KR101579964B1

KR101579964B1 - Stable non-epispastic vitamin C composition

Info

Publication number: KR101579964B1
Application number: KR1020140076786A
Authority: KR
Inventors: 김병욱
Original assignee: 김병욱
Priority date: 2014-06-23
Filing date: 2014-06-23
Publication date: 2016-01-04

Abstract

The present invention provides a cosmetic composition comprising vitamin C as an active ingredient, wherein vitamin C is dissolved in a solvent mixture of NMP and a multivalent alcohol. The cosmetic composition according to the present invention improves stability without causing skin irritation, thereby being useful as an antioxidant cosmetic composition. The composition of the present invention is in an anhydrous state and innovatively suppresses decomposition of vitamin C caused by problems which occur in hydrous state such as oxidation, etc., thereby effectively solving the problem of easily decomposing vitamin C caused by exposure to external environment such as water, temperature, light, etc.

Description

[0001] Stabilized non-epispastic vitamin C composition containing vitamin C [0002]

The present invention relates to a stabilized and skin irritation-reduced cosmetic composition containing vitamin C, and more particularly, to a composition for stabilizing vitamin C, which effectively inhibits oxidation of vitamin C by water as well as external environment such as temperature and light rays And which is free from skin irritation.

Vitamin C (ascorbic acid) enhances the immune function of the human body and promotes the production of collagen, which is a component of skin, cartilage, capillary blood vessels and muscles, and destroys chemical substances generated by penetration of ultraviolet rays into skin, . It also helps prevent wrinkles, maintain healthy skin, help to heal damaged skin tissues, prevent the formation of histamine, which is known to cause allergic reactions, and the formation of melamine, which fades skin during the aging process. Are known as antioxidants.

However, vitamin C has a structure similar to γ-lactone and is unstable and easily oxidized due to sensitivity to external environment such as water and air, especially oxygen, heat, and light. The oxidation of vitamin C produces dihydroaccocellular radicals, an intermediate of vitamin C due to the dissociation of hydrogen ions, which are usually two consecutive electron transfer processes, which are rich in reactivity It is known that it itself reacts with two molecules to produce one molecule of vitamin C and dihydroacercubic acid.

A very small amount is dissolved in a non-aqueous solution, whereas a large amount is dissolved in an aqueous solution. However, since a sufficient amount of vitamin C can not be stabilized due to rapid oxidation, a small amount of active ingredient Only vitamin C has been reported to be available.

A method of using an ascorbic acid derivative to complement the inherent problems of vitamin C and to improve its stability has been proposed, but it has a disadvantage in terms of efficiency.

Recently, as a method for preventing the oxidation of vitamin C, a method of using NMP (N-methyl-pyrrolidone) as a solvent has been proposed in order to stabilize anhydrous vitamin C in a formative aspect. (US Pat. No. 6,645,508 However, when NMP is used as a solvent, NMP is used as a solubilizer to stabilize vitamin C in anhydrous state. However, when NMP is used in an amount exceeding a proper amount, it is harmful to human and skin tissues, It showed no disadvantage.

Accordingly, the present inventors have conducted extensive research, and as a result, they have found that by using a solvent in which NMP and a polyhydric alcohol are mixed as a solvent, the solubility of vitamin C is sufficiently high enough to be used in cosmetics without skin irritation, It succeeded in solving it.

Accordingly, an object of the present invention is to provide a cosmetic composition which is effectively stabilized and free from skin irritation while containing vitamin C as an active ingredient.

According to an aspect of the present invention,

There is provided a cosmetic composition comprising vitamin C as an active ingredient in which vitamin C is dissolved in a mixed solvent of NMP and polyhydric alcohol.

The cosmetic composition according to the present invention as described above contains 15 to 40% by weight of vitamin, 30 to 43% by weight of NMP and 30 to 43% by weight of polyhydric alcohol based on the whole composition.

In the composition according to the present invention as described above, the polyhydric alcohol may be selected from the group consisting of ethylene glycol, propylene glycol, dipropylene glycol, diethylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, It is preferably one selected from the group consisting of glycerin, diglycerin, triglycerin, polyglycerin and polyethylene glycol, and particularly preferably the polyhydric alcohol may be propylene glycol.

As described above, the composition according to the present invention dissolves vitamin C in NMP and polyhydric alcohol to improve stability and eliminate skin irritation, and thus can be effectively used as an antioxidant cosmetic composition.

In addition, the composition according to the present invention is an innovative method for inhibiting the decomposition of vitamin C due to oxidation and other problems occurring in a water phase due to its non-aqueous phase, and is a vitamin C easily decomposed by external environment such as water, temperature, Which is a problem that has been solved effectively.

The composition according to the present invention is a cosmetic composition which is effective in stabilizing vitamin C by dissolving vitamin C in a mixed solvent of NMP and polyhydric alcohol, and having no skin irritation.

Hereinafter, the present invention will be described in detail with reference to examples. In the following examples, propylene glycol was used in the polyhydric alcohol, but similar results can be obtained even when any of the polyhydric alcohols described above is used.

&Lt; Preparation of composition according to the present invention >

The composition according to the present invention was prepared so as to have the content ratios shown in Table 1 below.

ingredient Content ratio (% by weight) Sample 1 Sample 2 Sample 3 Sample 4 Sample 5 Sample 6 Vitamin C 15 20 25 30 35 40 NMP 42.5 40 37.5 35 32.5 30 Propylene glycol 42.5 40 37.5 35 32.5 30

< Comparative example Composition Preparation>

The composition compositions of Comparative Examples were prepared so as to have the content ratios shown in Table 2 below.

ingredient Content ratio (% by weight) Comparative Sample 1 Comparative Sample 2 Comparative Sample 3 Vitamin C 20 30 40 NMP 80 70 60

<Safety Test of Composition: Skin Irritation Test>

1. Selection Criteria

* Adult men and women aged 20 to 55

* Those who understand the purpose and content of the test and express their intention to participate voluntarily

* A person who understands possible adverse reactions and signs written consent

* Applicants who can be trained during the test period

2. Criteria for excluding subjects

* If you have eczematous skin disease

* In case of infectious skin disease

* Allergic specificity

* Cosmetics, medicines, and daily irritation or allergy to daylight exposure

3. Selection of subjects

* We conducted physicochemical tests and questionnaires on dermatologists' skin for voluntary test subjects, and selected 30 individuals who met the criteria and did not qualify as exclusion criteria.

4. Skin patch exam( patch test ) Safety evaluation by human body application test

The subjects were visited 4 times (before the start of the test, on the day of removing the patch, after 24 hours, after 48 hours after the removal of the patch, and after 48 hours after the removal of the patch) during the period of application of the human body, and skin irritation was judged by the dermatologist.

At the first visit, subjects were tested for skin patches on their backs using IQ chambers (Chemotechnique Diagnostics, Sweden). The subjects were applied to the shoulder bones and waist line around the spine using an IQ chamber.

The test site was wiped with distilled water and dried. Then, 35 μl of the test sample prepared according to Table 1 and Table 2 was dropped into the IQ chamber, and then placed on the test site and fixed.

After 24 hours, the test area was marked with a marking pen. After 30 minutes, 24 hours and 48 hours, the test site was observed.

The skin response was classified according to the criteria of the International Association for Contact Dermatology (ICDRG) (see Table 3), the mean score was calculated according to the formula for the average skin response, The presence or absence of stimulation was determined.

sign score Criteria for Skin Response - 0 No stimulation ± 0.5 Missile: mild or slightly erythematous erythema + One Light Stimulation: Clear borders but weak erythema, edema and palsy ++ 2 Moderate irritation: marked erythema, papules and small follicles +++ 3 Stimulation of the river: severe swelling and alveoli, scab formation

Grade mean score Unstimulated (1) 0.00 to 0.75 Unstable (2) 0.76 to 1.50 Light stimulus (3) 1.51 to 2.50 Medium Stimulus (4) 2.51 to 4.00 Stimulants stimulating (5) 4.01 ~

5. Test Results

As shown in the following Table 5, the samples 1 to 6 according to the present invention were judged to be non-stimulated because they could not observe the reaction at 30 minutes, 24 hours and 48 hours after the removal of the patch, Minute, 24 hours, and 48 hours after the onset of symptoms.

Name of sample
Number of reactants
Reactivity Average skin response 30 minutes 24 hours 48 hours Sample 1 0 0 0 0 0 Sample 2 0 0 0 0 0 Sample 3 0 0 0 0 0 Sample 4 0 0 0 0 0 Sample 5 0 0 0 0 0 Sample 6 0 0 0 0 0 Comparative Sample 1 21 3.08 2.89 2.57 2.85 Comparative Sample 2 24 3.24 3.04 2.79 3.02 Comparative Sample 3 28 3.57 3.26 2.99 3.27

According to the present test results, the cosmetic composition according to the present invention is a non-stimulated cosmetic composition having no skin irritation when compared with a conventional vitamin C cosmetic composition.

&Lt; Stability test of composition: Vitamin C Potency Measurement>

In order to examine the potency of vitamin C to maintain the potency of the composition prepared according to Tables 1 and 2, the initial potency of vitamin C was 100, and the potency of vitamin C after 1 month was measured at 25 ° C and 45 ° C, The results are shown in Table 6 below.

The measurement was performed using a Waters SunFire C18 5,100 A, 150 X 4.6 mm column. At this time, the wavelength of the detector was set to 254 nm, and the mobile phase was measured with a flow rate of 0.6 mL / min using 25 mM KH ₂ PO ₄ buffer (pH 2.5).

Remarks Sample 1 Sample 2 Sample 3 Sample 4 Sample 5 Sample 6 compare
Sample 1 compare
Sample 2 compare
Sample 3 25 ℃ 99 98 99 99 98 97 99 99 97 45 ° C 90 91 91 92 90 89 91 91 89

As can be seen from Table 6, it was confirmed that the reversibility of vitamin C was sufficiently maintained in both the cosmetic composition according to the present invention and the cosmetic composition according to the prior art. Therefore, it can be confirmed that the composition according to the present invention has stability that is not inferior to the composition of the prior art.

&Lt; Stability test of composition: Discoloration, Fling >

The composition prepared according to Tables 1 and 2 was stored in an opaque glass container in a thermostatic chamber kept constant at 45 DEG C for 12 weeks in order to examine the stability of the formulation and was kept in a completely shaded refrigerator After storage for 12 weeks in an opaque glass container, discoloration and degree of discoloration were measured. The results are shown in Table 7 below.

At this time, the degree of product discoloration and degree of detachment was classified into the following six grades and evaluated.

0: No change 1: Extremely small

2: a little bit 3: a bit badly

4: Severely 5: Extremely severe

discoloration Fling
Sample 1 45 ° C 0.1 0.1 4 ℃ 0 0
Sample 2 45 ° C 0.1 0.1 4 ℃ 0 0
Sample 3 45 ° C 0.1 0.15 4 ℃ 0 0
Sample 4 45 ° C 0.15 0.1 4 ℃ 0 0
Sample 5 45 ° C 0.15 0.15 4 ℃ 0 0
Sample 6 45 ° C 0.15 0.15 4 ℃ 0 0
Comparative Sample 1 45 ° C 0.1 0.1 4 ℃ 0 0
Comparative Sample 2 45 ° C 0.15 0.15 4 ℃ 0 0
Comparative Sample 3 45 ° C 0.15 0.15 4 ℃ 0 0

As shown in Table 5, it was found that there was almost no color change or peeling at 45 DEG C in the cosmetic composition according to the present invention and the prior art. Therefore, it was found that the composition according to the present invention had a formulation stability comparable to that of the conventional cosmetic composition.

As described above, it can be seen that the composition according to the present invention is a composition which can sufficiently dissolve vitamin C up to 15 to 40% by weight, but also has excellent safety and chemical stability without skin irritation at all.

Claims

The active ingredient is prepared by dissolving vitamin C in a mixed solvent of NMP and polyhydric alcohol so as to contain 15 to 40% by weight of vitamins, 30 to 43% by weight of NMP and 30 to 43% by weight of polyhydric alcohol, And is free from skin irritation.

delete

The polyhydric alcohol according to claim 1, wherein the polyhydric alcohol is at least one selected from the group consisting of ethylene glycol, propylene glycol, dipropylene glycol, diethylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, butoxydiglycol, glycerin, diglycerin, Glycerin, polyglycerin, and polyethylene glycol. The cosmetic composition of claim 1, wherein the cosmetic composition is a cosmetically acceptable composition.

4. The cosmetic composition according to claim 3, wherein the polyhydric alcohol is propylene glycol.