KR101442814B1 - Penial prosthesis - Google Patents

Abstract

The present invention relates to a penile prosthesis and, more specifically, to a penile prosthesis that helps one to lead a healthy sex life by having the diameter of a penis enlarged as the penile prosthesis is inserted between the foreskin and corpus cavernosum. A penile prosthesis of the present invention has few side effects while the same can be simply transplanted under the skin, and can be easily applied in a surgical operation for penis enlargement satisfying requests of various types of patients as the prosthesis is able to overcome limits of thickness required for engrafting penis enlargement materials such as an existing transplant of hypodermis or the like.

Description

{PENIAL PROSTHESIS}

The present invention relates to a penis implant, and more particularly, to a penis implant that can be inserted between the epidermis of the penis and the corpus cavernosum, thereby effectively increasing the diameter of the penis, thereby contributing to a healthy sexual activity.

In general, male erection is known to be a conditional reaction phenomenon caused by the complex action of various organs of the body due to the will of the patient, mental stimulation or physical stimulation. Such erectile symptoms are caused by the central nervous system such as the endocrine system, the vascular system, And the local conditions of the penis.

These erectile symptoms are very important for healthy sex life, but they can cause sexual dysfunction due to direct injuries of body parts such as industrial accidents and traffic accidents. In addition, factors related to adult diseases such as stress, changes in eating habits, Sexual dysfunctions of men due to psychological factors are increasing.

In particular, men generally feel severe psychological atrophy for a relatively small penis size, which may be due to mental factors.

When sexual dysfunction occurs, males lack confidence in many aspects of daily life as well as sexual intercourse, and these stresses may lead to disruptive social life.

In order to overcome male sexual dysfunction, medication or psychotherapy may be performed. However, in cases where it is difficult to obtain the effect of only medication or psychotherapy, it may be very effective to perform the procedure for enlargement of the penis, There are a variety of procedures for.

Penile enlargement procedures are typically fat grafts, skin grafts such as autologous dermis, filler injections, and procedures using heterologous dermis and allogeneic dermis.

Fat transplantation is a relatively simple method of transplanting the fat from the recipient's fingers to the penis, but there may be a disadvantage that the fat is absorbed over time, and the filler injection does not dissect the penis, The product can be injected into a syringe without the necessity of taking the product, and there is a merit that the operation is easy. However, the injected filler component may be absorbed into the body over time.

 The skin grafting is performed by taking the skin of the recipient, that is, the dermal tissue of the recipient, but there may be a problem that the wound remains largely on the tissue harvesting site, the transplanted skin does not grow, and necrosis occurs.

The dermis and the dermis of the same species can be easily implanted in the subcutaneous tissue while the side effects are few, the absorption into the body is hardly performed, the semi-permanent, and because the penis enlargement can be performed in a homogeneous thickness, Therefore, it is necessary to study various implants that can effectively meet the needs of various patients.

KR 10-2003-0076028 US 2010/0043807 KR 10-0507760 KR 10-2001-0092985 KR 10-2001-0096388

The present invention aims to provide a penile implant that can be easily implanted subcutaneously, has few side effects, and can effectively respond to the needs of various patients.

The present invention relates to a dermal tissue graft; A collagen membrane located below the dermal tissue graft and having a corner coupled with the dermal graft implant to form a space with the dermal graft; And a filler injected into a space between the dermal tissue graft and the collagen membrane.

The present invention also relates to a cosmetic comprising a collagen membrane; A columnar block defined by the collagen film and having a length of 4 to 5 cm and a width of 5 to 10 mm, the cross section of which is a convex lens shape or an elliptical shape; And a filling body inserted into the columnar block partitioned by the collagen film; The columnar blocks are connected side by side in three to seven widthwise directions to provide a penile implant having a length of 4 to 5 cm and a width of 6 to 7 cm.

Since the penile implant of the present invention can be easily implanted subcutaneously and has a small side effect and can overcome the limit of the thickness of the penis enlargement material such as the implant composed only of the conventional dermal tissue graft, And can be easily applied to penis enlargement procedures.

1 schematically illustrates a penile implant according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view of a penis enlarged using a penis implant according to an embodiment of the present invention.
FIG. 3 schematically illustrates a process of manufacturing a penile implant according to an embodiment of the present invention. Referring to FIG.
FIG. 4 is a front view, a plan view, a side view, and a perspective view schematically showing a penis prosthetic according to another embodiment of the present invention.
FIG. 5 is a schematic view illustrating the shape of a penis enlarged using a penis implant according to another embodiment of the present invention.

The penile implant of the present invention comprises a dermal tissue graft; A collagen membrane located below the dermal tissue graft and having a corner coupled with the dermal graft implant to form a space with the dermal graft; And a filling body inserted into a space between the dermal tissue graft material and the collagen membrane.

In addition, the penile implant of the present invention comprises a sheath composed of a collagen membrane; A columnar block defined by the collagen film and having a length of 4 to 5 cm and a width of 5 to 10 mm, the cross section of which is a convex lens shape or an elliptical shape; And a filling body inserted into the columnar block partitioned by the collagen film; The columnar blocks are connected side by side in three to seven in the width direction to have a length of 4 to 5 cm and a width of 6 to 7 cm.

The terminology used herein is for the purpose of describing exemplary embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, the terms "comprising," "comprising," or "having ", and the like are intended to specify the presence of stated features, But do not preclude the presence or addition of one or more other features, integers, steps, components, or combinations thereof.

Also in the present invention, when referring to each layer or element being "on" or "on" each layer or element, it is meant that each layer or element is formed directly on each layer or element, Layer or element may be additionally formed between each layer, the object, and the substrate.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

A penile implant according to one aspect of the present invention comprises a dermal tissue graft; A collagen membrane located below the dermal tissue graft and having a corner coupled with the dermal graft implant to form a space with the dermal graft; And a filling body inserted into a space between the dermal tissue graft material and the collagen membrane.

Generally, implants for penile enlargement include collagen, a filler mixed with powdered stored dermis and physiological saline, and a filler material including fat and the like, a dermis material containing allogeneic dermis and dermis, Gel or the like, and the like are often used.

The filler-based material including collagen, powdered stored dermis and physiological saline, and filler-based material including fat are injected subcutaneously into the penis directly by a syringe to enlarge the thickness of the penis. And there is no need for a separate incision at the injection site, so that the recovery is quick and the feeling of volume felt by the physician immediately after the procedure is excellent. However, when the filler is implanted, it is injected directly into the target site with a syringe. Therefore, it is difficult to perform the enlargement operation with a uniform thickness, and granules may be formed in the treatment site after the procedure, side effects such as asymmetry may occur, There is a drawback that the rigidity is lower than that of the material.

The silicon-based material can be enlarged in the thickness of the penis by cutting the skin of the penis into a whaling line, wrapping the outer surface of the sponge with a prepared silicone material, and sealing the skin. The price is low, and volume and stiffness are good after the procedure, but there is a disadvantage that it is impossible to engage in the penis tissue.

Accordingly, a penile implant according to an aspect of the present invention includes a dermal tissue graft.

According to an embodiment of the present invention, the dermal tissue graft may be an alternative dermal tissue graft containing allogeneic dermis or heterogeneous dermis, and the allogeneic dermis preferably includes acellular dermal matrix can do.

The cell-free allogeneic dermis tissue may be prepared by the following method, but the present invention is not limited thereto. In general, the cell-free allogeneic dermis tissue used in the biomedical field can be used without any particular limitation.

First, prepare a tissue to be used as an implanted material. The tissue to be used as a transplant may be isolated from the donated body, and when transported separately from the body, tissue damage due to hypoxia, degradation by autolytic enzymes, damage of extracellular epilepsy by proteolytic enzymes, Damage, microbial contamination such as bacteria or fungi. Therefore, it is necessary to add a substance that can prevent degradation by hypoxia, decomposition by autolytic enzyme, degradation by protein and decomposition enzyme, and antibiotics and antimicrobial agent which can prevent microorganism contamination Should be added.

The osmotic pressure of the tissue delivery solution may be desired to have an osmotic pressure of about 260 to about 320 mOsm / kg, the osmotic pressure of the plasma. In the case of commercial medium, which is widely used for animal cell culture, osmotic pressure is about 260 to about 320 mOsm / kg, which is similar to osmotic pressure of plasma. Thus, it may be desirable to use commercial medium as the base solution.

In order to prevent contamination of bacteria and fungi, antibiotics such as penicillin, streptomycin, kanamycin, neomycin, bacitracin, gentamicin, vancomycin and the like, and antimicrobial agents such as amphotericin-b, nystatin, Or in combination.

In addition, enzyme inhibitors are added to prevent tissue damage by various degrading enzymes. Enzyme inhibitors include N-ethylmaleimide (NEM), phenylmethylsulfonyl fluoride (PMSF), ethylenediaminetetraacetic acid (EDTA), ethylene glycol-bis '-Tetraacetic acid (EGTA) and the like, protease inhibitors such as lupeptin, apoproteinin and the like can be used.

It may also be desirable to carry it at low temperature to minimize the enzyme reaction. Most enzymatic reactions are highly influenced by temperature, and most active at 37 ° C, which is human body temperature, so it is preferable to carry them at a low temperature of about 4 to about 10 ° C. If the temperature is too low, tissue damage may occur by ice crystals. If the temperature is too high, tissue damage may occur due to the enzyme reaction.

The skin layer and the dermal layer are separated from the prepared tissue as described above. In general, various proteolytic enzymes are used to separate the dermal layer and the epidermal layer. When enzymes are used, if the concentration is too low or if the treatment time is too short, the separation can not be performed well. If the concentration is too high or the treatment time is too long, the cells or tissues will be damaged. Therefore, it should be treated according to appropriate concentration and time.

As the enzymes used for separating the dermal layer and the epidermal layer, there may be used neutral protease such as Dipassa, Tramolysin, Trypsin and the like. Treatment is carried out at about 37 ° C for about 60 to about 120 minutes using a depressant at a concentration of about 1.0 units / ml, or about 30 minutes at about 37 ° C using about 200 μg / ml tramolysin The dermal layer and the epidermal layer can be separated. Tramolysin has the advantage of lowering the risk of basement membrane damage compared to using dipase.

After removing the skin layer by the above-mentioned method, the cells of the dermal layer are removed. The membrane protein, which is mainly present in the cell membrane, can cause an immune response, and thus can be a main cause of side effects such as rejection of transplantation after transplantation. Therefore, it is desirable to remove the cells to reduce side effects after transplantation. At this time, it is possible to use a method of selectively removing the cells without damaging the tissue using the difference in physical and chemical properties between the cells and the extracellular matrix.

Since the main component of the cell membrane is phospholipid, cells can be removed without damaging the tissue using a surfactant or the like. Ionic surfactants such as, for example, sodium dodecyl sulfate, or ionic surfactants such as Triton X 100, Tween 20, Tween 40, Tween 60, Tween 80, Nonidetip-10 (NP-10) -40), and the like can be used.

Specifically, the dermal layer is treated with a solution of sodium dodecyl sulfate at a concentration of about 0.2 to about 1% at room temperature for about 30 to about 120 minutes, or treated with a solution of Tween 20 at a concentration of about 0.1 to about 2.0% for about 30 to about 180 minutes at room temperature Or by treatment with a Triton X-100 or Nonidt P-40 solution at a concentration of about 0.2 to about 2% at about 22 to about 37 for about 30 to about 180 minutes.

In addition, the dermal layer may be treated with ultrasonic waves of about 10 to about 100 kHz for about 5 to about 60 minutes to remove the cells without damaging the tissue.

In addition, it may be desirable to remove the basement membrane layer after removing the cells from the dermal layer. When the basement membrane layer is removed, the transplantation can be made more stable by increasing the inflow of the fibroblast and promoting the renal vasculogenesis action, thereby increasing the rate of engraftment to the skin.

The dermal layer with the cells removed is then stored in a freeze solution. The freezing solution consists of a buffer solution to maintain the ionic strength or osmotic pressure of the solution, a cryoprotectant to prevent the physical and chemical damage of the dermal layer tissue during freezing, and a dry protective agent to prevent the structural change of the dermal layer structure upon drying.

The cryoprotectant enhances the stability of frozen tissue by increasing the glass transition temperature of the dermis layer. The higher the glass transition temperature, the higher the specific gravity of glassy or square ice, which has a less stable structure than the hexagonal ice in the structure, and the drying speed can be further increased. In addition, glassy and square ice can minimize the damage of the tissue due to the small size of the ice. Examples of the cryoprotectant include dimethylsulfoxide (DMSO), dextran, sugar, propylene glycol, glycerol, mannitol, sorbitol, fructose, trehalose, raffinose, 2.3-butanediol, hydroxyethyl starch (HES), polyethylene glycol, polyvinylpyrrolidone (PVP), proline, hetastarch, and serum albumin. By combining these components with various base components, a freeze solution is prepared and used. Among them, dextran, glycerol, hetastachil, mannitol, and ethylhydroxy starch are used as serum substitutes, and polyethylene glycol is also used as a stabilizer for monoclonal injections, and its stability has been confirmed to some extent. As such, the frozen solution is made mainly of materials known to be harmless to human body. Immerse the dermis layer in the prepared frozen solution and allow the frozen solution to penetrate well using an appropriate method.

The dermal layer in which the frozen solution is impregnated is stored in a cold freezer at about minus 40 to minus 70 < 0 > C. It is preferable to carry out freeze-drying for about 24 hours to about 50 hours by moving to a freeze-dryer after freezing for about 12 hours to about 48 hours.

Cell-free allogeneic dermal tissues can be prepared by the above-mentioned method. For example, megadum (manufactured by ELN Cibio), Schwartz (manufactured by Hans Biomed), etc. may be used as a commercially available product .

It may be desirable for the dermal tissue grafts to have the corners of the upper end tapered. For example, the surface of the rectangular dermal tissue graft terminal is gently treated to form a sloped surface. At this time, it is possible to form an inclined surface by gently treating one edge or all edges as needed. The height of the dermal tissue graft after tilting may preferably be from about 50 to about 85% as compared to the height of the grafted previous graft, and the tilt angle may be preferably from about 30 to about 45 degrees. When the inclination height and the inclination angle of the dermal tissue graft are in the above range, it is difficult to distinguish the inserted interface when inserted into the penis implant, and the aesthetic effect can be excellent. In addition, the lower part of the urethra or the glans lower part of the penis So that the incidence of side effects due to the penis enlargement procedure can be minimized.

This dermal tissue graft is a material that can dissect the skin of the penis into a whaling line and then wrap it around the outer surface of the spongy body and enlarge the thickness of the penis by suturing the skin again. In addition, when a cell-free allogeneic dermis tissue is used, it is possible to minimize side effects after transplantation by engaging in penile tissue.

However, dermal tissue grafts are very expensive, and when used as a penile implant, there is a limit to the thickness that can be applied to the subject due to problems such as engraftment, and the volume feeling at the beginning of the procedure is poor compared to the liquid filler materials such as fat There are disadvantages.

Accordingly, a penile implant according to an aspect of the present invention includes a collagen membrane positioned below the dermal tissue graft and having a corner connected to the dermal tissue graft to form a space with the dermal graft; And a filling body inserted into a space between the dermal tissue graft material and the collagen membrane.

Generally, it is difficult to enlarge the penis to a uniform thickness when the filling body is used as a penis implant. However, in the case of the present invention, a filling body is inserted into a certain space divided into a dermal tissue graft and a collagen membrane It is possible to enlarge the penis with a uniform thickness.

In addition, in the case of using only the dermal tissue graft, there may be a limitation in the enlarged thickness due to problems such as the engraftability of the graft and the feeling of volume felt by the recipient after the procedure, It is possible to enlarge the penis in a thick form, and to easily adjust the enlargement thickness according to the demand of the physician, and it is possible to give an excellent volume feeling at the initial stage of the procedure rather than using only the dermal tissue graft.

The collagen membrane may form a space between the sponge body of the subject and the dermal tissue graft under the dermal tissue graft, i.e., during the penis enlargement procedure, so that the filling material having a uniform thickness may be injected. In addition, the collagen membrane directly contacts the sponge body, which can promote hemostasis and coagulation, and can promote re-epithelization by increasing the differentiation and proliferation of injured epithelial cells due to the procedure, and the proliferation, migration, And can induce the formation of new granulation tissues by the help of the generation, so that the recovery period after dilation can be drastically shortened compared with the case of using only general dermal tissue graft.

With the collagen membrane, the inserted filler body can not be moved to other factors such as external stimuli after the procedure, and can provide excellent volume feeling. The collagen membrane may vary depending on the thickness of the membrane or the method of operation, For example, after about 14 days to 28 days, it is absorbed into the living body, and the charged filling material can be naturally transferred to the penis tissue after absorbing the collagen membrane.

According to an embodiment of the present invention, the collagen membrane may include atelocollagen from which telopeptide has been removed, the atelocollagen may be obtained from type 1 collagen, and the collagen membrane may have a thickness of 0.5-1.0 mm It is preferable that the film is provided. In addition, the collagen membrane may further comprise hyaluronic acid.

Collagen is the main protein component of the extra-cellular matrix. It constitutes hard tissues such as bones and teeth as well as soft tissues including connective tissues such as skin, tendons, and blood vessels, and forms the basic structure of tissues and organs . The type of collagen varies from tissue to tissue. In particular, type 1 collagen is most widely used in the field of biotransplantation because it is contained in a large amount in almost all tissues such as skin, ligament, and bone. At the both ends of the type 1 collagen molecule, there are telopeptides that do not form a spiral, which may be a main cause of the immune reaction during transplantation of the living body, so it is preferable to use the atelocollagen from which this part is removed.

The collagen film may be prepared by the following method. First, about 1 to about 5 wt% of atelocollagen is added to distilled water, and the mixture is stirred at about 4 to about 10 DEG C for about 12 to about 30 hours to prepare a dispersion. About 0.1 to about 1 M NaOH is added to the dispersion to adjust the pH to a range of about 7 to about 7.5. When the hyaluronic acid is added, about 1 to 5 wt% of a hyaluronic acid aqueous solution is added to the dispersion before the pH adjustment at about 10 to 20 parts by weight based on 100 parts by weight of the dispersion, homogenized, and then the pH is adjusted to about 7 to about 7.5 . This is spread on a release plate to adjust the thickness to about 0.5 to 1.0 mm and lyophilized at about -60 to -80 캜 for about 30 hours to prepare a membrane.

According to another embodiment of the present invention, the filler may be a filler mixed with collagen, powdered dermis and physiological saline, or fat. The collagen to be used as a filler is as described in the atelocollagen of the collagen membrane, and a fluid type of atelocollagen can be used. The filler mixed with the powdered preserved dermis and the physiological saline can be prepared by mixing the powdered homologous dermis (e.g., Megafil, Merck & Co., Inc., LNVI Bio) and physiological saline at a ratio of about 1: 0.5 to about 1: 1.5 By volume, and further, an antibiotic may be further added thereto if necessary.

According to another embodiment of the present invention, it may be preferable that the dermal tissue graft have a length of about 6 to about 7 cm, a width of about 4 to about 5 cm, and a thickness of about 3 to about 5 mm , It may be desirable that the collagen membrane is located in the lower center of the dermal tissue graft with a width of about 80 to about 95% of the dermal graft. The filling material is injected so that the space formed between the dermal tissue graft and the collagen membrane has a thickness of about 3 to about 4 mm, resulting in a thickness of about 6 to about 9 mm. , It may be desirable to increase the possibility of engraftment, but the present invention is not limited thereto and can be suitably adjusted in accordance with the physical condition of the person to be treated or to meet the requirements of the subject.

1 schematically illustrates a penile implant according to an embodiment of the present invention.

Referring to FIG. 1, a penile implant according to an embodiment of the present invention includes a dermal tissue graft 100; A collagen membrane 300 located below the dermal tissue graft and having a corner coupled with the dermal graft 100 to form a space with the dermal graft; And a filler (200) charged into a space between the dermal tissue graft (100) and the collagen membrane (300). A detailed description thereof is as described above.

FIG. 2 is a cross-sectional view of a penis enlarged using a penis implant according to an embodiment of the present invention.

2, the penis 400 directly contacts the collagen membrane 300 of the penis implant of the present invention, and the filler body 200 is inserted between the collagen membrane 300 and the dermal tissue graft 100 And the dermal tissue graft 100 is present on the outside thereof. The sutures can be made after the incised skin above the transplanted penile implant is covered.

Also, as can be seen in FIG. 1, the penis is wrapped with the diving tissue graft 100 in an inclined form, so that the compression of the urethra can be reduced, and the enlargement operation can be performed in a natural shape of the interface.

The implant according to one aspect of the present invention can be manufactured by the following method. Placing the collagen membrane under the dermal tissue graft and applying a pressure of about 10 to about 20 psi at a temperature of about 50 to about 100 캜 to a corner portion where the collagen membrane and the dermal tissue graft are joined, To the lower portion of the dermal tissue graft.

In addition, a corner of the collagen membrane may be joined to the dermal tissue graft using a tissue adhesive commonly used in surgery for intra-human internal joining, and may be fixed to a lower portion of the dermal graft.

Examples of usable tissue adhesives include fibrin-based tissue adhesives, gelatinous tissue adhesives, collagen-based tissue adhesives, albumin-based tissue adhesives, mussel-derived protein-based tissue adhesives, or polylysine- Tran type tissue adhesives, and the like. However, the present invention is not limited thereto, and it is possible to use a tissue joining agent having safety for internal use in the body such as biodegradability and toxicity without any particular limitations.

Alternatively, the collagen membrane may be placed under the dermal tissue graft, and the corners where the collagen membrane and the dermal tissue graft are joined may be sealed with an absorbable suture.

According to another aspect of the present invention, there is provided a penis prosthesis comprising: a skin comprising a collagen membrane; A columnar block defined by the collagen film and having a length of about 4 to about 5 cm and a width of about 5 to about 10 mm, the cross-section of which is a convex lens shape or an elliptical shape; And a filling body inserted into the columnar block partitioned by the collagen film; The columnar blocks are connected side by side in three to seven in the width direction to have a length of 4 to 5 cm and a width of 6 to 7 cm.

Here, the length of the columnar block means the height of the columnar shape formed in the direction perpendicular to the end face of the columnar block, and the width of the columnar block means that the width And the thickness of the columnar block means a length in a direction perpendicular to the width of the columnar block.

The structure of the penis implant will be described as follows. First, the penis implant includes a sheath composed of a collagen membrane. The description of the collagen membrane is as described above. The outer shape of the penis prosthesis can be formed by the sheath composed of the collagen membrane, and a specific amount of the filling material can be used as a penis implant as an enlargement procedure.

Since the filler and the like are generally directly injected into the penis by a method such as injection, it is difficult to uniformly inject the same, and after the injection, the penis can be absorbed into the biotissue at a different ratio at each site, There is a problem in that a problem occurs.

Since the penis implant of the present invention has an outer shape formed by a sheath composed of a collagen membrane, a specific amount of filler can be effectively injected according to the physical condition or requirements of the physician.

The collagen film is replaced with the above description.

The penile implant of the present invention also includes a columnar block defined by the collagen membrane and having a length of about 4 to about 5 cm, a width of about 5 to about 10 mm, and a cross-section of which is convex lens or elliptical do. These columnar blocks may be connected side by side in three to seven widthwise directions to form a penile implant having a length of about 4 to about 5 cm, and a width of about 6 to about 7 cm.

In addition, it is preferable that the outer portion of the columnar block having 3 to 7 connected widthwise portions of the penis implant has a flattened collagen membrane, and when applied to an actual procedure, It is possible to easily suture the region to be treated.

Figure 4 schematically illustrates a penile implant according to another aspect of the present invention.

4, the penile implant of the present invention comprises a columnar block having a length of about 4 to about 5 cm, a width of about 5 to about 10 mm and a cross-section of a convex lens or an ellipse, (610), and such columnar blocks (610) are connected side by side in three to seven widthwise directions to form a penis implant having a length of about 4 to about 5 cm, and a width of about 6 to about 7 cm Can be formed.

The number of the connection of the columnar blocks may be three or seven connected in parallel depending on the physical conditions and requirements of the client, and it is preferable to use the penis implant having five columnar blocks connected in the width direction, It may be desirable to perform the enlargement procedure with different thicknesses.

Since these columnar blocks are each partitioned by the collagen membrane, they have respective distinct internal spaces. Thus, the filler may be injected in the same amount or in different amounts so that the maximum thickness of each of the blocks partitioned by the collagen membrane is about 3 to about 4 mm. Here, the maximum thickness refers to the thickness of the ellipsoidal portion, which is the thickest in the cross-sectional shape of the convex lens or the elliptical shape due to the filling body and the collagen film after the filling body is filled in the columnar block.

By this method, the same amount of filler or different amount of filler can be injected into each column block, and according to the physical conditions of the client and the demand of the client, An operation can be performed so that each portion can be enlarged to a different thickness.

FIG. 5 is a schematic view illustrating the shape of a penis enlarged using a penis implant according to another embodiment of the present invention.

Referring to FIGS. 4 and 5, it can be seen that the procedure progresses so that the longitudinal direction of the columnar block 610 of the penile implant 600 surrounds the penis 500.

When using a penis prosthesis in which five columnar blocks partitioned by the collagen membrane are arranged side by side in a width direction, the longitudinal direction of the columnar block wraps the penis, or the width direction of the columnar block encloses the penis Depending on the physical condition of the physician and the requirements of the physician, for example, a large amount of filling material may be applied to the columnar block, which is present at the 2/5 or 3/5 position from the tip of the penis And the remaining portion is filled with a small amount of filler so that enlargement can be performed so that each portion of the penis can be formed to have a different thickness.

Specifically, a different amount of filler is injected into the columnar block such that the maximum thickness of the columnar block into which the least amount of filler is charged is about 40 to about 80% of the maximum thickness of the columnar block being charged in the largest amount .

Generally, when a filling material such as a filler is injected using a syringe or the like, it can be injected directly to a desired site. However, after the operation, there is a possibility of moving in the tissue by external stimulation or the like, And the filler material is absorbed at a high rate within the tissue.

According to the present invention, since the filling body can be fixed by the respective columnar blocks, a desired number of filling bodies can be put in a desired position, and a precise enlargement can be made in a desired form with respect to the physical conditions and requirements of the client In addition, since the collagen membrane can prevent absorption of tissue inside the initial filler material, a more efficient enlargement procedure can be achieved.

The collagen membrane is directly contacted with the spongy body inside the penis during the enlargement of the penis. At this time, the collagen membrane can promote the hemostasis and coagulation, and can promote the re-epithelization by increasing the differentiation and proliferation of damaged epithelial cells Since it can induce proliferation, migration, and production of fibroblasts and induce new granulation tissue formation, the recovery period after enlargement can be significantly shortened compared with the case of using a general implant.

The collagen membrane is absorbed into the living body after a certain period of time, for example, about 14 to 28 days after the operation, and the filled body can be naturally transferred to the penis tissue after absorbing the collagen membrane.

According to an embodiment of the present invention, the filler may be a filler mixed with collagen, powdered dermal and physiological saline, or fat.

Further, according to another embodiment of the present invention, the penis implant may further include a dermal tissue implant on the upper part thereof. By including the dermal tissue graft, it is possible to further increase the stiffness of the enlarged penis, and to minimize the thickness reduction ratio due to the absorption of the filling material after the procedure. The dermal tissue graft can be transferred to the penis tissue after the procedure, and a detailed description thereof is as described above.

Such a penile implant may be prepared by the following method. First, prepare two sheets of collagen film having a length of about 4 to about 5 cm, and a width of about 6 to about 7 cm. After the two sheets of collagen films are superimposed to overlap each other, a portion of the columnar block is selectively applied at a temperature of about 50 to 100 DEG C and a pressure of about 10 to 20 psi, 0.0 > a < / RTI > shaped block can be made.

In addition, a single collagen membrane is prepared, and a tissue adhesive agent commonly used for intra-body bonding or the like is applied selectively to the part of the columnar block, which is then covered with the remaining one piece of collagen film, By applying a constant pressure and allowing the pressurized portions to adhere, a penile implant with a certain type of columnar block can be made. The tissue bonding agent is as described above.

< Example >

Manufacture of penile implant

A collagen membrane (trade name: Coladum, manufactured by Bioland Co., Ltd.) and a 3.5 cm-long, 3.5 cm-wide collagen membrane (product name: Megadum; (Trade name: Megafil, manufactured by ELEC Bio Inc.) was prepared. The filling material was prepared in a liquid state by dissolving in physiological saline solution for injection.

The collagen membrane was placed in the lower center of the dermal tissue graft and then bonded to the corners of the membrane at a temperature of about 70 DEG C and a pressure of about 15 psi using a tissue adhesive. Injecting a filling material into a space between the dermal tissue graft material and the collagen membrane using a syringe to form a dermal tissue graft; A collagen membrane located below the dermal tissue graft and having a corner coupled with the dermal graft implant to form a space with the dermal graft; And a filling body inserted into a space between the dermal tissue graft and the collagen membrane. The size of the manufactured penis was 5 cm in length, 5 cm in length, and 7 mm in thickness.

FIG. 3 schematically illustrates a process of manufacturing a penile implant according to an embodiment of the present invention. Referring to FIG.

3, a filling material is injected into a space between a dermal tissue graft and a collagen membrane using a syringe to form a dermal tissue graft, a collagen membrane, and a collagen membrane, The penis implant can be identified.

100: dermal tissue graft
200: filled body
300: Collagen membrane
400: Penis
500: Penis
600: penile implant
610: Columnar block

Claims (12)

Dermal tissue graft;
A collagen membrane located below the dermal tissue graft and having a corner coupled with the dermal graft implant to form a space with the dermal graft; And
A filler charged into a space between the dermal tissue graft and the collagen membrane;
0.0 &gt; a &lt; / RTI &gt;
The method according to claim 1,
Wherein the dermal tissue graft is an alternate dermal tissue graft comprising a homologous dermis or heterologous dermis.
3. The method of claim 2,
Wherein said allogenic dermis comprises acellular dermal matrix.
The method according to claim 1,
Wherein the collagen membrane comprises atelocollagen and hyaluronic acid.
The method according to claim 1,
Wherein the filled body is a filler mixed with collagen, powdered stored dermis and saline, or a penile implant including fat.
The method according to claim 1,
The dermal tissue graft has a length of 4-5 cm, a width of 6-7 cm, and a thickness of 3-5 mm,
Wherein the collagen membrane is positioned at a lower center of the dermal tissue graft with a width of 80% to 95% of the dermal graft,
Wherein the filling body is inserted so that the thickness of the space formed between the dermal tissue graft and the collagen membrane is 3 to 4 mm.
A skin consisting of a collagen membrane;
A columnar block defined by the collagen film and having a length of 4 to 5 cm and a width of 5 to 10 mm, the cross section of which is a convex lens shape or an elliptical shape; And
And a filling body inserted into the columnar block partitioned by the collagen film;
Wherein the columnar blocks are connected side by side in three to seven widthwise directions, with a length of 4 to 5 cm, and a width of 6 to 7 cm.
8. The method of claim 7,
Wherein the columnar blocks are arranged side by side in a width direction.
8. The method of claim 7,
Wherein the filler is injected in the same amount or in different amounts so that the maximum thickness of each of the blocks partitioned by the collagen membrane is 3 to 4 mm.
8. The method of claim 7,
Wherein the filler is injected in different amounts into the columnar block defined by the collagen film,
A penile implant having a maximum thickness of 40 to 80% of the maximum thickness of a columnar block loaded with the greatest amount of the least amount of columnar block.
8. The method of claim 7,
Wherein the filled body is a filler mixed with collagen, powdered stored dermis and saline, or a penile implant including fat.
8. The method of claim 7,
A penile implant further comprising a dermal tissue graft on top.

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