KR101514014B1 - Multi-part tooth bleaching composition and method of bleaching tooth - Google Patents

Abstract

A multi-part tooth whitening composition and a tooth whitening method are disclosed. The disclosed multi-part tooth whitening composition comprises a whitening gel composition and an activation liquid composition, wherein the whitening gel composition comprises a dental whitening agent, a binder and a first solvent, wherein the activation liquid composition comprises A metal component and a second solvent.

Description

[0001] The present invention relates to a multi-part tooth whitening composition and a method of bleaching tooth,

A tooth whitening composition and a tooth whitening method are disclosed. More particularly, a multi-part tooth whitening composition and a tooth whitening method comprising a whitening gel composition and an activation liquid composition are disclosed.

From ancient times to the present, the desire for beauty has been the primary wind of all people. As society has developed and the economic activities of modern people have increased, the frequency of contact with people has increased and the aesthetic expectation for teeth has increased. to be. Therefore, people want to keep their teeth clean and white.

There are several factors that affect the esthetics of the teeth such as the arrangement, size, color, texture, and light transmission of the teeth. Among them, the color of the teeth is the most sensitive and important factor. It can also cause psychological problems.

Tooth discoloration can be divided into endogenous discoloration and extrinsic discoloration. Endogenous discoloration has genetic discoloration, discoloration due to drug or trauma, and extrinsic discoloration has chemical discoloration and discoloration due to aging.

Tooth whitening refers to a treatment process that uses the pharmacological action of a whitening ingredient to restore the enamel pigmented or discolored by the pigment to its original hue.

The main substance that shows tooth whitening effect is hydrogen peroxide (H ₂ O ₂ ), which is an important ingredient that removes organic substances attached to the teeth by oxidation and bleaches the discolored areas.

Teeth whitening can be broadly classified into dental clinics using high-density whitening agents (for example, hydrogen peroxide), office bleaching, and home bleaching using low-density whitening agents at home. . The professional tooth whitening has an advantage that a large effect can be obtained within a short time, but there is a safety problem that can cause a gingival injury or a tooth whitening by carelessness during a procedure. On the other hand, the above-mentioned self-whitening is safe, but it takes a considerable time to see the whitening effect.

Recently, various side effects such as hyperhidrosis associated with the use of high concentration of hydrogen peroxide have been reported. Therefore, the development of whitening agent is focused on safety as well as efficacy. Accordingly, various types of self-whitening agents that can be safely and conveniently used by ordinary people in daily life have been developed by using hydrogen peroxide at a low concentration.

However, although self-whitening using a low concentration of hydrogen peroxide is safe, it is difficult to see the whitening effect in a short period of time. In order to obtain the whitening effect, not only is it inconvenient to use it many times over a long period of time, It is general that it does not reach the effect.

Therefore, it is necessary to develop a tooth whitening agent that can improve the aesthetic satisfaction of patients by improving the effect of oxidizing action of hydrogen peroxide while ensuring human safety by using low concentration hydrogen peroxide.

One embodiment of the present invention provides a multi-part tooth whitening composition comprising a whitening gel composition and an activation liquid composition.

Another embodiment of the present invention provides a tooth whitening method using the multi-part tooth whitening composition.

According to an aspect of the present invention,

A whitening gel composition; And

An active liquid composition,

Wherein the whitening gel composition comprises a dental whitening agent, a binder and a first solvent,

The activation liquid composition provides a multi-part tooth whitening composition comprising a metal component that promotes decomposition of the dental whitening agent and a second solvent.

The dental whitening agent may include peroxides, hypochlorites, percarbonates, peroxides or combinations thereof.

The binder may comprise a polymer.

The polymer may have a weight average molecular weight of 500,000 to 4,000,000.

The first solvent may comprise water, ethanol or a combination thereof.

The whitening gel composition may include 100 parts by weight of the dentifrice whitening agent, 30 to 1,700 parts by weight of the binder, and 300 to 3,200 parts by weight of the first solvent.

The metal component of the activated liquid composition may be derived from a metal salt.

The metal salt may include an iron salt, a calcium salt, a magnesium salt, a copper salt, or a combination thereof.

The activated liquid composition may further comprise a chelating agent.

The activation liquid composition may have a metal ion concentration of 0.05 to 1 mM.

The content of the activation liquid composition may be 5 to 100 parts by weight based on 100 parts by weight of the whitening gel composition.

The multi-part tooth whitening composition may further comprise 50 to 150 parts by weight of an activated gel composition per 100 parts by weight of the whitening gel composition, and the activated gel composition may include a pH adjusting agent, an additional binder and a third solvent.

The pH adjusting agent may comprise sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, tris (hydroxymethyl) aminomethane, triethanolamine or combinations thereof.

The activated gel composition may include 100 parts by weight of the pH adjusting agent, 4 to 350 parts by weight of the additional binder, and 500 to 950 parts by weight of the third solvent.

The content of the dental whitening agent may be 3 to 35 parts by weight based on 100 parts by weight of the whitening gel composition and the activated gel composition.

According to another aspect of the present invention,

And applying the multi-part tooth whitening composition to a tooth surface.

The tooth whitening method comprises: applying the activation liquid composition to the tooth surface to obtain a primary treatment surface; and applying the whitening gel composition or a mixture of the whitening gel composition and the activated gel composition to the primary treatment surface .

Although the multi-part tooth whitening composition according to an embodiment of the present invention includes a low-concentration whitening agent, an effective whitening effect can be obtained even with a small number of times of use within a short time as compared with the existing whitening composition.

1 is a photograph showing a whitening effect of a multi-part tooth whitening composition according to an embodiment of the present invention.
2 is a photograph showing the degree of oral mucosal irritation of a multi-part tooth whitening composition according to an embodiment of the present invention.

Hereinafter, the multi-part tooth whitening composition according to one embodiment of the present invention will be described in detail.

A multi-part tooth bleaching composition according to one embodiment of the present invention comprises a whitening gel composition and an activation liquid composition. As used herein, " multi-part tooth whitening composition " means a tooth whitening composition comprising two or more compositions physically separated from each other.

The whitening gel composition comprises a dental whitening agent, a binder and a first solvent.

The activation liquid composition comprises a metal component and a second solvent that promote decomposition of the dental whitening agent.

The whitening gel composition and the activating liquid composition are physically separated from each other to maintain the chemical stability of the dental whitening agent before being used for tooth whitening. When used for tooth whitening, the whitening gel composition and the activating liquid composition are sequentially applied to the surfaces of the teeth, Thereby accelerating the decomposition reaction (i.e., oxidation reaction or ionization reaction) of the dental whitening agent, thereby maximizing the whitening effect.

The dental whitening agent decomposes and reacts with a coloring component (for example, protein) present on the surface of the tooth to remove the coloring component.

The dental whitening agent may include peroxides, hypochlorites, percarbonates, peroxides or combinations thereof.

The peroxide may include hydrogen peroxide, sodium peroxide, potassium peroxide, carbamide peroxide, sodium perborate, sodium percarbonate, or a combination thereof.

The hypochlorite may include sodium hypochlorite, potassium hypochlorite, calcium hypochlorite, barium hypochlorite, or combinations thereof.

The percarbonate may include sodium percarbonate, potassium percarbonate, or a combination thereof.

The peroxide may include peroxyacetic acid, peroxyphosphoric acid, peroxodisophosphoric acid, peroxic sulfuric acid, peroxic di-sulfuric acid, peroxic acid, or a combination thereof.

The binder serves to bind the components of the whitening gel composition.

The binder may comprise a polymer. The polymer may have a weight average molecular weight of 500,000 to 4,000,000. For example, the binder may comprise an ionic polymer, a nonionic polymer, or a combination thereof.

The ionic polymer may include carboxymethyl cellulose, carboxypropyl cellulose, or a combination thereof.

The nonionic polymer may be at least one selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, hydroxyethyl cellulose, hydroxypropyl cellulose, polyacrylic acid, . ≪ / RTI >

The first solvent serves to dissolve the dental whitening agent and the binder. Such a first solvent may comprise water, ethanol or a combination thereof.

The whitening gel composition may include 100 parts by weight of the dentifrice whitening agent, 30 to 1,700 parts by weight of the binder, and 300 to 3,200 parts by weight of the first solvent.

If the content of the binder and the first solvent is within the above ranges for each 100 parts by weight of the dentifrice whitening agent, the whitening gel composition is suitable for viscosity so that the whitening gel composition is not easily diluted or lost by the saliva, , And can have excellent phase stability.

The whitening gel composition may further comprise other additives such as fragrances, antihypertensive agents, dental caries inhibitors, gum disease improvement agents or combinations thereof.

The fragrance may include peppermint, spearmint, citrus, herb, menthol, or a combination thereof.

The hypersensitive agent may be potassium nitrate, stannous fluoride, sodium monofluorophosphate (MFP), sodium fluoride (NaF), sodium fluoride (Na ₂ SiF ₆ : sodium silicofluoride) or a combination thereof.

The dental caries inhibitor may comprise sodium fluoride (NaF), calcium fluoride (CaF ₂ ) or a combination thereof.

The gum disease-improving agent may be selected from bamboo salt, tocopherol acetate, vitamin D, alantoin chlorohydroxy aluminum, triclosan, xylitol, calcium glycerophosphate, aminocaproic acid, KNO ₃ , sodium monofluoro Sodium monofluorophosphate, an enzyme, or a combination thereof.

The content of the other additives can be appropriately adjusted within a range that can improve the feel and functionality of the whitening gel composition without causing any significant change in the shape and stability of the whitening gel composition.

The activated liquid composition has affinity for components of the enamel (e.g., an inorganic component), so that it easily migrates toward the enamel when applied to a tooth surface. In addition, the activated liquid composition applied to the enamel serves to help the whitening gel composition easily migrate toward the enamel. Accordingly, the metal component (particularly, the metal ion) in the activated liquid composition can decompose the dental whitening agent applied to the tooth surface, thereby effectively removing coloring components deep in enamel, thereby increasing the tooth whitening effect. As such, the metal component in the activated liquid preparation composition accelerates the decomposition of the dental whitening agent to activate tooth whitening, and even if a dental whitening agent having a low concentration (about 3 wt% of the total weight of the whitening gel composition and the activated gel composition) is used It plays a role of enabling quick and effective tooth whitening.

The metal component included in the activated liquid composition may be one derived from a metal salt. Such a metal component may be a metal ion, a center metal forming a chelate compound, or a combination thereof.

The metal salt may include an iron salt, a calcium salt, a magnesium salt, a copper salt, or a combination thereof. However, the present invention is not limited thereto, and the metal salt may include other transition metal salts and / or other alkali metal salts.

The iron salt may be selected from the group consisting of iron (II) chloride, iron (III) chloride, iron bromide, iron sulfate, iron nitrate, iron (II) acetate, iron propionate, iron citrate, iron gluconate, iron lactate, iron oxide, And at least one compound selected from the group consisting of ferric salts and ferrous salts.

Wherein the calcium salt is selected from the group consisting of hydrated calcium chloride (CaCl ₂ xH ₂ O, x = 1, 2, 4 or 6), anhydrous calcium chloride (CaCl ₂ ), calcium glycerophosphate, calcium fluoride (CaF ₂ ), calcium citrate, calcium gluconate , Calcium oxide, calcium ascorbinate, calcium lactate, calcium primary phosphate, calcium secondary phosphate, calcium tertiary phosphate, calcium carbonate, calcium pantothenate, or combinations thereof.

The magnesium salt may include magnesium phosphate, magnesium nitrate, magnesium acetate, magnesium chloride, magnesium carbonate, magnesium sulfate, magnesium gluconate, magnesium hydroxide or a combination thereof.

The copper salt includes copper pyrophosphate, copper sulfate, copper nitrate, copper (II) acetate, copper (I) chloride, copper (II) chloride, copper carbonate (CuCO ₃ ), copper gluconate, copper hydroxide or a combination thereof can do.

The second solvent may be the same as or similar to the first solvent.

The activated liquid composition may further comprise a chelating agent. The chelating agent is intended to prevent the reduction of the metal ion contained in the activation liquid composition (for example, the reaction of the metal ion and the hydroxyl group present on the tooth surface) and the precipitation of the metal. That is, the chelating agent forms a chemically stable chelate compound to be added to the metal ion.

The chelating agent may include EDTA (ethylenediaminetetraacetic acid), sodium citrate, bisphosphonate, EGTA (ethylene glycol tetraacetic acid), ethylenediamine, oxine, orthophenanthroline or a combination thereof.

The activation liquid composition may further include the other additives.

The activation liquid composition may have a metal ion concentration of 0.05 to 1 mM. If the activated liquid composition comprises a chelate compound, the center metal of the chelate compound is also included in the calculation of the concentration of the metal ion. If the metal ion concentration is within the above range, an excellent tooth whitening effect can be obtained without causing additional coloration caused by excessive metal ions.

The content of the activation liquid composition may be 5 to 100 parts by weight based on 100 parts by weight of the whitening gel composition. If the content of the activating liquid composition is within the above range with respect to 100 parts by weight of the whitening gel composition, an excellent tooth whitening effect can be obtained without additional coloration caused by the presence of excessive metal ions.

The multi-part tooth whitening composition may further comprise an activated gel composition.

The active gel composition is physically separated from the whitening gel composition to maintain the chemical stability of the dentifrice before it is used for tooth whitening, and when used for whitening the whitening gel composition, the active whitening gel composition is mixed with the whitening gel composition, Thereby further maximizing the whitening effect. In addition, the activated gel composition is also physically separated from the activated liquid composition prior to its use in tooth whitening. For example, the activated liquid composition is filled in a single syringe and the whitening gel composition and the activated gel composition are applied to two tubes of a dual syringe equipped with a mixing tip It can be used for tooth whitening after being separately charged.

Specifically, the activated gel composition is mixed with the whitening gel composition at the time of tooth whitening, and further applied to the tooth surface to which the activation liquid composition has already been applied to maximize the decomposition of the dental whitening agent on the tooth surface, And enables effective tooth whitening.

The activated gel composition may comprise a pH adjusting agent, an additional binder and a third solvent.

The pH adjusting agent promotes the decomposition of the dental whitening agent. Such pH adjusting agents may include sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, tris (hydroxymethyl) aminomethane, triethanolamine or combinations thereof.

The additional binder may be the same as or similar to the binder.

The third solvent may be the same as or similar to the first solvent.

The activated gel composition may include 100 parts by weight of the pH adjusting agent, 4 to 350 parts by weight of the additional binder, and 500 to 950 parts by weight of the third solvent.

If the content of the additional binder and the third solvent is within the above range with respect to 100 parts by weight of the pH adjusting agent, the viscosity of the activated gel composition is appropriate so that the activated gel composition is not easily diluted or lost by the saliva, Can be easily applied, and can have excellent phase stability.

The content of the activated gel composition may be 50 to 150 parts by weight based on 100 parts by weight of the whitening gel composition. When the content of the activated gel composition is within the above range with respect to 100 parts by weight of the whitening gel composition, the pH of the mixture of the whitening gel composition and the activated gel composition becomes appropriate, and thus the human safety is excellent. .

The content of the dental whitening agent may be 3 to 35 parts by weight based on 100 parts by weight of the whitening gel composition and the activated gel composition. If the content of the dental whitening agent is within the above range with respect to the total weight of 100 parts by weight of the whitening gel composition and the activated gel composition, a superior tooth whitening effect can be obtained without fear of the occurrence of tooth whitening and gingival damage.

Another embodiment of the present invention provides a tooth whitening method comprising applying the multi-part tooth whitening composition to a tooth surface.

The tooth whitening method comprises the steps of applying the activating liquid composition to the teeth surface to obtain a primary treatment surface and applying the whitening gel composition or a mixture of the whitening gel composition and the activated gel composition to the primary treatment surface Step < / RTI >

When the activated liquid composition is applied to the teeth surface, the activated liquid composition may be filled in a single syringe and then released into a brush to be applied.

When the above-mentioned whitening gel composition alone is applied to the primary treatment surface, the whitening gel composition may be filled in a single syringe and then discharged onto a brush to be applied.

Alternatively, when the mixture of the whitening gel composition and the activated gel composition is applied to the primary treatment surface, the whitening gel composition is charged into one tube of a dual syringe equipped with a mixing tip, After charging the other tube of the dual syringe, the two compositions may be mixed by pressing the plunger, and then the mixture may be applied to the brush to be applied.

Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited to these embodiments.

Example

Example  Preparation of 1: 2 Partial Tooth Whitening Composition

(Preparation of a whitening gel composition)

100 parts by weight of hydrogen peroxide, 83.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 1,483 parts by weight of purified water were mixed to prepare a whitening gel composition.

(Preparation of Activator Solution Composition)

Iron chloride (II) was dissolved in purified water to prepare an activation liquid composition having an iron ion concentration of 0.2 mM.

(Preparation of two-part tooth whitening composition)

100 parts by weight of the above whitening gel composition was filled in a single syringe (3 mL of a syringe), and 50 parts by weight of the activated liquid composition was filled in another single syringe (Norm-Ject, syringe 2 mL) to prepare a two-part tooth whitening composition .

Example  Preparation of 2: 3 Partial Teeth Whitening Composition

(Preparation of a whitening gel composition)

100 parts by weight of hydrogen peroxide, 83.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 1,483.6 parts by weight of purified water were mixed to prepare a whitening gel composition.

(Preparation of activated gel composition)

100 parts by weight of sodium carbonate, 33.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 533.3 parts by weight of purified water were mixed to prepare an activated gel composition.

(Preparation of Activator Solution Composition)

Iron chloride (II) was dissolved in purified water to prepare an activation liquid composition having an iron ion concentration of 0.1 mM.

(Preparation of three-part tooth whitening composition)

100 parts by weight of the whitening gel composition was charged into one tube of a dual syringe (Sulazer, Double Syringe, 1: 1) equipped with a mixing tip, 100 parts by weight of the activated gel composition was charged into the other tube of the dual syringe, 50 parts by weight of the activated liquid composition was filled in a single syringe (Norm-Ject, syringe 2 mL) to prepare a three-part tooth whitening composition. The content of hydrogen peroxide in the three-part tooth whitening composition thus prepared was 3 parts by weight based on 100 parts by weight of the total weight of the whitening gel composition and the activated gel composition.

Evaluation example

Evaluation example  1: Evaluation of whitening effect

The three-part tooth whitening composition prepared in Example 2 was applied to four human teeth having similar shade steps, and each whitened tooth was visually observed to evaluate the whitening effect according to the VITA Shade Classical Guide. Specifically, the application of the three-part tooth whitening composition was carried out as follows: (i) The activation liquid composition was applied to each of the teeth with a brush. (ii) A mixture of the whitening gel composition and the activated gel composition was applied to each of the teeth with a brush and left for 10 minutes. The above (i) and (ii) were repeated three more times. The photographs of the teeth before the whitening treatment and the teeth after the whitening treatment were photographed and shown in Fig. In Fig. 1 (a), the rows are the teeth before the whitening treatment, and (b) the teeth are the teeth after the whitening treatment.

Referring to FIG. 1, even though a whitening composition containing hydrogen peroxide in a low concentration (that is, 3 parts by weight with respect to 100 parts by weight of the total weight of the whitening gel composition and the activated gel composition) was subjected to whitening treatment for a short time within 60 minutes, It was found that the shade stage of the whitened teeth was improved by one to two stages compared to the teeth before the whitening treatment.

Evaluation example  2: Oral mucosal irritation evaluation

To indirectly evaluate the human stability (i.e., gingival irritation and toxicity) of the three-part tooth whitening composition prepared in Example 2, four hamsters were subjected to a hamster ball pocket oral cavity according to KS P ISO 10993-10: 2007 Mucosal irritation test was conducted, and the results are shown in Fig. Four tooth whitening compositions and the same coating method were used for the four hamsters. In FIG. 2, a ball pocket located on the left side of the drawing among the two ball bags of each hamster is a tooth whitening composition untreated group, and a ball pocket located on the right side of the drawing is a tooth whitening composition treatment group.

2, remarkable whitening and irritation such as erythema were not observed in the four hamsters.

From the results of Evaluation Examples 1 and 2, it can be confirmed that the three-part tooth whitening composition prepared in Example 2 improves the tooth whitening effect and also has excellent human stability.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

Claims (17)

A whitening gel composition; And
An active liquid composition,
Wherein the whitening gel composition comprises a dental whitening agent, a binder and a first solvent,
Wherein the activation liquid composition comprises a metal component and a second solvent that promote decomposition of the dental whitening agent,
The whitening gel composition and the activated liquid composition are physically separated from each other before being used for tooth whitening, and when used for tooth whitening, the active liquid composition is first applied to the surface of teeth and the whitening gel composition is applied later A tooth whitening composition. The method according to claim 1,
Wherein the dental whitening agent comprises peroxide, hypochlorite, percarbonate, peroxide, or a combination thereof. The method according to claim 1,
Wherein the binder comprises a polymer. The method of claim 3,
Wherein the polymer has a weight average molecular weight of 500,000 to 4,000,000. The method according to claim 1,
Wherein the first solvent comprises water, ethanol or a combination thereof. The method according to claim 1,
Wherein the whitening gel composition comprises 100 parts by weight of the dentifrice whitening agent, 30 to 1,700 parts by weight of the binder, and 300 to 3,200 parts by weight of the first solvent. The method according to claim 1,
Wherein the metal component of the activated liquid composition is derived from a metal salt. 8. The method of claim 7,
Wherein the metal salt comprises an iron salt, a calcium salt, a magnesium salt, a copper salt, or a combination thereof. The method according to claim 1,
Wherein the activation liquid composition further comprises a chelating agent. The method according to claim 1,
Wherein the activated liquid composition comprises a metal ion concentration of 0.05 to 1 mM. The method according to claim 1,
Wherein the amount of the activating liquid composition is 5 to 100 parts by weight per 100 parts by weight of the whitening gel composition. The method according to claim 1,
Wherein the multi-part tooth whitening composition further comprises 50-150 parts by weight of an activated gel composition for 100 parts by weight of the whitening gel composition, wherein the activated gel composition comprises a pH adjusting agent, an additional binder and a third solvent . 13. The method of claim 12,
Wherein the pH adjusting agent comprises sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, tris (hydroxymethyl) aminomethane, triethanolamine or a combination thereof. 13. The method of claim 12,
Wherein the activated gel composition comprises 100 parts by weight of the pH adjusting agent, 4 to 350 parts by weight of the additional binder, and 500 to 950 parts by weight of the third solvent. 13. The method of claim 12,
Wherein the content of the dental whitening agent is 3 to 35 parts by weight based on 100 parts by weight of the whitening gel composition and the activated gel composition. A tooth whitening method comprising applying a multi-part tooth whitening composition according to any one of claims 1 to 15 to a tooth surface,
Applying the activation liquid composition to the tooth surface to obtain a primary treatment surface; And
Applying the whitening gel composition, or a mixture of the whitening gel composition and the activated gel composition, to the primary treatment surface,
The activated liquid composition has affinity for enamel when applied to a tooth surface so that it can easily migrate toward the enamel and the activated liquid composition applied to the enamel serves to facilitate the movement of the whitening gel composition toward the enamel A tooth whitening method. delete

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