화를 측정함으로써 대상체의 ADHD를 검출하기 위한 정보를 얻을 수 있다. 이 때, 공지의 Affymetrix GeneChip Rat Genome 230 2.0 Array, Affymetrix의 Expression Console 프로그램 등이 사용될 수 있다.

본 발명은 또한 ADHD로 판명된 대상체에 ADHD 약물 후보군을 처리한 후, 서열번호 1 내지 47에 기재된 유전자로 이루어진 군에서 선택된 1종 이상의 유전자 발현의 변화를 분석하는 단계;를 포함하는 ADHD 치료 약물을 스크리닝하는 방법을 제공한다. 후보 약물의 투여시, 서열번호 1 내지 47에 기재된 하나 이상의 바이오마커 유전자들의 발현이 감소하거나/하고, 증가하거나/한 경우, 상기 후보 약물은 ADHD의 예방 또는 치료를 위한 약물로 결정될 수 있다.

상술한 본 발명의 내용은 상호 모순되지 않는 한, 서로 동일하게 적용되며, 당해 기술분야의 통상의 기술자가 적절한 변경을 가해 실시하는 것 또한 본 발명의 범주에 포함된다.

이하 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.

도 1에 나타낸 것과 같은 실험 스케줄로 SHR 랫트, WKY 랫트, 위스타 랫트에 약물을 처리하고 중추신경계 흥분성 동물 모델에서 행동 특성 및 유전자 발현 분석을 수행하였다.

보다 구체적으로 다음과 같다.

실시예 1.

1.1 중추신경계흥분제 의존성 동물 모델의 제작 및 평가

ADHD와 관련된 과잉행동, 집중력 또는 주의력 결핍, 충동행동과 관련된 인자들을 도출하기 위하여, 중추신경계흥분제 의존성 모델로 6주령의 SHR 랫트, WKY 랫트, 위스타 랫트 모두를 사용(한림실험동물)하여 실험을 수행하였다.

상기 중추신경계흥분제 의존성 모델에 대표적인 암페타민(amphetamine) 1, 2 mg/kg, 아토목세틴(atomoxetine) 3 mg/kg, 메틸페니데이트(methylphenidate) 2 mg/kg을 1일 2회, 7일간 복강 내로 투여하였다.

약물 투여 후, 다음의 방법으로 과잉행동, 집중력 또는 주의력결핍 및 충동행동을 평가하였다.

① 과잉행동 평가: 일반 운동 활성 시험

ADHD의 대표적 증상 중 하나인 과잉행동을 평가하기 위하여 일반 운동 활성시험(open field test) (Choi et al., 2008, Choi et al., 2008, Biomolecules & Therapeutics 16(2), 118-125)을 수행하였다.

EthoVision system(Noldus IT b.v., : 행동 관찰 장치) 및 그 프로그램 셋트를 이용하여 실험을 수행하였으며, 해당 장치에서 10분간 1회 이상 랫트를 적응시켰다. 시험 물질을 투여하고 30분 후 시험 박스 중앙에 실험동물 놓고 10분간 행동 양상 관찰 및 분석하였다. 총 이동 거리 (Total movement distance)를 측정하였고, 그 결과를 도 2에 나타내었다.

도 2에 나타낸 바와 같이, WKY 나 위스타 랫트와 비교하여 SHR 랫트에서 운동 거리가 증가되어 있는 과잉행동성이 뚜렷하게 관찰되었다. 또한 이에 아토목세틴을 처리한 경우 증가된 과잉행동성이 감소하는 것을 확인하였다. 따라서 과잉행동 증상은 SHR 랫트에서 확인되는 증상이며, 이러한 과잉행동이 아토목세틴에 의하여 완화될 수 있다는 것을 알 수 있다.

② 주의력 및 집중력 측정 (Y- maze test )

약물 처리된 랫트에서 공간 지각력 및 비 특이적 집중력 검색을 수행하기 위하여 Y-maze 테스트를 수행하였다. Y-maze 테스트는 실험동물의 집중력과 주의력 결핍을 평가할 수 있는 것으로 알려져 있다.

이 테스트에 사용된 장치는 3개의 가지로 구성되어 있다. 각 가지(arm)는 길이 42 cm, 넓이 3 cm, 높이 12 cm이고 세 팔이 접하는 각도는 120°이며, 모든 실험 장치는 검정색의 폴리비닐 플라스틱으로 구성되어 있다. 각 가지를 A, B, C로 정한 후 한쪽 가지에 랫트를 조심스럽게 놓고 8분 동안 자유롭게 움직이게 한 다음 랫트가 들어간 가지를 기록하였으며, 세 개의 다른 가지에 차례로 들어간 경우 1점 (실제 변경, actual alternation)씩을 부여하여 다음 공식으로 그 변경 행동력을 계산하여 집중 정도를 평가하였다.

[식]

변경 행동력(alternation)% = (변경의 수)x100/ (총 가지 진입-2)(total arm entries-2)

그 결과를 도 3 내지 도 5 에 나타내었다.

도 3 내지 도 5 에 나타낸 바와 같이, 주의력 및 집중력 결핍은 SHR과 WKY 랫트에서는 높게 나타났으나 위스타 랫트에서는 뚜렷하게 나타나지 않았다. 또한 SHR과 WKY 랫트에서 확인할 수 있는 이러한 주의력 및 집중력 결핍은 각각 약물 처리에 의하여 개선되었는데 구체적으로 SHR 랫트에서는 암페타민, 아토목세틴, 메틸페니데이트를 처리한 모든 실험군에서 개선되었으며, WKY 랫트에서는 아토목세틴을 처리하였을 때에는 유의성있는 결과가 얻어지지 않았으며 암페타민 및 메틸페니데이트를 처리한 실험군에서만 뚜렷한 개선이 확인되었다.

③ 충동성 평가

욕구 발현시 자제력 부족과 충동적 행위에 대한 평가를 수행하였으며, 평가 방법을 도 6에 나타내었다. 보다 구체적으로, 랫트에 식이를 제한하여 배고픈 상태를 조성한 후 두 개의 다른 레버를 누르는 방식에 따라 펠렛이 떨어지도록 설계된 관찰 상자에서 실험 동물들을 5일간 훈련시켰다. 이러한 충동성 평가는 먹이 즉, 식욕에 대한 충동성이 강한 동물은 훈련된 바에 상관없이 마구잡이로 레바를 누름으로써 레바 누름대비 먹이 취득효과가 현저히 떨어지고, 레바를 더 자주 더 많이 누르게 된다는 행동특성에 기초하여 이루어졌다. 따라서 large reinforcer를 선택하는 비율이 높을수록 충동성은 감소하는 것으로 해석된다. 암페타민은 1 또는 2mg/kg을 처리하였으며, 아토목세틴 및 메틸페니데이트는 각각 3mg/kg, 2mg/kg 투여하였다. 약물은 단기 및 장기 투여를 하였으며, 이에 따른 개선효과도 비교하였다.

충동성 평가 결과를 도 7 내지 도 9 에 나타내었다.

도 7 내지 도 9에 나타낸 바와 같이, 충동 행동 특성은 SHR 랫트와 위스타 랫트에서는 높게 나타났으나, WKY에서는 나타나지 않았다. 이와 같은 충동 행동 특성은 약물 처리에 의하여 개선되었는데, SHR 랫트의 경우 암페타민, 아토목세틴, 메틸페니데이트 모든 약물 처리군에서 유의성있는 개선이 확인되었으나, 위스타 랫트의 경우 아토목세틴 처리군에서만 유의성이 있는 개선이 확인되었다. 이와 같은 개선효과는 단기투여보다 장기 투여시 더 뚜렷하게 관찰되었다.

상기와 같이 확인된 각 실험동물의 충동성, 주의력 및 집중력, 과잉행동 특성과 약물에 따른 행동변화를 하기 표 1에 정리하여 나타내었다.

[표 1]

실시예 2

ADHD 질환의 증상인 과잉행동, 집중력 및 주의력 결핍, 충동행동과 관련된 유전자 마커를 확인하기 위하여 마이크로어레이 실험을 수행하였다.

2.1 RNA 분리

상기 실시예에서 제작한 동물모델 중 암페타민(1, 2mg/kg), 아토목세틴(3 mg/kg), 메틸페니데이트 (2 mg/kg)를 투여하여 행동학적 의존 현상이 확인된 랫트로부터 전두엽피질 및 선조체를 적출하였다. 적출한 조직의 전체 RNA를 Trizol 시약(Invitrogen, Carlsbad, CA, USA)을 이용하여 분리하였다. Trizol을 이용하여 분리한 조직 전체의 RNA는 Qiagen RNeasy Kit (Qiagen, Valencia, CA, USA)를 사용하여, 정제도를 높인 후, 260 nm 흡광도를 측정하는 방법을 통해 RNA 농도를 결정하였다. Agilent Bioanalyzer 2100(Agilent Technologies, Santa Clara, CA, USA) 기기를 이용하여 RNA의 품질을 평가한 후, 이를 통과한 RNA에 대해 마이크로어레이 분석을 수행하였다.

2.2 전두엽 피질의 전사체 발현 프로파일 분석

전두엽피질의 전사체 발현 분석을 위해 실시예 2.1에서 정제한 전체 RNA를 Affymetrix에서 인증한 마이크로어레이 CRO에 실험을 의뢰하여 원본데이터(raw data)를 확보하였다. 간략히 설명하면, 분리 정제된 5 μg의 RNA를 역전사고중합효소를 이용한 상보적 DNA (cDNA) 합성과 합성된 cDNA를 기반으로 한 비오티닐화(biotinylated) cRNA 합성 후, 분절화한 cRNA를 Affymetrix GeneChip Rat Genome 230 2.0 Array를 사용하여 분석하였다. 원본데이터는 Affymetrix의 Expression Console 프로그램을 사용하여 정규화하였으며, 유전자 발현 수준을 결정하였다.

2.3 마이크로어레이 정규화와 결과 추출

GeneChip 스캔을 통한 이미지 파일의 분석 및 정규화 과정의 품질 평가를 다음과 같이 수행하였다. 스캐너로 읽은 이미지 파일의 결점 존재 여부를 우선적으로 평가한 후, Affymetrix에서 제공하는 Expression Console 프로그램의 MAS5 알고리즘을 통해 읽은 기본값 분석 시 Scale Factor값이 3이하, 배경(background)값 20~100 범위, 5이하의 노이즈(noise)값, 내부표준(spike control)의 P call, 및 Affymetrix 보장감도 등을 평가하였다.

2.4 차별적으로 발현되는 유전자 ( DEG : Differentially Expressed Genes )의 결정

정규화된 마이크로어레이 데이터를 이용하여, Affymetrix Rat Expression Array 230 2.0에 존재하는 발현값 분포의 중간값(median value)이상의 값을 가진 유전자만을 선택하였다. 그리고 개별 probe set에 대한 MAS5 알고리즘의 분석값이 "present"를 동시에 충족한 유전자를 중심으로 "DEGs(differentially expressed genes)"을 선정하였다. 이를 충족하는 프로브 셋트의 수는 평균 15000~16000개에 해당하며, 실험군과 대조군의 발현값 비율을 구한 후, 이 비율값들의 히스토그램으로 그렸을 경우, 각 실험군의 히스토그램이 정규분포의 모양에 근접하였다. 이 비율값 분포의 5% 수준, 즉, 실험군이 대조군에 비해 증가한 부분에서 2.5%, 감소한 부분에서 2.5%를 결정하였을 때의 비율값은 증가한 부분 1.6~1.8, 감소부분의 비율값은 0.55~0.61에 해당하였다. 최종적으로 실험군과 대조군의 유전자 발현값 비율을 기준으로 1.8 이상을 보이는 유전자를 증가한 DEG로, 0.5를 감소한 DEG로 선정하였다. 이러한 과정은 도 1에 도식화하였다.

이상의 실험에 대한 결과는 one-way ANOVA, Newman-Keul's test 및 t-test로 유의성을 검정하여 p<0.05인 경우에 유의성이 있다고 판정하였다.

2.5 특정 동물모델에서의 DEG 분석

SHR 랫트에서는 WKY와 위스타 랫트와 비교하여 과잉행동 특성이 나타나고 이러한 행동이 아토목세틴 투여에 의해 완화되었다. 또한 SHR 랫트와 WKY 랫트에서는 위스타와 비교하여 집중력 및 주의력 결핍이 뚜렷하게 나타나고 이러한 증상은 SHR 랫트의 경우 암페타민, 아토목세틴 및 메틸페니데이트 투여에 의해, WKY 랫트의 경우 암페타민과 메틸페니데이트 투여에 의해 개선되었다. 또한 충동행동은 SHR과 위스타 랫트에서는 높게 나타나지만 WKY 랫트에서는 나타나지 않는 특성이 있었고, 이러한 충동성은 SHR 랫트에서는 세가지 처리 약물 모두가, 위스타에서는 아토목세틴 투여에 의하여 개선되었다. 따라서 이러한 동물모델 별로 나타나는 유전자 발현의 비교와 약물 처리에 따른 증상과 유전자 발현 변화를 비교하여 각 증상과 관련된 유전자 마커를 도출하였으며 그 결과는 다음과 같다.

[표 2]

대조 SHR v.s. 대조 WKY, 위스타에서의 DEG 수

[표 3]

대조 WKY v.s. 대조 위스타에서의 DEG 수

[표 4]

암페타민, 아토목세틴 및 메틸페니데이트로 만성적으로 처리된 SHR, 위스타 및 WKY의 전두엽피질에서의 DEG 수 (> 1.8 (상향), < 0.5 (하향))

상기와 같은 결과를 분석하여, WKY와 위스타 랫트와 비교했을 때 SHR에서 공통적으로 증가 또는 감소된 DEG로서 다음과 같은 유전자를 확인하였다.

[표 5]

또한 위스타 랫트와 비교하여 SHR과 WKY에서 공통적으로 증가 또는 감소된 DEG는 다음과 같다.

[표 6]

마지막으로 WKY 랫트와 비교하여 위스타 랫트와 SHR 랫트에서 공통적으로 증가 또는 감소된 DEG는 다음과 같다.

[표 7]

대조동물인 WKY 랫트 및 위스타 랫트와 비교하였을 때 SHR에서 특이적으로 발현이 상향 또는 하향 조정된 유전자 마커들 중 암페타민, 메틸페니데이트 또는 아토목세틴 처리에 의하여 증상이 변화되면서 동시에 그 발현이 반전된 DEG 는 다음과 같다.

[표 8]

2.6 결과

상기와 같은 DEG 발현 분석을 통해, ADHD 주요 증상과 연관있는 유전자들을 하기와 같이 분류하였다.

2.6.1 과잉행동과 관련된 유전자

과잉행동이 SHR에선 높게 나타나지만 WKY와 위스타에서는 나타나지 않는 특성과 약물에 의해 과잉행동이 감소되는 반응에 기초하여 분석하였을 때 과잉행동과 연관된 것으로 판단되는 유전자

[표 9]

2.6.2 집중력 및 주의력 결핍과 관련된 유전자

[표 10]

집중력 및 주의력결핍이 SHR과 WKY에선 높게 나타나지만 위스타 랫트에서는 나타나지 않는 특성과 약물에 의해 집중력 및 주의력결핍이 개선되는 반응에 기초하여 분석하였을 때, 집중력 및 주의력결핍과 연관된 것으로 판단되는 유전자

2.6.3 충동행동과 관련된 유전자

[표 11]

충동행동이 SHR과 위스타 랫트에서는 높게 나타나지만 WKY에선 나타나지 않는 특성과 약물에 의해 충동행동이 완화되는 반응에 기초하여 분석하였을 때 충동행동과 연관된 것으로 판단되는 유전자

2.6.4 ADHD 의 주요 증상과 관련하여 모두 유의성 있는 증가를 보이는 DEGs

상기와 같이 도출된 유전자들중 ADHD의 주요 증상인 과잉행동, 집중력 또는 주의력 결핍, 충동행동 모두와 관련하여 유의성 있는 증가 또는 감소를 보이는 DEG들을 분석하면 다음과 같다.

[표 12]

전전뇌 피질에서 ADHD 주요 증상인 과잉행동, 집중력 또는 주의력 결핍 및 충동행동과 관련하여 모두 유의성 있는 증가를 보이는 DEG들

[표 13]

전전뇌 피질에서 ADHD 주요 증상인 과잉행동, 집중력 또는 주의력 결핍 및 충동행동과 관련하여 모두 유의성 있는 감소를 보이는 DEG들

상기와 같이 표 12 및 표 13에 기재된 DEG 들은 ADHD 와 관련하여 공통적으로 유의미한 결과를 나타내므로, ADHD 발현 확인을 위한 훌륭한 지표가 될 수 있으며, 바이오 마커로 사용할 수 있음을 확인하였다.

<110> Sahmyook University Industry-Academic Cooperation Foundation <120> Biomarkers for detection of ADHD <130> P14-041-SYU <160> 47 <170> KopatentIn 2.0 <210> 1 <211> 6807 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(6807) <223> Atxn7 <400> 1 ggcgggcggg cggccggcgg cggctcggcc cgcggacccc gccgtctcgc ccggcccctg 60 cccacaggcc gccctggagg ccgcggccag ccgccagaat taagaaagga agtacttgtg 120 cccctgcaga tgaagatcca ctggtaagcc gatcgggagt cctggcctgc accccaaagc 180 aaaggagcgg aaagaatgtc ggagcgggcc gcggatgacg tcagggggga gccgcgccgc 240 gcggcgggcg gagcagcggc cgcccggcag cagcagcagc cacagcctct gcagctccag 300 cggcagcacc cgccgccgcg gcgcccacgg ccggaggacg gcggcaccgg ggccgccact 360 acctcggccg ccgccatggc gacggtgggg gagcgcaggc ccctgcccag tcccgaagcg 420 atgctgggac agtcgtggaa tctgtgggtg gaagcttcca aacttcctgg gaaggatggg 480 accgaattgg atgaaagttt caaggagttt gggaaaaacc gcgaagtcat ggggctctgt 540 cgggaagata tgccgatctt tggtctctgt cccgcacatg atgatttcta cctggtggtg 600 tgtaacgact gcaaccaagt tgtcaaacca caggcatttc agtctcactg tgagagaaga 660 catagctcat ctagcaagcc tcccttggct gttcctcgca cttcagtatt ttcgctcttc 720 ccatctctgt ccaaaagcaa agccggtggt gccggtggta gcagccggcc tcctggtgga 780 ggggtcctgt gcgcatcctc aagctccaag ttactcagat tgcccaaaga gaaacttcag 840 ctcagggcga acatgaagcc catgcatccc atgcagcaga ctaaagtccc ccatggaaga 900 gtcatgacac cctctgtgaa ggtggaaaag atgcacccga agatggacgg cgcactactg 960 aggtccacag tagggccagc ctgtcccgct cctgtgagct ctgcagtcaa gcctggcctt 1020 agctgtccct ccataccaaa gccaaccttg ccttcacctg gacagactct gaatggcaaa 1080 gggcttcctg caatgcccac tctggaaaag aaacctgaag acagttctaa taacaggaag 1140 tttttaaata agagattatc agaaagagag tttgatcctg acatccactg tggggtcatt 1200 gatctggaca ccaagaagcc ctgcaccagg tctttgactt gcaagacaca ttccttaacc 1260 cagcggagag ctgttcaggg cagaagaaaa cgatttgatg tgttattagc cgagcacaaa 1320 aacagaacca gggagaagga gctgattcgc catcccgact gtcagcaact accacaccca 1380 ctcagggacc cgcatcctac ccctcctagg actctgccgg agccacacct tcctgcagag 1440 tcaaagcctt ccttagcaag taaaccgaaa cctcacaccc ctagtcttcc aaggccccca 1500 ggctgccctg ctcagcaagg agggagtacc cctgtcgacc ctcctccagg ccgtgagtct 1560 ccacacccac ccttgcctgc cactgagcca gcttctcgct tatccagtga ggagggtgaa 1620 ggcgatgaca gagaagagcc tgttgagaaa ctggactgtc actattcagg tcgtcaccct 1680 cagccagcat cgttttgcac atttgggagc cggcagatcg gaagaggtta ttacgtgttt 1740 gactccaggt ggaaccggct tcgctgtgcc ctcaacctca tggtggagaa gcatctgaac 1800 gcacagctat ggaagaaaat cccaccggtc ccctgttcca catcacctgt ttctgctcgc 1860 gttcctcacc ggacgaattc tgtgccgaca ccacaaggtg gggtcagctc cttggcagca 1920 gccaccgtct ctgcacctgc agttgtgttg ccatcctcct gcgtctcccc aaatagcaag 1980 tcggcaccag ctcacggaac cactctaaat gcacagcctg ctgtttctgg ggcaatggat 2040 cctgtgtgca gtatgcaatc cagacatgta tctgcttcat cctcatcccc ctccacaccc 2100 tctggcctct cgtcagtccc ctcttctcct ctgtccagaa aacctcagaa attgaaacct 2160 agcaagtctg tacggcccaa ggagccttct gctgtcagca ctaactgtca cagtgccagc 2220 agcagtacca gtggtggctt agggaaaaaa cgcaaaaaca gctccccact gtcagttcat 2280 tcttcttcct cttcggcctc ctcctcctcc tcttcccatt ccgtggactt ttttaggaaa 2340 aactgtgtgg ctcactctgg gactccatac ctgtcaacag caccgtcttc ccacagtatc 2400 ggcctcaact gtgtgacaaa taaaacacac tctgtgagcc tccggcacga gccagtggga 2460 cggggtccgg ccggtgtgag ccctgcagag tccatcaaga ggatgagtgt aatggtgaac 2520 agtggcgact ccactctctc tcttggccca ttcgtccatc agtccagtga actgcctgtc 2580 agccctcact cacacactcc tctagacaaa ctcataggca agaaaagaaa gtgctccccg 2640 ggctctagca ccgttggcag cagtggcagc aaacctacaa aggtcgccag atcgccagcc 2700 atgaacagcg tccacatgaa gcacacaggc accatcccag ggccacaagg actgatgaac 2760 aattccctcc tccatcagcc aaaggcacga ccctgacagc tgacagtacc acgggaagga 2820 ataatccaga catttttgaa gacaagttac acctctgctc agcactctgg actccacgat 2880 gcctttgagt ctctttttct aaactcctgt ggaccttcag ggtaacctct ggctgtttga 2940 caaggatttt ccgaagttgt gtctgtagca gtgagtacac ataaaggaca ctggatcaag 3000 ttcagccacc agattgcttt ctcagtgtta aaagtggtct ggactacttg ctacccatct 3060 gtgagaagtt tttgtttgtg ttttgttttt gttttttttt tttttttact tggagcatat 3120 catggagcca ctcttgaagt agattggctg ggcaaagaat gttttggcaa gagtgtttct 3180 gtagactctc cctctttctc tgccagagtg tttttgaaca cattctcatc tgtaagtcag 3240 tctccagagg taggcacctt aactggagac tggaggcctt ccaaagaaag aggagcaagt 3300 tgcatcctga gtaacctcct agaggatatc tggctttaga gttttttaat agcagtgttc 3360 aggaatagaa atctaacgtt ggttaatgca ttatgacgta gtagcccagc ccttttcaag 3420 taatttggga taagaagctt atcaagttct tcagacttaa gaactggctt gaagctgctg 3480 atgcctggat attaagttaa agtatctcag aagcttagtt ttcatggtac aaaagcatgt 3540 gtgataaaaa gagagaaaga aagaggaaga atgaagaaaa gaaaaaatgg agagagagac 3600 aaggaaaact agtttggtga tgagaagcca attgggacac tggacaattg ggaggtaaac 3660 aattttcaag tgaggcataa tctgtagggt ttccaaagag actgacctct cttgtcactg 3720 ctcattttga accgtgtgtc aggttggggt tattgtctca ctcggcattg ctttttaaga 3780 tctgcctttt taaaagttac tataatgtcc ttaatttccc aggcatcact cccacttcca 3840 ctttgactgt tgtttggaga actaagtgta agtttctgct tccagtcctg ctgtcattgc 3900 gtctgcgtca ccgcttcctg tcagccttta gaggtgctta tttgaatgca ggtgggctta 3960 ggtggagacc ccccaagaaa gggtggttgg agagccttgt gtgcatgccg tggagagaag 4020 cagcttcgtg agggtacata ctgtgtgctc acgcacaccc gtctttctgt gacagtaata 4080 gccatcttcc ttcagtgagt tttaaagccc tcttcacgat ttctcagcac cccactccca 4140 aagaatgctc aatgtgttaa aacattgctt gaaaagacgt ctaccggaga atttggggat 4200 gaactagggc cactgtaaca gctcctgctc agaggactga gtcctcgggc ttaggaagag 4260 tacagcagca tggccaacag gacagccccc aaggctccta gtcctgtcct ggccagtgtc 4320 tgggcagagc gcagtcattg cgttctttcc ctacagttct tagattacaa acttgaggtt 4380 cagggaactt cagtcaacaa cggggagaat gagtagtaaa tacttggtta ccagcctaat 4440 aatgtgaatt gctacattta ctcttattat gtaagaacac aaagacttta tgcagatact 4500 ttaactataa attaatggaa atgttgaatt tttttaagga agggaaaaca gaatcttatt 4560 cacttattat gcaatcagtc ggtgaatgtt ttaaagctca tgctcgagga gctctaggcg 4620 cagatgggcc agtgtggtaa agttaggagg tccatctgat tgtctgtcct agtgctgcgg 4680 aaggagcaga gggaaccctg gctcacggtc attacttgct gacaagtgca atggggtgtg 4740 gggtagattt attttcagaa ccggggactt gatggttata aattaagatg cttttagtgg 4800 ttgagtttct agacagatgc tgttccgaaa gatgtgaata ggagccacgg taggaagttt 4860 attcagagta aagtagatag tacttaggtt aatgagcgct atagcttgat ccttagactt 4920 cattatatct ccaggaaaca cacagagcct cgggattagg aaaagccatt ttggattctg 4980 cctgccacaa acacatgttc taaacagtgc actaaagctt agactgttca aatactttta 5040 ttttctctga caacgacgtt ttatgatggt gaacaattaa gaccatttaa aataagggag 5100 tataatattt ttgaattagg ttaacttgca gaaccagatt tgcagtgctt ggcttgattc 5160 taggtagact ttggtatcaa tttaaaacca ggatactttt ttatattctt tccaatagaa 5220 ttcatgacag cttctgcagt tttcttaaac tacaaagaaa taaaagtgct gcaatgatga 5280 acaaagaatt ataaaaacct acttttgtat ctttattttg gaatttcttg tctattataa 5340 atatggaagt gccctatttc agaagacata ttttgttaaa aatgaattgt acatatttaa 5400 atatgtattt ttgcacaggt ctttttttct gatatcctgt ttttggtaca attgagatca 5460 tctagtattt atttattaat taataaaaat aaataccttt ttataatttg aagtggttca 5520 ctgccaagcc agtagtttag aacctgcctc ctgtacagtt acgggatgcc tctgctgtgt 5580 gggagttgtg tccattttag tgtctccggg gtgggtgcaa gcagatgaag tgggcacggc 5640 atctctcagt tgcctgattt ccgaatagac tacatggagc aaagtgacac actgcttttc 5700 tttgtttagt tttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 5760 agagagagag agagagagag agagagagag agagagagag agagcatgcc gctctgagca 5820 cacctgtgtt attagtatgt gatgtggttt aaaactaatg aggaaacaaa acaaaacaaa 5880 actgaaagtg cctgaacctg gtttaagctc agacagatat ctttaaagac ttgaatgctg 5940 agttgaactt ctggagtttg ctttttccac ctaaatatta tttcttaaag tttaagggga 6000 gaagttaaaa gccagcaagg ctggtaattt ttataaggta ttttaaatta agaccttttt 6060 ggttcacagc aatttcactg cagtggactg cccagtgcca ccaagggtta taaactgttg 6120 tcactcatgt aatacagagt ttaagatagg atatttaaaa tattttgtat taaaaaatac 6180 aagaagtacc tcggagaaca ttgaaaaatg tttaatttga aaaaaaatat gtaccttata 6240 aaggcagctg tcttcctgta agagttctgt tgccaaggga tttcttaatg tctccattct 6300 gtcctgggtt ggggaaaagt taggctttga aaaatgattg ttaaaagttt cactgtttaa 6360 aagagagtaa tcatttttac atcttaatgt aagacatttt accttttcag atcacttaaa 6420 tgagcactac atactgtcag tgtgaatgca gggccttgaa agaatttttt tttttttgag 6480 cttggttatt aaagcaatct cctgtgttaa aatgtgtgaa tagtttgata catgtgtacc 6540 cataatcaag agcatctcag ctggactttg tgttggctgc tgtatagaaa tgaacaaatg 6600 tcaagggata gaaaattact ttggatattt aaaagagaag aaatatatag tctatttgtt 6660 ttgtaacaag tttctgtaaa taaaataatt tatactattt ataagaaaag ttgtgttttg 6720 ctttatgaga aattagtttg ttgaacaaac attgttacta aacgggcaat aaaactagga 6780 cttttcaata aataaggttg gctgcac 6807 <210> 2 <211> 5761 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(5761) <223> Per2 <400> 2 ggctccgggc ggctgcggcg caggccgagc gcaccaagtg acgggtcgag caaaggaccg 60 acgcgcgggt ggacgctgcg aagcgcctca ttccagagcc cgacatgaat ggatatgtgg 120 acttttcccc aagtcccacc agccccaccc aagagccagg ggagcctcaa cccacccagg 180 ctgtgctcca ggaagacgtg gacatgagca gcggctccag cggaaatgaa aactgctcca 240 cggggcggga ctctcagggc agtgactgtg acgacagtgg aaaggagctg cggatgttag 300 tggaatcgtc caacactcac cccagccctg acgatacctt cagactcatg atgacagagg 360 cggagcataa cccctccaca agcggctgca gtagtgagca gtctgccaaa gctgacgcac 420 acaaagagct gataaggacc ctgagggagc tgaaggtcca cctccctgca gacaagaagg 480 ccaaggggaa ggccagcacg ctggcaacct tgaagtacgc tctgcggagc gtgaagcagg 540 tgaaggctaa tgaggagtac taccagctgc taatgtccag tgagagccag ccctgcagcg 600 tggatgtgcc ttcctacacc atggagcagg ttgagggcat tacctccgag tatattgtga 660 agaactcgga catgtttgct gtggctgtgt ccctggtctc tgggaagatc ctgtacatct 720 ccaaccaagt cgcccccatc tttcactgta agaaggacgc cttcagtgat gccaagtttg 780 tggagttcct ggctccccat gacgtcagtg tgttccacag ctacaccacc ccttacaagc 840 ttccgccctg gagtgtgagc agtggcttag attctttcac tcaggagtgc atggaggaga 900 aatctttttt ctgccgtgtc agtgttggga aacaccacga gaatgagatt cgctaccagc 960 ccttccgcat gacaccctac ctggtcaagg tgcaagagca gaagggcgct gcgagccagc 1020 tctgctgcct gctgctagca gagagggtac actcaggcta tgaagctcct agaattcctc 1080 ccgagaagag aattttcaca acaacccaca caccaaactg cctgttccag gatgtggacg 1140 aaagggcggt ccccctcctg ggctatctac ctcaggatct gatcgagacc cctgtgctcg 1200 tgcagctcca ccccagcgac cggcccttga tgctcgccat ccacaagaag atcctacagg 1260 ccagtgggca gcctttcgat tattctccca ttcgattccg cacacgcaac ggggagtaca 1320 tcacactgga cactagctgg tccagcttca tcaacccgtg gagcaggaag atatccttca 1380 tcatcgggag gcacaaagtc agggtaggcc ctttgaatga ggatgtgttc gcagcctccc 1440 cttgcccaga ggagaagact ccgcacccca gcgttcagga gctcacagag caaatccacc 1500 ggctactgat gcaacctgtc ccccacagcg gctccagtgg ctatgggagc ctgggcagta 1560 acggatccca cgaacacctc atgagccaga catcatccag cgacagcaat ggtcaagagg 1620 agtctcactg gaggagatcc ggaattttta aaaccagtgg caagagtcaa agcaaaagtc 1680 acttttctcc tgagtctgga ggacaaaagg aagcctctgt tgcagaaatg caaagtagtc 1740 ctccagctca ggtgaggtct gtcaccacca tggaaaggga cagctcgggg gccagcctac 1800 ccaaggctag ctttccagag gaactaacct ataagagcca gcctccttgc tcctaccagc 1860 agatcagctg cctggacagt gtcatcaggt acctggagag ctgcaacgag gcagccaccc 1920 tgaaaagaaa gtgcgagttc ccagccaaca tcccatcccg gaaggccacg gtcagccctg 1980 ggctgcactc tggagaggca gcgcggtcct ccaaggtgac cagccacacg gaggtcagtg 2040 ctcacttgag ctccttggcg ttgccgggca aggccgagag tgtggtgtcc ctcaccagcc 2100 agtgcagcta cagcagcacc atcgtgcacg tgggcgacaa aaagccacag cctgaactag 2160 agacagtaga agatgtggcc agtgggcctg agtcccagga tgatgcagct ggtggcctca 2220 gccaagaaaa ggggtctctg cagaagctag gcctcaccaa ggaagttctg gctgcacata 2280 cccagagaga ggaacagggc ttcctgcaga ggttcaggga agtgagcagg ctcggtgccc 2340 tgcaggctca ctgccagaac tatctccagg agcggtcccg agccccagca agtgatcgag 2400 gactaagaaa tgcttctgga atagaatcat cttggaaaaa aactggaaag aacaggaaac 2460 tgaagtccaa gcgtgtcaag actcgagact cttctgagag cacagggtct gggggacccg 2520 tgtcccaccg acctcccctc gtgggcctga atgccacagc ctggtcgccc tctgacacat 2580 cccagtctag ctgtccctct gcaccattcc ctgctccagt gccagcttac ccactacctg 2640 tgttcccggc acctggaata gtatccacac cagggacggt ggtggcacca cctgcagccg 2700 cccacaccgg cttcaccatg cctgttgtgc ctatgggcac ccagcctgaa ttcgcagtgc 2760 agcccctgcc gttcgctgcc cccttggctc cggtcatggc cttcatgcta cccagctacc 2820 cgtttccacc agcaacccca aacctgcctc aggccttctt ccccagccag cctcactttc 2880 cggcccatcc cacacttgcc tctgaaataa ctcctgcctc ccaggctgag ttccctagtc 2940 ggacctcgat gctcaggcag ccatgtgctt gcccagtcac ccccccggct ggcacagtgg 3000 ccttgggcag agcctccccg ccactcttcc agtcccgagg cagcagtccc ctacagctta 3060 acctgcttca gctagaggaa gcacctgaaa gtagtactgg agctgcaggg accttgggga 3120 ccacggggac agcagcttct ggtctggact gcacatctgg cgcatctcgg gaccggcagc 3180 caaaggcacc tccaacatgc agtgagccct cagacaccca gaacagtgat gccatctcca 3240 cctccagtga cctgctcaac ctcctcctgg gcgaggacct ctgctcagcc accggctcag 3300 cactgtcgag aagcggggca tctgccacct cagactcact gggctccagc tccctgggct 3360 gtgacacatc ccggagtggg gcaggcagca gtgatacaag tcacaccagc aaatactttg 3420 gaagcattga ctcttcagag aataatcaca aagcaaaaat gatcacagac acggaggaga 3480 gtgaacagtt cattaagtac gtcttgcagg accccatctg gctgctgatg gccaacacag 3540 acgacaatat catgatgaca taccagctgc cctcccggga tctccaggcg gtcttgaaag 3600 aggaccagga gaagctgaag ctgctgcaga ggtcccagcc ccacttcacg gagggccaga 3660 ggcgagagct tcgagaggtt catccgtggg tccacaccgg gggtctgcct accgccatcg 3720 acgtaacagg gtgtgtttac tgtgaaagtg aggagaaagg caacctttgt ctgccatatg 3780 aggaagacag tccttccctg ggactctgtg atacctcaga agccaaagag gaggagagcg 3840 gacagctggc caatcctagg aaggaggccc agacgtaacc ccgtccccgg ctagaagtct 3900 acattagacg gtgctcggaa gaggtggaag agcttgtgtt tctaacgaaa tggacccata 3960 ccttcactgc ttcttttgtt ttagaaaaaa aaaacaaaac accatagttt tctgaaggtg 4020 gaacagagct gtggggaggt ttaggaggaa atacgttttt gtattaaaat agaaatatgg 4080 aatttggggg atggggtgag attcgtcatt ggacttgagg agactgagac catctgtgtg 4140 tcatctggag gtcagaagtc cctgacctcc atgagacctc tttccagtgt accagtgtcc 4200 tcttacccct ggggattgtc ctgaaacatc aggatgtttc agatcaccag gatgtgacat 4260 ataacgggga agccacatga ggctcagcca agggcctgct ttctggaact ttcccatggt 4320 gtggttgtat cagatcctat ctcccaagca gagagaccac ccctcctgac atcctctcag 4380 tgcgttccct tatgtggttt ggagcatggt gtggcagctt ttgcttcagg tcctgtggtg 4440 gccagcattc cagtcggacc tggcttcagt tcatcaacag agttgaaatg cctactctgg 4500 actgatggag cttagtggtg tctgtgaccg atgccatcag actagcaccc acactgtacg 4560 tttctgtgcc gttcttggat cctttttaga ccatcatggc cagtgtgcag agagagctgt 4620 ggcttcagcc atgtcaccct gtctgtttgg tggcctctgc aagccaagct ttgttgctgc 4680 tggggacgcg gtcatatatt tgttctttgg ttggactctc agatttcagc ttccagcaga 4740 aagcagccac tgaacatggg gagagggcac ccacactgtc accctgagct cttcagtttg 4800 cagggagctc agcctcccac tatatatata tatatattcc tagctcctgt ggctttggtt 4860 ctctgtcaca tctgtctgtg ctgctggtcc tcagaccacc ggaacccatg gagagaaggg 4920 gacctctctg cccagctcta caaaacctta tgctgcatca gacatccaaa gattgttccg 4980 acatgcttcc tggtgacccc tggtggaatg agacatcacc agtgaggaac tgttagactt 5040 aaaacatgga caaagtctgg agcagaggaa gcagactttc ctgagtctaa agcggctact 5100 agaaaggtgt tcctactata gctggttttc atgggaaagc catctgatgc ctgaatatca 5160 cccctatttt tcataaagat aagaaatcta tttttattat tattattatt aaagcaacac 5220 cacctttcac aatgatcagg tagtagccat gttttaaagg aaattcaatg ttacagacag 5280 ctgcctctga ccagtcagag cctaagagta gatagatggt ggtctaagcc tacgcttgtt 5340 acttaaacac aaaactgcca aaaccttctc tctactatct tgaatgttta ccatcagcat 5400 tattttatga ttatttaata tatattcctt gattgttaac tgctaagaag ttgacttcct 5460 aggataattt tgtgaatctg tttacaagat gccaagcatc cagtcctgtt ttctttagaa 5520 tgtgtgctta cacgggtgtc ctgagacttt ctctatttga aactgagcct tctttgtaat 5580 gtaaataagc tctcagagtt tgtgcgatga tttgtgagcc ttgccggaca agcggtttgt 5640 tcatgcgcaa accaaacgta ccttcaccca gtgcaatata tttgtgtgac tgcttgtgtc 5700 tttttatgac ttttttgcct tttagaaaat tgttaaataa agcaagtata tttttatttt 5760 c 5761 <210> 3 <211> 2650 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2650) <223> Ogn <400> 3 tcagcagttt gaagcaattc cacagctttg ctcattcact ctcccacttg ggactaatgc 60 acaggaaaac tcagggactt caaccagata ctacgggaaa aaagaggttt gttccacagt 120 catcaggtca gtaatttcct aacttctagt caccttgtgt ttgctgcaat gaagactgtg 180 catcctacgc ttctcctgct attgttcgtg cctctgacac agcaaacacc acaaactcag 240 ctggactcac acgttaactc taagtatgga acagataatt ctgaagaaac caaatttatc 300 caggattatg aagataaata cctggatggg aaaaatatta aggaaaaaga aactatgata 360 attcctgatg agaaaagtct tcagttacaa aaagatgaag tcataccatc agtgcccacc 420 aagaaagaaa atgatgaaat gcccacatgc ctgttgtgtg tctgtttaag tggctctgtc 480 tactgtgaag aagttgacat tgatgctgta ccaccactgc caaaagaatc agcttatctt 540 tatgcacgat tcaacaaaat taaaaagctg actgccaagg attttgcaga catgcctaac 600 ttaagaagac ttgattttac gggaaatttg atagaagaca tagaagatgg tactttttca 660 aaactttctc tgttagaaga acttacactt gctgaaaacc aactactaag acttccagtt 720 cttcctccaa agcttacttt actcaatgcc aaatacaaca aaatcaagag taaaggaatt 780 aaagcaaaca cattcaaaaa actgaataaa ctctcttttc tctatttgga ccataatgat 840 ctggaatctg tgcctcctaa tttaccagaa agtctacgtg taattcacct tcagtttaac 900 agcatatctt caattaccga tgatacattc tgcaaggcta atgacactcg gtacattcgg 960 gagcgcatgg aagagatccg cctggagggc aatccgattg ctctgggaaa gcatccaaac 1020 agctttatct gcttaaaaag attacccaca gggtcatact tttaaccttc atcagtgcat 1080 ttataatctg aggtacatgc acctgatgtc taaaggaaca tacacattag tttaacatta 1140 tcgttttatc tcactatgat ggaatcttat gttttaacaa agatgtccaa atttctgaaa 1200 tgtaattata aaaataatcc agcctgaatc tcctagttca aaacaaagta acgtgaacat 1260 aaacagcatt agaaacctcc gtggttgtag cagaccgcca tctaaacagt gcgcttttac 1320 acaaacactc gctcacacac accattgcca tgactaatga agtcagagaa ttccaaaaaa 1380 actctcaact ttgtcttcct taacatttac tgtgtctcaa aggcatttaa gacagatgct 1440 ccagaacctg tgcacagcca agtgctccca gtgaccttcc cctgactcta tgactcaccg 1500 gtgttctctg taaagcagaa acttactttc tgtccaggca gctacttcac tgtatttctc 1560 acttagccta aggaaagggg agccacatgt aggcaatcat ttccagagga agtaaaattt 1620 tgctctttgg tacagagcca acttagcaaa gttcaatctc ctgctttgtg gtcacgtgca 1680 tagtctttag tcaattactt aaaaaaaact ttgtcagaaa aaaagtaaaa ttcctaccca 1740 tttctcaaag aataaggttc cttcgcttta aagattctta ttccaatttt agtgtatgtg 1800 ttgcgaaagc aagcacaaag attctgaaat atgaaattag ctatacactt tctcacagta 1860 tatttattca aatataagaa atgaaaacaa aataccccat tatgctgtgt gcagtttcac 1920 ctgtacatac atgttcacct gaacaaactg aatattccca ttctagccca agagtaccat 1980 ttctcactgg ccaagatctc tacatatatg taatagtgaa aacccagtct ccagtctgat 2040 agtgagagcg atgcacacta aggttccaaa cggaactgca gaggaagggc atagcccact 2100 cacaaatatt actttattac tttggtgatg aatacaaaat gatcagtgtc ttagaaatta 2160 ttcatctttt atatataaaa gtaccaatat catttccact ataagctata catcagactc 2220 tacatgttca tcctagaaca tccattttaa gcatttggtt gttttgtttc aacccagact 2280 gaccattctc tcatctgtta gggttaaccc cagatgaaac ttttcatcat taaagcatct 2340 gtgatctata aggccacaac tattgctcta ataatgtcta ctagtttatt tgtttttata 2400 agttaattat agtaacttta tctctctgta tcattttgtt cgcaggcctc attttctctg 2460 actgaatgct caccaagagc actgaacaca gttctacttt tatgatactt aataccatat 2520 ttcagctaaa tatacaataa acactgtaaa atctatccaa atagaagggt tctgtttata 2580 tggaaaaaac aaattagtat agtcttgaat aaatcaacag aaataaagtg acaagtttaa 2640 gaacggtcaa 2650 <210> 4 <211> 2010 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2010) <223> Pbld <400> 4 gatgaagctc ccgattttca tagcagatgc gttcacagtg acagctttcc acggtaatcc 60 tgccgcagtc tgcctgctgg agagcatact ccaggaagac gcccatcagc aaattgcgag 120 ggaaatgaac ctctcagaaa cggctttcat ccggaaactg cagccgacgg acagcttctc 180 acaaagttct tgctttggac taaggtggtt tacgccagtg agtgaagtcc ccttgtgtgg 240 ccacgccacg atggcctctg cggctgtgct gtttcacaaa ataaagaacg tgaacagcac 300 cctgaccttt gtcactctga gcggggaact aaaggccaga agagcagaag acgggattgt 360 cctggacttt cctctctacc caaccttccc ccaggacttc catgaagtta aagacttgat 420 aaaggcagcc ataggtgaca ctacagtcca ggacatccag tattctccag atacccgaaa 480 actcctggtc cggctcagcg attcttatga caggtccttt ctagagagcc tgaaggtgaa 540 cacagagcct ctgcctggaa ttgagaagac aggaaaggtg aaaggcctca tcctcactgt 600 caaaggagag tctggggggc agacgacccc atatgacttc tactccagat actttgcgcc 660 ttgggttggt gtacctgaag acccggtaac aggatctgca cacaccgttc tcagcagtta 720 ctggtcccag cagctcggga agaaagagat gcgagccttt cagtgttcct gccgaggagg 780 ggagctggac atttccctgc gacctgatgg gcgggttgac atgaagggcg gagccgctgt 840 tgtcttggag ggcatgctga cagcctagag atgcttatgc tgggcttgca gctcaactct 900 tctctacagc caagaaccca acccaaccca accaaacagc accaagtggt gccctcagtc 960 ctctcgtgaa gaccagagaa gggaagacat ttgatggagg tgctgaatcc tctcctgatt 1020 ctccagaatc ctctcctggt ggtgggctcc gggctctgcc tgtgtatgca tcttcagtcc 1080 ctatagcaga cacggatgct gtcccttttt ttttttatga ctgccaaagc aagagatgca 1140 ttgataagga gccagatgaa gccatttcaa tcccagttgg gtaccttagg gtatttcaca 1200 gccttgtaga agaataaata gctgtgtaga cctgttgtgt tgccaagaac atttcctccc 1260 caccccctga ggttccaaag accaaccaag gtactatcac cacccaagtt cccctagggc 1320 acaaatgagt tatcgggctt ccttacagag catagttgaa gggttacctc catcagtgtg 1380 ggtgtgctcc cctgaaatgt ggcatgcaac agcaatgctg actttcctat agtggcacag 1440 atggagccct gctccccaaa tctctgctgg cccatgtcct cagcctcttg tgaggccatg 1500 tgcagttagg gcagagttgc atgccgcagg tggtagggag tggattctca gaggaggccg 1560 tatgctctcc ccattcctct atgaggagat gtaaatagtc accagccccc gctgcgatga 1620 tctttggcaa gatgtaggaa accatctccc gatgtaatca tactaagaaa gaaaggcaaa 1680 tagatcgaaa actgtcagag gctctgctcc aatgctgggg aatatgggtt tgtatgggct 1740 ctaaggacag caaaatgaaa cagttcatct tggaggacaa tggaatttat agcttaaaaa 1800 aatgagttgg gagcttgctg agtggctgaa acatttgatg tcaaggataa caacctgagt 1860 ttgaatcctg ggacccacac cactcctaca tgttgtcctg taacctatgt gctatagcat 1920 gcacacaccc atacatatac atgcataccc ccaaacaaat atatgtaata aaaatcatat 1980 tcttcaaaaa aaaaaaaaaa aaaaaaaaaa 2010 <210> 5 <211> 1379 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1379) <223> Pxmp4 <400> 5 tgcttggcca gctaggtcct tcgacccagt gctccggtgc tatggctgcc ccgccgcagc 60 tacgggctct tctccaggct gtcaacaagc tgctgcgcca gcgccgttac cacgctgcgc 120 tggccgtgat aaagggcttc cggaacgggg ctgtctatgg agtcaaaatc cgggcgcctc 180 atgcactggt gatgaccttt ctcttcagga gtggcagtct ccaagagaag ctgcaggcca 240 ttctgaaagc cacgtacacc cactctcgga acctggcctg cttcgtcttc acctataaga 300 gtctccaggc cctacagtcc catgtgcaag gtgggaccca ccagatgcac tctttcctgg 360 ctgccttcat cggggggctc ctgctgtttg gagagaacaa taacattaat agccagatca 420 acatgtacct gacatcacgt gtcctgtttg ccttgtgccg cctgggtgtg gagaagggct 480 acatccctgc gctcaagtgg gacccgttcc ccttacacac ggcggtgatt tgggggcttg 540 tgctgtggct ctttgagtat caccggccca ctctgcagcc ctcactacag tcctccatga 600 cctacctcta cgaggacagc aacgtgtggc acgacctctc agacttcctc atcttcaaca 660 agagccgccc ctccaagtaa cacagcccaa ggtgcttcgg gaactccaac gcccagacag 720 cttccaggca gcgtcccgct gctgctcagg gtaccgttct attggcatac cgtcatggag 780 gatcctgcct tctcaaagtc atggacctca cactccaact tttattatcc caggctccca 840 cttgctgaag gaaaagtacc gaggtttacg cctgcctccg gatactgtag caagtggctg 900 gatccagcta aggattccag atgctcttcc gacctctgta aggccagggc gagttcaacc 960 ctctctgggc ctcaggtcat tcagttcagg ggaggaccct cagaggagag tgtcctcctg 1020 ggggatacgg tgaccctccc ctctactgtg tatcagaggg ctccttgcta ctgggcaata 1080 ggttacaaat actttgaaag ggaaaaaaaa actaaattct ttgtctaagt tattctaccg 1140 agacgttccg gacggaaccc tactgtccaa tgggaacgaa acatgagcca ttcgatagag 1200 gtacagcacg tgccaggctt gtgcgagatc ctatcaccag cactgagaat aaaacgccta 1260 gtgaccacat ttctgagatg cattaagaag gctgtggcac tagggttatg agctccaggc 1320 caggctggga tacattaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1379 <210> 6 <211> 3196 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3196) <223> Vps52 <400> 6 cgttagctca actatctggg aaccttttgt tgctccgtag aagacgttcc aggacttgtg 60 gctttgcttc gggaaacgga ctctcagaga ctgacagctg ccggaagtga ggctgcgggg 120 gaatggcagc cgcggcgacc atggcggctg ctgcccggga gctggtgttg cgggccggcg 180 cttcagatat ggaggaggag gagggcccgc tgggggctgg ttctggactc caagagcccc 240 tacaactcgg ggagttggat atcacctctg atgaattcat cttggatgaa gtggatgttc 300 acatccaggc aaatctggaa gacgagttag tgaaggaagc tctcaaaacg ggtgtggatc 360 ttcgacacta ttcaaagcag gtggagctag agctgcagca gattgagcag aagtcaatcc 420 gggactacat ccaagagagt gaaaacatag cctctctgca caatcagatc acagcctgtg 480 atgccgtcct agagcgcatg gagcagatgc tgggagcttt tcagagcgac ctcagctcca 540 tcagctgtga gatccgcacc ctgcaggagc agtcgggggc catgaacatc cgacttcgta 600 accggcaggc agttcggggg aaacttgggg aactcgtcga tgggctagtg gtgccctctg 660 ctctggtcac agcaattctc gaagctccag tgacagagcc caggttcctg gagcagctcc 720 aggagctgga cgccaaggcg gctgcggtca gagagcagga ggcgagaggc acggccgcct 780 gtgcagacgt cagaggcgtg ctcgaccggc tccgggtcaa ggcggtgaca aagatccgtg 840 agttcattct ccagaagatt tactcgttcc gaaagccgat gaccaactat cagatccccc 900 agacggccct gctgaagtac aggtttttct atcagtttct gctgggcaac gagcgtgcta 960 cagccaagga ggtcagggat gagtacgtag agacgctgag caagatctac ctgtcatact 1020 accgctcgta cgtggggcgg ctcatgaaag tgcagtacga ggaagttgct gagaaagacg 1080 atctaatggg tgtagaagac acagcaaaga aaggattctt ctcgaagccg tccctgcgaa 1140 gcaggaacac catctttacc ctgggcaccc gtggtgctgt catctcaccg gccgagctcg 1200 aggcccccat cctggtgccc catactgccc agcgtggaga gcagaggtac ccgtttgaag 1260 cactcttccg cagccagcac tatgccctcc ttgacaattc ttgccgtgaa tatctcttca 1320 tctgtgaatt tttcgtcgtc tctggcccgg ctgcccatga cctgttccac gccgtcatgg 1380 gccgcacgct gtccatgacg ctgaaacacc tggagtccta cctggccgac tgctacgacg 1440 ccattgctgt ttttctctgt atccacatcg ttctccggtt ccgcaacata gcagcaaaga 1500 gggacgtccc tgccctggac agatactggg agcaggtgct ggccctgctg tggcctcgat 1560 ttgagctcat cctggagatg aatgtgcaga gcgtccgcag cactgacccc cagcgcctcg 1620 gggggctgga cacccggccc cactatatca cacgccgcta cgccgagttc tcctccgcgc 1680 ttgtcagcat caaccagacc atccccaatg agcgcacgct gcagctgctg ggacagctac 1740 aggtggaggt ggagaacttt gtcctccgcg tggctgcgga gttctcctcc aggaaggagc 1800 agctcgtgtt tctgatcaac aactatgaca tgatgctggg tgtgctgatg gagcgggctg 1860 ctgacgacag caaagaggtg gagagtttcc agcagctgct caatgctcgg acacaggagt 1920 tcattgaaga gttgctgtca cccccctttg gaggtctggt ggcatttgtg aaggaggctg 1980 aagccttgat tgagcgtggg caggctgagc ggctccgagg ggaggaagcc cgagtcaccc 2040 agctgatccg cggctttggt agttcctgga aggcgtcagt ggagtccctg agtcaggatg 2100 taatgcggag ttttaccaac tttcgaaatg gaaccagcat catccagggg gcgctcacac 2160 agctgatcca gctctaccat cgcttccacc gtgtgctgtc ccagcctcag ctccgtgccc 2220 tccctgccag ggccgaactc atcaacatcc atcacctcat ggtggagctg aagaaacaca 2280 agccgaactt ctgattcaga ccccggggcc cgaagctccc atgggctctg cagtcacaca 2340 gtgtctgtca cctgggaccc ctttcctgtt cctgatgtct ctaaggcttt cacacacctc 2400 actcagcctc cattgccagg actctgcctc aacagagtgt gccctcggcc actccctggg 2460 cttctgaggt gaccttcata gcccagccca gccccctcct ctgctgttca ctcacagcct 2520 gtgagctctc accgccccag tccctgactg acactcggct ctcatggcag agcggtgcag 2580 gccacactgc ccacgctgca gctgatcttc aggctccact gggacagtgg catcagctcc 2640 cggcgggtgc actctgcctg tggcaataca gtacttactg tgctgggacg tgtcctcccc 2700 tgtgtccctg ggtccagcat ttctttattg tagacctagt cagttcctgg tgggctgcag 2760 caagggtggg gtagtagccc gaggactgtt ggtgcttctg gcccaggggt ggcatagtgg 2820 ctcaggtgag gactgttttt acctctccag gagggtggca cacgccacag gcctgggaag 2880 gtgagagctc tgtgcactgt cttgagggct gccatgggag aatccacaca gactctgaga 2940 ttgtctgtgt tgtcctctaa gtggctgtca cagctccttt gagagtggag ggcctgtaat 3000 acctgcaccc atgtgtcgag gcaggggtgg acctagtccc aaaacagacc ttgtcatgtc 3060 catgtgaccc agacccttcc cactgccctc tgccccacct ctgtatggag tttccagagc 3120 agtggttctc aaccttcctg agactcttta atacagttct tcatggtaaa aaaaaaaaaa 3180 aaaaaaaaaa aaaaaa 3196 <210> 7 <211> 5210 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(5210) <223> Slit3 <400> 7 cccagaccga atcctcacct ctgccggcca cccacaggga cccgagagcg ctccgtacct 60 gggcaccgtg agtgatgcgc agcggggcag cgccagcccc acggatggag ctgctgccgc 120 cgccgcccgg cgcgccccgc tccgcccgcg ccccgtgcgc ctgagcgccg cgcccgcccc 180 tcctccgcgc caactccgcc gcccgccccc caggccgccc gcgcgcctcc tcgggctcct 240 cgtgtcccgc cgcgccaagc agcctcctct gggtgctggc gcctgtacac catggccccc 300 gggcggaccg gggccggcgc cgctgtgcgc gcccgcctgg cgctggcctt ggcgctggcg 360 agcatcctga gcggaccccc cgctgctgcc tgccccacca agtgtacctg ctccgccgct 420 agcgtggact gccacgggct gggcctgcgc gccgttcccc ggggcatccc ccgcaacgct 480 gagcgccttg acctggacag aaataacatc accaggatca ccaaaatgga cttcaccggc 540 ttgaagaatc tccgagtctt gcatctggaa gacaatcagg tcagcgtcat cgagagaggc 600 gccttccagg atctgaagca gctggagcga ttacgtctga acaagaacaa gctccaggtc 660 cttccagaat tacttttcca gagcacaccg aagctcacca gactagatct gagcgaaaac 720 cagatccagg gcatcccgag gaaggcgttc aggggcgtca cgggcgtgaa gaacctgcaa 780 ctggacaata accacatcag ctgcattgaa gatggagcct tccgagcgct gcgcgatttg 840 gagatcctca cccttaacaa caacaacatc agccgtatcc tggtcaccag cttcaaccac 900 atgccgaaga tccggaccct gcgtctccac tccaaccacc tgtactgtga ttgtcacttg 960 gcctggctct cagactggct gcgacagcgg cggaccattg gccagttcac cctctgcatg 1020 gcgcccgtgc acctgagagg cttcagtgta gcagacgtgc agaagaagga gtatgtgtgt 1080 ccaggtcccc actcagaggc tccagcctgc aatgccaact ccctctcctg cccttctgcc 1140 tgctcatgca gtaataacat tgtagactgc cgtgggaagg gactgactga gatccctgcc 1200 aacctgccgg agggcatcgt ggaaatacgc ctagaacaga actccatcaa atccattcct 1260 gcaggagctt tcatccagta caaaaaactg aagcgaatag acatcagcaa gaatcagata 1320 tcggacattg ctccagatgc cttccagggc ctgaaatcac tcacgtcgct ggtgctctat 1380 gggaacaaga tcacagagat tcccaaagga ctgtttgacg ggctggtgtc cctgcagctg 1440 ctcctcctca atgccaacaa gatcaactgc ctgcgggtaa acaccttcca ggacctacag 1500 aacctcaatc tgctctctct gtatgacaac aagttgcaga ctatcagcaa agggctcttt 1560 gctccgctgc agtccatcca gaccctccac ttagctcaaa acccgtttgt ttgcgactgc 1620 cacttgaagt ggttggccga ctacctccag gacaacccca ttgagacgag cggggcccgc 1680 tgcagcagcc cacgccggct ggccaacaag cgcatcagcc agatcaaaag caagaagttc 1740 cgctgctcag gctcggagga ttatcgcaac agattcagca gcgagtgctt catggaccta 1800 gtgtgccccg agaagtgccg ttgtgagggc accattgtgg actgctccaa ccagaagctc 1860 tcccgcatcc cgagccacct ccctgaatat accactgacc tgcgactgaa cgacaatgac 1920 atcgctgtgc tggaggccac tgggatcttc aagaagttgc ccaacctgag gaaaataaac 1980 ttgagcaata ataggatcaa ggaggtgcgg gagggtgcgt ttgatggagc ggcaggcgtg 2040 caggaactga tgctgacggg gaaccagctg gagaccatgc acggacgcat gttccggggc 2100 ctcagcggcc tgaagacact gatgttaagg agcaacctga tcagctgcgt aaacaatgac 2160 accttcgctg gcctaagctc tgtgagactg ctgtccctct atgacaatcg gatcaccacc 2220 atcagccctg gagccttcac cacgctcgtc tccctgtcca ccataaacct cttgtctaac 2280 cctttcaact gcaactgtca catggcctgg ctcggccggt ggctgaggaa acgccgcatc 2340 gtaagcggga accccagatg tcagaagccc tttttcctca aggagattcc tatccaagat 2400 gtggccatcc aggacttcac ctgtgaaggc aatgaagaga acagctgtca gctgagtcca 2460 cgctgccccg agcagtgtac ctgtgtggag acagtggtgc gatgcagcaa caggggtctc 2520 cacaccctcc ccaagggcat gccaaaggac gtgactgaac tgtacctgga aggaaatcat 2580 ttaacggcgg tgcccaaaga attgtccacc ttccgacagc tgacactaat tgacctgagc 2640 aacaacagca tcagtatgct gaccaatcac accttcagca acatgtccca cctctccaca 2700 ctgatcctga gctacaaccg gctgagatgc atcccggtcc atgccttcaa cgggctaagg 2760 tcactccgag tgctaaccct ccatggcaat gacatttcca gtgttcctga aggctccttc 2820 aatgatctga cgtccctctc ccacctggcc ctgggaatca accctctcca ctgtgactgc 2880 agtctgcgtt ggttatcaga gtggataaag gctgggtaca aggagcctgg cattgccaga 2940 tgcagtagcc ccgagtccat ggcagacaga ctcctgctca ccacccccac ccacaggttc 3000 cagtgcaaag ggccagtgga cattaacatc gtggccaagt gcaacgcctg cctctctagc 3060 ccatgcaaga acaacggcac ttgcagccag gatccggtgg agcagtaccg ctgtacctgc 3120 ccttacagct acaagggcaa ggactgcacc gtgcccatca acacctgcgt ccagaacccc 3180 tgtcagcacg gaggcacctg tcacctcagt gagagccaca gagatgggtt cagctgctcc 3240 tgccccctgg gctttgaggg acagcggtgt gagatcaacc cagatgactg tgaggataac 3300 gactgtgaaa acagcgccac ctgtgtggac gggatcaaca actacgcatg cgtgtgcccg 3360 ccgaactaca caggggagct gtgtgatgag gtgattgact actgcgtgcc cgagatgaac 3420 ctctgtcagc acgaggccaa gtgcatctcc ctggacaaag gattcaggtg cgaatgtgtc 3480 cctggctaca gtggaaagct gtgcgagaca gacaacgatg actgtgtggc tcacaagtgt 3540 cgccacggag cccagtgtgt ggacgcggtc aatggctaca cgtgcatctg cccccagggc 3600 ttcagcgggc tcttctgtga gcacccccca cccatggttc tgctacagac cagcccctgt 3660 gaccagtacg agtgccagaa tggggcgcag tgcatcgtgg tacagcagga gcccacttgc 3720 cgctgtcccc caggcttcgc tgggcccagg tgtgagaagc tcatcactgt gaatttcgtg 3780 ggcaaggact cctatgtgga actggcctct gccaaggtcc ggccccaggc caacatctcc 3840 ctgcaggtgg ccactgacaa ggacaacggc atccttcttt acaagggaga caacgacccc 3900 ctggcactgg agctgtacca gggtcacgtg aggctggtgt atgacagcct gagctcccct 3960 ccgaccacgg tgtacagtgt ggagacggtg aatgatggcc agtttcacag tgtggagctg 4020 gtgatgctaa accagaccct gaacctggtg gtagacaaag gagcccccaa gagcctgggg 4080 aagctccaga agcagccagc agtgggcatc aacagtcccc tctatcttgg aggcatcccc 4140 acgtctacag gcctctcagc cttacgccag ggtgcagaca ggccgctggg cggcttccac 4200 ggctgtatac acgaagtgcg catcaacaac gagttgcagg atttcaaagc cctcccaccc 4260 cagtccctgg gggtctctcc cggctgcaaa tcctgcactg tgtgtcgtca cggcctgtgt 4320 cgttccgtgg agaaggacag cgtagtgtgt gagtgccatc cgggatggac tggtccactg 4380 tgtgatcagg aagcccagga cccctgcctt ggtcacagct gcagccatgg gacatgcgtg 4440 gcgactggca actcatatgt gtgcaagtgt gccgagggct atgagggacc tttgtgtgac 4500 cagaagaatg actctgccaa tgcctgctca gccttcaagt gccaccacgg gcagtgccac 4560 atctcagatc gaggggagcc ctattgcctg tgccagcctg gcttcagtgg caatcactgt 4620 gagcaagaga atccatgttt gggagagata gtccgtgaag ccatccgccg ccagaaagat 4680 tatgcctcct gtgccacagc atccaaggtg cccatcatgg tatgccgcgg gggctgcggg 4740 agccaatgct gccagccgat tcggagcaag cggcggaaat acgtcttcca gtgcactgac 4800 ggctcctcgt tcgtggaaga ggtggagaga cacttggaat gtggctgtcg tgagtgttcc 4860 tgagcccctc cccctctgcc gcccactcat cctccgcctt cgggactcca cgtggaacct 4920 ctttgagatt cagaatgaag gagagaaagc ttggagacca agaggcaaaa gagagaatat 4980 taagtatatt gtaaaataaa caaaaaaata gaacttattt ttattatgga aagtgactat 5040 tttcatcttt tattatataa atatatcaca ccgtctgagt atatggacta tacagtgagt 5100 tatttttacc aagttttgtt ttgtgttgtg tatttgttgt gtttttataa acagctgttt 5160 aaaattttaa gacaaaaaaa aaacactaat aaaaatgttt taaacacaag 5210 <210> 8 <211> 637 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(637) <223> LOC689064 <400> 8 gttgtgttga ctcgcaacct caggaacaga caccatggtg cacctaactg atgctgagaa 60 ggctactgtt agtggcctgt ggggaaaggt gaatgctgat aatgttggcg ctgaggccct 120 gggcaggctg ctggttgtct acccttggac ccagaggtac ttttctaaat ttggggacct 180 gtcctctgcc tctgctatca tgggtaaccc ccaggtgaag gcccatggca agaaggtgat 240 aaatgccttc aatgatggcc tgaaacactt ggacaacctc aagggcacct ttgctcatct 300 gagtgaactc cactgtgaca agctgcatgt ggatcctgag aacttcaggc tcctgggcaa 360 tatgattgtg attgtgttgg gccaccacct gggcaaggaa ttcaccccgt gtgcacaggc 420 tgccttccag aaggtggtgg ctggagtggc cagtgccctg gctcacaagt accactaagc 480 cccctttcct gctgttgtct atgcacaaag gttatgtgtc ccctagagaa caactgtcaa 540 ctgtgggggg aaatgatgaa ggcctttggg cagctagctt ctatctaata aatgatattt 600 actttcatcg caaaaaaaaa aaaaaaaaaa aaaaagg 637 <210> 9 <211> 4386 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(4386) <223> Grin3a <400> 9 tcctctgcca cctcagtaaa taagtgggtg tcgcctgaac tgaacagcaa gagaaaagaa 60 gccagccaag tgagagcaca gctcctctgt cactgccgcc cccttgcaag tctggcggct 120 tctcgcgggg ccagacgctg cgccccaggc gccctgcaga tggggtggac agggacccgg 180 agctcaagcc accggtgacc cgcgcgtggc tggccgaccg gccttccccg cttgcagagg 240 atgttaagca gaggagccct ggaaccgcat ccgacactgg ccgacgttcg ctaggctgca 300 acttggaatg cccagggagc ggtcgggctc ctaagaccgc gtcgccgcgt ctagggaagc 360 tgcgctccgg atttggaggc ggagacctca ggcggcggag acctccggcg gcggctgcag 420 agggacgagc cgggcgcagg agggggcgcg ctttctccca gcgggtctca gtaatgagga 480 gactgagttt gtggtggctg ctgagcaggg tctgtctgct gctgccgccg ccctgcgcac 540 tggtgctggc cggggtgccc agctcctcct cgcacccgca accctgccag atcctcaagc 600 gcatcggaca cgcggtgagg gtgggcgcgg tgcacttgca accctggacc acggccccac 660 gcgcagccag tcgcgctcag gaaggcggca gggcgggtgc ccagagggat gatccagagt 720 cagggacgtg gcggccaccg gcgccctcgc aaggcgcacg ctggttgggg agcgccctgc 780 atggccgggg tccacccggc tcccgaaagc tcggggaggg cgcgggggcc gagaccctgt 840 ggccgcggga tgccctactg ttcgctgtgg aaaacttgaa ccgtgtggaa gggctcctac 900 cctacaacct gtctttggaa gtagtgatgg ccattgaggc gggcctgggc gatctgccgc 960 ttatgccctt ctcttcccca agctcaccgt ggagcagtga ccctttctcc tttctgcaga 1020 gcgtgtgcca caccgtagtg gtacaagggg tgtcggcgct gctggccttc ccccagagcc 1080 agggcgaaat gatggagctg gacttggtca gctctgtcct gcacatccca gtgctcagca 1140 tagtgcgcca cgagtttccg cgggagagtc agaatcccct gcacctacag ctgagtttag 1200 aaaactcact aagttctgat gctgatgtca ctgtctcaat cctgaccatg aacaactggt 1260 acaattttag cttgttgctc tgccaggaag actggaatat cacggacttc ctcctcctta 1320 cggagaataa ctccaagttc cacctcgagt ctgttatcaa catcactgct aatctgtcct 1380 ccacaaagga ccttctaagt ttcctgcagg tccagatgga caacattagg aacagcacac 1440 ccacaatggt gatgtttggc tgtgacatgg acagtatccg gcagatattt gaaatgtcca 1500 cacagtttgg gctatcacct cctgaacttc actgggtttt aggagactcc cagaatgtgg 1560 aggaactgag gacagaaggc ctgcccttag ggctcattgc tcatggaaaa accacacaat 1620 ctgtctttga gtactacgtt caggatgcca tggagttggt tgcaagagct gtagccacag 1680 ccaccatgat ccagccagag cttgctctcc ttcccagcac aatgaactgc atggatgtga 1740 aaaccacaaa tctcacttct ggacagtatt tatcaaggtt tttagccaac accactttca 1800 gaggtctcag tggttccatc aaagtaaagg gctccaccat catcagctca gagaacaact 1860 ttttcatctg gaacttgcag cacgacccta tgggaaagcc aatgtggact cgcctgggca 1920 gctggcaagg aggaaggata gtcatggact ctggaatatg gccagagcag gcccagaggc 1980 acaaaaccca cttccagcac ccaaacaagt tacacttgag agtggtgaca ttgattgaac 2040 acccatttgt tttcacgaga gaagtagacg atgaaggctt atgccctgct ggacagctct 2100 gtctagaccc tatgactaac gactcttcca tgctggatcg tctgtttagc agcctgcata 2160 gcagtaatga cacagtgcca atcaagttca agaagtgctg ttatgggtac tgcatcgatc 2220 tcctggagca gctagcagaa gacatgaact ttgactttga cctctacatt gtaggggatg 2280 gaaagtacgg agcttggaaa aatggtcact ggactgggct ggttggtgat ctcctgagtg 2340 ggacagccaa catggcggtc acttctttca gcatcaatac cgcacgaagc caggtgatag 2400 atttcaccag ccctttcttc tcaaccagtt tggggatctt agtgaggact cgagacacag 2460 cagctccaat tggagccttc atgtggccac tccactggac catgtggctg ggaattttcg 2520 tggctctcca tatcactgcc atttttctca ctctgtatga atggaagagc ccctttggta 2580 tgacccctaa ggggaggaac agaaacaaag tcttctcctt ctcctcagct ttgaatgtct 2640 gctatgccct tctgtttggc agaacagcag ccatcaaacc cccaaaatgc tggactggaa 2700 ggtttctgat gaatctttgg gccattttct gtatgttttg cctttctaca tacacagcga 2760 acttggctgc tgtcatggta ggtgagaaga tctatgaaga gctttctgga attcatgacc 2820 ctaagcttca tcatccttct caaggcttcc gctttggaac tgtccgggaa agcagtgctg 2880 aagactatgt gcgccagagc ttcccagaga tgcatgagta catgagaagg tacaacgtgc 2940 cagccacccc tgatggagtg cagtatctga agaatgatcc agagaaacta gacgccttca 3000 tcatggacaa agcccttctg gattatgaag tgtcaataga tgctgactgc aagcttctga 3060 ccgtaggaaa gccatttgcc atcgaaggat atggcattgg tctccctcca aactctccat 3120 tgacctctaa tatatctgag ctcatcagtc agtacaagtc tcacgggttt atggatgtgc 3180 tccatgacaa gtggtacaag gtggttccct gcggaaagag aagctttgcc gtcactgaga 3240 ctttgcaaat gggcatcaag cacttctctg gactcttcgt gctgttgtgc ataggatttg 3300 gtctctccat cctgaccacc attggtgaac acatagtgca cagactgctg ttaccacgca 3360 tcaaaaacaa atccaagctg cagtactggc tgcacacgag tcagaggttt cacagagcat 3420 taaacacgtc attcgtagaa gaaaagcagc cacgttccaa gacaaaacgt gtggagaaga 3480 gcagatggag aagatggacc tgcaagacag aaggggactc tgaattgtct ctgtttccta 3540 ggtccaacct gggaccccag cagctcatgg tatggaatac ttccaatctg agtcatgaca 3600 accaacgaaa atacatcttt aatgacgagg aaggacaaaa ccagctgggt acccaggccc 3660 accaggacat ccctctccct cagaggagaa gagagctccc tgcctcactg accaccaatg 3720 ggaaagcaga ctccctcaat gtaactcgga gctccgtgat tcaggaactc tctgagttgg 3780 agaagcagat ccaagtgatc cgccaggagc tgcagttggc tgtaagcagg aagacagagc 3840 tggaggagta tcaaaagaca aatcggactt gtgaatccta ggctgtgtct ccccccactt 3900 tctcagcccc tggtactctg aagcccttga gacactttgt aaagcccttt tatattcctt 3960 gacaaaggtg tggggtctgg caatgaagtg tgctgttctc tgcctaaggt gcagcagcag 4020 cagcagcagc agttcttccc acaaaggccc ccaggtcttc agggtagtaa tcgttccgat 4080 agtaggaagc tagggttagt cgggagtaaa gtctgtctga ggggatcggc gagctgccag 4140 acaactctgg ctcctctcaa ccttttcacc tggtgccaca aaaaaaattc tggtttttag 4200 ccctttctct gcacctcaac aagagataaa aagccgtcgc tcatacctgt gtcttactgg 4260 gttggttttt aatattacta caaaacaaaa ttatccaatg ttgcagattt gatacaactc 4320 cccaatctag atctgatcta acattctgaa tgagcagggt aggagccagg aaaacgggac 4380 agaaca 4386 <210> 10 <211> 4025 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(4025) <223> Zfp317 <400> 10 agtagaagcc attactgtca aggaactact ttaataagac acatctgcta aagaatgttt 60 ggggtttctc ccgtgtttgg tcgggaccct tctgttcccc gaagcgttct gaagcattcg 120 gggcctttag gtgaacttct agttcttccg ccttagctgc ggagacttcc gcttcctgca 180 ttccaccctc tggatctcac aatgtagtcc agactggctt ttcaaactta aaatttttat 240 gttctgactt tcttctgtcc tgggattata gacaagattg cgatccagtt tccagtggtg 300 cttgttgctg acccaaagca gagtttctac gaggttgcct atgcttggtg gagacaggat 360 ccagggagaa agaaaggaag cagatgtctc attataaggt ggtttgtaat tctcaatcct 420 caaaccttct atgtacgaga ggttaataat ctgtctgatt atgaatcaag aggaaatgtc 480 aagataccaa attcagtgtt ctcactaagt atgagagaca gcctttgaag atcccccttg 540 tggcagttgt cagcttggaa aagcagtgct tcttcaagta ctcccacatt cagctaaggt 600 tactgtgccc cacaaatggc taccatctgt ctgtctccca agtttgataa ccaggaatca 660 gaatttcctc ttccatcaaa atgtgattct tgtcatcaga gtttgagttt gtttgcttgc 720 cgtgctccag agcctgatac accagctcat gtttattctc aggagttcgt gacatttcaa 780 gatattgctg ttgactttac tgagaaagag tggcccctgc tagattcttc tcagagaaaa 840 ctgtacaaag atgtaatgct ggagaattat agcaatctaa gttcattggg ttttcaggtt 900 ggcaaacccc gcctcatctc acacctagag caagaagagg agctgagaat ggaggagaga 960 ggcattcagc agtgtccttc tccagattgg gaaactacat ctaagatcaa atggtccatt 1020 cttatggaag atatttttgg gaaggaagca tctgatggtg taagattgga agcatctcat 1080 cttttggaga aatcatctga ctttacccat ttatttgaag tccttaatat tggtcgtcac 1140 cttgcacagc caataggaat gcccacaagc aagagaccct atcaccacca cacctgtgga 1200 gctgctttca agaacaggat tcacctgact cagcacataa gcatgtatga tgggagaaaa 1260 atgcatgaat gtcaccagtg ccagaaagcc ttcaccacca gtgcttctct tacaaggcac 1320 tgtagaattc acactgggga gaagccttat gagtgcagca gctgtggcaa agccttcaat 1380 gacccatcag ctctaaggag ccacacaaga actcacctca aagaaaagcc ctttgactgt 1440 agtcagtgtg gtaatgcctt ccggaccctc tctgctctga agatacacat gcgagttcac 1500 actggtgaaa gaccctacaa atgtgacgag tgtggcaaag cctatggcag gagctgccac 1560 ctcattgccc acaagcgaac acacactgga gagaggccct atgagtgtca ggactgtgga 1620 aaagccttcc agcacccctc ccacctgaag gagcatgttc ggaaccatac tggggaaaag 1680 ccttttgagt gtatacagtg tggcaaagcc ttccgatgga agtccaactt caatttgcat 1740 aagaagaacc acatggtgga aaaaacttat gagtgcaaag actgtggaaa gtccttcagt 1800 gatctcctat caagaaggaa acacatgagg agtcacattg taaagaaacc agtcgagtgt 1860 catcaatgtg ggaaaacctt tcgaaaccag tccatcctaa aaacacacat gaactctcac 1920 actggggaga aaccttatgg ttgtgatctc tgtggcaaag ccttcagtgc tagttccaac 1980 ctcactgcac acaggaagat tcacactcaa gagagacact atgaatgttc gtcctgtggg 2040 aaggtctttg gtgattacct gtcacgaagg aggcacatga gcatccatct tgtcaagaag 2100 cgtgtggaat gtagacagtg tggaaaagcc tttaggaacc aatctaccct gaagacacac 2160 atgagaagcc acaccggtga gaagccatat gagtgtgacc attgcggaaa aggtttcagc 2220 ataggatcta accttaatgt tcatcggagg atccatactg gggaaaagcc ttatgaatgt 2280 cttgtttgtg gaaaagcctt cagtgaccat tcatccctta ggagtcatgt gaaaacccac 2340 cgggggagaa gctctttgca ccatctctgt ggaaaaggtt tcagtgaata ctcagatgca 2400 gaggaaacat ggcaagtgta agtcgtcaag aatctttcat gacctctcca tatacagaac 2460 gcaaaagatc agtttgtaga aagactgaga agacctaagt tggtattcag caactgggat 2520 ctcttgagaa cctagcaact gtgaaaaatt tgtattgagt agcaagaaac tttcaacata 2580 tattgtgctc tgaacttagg cagagagtct tcagtgtgga catttagtat taaagtcagc 2640 aacactttgt gggcacacca gagtgaatcc tatcattcag tgattagaga agtctttcct 2700 catctcacct ttgttcctca tgggagaaat cagagttttt ttaaaaaaca aaacaaaaca 2760 aacaaacaaa caaaaaaaac ccctcagaaa taaccttgga aaagtacatt aaaaatagga 2820 aagcaacctg gccatttctt tattgatttt ggctcagaag acaagaatgc ttctttcttt 2880 ttaaaaagaa aaatctggca gaggcagtac atggcactca aattctgttt ataaaaatat 2940 tcttttaggg ctttagtcag tagcattgga tctcaacctg gagcactttt gctctccagg 3000 gcagttgtgt ctgggaagat tttggtttta agaatggaga gaggtgctac agacgatcac 3060 agatgctatc aaatagccta tgatatatag aagtcttcct atgtgtacaa ctgtaaaagt 3120 actgagtttg agaacagtct cattcattcc ttgggtactg tgattcctgt gaacactaac 3180 aggagaaaat ttttacagtt ttttaaaaga aaaaccatcg cattgcagtt ctctctgaaa 3240 atgtatgaaa acgtacactg cttataactt tatgaaaata attttagcca tagtcccctt 3300 gtatgtgaat ttaattagag ttgtatttaa aagtcatttt ttggtgataa ctgactccag 3360 ctctttagtt tttttgatct ttttatcttt aggattatgg ttctctaaat aactttgtcc 3420 ccatcataaa taattaaata tagtattttt tactatagct ttgtaaatta tatctttatt 3480 tcactttagt aaccttaaca tgaccactgg catatttaga attgtgtaat gttatgcact 3540 gggtaatata ggtattttta ggtacctttg tcatatgcat tgtggtcaaa gcatgaagct 3600 tcctaacaga tagtactttt ggttttgcct ttctgtccaa aagacctata agatttcgca 3660 tattcattta aacaccttct atagcagaag aataacagtt ttatctatag tgccactata 3720 agaaatcttt tttagttttt catgcaactc atattctcta catgccatga cccctggata 3780 ttcactcatc aacagagata catgtgtggt attctgagaa aaagctcttg gggaaaaaat 3840 acctgatttt tgttttttaa ttcgttgtgt gaccctgaag atgaaaacca cagtctaaaa 3900 agaatagaat agagaagtca cagtgaccct agtctgtatt tttgcttctg aaagagttta 3960 cattggtatt caatattata tctagacttt ctcttccccg agaaattaat aaaaaaaaaa 4020 aaaaa 4025 <210> 11 <211> 1610 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1610) <223> Znf597 <400> 11 ggagcatggg agcgtgggag ttttgtggtg gcctccgcct cctttgtagc gtctcggctg 60 ggcgtggctt catgctgctt ctgccgggtt gggcgaggct gtcagtgctc ccgggctggt 120 gagtggccgc ttcaaggctg ttttggagaa agaagccttc acctcagatt ctcaaaggag 180 cttgaaggtt ccgaggagcc tgagggtgga gtggaaaggc ctggcagcgg agttggagac 240 tctctgctcg aagtgttgtc ccaacgtagg gacttgaagg agcccttcgt ttccccagat 300 ggcgtccacg ctccccacat ccgatgagca gggaccactg ctctttgaag atctggatgt 360 gtatttttct caagaggaat gtgtgagtct gcactcttcc cagaagaccc tcagcagaga 420 agccccgttg gagtcttttg aggatttgaa cttgacaggg gaagaccgga ctgagaccag 480 tcagaagtta agcctagagc ctctagaact tgaagagctg tccctagaaa cgtactccac 540 tgctgtaccc cttgtccgct acttagagca gcctgaggag gatgttgaag tacatgaaag 600 gaaaatgtca ggcggaactt tgacttgcaa gaccaagctt gtaaacctct tggttactat 660 tgacaaccaa actccattag aagagttatc tcagtgttta ggagtcaaaa cactttcaga 720 tattattgaa gttccctggg aagaagccaa aaatgtgttc cagtgtcctg actgtgacca 780 aagcttcagt gataatacat accttgtttt gcatcagaaa attcattcaa gagagagaaa 840 gtataaatgt ggtacctgtg agaagacctt cagtcaccga accaacctga agacacacag 900 gcgaatccac accggagaga agccttacaa gtgtaccgag tgtgctgcca gcttccgaca 960 gcagtcacac ctgacccggc acatgaatag ccatttaaag gagaaaccat acacatgtag 1020 tgtatgtggg agaggtttta tgtggctccc cggattggca gaacatcaga agagtcatac 1080 tgatacggag tcttacgaga gtgctgacca tgatcaggaa acaagtctgg ctttgcctga 1140 agaaagaggc tcttcagaca caccatccca gcacgcacag tgtgtgggga cctcggagca 1200 gccctcagag cctgctctcc ccgacaaaga caaccataag gagaatgcta aacactgcag 1260 catcgatgat gaagacttct tttccttctc cagattcaaa cccttacagt gtcttgattg 1320 tgacatgact tttccttgtt tctcggagct tgtctctcac caaaccatcc acgacatgga 1380 gaaaactcat aagtgcaaaa catgtgcaaa gacctttgct ttagagtccg acctcgcgag 1440 tcacgagaag agccacagaa gagaggagcc ctttaaatgt acagtgtgtg ggaagagctt 1500 cagagtaaac gtgcagctca tcgctcataa acgaacccat aggagaaaca gcaagtaaat 1560 acaggctttt gctactgtta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1610 <210> 12 <211> 3014 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3014) <223> Avil <400> 12 gaaacaggct tcaggacccg aggtcgcctg cttcgggacc gctcgtcagt acttcacctg 60 ctgctttgct gggaaaggga gaacagaggg tcagttccag gaagacagac actatgtctc 120 tgagcagtgc cttcaggact gtgaccaatg accccgggat tatcacgtgg agaattgaga 180 aaatggagct ggtgctggtg cccctgagtg ctcatggcaa cttctatgag ggagactgct 240 acatcatcct ctcgacccgg agagtgggca gccttctctc ccaaaacatc cacttttgga 300 tcgggaagga ctcctcccaa gatgagcaga gctgtgcagc catctatacc acacagctgg 360 atgactacct gggaggcagc cccgtgcagc accgtgaggt ccagtaccat gagtctgaca 420 ccttccgtgg ctacttcaag cggggcatca tctataaaaa ggggggtgtg gcctctggga 480 tgaagcatgt ggagaccaac acctatgatg tgaagaggct gttacatgtg aaggggaaaa 540 gaaacatcag agccactgag gtggaaatga gctgggacag ttttaaccaa ggtgatgtct 600 tcttgctgga cctcgggatg gtcatcatcc agtggaatgg cccggagagc aacagtgggg 660 aacgcctcaa ggctatgctt ctagcaaagg acattcggga cagggagcga gggggccgag 720 ctgaaatcgg ggtgattgag ggagacaaag aggcagccag cccagaactg atgacggttc 780 tccagaatac ccttggccga cgctccatta tcaagcccgc agttcctgat gaggtcaccg 840 atcagcagca gaagtcaacc atcatgttgt atcatgtctc cgacacaact gggcagctgt 900 cggtcacaga agtggcaaca aggcccctgg tccaggagct actgaaccat gatgactgct 960 atatcctgga ccaaagtggc accaagatct acgtatggaa aggcaaagga gccaccaagg 1020 tggagaaaca ggcggccatg tccaaagccc tggatttcat caagatgaag ggttatccca 1080 gcagcaccaa cgtagagacc gtcaacgatg gcgcagagtc ggccatgttc aaacagttgt 1140 tccagaaatg gtcggtgaag gaccagacca ctggcttggg gaaaacattc agcattggta 1200 aaattgctaa aatcttccag gacaagttcg acgtgactct gctacacact aagccagaag 1260 tggctgctca ggaaagaatg gtggacgacg gcaacggcaa ggttgaggtc tggagaattg 1320 agaacctgga gctggtccct gtggaatacc agtggcatgg cttcttctac gggggagact 1380 gctatctggt tctctacacg tatgatgtga acgggaaacc ctgttacatc ttgtatatct 1440 ggcagggacg ccacgcttcc caggatgagc tggcagcctc ggcctaccag gcggtggagg 1500 tggatcagca gtttggtgga gccccggtgc aagtccgggt tagcatgggg aaagagccac 1560 gccacttcat ggccatcttc aaagggaagc tggttatcta tgagggcggg acttccagga 1620 agggaaatgt ggagcctgac cctccagtaa gactcttcca gatccacggg aacgacaaat 1680 ccaataccaa agcagtggaa gtctcggcct ccgcttcctc cctcaactct aatgatgtct 1740 ttctgctttg gactcaggcg gagcactacc tgtggtatgg caaggggtca agtggggacg 1800 aacgggcgat ggctaaggag ctggcagagc ttctctgtga tggtgacgca gacactgtag 1860 ctgagggcca ggagccacct gagttctggg accttctggg aggaaaagcc ccctacgcta 1920 acgacaaaag gctgcagcag gaaaccctgg acatccaggt ccggcttttt gaatgttcta 1980 ataagaccgg ccggttcctt gttactgagg tcacggactt cacccaggat gacctgagcc 2040 caggtgatgt gatgctcctg gacacctggg accaggtgtt cctgtggata ggagcggagg 2100 ccaatgccac agagaaggag ggggccctct cgactgctca ggagtacctg gtaacacacc 2160 ccagtggccg agaccccgac acaccgatcc tgatcatcaa acagggcttt gagcccccca 2220 ctttcacagg ctggttcctg gcatgggacc ctcacatttg gagtgaagga aaatcatatg 2280 agcagttaaa gaacgagctg ggagatgcca ctgctatcgt gcgaatcacc acggacatga 2340 agaacgcaac cctctccctg aattctagtg aaagtgggcc aaagtactac cctgtggagg 2400 ttctgctgaa aagtcaggac caggagctgc ctgaggatgt ggaccccacc aaaaaggaga 2460 attacctctc ggaacgagat tttgtctctg tgtttggcat caccagaggg cagtttgtct 2520 ctctgcctgg ctggaaacag ctccagctga agaaagaagc aggccttttc tagaacaagg 2580 cgtgaccaca ggagagggct aatgcagtgc caacatcagc aaaggttcat ctacgactga 2640 gcccgacaca cgctgcccta gatacgacag atctcagggt cgtgtattct gtcttttgca 2700 ttcatccttg catttctagg ttgctataca ctagatgcca actatttgcc ttttagcttt 2760 ggtggtcctt tagcgaaagc ctcagcagag agagtgaagg cataaaggta gagagaacta 2820 gaaactaagc tcaaaatatt taatgcatca ggacccacat ttgctttgaa ctataccctg 2880 caatccccaa agtggtggag tcagcacacg cttcctgcag gccggactcc aaatgcccag 2940 gtctaccatg tgccacacca tgttcatgtg ccacaccatg ttcagccttt caaataaaga 3000 ggccatgtgc catg 3014 <210> 13 <211> 3165 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3165) <223> Clec14a <400> 13 cggcaagcca gagaacttgg gagcagctgt gggctcttga gtctccagga tgaggccggc 60 tcttgccctg tgcctcctct gtcctgcgtt ctggccccgg ccagggaatg gcgagcaccc 120 cacggccgat cgcgcagttt gttcggtccc gggggcttgc tacagcctgc accacgcagc 180 catgaagagg agggcggcgg aggaggcctg tagcttgcgc ggcgggactc tcagcaccgt 240 gcagtccggc tctgagttgc aagctgtgct caagctcttt cgtgcaggtc ccgggcctgg 300 tggaggctcc aaagacctaa tgttctgggt ggctctggag cgtgaccgtt cacagtgcac 360 ccaggagaga gagcctttga ggggtttctc ctggttgtac acggactcag aagactcgga 420 gaacagaaca ctaccttggg tggaagagcc acaactttct tgcactgtac gaaagtgcgc 480 tgtgctccag gccaccgggg gagtggagcc tgctggctgg aaggagatgc gctgtcaaca 540 gcgcgccgat ggctacctgt gcaagtacca gtttgaggct ctgtgccctg cgcctcgccc 600 gggagccgcc tctaacttaa gtttccaagc tcccttccgg ctgagcagtt ctgccctgga 660 cttcagccct cctgggaccg aggtgagtgc gatgtgtccc agggacttct cagtctcctc 720 catctgcgtc caggaagaga caggcgcacg ctgggatggg cttttccctg ggagcttgct 780 ctgcccctgt tctgggaggt acctccttgc tggcaagtgc gtggagctcg ctgactgcct 840 agactacttg ggaaacttcg cctgcgaatg tgctgtgggt tttgagctag ggaaggacaa 900 acgctcttgt gagaccaaag cggaaggcca actaaccctc gaggggacca agttgcccac 960 tagaaatgta tcagccactc cagccagtcc tgtgacaaac aaatcgtggc caggtcaggt 1020 ctatgacaag ccaggagaga tgccccaggt cactggacaa gaccgtattg cgacatctgt 1080 tcctgagatt cttcagtggg gaacacagag tactttacct actgttcaaa cgtccccaca 1140 aaccaagcca aaagtcacca tcacaccatc aggaagtatg atgcccacat tgaacttcgc 1200 atcttcccct cctgtttctc tgactttcga ctcctcctcc acggtggtct tcgtacttgt 1260 gagcatagca gtaatagttt tggtactctt gaccattaca gtgctgggac ttttcaaact 1320 ctgcttccac aaaagccctt cctccaggac aaggaaggga gctttggact cacagggtgt 1380 ggaatgtgat gcagaggcca cctctctgcg gcacaattct gcacagtgca cggacactgg 1440 agggaagggt gcctgagggg ctgagctgag ggcacttcac tagttgggtt ctctcttgga 1500 tcaggacaca cttagggaaa cagcccaatg cccacatctt gtctagattt ttttcagttc 1560 caacaattgg gaaaagaagg gattttgcaa tgatgattac tttggaagtt ccccttccca 1620 taaattctct tttttttcca ctaaggagct aaatctgaaa gtcacactag tcccctgaag 1680 gtgaagaggg ggaggctatg gactggtgga gcacaggatg gcaaatggca ggaggcggtt 1740 ttctgtgttc tgagggaatt tggagaagtg cttgtatatt tcccagtctt gggaacaaat 1800 aaataaataa cactataatt tttggaacgt ttactttcac ccaaaatgaa aaaggaaata 1860 gctatattat tcaggctagg aatatattag cttgaaaatt tcaggtaaat aataaaacat 1920 cgctgagaac ccagactaat atgtttgact tatgcaaagg gtgttcttta ggagtacaac 1980 gttctggaga tagcaactgg ctatggggta tgctgggaag acacacagaa gtaaacgctg 2040 gtgttttgag gggaagtcct tataccctag ctccttcaga actagtgaag tttcccttta 2100 ttcttttatc ctttgctttc aaagtcactg ggactgtgct ctgctataaa tcctaagtgc 2160 aaggttgcca gtttctgact ctagaagcaa attacagttg accaccaatc caagtgttta 2220 ctgtgtgtcc ttgcccaagg aaacaaatga tttgtgtctt cgttttccaa tgtttgtgtt 2280 ctccagtgta atgaccttcc tctccaagcc accttgtaga catcaagatg ctgatcctca 2340 cttccaatta cgatgatgtt aattctcaat taaaacgtta atgctaagta ttgatttgaa 2400 atcttctggg tgcattaaag caaaaggaag cttggcttct tccaaagttg caagattctt 2460 gtgccctatt taatccatga gggtgggggt ggggacactt gaatgtcaac ccatttctgt 2520 ttcttctcaa tagattgtga atgcaatgac aatgtgtgag tatcagggga ttgttacaac 2580 tgcacaagag tcttagcagg caaaactgca ggaaatggct ttctgcagaa ttaatagtgt 2640 aaaaaagaaa taataaataa aacctaacat cttgttatga cttgagatgt tagcatataa 2700 taaaaaaaaa tcacacattc aggtggtaaa taattaaggc ataataataa taataatatc 2760 tggttgaatt caaagacctt ggagaatatt tcagttagag tgctgagatt tttgtaagtg 2820 ttgtaaagtt gttgtgtgaa gggaaataga gaaataaact tacttgtggg agaaaatgaa 2880 agtagaaaaa acttggacta tatttttcta gaatcatttt tatactcttg attgtactaa 2940 gagttgattt aatgttagca aataaccaat aataaaataa cctagaaaat taagagagtt 3000 caatatatga atctgtgttt taaatataaa tctacgtgct taatattgta tcactgaagg 3060 gaaaaattga tagaaagctt gcttcataag ttgaatatgg ctttaaatag ttacagttaa 3120 ataaaatcac aaatgaattc aaaaaaaaaa aaaaaaaaaa aaaaa 3165 <210> 14 <211> 1273 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1273) <223> Haghl <400> 14 aacctgcaga gattaagggt gacctgggtt cctgccaccg tccatcaggt ctctgcatca 60 ctcacccagg atctcgactg aggagtggtg atgttgcggt gggcagcggc cacactctct 120 ccaggactag atcggcggct catgtgcgag tgaacgaggt cgacccagtg tgtgtggctg 180 acccgcccgg tgcaactcag aagggattcc ttaggttgag gaactgcgga ctggctgagg 240 tctgcgacca tgaaggtcaa agtcatcccg gtacttgaag acaactacat gtacctgatc 300 attgaggaac acacacggga ggccgtggct gtagacgtgg ctgtgcccaa gaggctgctg 360 gagattgctg gccgcgaggg agtgtctctg accacggtgc tgtccaccca tcatcactgg 420 gaccatacac gtggaaatgc ggagctggcg cgcctgcagc caggactggc tatcatggga 480 gcagatgagc ggatctgcgc gctaacccgc aggctggaac acggagagga acttcagttt 540 ggggccatcc acgtgcgatg cctcttgacg ccgggccaca cctctggcca catgagctac 600 ttcctgtggg aggatgaatg cccggaccca ccagccctct tctctggaga tgctctgtca 660 gtggcaggct gtggctggca cctggaggac actgcccagc agatgtacca gagcttggcc 720 aagactctgg gtacccttcc accccagacg aaggtgttct gtggtcatga gcatacgctg 780 agcaatcttg agtttgcaca gaaagtggag ccctgcaaca gccacgtgca agctaagctg 840 tcctgggccc agaagaggga tgatgatgat gtacctactg tgccttcaac gctgggcgag 900 gagctcatgt acaacccttt cctaagggtg acagaggatc cagtccgtgc gttcacaggc 960 caggtggcac cagcccaggt cctggaggtg ctctgcaggg agcgagcacg cttccagctt 1020 gcttcggagc ctccacagcc ccaggtccgg gcactcctgg ccttacaatg ggggcttctg 1080 agcacaggcc aggaaaagtg aactgtgtgg ggagcctgct tgtctccaca ctcctctgaa 1140 cctcaggccg actggaaccc tgccaccctg actgcttatg gagccataca agtgtggtct 1200 gtaggagctc ttgtgggtcc agagacatac atcctgggga ctgaggaggg taaataaaac 1260 tttgaaaggc gca 1273 <210> 15 <211> 1221 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1221) <223> Rab8b <400> 15 ttggcggaca cgccccctcg ccagaggccc cctccgtgcc gctttccacc gcctccttgc 60 tctgggcggt cagagagggc cggagcgaga agatggcgaa gacgtacgat tatctgttca 120 agctgctgct catcggcgac tccggcgttg gcaagacctg cctcctgttc cgcttctcag 180 aggacgcctt caacaccacc tttatctcca ccatcggaat tgattttaaa atcagaacga 240 tagaactcga cggaaagaaa attaaacttc agatatggga cacggcgggc caggaaagat 300 tccgaacaat tacaacagca tactatagag gagccatggg aattatgctg gtctatgaca 360 tcaccaatga aaaatccttt gacaatatta aaaattggat aagaaacatt gaagagcatg 420 cctcttcaga tgttgaaaga atgatcctgg gtaacaaatg tgatatgaac gacaaaagac 480 aagtgtcgaa agaaagaggg gagaagttag caattgacta tgggattaaa tttttggaga 540 caagtgcaaa atcgagtaca aatgtagaag aggcattttt tacacttgca cgggatataa 600 tgacaaaact caacagaaaa atgaatgaca gcaattcatc aggagcaggt gggccagtga 660 aaataacaga aagccggtct aagaagacca gtttcttccg gtgttctctg ctttgatgaa 720 ctcctcactt ctgagagact gcagaatacc tagagggccc ttccccgcct ctctgaaagc 780 acaggctacc cagcctcaga gtcacctcac ccggctgctg cggagagtac cctggaactc 840 tgacctctca acacagaccg ccaagtggat cccagccttg tggcctagca aaagagcggg 900 ctcctttctt taaacatgga agcaatgacg tggagacaca cgtaggacct aactggtttt 960 tccttgtttt actacctgtc ctggaagctg ctgtctttct ttgcacatga atgtcagcct 1020 ttccctgata cagcataatc tcagactctt aattgagcac tttagtggct tgaagttcta 1080 gacttgtata tttggggatg tttaaagatg gcagagcatt gggggttggg gatttagctc 1140 agtggtagag cgcttgccta gcaagcgcaa ggccctgggt tcggtcccca gctccaaaaa 1200 aaaaaaaaaa aaaaaaaaaa a 1221 <210> 16 <211> 1300 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1300) <223> Thrsp <400> 16 cagccatgca agtgctaacg aaacgctacc ccaagaattg cctgctgaag gtcatggatc 60 ggtactcggc tgtggtgcgg aacatggagc aagtggtgat gatccccagc cttctgaggg 120 atgtggagct gagtgggtac ggaggctcgg tccaggacgg agcccccgat ctctatacct 180 acttcaccat gctcaagagc atctgtgtag aagtggacca cgggctgctg ccgcgggagg 240 aatggcaggc caaggtggca ggcaatgaag gcagtgaggc tgagaatgag gctgctgaaa 300 cagaggaggc tgaggaagac aggctttcgg aggagctgga cctagaagcc cagttccacc 360 tgcacttctc cagcctccat cacatcctta cccacctgac ccagaaagca caggaggtga 420 cgcagaaata ccaggaaatg acggggcagg tcctgtaggt cttcgactct atggaagatc 480 actttacacg agagggaaga cgatgaggac ccagcggtgc atcagccccg agaccaggaa 540 ggaagacctg gacccaggtg gatgcaaagg cggctcctgt ccctgggtgt cccccacctc 600 cctctgagcg catctgtgga cttggctgca ggctcacctt taagatgtct gttgtgattc 660 ccaacttctc ttccatgtct tagcagtttg aggttcacag gcagcaagga tcagtagaag 720 gcagaggtaa tagcaagcgg ccagagttca catcccatcc ctgggatgtc ctttagtgcc 780 tggggtcaca gttactcttt catgtataaa gcagggacgc tgtatttacc tcacaaggtt 840 actaaacgga cacggaatca aaggcacctg tcacgtgcgg atgtctgaac agctggtgtt 900 tctcttacct tcctcagaga gcatgctctg tgtagctctt gcttttgacc cccaacccca 960 ggaaaaggtt gaggtagttg agtgtgtggg atgagcttct catcctgttg gatctgatga 1020 ggctgagcac aagtgaacta tgcaactatt atagtagcaa ttaaaaaata catggcatgc 1080 tgatcttttt tttttcttct tcttattgat tcttcatgaa tttcacatca tgacccccag 1140 tcccattcat cttcgtccct ccatatctgc cctccaccct tgcaacttcc tccacaaaag 1200 aaaacaaaca aataaacaaa actttgctgt ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1260 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1300 <210> 17 <211> 3648 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3648) <223> Zeb2 <400> 17 atgaagcagc cgatcatggc ggatggcccc cggtgcaaga ggcgcaaaca agccaatccc 60 aggaggaaaa acgtggtgaa ctatgacaac gtagtggacg caggttccga aacagacgag 120 gaggacaagc tgcacattgc tgaggatgac ggcattgcaa accctctgga ccaggagacg 180 agtccagcta gcatgcccaa ccacgagtcc tccccacaca tgagccaagg cctgctacca 240 agagaggaag aagaagacga gataagggag agcgttgtgg aacacagctg gcacagcggt 300 gagattctgc aagcctctgt agacggtcca gaagaaatga aggaggatta tgatgctctg 360 gggccagaag ccacgatcca gaccacaatt aacaatggta cagttaagaa tgcaaattgc 420 acatcagact ttgaggaata ctttgccaaa agaaaactgg aggaaagaga tggccacgca 480 gtcagcattg aagagtacct tcagcgaagc gacacggcca ttatttaccc agaagcccct 540 gaggagctgt ctcgccttgg cacgccagag gccaatgggc aagaagaaaa tgacctgcca 600 cctggaactc cagatgcttt tgcccaactg ctgacctgcc cctactgcga ccgcggctac 660 aagcgcttga catcgctgaa ggagcacatc aagtaccgcc acgagaagaa tgaagagaac 720 ttttcctgcc ctctttgtag ctacacgttc gcctaccgca cccagctcga aaggcatatg 780 gtgacgcaca agccagggac agatcagcac caaatgctaa cccaaggagc aggtaaccgc 840 aagttcaagt gcacagagtg tggcaaggcc ttcaagtaca agcaccacct gaaagaacac 900 ctgagaattc acagtggtga aaaaccttac gaatgcccca actgcaagaa acgcttctct 960 cattctggtt cctacagttc acatatcagc agcaagaaat gtattggttt aatctcagta 1020 aatggccgaa tgagaaacaa tatcaagacg ggttcttccc ctaattctgt ttcttcttct 1080 cctactaact cagccattac tcaactaagg aacaagttgg aaaatggaaa accacttagc 1140 atgtctgagc agacgggctt acttaagatt aaaacagaac cactagactt caatgactat 1200 aaagttctta tggcaacaca tgggtttagt ggcactagtc cctttatgaa cggtgggctt 1260 ggagccacca gccctttagg tgtgcaccca tctgctcaga gtccaatgca gcacttaggt 1320 gtagggttag aagccccttt acttggattt cccactatga atagtaatct gagtgaggta 1380 caaaaggttc tacagattgt ggataatacg gtttctaggc aaaagatgga ctgcaagact 1440 gaagacattt caaagttgaa aggttaccac atgaaggatc catgttctca gccagaagaa 1500 caaggggtta cttctcctag tattccagcc gtcggtcttc cagtagtgag tcataatggt 1560 gccactaaaa gtatcattga ctatacctta gagaaagtca acgaagccaa agcttgcctc 1620 cagagcttga ctactgactc aaggagacag atcagcaata taaagaaaga gaagctacgt 1680 actttgatag atttggtcac cgatgataaa atgattgaga accacagcat acccactccg 1740 ttttcatgcc agttctgtaa agaaagcttc ccaggtccta tccccctgca tcagcatgaa 1800 cgctacctgt gtaaaatgaa tgaagagatc aaggcggtcc tgcaacctca cgaaaacata 1860 gtccccaaca aagctggggt gttcgttgac aataaagccc tcctcttgtc atctgtactt 1920 tctgagaaag gactgacaag cccgatcaac ccgtacaagg accacatgtc tgtactcaaa 1980 gcatactatg ctatgaatat ggaacccaac tctgatgaac tgctgaaaat ctccattgct 2040 gtgggccttc ctcaggagtt tgtgaaggaa tggtttgagc agagaaaagt ctaccagtac 2100 tccagttcca ggtcaccatc actggagagg aactccaagc ccttagctcc caacagcaac 2160 cccaccacaa aagactcttt gttacccagg tctcctgtaa aacctatgga ctcaatcacg 2220 tcaccatcta tagcagaact ccacaacagt gtcacgagtt gtgatcctcc tctcaggcta 2280 acaaaatctt cccacttcac caatactaaa gcagttgata aactggacca ctcaaggagt 2340 aacactcctt ctcctttaaa tctttcttcc acgtcttcta aaaactccca cagtagctcg 2400 tacactccaa atagcttctc ttccgaggag ctgcaggctg agccgttgga cctgtcatta 2460 ccaaaacaaa tgagagagcc caaaagtatt atagccacaa agaacaagac gaaagctact 2520 agcataagtt tagaccacaa cagtgtttct tcatcctctg aaaactcaga tgaacctctg 2580 aatttgactt ttatcaagaa agagttttca aattctaata acctggacaa taaaagcact 2640 aaccctgtgt tcggcatgaa cccatttagt gccaagcctt tatacacagc tcttccacca 2700 cagagcgcat ttccccctgc cactttcatg ccaccagtcc agaccagcat ccccgggcta 2760 cgaccatacc cagggctgga tcagatgagc ttcctaccac atatggccta tacctaccca 2820 acgggagcag ctacctttgc tgatatgcag caaaggagga aataccagcg gaaacaagga 2880 tttcagggag aattgcttga tggagcacaa gactacatgt cgggcctaga tgacttgaca 2940 gactccgatt cctgtctgtc tcgaaagaag ataaagaaga cagaaagtgg catgtatgca 3000 tgtgacttat gtgacaagac attccagaaa agcagttccc ttctgcgaca taaatacgaa 3060 cacacaggaa agagaccaca ccagtgtcag atttgtaaga aagcgttcaa acacaaacac 3120 caccttatcg agcactcgag gctgcactcg ggcgagaagc cctatcagtg tgacaaatgt 3180 ggcaagcgct tttcacactc gggctcctac tcgcagcaca tgaatcacag gtactcctac 3240 tgcaagcggg aggcggagga gcgggaagcg gccgagcgcg aggcacgaga gaaagggcac 3300 ttggaaccca ccgagctgct gatgaaccgg gcttacttgc agagcatcac ccctcagggg 3360 tactctgact cggaggagag ggagagcatg ccgagggatg gcgagagcga gaaggagcac 3420 gagaaggagg gcgaggaggg ctatgggaag ctgcggagaa gggacggcga cgaggaggaa 3480 gaggaggaag aggaagaaag tgaaaataaa agtatggata cggatcccga gacgatacgg 3540 gatgaggagg agactgggga tcactcaatg gatgacagtt cagaggatgg gaaaatggaa 3600 accaaatcag accacgagga agacaatatg gaagacggca tggaataa 3648 <210> 18 <211> 2519 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2519) <223> Btg2 <400> 18 agagcccgtg aggcggccgg accatcatcg tcctgctaat acagctactt cctcaaccac 60 cggtatgagc cacgggaaga gaaccgacat gctcccggag atcgccgccg ccgtaggttt 120 cctcaccagt ctcctgagga ctcggggctg cgtgagcgag cagagactca aggttttcag 180 tagggcgctc caggacgcac tgaccgatca ttacaaacac cactggtttc cagaaaagcc 240 atccaagggc tccggctatc gctgtatccg catcaaccac aagatggacc ccatcatcag 300 caaggtggcc agccagatcg gactcagcca gccccagctg caccagctcc tgcccagcga 360 gctgaccctg tgggtcgatc cctacgaagt gtcctaccgc atcggggaag atggatccat 420 ctgcgtgctg tatgaggagg cgccggtggc cacctcctac gggctcctca cctgcaagaa 480 ccagatgatg ctgggcagga gcagtccatc gaagaactac gtgatgactg tctccagcta 540 gagaggagcc gccccgccct ggcactctac tgttctcatg ctgccctgac aacaggccac 600 cgtatacctc aacctgggga actgtatttt taaagtgaag agctatttat acatgttatt 660 ttttttttta agaaaagagg aggaaaaaaa ccaaaagttt ttttttaaaa aaacaaaaaa 720 gaaaaaacaa ttcgttaacg ggagctgctt ggaagtggtc tccccaggtg cctttggaga 780 gaactgttct tgattgagtc tatgagccag tgtttgccta ggggagtggg ttggggattg 840 gcctagccaa ggtaaaaggg gattcttggc tgatccccca ggaggtggtg gaagggagca 900 aggttagcaa ctgtgaacga gaggggtcag ggtctgctct gggttaccgt tcccgctggg 960 atgcctgtat tcctggtccc tctcttactc aggggcattc aagcctggtc tcaaataata 1020 ctacattgcc taatcttctc ttttgttttt ctgctgagat cctgggcaca cggaaaggcc 1080 tctcctgtcc cttccgtctg agcagagttt cttgaaactg tgtctcgttt ctgatcctac 1140 cctcggggtc ctgaagaggt ggtttcccgg cctagaatct atctaaacgt ttttggaggg 1200 tgggctataa ggcagatata atggagggga accgcacaaa ccctttgctt tgctctgtgc 1260 tgctttgtat ggatggatgg ttaataactt agggatgatt tgcaatggaa ttttgggacc 1320 caaagagtat ccaatggggg tgggtgtttt ggacctaagc cctccttttg ggaaccacgt 1380 gacagtctga atgctgctac cattattcct ttgagaggtg gctcaaagct ccagggaact 1440 ccaggtcctt tcttactgcc ttctcttcaa gagcaacctc ccccatttct tttccctctt 1500 tcctgcggtt gggtcctgga gggccccatt tcctaggaca agagttctca atcactgtgc 1560 aatagtccca ggaagctctg gaactgggcc tcccagcccc tcctgattcc tggtgggttt 1620 taggaccccg ccttccccgt tcttctgact ggctggtggg ccttgaggag atctccctcg 1680 gccgcaggga gggcacctgt gcactgcagg actacctggt actcctgtgg ggctgccacg 1740 gagagccaaa ccttaggcat agctttgtct cctcggtgct cagagcacct gcagggggag 1800 gttgcccccc tcagtaaaaa tccaaattta tttgtagatg tgtgcaatat ttactgttct 1860 gggttggaga aaatcgggaa acactgggaa gaagtggcct tccttcaggt tcagtgacac 1920 tgatgagggc ttctcagaag gcctcgagtc tctcaaacca aaggacagag ctagagccag 1980 ccagtcaccc ttagtgagga tccccttccc catgtctctc cactgccgtg gcatcccatg 2040 tcctggattt ctcaattcct cagtttctac tcaaaggtgc tacttaccaa acactctgcc 2100 cgtcccgctc tccccagctt cgcacagccg tcccaggtgg cttcgtctct cctgctttaa 2160 agttaacttt gggcccacag acccgagagc tgtgggttga agcaaagctg tgaatcgctc 2220 cagatggtcc ctgtgttctg tccacacaca ggtccccgcc tttttagaag cagcctcctg 2280 gtctcatgct taaatctgtt cctcactgcc cgtgttcact ttagaaatgg cagaaccaca 2340 gagctggact gttgagcagg cctgtctctc tcattaaata gaaataagta agtttgtaag 2400 ctattccgac agaagagaca aaggttactg attgtacaat agcgctttta tatggaagac 2460 tgtacagctt tatggacaaa tgtaaaactt ttttgttttt aataaaaatg tagcagacc 2519 <210> 19 <211> 1473 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1473) <223> Rragd <400> 19 gggctgggct ccgtgccacc ccctcgctca ccaggagcgg ccccggggcg ctgcgggcca 60 ctcggcccac gcgggacctc ggaggcaagc gtgggcgtga tgagccaggt gctgggcaag 120 ccgcagccgc agggtgagga cggcggcgac gacgaggagg aggatgagct ggtggggctg 180 gcaggctacg aggatggacc ggagtcctcc gacgccgagc tggacagcgg accggaggag 240 ggagttctgg acttcagcga ccccttcagc actgaggtga agcccagaat tctgctcatg 300 ggtctcagga ggagtggcaa gtcgtccata cagaaagttg tctttcacaa aatgtccccg 360 agtgagacgc tgttcctgga gagtaccaac aggatctgcc gggaagacgt ctccaacagc 420 agctttgtca acttccagat ttgggacttc ccagggcaga ttgacttttt tgaccctaca 480 tttgactatg agatgatctt ccgagggaca ggagcactga tctttgtcat agactcccag 540 gatgactata tggaggcgct ggccaggctc catctcactg tgaccagggc ctacaaggtg 600 aacactgata tcaacttcga ggtgtttatt cataaagtgg acggtctgtc ggatgatcac 660 aaaatcgaaa cccaaagaga cattcaccag agggcaaacg atgaccttgc cgatgctggg 720 ttagagaaaa ttcacctgag cttttatctg acaagcatat acgatcattc aatattcgaa 780 gcctttagca aagtggttca gaaactgatc ccgcagctcc cgacgctgga gaatctgctg 840 aacatcttta tctcaaattc tggaattgaa aaagcatttc tatttgacgt ggtcagtaag 900 atttatattg caaccgacag cacgccggtg gatatgcaga cgtatgagct gtgctgcgac 960 atgattgatg tggtgattga catctcttgt atttatggcc tcaaagaaga tggagcgggc 1020 gccccgtatg acaaggactc gacagccatt ataaaactga ataatacaac ggttctttat 1080 ctaaaagagg tcacgaagtt cttggcgctc gtttgctttg tcagagagga aagctttgaa 1140 agaaaaggcc ttattgatta taatttccac tgcttccgga aggccatcca tgaagtcttc 1200 gaggtgagga tgaagatggt gaaatctcgg aaggcccaga gtcggttacc caagaagact 1260 ggagctactc ccaatgggac tcctcgggtg ctgctgtaag gggagccgtc aggagccaga 1320 gcccagacct cagtgaggag gctgttaaac taaactggac tgcaggaagg ctgagccctg 1380 actcagacat attaaggaaa aagaaaactt acccttttta aaataaaata agcactttga 1440 agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1473 <210> 20 <211> 1982 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1982) <223> Terf2 <400> 20 acggcccggc ggggagggcg ctcggcggtc gaacacgatg gcgggaggag gcgggagcag 60 cgacaacggc gggagggcgg cgaaccggcg agcatcgcgc agcggcggga gggctcgacg 120 ggggcggcac gagccggggc tgggaggcgc ggcagagcgg ggcgcggggg aagctcgtct 180 ggaggaggcg gtcaaccgct gggtgctcaa gttctacttc cacgaggcgc tgcgggcctt 240 tcggagtagc cggtaccggg acttcaggca gatccgggac atcatgcagg cgttgcttgt 300 caggcccttg gggaaggagc atacggtgtc ccggttgctg cgggttatgc agtgtctatc 360 gcgcattgaa gaaggagaaa atttagactg ttcctttgat atggaggccg agctcacacc 420 cctggagtca gctatcaatg tgctggagat gattaaaaca gagttcacac tgacagactc 480 aatggttgaa tccagcagga gactggtgaa ggaggctgct gtcattattt gtatcaaaaa 540 caaagaattt gaaaaggctt caaaaatttt gaaaaaatac atgtccaagg accccacaac 600 tcagaaagta agaactgatc tcctgaacat tatccgggaa aagaacttgg ctcaccctgt 660 tatccagaac ttttcctacg agatcttcca gcagaagatg ttgcgcttcc tggagagcca 720 cctggatgac acggagccct acctcctcac gatggctaaa aaagctttga gatcagaatc 780 agctgcttca agtacaatga aggaggaaaa gcacacagag ccagtggaga aaccactcag 840 agagcctcca cgacagcctc ggaaccctcc aaccaccatc ggactcagga cagtgaaggc 900 agctttcaaa gctctgtcta ctgcacaaga ctcagaagcg gcttttgcaa aactggacca 960 gaaagatctg gtacttccta acctagcatc cccatcatca ccgacccaca aaaacaagag 1020 acccaggaaa gatgaaaatg aaagctcagc tcctgctgag ggtgagggag gctcagaacg 1080 acagcccagg aacaatcgca tgacaataag cagattggtg ttggaggagg acagccagag 1140 ttctgagccc agcccagacc tcaattcctc ccggcaggcc ttatcagcat caccatccaa 1200 gcccagagct ctcaaccaac cccacacagg ggagaagaat cccaaagcat cgaaagacaa 1260 gtggaacagc cctaacgggc ttgaagaaaa ggaagtttgg tcggaagagg accagctgtt 1320 tgaagtgcgg gcaccaggtg aagacaagtc atccaattta gcaagaaagc agaagtggac 1380 catagaagaa agcgagtggg tgaaggatgg agtgcagaaa tacggggaag gaaactgggt 1440 tgccatttct aaaagttacc cctttgttaa ccgaacagct gtgatgatta aagatcgctg 1500 gcggaccatg aaaaaacttg gcttgaactg agaaaggttt tcagagccac aggactcaca 1560 agaacatgat tctcaacagt agtccctgag gctgtgatgt ctccttcaaa agctggagaa 1620 ttgcggcaac ctcctcctgt gctgggaggt ccggggacac tcctgtcact gttgatggag 1680 atcatggagc taagcggcaa agccaggtct acccatggct gcggcagagg cgcgggcagg 1740 cacatggctt gtacagtgcc ggaacatcat tagtgtttcc cttcagtggt ttgcttcagt 1800 ttgaatccct agtaacccag aagtcttcta agaaatgacg gaatccatta ggagcacata 1860 ggctctcatg acctgttaaa accagaaatg agagtcatcg ggaataaact taatcctcat 1920 tgagttttgg actctgactc aaatacaaag gaactccgtg tgttgaaccc agatgagaga 1980 tt 1982 <210> 21 <211> 1375 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1375) <223> Car6 <400> 21 ctgcattcag ggctacagca tctgccatga gggttctggt gagcgtggtg tccttgttct 60 tcctgggcat ccaggccctc agtgagtgga gctactcagg ggatgacggc ctggaagaga 120 gtcggtggcc tgagaagtac ccttcctgcg gcggggaaag gcagtcgccc atcgatgtga 180 agaggaggga ggtgcacttc agtagctcct tgttgcccct gcacatggtc aactatgagg 240 aggaggggct ggagctctct atgactaaca acggacacac agtacagatc accctgccga 300 acaccatgtc catgagagac tctgacggca ctgtgtacag gacaaagcag atgcactttc 360 actggggcgg tcgggactca gaaatcagtg gctctgagca caccatcgat gggatgaggc 420 acgccataga gattcacctt gttcacttca acgagaagta cgagacctac gagaaagccg 480 tggaccaacc agacggcttg gcggtgatgg cggtcttggt taaggttgag gattacacag 540 aaaacgatta ctacagcacc ttcatttctg agctggaaaa cgtcaagtat acaggacaaa 600 ccacgacact gagaaacgtt aacatccgga acatgttgcc cggggacatc agacactact 660 acacctacca aggctcgctc accactcccc cctgcacgga gaacgtcaag tggtttgtgt 720 ttcaggattc cgccaccatc tccaaggccc aggctgagag aatagagaat gcggtaatgg 780 atcaccacaa ccagaccatt cgaaatggtt accgcaggac gcagcccctc cacaacaggg 840 tggtggaagc caatttccca tactccccgg atgaagtctc taagaaccac ttttacatgc 900 acgagaagat ttcacacggt ttgaaactaa agaaaattaa gaagaagaga aaccacagcc 960 attgaaccgg aaatgagaca cagacaccaa gggctcaccc tgcccctttg ctaaggaatc 1020 ctggaatgtg ggtctccttg caacctgcag caaggagatc tctgactaac ccagagggag 1080 ttctcatccc tgagaggaag tggagctgcg tcagccagaa gagaagggat gtgggtgaga 1140 ccgaatggac ttggatggat gtacaaggaa tcagaccttc cataatcccc tgtcaatcat 1200 ccacctaaat ttggggtctg cggatgcagc tcatggtaga gaccttgtca tgacattgag 1260 tttgatcccc ggcaccagaa aaaaaagaaa atctttcact ttgatctacg ttataaatca 1320 ccccgaacct ccctttttaa tgtaataaag tgattttgga gattttcatt tttaa 1375 <210> 22 <211> 7500 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(7500) <223> Ptprj <400> 22 cggccgctcc gcgttaggag cgctaggctc cgccgtgtgg ccgccgccgc cgccgctgcc 60 atgtccccgg ggaagcccgg ggcgggcgga gcggggacta ggcggaccgg ctggcggaga 120 aggaggcgga ggcgtcggct ggaggcggag accagggcgc ccggcttcgg gcacacggcg 180 gggcgcgtcc cgggcacgtt ccagggcgcg cagggcatga agcccgcggc gcgggagacg 240 cggacacccc cgcgctcgcc cgggctccgc tgggcgctgc tgccgctgct gctgttgcta 300 cgccagggcc aggttgtgtg cgcaggtgcg gcgcccagtc ctgtatttga cgttgaagct 360 gtcaccagcc ctaccagtgt ggtattaacg tggaaacaca atgattcagc cacttcagaa 420 tataagataa atgagggaaa cacgctgcgg tatactgtta aaaaccagac atcatttaac 480 atcacaggct taagcccagc tacttcctac aaattctcca tcaccttggg aacagtcaat 540 gagacctcag gaaagcccac atacaaaaat atcacaacag agccctggcc agtgtcggat 600 ctccaagtcg cctacatcgg tgtgacacag gctcttctcg cctggagcaa tgcaaacggc 660 accgcttctt accggatgca gattgtagag ctgaccacaa attcatcagg tggtatttca 720 gatctgaagc cggggaccca taagagcttg gctgtccaag gatcgaatga gacccagcat 780 gacttatggg tcacagaagg cgtctcggat gccaatggca ccgagggaag cccagtggcc 840 aacatatccc aactacataa gaattctctt gcctctgcag acccaccctc tgcccgggat 900 ccctccctca cagaggtctt gctcactgag ctaaagcctg atactcagta caaagtcacc 960 atttattctc aagcagcaga tggcacagaa ggacagcctg ggaacaaagt gtttaaaaca 1020 aatcccatcc aagtttctga catccgagct gtgaacatca gtgactcgaa catgaccctg 1080 acctggaaaa gcaacaataa tgagtcccat gcttcattta cctacaaaat atacgtggct 1140 gggggttccg actccatcaa cgaaactgtc aatgagactc aggccgtcat ccgtggactc 1200 agctccagta ccttgtacaa catcacagtg cttcctttcc tgggtcagac cgcgggtata 1260 ccaggcttcc tccaagtgta cacttccccc cgtcctgttt ctgacttccg agtgacaaat 1320 gtcagcctga gggaaatcgg tttggcttgg agaagcaatg actcggagtc attcgagatt 1380 ttcatcacgc aggagggaag tgagaaacgt tggaatgctt cgacgggaga cctgagctat 1440 atcgttgaaa atttaaagcc tgggaccagt taccaatttg aaatattccc acgaggacca 1500 aatgggactg aagggccatc ccagacagtt gttggtagaa ctgactgcag tgctgtgact 1560 gacatccgcg tggtcagcgt tagcaccact gaaatacagc tggagtggca gaatacagac 1620 agtgcttctg gatacactta ccatttagtt ctagagtctg agaatggctc catcaagacc 1680 aacagttctc agaaatggat cacagtgggg ggccttaccc caggcacctt atacaatgtt 1740 acaatctttc cagaagtgga ccagatggag ggcaactcca gctctattac ccagtacaca 1800 aggcccagca atgtgtccta cattgaagta aacaccaaca ccaccgtggc agccatccag 1860 tggaagaacc tggacgcagc ctctgcttcc tactcctact ccgttcttat cttgaaggct 1920 ggagatggca gcaatgtaac cagcagggtc agagacatcc cttctgtcac catccctggg 1980 ctaatccccg gcgtctctta cgaagtgaag atctttacaa agattaggaa tacagaggtt 2040 gggaatgagg tacctggtca gaagctgttc tgtatggaac ctgcacaagt ggattcctta 2100 cactgtgaag tggtcccgaa ggagccagcg ctggttctga agtgggcctg cccccctggc 2160 atgaactcag gctttgaact gggggtcagg agtgatgctt gggacaatat gacacacttg 2220 gagaactgca ctttggacaa tgacacagag tgcaggacag aagtcaccta tttgaatttt 2280 tctacctcgt acaacatcag cattgccacc ttgtcatgtg gaaagatggc attgcccacc 2340 cagagcacct gcaccactgg catcacagac ccacctcctc cagatggatc ccctaatatt 2400 acatcggtca gtcacaattc agtaaaggtg aagttcagtg gttttgaagc cagccatgga 2460 cctatcaaag cctatgctgt ccttctcacc acaggggaag ctggccaacc ctccacagat 2520 gttttgaagt acacatatga agatttcaaa aagggagcct ccgatactta tgtgacatac 2580 ctcataagga tagaagagaa gggacagtct cagggcttgt ctgaagcatt gaactatgag 2640 attgatgtgg ggaaccaatc cactaccctc ggctactaca acgggaggct agagcctctg 2700 ggctcctacc gggcttgcgt tgctggcttt accaatatta cctacaacct tcagaacgat 2760 ggccttatta atggggatga gagctatgta tctttcagtc cgtattcaga ggccgtgtcc 2820 ttgcctcaag atccaggtgt catctgcgga gcggtgttcg gatgtatctt tggtgccctg 2880 gccattgtgg ctgtgggagg cttcatcttc tggagaaaga aaaggaaaga tgccaagaat 2940 aatgaagtgt ccttttctca aattaaatcc aagttaatcc gagtggagaa ttttgaggcc 3000 tactttaaga aacagcaagc cgactccaac tgtgggtttg cagaggaata tgaggatctg 3060 aagctgattg gaataagttt acctaaatat gcagcggaaa tagctgaaaa cagggggaag 3120 aaccgctaca acaacgtcct gccctatgat atttctcgag tcaaactttc agtccagacc 3180 cattcgacag acgactacat caatgccaac tatatgcctg gctaccattc caagaaagat 3240 ttcattgcca cacaaggacc tttacccaac actttgaaag atttttggcg tatggtttgg 3300 gagaaaaacg tatatgccat tgttatgctg accaaatgtg tggagcaggg aaggaccaaa 3360 tgtgaagagt actggccttc caagcaggct caggactacg gggacataac tgtggcaatg 3420 acatcagaag ttgttcttcc ggaatggacc atcagagatt ttgtggtgaa aaatatgcag 3480 agtagtgaga gtcatcctct gcggcagttc catttcacct cctggcctga ccatggtgtt 3540 cctgacacca ccgacctgct catcaacttt cggtacctgg tccgggatta catgaagcag 3600 atcccccctg agtcaccaat cctggtgcat tgcagtgctg gggttggaag gacgggcact 3660 ttcattgcta ttgatcgcct gatctatcag atagagaacg agaacaccgt ggatgtgtat 3720 ggcattgtct acgatcttcg gatgcacagg cctctgatgg tacagacaga ggaccagtat 3780 gttttcctca atcagtgtgt gttggatatt atcagagccc agaaagactc aaaagttgac 3840 ctcatctatc agaacacaac cgcaatgaca atctatgaaa acctcgagcc agtgagcatg 3900 tttggaaaga ctaatggtta catcgcctag ttccaaagca aacccttctg aagctaacca 3960 gaccgtcaca cccacagtga aggagaacgc cctgacgggg acatgtttta tgtgtctcat 4020 ttctcaattc tttgttctgt tctgttagaa ctacttggag ggcatggggc tgtgcatgta 4080 aaacatggca gataggcagt tggggctctc aggggctgtg ggcaggtggt gtgtaaatca 4140 gctgcattcc tgattaccaa tgggatgggt tcgctttctg tttttctttc cttgagaatt 4200 gtggaaaacc aggaaaagtg agctatgttt ttgttttcca agcaggtttg ttctcctctc 4260 tttctattcc tcccccttct ctctctccct cccctgcctc tctctgtttt tttttaagac 4320 ttttatatga ttcacatgct aaagccagga ttatgttggg ttggatatat tttaagtatc 4380 agaggtctat ttttacctac tgtatctcgg aatctagccg atggaaaagc atggctgtgg 4440 gtgtttctca tgcagggagg ggcacccggt gcctcttctg cgtgggtttc tatttgaaca 4500 tgtgcctttt ctgaattatg cttccacggg caaaactcag tagatatctc tatttttata 4560 ttgaatctca gaattggaat atacagaata tttaaacagt agcttagtat cagaggttcg 4620 cctcctcagt aacattcctg tcccatccca ttagaggagg ctttctctgc ggcccgccct 4680 tgacacacat ttgtgctcca tgttcctttt ccttcctttc tttttttttt tctcccctcc 4740 cagttttcgc caaagaactt ctgttggtga gattttcatc ccattggttg ggtgagaata 4800 gaagtttaaa atatcaccat gagactctct gtgggtggga gtggggagga acagaggaat 4860 caacatacca tggtgtgtgc accccttttc atcccatctc ctatgttctc tcatttctgt 4920 ctttggtaag aaggattttt ttaaaggtgc aatatgtgac gtagtggttc acgatgctct 4980 gggttcttag taatgtttta ctcaggttgt catttatgtg tgtatgtgtg tgtgtgtgtg 5040 tgtgtgtgtg tatgtatgta tgtatgtgtg ttttatagcg tggtgatctg tgaacatttc 5100 agtgtgaact cagattaacc cctttccccc caaagtccac tggctttagt ctctctgcag 5160 tgacacacat cagtatctac tgtatatata aatactaaac tcttacacac cagtcattcc 5220 tatgaattga ggtgtacaaa gtttgatttg tatcaaagat gtaattatta tttttaaaac 5280 ctctttcact acactgctgc tgtaattact ttgaattttt aaagaaaaat gtagattttt 5340 tttgttttgt ttttggcttc aggtgtgtat tcaccaagag tttcagaatt tatgtggttt 5400 tattttattg gtacataatc tgcaaacttc tcaaggcatt aacatgacaa gatttgtatc 5460 tcttattttt atcttgtggc tcaggttata tttgaagaag tttcaagttt attttctagt 5520 aggcagtgaa gtatacataa ggtcaatgaa ggaatcacca ggtccctgga gtcctgtggc 5580 tgttttccac agttacacat cctgctgtat gtttgggacc atgggtattg tgttgaagat 5640 gagggcaggg gtcttctccg aggacctggc cactgtgagc cctggggtaa cctgtcctct 5700 gatgttctgc actctgttcc tcgagtcacc ggcactttga tggctgactg gacctgatca 5760 tgagtgtttg tagggttaga gaggctgaac catgatgtac tgaaagccct cgctgtggtt 5820 cagcactgta gtgtgcgatt cttgctgtga cccagcgctg ctgtagcact gttgctgccg 5880 tggctcggcg ctggggcaca acccctttcc ctttgcggta ctgaaaggat tgaaagaaga 5940 ggtcatggcg ctgtcatgct ctgggggaga attttacttc tcacatggaa actgcacttt 6000 ttgctaaatc ctttgcattt tgatgttcac ttagtgtcca gccctttagg atgggctggc 6060 cagggtaggt tggccccctg gactcaactt cactggggaa cttgacgctg cagttgtgaa 6120 tcagggaagc catgctgtct ccaggtatgg ggtgaagctg aacatgggct cattatttcc 6180 aaatgccctg tctggtctgc tcactaggat gtgctgactt tgggcactat acagaggggc 6240 ctgttctggc agtagttctg tgcaccgcct atacacctca gtctgtcagg aacggttgta 6300 gtgggtggta aggggtccaa tcccacgcag cgcctatgcc ctgcctctgc tgccatggaa 6360 agtgcgagga aaggacccgc ccctaaaaca gccctgtaga agattagagt ccctcaaaaa 6420 aaaaaaagca acagaatcat gaacacatca tatacaattg caaaacacag aaaccttctc 6480 cactcctacc tgtatgggtc tagaaagtca ttaggcatca gccccagcaa gccattccca 6540 gtcccaagag gaaggctagt gacaggtctg gagttccaaa tgggcaggtc acaagaagct 6600 caccatgcca ttctacatcc ggaggaggac tgcgtggtgg agtttgcata gcaaagccat 6660 tggaaaggga aaattgacaa cagagggtaa ggttgggcag agagaggggg aaggtccttc 6720 tcactgtttg ccccaagccc tcagtggaac tgtgaatgaa agttggagga gtctggtgaa 6780 atcggaatga tggaactccc tgctcagatc cgatggcagc accgagaaaa gcagccagtg 6840 tggggtgtgg tcagtgaaag ggctacagac tggtggccaa ctgctttgaa ggacttaggc 6900 cattgactga tgacttctaa ggagaaagat ttttccacca gagctgaatc tagcaacaat 6960 tggcaccact gggtgtctgt tctctgaggc cattttgcca tctccagcca gactttggca 7020 caatggacct gctggctttg tgctttgtga agttggaggc tctggggggt gggagtgggg 7080 aggagtgggg gagggtcaac tatgcagttg gttcattcat acttgttttc tgggatggag 7140 aagcctgggt tttttgtttg tttgtttgtt tttttgcaat gcttgattgc ggcttgttga 7200 gctaaacaag cctggagact gaagctgatt cacctcaaaa caaagttgga attctgcatt 7260 ttccagattg ctgtgtagca actgtgtatt caacacctgt agctttttct ccctggggca 7320 cagaatagaa gttgatgtgg actctaaact gtacttttct tgtaactatt ttggaatgat 7380 gcacatttct aatgtctgtt gtacttgtac agagtattga tgtaggttgc tttttttttt 7440 taaaggaaaa atggcctgaa aaactttttt taaagactta caaataccaa atataaaata 7500 7500 <210> 23 <211> 628 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(628) <223> RT1-EC2 <400> 23 gagctactgc gcccagatcc cccaaaggca catgtgaccc ttcaccccag acctgaaggt 60 gatgtcaccc tgaggtgctg ggccctgggc ttctaccctg ctgacatcac cctgacctgg 120 cagttgaatg gggaggacct gacccaggac atggagcttg tggagaccag gcctgcaggg 180 gatggaacct tccagaagtg ggaagctgtg gtggtgcctc ttgggaagga acagaattac 240 acatgccttg tggagcatga ggggctgcct gagccgctta ccctgagatg gagtaaggag 300 ggagccttct atagaccctg agctggtcag ggctgagagc tggggtcatg aaatgaaatg 360 aaatggttct ctggggcaaa ttaatctgta gctcagttca caagaaccag caatggctgg 420 tcagttcaga agaaacaagg aggctgagct gtttgctgtg tagtagttcc tgggggcaac 480 tccaatctct aattgacagt acagcagcaa tccaggtcag tagtgtcagg atagcaaaca 540 ggaatcatca gcggtggcac aaaccagcag aaactgccag gcatccacca aatcagcatg 600 agtcagcagg actgagcagg gaagcctg 628 <210> 24 <211> 2682 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2682) <223> RT1-S3 <400> 24 aaacacaacc cacattcatg tttttcacag tccctgggca tgaggatgtt acctcctgcc 60 tatttgctcc aactactggc aggcaccatg gtcctgaccc agactagctc acactcgctg 120 cggtatttct acaccgccct gtcccggccc ggcctcgggg agcccaggtt cattgtcgtt 180 ggctacgtgg acgacacgca gttcgtgcgc tatgacagcg atgtggagaa tccgaggatg 240 gagccacggg cgcggtggat ggagcaggag gagccggcat attgggagcg ggagactcgg 300 aaagccaggg acaccgggag gaacttcaaa gtgaatctga ggaccctgct ccgctactac 360 aatcagagtg acgacgaatc tcacacgctg cagtggatgt acggctgcga cgtggggccc 420 gatgggcacc tgctccgcgg ttattgtcag gaggcttatg acggccggga ttatatctcc 480 ttgaacgagg acctgcgctc ctggaccgcg actgacatgg cctcacaggc ctctaagatc 540 aagtcagagg aagttggtga ggcccatcac cagagggcct acctgcaagg tccttgcgtg 600 gagtggctcc acacatacct acatctggga aaggagacgc tgctgcgctc agacccccca 660 aaggcacatg tgacccttca ccccagacct gaaggtgatg tcaccctgag gtgctgggcc 720 ctgggcttct accctgctga catcaccttg acctggcaat tgaatgggga ggacctgacc 780 caggacatgg agcttgtgga gaccaggcct gcaggggatg gaaccttcca gaagtgggca 840 gctgtggtag tgccttctgg ggaggagctg aagtacacat gccatgtgga gcatgaggga 900 ctgcctgaac ctctcgccct gagatgggag ccttctccat tcaccgactc cagcatgcca 960 gtgattgttg tccttggagc tgtggccatc attggagctg tggccatcat tggagctgtg 1020 gccatcattg gagctgttgt gaggaggagg aagagaaaca caggtgaaaa aggcagctat 1080 gctcatgttc taggcagcaa ggctttccag atctctgact ggcctcagaa ggcatgaaaa 1140 gacagttgcc tcgtggggct gagcgacaag ttctgactaa acatctgagg gagctgcttc 1200 ccctgaggac aatgtgaaga actggcaatc ccagaccttc ttgcctccct ggacacctga 1260 cttcacaaca gaaaataatc tgactctggg ctgggtgttt cctattgctt ttatctgcac 1320 tgagtggaaa tgcggtttcc aacagtgtaa cgcagtaccg ttgtgtggtg gtagtgacat 1380 tgcacacagg tttgtgagct gggggtgtga tgtgcttttg ttactgtagg cagaacaagc 1440 tagaagtcca ccattcctct tatggtcatt gttttaaaac aaaacaaatg ctggagagat 1500 ggctcagtgt taagagcact gacttctctt acagaggtcc tggttcaaat cccagcaacc 1560 acatggtggc tcacaaccat atgtaatgag atctgatgct ctcttctgat gtgtctgaac 1620 acagctatat atgataaata aatctaaaaa atatttttta aatgaatagg gcacaccatg 1680 gtcaactctg ctgtctgttt atctctagac atccagtgtc tttagagtcc acacaaggtc 1740 attaaaagga ctggggtgga tggtgactgg agagatagct cagtggttaa gagtgtttgc 1800 tgcttcatgg gtggtggtgg tggcacaagc ctttaatcca aacactcagg aggcagaggc 1860 aggtggatct ctgagttcaa ggccagcctg gcctataagg caagttccaa gatagccaag 1920 gatacacaga gaaaccctgt ttgaaaaaac ccaagcctag acctagagag ttggctcaat 1980 ggttaagagc actgactgct tttccagagg tcctgagttc aaggcccagc aaaggcacat 2040 ggtggctcac aaccatctgt aatgggatct gatgcacttt tctggtgtgt ctaaagcgac 2100 atggtaactc gctgtctgta actagtagca aacagttcat atctcacaca gacatgaatg 2160 cagatagagc accaacacat ataaaattaa atctttaaaa aatgaaaggt ctgggggctg 2220 gatgaatggt gtttgtcttt gcaaatgtct gacagtggct gtgactcaca gcctcatagc 2280 agctcctatt gcctggtgtt caccatctgt cttggttata aaaaggtttc gtaatgtgaa 2340 acccttcaaa tgagctggtg cccttctcac cagtttgcat cttacaggat tcctgaaggg 2400 cttatattct gggccgtccc attgtggagg attaggtttt acacaacgta tccactctag 2460 cattgcaatt tccctgagcc ttaaaatccc ttcatcgacg ctgagccaag ggatatctgg 2520 catctgcaac tccttttccg taggccgtca tttgatgaac gcttcagcca accattcaaa 2580 caaacttctg acactttttt ttaactgtgt ggccttccat attaaaccta gaatctccac 2640 tcagagagac catgtcaata aattcagcct gatctatttt aa 2682 <210> 25 <211> 2107 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2107) <223> Vof16 <400> 25 gctgaaggaa ctttttgtct tttaaggaag gaaggaagga aggaaggaag gaaggaagaa 60 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa aggaaggaag gaagaaagaa 120 aagtttgtcc gagtgatggg aatacacctc tgaggcttcc attgttaggt gggatcaggt 180 gaccagagtg tggcagctcc tggattctgt gaaagtaggc acaggatgtt agcatcccat 240 gttcactgct atggatgcct gtgtatatgg ctaatacgga ggctgctgga tctattcctt 300 gagagcaaca cacagtacta tcggagcgta ataccaacag ctcagtgcct ggtgcttggc 360 ctcagaacat ctcagctgaa gtcccagcat gccccatgcc tccaactttt aagctcaaca 420 gttaatctca aaattgtgcc caattaaaat gggcaggaga atgtatttcc ctctgcattg 480 tctacacgtg tgttctatgt gactaggttt tcctgacgta gttcctcgaa caccactagt 540 ctggactaaa tggagaggtt aaatattcaa ctcttaatat tcaatacaaa aggagggaat 600 caagagatca ggaaagataa aatatgtgtt actttgcaag attttgtgag aacaaaaaaa 660 aaatggaagg aagagttctc cctccttggt ttggtacctc tttaaaaatg ttatacacaa 720 tgggttttta aatgaaggag atagatatat attttctaaa tattatggaa tgaaagaagc 780 aactgggcac atttggtatt agcgcattct tggggcggag aggggggggt caatcaatgt 840 ccatgacttt gctttagaaa ttagaaagat tgctatcagg attttaattc accccgacaa 900 agttattggt catagcaaac caaatttcaa aatgatcctc tctcagggca attgttagca 960 ttttccccac tttgtagttt tctgagattg taacttttca cggcagggta gctgcagtgt 1020 ctcaggtctg cctcacatag gagagaagga ctgggaggct tacctttcct ttgttgtaga 1080 aaactccggg cgcacggttc cctttaaaca gtttcactct tctcagccca acctttctct 1140 ccatttttgg aaaataccta aatcaaccca gacacccaac accttcatct ctgaaagatt 1200 ttggaatggc ttgtagtctc attgtgacac ggagtgaaag gtgaaggaaa cggttgccta 1260 ttttttaagc attccttgca attttactca ttttactcca aactgcagtc aaggaagcat 1320 tttttttttt tttgcaccag cacgctgagc tgagaagtgt acaacaactg tactatgtct 1380 tttgttgaag cctcccgtgc ggctgtaatt taactgttac ttggcaccac ttggtagaag 1440 acgcttcaaa gcgtacagtt ctgtaagagg ttgcccgcga gtttatataa agtaattaat 1500 gattccccac cccagcccag ccaatgtgta tgtatggcta tgtggaaatg atggcggtac 1560 atcagcttaa cttatgggta atatatattt acatcatgca tttgatagaa tggcagacat 1620 tcggtgcttt tgaaggcaag atatgtacac agcctaatag aagaaacgtg ggcaggatca 1680 ataaagctag gatagctgta atttctctgt gatttcgaat gatcgggcaa cgccatacaa 1740 atgcttctgt ttgtactctg agtccctatg ctttcgagtg gattcctcct gtttctcgga 1800 tgtaaaaccg ggcgcccagg cattcagagt gcctgtgaca cccaggtttt tatatattag 1860 caggcaactt cttcatcaca agggcaggtt tctcaacact cccctcttcc tcgtggagcc 1920 catcagcgaa gttcagtgaa atgaataaca taattggtgg ttggttcaat cactaccagt 1980 ctagactagc ccagacgcat caattagagg ggactgtctt ttagagggag agtgtaaccg 2040 aaacaagcag ggtattattg atactgatct ttaaaagcga aaatccagcc tggcagataa 2100 aaaaaaa 2107 <210> 26 <211> 4050 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(4050) <223> Homer1 <400> 26 ctgaagctgg cttttgcgtt tttctacacg tacactaatt ttatggaata gttaaagtgc 60 tatattctcc gcgcaacctt ttcaaattcc aaatgtttga acgttttggt gtcagcgcga 120 gtgaaatcat tttaccgaca agaactaact gaattgtctg cctcgttgag ttgcctccgg 180 aaaagatctc gggggtggaa aagcaactgc aaaataacag acggagaaaa ttccttggaa 240 gttatttctg tagcataaga gcagaaactt aagagcaagt tttcattggg caaaatgggg 300 gaacaaccta tcttcagcac tcgagctcat gtcttccaga tcgacccaaa cacaaagaag 360 aactgggtac ccaccagcaa gcatgcagtt actgtgtctt atttctatga cagcacaagg 420 aatgtgtata ggataatcag tctagacggc tcaaaggcaa taataaatag caccatcact 480 ccaaacatga catttactaa aacatctcaa aagtttggcc aatgggctga tagccgggca 540 aacactgttt atggactggg attctcctct gagcatcatc tctcaaaatt tgcagaaaag 600 tttcaggaat ttaaagaagc tgctcggctg gcaaaggaga agtcgcagga gaagatggaa 660 ctgaccagta ccccttcaca ggaatcagca ggaggagatc ttcagtctcc tttaacacca 720 gaaagtatca atgggacaga tgatgagaga acacccgatg tgacacagaa ctcagagcca 780 agggctgagc cagctcagaa tgcattgcca ttttcacata gtgccgggga tcgaacccag 840 ggcctctctc atgctagttc agccatcagc aaacactggg aggctgaact agccacgctc 900 aaggggaaca atgccaagct caccgcagcg ctgctggagt ccactgccaa cgtgaagcag 960 tggaagcaac agctggctgc ctaccaggag gaggcagagc ggctgcacaa gcgggtcacg 1020 gagctggaat gtgttagtag tcaagcaaac gcggtgcaca gccacaagac agagctgagt 1080 cagacagtgc aggagctgga agagacccta aaagtaaagg aagaggaaat agaaagatta 1140 aaacaagaaa ttgataacgc cagagaactt caagaacaga gggactcttt gactcagaaa 1200 ctacaggaag ttgagattcg aaataaagac ctggaggggc agctgtcgga gctggagcag 1260 cgcctggaga agagccagag cgagcaggac gctttccgca gtaacctgaa gactctccta 1320 gagattctgg acgggaaaat atttgaacta acagaattgc gggataattt ggccaagcta 1380 ctagaatgca gctaaagaaa gtgaaatttc agtgccaata gatgaagaga tactgtctgt 1440 cttcgtagga ctgtttgggc tctgtaccaa gattgcacaa aattttttga atatcattcc 1500 tccagaagga gggtgttttg aaaattggaa ttgtatattt cagtataaat tttagaattt 1560 agcttatagc tagttggggg aaaaaagaca tgaaaaactt gaaccacaaa ttacctccat 1620 gtacattggc catagttaac cagaaagtta taagtagaca cttaatgcaa tcttttcccc 1680 tgatagtagc caatgggaga attaacaatg tctgggtccc ttctcctttt tctgttcaac 1740 acagtgaaga ttatctgctt tttaaattta tttacgatat ctacagctgt gttttgtgta 1800 aaaacttagt aatggaagcc ctgtctttgt tgttatctga ataatttctc aggatatttt 1860 tttgctgctg agaaagggcc attaccaatt aatccttgcc aggagttggg gagctatgtc 1920 tctaattgga atcactataa ctgggtgtct ggagttcttc ccttttcgta ctgagagtgt 1980 tctcactcta gtgactcctc tggtacactc cgtgttctcc aatcttgtct gttgtacttt 2040 acttttccat attgactcca tgtatttatg agaagatatt atctcccatt ttattataca 2100 ttttgaagcc aactaaacaa aggcagctga gtccttcaga tatttttctt tttaaattta 2160 tagtaaattt gacacagaac tgaaattcag cagtccgtct ttgacggttt agtctagcaa 2220 tgttaaggat atttagagaa aatatgcagt tacgtttatt tatatatttg gcaagaaatt 2280 ttttctggat gatcaatgct tttcaattta tgataaataa tggttagggg gcgctgttta 2340 ttatagataa ttttaaggta tatagctgtt ttcaaggagg tccacttccg tctagcagcc 2400 aagcagagga ctgtatctaa atcgtgatcg tggcagatgg gtcttcatag aaaccatgtc 2460 tttattcaaa cttcataggg caatattttg aactgttacc taggcatttc aaaacaggaa 2520 ataccgtcaa cagactcttc tccaagagca ggttttactg ttgttttgat gtaattttaa 2580 gacatttagc aaacatgcat ttctttatat gatacatttc tttcacaaaa caatttaaaa 2640 gtaagccacg tgctgtctgc tctgcccggg taggaattgc atcagaatac atatatcttg 2700 ctgtacaatg cctgtgatat tgaagagggt tcttttcatg tatgcttgag tatctaactc 2760 tggagtcaat gaatgcactg actttttttt ttgttcgtac cccaaatgat tgaattgtta 2820 agtacaaatt aagcagatta actcattttt tcactcataa acagattctt agtactagtt 2880 ttgttttata tttatgtgta tgtatgtaaa tacatacata ttaatttata ttagagtgaa 2940 aaataaattg tttgtttcta acattagttt ctacagtaag gtgtctctga aacatgtgtg 3000 tcagacactt agccaccatg cattctatgt gctaccccat catgccagtc acctccatcg 3060 acgttagggt attttcctta cctgtctatt ataaagagaa taacttaggt acacatgctc 3120 agagccgaga tatttctctg ataaatcagg taataaaatc tatttgatgg gtagaatttt 3180 gaaaacagac atgattttat ctatgagttt ctgaatatca aagaacacca ggttttcatt 3240 taaatagagg tctaacacta gggatcaggg aatttagtta tgaagagttt aaaaaaaaaa 3300 tctaaaaaag taaaaaaaaa acagtataag ctgttgataa ggtaagcaaa ttattttaat 3360 gatgtaataa aatattttta aattttggca tagtgatcat ttaatgggaa aatactcacc 3420 aaaatgtctc cacttgaatt gtactgataa tgtgaggcat atgtgtaact caatatatac 3480 atatacctat atgtatatac agaaattatt tttaatattt tcctactgct gtgaaattta 3540 aaattggaaa attttgtgag tgttttccat gtccaataga gcctaactgt ttctttttta 3600 gtaacttaac aatctcttga gggctgcacc tataaagtcc cagcttgtca gtagacatgt 3660 acagtgtttg ggataaggtg gacacagtgc acatatgagt aagaccttcc tgactatttt 3720 aaacatcact cacatgagga gagcctctat gctataggtt gtgtgcctac tgtagctttt 3780 ccatcgctgt attatataga catttgcata ttaaaatttg attttcccag agataaatat 3840 tatatagtgt atctatattt agatcaaact gtggtaacat gttgatgaga tcatagcgtt 3900 ggggaatgta gcctgaacgt gtggactcgc agagaccccg agggagagca ggggtcaatc 3960 ccatctgtgt ataagttatt ataactatga aatcttgtac aaaagcaaaa actggaaaaa 4020 aaaacaaaaa tacagttttt attttgaaat 4050 <210> 27 <211> 2130 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2130) <223> Nmnat1 <400> 27 gtctcctgga ggactagggc cgtttggcct tcacggcctg acaacaacat cggcatcaga 60 ggactccatt tagatcagca actgcaactt ctccccatgg actcatccaa gaagacagag 120 gtggttctcc tggcctgtgg ttcttttaac ccaatcacca acatgcacct caggctgttt 180 gagctggcca aggactatct gaacgctaca ggagaataca aagttatcaa aggcatcatc 240 tcaccagtcg gtgatgcata caagaagaaa ggactcatcc cagcccacca ccgaatcatc 300 atggcggaac ttgccaccaa gaattcacac tgggtggaag tagacacatg ggaaagcctt 360 cagaaggaat gggtggagac cgtgaaggtg ctcagacacc atcaggagaa gctggcaact 420 ggcagccgca gtcacccgca aagctcacct gtgctggaaa ggcctgggcg gaagaggaag 480 tgggctgatc aaaagcaaga ttctagccca cagaagcccc aagaacccaa accaacaggt 540 gtgcccaggg tgaaattgct gtgtggcgca gacttgctgg agtccttcag cgtccccaac 600 ttgtggaaga tggaggacat cacgcaaatc gtggccaact ttgggctcat ctgtgtcact 660 cgggctggca gtgacgctca gaaattcatc tacgagtccg acgtgctgtg gcgacaccag 720 agcaacatcc acctggtgac cgagtggatc accaatgaca tctcatccac caagatccgc 780 cgagcgctca ggaggggcca gagcatccgc tacttggtgc cggacctcgt ccaagagtac 840 attgaggagc atgatctgta caactctgag agcgaagacc ggaatgccgg ggtcaccctg 900 gcacctctac agaggaacac ctcggaggcc aaacacaacc attccacccg atgacacccc 960 gcaacgtccg atgatcctct ccaggcccaa aacaattggt gttagtaact cagggaagga 1020 cttgccatcc tgttttataa actgaaattt aaaggtttga ttaaaaaaac caacagggaa 1080 ttaagatcag ttactgagat gaatgttcta aataagacca tataagaaag aatgtaatac 1140 acctttaaaa taacagctca ttcactaaaa tgagatgtca atgatgccct ctctaaatac 1200 attttttcaa gaaaggaccc tgtgctgtgc tctaccacac aagaggccgg agacatagtt 1260 ccgaggttaa gagcacagac tgcccttcca gagcattcag attcagctcc cagcacctgc 1320 aaggcagctc acaactgtct gtaactccag tcccagggga tccgatgccc tctctgtccc 1380 ctatgggctg taggccacaa atggtgcata gacagacata caggcaaaag atacatacat 1440 acacacactc acagatacac gcacagatac acacagacac aaaaacacac acgcacagat 1500 acgcatacat acacatacat acacacacac atacacacat acatacatac acacatacac 1560 gtattcacac acacacacac acacacacac acacacacac acacacacac acacacaaag 1620 aagaacctca ctttaaccag actcagtgat ggccacctac agccccagct gcaccaggag 1680 ttgacgtagg agaatcactt tgaacccagg agtctgagat gactctagac aacatggacc 1740 ctttctgaaa acaaaaacaa aacagaatcc tagctctagt tatgaagaga gctgtccatg 1800 gctggcgccg gccatcttta tccagagtag aaggaaggaa ttctttacga cgtgaccttg 1860 gctgggcatg cagctcggtc ggtagagcat tggcccgcag gcccgaggcc ctgggttaga 1920 tccccagagc cacatcgact gggcacggca gtgcacacct gtgatcctgg cactcgggag 1980 attgaagcag aaggatcaaa agctcgaggt catccttgac aaccagcaag tttgaggccg 2040 tcaagagatg ccaaagaccc cttctctaaa ttaaacaaat aaataaatga ctctgtaaaa 2100 tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa 2130 <210> 28 <211> 2623 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2623) <223> Mx2 <400> 28 cccaggagct ttctctctgg gaaggggtgg agacagctgt ttaaagacac tgcaaccaga 60 aagccaagca ttctgtcact aagcaggaga ctgagtgccc acttggaaga agaaataaaa 120 gatggttctt agcacagagg aaaacaggag tgttgattta gtcaacttac ccagtgtccc 180 actgcccgat ggagaggctg gcgtagggga gaacaacaag gattccttga acaacctctg 240 cagtcagtat gaggagaagg tgcggccctg cattgacctc atcgactccc tgcgagctct 300 gggtgtggag caagacctgg ccctgcctgc catcgctgtc atcggggacc agagttcagg 360 gaagagctct gtgctggaag cactgtctgg agtggccctc cccagaggca gtggtattgt 420 caccagatgt cccctggtgc tgaaattgaa gaagctgaat cagggagagg agtggaaagg 480 caaagtcacc tatgatgaca tcgaagtgga gctctctgat ccttcagagg tggaagaggc 540 catcaacaca ggtcagaacc atattgctgg ggtagggctg gggatcagtg ataaactcat 600 tagcctggat gtcagctccc cacacgtccc agacctgact ctgattgacc ttcctggaat 660 caccagggtg gctgtaggca accagcctgc agacatagga cggcagatca agagacttat 720 cactaactac atccaaaaac aagagaccat caacctggtg gtggtcccca gcaatgtgga 780 cattgccacc acagaggccc tgagcatggc tcagaaggtg gaccctgatg gggataggac 840 catagggatc ttgaccaagc ctgatctggt ggacagaggg actgaagaca aggtcgtgga 900 tgtggtgagg aacctcgtgt gccacctgaa gaagggctac atgatagtca agtgcagggg 960 tcagcaggac atccaggagc agctgagcct ggctgaggct cttcagaagg agcaagtctt 1020 cttcaaggaa caccctcaat tcagagctct tctggaggat gggaaggcca cagtgccctg 1080 cctggcagag aggctgacca tggagctcat ctcacacatc tgtaaatctc ttcctttgtt 1140 agaaaatcaa ataaaggaaa gtcaccagag tacaagtgag gagctgcaga agtatggtgc 1200 agacatacca gaagatgaga atgaaaaaac tctcttcctg attgaaaaaa tcaatgcttt 1260 taaccaggac atcactgcca tagtagaagg ggaagagatt gtgagggaga aagaatgtcg 1320 cctattcacc aagctccgta aagagttctt cttgtggagt gaggagatcg aaaggaattt 1380 ccaaaaaggt tctgatgctt tatataaaga agtctacaca ttcgaaatgc agtatcgtgg 1440 ccgagaacta ccagggtttg tgaattacaa aacatttgag aacatcataa gaagacaaat 1500 caaaaccctg gaagaaccag ctatggaaat gcttcacaag gtcactgaaa ttgtacgggc 1560 tgcctttaca acggtttctg agaaaaattt ctctgagttt tttaatctcc acagaactac 1620 caagtccaaa cttgaagaca tcagattaga acaggaaacg gaagcagaga aggcgatccg 1680 gcttcacttc cagatggaac aaatcatcta ctgccaggac caaatttata ggaaagcctt 1740 gcagaaggtg agagaggagg aagctgagga ggaggagagg aagcatggca aaagcaggtc 1800 cgctcagtcc ccaaatttac agacctcatc catggatgaa atcttccagc atctgaatgc 1860 ctaccgccag gaggctcaca actgcatctc cagccacatt ccattgatca tccagtattt 1920 catcttgaag atgtttgctg agaagctgca gaagggcatg ctccagctcc tgcaggacaa 1980 ggattcctgc agctggctcc tgaaggaaaa gagtgacacc agtgagaaga ggagattcct 2040 gaaggagcgg ttggcaaggc tggcccaagc tcagcgcagg ctagccaaat tccctggtta 2100 agctggccct gtcctttcct gtgtctcctg gataattaaa tattcaggga cagaagggtt 2160 ccagccttgt tgtggtttgc cctaagatat ctgtattttg atgctaattc cactgcccca 2220 gggacagctg cctagtcctg tactcaggaa tcaggtgact tcaccagaaa cttctcccca 2280 ttgaatttgt aaaatacagg tgaggggcac atagaggata gaaagaggcc tgtaattgga 2340 ccagaagtaa ggattggtgg gagagaagtt taaaggaagg ggaggatact ggaagggaaa 2400 gaaggagagg agagagatag agagaagcca tggcaggaca atatggcagg tgacattaag 2460 attccatgct gtacctttac aggttgttac aaatgttctt aagggatgga tggtactggg 2520 ctttgtatgt ttaggtgggc aattatatct taccaattgg gtcaaaaaaa aaaaaaaaaa 2580 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 2623 <210> 29 <211> 2091 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2091) <223> creg1 <400> 29 gcaggtgctc tgcagtcagc gccatggctg cccgcgctcc tgagctcgcg cgctccctgc 60 ttgctgccct tctggctccc gcgctagtgg cactactggt gtcgccggcc tggggacgcg 120 gaggccggga ccacggggac tgggacgtgg acaggcgact gcctccactg ccaccccgcg 180 atgacgggcc gcgcgtggcc cgcttcgtga ctcacgtctc ggactggggc tcgctggcca 240 ctatctccac gagagaggag gtgcgcggca ggcccttcgc ggacatcatc tcaattagtg 300 acggtcctcc gggagaaggc tcaggcgagc cctacatgta cctgagtccg ctgcaacaag 360 cagtgagcga cctgcaggga aatccagagg ctacgctgac tatgtcttta gcacagactg 420 cctactgtag gaaccatgga tttgatcccc agagtcccct ctgtgttcat ataatgatgt 480 ccgggactgt gatcaaagta aatgagacag aagagggcta cgcacgggac tcgctattca 540 tcagacaccc tgagatgaaa cactggcctc ctagccataa gtggttcttt gctaagttaa 600 aaataagcaa tatctgggtt ttggactact ttggtggacc gaaagtagtg acacctgaag 660 aatattttaa cgtcacactg cagtgaagca aatacggtga actggatcac accagcgaca 720 ggtcttccaa ggctcatgca cacagagggc tcgaccctgc ctggctgcta gcccactctg 780 ccacctcttg tttcgatttc ctttgcttgt ctttgcagag tgttgtccat tagaagacgt 840 gcttgctgga tttaaaaaaa aaaaaaaaag tcttgaagcc attttcagag aaaaatgccc 900 ttctttatga tcaaggaagc catgctcggt gctttttcct cagtggtgcc ctcagtaggg 960 tgacatatac cagctgtaga ccgcccattg gcactggagg tccagaggtg cagatgctct 1020 gtgcctgatg gccactgtgc ctgaaggtgc tgtgctcacc cagctgcctc aggagccagt 1080 gcagaggggc cgtatgaatc ctccagtcca ggacagcagt gaccacggat gcagcgtccc 1140 attcacgtca acctgtatag ctgatcagca caaggcaaag ctgggtcttc tgtaaaactc 1200 cataaacgtc ttacattcta aagtcatcgt tacccagaac aaaataaatc agaaagattt 1260 tcctgcatcc attctccatc taagtagact gtacactcac tcctcatcct tcggaatgtg 1320 cacgcctgag ctggggcgca gctttcttgg cacagagctt gccaagcatg aatgggacca 1380 taacgtcgaa acaaccagcc agccacagac gacatcttta tgtgcatgaa aaagcaacct 1440 cagaagaaaa aggatttcgc atatgttggg ctctttttcg taagacttaa ccctgtgcca 1500 gccgcaatcc aagccctcct ccggcattct gtatcttgaa gctcctggtg ctgccgcctg 1560 cgtcctctgt gggatgtacc acggtactgt ggcataaaaa caaactacaa caacaacaaa 1620 acatgtctct gcaccagagg atggctcagc ttgtaagatg actgctctag cagaggaccc 1680 aagttcagta cccgcaaggg gtcagacagg cacatatgcc cagaactcca gctccaggag 1740 atcaaatacc tctagcctcc aaggtcacct gcactggaat acacacaccc acacatagac 1800 acacagcgac acaatttcaa acagtacatc ttttattcca aagaggtact acttagttta 1860 attacctgtt tcatgctctt ggatgacata agatttcttt taacagagtg tgggggaatc 1920 aagacactga cttaaacagc caaaaaaaaa aaaaaaaaag ttaactatga accatcatgt 1980 tggagaaaga gatggtaatc ataacagaaa tccagcaaac gacgtctcag tcaaaaccca 2040 ctaaacagta aggatcttgt tattgaaatc agtaattaaa agcattatta t 2091 <210> 30 <211> 5079 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(5079) <223> LOC682058 <400> 30 cattgaaaaa tcccggaagt tactggcgtc tgtaggcgtg gggcctgctg tctgtggtgt 60 agagcacagg ttcatggctc gcacgaagtg tagcggcgtc cgtcgcggtc cgggcggtgg 120 gaagggaccc ctgaaacggc tacggctggc cgtggaaggc ttcgtgcggg ctacctccga 180 gagcgaagcc tgcgagaatc gcagcgctgt ggcgcgctcc cggcctggcg accgaaagag 240 ccgcaaggag cttcgtaaga agaagcgaca gctgaggaaa gtgcggcgcc tgcagaggac 300 agtaggctcc ggatcagggg accaagaagg gaatgtcggc cttaacggtg gcccggaaac 360 tcggccgcgc attgagatga ggccgacccc cgccaaggct acagcaaccc ctgtcaaggc 420 cagtgctccc tccgctaaca ccaaggcctc ggcgacccag cctaaggcca atagttccta 480 ctccaagggt accatgactt caactcaggc aaaggctaaa ggtgctcccg gaaagcctgg 540 tcctgccacc gccactgccc ggaagcgggc acttctagcg gccaatgagg aggaggaccg 600 agagatcaga aagctggaac gatgcctcgg cctccacaag cgtaagaagg gtgatggtag 660 ctccgtaccg ctcagtttcg cgcgcgacgg tctagactac atcctggggg ccctggaata 720 tgggagaagc ggtggcctgt acgaaagcag cgatgaagag gaggaaggaa aggtggagac 780 tggacagaca ttcttggaga gtgaccctga gagcaattct gaagaaagtg aggaggaccc 840 agactcgcaa gtgccgcagg aggatcagga agatgtaaac tcccaaaagg aaggagaaac 900 agaaagtggg acaagaggaa ataaagggaa taagaaagtg cgttttgcag aagttgtaga 960 aaagagcgaa agttctttgg aagatgactt agaacatcag gagagtcact gtgttgaaag 1020 tggtgaaaag tacatccctc ctcagttgag aagtgaggag acagtagatg tccaaaagaa 1080 agaagagcta gacaggctca agaaacatgt taaaggccta attaacaggt tgagtgaacc 1140 aaacatggct tctataagtg ggcagctaga ggagctgtac atggcccaca gcaggaagta 1200 catgaacgat actctgactg ctgtcctcat ggatgcctgt gtcactacct caaccatgcc 1260 cagcagactg atgatggagc atgtcttctt agtcagtatc ctccaccaca cggtcggaac 1320 agaggttggt gcttgcttcc ttgaagctgt ggtgaagaag tttgatgatg tctatagaga 1380 tggaggtgag gggaaagaac tggacaacct ctttaccatg attgctcatt tgtacaactt 1440 ccacgtggta cagtctctcc tcatctttga cattttaaag aagcttgttg gaacttttac 1500 ggaaagagac attgagctga tcctgttgat gctgaaaaat gtgggctttg cattgagaaa 1560 agatgatgcc ttgtcactta aggaactgat cacagaagcc caggcccagg ccattggtgc 1620 aggcaacaag tttcaggacc agaacagggt acggtttatg ttggaaacaa tgctggctct 1680 gaagaacaat gacatgcgta aaatccctgg ctataatcct gagcctgtgg agaagctgaa 1740 gaagttgcag agagctctgg ttcgaaatgc tagctcaggt tctgagactc agcttcgcat 1800 ctcctgggat ggcatcttga atgcagagca gactggtcgc tggtggattg tggggtctgc 1860 atggagtggg accccaatga ttgaaaacca tcacacacac ctgcagaagc cacttgcagg 1920 cacggctagc tctaagatgc tggagcttgc caggaagcag aggatgaaca ctgatgtcag 1980 gaggaatata ttctgtacta tgatgacaag tgaggacttc ttggatgcct ttgagaagct 2040 gctgaagctt gggctgaagg accagcagga gagagaaata gttcatatcc tcatggactg 2100 ctgcctgcaa gagaaaacct acaacccttt ctatgctttc ctggccagca agttctgtgc 2160 ctatgaaagg agattccaga tgactttcca gttcagcata tgggacaaat ttcgggactt 2220 agaaaatttg tcaggcacta agttctcaaa cctagtttat ctgctgacac acttgttgaa 2280 gacaaagtcg cttccacttt ctgttctaaa ggtagttgaa tttagtgaat tggataaacc 2340 cagagttcac ttcctgcgga gagtgttgac tgagctgttg atggaaacag aagacgatga 2400 cctggttgtg attttttcaa gagtgtctag caacccaaaa ctgggaatgt tgcgagaagg 2460 cctgaagctc ttcattagcc acttcttact gaagcctgca cagcctcagc agagtgctga 2520 gaaggccagt ctgctgcgag agagggccgg tcttgcctct aagtctttac agggcaaagc 2580 catcctgagg atgtaaacaa agaacaggga gcatttgacc aagagatgtg atttctgagt 2640 tcaagaccat cctgcctttg taagagcggg aggagttatg ccatgttctg tcatggttta 2700 aatactgtat tttcagggtt gtactgtgta cttcaagtgt atatgtgtat acagcaggtc 2760 agaggaaagg gggaaagaag atgggaatta aaccctgagg ggagggttgg gaatcataaa 2820 ttgatggctt tttaatcatc taaaatgtta aaaaaaaaaa gtttaaaagc tggggctggg 2880 gatttagctc agtggtagag cgcttacctt ggaagcgcaa ggccctgggt tcggtcccca 2940 gctccgaaaa aaagaacaaa aaaaaaaaaa aaaaaaagtt taaaagctgg gcacatggta 3000 tcacatgact ttaattccac cacttgggag gcagaggcag gcagatctct taagttccgg 3060 gccagcctgg tctacatagt tctaggacag ccagagcaaa ttgtgcgacc ctatctcaaa 3120 aagaaaaagt tcaaatcccc taagagactg gtgcttaggc tctgatatct ccactcagca 3180 gtcccactga cttcaaggag gagagagaga agaacagaga taaaatgatt gtgtcaggta 3240 agggtagcat gggctcacag tctgaagaag gaatggcctt ggatacatga cttccatcct 3300 taaagtttga atcgcctctc aagtgctgca gacttggcta accctgacct tcagttgtaa 3360 ctaaatagaa gtagaaaagt cctaagtcag agcttttcgc gcagcagtat tctgtgcaga 3420 gtgccctttc gaggcatgca ggcaggcaca gacaagggat gctgctccta tgtgactcac 3480 cccttcggtt agacttttaa cagcacatcc ctgtagcagt gtgtttgaaa tgactgtgta 3540 cagtcaggaa gtctccatgt ggatccctga gaactgagcc atgaagtgag ctagcagtgt 3600 ctgctgctgt tcttgttgct atgacaaacc tgacaagagt gcataaggaa gggtggcctg 3660 ggctcataca gtgtatacac atcatagtgg ggtatcaggc agcaagagct caaggcatct 3720 tgtcacattg catctgcagt caggaagcag agagagacac aggtacttgg ctcacttctc 3780 cttttcatta agtccaagcc ccagccaagg catagtgcca tccatgttca ggacatccac 3840 ccaaattagc ccaatcaaga aactctcaca accactcgca gaggtttgct tcctaggtga 3900 tgtggagcct atcaagtggg cagcgtatct agatctgggg ttaggagtga accatagtgg 3960 aacacttgct cggactctag gcacccctca gctttacaca acaaagtgtg gtttacttac 4020 cttttctgaa ttttatttat atgtgagtgt atggacatgt gtacaagtga aggccagaag 4080 agggtgtcct ggaggtcgag ttccaggtgc ttgtgagcag cctaattggg gttgtgggac 4140 ccaaactgag ttccttttag gagaacagca agcactctca agccagatct ctagccccag 4200 gtatgtcttc ctccccaccc gaccccatgg aattaaaggc atatatcacc acgtcaggcc 4260 caactctgtg tgtgtgtcag tgtgcttata gtaaaagaac taatgtataa gcttggtgca 4320 gtggcacaca cctttaatcc cagactttgg atgcagaggc aaacagatca ctgacagttc 4380 tcatccagcc tggtcctcag taagtaccag gactaaagaa cctgtcacaa aagcaaacat 4440 gtatagaatc actttttaaa gggggaattt tatctgtaaa ataaaagtgt aaattttggg 4500 gttggggatt cagctcagtg tagagcgctt acctagtaag cgcaaggccc tgggttcggt 4560 tctcagctcc aaaaaaaaaa aaaaaaaaaa gaaagaaaag tataaatttt atgtaaaaat 4620 aaattacttt taagctattt tctgtagtgt gtcaccacca ctgacactga ggctgacttg 4680 tctcatggct tgttggcttg gatccatccc aaaagctgct gacacagtgt aagaatgtcc 4740 atacttggtt caccaccaga ctcttccctt tatcatgtga cttttctgaa caaaacaaaa 4800 catattggat accaagaagc catgtccaaa tggaggagac agctgcgtgt agagggttat 4860 tagccttctg agttgactct agatggacag tgtctgaggt gatatctcta tttctaatgt 4920 gttaatctta ctctacatta agaagcagaa ccccctttca ccacttgata tcactgtgta 4980 ctcttagatc cctattttac cttaatgtag gccatgcttg attcaagtgt gcttttcaag 5040 acacaggaaa attttcatgg aaaggatttc atttctcaa 5079 <210> 31 <211> 2132 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2132) <223> Camkk2 <400> 31 ccggaccgag tcgagccgag ccaagccgag ccgggggcgc agagcgcggg aggcggcggc 60 gcggagccca ggcagctcta ctgctgatgg aagtgctccg gcctggccga tgaagttggt 120 acacacacca tgtcatcatg tgtctctagc cagcccacca gcgaccgggc ggccccccag 180 gatgagctgg gaagcggggg tgtcagccgg gaaagccaga agccctgcga ggcactgcgg 240 ggactctcat ccttaagcat ccacttgggc atggaatcct tcatcgtggt caccgagtgt 300 gaaccaggcc ggggcgtgga cctcagcctg gccagagacc aacctctgga ggccgatggc 360 caggaactcc ctctggatgc ctcggaacct gagtcacggt ccctgctttc tggtggcaag 420 atgtccctcc aggagcggtc ccagggcggg ccggcgtcca gcagcagcct ggacatgaat 480 ggacgctgca tctgcccatc cctgtcctac tcaccagcca gctccccaca gtcctctccc 540 cggatgcccc ggcggcccac agtggagtcg caccacgtct ccatcacggg tttgcaggac 600 tgtgtgcagc tgaatcagta cacgctgaag gatgaaattg gaaagggctc ctatggcgtt 660 gtcaagctgg cctacaatga aaatgacaat acttattatg caatgaaagt gctgtccaaa 720 aagaagctga tccgacaggc cggctttcca cgtcgccccc cacctcgagg tactcgccca 780 gctccagggg gctgcatcca gcccaggggc cccatcgagc aggtgtatca ggaaattgcc 840 atcctcaaga agctggatca ccccaacgtg gtgaagctgg tggaggtcct ggatgaccct 900 aacgaggacc atctgtacat ggtgtttgaa ctggtcaacc aagggcctgt gatggaagtt 960 cccaccctca agccactgtc tgaagaccag gcccggttct acttccaaga tctgatcaaa 1020 ggcattgagt acttacacta ccagaagatc attcaccggg acatcaaacc ctccaacctc 1080 ctagtggggg aggacgggca catcaagata gccgacttcg gcgtgagcaa tgagttcaag 1140 ggcagcgacg ccttgctgtc taacaccgtg ggcacgcctg ccttcatggc gcccgagtcg 1200 ctctcagaga cccggaagat cttctccgga aaggccttgg atgtttgggc catgggtgtg 1260 acactatact gctttgtttt tggccagtgc cctttcatgg atgaacgaat catgtgtttg 1320 cacagtaaga tcaagagtca ggccctggag tttccagacc agcctgacat agccgaagac 1380 ttgaaagatc tgatcacccg gatgttggac aagaacccag agtccaggat tgtggtgcct 1440 gaaatcaagc tgcacccttg ggtcacgagg cacggggccg agccactgcc gtcggaggac 1500 gagaactgca cactggtcga ggtgaccgaa gaggaggtcg agaattcagt caaacacatt 1560 cccagcctgg caactgtgat cctagtgaag accatgattc ggaaacggtc ttttgggaac 1620 ccatttgaag gtagccggcg ggaggagcgt tccttgtcag cacccggaaa cctgctcacc 1680 aaaaaaccaa ccagggagtg ggagcccttg tctgagccca aggaagcaag gcagcgaaga 1740 cagcctccgg ggcccagagc cagcccctgt gggggaggag gaagtgctct tgtgaaaggt 1800 ggtccctgcg tggaaagttg cggggctccg gcccctggct ccccgccacg cacgcctcca 1860 cagcagcccg aggaggccat ggagccggag tagctgcgcg gaccacctga cctcgcatgc 1920 ctggctgtgt ggccctgcac ggggctgctg caccctgcgt ttccatagca gcatgtccta 1980 cggaaaccaa gcacgtgtgt agagccttga ctgtcatctc tggttatcag ttttttgttt 2040 ttgtttttgt ttctttttgt tgttgctgtt gtttttcttg tggtttttct tttctttttt 2100 tttctctccc tttgttgtct aaggggacaa ag 2132 <210> 32 <211> 4480 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(4480) <223> Mobkl1b <400> 32 gcacggagga ctccgcagtc tgtgctggtt cggggcggct ggaacccagt acgaaaccca 60 agccgtgaag cttcggcagc cctgttgagc cgcggaccgc cctctgcttc ccggtgcccg 120 cggcggcgcc gagtctgacg gggcgggggc cacggcccct cgggctagca aggatgagct 180 tcctctttag cagccgctct tcgaaaacat tcaaaccaaa gaagaatatt cctgaagggt 240 cccatcagta tgaactctta aaacatgcag aggcaactct cgggagtggc aatctgaggc 300 aagctgttat gttgccggag ggagaagacc tcaatgagtg gatcgctgtt aatactgtgg 360 atttcttcaa tcagatcaac atgctgtatg gaaccattac agagttctgc actgaggcaa 420 gctgcccagt catgtcagca ggtcccaggt atgaatacca ctgggcagat ggcactaata 480 ttaaaaagcc aattaagtgt tcagcaccaa aatatattga ctatttgatg acttgggttc 540 aggatcagct tgatgatgaa actctttttc cttctaagat tggtgtccca tttcccaaaa 600 actttatgtc tgtggcaaag actattctga agcgtctctt cagggtttat gcccatattt 660 accaccagca ctttgactcc gtgatgcagc tgcaagagga ggcccacctc aacacctcct 720 ttaagcactt tattttcttt gttcaggagt ttaatctgat tgataggcgt gagttggcac 780 cacttcagga actaattgag aagcttggat ctaaagacag ataaatgctg cttcttctag 840 aacacagtta ccctccccct ctatctactg ctagcactct ctcattgctg tctggtatgg 900 actaagtgat actgactaca agaaaccagg atcaaaagat ccattgcgtc tgaaaaaaaa 960 attgtcccaa aggtaggttg gccagatagc ttcagaacaa tcccatgaca cagctaaatc 1020 agaggtgctg tgtggccacc ctgttactgt taatgtcctt ctttgttttc acctcatgac 1080 taacctgtag tttgttgctg agttttgttc aagaaaatga gtttttccgt gggacaacat 1140 aatggacatt aagaattttc agcagcaact tattagtgac cttctagaac aaatgtctta 1200 acacagatga gtttgctttg ttttacaaat cagtggtggt ctgtttcact ttggatagcg 1260 ttttggttca catttgtata ctgatgttta taggcaagag tgtatgtttt ctagccaggc 1320 atgatggtcc atgcctgtta ggggcaaagg tgggaggatc acacatttga ggctggcttg 1380 ggctacattg tgaaactatt gctaaaaaaa gtttgttttg caaaatccac aaggcttaaa 1440 tcacaggcat atgtggactg agattaacca aagttatttt aagtgacttt actgtgtaaa 1500 cttgtttggg attgtcttca tgtctgacta gatgaggaga gtgcacgaca gatttaatct 1560 ttgtggcttc tgacagcgtc gtgcaggttc tcatttgagg ctcttgactc agattaactt 1620 catatgtagg ctggggcaga gatcaagaaa acttccaaaa tctgtgacat acttgggcct 1680 caaagccact gttttcattg atatttcttt gcagttcttg aggcacagta gaaaaagtag 1740 tcagagtact tgattatttc ctggatgatt ccatgttttt attgcaactt gaaacttttc 1800 tgtgcacgta aaatgcacag acttcatggc gataggacaa aggtcaaaac cacagaatag 1860 cttgcagggg tgtgtgacag caggtctccc tgggcctgtt aaagctggag acccagcaag 1920 gggagtgaat tgggcagctt ggcttccttc tgttactgag cacaggctgc agtgagctct 1980 aatgcttcca tcctccttgc ctttgtagca aaacttgaat ttttcctcat cctgtcagga 2040 taaaagaatc ctcttttggg gaagtgcctg cttttcctgt gatcctcaga cctagtctgt 2100 tctggctgcc ttttcaaatg tacatgacat cccagggatt ctggaccctt gcccaacagg 2160 cagtgctgga gtttatcatt gttgtgtgtc agagctggga cttacatagt gctcactggc 2220 ctcctacatg gcttaataaa agttagagtt gatgaggttt ttgttattta ttttgattcc 2280 actagactat actggaaagt attgcttaga aactccagtt ttaataactc attttcagta 2340 tgttcttaag tatgctcaga attttaaagg aactgttttg tctttatttt ggctgaaatc 2400 acctatcacc gttagaggaa ttcaagttgg aatgacggtt taggtaaaaa gggcagcttg 2460 gaaacacctc acagcccagg tgtatgcaaa tgtccagaca tcagctgttc tgtaagtgta 2520 tgacagtcac ctgcagaccg gaaacaggct tctagatgat caagaatgtt tcacctctca 2580 accctagact ccatttactt tgatttgctt tagtctctct cttttttttt tttttttttt 2640 tccagagctg aggactgaat ccagggcctt gcgcttgcta ggcaagcgct ctaccactga 2700 gttaaatccc caacccctgc tttagtctct taaggaatga aattctcttt ctcaaccagg 2760 gcccaatcat ttttatgagt tccgataccc tcaaaaccaa ggtttctctg catgtatttt 2820 ggggatagaa atgccctctc catgtctgag ctcccaatgg tagatgttaa gatacggagg 2880 aggcagcccc tagtgggata taaagcaaag ccttgctggt gaaaaagagt atctctgttt 2940 ttggttgtgt ccccctcccc ttttttcctt ttatcattga aaacagtgct agactcccac 3000 accaacctgc cttaatcagc agtgtgcaca ctgcgctgtt gctcagtgag gcaaagacat 3060 gggaggagga gtttgtcttt ctgctttggc tagagggctc atttataaca tctgaagaaa 3120 tcagtctgtc ctgggtttat ctgcatattt catggctctc ctgctcccct cagcaggagt 3180 cagctgttct gtctgattct gctctctgga ctttgttgca gtgacttccg attgactggt 3240 gaattctgcc ttagccctgt ggtgctttaa ctttcaggac ttgaaaaact tggatattgg 3300 ggactgaaga gatggcacat tgtttaaagc attggctgct cttccaaagg accctggttc 3360 aatttccagc acccatatgg tggctcacaa gtgtttgtaa ctcaagttcc agtggatcca 3420 actccctcac acaaacatgc atgcaggaca aacaccaata cattaaatta aaaaaaaacc 3480 ttggccaatg atagatttat aaaaaatact tacacttctc ttgtacaatt tttgtgtcaa 3540 ctgctactat attgttactc tgctgattga gtaaagtgtc ttaccagcag ccagttagcc 3600 aggggtcctt ttatctgcag ctccttggcc tgcagagcta gtttagttca cacaactgct 3660 cactggagaa ttgcaggtct ctgttctcca tggcttgtag caaaggcaca ggcacagtcc 3720 tggcggtgag gtttcctgtt tgtactcttg gcttctctct gagccccaag atcatactaa 3780 atatagcgtc tcatagcttc tcagacatgt cattacctca ggcacataaa caaatcaaga 3840 ctgaagagtg aggcccctac aagtgtgtgt ccactcccca gtcagaatgg agtcctgaaa 3900 cactgccagc ctgggcatgc gctgctgagc acctttagca gtcatgttct ttccgcctga 3960 ggtcagtgag agttctgaca aagaaggaag ccacagtagt ctttggtctt cctgacttta 4020 cattcaattt tgatgcaggg ctttgatggg ctttggagca catgtggcag cagtaatttt 4080 actgaagcaa ctgcattgaa attcactcgg gttttctcat cagaacgtat cacatagttt 4140 tctgtaaagc cattctggat ggccagtgtg ctgtggacta gttataaaac agcattctgt 4200 gttggtctgc ctcaaaaata gtttgcataa agtagtcttc gttaccatct aaaataactt 4260 aaaatattcc tcacgtaaaa aatttatgtt gtatttttaa aacttttagg gctttatcta 4320 tttttctaag tcgttaactg tactttttaa aaaagtattt tatacctact tttgtaactt 4380 catcagaata aactatattg aaaccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4440 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4480 <210> 33 <211> 2179 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2179) <223> Agtrap <400> 33 gtccccgtgg ccgtcgctca ggtgccctcc gccgggtcgg gatggagctg cctgccgtga 60 acttgaaggt tattctcctg gttcactggc tgttgacaac ctggggctgc ttggcgttct 120 caggctccta tgcttggggc aacttcacta tcctggccct gggtgtgtgg gctgtggccc 180 agcgggactc tgttgatgcc attggcatgt ttcttggtgg cttggttgcc accatcttcc 240 tggacattat ctacattagc atcttctact caagcgttgc cgttggggac actggccgct 300 tcagtgccgg catggccatc ttcagcttgc tgctgaagcc cttctcctgc tgcctcgtct 360 accacatgca ccgggagcga gggggtgagc tcccgctccg ctcggatttc ttcggacctt 420 ctcaggaaca tagtgcctac cagacaattg actcgtcaga ctcacctgca gacccccttg 480 caagcctgga gaacaagggc caagctgccc cccgggggta ctgaagctgt ccctggccgt 540 cctggggccc agcaggatgc ttgtcacctt ctttactgga cctacaatgg ggtatcctcc 600 attccctgcc acagaggtgg cctgagtcat gtgccctcgg aggtcccagc tgagaagagc 660 ccagtcctaa ttctccatgc tgcccctcca ttcaagacac ctgttaaccc ctgggctaga 720 actgtggttg gtttcttccc ctcctcccca tcactataac acacaaccgc cgagctgtgc 780 agagtgttca gggccatcca ggccttatgg gccaatgatc actgcctctc aggctacccc 840 aaggtgaccc agcccttctg gaagctctgt gagcttgtgg tcctgctcag cctgttctgc 900 acaggagcca agtccctgtg cctctcagtg cctcatgaca gtgcctgaga accccaggcc 960 cagatgcagt aggtctgtct gcagaggagc cctgacatta aaatgcaggg cctctgggcc 1020 tgcactaggt tccagccatg tttgtgctcc gagctgggac ccaccctgcc gtctgggtgt 1080 gacttcgccc tagactcagt tgcaggtgga acatagtttc agccacccat tatatcagcc 1140 aaatggggtg gcagaggaag tgctggtcgg tgtggcatgt agacagacat ctatcctctg 1200 attctaagtg actaatttca ctgcctctga tcctgaacca tgaggcaggg catgggtggc 1260 ttcctctagc ctctgcgttc tgaccacagt cgactgcctc ctgaggtgcc agcgctccca 1320 ctcttactca ccggcagacg tctggggaca gatacttgaa gacttatggg gagccgcagg 1380 ctgaggtgag agtcctgaaa gcactctctg cacacgagac aggccgggag gctgagtgac 1440 agcatcattg gtggggtcac tgcgtccatc tgctgcgtca aacacaatcc catgcaatca 1500 gcacctaacc cagacctggt tggcatccac actgagccca gtgtgagcag agtgaggagc 1560 ggtagctgtg atttgtttag gctgagtgca gcacagtgta aacaagagct ggggcccaga 1620 gactcagagg cttagaggct cagccgcagg taaaggagtc ttctactgag cgtcacgatg 1680 tgtgtttggt ccttggaacc gacttgcgaa agttatcctc tgacctccac actctttgtc 1740 atggtttgag gttttacaca cacatacaaa cacaccacaa acagataaat gtaaaaacaa 1800 acccagaata ttaaaaacgt gcctggtggg tggttaatgc cagcacttgg gaggcagagg 1860 caggtgaatc tccgagttaa ggccagcctg gcctacagag cgagttccag gacagctggg 1920 gctgtttcat agctctggga cacgtgtcaa gttcaagact gcagaggcct gaggagaagg 1980 gagcacgtgg cctgaggcaa agaagacaag aagcccaaga tgttttctcg tgtttctgga 2040 agggttcttg tcggaaggaa ggcctggggg ctggggattt agctcagtgg tagagcgctt 2100 acctaggaag cgcaaggccg tgggttcggt ccccagctcc gaaaaaaaag aaccaaaaaa 2160 aaaaaaaaaa aaaaaaaaa 2179 <210> 34 <211> 2579 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2579) <223> Adpgk <400> 34 aaaggatctc gtagtctcca gtgcggcagt gtgtccacat ggcgctgtgg cgcggctctg 60 cgtgcgccgg cttcctggcg ctggccgtgg gctgcgtgtt tctgctggag ccggagctgc 120 cgggcacagc gctacgctcg ctctggagct cgctgaggct ggggcccgcg ccagtgcccc 180 cgggatctct gtccccagag agccggctgg cggccgcttg ggatgccctc atcgtgcagc 240 ccgcccggcg ctggcgccgc gtggctgtgg gagtcaatgc ctgtgtggat gtggtcatct 300 ctggcgtgaa gctcctgcag gcactcggcc taagtcctgg gagtggaaga gaccatgctg 360 ttctacactc aagaagtgat ctggaagaag cctttgtcca cttcatgggg aagggagctg 420 ctgctgaacg cttcttcagt gatagagaga cctttcatga cattgcccag gctgcatctg 480 agttcccagg agcccagcac tatgtaggag gaaatgccgc tttaattgga cagaagtttg 540 ctgccaaccc agacttaaag gttcttcttt gtggtccaat tggcccaaag ctacatgaac 600 ttcttgatga caatgtgttt gttccgccag agtcactgca ggaagaggat gagttccacc 660 ttattttaga gtacctggca ggggaggagt ggggcccgtt taaagctccc caggccaacc 720 ggttcatctt ctctcacgac ctctccaacg gggccatgaa tatgctggag gtgtttgtgt 780 ctagcctgga ggagttccag cctgacctgg tggtcctttc tggattgcac atgatggagg 840 gacaaagcaa ggagctccag aggaagaggc tcttggaggt tgtgacctcc atctctgaca 900 tccccactgg tattccagtt cacctagagc tggccagtat gaccaacagg gagctcatga 960 gcagtattgt gcatcagcag gtctttcccg cagtggcttc tcttgggctg aatgaacagg 1020 agctgctgtt tctcagccag tcagcatctg gaccccatgc ttctctctcc tcttgggatg 1080 gcgttcctga tgtgggcatg gtcagtgata tcctcttctg gatcttgaaa gaacatggaa 1140 ggagcaaaag cagatcgtca gatctcacca ggatccattt ccacacgctg gtctaccaca 1200 ttctggcaac tgtggacgga cactgggcca accagctcgc agctgtagct gcaggagctc 1260 gtgtagctgg gacacaagcc tgtgccacgg aaaccataga caccaaccga gtatctctga 1320 gagcacctca ggagtttatg acatcccgtt tggagcccgg ctccaggatt gtattaaacc 1380 caaataagcc agtggtggag tggcacaggg agggggtcac tttccacttc acacccgtgt 1440 tggtgtgtaa agaccctgtt cgaactgtag gccttggtga tgccatttct gctgaaggcc 1500 tcttctattc agaagcatac cctgattagg aatgctgtag acagttatat gaggaatgaa 1560 agccacccat cttaagaatt ccaggacgaa catagcttgg gaaataggct tgtgggtgtc 1620 agaacagttc ctagatctaa ttggaaggca gccaaagaaa tcacagcaga ttaaactgca 1680 cagatacatt ccagcctgtt ggcagcataa aatcacttca ggtataatcg aaacgtagct 1740 atctactaac gagactggat ttttgttttt tgtgtgtgct acaaaggtta agaacacctc 1800 cctgggggat tggggtttag ctcagtggta gagcgattgc ctagcaaggg taaggccctg 1860 ggttcggtcc tcagctaaaa aaaaaaaaaa gaacacctct ctgaatcccc agttgatgta 1920 ccatgactct ggagagtctc ctccggccgc agaaagcact tccctccttg ccctctagag 1980 aaggcagtcc tcccccacaa gactgaccac tcgtgaaacc tgctgaaggc agtcatgaca 2040 ccttatgctc ctggcagaat cagcttgtcc attcagtgtt agagtgacaa tatttgacat 2100 gtgtaccttc tcagcctcct gttctcagac ataggtcaga gccgcaagag aggacaaaac 2160 agtcctgtgc tttatgggct aggattggag attcttggga gagccttgag ccacctaatc 2220 attctgcacc tgcttgggag catcatgcct tcctgcctca gcttcagaga ttggggctga 2280 ctgagaaaag gccctatggc ttgttctcag cctcagtgcc gagcctggaa atgctttctg 2340 cagcaggaga ctggttctcg tttcttctga gccttgaaga gatgtgtctt acaactggaa 2400 agtgcttcag tatagaacac atcatgtgtt ttgtgttttt gttttgacac atccattagt 2460 ttgacctctt aagagcccca ggatcatgaa taaatgtgtc gtgttgtata tttatttttt 2520 taataaatca agatttctgt gtgcttttaa aaatattaaa acaatttaca tttccagga 2579 <210> 35 <211> 2582 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2582) <223> Nr4a2 <400> 35 tggatcccca aattgctttt taaaaaatat cttggaaact ttgtcctttg ctgaattacg 60 acactgtcca cctttaattt cctcgaaaac tccaatcact cggctgaagc catgccttgt 120 gttcaggcgc agtatgggtc ctcgcctcaa ggagccagcc ccgcttctca gagctacagt 180 taccactctt cgggagaata cagctccgat ttcttaactc cagagtttgt caagtttagc 240 atggacctca ccaacactga aattactgcc accacttctc tccccagctt cagtaccttt 300 atggacaact acagcacagg ctacgacgtc aagccacctt gcttgtacca aatgcccctg 360 tccggacagc agtcctccat taaggtagaa gacattcaga tgcacaacta ccagcaacac 420 agccacctgc cccctcagtc cgaggagatg atgccacaca gcgggtcggt ttactacaag 480 ccctcttcgc ccccgacacc cagcaccccg ggcttccagg tgcagcatag cccgatgtgg 540 gacgatccgg gctcccttca caacttccac cagaactacg tggccactac gcatatgatc 600 gagcagagga agacacctgt ctcccgcctt tcactcttct cctttaagca gtcgcccccg 660 ggcactcctg tgtctagctg ccagatgcgc tttgacgggc ctctgcacgt ccccatgaac 720 ccggagcccg cgggcagcca ccacgtagtg gatgggcaga ccttcgccgt gcccaatccc 780 attcgcaagc cggcatccat gggcttcccg ggcctgcaga tcggccacgc gtcgcagttg 840 cttgacacgc aggtgccctc gccgccgtcc cggggctctc cctccaatga gggtctgtgc 900 gctgtttgcg gtgacaacgc ggcctgtcag cattacggtg ttcgcacttg tgagggctgc 960 aaaggtttct ttaagcgcac ggtgcaaaaa aacgcgaaat atgtgtgttt agcaaataaa 1020 aattgcccag tggataagcg ccgccgaaat cgttgtcagt actgtcggtt tcagaagtgc 1080 ctggctgttg ggatggttaa agaagtggtt cgcacggaca gtttaaaagg ccggagaggt 1140 cgtctaccct caaaaccgaa gagcccacag gatccctctc ccccctcacc tccggtgagt 1200 ctgatcagtg ccctcgtcag agcccacgtc gactccaatc cggcaatgac cagcctggac 1260 tattccaggt tccaggcaaa ccctgactat cagatgagtg gagatgatac tcaacatatc 1320 cagcagttct acgatctcct gactggctct atggagatca tcagagggtg ggcagagaag 1380 attcctggct ttgctgacct gcccaaagcc gatcaggacc tgctttttga atcagctttc 1440 ttagaattat ttgttctacg cttagcatac aggtccaacc cagtggaggg taaactcatc 1500 ttttgcaatg gggtggtctt gcacaggttg caatgcgtgc gtggctttgg ggaatggatt 1560 gattccattg ttgaattctc ctccaacttg cagaatatga acatcgacat ttctgccttc 1620 tcctgcattg ctgccctggc tatggtcaca gagagacacg ggctcaagga acccaagaga 1680 gtggaagagc tacaaaacaa aattgtaaat tgtcttaaag accatgtgac tttcaataat 1740 gggggattga accgacccaa ctacctgtcc aaactgttgg ggaagctccc agaacttcgc 1800 accctttgca cacaggggct ccagcgcatt ttctacctga aattggaaga cttggtacca 1860 ccaccagcaa taattgacaa acttttcctg gacaccttac ctttctaaga ctttctccca 1920 tgcacgtcaa agaactggaa agaaaaaaaa aatccagagg gggctggtca agatgggtag 1980 agagctggct gaagtgtccg gttcatgtct cccttctgta gacccctagc cctcacccct 2040 aaagtaaaca aacaaacaag caaacaaaca aacacaaatt aaaaactgtt gctatttcct 2100 aacctgcagg cagaacgtga aagggcattt tggctccggg gcatcctgga tttagaaaac 2160 ggacaacata cacagtacag tggtataaac ttttttatta tcagttcaaa atcagtttat 2220 tgttcagaag gaagattgca aatgtatgat gggaaatgtt tggccatgct tgcttgttgc 2280 agttaagaca aatgtaaggc aaatgtaaca cacacacaca cacacacaca cacacacaca 2340 cacacacacc tcttaatggg accctcatat tttgcccttt aacaagactt caaagttttc 2400 tgctgtaaag aaagctgtaa tatatagtaa aactaaatgt tgcgtgggtg gcatgaattg 2460 aaggcagagg cttgtaaatt ttatccaatg cagtttggct ttttaaatta ttttgtgcct 2520 atttatgaat aaatattaca aattctaaaa agtaagtgtg tttgcaaaaa aaaaaaaaaa 2580 aa 2582 <210> 36 <211> 5091 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(5091) <223> C3 <400> 36 ctacccctta cccctcactc cttccacctt tgtcctttac catgggaccc acgtcagggt 60 cccagctact agtgctactg ctgctgttgg ccagctccct gctagctctg gggagcccca 120 tgtactccat cattactccc aatgtcctgc ggctggagag tgaagagact ttcatactag 180 aggcccatga tgctcagggt gatgtcccag tcactgtcac tgtgcaagac ttcctaaaga 240 agcaagtgct gaccagtgag aagacagtgt tgacaggagc cactggacat ctgaacaggg 300 tctccatcaa gattccagcc agtaaggaat tcaatgcaga taaggggcac aagtacgtga 360 cagtggtggc aaacttcggg gcaacagtgg tggagaaagc ggtgctagta agctttcaga 420 gtggttacct cttcatccag acagacaaga ccatctacac cccaggctcc actgttttct 480 atcggatctt cactgtggac aacaacctat tgcctgtggg caagacagtc gtcatcgtca 540 ttgagacccc ggacggcgtt cccatcaaga gagacattct atcttcccac aaccaatatg 600 gcatcttgcc tttgtcttgg aacattccag aactggtcaa catggggcag tggaagatcc 660 gagccttcta tgaacatgca ccaaagcaga ccttctctgc agagtttgag gtgaaggaat 720 acgtgctgcc cagtttcgaa gtcctggtgg agcctacaga gaaattttat tacatcgatg 780 acccaaaggg cctggaagtt tccatcacag ccagattcct gtatgggaag aacgtggacg 840 ggacagcttt cgtgatcttt ggggtccagg atgaggataa gaagatttct ctggcccagt 900 ccctcacccg cgtgctgatc gaggatggtt caggggaggc agtgctcagc cgaaaagtgc 960 tgatggacgg ggtacggccc tccagcccag aagccctagt ggggaagtcc ctgtacgtct 1020 ctgtcactgt tatcctgcac tcaggtagcg acatggtaga ggcagagcgc agtgggatcc 1080 caattgtcac ttccccgtac cagatccact tcaccaagac acccaaattc ttcaagccag 1140 ccatgccttt cgacctcatg gtgtttgtga ccaaccctga tggctctcca gcccgcagag 1200 tgccagtagt cactcaggga tccgacgcgc aggctctcac ccaggatgat ggtgtggcca 1260 agctgagcgt caacacaccc aacaaccgcc aacccctgac tatcacggtc cgcaccaaga 1320 aggagggtat cccggacgcg cggcaggcca ccaggacgat gcaggcccag ccctacagca 1380 ctatgcacaa ttccaacaac tacctgcact tgtcagtgtc tcgggtggag ctcaagcctg 1440 gggacaacct caatgtcaac ttccacctgc gcacggacgc tggccaagag gccaagatcc 1500 gatactacac ctatctggtt atgaacaagg ggaagttact gaaggcaggc cgtcaggttc 1560 gggagcctgg ccaggacctg gtggtcttgt cactgcccat cactccagaa tttatacctt 1620 ccttccgcct ggtggcttac tacaccctga ttggagctaa tggccaaagg gaggtggtgg 1680 ccgactcagt gtgggtggat gtgaaggact cctgtgtagg cacgctggtg gtgaaaggtg 1740 acccaagaga taaccgacag cccgcgcctg ggcatcaaac gacactaagg atcgagggga 1800 accagggggc ccgagtgggg ctagtggctg tggacaaggg ggtgtttgtg ctgaacaaga 1860 agaacaaact cacacagagc aagatctggg atgtagtaga gaaggcagac attggctgca 1920 ccccaggcag tgggaagaac tatgcgggtg tcttcatgga tgctggcctg accttcaaga 1980 caaaccaagg cctgcagact gatcagagag aagatcctga gtgcgccaag ccagctgccc 2040 gccgccgtcg ctcagtgcag ttgatggaaa ggaggatgga caaagctggt cagtacaccg 2100 acaagggtct gcggaagtgt tgtgaggatg gcatgcgtga tatccctatg aagtacagct 2160 gccagcgccg ggctcgcctc atcacccagg gcgagagctg cctgaaggcc ttcatggact 2220 gctgcaacta tatcaccaag cttcgtgagc agcacagaag agaccatgtg ctgggcctgg 2280 ccaggagtga tgtggatgaa gacataatcc cagaagaaga tattatctct agaagccact 2340 tcccagagag ctggttgtgg accatagaag agttgaaaga accagagaaa aatggaatct 2400 ctacgaaggt catgaacatc tttctcaaag attccatcac cacctgggag attctggcag 2460 tgagcttgtc cgacaagaaa gggatctgtg tggcagaccc ctatgagatc acagtgatgc 2520 aggacttctt cattgacctg cgactgccct actctgtggt gcgcaatgaa caggtggaga 2580 tcagagctgt gctcttcaat taccgtgaac aggagaaact taaggtaagg gtggaactgt 2640 tgcataaccc agccttctgc agcatggcca ctgccaagaa gcggtactac cagaccatcg 2700 aaatccctcc caagtcctct gtggctgtgc cttatgtcat tgtccccttg aagatcggcc 2760 tccaggaggt ggaggtcaag gccgccgtct tcaaccactt catcagtgat ggtgtcaaga 2820 agatactgaa ggtcgtgcca gaaggaatga gagtcaacaa aactgtggct gtccgtacac 2880 tggatccaga acacctcggt caagggggag tgcagaggga ggatgtacct gcagcagacc 2940 tcagtgacca agtgccagac acagattctg agaccagaat tctcctgcaa gggaccccgg 3000 tggctcagat ggccgaggac gctgtggacg gggagcggct gaaacacctg atcgtgaccc 3060 cctctggctg tggggagcag aacatgattg gcatgacacc cacggtcatt gcagtacact 3120 atctggatca gaccgaacag tgggagaaat tcggcctaga gaagaggcaa gaagctctgg 3180 agctcatcaa gaaagggtac acccagcagc tggctttcaa acagcccagc tctgcctatg 3240 ctgccttcaa caaccggcct cccagcacct ggctgacagc ctatgtggtc aaggtcttct 3300 ctctggctgc caacctcatc gccatcgact ctcaggtcct gtgtggggct gtcaaatggc 3360 tgattctgga gaaacagaag ccagatggtg tctttcagga ggacggacca gtgattcacc 3420 aagaaatgat tggtggcttc cggaacacca aggaggcaga tgtgtcgctt acagcctttg 3480 tcctcatcgc actgcaggaa gccagagata tctgtgaggg gcaggtcaac agccttcccg 3540 ggagcatcaa caaggcaggg gagtatcttg aagccagtta cctgaacctg cagagaccat 3600 acacagtagc cattgctggg tatgccctgg ccctgatgaa caaactggag gaaccttacc 3660 tcaccaagtt tctgaacaca gccaaagatc ggaaccgctg ggaggagcct ggccagcagc 3720 tctacaatgt ggaggccacc tcctacgccc tcctggccct gctgctgctg aaagactttg 3780 actctgtgcc tcctgtggtg cgctggctca acgagcaaag atactacgga ggtggctatg 3840 gctccacgca ggctaccttc atggtattcc aagccttggc tcaataccaa acagatgtcc 3900 ctgaccacaa ggacttgaac atggatgtgt ccctccacct ccccagccgc agctccccaa 3960 ctgtgtttcg cctgctatgg gaaagtggca gtctcctgag atcagaagag accaagcaga 4020 atgagggctt ttctctgaca gccaaaggaa aaggccaagg cacactgtcg gtggtgacag 4080 tgtatcacgc caaagtcaaa ggcaaagcca cctgcaagaa gtttgacctc agggtcacca 4140 taaaaccagc ccctgagaca gccaagaagc cccaggatgc caagagttct atgatccttg 4200 acatctgcac caggtacttg ggagacgtgg atgctactat gtccatcctg gacatctcca 4260 tgatgactgg ctttattcca gacacaaacg acctggaact gctgagctct ggagtagaca 4320 gatacatttc caagtatgag atggacaaag ccttctccaa caagaacacc ctcatcatct 4380 acctagaaaa gatctcacac tccgaagaag actgcctgtc cttcaaagtc caccagttct 4440 ttaacgtggg acttatccag ccggggtcgg tcaaggtcta ctcctactac aatctagagg 4500 agtcatgcac ccggttctat catccggaga aggacgatgg aatgctgagc aagctgtgcc 4560 acaatgaaat gtgccgctgt gcagaggaga actgcttcat gcatcagtca caggatcagg 4620 tcagcctgaa tgaacgacta gacaaggctt gtgagcctgg agtggactac gtgtacaaga 4680 ccaagctaac gacgatagag ctgtcggatg attttgatga gtacatcatg accatcgagc 4740 aggtcatcaa gtcaggctca gatgaggtgc aggcaggtca ggaacgaagg ttcatcagcc 4800 acgtcaagtg cagaaacgcc ctaaagctgc agaaagggaa gcagtacctc atgtggggcc 4860 tctcctccga cctctgggga gaaaagccca ataccagcta catcattggg aaggacacgt 4920 gggtggagca ctggcccgag gcagaggaat gtcaggatca gaagaaccag aaacagtgcg 4980 aagacctcgg ggcattcaca gaaacaatgg tggttttcgg ctgccccaac tgaccacaac 5040 ctccaataaa gcttcagttg tattttaccc atcaaaaaaa aaaaaaaaaa a 5091 <210> 37 <211> 1500 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1500) <223> Capg <400> 37 ggggctttcc ttgcccatct gactttaaat tgctcagaat ttgccttgcc tgaggctgct 60 gtgatgagac cctgtcaggc tttaaccttc cagtggtcgt gtccgggaaa gggcagtctt 120 ccatcagcat ggctcagtct tggagcttgc tttccagaat cttagacctc tgagttctga 180 gcctccccat gggtggggca ggtgggcggg acagcccagt ggagaagagg gaagtcagaa 240 gccagcgtgg ggcaggctga gactagtcgg agaagaaaag gccggtggag aggtctgaaa 300 acagcatgta cacgcccatc cctcagagtg gctctccatt cccagcctca gtccaagacc 360 caggcctaca catatggcgt gtggagaagc tgaagccggt gcccatagca cgagagaacc 420 atggcatctt tttttctggg gattcctacc tagtgcttca caatggcccg gaagaggcct 480 cccatctgca cctgtggata ggccagcagt catcgcgcga tgagcagggg gcctgcgctg 540 tgctagctgt gcacctcaac accctgctgg gggagcggcc tgtgcagcac cgtgaggttc 600 aagggaacga gtccgacctc ttcatgagct acttcccaca aggcctcaag tatcgggagg 660 gtggcgtgga gtcggcgttc cacaagacaa cctcgggcac cacgccagca gccatcagga 720 agctctacca ggttaagggg aagaagaaca tccgtgcgac cgagagggct ctgagctggg 780 acagcttcaa cactggggac tgcttcatcc tggacctggg tcagaacatc tttgcctggt 840 gtggtggcaa gtccaacatc ctggagcgca acaaggcgag agacctggcc ctggccatcc 900 gggacagcga gcggcagggg aaggcccagg tggagatcat cactgacgga gaggagccag 960 ccgagatgat ccaggttctg ggccccaagc ctgctctgaa ggagggcaac cctgaggagg 1020 acattacagc ggaccagacc aacgcccagg ctgcagccct gtataaggtc tctgatgcca 1080 ctggacagat gaatctgacc aaggtggctg actccagccc gtttgcctct gaactgctaa 1140 ttccagatga ctgctttgtt ctggacaacg ggctatgtgg caaaatctac atctggaagg 1200 ggagaaaagc caatgagaag gagcggcagg cggccctcca agtggctgat ggcttcatct 1260 ctcgaatgag atattcccca aacactcagg tggagattct gccccagggc cgagagagtc 1320 ccatcttcaa gcagttcttc aaggactgga agtgagggtg ggtgtcccca tccctgctct 1380 cctgccccca ccacctgcct gcttgtttcc cctctggctg ctgagtcaga actgaggggc 1440 cctctggatg ctcaataaag gacacgttct gttcccaaaa aaaaaaaaaa aaaaaaaaaa 1500 1500 <210> 38 <211> 2091 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2091) <223> Creg1 <400> 38 gcaggtgctc tgcagtcagc gccatggctg cccgcgctcc tgagctcgcg cgctccctgc 60 ttgctgccct tctggctccc gcgctagtgg cactactggt gtcgccggcc tggggacgcg 120 gaggccggga ccacggggac tgggacgtgg acaggcgact gcctccactg ccaccccgcg 180 atgacgggcc gcgcgtggcc cgcttcgtga ctcacgtctc ggactggggc tcgctggcca 240 ctatctccac gagagaggag gtgcgcggca ggcccttcgc ggacatcatc tcaattagtg 300 acggtcctcc gggagaaggc tcaggcgagc cctacatgta cctgagtccg ctgcaacaag 360 cagtgagcga cctgcaggga aatccagagg ctacgctgac tatgtcttta gcacagactg 420 cctactgtag gaaccatgga tttgatcccc agagtcccct ctgtgttcat ataatgatgt 480 ccgggactgt gatcaaagta aatgagacag aagagggcta cgcacgggac tcgctattca 540 tcagacaccc tgagatgaaa cactggcctc ctagccataa gtggttcttt gctaagttaa 600 aaataagcaa tatctgggtt ttggactact ttggtggacc gaaagtagtg acacctgaag 660 aatattttaa cgtcacactg cagtgaagca aatacggtga actggatcac accagcgaca 720 ggtcttccaa ggctcatgca cacagagggc tcgaccctgc ctggctgcta gcccactctg 780 ccacctcttg tttcgatttc ctttgcttgt ctttgcagag tgttgtccat tagaagacgt 840 gcttgctgga tttaaaaaaa aaaaaaaaag tcttgaagcc attttcagag aaaaatgccc 900 ttctttatga tcaaggaagc catgctcggt gctttttcct cagtggtgcc ctcagtaggg 960 tgacatatac cagctgtaga ccgcccattg gcactggagg tccagaggtg cagatgctct 1020 gtgcctgatg gccactgtgc ctgaaggtgc tgtgctcacc cagctgcctc aggagccagt 1080 gcagaggggc cgtatgaatc ctccagtcca ggacagcagt gaccacggat gcagcgtccc 1140 attcacgtca acctgtatag ctgatcagca caaggcaaag ctgggtcttc tgtaaaactc 1200 cataaacgtc ttacattcta aagtcatcgt tacccagaac aaaataaatc agaaagattt 1260 tcctgcatcc attctccatc taagtagact gtacactcac tcctcatcct tcggaatgtg 1320 cacgcctgag ctggggcgca gctttcttgg cacagagctt gccaagcatg aatgggacca 1380 taacgtcgaa acaaccagcc agccacagac gacatcttta tgtgcatgaa aaagcaacct 1440 cagaagaaaa aggatttcgc atatgttggg ctctttttcg taagacttaa ccctgtgcca 1500 gccgcaatcc aagccctcct ccggcattct gtatcttgaa gctcctggtg ctgccgcctg 1560 cgtcctctgt gggatgtacc acggtactgt ggcataaaaa caaactacaa caacaacaaa 1620 acatgtctct gcaccagagg atggctcagc ttgtaagatg actgctctag cagaggaccc 1680 aagttcagta cccgcaaggg gtcagacagg cacatatgcc cagaactcca gctccaggag 1740 atcaaatacc tctagcctcc aaggtcacct gcactggaat acacacaccc acacatagac 1800 acacagcgac acaatttcaa acagtacatc ttttattcca aagaggtact acttagttta 1860 attacctgtt tcatgctctt ggatgacata agatttcttt taacagagtg tgggggaatc 1920 aagacactga cttaaacagc caaaaaaaaa aaaaaaaaag ttaactatga accatcatgt 1980 tggagaaaga gatggtaatc ataacagaaa tccagcaaac gacgtctcag tcaaaaccca 2040 ctaaacagta aggatcttgt tattgaaatc agtaattaaa agcattatta t 2091 <210> 39 <211> 948 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(948) <223> Lgals3 <400> 39 aacagctagc ggagcggcag gaggagcact aaccaggaaa atggcagacg gcttctcact 60 taatgatgcc ttagctggct ctggaaaccc aaaccctcga ggatggcctg gtgcatgggg 120 gaaccagcct ggggcaggag gctacccagg ggcctcctat cctggggcct acccaggaca 180 ggctcctcca gggggttatc ctggacaggc tcctcctagt gcctatccgg gcccaactgg 240 ccctagtgct tatcctggcc caactgcccc tggagcttat cctggcccaa ctgcccccgg 300 agccttccca gggcaacctg ggggacctgg agcctacccc agtgctcctg gggcctaccc 360 cagtgctcct ggggcctatc ctgctactgg cccctttggt gccccgactg gaccactgac 420 agtgccctac gatatgccct tgcctggagg agtcatgcct cgcatgctga tcacaatcat 480 aggcacagtg aagcccaacg caaacagtat cactctgaat ttcaagaaag ggaacgacat 540 cgccttccac tttaaccccc gcttcaatga gaacaacaga agagtcatcg tgtgcaacac 600 gaagcaggac aataactggg gaagggaaga aagacagtca gctttcccct ttgagagcgg 660 caaaccattc aaaatacagg tcctggttga agccgaccac ttcaaggttg cggtcaatga 720 tgttcatctg ttgcagtata accatcggat gaagaacctc agggaaatca gccaactggg 780 gatcattggt gacataaccc tcaccagcgc ttcccacgcc atgatctaag ccagaagggg 840 tgggccggca ccagaactgc cctgtgtgtt atgagcggga aactttgcat ttctctctcc 900 ttatacttct tgtaagacat ccatttaata aagtctcgtg ctgagaga 948 <210> 40 <211> 1156 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1156) <223> Acyp2 <400> 40 cgcagagagg gagctccctg cttgggagct ggagcgcccg gtgtcctgcc gtcctcacta 60 cggactgcgg actgcggtgt cctgtggtct tgcgtgaccc ggcgcgtacc cgtcctgcca 120 ggcgtcggtc ccagagccca tgagcctcct tcgcctggcg tctgtcgcac tctccgcacc 180 acacaccccg ctacggctgc tcgcgagagg gctggccgcc atggcggagc cgcttaagtc 240 tgtggactac gaagtgttcg ggacagtgca aggtgtttgc ttcagaatgt atacagaagg 300 agaagctaag aaaagaggtc tggttggctg ggtgaagaat acaagcaaag gcacagtgac 360 aggtcaagtt caaggccctg aagaaaaggt caattccatg aagtcctggc tgagcaaggt 420 tgggagtcct agttctcgca tcgaccgggc cgacttttct aacgaaaaaa caatctctaa 480 actggaatac tctaatttta gtattcgata ttaataaaag aaagagatca attgcaatgc 540 ttatattata gaagataaaa catattctta ggtttataat agtaggcgag taggattaaa 600 aatggaaagt ttttgttctg gaattataca ttactgaaat ttctgaaact gaaaaacttt 660 actcacctat gttttagcaa gcagaaacta aatattataa aataaaatgt cattataaat 720 tatctagtat gaacattcaa gttaaatatt gtcttatgga gtcattcatt tcagaaaata 780 ttacagtatt tgttacttta tattacatta tatatgttat ttggctagac ataaaataaa 840 attaactatg taaaattacc tatggatact gttgcctaat tgacttttaa agtcctctga 900 ataataactt actattaagg ttgagcgatt agccttaaaa attgttaaaa taaattcgtg 960 tgatgatcac cataaccaga aagtactagc aatagacagt tagtgtgtaa acttctcctt 1020 aaactcaagc ctggttcagt acaaagttgg acttacttac tatccttgac ttaattgttc 1080 tgtagtttga agagtgttgt tgtaaaaata taaaaaataa aagagtattg gtgtctttta 1140 aaaaaaaaaa aaaaaa 1156 <210> 41 <211> 3032 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3032) <223> Arc <400> 41 agtgctctgg cgagtagtcc tccctcagcc gcagtctctg ggcctcttca gcttgagcgg 60 cggcgagcct gccacactcg ctaagctcct ccggcaccgc gcacttgcca ctgccactgc 120 cgcttcgcgc ccgctgcagc cgccggctct gaatccttct ggcttccgcc tcagaggagt 180 tcttagcctg tcccgaaccg taaccccggc gagcagatgg agctggacca tatgacgacc 240 ggcggcctcc acgcctaccc tgccccgcgg ggtgggccgg ccgccaaacc caatgtgatc 300 ctgcagattg gtaagtgccg agctgagatg ctggagcacg tacggaggac ccaccggcat 360 ctgttgaccg aagtgtccaa gcaggtggag cgagagctga aagggttgca caggtcggtg 420 ggcaagctgg agaacaactt ggacggctat gtgcccacgg gcgactcaca gcgctggaag 480 aagtccatca aggcctgtct ctgccgctgc caggagacca tcgccaacct ggagcgctgg 540 gtcaagcgtg agatgcacgt gtggagggag gtcttctacc gtctggagag gtgggccgac 600 cgcctggagt ccatgggcgg caagtaccca gtgggcagcg agccggcccg ccacactgtc 660 tctgtaggtg tggggggtcc agagccctac tgccaggaag ctgatggcta cgactacact 720 gttagcccct atgccatcac cccgccacct gccgcaggag agctgcctga gcaggagtca 780 gttggggctc agcaatacca gtcttgggtg ccaggtgagg atgggcaacc aagcccaggt 840 ctggataccc agatctttga ggacccacgg gagttcctga gccacctgga agagtacctg 900 cggcaggtgg gtggctctga agaatattgg ctgtcccaga tccagaacca catgaatggg 960 ccagccaaga agtggtggga gttcaaacag ggctcggtga agaactgggt ggagttcaag 1020 aaggagtttc tgcagtacag tgagggtacg ctctcccgcg aagccattca gcgggagctg 1080 gacctgccac agaagcaggg tgagccactt gaccagttcc tctggcgtaa gcgggacctg 1140 taccagacac tgtatgtgga cgctgaggag gaggagatca ttcagtatgt ggtgggcacc 1200 ctgcagccca agttcaagcg ctttctgcgc cacccacttc ccaagaccct ggagcagctc 1260 atccagaggg gcatggaagt tcaggacggc ctggagcagg cagctgagcc ttctgtcacc 1320 cctctgccca cagaggatga gactgaggca ctcacgcctg ctcttaccag cgagtcagta 1380 gccagtgaca ggacccagcc tgaatagagg ggccagccca gggtccccag cctgcctgcc 1440 acacccagtc tgtggctttt gtcaactagg acttgattga gctggggctg acacccaagg 1500 ggatgccctg tccagccaga caccttctca cccactggcc tgactcacaa ctgccacaca 1560 accatgattc atggacatca agaagcccct ctcccatagg gctcccacct gccacctacc 1620 cctcacctgt ctgccctagt cctggccctg tctccagtgg cctcaccctc tacactctca 1680 gaccatcaca gaacaccttt ggcttcctca ttctgcatca gtgtccaggg ccctttgggt 1740 agtcaagaaa tcaagtgtct gaaaggcaat gaaaagtagg caccaaaccc aaggggcatc 1800 ccagggcaga tgctaaagca gaatcagaga tggccgaagg aacctctact tccggggatg 1860 cagcccgctc ctacagacac agcagatcca gctggtgccc tacctgcctc ccagagcaac 1920 tggccagtct tgggcagcat agctcccctc tcagggtgag ctgaagcagc agacctgacg 1980 cgctggcgcc tcctggcccc cagcagtgat tcataccagt gaagaaaagc agacttcggc 2040 tccatgactc agccatgcca ggcggagggt cccagagggg ctgagtcctc agccccagct 2100 gaggcagcag ctggagtctt cagagccagg tgaatgacac caggtctcaa gctgctgaga 2160 agtctttccg gccatgtctg gaaggggtac caccccagca ccagcaccgt cccctcctct 2220 cttgaagctg cctgcacaga ggttccaaga cactttcaag gcagagaaaa taggattaca 2280 aagaggaggt gccttggcag agggcagcac ccagctcagc ctcagagctg aaggtgaaga 2340 caagccagcg tgaaaccccg ggtctgccac gaatgcccgc tccgctggcc actcaccagc 2400 tgcctgccac aagccactgc agcttgagca gggtctgtgc cctctcagca cagagcccag 2460 ttcgctgcgt ggcctttggc ccccgccaga accttgcagg agccttaagg ttcgggccct 2520 agcccagcct gaccttacct gctgtgccct gcctgctggt caagtccagt cccaggagac 2580 cccatgcctt ggctcctagg ctgttccagg cacttccctg acctgccggg tgattgccca 2640 gctggaacct catccacacc ccagcaccaa ccacctcgtg ttggtaactg ctcgtgtctg 2700 tagtctgagt aggccatgtt gaggttcctc catctgcctg gtccattggt gttctgagac 2760 cagttccact gctgttctga cagatccccc accctgtgcc cctgccagcc cccacaggtt 2820 tatttttgca cataaaccat gacccatact aatttggcta gctctgggga ctagggagac 2880 cctggagatc tcaagagtgt ggctatcccc tattttcacc aagccttcaa tatccagcca 2940 ggccatctgg cccacaccat cttacctcaa agacagacat atatatatat atacatatat 3000 atgattttgt taataaaact atgaaattta aa 3032 <210> 42 <211> 2535 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2535) <223> Csrnp3 <400> 42 atggatggtc gagggcggag tgagctcttc tcagtgtgtt ctgccggagc ccaagtacag 60 agaccatatt tacaggtcca agtgacagct atgagtggaa ttttaaaggg gaagctggaa 120 gaagctgaca gcgcctctct ctgctcttcg gggcaggaat cagatgatga cgtttttagc 180 tgttacagtg ctgacagtct tgatagtgtc tgtctgtcca cagctggtca tttacccgaa 240 aaaataaaag gatatcagca gcctgaaagg atattctcag aagcatagac tcttcggagg 300 atactgaact tcatgagatc tcacggtaca tgtgacagcg ccgcagctat gagtggaatt 360 ttaaagagga agttcgaaga tgtggaagcc tcctcgccct gctcctctgc tcgggaatcg 420 gatgacgaag tctccagcag cgaaagtgct gacagcgggg atagcgtcaa tccatctacc 480 tccaatcact tcaccccttc ctccatcctc aaaagagaga aacggctgag gacgaagaat 540 gtgcacttca gttgtgtcac cgtgtactac ttcaccagga ggcagggctt caccagtgtg 600 cccagccagg gtggcagcac tcttgggatg tccagccgtc acaacagcgt gcgccagtac 660 accctgggag agttcgcaag agagcaggag cggctgcacc gggagatgct gagagaacac 720 ctcagggagg agaagctcaa ctctctaaaa ctaaagatga ccaagaatgg cactgtagaa 780 tcggaggaag cgagcacact gaccgtggat gacatttccg atgacgatat cgatttagac 840 aacacggaag tcgacgaata cttcttcctg caacccctgc ccacaaaaaa acggagagct 900 ctgttgcgag cctctggggt gaagaagatc gacgtggaag aaaaacacga gctgcgggcc 960 atccgcctgt ctcgggagga ctgcggctgt gactgcagag tgttctgtga tccagaaacg 1020 tgtacctgca gcctggcagg cattaaatgt caggtggatc ggatgtcttt cccatgtggc 1080 tgcactaaag aaggctgtag taacacagca ggtagaattg aatttaatcc tatccgcgtg 1140 cggactcatt ttttgcacac aataatgaaa cttgaactgg agaagaaccg agagcagcaa 1200 acccccacgc tgaacggctg ccacggggag ataagcaccc acggcccttc catgggccct 1260 gtcgctcact ccgtagaata ttccatcgca gacaatttcg agattgaaag cgagccccag 1320 gctgcagtgc tgcacctgca ggaggagctg gattgccaag gagacgagga ggaggaggag 1380 gaagacggaa gcagtttctg cagtggagcc actgactcga gcacccaaag cctggccccc 1440 agtgaatcag acgaggaaga ggaagaggag gaggaagagg aggaagagga ggaggaagat 1500 gacgacgacg acaagggaga cggctttgta gaagggcttg gagcccatac tgaagtcgtc 1560 ccccttcctt ctgtcctttg ttactccgat ggtactgcag ttcatgaaag ccacacaaaa 1620 aatgcttcat tttacgctag ctcttcaact ctgtactacc aaatagacag tcacattccg 1680 ggaactccta gccagctttc tgacaactat cctgaaagag atactgtcaa aaacggtgcc 1740 ctttcgctgg tgccttacgc catgacccca gagcgctttg ttgactatgc caggcaagca 1800 gaagaggcct atggagcctc tcactaccca gctgccaacc cgtcggtcat tgtttgctgc 1860 cccacctctg aaaacgatag tggggtgccc tgtaacccct tatatcctga acacaggtcc 1920 aatcttcctc aagtggaatt tcactcatac ttgaaaggcc cttcccagga agggttcgtc 1980 tccacattga atggcgacag ccacatttca gagcatcctg cagaaaatcc tttgagcctt 2040 gcagaaaaga gcagattgca tgaggagtgc attcaatccc ccgtggtgga aacagtcccc 2100 gtttagttgc ttaaattatt ctattataga ccaagtcttc tatttaaggc actgtattgc 2160 ctttgctggc gttgtttaac ccgaagacca agaatatgtg gactgtgatt aatctttcag 2220 acagtatttc cttccttcct ttctaggttc ccaactgtgg cgtggcacaa aatacagtcg 2280 ctatggggat tttaaacgat tttgaactgt tttgatagaa aatgctaaat taaaaaaaaa 2340 aagcatatct cacagttgcc tacctgtcaa actgtgtgaa acctgccaag ctatgcagac 2400 catagctcca agttttagat tatcgggcct gtgcaagatt gttaactaag actagaacgc 2460 aagcagattt agagtcctaa tttttcgata tatctgaaga tgatggtgac tttttaaatg 2520 taaaagtaat tattg 2535 <210> 43 <211> 2976 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(2976) <223> Egr2 <400> 43 gcgattcatt aattgctggg cgaggggaca cactgactgt tataataaca ctacatcagc 60 aactcctggc tccccaacag ccggatccca ggcaggagag agtcagtggc agatagccat 120 ttttttttct tccttaagaa gccaacaact tggttgctag ttttatttct gttagaattt 180 ttttttttgt gtgtgtgtgg atgtgtggtg gtggtggtct tttctaagtg tggagggcaa 240 aaggagatac catcccaggc tcagtccaac ccctctccaa aaacggcttc tctggcactc 300 caggtagcga gggagttggg tctccaggtt gtgcgaggag caaatgatga ccgccaaggc 360 cgtagacaaa atcccagtaa ctctcagtgg ttttatgcac cagctgcctg acagcctcta 420 cccggtggaa gacctcgccg ccccgtcggt gaccatcttc cccaatggtg aactgggagg 480 cccctttgat cagatgaacg gagtggctgg agatggcatg atcaacattg acatgaccgg 540 agagaagagg cccttggatc tcccatatcc gagtagcttc gctcccatct ctgcgcctag 600 aaaccagacc ttcacttaca tgggcaaatt ctccattgac cctcagtacc ctggtgccag 660 ctgctaccca gaaggcatca tcaatattgt gagtgcgggc atcttgcaag gggtcacccc 720 tccagcttca accacagcct cttccagcgt cacctctgcc tcccccaacc cactggccac 780 gggacccctg ggtgtgtgta ccatgtccca gactcagcct gaactggacc acctctactc 840 tccaccacca cctcctcctc cttattcggg ctgtacagga gacctctacc aggatccttc 900 agcattctta tcgccgccac ccaccacttc cacctcctct ctggcctacc agccacctcc 960 ttcctaccca tcccccaagc cggctatgga cccaggtctc attcctatga tcccagacta 1020 tcctggattt tttccatctc cgtgccagag agatccacat ggcgcggctg gccctgatcg 1080 aaagccgttc ccctgccctc tggactccct gcgggtcccc cctccgctca cgccactctc 1140 caccatccgt aattttactc ttggggggcc cagtgctggc gtcacgggac caggggcaag 1200 tggaggcggt gagggtcccc gactgcctgg cagtgggtct gcagcagtga ctgctacccc 1260 ctacaatccg caccacctgc ctttaaggcc catcctgaga cctcgaaagt accccaacag 1320 gcccagcaag acgccagtgc acgaaaggcc gtacccctgc ccagcagagg gttgcgacag 1380 gaggttctca cgctctgatg agctgaccag gcacatccga atccacaccg gtcacaagcc 1440 cttccagtgt cggatctgca tgcgaaactt cagccgaagt gaccacctca ccactcacat 1500 ccgcacccac accggggaga agccctttgc ctgtgactat tgtggccgta agtttgcccg 1560 gagtgacgaa aggaagcgcc acaccaagat ccaccttcgc cagaaggaga ggaagagcag 1620 tgccccctcg tcatctgcat ccgcccagtc ttcagcctct ggtcctgggg gctcgcaggc 1680 cgggggcagc ctgtgcggta acagcgccat tggaggacca ctggcctcct gcacctctcg 1740 gaccaggacc ccgtgagatg aagctccagc tgacacacca gtttcttcag gccccagagg 1800 ccctctatcc actcgagctg caaacactac cgcccttctg tgttcttccc cgtgatcccg 1860 tgaacctgtg atcctgggca aaggacccta atggagccca gctctgtccc accttctcac 1920 agacggcctt ctgaaaactt aggccatttt aaaggagttg actgtcactc caagaaatgg 1980 ggagccagaa gagggctggg cgagggcccc tggcctacag ggctgtgctc taaccctgac 2040 agagagatgt ttgactatgg tctgcgagcc cttccctttg accctcgatg ccagttgctc 2100 tgagactttt tctacaatag gttgggagtt gttgattcct ttgagcaagg acagcgaaaa 2160 agactaaatt aaagcaaaac cgatgtggca ctttaatggc ttgggacgga cttggggtag 2220 gggtgggggg ttgtacagtg agcacagttt agccctggcc tggccgcagc actctgtggc 2280 cctagaacag tgaatggaag tttctcgagc catctcagcc cttaagcaat atgtcctata 2340 aactcaagag aacgaacgga agtgcaatgt cgggaaggac aaagcaatat tggctccttt 2400 ttgttgagaa acaaagatta tttttccagt gtatatccat ttagattttt gtgtattttt 2460 tttttttgat gtgcactgtt ctccgagttc tgaacctttg ggaaaaaagt gtaaaacatt 2520 tatgatctct tgaatcgagt caaaagttaa cttatttaaa ggggggtgta cataggatgc 2580 atgcagtggt gttgcaagtg tcctctgtgc cttgtgtgat gtgggcagtg ttacagggtc 2640 tgcatgtgta caggatgcct tactatgaaa aaaaaatcac tccctgggtt taagtatggc 2700 tgtatatttc tgcctattaa tatttggaat ttttttagaa agtatatttt tgtatgctct 2760 gttttgtgac ttgaaagtgt taccttcgca gtcaaatttc agatgagagt gtgcttaacg 2820 tcactgcagc tgacttgttt ggttattagc tcttaatagt tgtggaaaga ttaaacaatc 2880 tattctaaca cagaaccact aactggagtt cagatatcgg acggcttatg gcaatggtgt 2940 aaaataaata cttttcaaca ataaaaaaaa aaaaaa 2976 <210> 44 <211> 3194 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3194) <223> Fos <400> 44 cctccctcct ttacacagga tgtccatatt aggacatctg cgtcagcagg tttccacggc 60 cggtccctgt tgtcctgggg ggaaccatcc ccgaaatcct acatgcggag ggtccaggag 120 accttctaag atcccaattg tgaacactca taggtgaaag ttacagactg agacgggggt 180 tgagagcctg gggcgtagag ttgatgacag ggagcccgca gagggcattc gggagcgctt 240 tcccccctcc agtttctctg ttccgctcat gacgtagtaa gccattcaag cgcttctata 300 aagcggccag ctgaggcgcc tactactcca accgcgattg cagctagcaa ctgagaagac 360 tggatagagc cggcggagcc gcgaacgagc agtgaccgcg ctcccaccca gctctgctct 420 gcagctccca ccagtgtcta cccctggacc cctcgccgag ctttgcccaa accacgacca 480 tgatgttctc gggtttcaac gcggactacg aggcgtcatc ctcccgctgc agtagcgcct 540 ccccggccgg ggacagcctt tcctactacc attccccagc cgactccttc tccagcatgg 600 gctcccctgt caacacacag gtgagtttgg ctttgtgcag tcgccaggtc cgcgctgggg 660 gtcgccgagg agggcacatt ggggtgtgac tgtcagggaa gagtaggggt cttccttgtt 720 tgctccggag ggagactggc gcggtcagag cagccctagc ctgggaaccc aggacttgtc 780 tgagcgcgtg cacacttgtc atactaagac ttagtgaccc ccctcccgcg cggcaggttt 840 actctgagtg tcctgcgctc ttctctcggt gacttgtttc tgagatcagc cggggccaac 900 aagtctctag caaagactcg ctaactagag cctgggaggc ggcaaacggc ggcaatcccc 960 cctcccgggg cagcctggag cagggagaag ggaggaggga ggagggtgct gcgagccggt 1020 gtgtaaggca gtttcattga taaaaagcga gttcattctg gagactccgg agcagcgcct 1080 gcgtcagcgc agacgtcagg gatatttata acaaaccccc tttcgagcga gtgatgctga 1140 agggataacg ggaacgcagc agtaggatgg aggagaaagg ctgagctgcg gaattcaggg 1200 gaggatagag gatattggga gaccttttta tctcggatga agtgcataca ggaagacaca 1260 agcagtctct gaccagaatg cttctctctc cctgcttcat gcgacactag ggccacttgc 1320 tccacctgtg tctggaacct cctcgctcac ctccgctttc ctctttttgt tttgtttcag 1380 gacttttgcg cagatctgtc cgtctctagt gccaacttta tccccacggt gacagccatc 1440 tccaccagcc cagacctgca gtggctggtg cagcccactc tggtctcctc cgtggcccca 1500 tcgcagacca gagcgcccca tccttacgga ctccccaccc cgtcgaccgg ggcttacgcc 1560 agagcgggag tggtgaagac catgtcaggc ggcagagcgc agagcatcgg cagaaggggc 1620 aaagtagagc aggtgagtag cgattctgga cctgcgcggg gagttggggg ggggcggggg 1680 ggacggacgc acaggcgaca cggcagagtg ggtgaaaccc tacgctactg actgcacttc 1740 ctgaccaggg accgtggctg cagccctttc ccaccctcgt cagacactga cagttggccc 1800 caagaaatac tctagtttcc ctgacagctt ccaaccacat tctctagctt gggagcttct 1860 ttgttcccct cctaaagatc tcactttaaa tgcaaatcac actcagcctg ccaactgcag 1920 gttagaaaaa ctgcttcacc gtgagaggtg cgggtgctgt aggagccagt ttcactgggg 1980 tgactgaaca gaggtgacac tagaccacct tattgaatgt tggtcctttt cttatagcta 2040 tctcctgaag aggaagagaa acggagaatc cgaagggaaa ggaataagat ggctgcagcc 2100 aagtgccgga atcggaggag ggagctgaca gatacgctcc aagcggtagg ttgaaccagc 2160 tgctgctcct gaaactttat taaagttgga ggttgggact atggggtcag ggtccttgag 2220 gaaacctgtg tcttatgctt tcttacatct ctgtgcagga gacagatcaa cttgaagacg 2280 agaagtctgc gttgcagacc gagattgcca atctactgaa agagaaggaa aaactggagt 2340 ttattttggc agcccaccga cctgcctgca agatccccaa tgacctgggc ttcccagagg 2400 agatgtctgt gacctccctg gacttgactg ggggtctgcc tgaggctacc accccagagt 2460 ctgaggaggc cttcaccctg cctcttctca atgaccctga gcccaagcca tccttggagc 2520 cggtcaagaa cattagcaac atggagctga aggctgaacc ctttgatgac ttcttgtttc 2580 cggcatcatc taggcccagt ggctcggaga ctgcccgctc tgtgccagat gtggacctgt 2640 ctggttcctt ctatgcagca gactgggagc ctctgcacag cagttccctg gggatggggc 2700 ccatggtcac agagctggag cccctgtgca ctcccgttgt cacctgcact cccagctgca 2760 ctacctatac gtcttccttt gtcttcacct accccgaggc tgactccttc cctagctgcg 2820 cagctgccca ccgaaagggc agcagcagca acgagccctc ctctgactca ctgagctcgc 2880 ccacactgct agccctgtga gcagtcagag aaggcagggc agccggcact gactgagctg 2940 gtgcattaca gagagaagaa acaagtcttc cctcgagggg ttcccgtaga cctagggagg 3000 accttatctg tgcgtgaaac acaccaggct gtggacctca aggacttgaa agcatccaca 3060 tctggactcc agtcctcacc tcttccggag atgtagcaaa aaaacaaaaa aacaaaacaa 3120 aaaaaaaaca aaacaaaaaa tcaaaagcaa ccgcatggag tgtattgttt gtagtgacac 3180 ctgagagctg gtag 3194 <210> 45 <211> 4257 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(4257) <223> Gatsl2 <400> 45 tccccccccc cccaactcgg gccaccgcgg atgatccgcc gtggaggaac cctgggcgga 60 cgatggaact gcacattctg gaacaccggc tgcaagttgc cagcgtcgcc aaggagagta 120 tcccgctctt cacctacggc ctcatcaaac ttgccttcct gtcttccaag accaggtgca 180 agtttttcag tctgacagag acccctgagg actacaccat cattgtagat gaggagggct 240 tccttgagct gccctcctca gagcacctga gcgtggctga tgccacctgg ctggccctga 300 atgtggtgtc cggtggcggc agcttctcca gttcccagcc catcggtgtg acaaagatcg 360 ccaagtctgt catcgctcca ctggccgacc agaacatctc tgtgttcatg ctctctacct 420 accagactga cttcatcctg gtgcgagagc gtgacctgcc cttcgtcact cacaccttgt 480 cctcggaatt caccatcctt cgtgttgtca atggagaaac ggtagcggct gagaatctca 540 gcatcaccaa tggctttgtg aagcctaaaa tggtccagag gccagtcatc cacccactct 600 ccagcccaag caacagattc tgcgtcacca gcctggaccc tgacacgctg cccgccgttg 660 ccaccctcct catggatgtg atgttctact ccaatggagt gaaggacccc atggcttcca 720 gtgacgactg tggccacatc cgcttcttct ctttctcact cattgagggt tacatctcac 780 tggtgatgga tgtgcagacc cagcagaggt tcccgagtca tttactattc acgagtgcat 840 ccggagagct ctggaagatg gtgcgaatag gaggacaacc cttgggattc gacgagtgtg 900 ggattgtagc ccagatctcc gagcccttgg cagctgcaga catcccagca tattacatca 960 gtactttcaa gttcgaccat gcgttggttc cagaagagaa tatcagcggg gttatccatg 1020 ccctgaaggt cagtcaagca gggaagcatt agaaaagact cgtctctggg ctcctccctg 1080 ccacagcccg cctgggcctt tcccccccac gaaggttatt cttgcagtat ttccctatgg 1140 actgaaagct cagccccagg acctttaagg aaggggcctc tgggacactc ccctgattcc 1200 tgactcctcc aggcctgggc ctaaactagg gccaccaccc cccatcttcc tcctgcctac 1260 cagagtcccg gccttttcaa tcatgaccca gtttcccatc agtgaggata tgcccatctt 1320 cctcccccag gttccacccc agaaagtggt ctctgaggcc cagggtactt gggaacagcc 1380 caaggcctca cattcagccg gcagcaaacg ccaaaggaag ctggcacctc ctgtgagaca 1440 ttgggattgg ggtcctgatg cacctaggga catcttagga agttggtgga gcaagatcag 1500 gggggcagag ctggggaagc ccccgtgagg cccccgggtt tgatggttat ggttgccact 1560 tgggagccgg ctccctcaga atggaggcca gcaggccacc ctcaggtcat aatggccggt 1620 gagtctcaga cagaagcagt ggggtcccta cccctaagct ggggaggaaa accaagaccc 1680 tagaacccca cctgctgacc acacagggcc tgtgtcgatt tcctctacaa ctgccaagag 1740 gggacctggg cctaacttcc ccccaacccc cagagcactt gtccctggag gggatcccag 1800 gacacctcct ctcccaccag cctagagtgc cagcttctat ctgtccttcg tccgctctcc 1860 caagacccaa catgggcaaa caaagacttg gcttctccca gcaacgggca tcccgacctg 1920 cccaggccta gagtgccctg ggctatgtcc cacctcccca gctgtcactt agaccagcgt 1980 agagaatccc ccttcatcct ctctacccac ttttagggga caaaaaggca tcagcctccc 2040 ctcccccgca gctcataggc ctgcccaaaa tacacatgca gcagtctgtg gtcaaggtga 2100 tgcctgggag gcagccatct tggagcgttt gtagagagaa attacacttg cgggtttctt 2160 ctttgttgtg tttgcataca ggtggctggg gaaagagtgg ttttgtttgg gagagacggg 2220 gcctgtttga gtctcactag ggtgcccagg gttcgagtga gacttagcac cctgtgtgtc 2280 tccagggaca gacaccagtg caaagatgta tcttaagaat cgtggctatg tcttctgagg 2340 agggctgttg ggagcagagc tcaccaggac cccacagcac cccctacagg gcatcccagt 2400 gtactgccat ctgcatgtgg caatgtggct gggactgagg ggtccaccag actttgctct 2460 tggggtgttt tcccaggcct gtactacgca gtctccaaca acaaggtcag aggagggaat 2520 gtttatttag ccctgcacag tcttgtagga actgtttctc tcctcttcta gaaccatgta 2580 gaagctcaga acccagcatg ttaatcaaaa atcgcctctg gttggttttg gtgggtttag 2640 ttttctttct ttctttcttt ttaactcctt ttgcacaaaa cccttaaaac aaccaaattt 2700 tattgttttc ccgtcccaaa tgggaaatgg ccaagtgggc ggggctttat agtgagtgcc 2760 cgccccccgc ccagtcccct ttttctctcc ctggaaggcc ttgattgtcc ggggtgcacc 2820 tctctgtaac cccttctgtc tccttttcca gttatccctt cccaccgtat aagtgtgctg 2880 accccacgtc ccctgcccca tagttgtgtg gcccctcccc tagacttgct aggatgagac 2940 catgtattgt acacacttat aaatacgtgt tttatgtcga tagagatata ttctgtaaat 3000 agcatatata cttaagcaat atatatgtta atatattctg tgtgcgcagg acacaggcaa 3060 gggccccacc tcacgtgcgc gcacacgggg acgtttttga gccaccgtat atttttaatt 3120 caaatatgta ggcaatatga cgattggaaa agccctgggg tcctgaggcc agcccaggag 3180 ggagacagaa ccaacagcct actgcatgtg gggcaggttg agagggccag tgtggtctgc 3240 ttcatagcta ctgtaccccc atttccacag cctatagctg tagatgactt tatcttattg 3300 ggggaggggg cattgatcca gaggagggat ttctgttgtt gtatttttaa cagtggctcc 3360 ttccctcagg gttactccaa aacctttgtc tagtgacccc agcatgtccc cgcctccctc 3420 ctctccgagt cccctcctcc acagaaagct gtagacccgg catcttatct gatttctgta 3480 gttattgttc tgataatcgt tttttgtttt tttttgtttt tttttgtttt tttttttgtt 3540 tttttgtttt tttgtttttg tttttttttt ggtttttttg aggcagggtc tctttatata 3600 gccctggcta tcctggaact ctctctgtag cccagactgg ccttgaattt atagaaatca 3660 gcctgcctct gcctctgcct ctgcctcctg agtgctggga ttaaaggtgt gcgccaccac 3720 acctggctag gtttattttc tttttaatat tattattatg attataataa cttcaagctt 3780 aggaatctca ggttcttttt ccctgctctc ttcctaagcc tgactccgta aggacagaac 3840 accacacatt cccaccattg tgtgtccaga gaagagctgg gcctgggttc tgcctggcgg 3900 cctttcaagg gaccccactg tttagctgca gtgggtcctt ggagtttctg tgttctgtgg 3960 gtggatcggc actaggggat gtgacggtcc ccactgaggc cctctattct tgtgttttta 4020 gtgccctctc tcagcatctt ctggttttat gaaggatcac tccatcccct gctggcccag 4080 cctcagaggg aacccaagtg gcacgcctgt cgccagcaat cagggttccc taggggattt 4140 tctttgtatt tttctgcagt gctgaggaat gtaggcaggg cctcctgctt gagaggcaag 4200 tggctcaccg ggagggtagg agatcccgct gttaagagag gtaaagtttc agggaaa 4257 <210> 46 <211> 3738 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(3738) <223> Map2 <400> 46 tgaatccttc tcatctagca ctgaagtacc atttaggcat gagctcttgg caggagtggg 60 ctctgagcag gtgtcatatt cattctttac aaaccataga taaataatct catcccccaa 120 ctgtagtaat tgttacaatt ttatataaaa aaaaagaata gtatatgcag aaaatgacct 180 gaattccatc cgcaacaaga gcacatggct ttacatggat acaattggac aattattttc 240 gctctgctct gttttgcatg gagtattatt attattatta tttttaaaat tgcattttta 300 cctttcatgt gcctgaaggc tatccaatac attctgaaag gccttgttaa aaatccaagc 360 tgctcatttc cctattctgt ttatggttgg aaagattaaa aactatccat tgtcgcttac 420 tacaggttca aggaaatcaa ggagtctgag tgcaggaagg aaagagcatg taagagacac 480 attttttaaa gtgttatttt gtataaatgg gaagaaagat gcaactaagt tattgatgtt 540 tgggacctgg atgattatat cagagtatgc cgttccaata aattatttaa ctaaaagcta 600 gattaaagca tgtgagcggt gtttgaagaa gtggtgtgga agtgcgtctc ttaggattga 660 tgcactttcg ttaggatggg ctcgagtctg attagaatgt cagttgattg gctagatttg 720 tgtccacaca gtcagtttca tgcccccatt ccatctgttt gatacagtat tatagatata 780 aatatatata tatatttctc tgtggccatt tgtgatactt cctcatatac ttgaatatga 840 tacttcttta ttcacagtat ctgtgtctcc tgcacccttt ggtgttgcaa ttttaggtat 900 gtgaaagtag atgttagcag ggttctctcc ctatttaaaa atacatttta caaagacaaa 960 gagtttgagc atgaagttgc tttctgtaac aactcaaagc tgtaaccctg ttttagtgcc 1020 agaatcaagt ccttcctgtg atgctagaac attttatttt tctttgcttc caccaacatg 1080 gagtttgtgg agtgggtcca gttatgcata aaggggttta cagattgttg gtctatggat 1140 ttatctcatg tttaattact gaatagtttg ggttttatcc ctctaattat tcatgaaacc 1200 aatcccttac tattcatttc ttctctttct cttttccttt ttccatttgc taaagttgaa 1260 agtaggaaaa tagttttgga tatcttttct tgttctccaa atagtatctg ttcattaaat 1320 aattctctga tagaagatat ttggcttcct tctcccaaag acctcttcaa aaatgagaaa 1380 tacaacatat taagaatata tatatatata tatatatata tattctttga gacacagata 1440 tctaaatcca tctctccagg attctacatg aacatggtat gatttttttt attttatata 1500 cagtctcaac atcacaattc attaatttca tttacaaatc atactaagtg aataagcaag 1560 agtcaatggc ccaaaagaag acaaagcatt atcaaaccaa gtggactttt cccttaacat 1620 ttaatttgtt ctttttcttg ttctcaggat tggtagactg aatctgaagg gttaaatgta 1680 aaaagttggc taggtgtttt atgtctttga aacaagccaa gccctgtcta taaaggagac 1740 ggtgaacatg aacaagacag agacgtacag gtgtgtctga gacagaaggc aagtggatgc 1800 gaaggcagag aggaaacagg tggcagttta gtgatccatt gagtattatg gccaatgtga 1860 cagccacatg gaaagcttag catcaaacga agacattctt cacagctagt aggtacacac 1920 acagacacag acacagacac acacacacac acacacacac acacacacac acacacacag 1980 agagagagag agagagagac acacacacac acacagagag agagagagac acacacacac 2040 acagagagag agagagagag acagagagag agagagagac acacacacgt ctttgtaaat 2100 tgttttttta atatataact ttaaaactac catgtaatgg ttgctttcac tctggacaat 2160 ccattcctta cctactcttg aatgcacaag aaatggaaga aggaacgtct gtgtgtggag 2220 aaggccagtc ctacagtttt ggtagacaag gattaaagtt atctaggaaa aagagagtta 2280 atagatgatc cgtgtggttt aaactatgta gaagtaattt caacccagtt tattataaaa 2340 attaaggcta agcaaaggtt tttttaagtg ttcaagttca ttttcttacg atgtgtattc 2400 aaaataaaat tatgtaagcc ccaagttaat agatctagca ctaaaatatc atttttctaa 2460 tgttaataca attataatgg atacaagtcc ttgttctatg tgaaaatgtg attcacacat 2520 gaatgtaaag tcaacacaag aaggacctga attttttgta ccagacagag acagagaaat 2580 gcacaggcta aaattcactt ccttatggga atgtgggatg gatcccacct tacctactta 2640 agataatgac tcaaattaag ctttttggac accacttttg tggggataca catacgctga 2700 tctagaaatg aaaggcgcac agctacattt ctagatccac taatgccagt ttctctttgg 2760 cttcagcctt tgagaacctg ttcaagaata cgtaagtatc cagagctctg aagagttcga 2820 aggccaactt tttcagtgaa ctcacacact ctgggtctcc tgcaactgac aattgggtac 2880 cttgcaacaa tgcgggaagg atccgagttt atgatgagtt tcaaaggccg tgttcactta 2940 ggaactgact ctctctggat ctgcctgctg cgttccagcg agatgacggg ctgaaatccc 3000 acccatagga agacacctgt gcaattccag ctcagtttgg ctgaaggtaa ctaaagaaga 3060 aggtccagta aatggaagaa tagactacag ctggccttct ccacacacac acgcacacac 3120 acgcacgcac gcacacacac agatgtggga tagaagagag atcagcacca aaatgtagca 3180 ttatatcagt agtagtaaag aaataatata aatgtgaatg attctgactt agctgcattt 3240 atagttttct tctcattttt catgccacag ggggaaaaaa ataaattatt tatagtagaa 3300 gtagcaaggc aaaagtagat ttatcatttg gaaaggcaaa tttcaggcat ttcttcaaga 3360 ctggtgtgct aaaattaata ctgttgttgt gtttttacac ctagaagttt tagcctggac 3420 atgtagattg aggccaagtc cctatgtagg aaaaagtttt tttcaaaacc cctaaaaaaa 3480 tgccaatcat gaaagtccac ttcaacttta gcaaaaaaat tcaacaaaaa gtatactctg 3540 tatgctggga tcccaaggtt ccaacacacc atctttgggg gggttctttc ttctgataat 3600 tctagagcct gttaccatag aaaggaattt cttcaatggc tgattgtagt tagttcatgt 3660 ttttcaatca atttgcaaat gtatttgttg ctgtatagtg attgttttgc aaaataaaat 3720 tgcttgtcat ctaactac 3738 <210> 47 <211> 1809 <212> RNA <213> Rattus norvegicus <220> <221> gene <222> (1)..(1809) <223> Pex5l <400> 47 atgtaccagg gacacatgca gggaaaaggc tctagggctg cagataaggc tgttgccatg 60 gtgatgaagg agataccgag ggaggagtct gcagaagaaa agcccctcct tactatgaca 120 tcacagctgg tgaatgagca acaagaaagc agacctctcc tgagcccctc catcgacgac 180 ttcctctgtg aaaccaaatc cgaggccatt gcaaagccag tgacgtccaa cacagctgtg 240 ttgaccactg gcttggatct ccttgacctg agtgaacccg tctctcaaac ccaaaccaaa 300 gccaagaaat cagagtcctc atcgaagagt tcatccctca agaagaaagc tgatggctct 360 gacctcatca gtgcagatgc tgagcagaga gcacaggctc tccgagggcc agagacatca 420 tccttagatt tagatattca aacacaactg gaaaaatggg atgatgtcaa gtttcatggt 480 gaccgaacaa gcaaggggca cctcatggca gagaggaagt catgctcttc cagagccgga 540 tccaaagagc ttctgtggtc ctcagaacat agatctcagc cagagctgag taccgggaaa 600 agtgccctca actccgagtc ggcttctgag ttggaacttg tggctccagc acaggctcgg 660 ctgaccaaag agcatcgctg gggaagcgcc ctgctctcca ggaaccattc cttagaagag 720 gagtttgaga gggcaaaagc agcagtagag tcagatacgg agttctggga taagatgcag 780 gcagaatggg aagaaatggc ccggaggaac tggatatcag agaaccagga agctcagaac 840 caagtcaccg tctcagccag tgagaagggt tattactttc acactgaaaa tcccttcaag 900 gactggcctg gagcatttga agaaggctta aaaagactga aggaagggga cctgcccgtc 960 accatcctgt tcatggaagc agcgatcctt caggaccctg gaaacgctga ggcatggcag 1020 tttcttggta taacccaggc cgagaatgaa aacgaacagg cagccattgt cgccctccag 1080 aggtgcctgg agttgcagcc caacaacttg aaggctctga tggccttggc tgtgagttac 1140 accaatacca gccaccagca ggatgcttgt gaggcgctga agaactggat taagcaaaac 1200 ccaaagtaca agtaccttgt gaagaacaag aaaggctctc caggcctcac gcggcgaatg 1260 tctaaatccc cagttgacag ctctgtcctg gaaggggtga aggacctgta cctggaggct 1320 gcccaccaaa atggtgacat gatcgaccca gacctgcaga cgggtcttgg agttctgttc 1380 cacctgagtg gagagttcaa ccgagcgatc gatgcattta atgctgcctt aactgttcgg 1440 ccagaggatt actcgttgtg gaaccgactt ggggcaacct tggcaaatgg agaccgcagt 1500 gaggaagctg tagaggccta cacgagagca ctggagatcc agccaggttt catccggtcc 1560 aggtacaacc tgggaatcag ctgcatcaac ctgggtgcct acagagaagc ggtcagcaac 1620 tttctcactg ccctcagctt gcagaggaag agcaggaacc agcagcaggt ccctcaccct 1680 gccatctccg ggaacatctg ggccgccctc aggattgcgc tgtcgctgat ggaccagcca 1740 gagctcttcc aggcagccaa cctcggcgac ctggatgtcc tcctgagagc tttcaacttg 1800 gatccttga 1809

Claims (15)

1. 서열번호 1로 표시되는 Atxn7 유전자로 이루어진 바이오마커, 상기 유전자에 특이적인 핵산 또는 올리고뉴클레오티드, 또는 상기 유전자가 암호화하는 단백질에 특이적인 항체를 포함하는, ADHD의 과잉행동, 집중력 또는 주의력 결핍, 및 충동 행동으로 이루어진 군에서 선택된 1종 이상의 증상을 검출하기 위한 ADHD 검출용 조성물.
2. 제1항에 있어서, 상기 바이오마커는 ADHD의 과잉 행동 증상을 검출하기 위한 것인 ADHD 검출용 조성물.
   
3. 제1항에 있어서, 상기 바이오마커는 ADHD의 집중력 또는 주의력 결핍을 검출하기 위한 것인 ADHD 검출용 조성물.
   
4. 제1항에 있어서, 상기 바이오마커는 ADHD의 충동 행동을 검출하기 위한 것인 ADHD 검출용 조성물.
   
5. 삭제
6. 제1항에 있어서, 상기 서열번호 1로 표시되는 Atxn7 유전자는 ADHD에서 발현이 증가되는 유전자인, ADHD 검출용 조성물.
   
7. 제1항에 있어서, ADHD (Attention Deficit/Hyperactivity Disorder) 증상과 관련된 하기 표에 기재된 유전자군으로부터 선택된 하나 이상의 유전자로 이루어진 바이오마커, 상기 유전자에 특이적인 핵산 또는 올리고뉴클레오티드, 또는 상기 유전자가 암호화하는 단백질에 특이적인 항체를 더 포함하는 ADHD 검출용 조성물.
   [표]
   

   

   
   
8. 제1항 내지 제4항, 제6항 및 제7항 중 어느 한 항에 기재된 조성물을 포함하는, ADHD의 과잉행동, 집중력 또는 주의력 결핍 및 충동 행동으로 이루어진 군에서 선택된 1종 이상의 증상을 검출하기 위한 ADHD 검출용 키트.
9. 서열번호 1로 표시되는 Atxn7 유전자 바이오마커의 핵산 서열; 그의 단편인 올리고뉴클레오티드; 또는 그에 상보적인 핵산 서열 또는 올리고뉴클레오티드가 집적된, ADHD의 과잉행동, 집중력 또는 주의력 결핍 및 충동 행동으로 이루어진 군에서 선택된 1종 이상의 증상을 검출하기 위한 ADHD 검출용 키트.
10. 제9항에 있어서, 상기 검출용 키트는 ADHD 검출용 마이크로어레이 칩인 ADHD 검출용 키트.
11. 대상체와 정상 대조군로부터 분리된 RNA 시료 중 제1항에 기재된 서열번호 1로 표시되는 Atxn7 유전자로 이루어진 바이오마커의 발현 정도를 비교하는 것을 포함하는, ADHD의 과잉행동, 집중력 또는 주의력 결핍 및 충동 행동으로 이루어진 군에서 선택된 1종 이상의 ADHD 증상을 확인하기 위한 정보를 제공하는 방법.
12. 제11항에 있어서, 대상체에서 서열번호 1로 표시되는 Atxn7 유전자의 발현이 대조군에 비하여 증가된 경우 대상체가 ADHD의 과잉행동 증상을 나타내는 것으로 판정하는 것을 더 포함하는 ADHD 증상을 확인하기 위한 정보를 제공하는 방법.
13. 제11항에 있어서, 대상체에서 서열번호 1로 표시되는 Atxn7 유전자의 발현이 대조군에 비하여 증가된 경우 대상체가 ADHD의 주의력 또는 집중력 결핍 증상을 나타내는 것으로 판정하는 것을 더 포함하는 ADHD 증상을 확인하기 위한 정보를 제공하는 방법.
14. 제11항에 있어서, 대상체에서 서열번호 1로 표시되는 Atxn7 유전자의 발현이 대조군에 비하여 증가된 경우 대상체가 ADHD의 충동행동 증상을 나타내는 것으로 판정하는 것을 더 포함하는 ADHD 증상을 확인하기 위한 정보를 제공하는 방법.
    
15. 삭제

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