KR101494825B1 - Soft capsule having starch as main ingredient and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a method for manufacturing a soft capsule having starch as a main ingredient and to a soft capsule having starch as a main ingredient that is manufactured thereby, the manufacturing method comprising the steps of: generating mixed raw materials by mixing 50 to 70 wt% of soluble starch, 20 to 30 wt% of a viscosity adjuster and 1 to 20 wt% of a humidity adjuster together with 1-10 wt% of water; generating a raw capsule from the mixed raw materials via a seamless capsule manufacturing machine; curing the surface of the raw capsule by using a curing agent; and finishing the soft capsule by coating the cured raw capsule with coating liquid.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a soft capsule containing starch as a main component,

The present invention relates to a soft capsule containing starch as a main component and improving its price competitiveness by using starch which is inexpensive and a method for producing the same.

Soft capsules are increasingly being used in medicine, cosmetics, health foods, and the like.

The present technology can be divided into the technology of enjoying the sound and feeling when it bursts and the technique of commercializing it so as not to be broken easily by using the strength to break up and break. As a main component of such a soft capsule, carrageenan or gelatine has been used as a main preparation (more than 50% of it has been used), and plasticizers, alginates, saccharides and dextrins have been used as adjuvants.

When carrageenan or gelatin is used as the main material for gelation, the cost of these ingredients is high, which increases the cost, and when gelatin is used, it is an animal-derived material.
[Prior Art]
Patent No. 10-2010-0047349 (2010.05.07)

The present invention provides a soft capsule containing starch as a main component and a starch-containing starch as a main ingredient, less influenced by humidity, and excellent in blistering property, and a process for producing the same.

In order to solve the above problems, there is provided a method for producing a soft capsule comprising starch as a main component, which is one embodiment of the present invention, which comprises the steps of: preparing 50 to 70 wt.% Of soluble starch; 20 to 30 wt.% Of a viscosifying agent; Producing a mixed raw material to be mixed with water; Generating an original capsule through a seamless capsule maker; Curing the surface of the aid capsule using a curing agent; And coating the hardened original capsule with a coating liquid to complete the soft capsule.

At least one of carrageenan and gelatin may be used as the viscosifying agent.

Here, alginates may be used as the humidity control agent.

Here, the content of the alginate in the components of the soft capsule may be 20 wt% or less of the soluble starch.

Here, one of calcium chloride and calcium lactate may be used as the curing agent.

The step of mixing the soluble starch with 50 to 70% by weight of the starch, 20 to 30% by weight of the viscosifying agent and 1 to 20% by weight of the moisture control agent together with water may be performed by mixing 1 to 10% And producing the mixed raw material.

Here, glycerin may be used as the plasticizer.

At least one of waxes, waxes, hydrogenated oil and HPMC (Hydroxy Propyl Methyl Cellosse) may be used as the coating solution.

Another embodiment of the present invention is a soft capsule comprising a starch as a main component, comprising a first component consisting of 50 to 70% by weight of soluble starch; A second component consisting of 20 to 30% by weight of a mixture of carrageenan, gelatin or a mixture of carrageenan and gelatin; A third component composed of 1 to 20% by weight of alginate; And 1 to 10% by weight of glycerin.

Here, the soft capsule may include a gel layer formed by gelation treatment using at least one of calcium chloride and calcium lactate on the surface of the soft capsule.

Here, the coating layer may be formed on the gel layer.

Here, the coverage rate of the soft capsule may be 5 to 20%.

Here, the diameter of the soft capsule may be 0.25 to 10 mm.

Here, the thickness of the soft capsule may be less than 60 mu m.

According to one embodiment of the present invention having the above-described structure, it is possible to provide a soft capsule containing starch as a main component, which is low in cost and excellent in storability, and has high cost, such as gelatin or carrageenan, Can be provided.

According to one embodiment of the present invention, since it is not necessary to use a pH neutralizing agent or the like, the manufacturing process can be simplified.

1 is a flow chart for explaining a method of manufacturing a soft capsule containing starch as a main component according to an embodiment of the present invention.
2 is a cross-sectional view for explaining the structure of a soft capsule containing starch as a main component, which is an embodiment of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings. In the present specification, the same or similar reference numerals are given to different embodiments in the same or similar configurations.

FIG. 1 is a flowchart for explaining a method of manufacturing a soft capsule having starch as a main component, which is an embodiment of the present invention. As shown in FIG. 1, a method of manufacturing a soft capsule containing starch as a main component, which is an embodiment of the present invention, comprises first mixing soluble starch, a viscosifying agent, a humidity control agent, and a plasticizer in water to produce a mixed raw material (S1). Here, the soluble starch is contained in an amount of 50 to 70% by weight, the viscosifying agent in an amount of 20 to 30% by weight, the humidity control agent in an amount of 1 to 20% by weight, and the plasticizer in an amount of 1 to 10% by weight.

The soluble starch has the advantage that it can be prepared without using a PH modifier. In general, starch has disadvantages in the hygroscopicity of starch and deterioration of the spreading effect, but soluble starch can somewhat compensate for such disadvantages.

In particular, the soluble starch has low adhesion and the capsule strength is not greatly influenced by the content of soluble starch, and has a high drying speed and a low calorie consumption during drying.

Such soluble starch is contained in an amount of 50 to 70% by weight. When the soluble starch is 50 wt% or less, it is difficult to obtain sufficient economical efficiency, and starch can not be regarded as a main component. On the other hand, when it is 70% by weight or more, the viscosity is weak and it is difficult to manufacture the aid capsule.

As viscosity modifiers, carrageenan or gelatin may be used. When the viscosity control agent, such as carrageenan or gelatin, is used, the thickening effect is enhanced so that the original capsule can be produced with a superior quality at the time of manufacturing the original capsule through the seamless capsule. It is difficult to produce the aid capsules. In consideration of other essential ingredients, less than 30% by weight is included. The viscosity is adjusted to 30 to 150 mPa · s, more preferably to 50 to 100 mPa · s using such a viscosity modifier.

As the humidity controller, alginate salts are used, and the humidity control agent is contained in an amount of 20 wt% or less of the soluble starch. This alginate as a humidity control agent reacts with a curing agent to gel the soft capsule. Accordingly, the moisture resistance can be improved.

The plasticizer may be contained in an amount of 1 to 10% by weight. The plasticizer is used for improving moldability. Examples of such a plasticizer include polyhydric alcohols such as glycerin, polyethylene glycol, propylene glycol and polypropylene glycol, and examples thereof include monosaccharides such as glucose, fructose, glucose and galactose, disaccharides such as sucrose, maltose and tallocarose, oligosaccharides such as glucose, Polysaccharides such as gum arabic, galactan and borax, sugar alcohols such as sorbitol, maltitol, lactitol, talatinite, xylitol, mannitol and galactitol, and the like can be used.

As described above, the raw material containing the soluble starch, the viscosifying agent, the humidity control agent and the water is prepared in the seamless capsule manufacturing machine (S3). The aid capsules can be prepared by a dropping method. The dropping method is a method of making a seamless capsule by discharging the mixed raw materials from the outer nozzle and the contents (fragrance, drug, etc.) from the inner nozzle simultaneously using the concentric double nozzle. The aid capsules may be prepared by liquid-phase hardening or orifice method.

The surface of the aid capsule is cured through a curing agent (S5). Such a curing agent may be used including one of calcium chloride and calcium lactate. That is, the aid capsules may be cured with an aqueous solution of calcium chloride or calcium lactate. In other words, the curing agent obtained by immersing the aid capsule produced in the step S3 in the aqueous solution and curing the surface of the aid capsule undergoes a chemical reaction with the alginate as a calcium ion preparation as a calcium ion preparation, thereby curing the surface.

Such a curing treatment method includes: 1) a method of immersing the capsule in an aqueous solution of the curing agent in the state that the capsule contains the moisture before drying, and 2) a method of immersing the dried capsule in an aqueous solution of the curing agent after formation of the original capsule. The aqueous solution of calcium chloride, which is an aqueous solution of the hardening agent, is suitable because the curing speed is increased and the soluble starch and the like are not decomposed when the concentration is 10 to 30%.

Then, after drying it, the surface is coated using a coating solution (S7). As this coating liquid, waxes, waxes, hydrogenated oil, HPMC (Hydroxy Propyl Methyl Cellosse) and the like can be used. The coating layer is formed by the coating liquid and the moisture resistance is improved. When the curing agent aqueous solution contains ethanol and is used as a curing agent for the aid capsule, the curing rate can be increased.

Examples of the coating method include a method in which a coating agent is dissolved in a solvent to volatilize the solvent after the dispersion is sprayed (a method using a coating pan), a method in which a capsule is immersed in a coating solvent dissolved by dissolving the coating agent in a solvent, (Dumping method), and a method in which a suspension is dispersed in advance in the production of capsule shell (combined method).

When a coating agent is introduced into the capsule shell, a suitable emulsifier can be used.

Accordingly, a soft capsule containing starch as a main component, which is an embodiment of the present invention, comprises a first component composed of 50 to 70% by weight of soluble starch; A second component consisting of 20 to 30% by weight of a mixture of carrageenan, gelatin or a mixture of carrageenan and gelatin; A third component composed of 1 to 20% by weight of alginate; And 1 to 10% by weight of glycerin.

Here, a gel layer formed by gelation treatment (curing treatment) using at least one of calcium chloride and calcium lactate on the surface of the soft capsule may be included.

Then, the soft capsule is dried (S9).

The structure of the soft capsule manufactured according to one embodiment of the present invention having the above-described structure will be described in detail with reference to FIG.

FIG. 2 is a cross-sectional view illustrating a structure of a soft capsule having starch as a main component according to an embodiment of the present invention. As shown in FIG. 2, a soft capsule containing starch as a main component according to the present invention mainly comprises a capsule 100 and contents C accommodated therein.

Here, the film 100 is produced by the method described in Fig. 1, and as the content (C), flavor such as avocado oil, fennel oil and the like can be used as oils and fats. Various kinds of seed oil, various kinds of grain oil, fish oil, egg yolk oil, various kinds of vegetable oil, various kinds of fatty acid oil, and the hydrogenation of resin are also applicable.

The content may include fatty acids. As fatty acids, essential fatty acids such as vitamin A, vitamin B, vitamin B6, vitamin C group, vitamin D group, vitamin E and K group, vitamin F, gelatine, ferulic acid, - orizanol, Vitamin K4, Vitamin P, and vitamins are available.

In addition, spices can be used as the contents. Examples of the spices include pepper tincture, chili oil, nonylic acid vinylamide, kantaris tincture, ginger tincture, ginger oil, peppermint oil, L-menthol, capsaicin and benzyl nicotinate.

Furthermore, it is also possible to use a sunscreen agent, a whitening agent, an enzyme activity lowering agent, a melanin pigment reduction or degradation substance, a cell active substance, an astringent agent, an antioxidant, a lipid peroxide generation inhibitor, an antiinflammator, an antimicrobial disinfecting fungicide, a nonionic surfactant, , Moisturizers, various organic acids, fragrances, and the like can be used as the contents.

For example, encapsulation of fragrance encapsulated in a mask is embedded in the mask to improve the clogging of the nose and volatility can be produced. In addition, it can be applied to disposable articles such as medicines, health foods, foods, cosmetics, and cleaning products

Here, the coating rate may be comprised of 5 to 20%. That is, d / D * 100 = 5 ~ 20. At this time, the radius (D) of the soft capsule is 0.25 to 10 mm, and the thickness (d) of the soft capsule is less than 40 m.

The capsule percentage of the capsule can be made to be not more than 30 탆 when the capsule is used for cosmetics and is made to be not more than 40 탆 when it is prepared mainly for blistering (for example, when it is used as a flavor of tobacco) Lt; RTI ID = 0.0 > um. ≪ / RTI >

The capsule hardness of the capsule is 10 to 50 N or less, preferably 10 to 20 N.

Hereinafter, an experiment of a soft capsule containing starch prepared by the above method as a main component will be described in detail.

[Example 1]

Table 1 below shows the composition of the capsule shell of Example 1 according to the present invention.

number Composition content(%) One
2
3
4 Modified starch
Carrageenan
Calcium alginate
glycerin 60
25
7
8 Sum 100

Preparation of capsules: The content of perfume oil (peppermint oil) was filled into capsules having a thickness of 70 mu m and a diameter of 4 mm to prepare seamless capsules. The prepared capsules were put into a 10% CaCl ₂ solution and converted into calcium alginate (alginate), dried and commercialized. The hardness after drying was measured to be 13N. The digital hardness meter was measured with a Brookfield engineering test machine. The obtained soft capsule was buried in a cigarette, and the sound and feeling of breaking were felt. there was. After 30% CaCl ₂ solution treatment, the dried starch was allowed to stand at 25 ℃ and 85% relative humidity for 10 minutes. The same results as above were obtained.

The obtained soft capsules were cured in a 10% CaCl ₂ solution to be commercialized. There was almost no difference in sensation and sound after putting the capsules in the cigarette filter and leaving them for 10 minutes at 25 ℃ and 85% relative humidity.

[Comparative Example 1] - An example in which an expensive gelatin is used as a main component

Table 2 below shows the composition of the capsule shell of Comparative Example 1 corresponding to Example 1 according to the present invention.

The film composition of Comparative Example 1 Composition table Content (%) Gelatin (gelatin) 75 glycerin 25

As the contents of the capsules, a solution of peppermint oil was packed in capsules having a film thickness of 9.0%, a film thickness of 0.036 mm and a diameter of 4 mm to prepare seamless capsules. The lower the gelatin capsule ratio, the more difficult it was to form capsules.

The hardness of the capsule was 38N, and the number of samples was 20. The soft capsule composition prepared according to Comparative Example 2 was wiped with a finger, but the elasticity was strong. In addition, after 10 minutes' standing at 25 ℃ and 85% relative humidity, the sensation and sound of the capsule in the cigarette filter did not work well due to the deformation of the capsule.

[Comparative Example 2] -Example with dextrin as a main component

Table 3 below shows the composition of the capsule shell of Comparative Example 2 corresponding to Example 1 according to the present invention.

Table showing the composition of capsule shell of Comparative Example 2 Composition Content (%) dextrin 62.2 glycerin 30.0 Carrageenan 7.8

It was attempted to form a seamless capsule with a capsule ratio of 9.0% and a diameter of 4 mm with a solution of the peppermint oil, but the capsule was severely broken during drying and could not be made into a product. That is, it was difficult to form capsules when used as a dextrin material.

[Comparative Example 3] - Example of adding a small amount of starch

Table 4 below shows the composition of the capsule shell of Comparative Example 3 corresponding to Example 1 according to the present invention.

Table showing the composition of capsule shell of Comparative Example 3 Composition Content (%) dextrin 60 glycerin 30 Starch 10

It is difficult to form capsules and it is difficult to form capsules due to moisture absorption.

[Experimental Example 1]

Experimental Example 1 is an experimental example in which the curing agent immersing time required for curing is examined using a curing agent such as calcium ion (used in Example 1) for improving the durability against humidity etc. using the capsule obtained in Example 1.

Storage Time 30 hours 48 hours 240 hours 360 hours Overall assessment Immersion time 1 minute 0/10 0/10 0/10 0/10 ○ Immersion time 10 minutes 1/10 0/10 1/10 2/10 The membrane becomes thin ○. Immersion time 60 minutes 3/10 3/10 3/10 3/10 △

Table 5 shows changes in capsules with storage time after 10% calcium chloride drying.

In Experimental Example 1, 10% CaCl ₂ solution was used as a curing auxiliary aqueous solution after the formation of capsules, and the number of broken samples when the re-dried sample was stored at 45 ° C and 75% relative humidity for a certain period of time. Of 30% CaCl ₂ solution after 1 minute of immersion, at 40 ° C.

The immersion time was about 1 minute, and the longer the immersion time, the less the calcium treatment effect, and the film was dissolved in water, resulting in thinning of the film.

[Experimental Example 2]

Experimental Example 2 (Table 6) was prepared by curing the capsules obtained in Example 1 according to the concentrations of starch and curing agents such as calcium chloride and lactic acid, which were known to be comparatively weak to humidity and the like, and then dried at 40 DEG C for 4 hours into a cigarette filter When comparing popping sensation and sound, the number of defective items is indicated by NG / N number. In other words, the effect of the curing agent concentration on the capsule was shown (the product stability test according to the type of curing agent).

Sample One 2 3 4 5 6 7 8 Remarks water 99 95 90 85 80 75 70 65 Calcium chloride One 5 10 15 25 30 35 Calcium lactate 10 Processing time 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute Whether to re-dry practice practice practice practice practice practice practice practice 25 ℃ 85% 12 hours 3/10 7/10 4/10 5/10 0 0 0 25 ℃ 85% 24 hours 3/10 6/10 5/10 5/10 0 0 0

In Experimental Example 2, the capsule dried after forming the capsule of Example 1 was immersed for 1 minute in an aqueous solution of calcium chloride and calcium lactate, and the calcium chloride composition solution was adjusted to 10% of 30% calcium lactate composition, The capsules after 12 hours of storage and 24 hours of storage under 85% humidity conditions were compared and compared. Concentration of calcium chloride was the most suitable for the fastest rate within 1 minute of 30%, and calcium lactate was not shown in Table 7, and 10% was most suitable. Carrageenan, gelatin and neutralization treatments were used.

[Experimental Example 3]

Experimental Example 3 was carried out in the same manner as in Example 1 except that the capsules prepared in Example 1 were used to obtain better conditions under the condition of the durability of the drying speed and the like, .

Table 7 shows the processing conditions.

Water and ethanol were used for the calcium chloride dissolution solution (comparative experiments based on the hardness of the curing agent, the hardness of the curing agent, and the appearance of the curing agent, relative humidity, etc.)

Curing Treatment Conditions Sample One 2 3 4 5 6 7 8 9 10 Primary treatment water - 20 100 70 70 50 50 40 40 ethanol 100 80 - 30 30 50 50 60 60 Calcium chloride 3 2 3 5 5 3 4 3 3 Processing time 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute 1 minute △ △ ○ ○ ○ ○ ○ △ △

As shown in Table 7, it was confirmed that the higher the ethanol content in the first treatment, the higher the defect rate was.

According to one embodiment of the present invention having the above-described structure, it is possible to provide a soft capsule containing starch as a main component, which is low in cost and excellent in storability, and has high cost, such as gelatin or carrageenan, Can be provided.

According to one embodiment of the present invention, since it is not necessary to use a pH neutralizing agent or the like, the manufacturing process can be simplified.

It is to be understood that the above-described embodiments of the present invention are not limited to the above-described embodiments, and the present invention is not limited to the above-described embodiments, Or some of them may be selectively combined.

Claims (15)

20 to 30% by weight of a viscous modifier comprising 50 to 70% by weight of soluble starch, at least one of carrageenan and gelatin, and 1 to 20% by weight of a humidity controlling agent comprising alginate together with water;
Generating an original capsule through a seamless capsule maker;
The active capsules are immersed in an aqueous solution of a curing agent having a concentration of 10 to 30% of a curing agent containing one of calcium chloride and calcium lactate so as to prevent the soluble starch from being decomposed during the curing treatment so that the alginate and the curing agent undergo a chemical reaction Forming a gel layer on the surface of the aid capsule to cure it; And
And coating the hardened original capsule with a coating liquid to complete a soft capsule.
delete delete The method according to claim 1,
Wherein the content of the alginate in the ingredients of the soft capsule is 20 wt% or less of the soluble starch.
delete The method according to claim 1,
20 to 30% by weight of a viscosity modifier comprising 50 to 70% by weight of the soluble starch, at least one of carrageenan and gelatin, and 1 to 20% by weight of a humidity controlling agent comprising alginate together with water to produce a mixed raw material Quot;
And 1 to 10% by weight of a plasticizer containing glycerin to produce the mixed raw material.
delete The method according to claim 1,
Wherein at least one of waxes, waxes, hardening oil, and HPMC (Hydroxy Propyl Methyl Cellosse) is used as the coating liquid.
A soft capsule comprising starch as a main component, prepared by the method according to any one of claims 1, 4, 6 and 8.
10. The method of claim 9,
Wherein the soft capsule has a coating rate of 5 to 20%, the soft capsule comprising starch as a main component.
10. The method of claim 9,
Wherein the soft capsule has a diameter of 0.5 to 20 mm.
10. The method of claim 9,
Wherein the soft capsule has a thickness of less than 60 占 퐉.
A second component consisting of 20 to 30% by weight of a mixture of carrageenan, gelatin or a mixture of carrageenan and gelatin, 1 to 20% by weight of alginate, and a third component consisting of glycerin 1 To 10% by weight of a fourth component,
A starch composition comprising a gel layer formed by a chemical reaction with a curing agent aqueous solution having a concentration of 10 to 30% of a curing agent containing one of calcium chloride and calcium lactate so that the soluble starch is not decomposed during curing treatment Soft capsules made of the main ingredient.
delete 14. The method of claim 13,
And a coating layer formed on the gel layer.

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