KR101414806B1 - Closed-loop deep brain stimulation system for gait correction of patients - Google Patents

Abstract

The present invention relates to a closed-type cerebral and cerebral stimulation system for measuring and correcting a patient's step, and a method for implementing the same. More specifically, the present invention relates to a closed- In order to be able to do this, we measured the gait of the patient who had symptoms of gait disorder such as Parkinson's disease. If there is an abnormality, the appropriate stimulus is given through Deep Brain Stimulation (DBS) To a system capable of correcting hooks.

Description

[0001] CLOSED-LOOP DEEP BRAIN STIMULATION SYSTEM FOR GAIT CORRECTION OF PATIENTS [0002]

The present invention relates to a closed-type stimulation system for measuring and correcting a patient's pace, and more specifically, to enable a more accurate diagnosis and correction by detecting a patient's symptoms directly in the living and controlling the degree of stimulation , A patient with a symptom of gait disorder, such as Parkinson's disease, is measured. If there is an abnormality, Deep Brain Stimulation (DBS) device can be used to correct the patient's gait Lt; / RTI >

According to the Health Insurance Review and Assessment Service, the number of patients with Parkinson's disease, one of the degenerative brain diseases caused by the aging of the Korean population, has doubled in 2008 compared to 2004, and the number of patients aged 4 to 50 has increased by about 40%.

Deep Brain Stimulation (DBS) is an implantable device that alleviates symptoms of diseases such as Parkinson's disease by applying electrical stimulation to specific areas of the brain. It is used to determine how electrical stimulation inhibits symptoms such as tremors in the limbs The precise principle for FDA has not yet been clarified, but since 2002, FDA approval has been in effect.

Since the cerebellum stimulation system has been developed for the first time, various methods have been proposed to precisely control the stimulation parameters by feedback. Typically, it is proposed to measure electric or chemical signals in an electrode implanted in a patient's brain or to light the patient's brain, and then to grasp the activity of the brain based on the shape of the reflected light to control the degree of stimulation.

However, these methods have a problem in that it is difficult to diagnose the accurate state of the patient and determine the proper intensity of the stimulation by the present technology because a lot of noise is mixed in the obtained signal.

In addition, patients suffering from Parkinson's disease have symptoms of tremors and uncomfortable feet. In order to alleviate these symptoms, a cerebral and cerebral stimulation system has been developed, but the parameters of the cerebellum stimulation system are turned off or the degree of electrical stimulation is appropriate In addition, there is a problem that the symptoms of the patient may appear again when the patient is not using the device. Especially, when the patient with Parkinson's disease implanted with the cerebellum stimulation system suddenly appears when the patient goes out, the patient's behavior becomes uncomfortable, do.

Korean Published Patent Application No. 10-2012-0043694 (published on May 4, 2012).

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, And provides a closed cerebral cerebral stimulation system capable of more accurate diagnosis and correction by controlling the degree of stimulation.

In addition, the present invention measures the gait of a patient who has a symptom of gait disorder such as a patient with Parkinson's disease, and when the gait is abnormal, a proper stimulation is provided through Deep Brain Stimulation (DBS) And the like.

In addition, the present invention enables a closed-type cerebral and cerebral stimulation system to be implemented using a portable terminal such as a smart phone carried by a patient, so that it is easy to carry and has a simple structure and maximizes data processing, transmission and storage functions Lt; RTI ID = 0.0 > cerebellar < / RTI > stimulation system.

The closed cerebellar stimulation system according to an embodiment of the present invention for solving the above technical problems is a closed cerebral cerebral stimulation system for measuring and correcting a step of a patient having a symptom that is abnormal in gait, Deep Brain Stimulation (DBS), which applies a stimulus to the patient's brain to correct the gait of the patient who has been implanted; A measuring device for measuring the gait of the patient; And a controller for determining whether or not a patient has a gait on the basis of the gait of the patient measured by the measuring device, and transmitting stimulus variable information for calibrating the gait of the patient to the cerebellum stimulating device if there is an abnormality. .

Preferably, the measuring device includes a sensor unit including a plurality of pressure sensors for measuring a pressure value at a predetermined position of the foot in accordance with a patient's walking, and a transmitter for transmitting the pressure value measured by the sensor unit to the control unit .

The control device may further include: a receiving unit that receives the pressure value transmitted from the transmitting unit; Determining whether the patient is walking based on the plurality of pressure values received by the receiving unit, determining whether the patient is walking on the basis of the determined gait state of the patient, Determining a stimulus variable information for correcting the state if the abnormality is present, and transmitting the determined stimulus variable information to the cerebellum stimulation apparatus; And a database unit in which the stimulus parameter information is stored for each of the gait states of the patient having the abnormality, wherein when the gait state of the patient having the abnormality is stored in the database unit And when the gait state of the patient having the abnormality is not stored in the database, the stimulus variable information stored in the database unit is transmitted to the cerebellum stimulation apparatus, Information can be transmitted to the cerebellum stimulating apparatus.

Preferably, the control unit continuously receives the pressure value received from the receiving unit to determine a gait state of the patient, and determines whether the patient's gait correction based on the stimulus variable information is corrected based on the patient's gait state And transmits a signal for stopping the operation of the cerebral and cerebral stimulation apparatus to the cerebellum stimulation apparatus when correction is made as a result of the determination, The stimulus variable information may be transmitted to the cerebellum stimulation apparatus.

Preferably, when the patient's gait is corrected by the new stimulus variable information, the controller may store the new stimulus variable information in the database as stimulus variable information for correcting the gait state of the patient having the abnormality have.

Preferably, the controller may transmit a notification signal to a predetermined guardian or a primary caregiver when the patient's gait is not corrected for a predetermined period of time.

The control device is a portable terminal carried by a patient. The function of determining and correcting the presence or absence of a patient's gait based on the gait of the patient measured by the measuring device is determined by an application program stored in the portable terminal Lt; / RTI >

The control device is a portable terminal carried by the patient. The control device determines the gait state of the patient based on the plurality of pressure values transmitted from the transmission section, and determines whether or not the gait of the patient And if the gait state of the patient is abnormal as a result of the determination, determining a stimulus variable information for correcting the state and transmitting the determined stimulus variable information to the cerebellum stimulation apparatus is performed by an application program stored in the portable terminal .

In another embodiment, the control device may further include: a receiving unit that receives the pressure value transmitted from the transmitting unit; A database unit for storing abnormality determination information for determining whether or not a patient is walking with respect to a plurality of pressure values measured by the sensor unit and stimulus variable information for correcting a patient's gait according to the abnormality determination information; ; And determining whether there is an abnormality in the patient's gait based on the pressure value received at the receiving unit based on the abnormality determination information stored in the database unit, And a controller for transmitting stimulus variable information for correcting the gait of the patient based on the abnormality determination information based on the abnormality determination information to the cerebellum stimulation apparatus.

In this case, when the pressure value received from the receiving unit is identical to the abnormality determination information stored in the database unit, the control unit transmits stimulus variable information according to the abnormality determination information to the cerebellum stimulation apparatus, The presence or absence of the abnormality determination information is compared with the abnormality presence / absence determination information to determine whether or not the patient's gait is abnormal. If there is an abnormality in the determination result, The stimulus variable information according to the abnormality presence / absence information most similar to the pressure value can be transmitted to the cerebrum stimulating apparatus.

Meanwhile, the closed cerebral cerebral cerebral stimulation system according to an embodiment of the present invention includes an internal device that applies a stimulus to the brain of a patient to implant the cerebral cerebral stimulation device into the brain of a patient and correct the gait of the patient, And the external device is provided outside the brain of the patient so as to transmit the stimulation signal to be transmitted from the patient. The control device may include the external device or the function of the external device.

Meanwhile, when the closed cerebellar stimulation system according to an embodiment of the present invention is executed by an application program stored in a portable terminal carried by a patient, the application program may include a walking start button unit; A control unit for extracting gait state information of a patient including at least a left / right average, a stride and a pressure of the gait of the patient from the information about the pressure value received from the transmitter, and determining whether the gait of the patient is normal; A gait state display unit for displaying a patient's movement time, gait state information of the patient, and whether the gait of the patient is normal or not; An option button unit for changing a setting of the application program; And a termination button unit for terminating the application program.

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The closed-type cerebellar stimulation system according to the present invention is a system that monitors the activity of the brain such as measuring an electrical or chemical signal at an electrode implanted in the brain of a patient, and controls the degree of stimulation. And the degree of stimulation is adjusted so that the patient state can be accurately diagnosed and corrected in real time.

In addition, the closed-type cerebellar stimulation system according to the present invention directly measures the gait of a patient who has a symptom of gait disorder, such as a Parkinson's disease, and then, if there is an abnormality, a Deep Brain Stimulation (DBS) By providing proper stimulation, it is possible to accurately diagnose and correct the gait of a patient in real time.

In addition, the closed cerebral cerebral stimulation system according to the present invention allows a closed cerebellar stimulation system to be implemented using a portable terminal such as a smart phone carried by a patient, thereby making it easy to carry and configure, Storage function and the like can be maximized.

FIG. 1 is a block diagram of a closed-type cerebellum stimulation system according to an embodiment of the present invention,
2 is a flow chart illustrating a method for implementing a closed cerebellar stimulation system in accordance with an embodiment of the present invention,
3 is a block diagram illustrating a closed-type cerebellum stimulation system according to another embodiment of the present invention,
4 is a view schematically showing an embodiment in which a closed cerebellar stimulation system according to an embodiment of the present invention is provided,
5 is a view showing an embodiment in which a measurement sensor according to the present invention is provided,
6 to 9 are views for explaining one embodiment of a screen displayed on a portable terminal by an application program of the portable terminal according to an embodiment of the present invention.

Hereinafter, embodiments according to the present invention will be described in detail with reference to the accompanying drawings.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. Rather, the intention is not to limit the invention to the particular forms disclosed, but rather, the invention includes all modifications, equivalents and substitutions that are consistent with the spirit of the invention as defined by the claims.

The present invention relates to a method for diagnosing a patient who has a symptom of a gait disorder such as a Parkinson's disease in order to enable a more accurate diagnosis and correction by directly detecting the symptoms of the patient in the living and controlling the degree of stimulation, To a closed cerebral cerebral stimulation system capable of calibrating a patient's gait by providing a proper stimulus through a Deep Brain Stimulation (DBS) device when there is an abnormality in measurement, and a method of executing the same.

1 is a block diagram of a closed-type cerebellum stimulation system according to an embodiment of the present invention.

1, a closed cerebellar stimulation system according to an embodiment of the present invention includes Deep Brain Stimulation (DBS) apparatus that applies a stimulus for correcting a patient's gait to a brain of a patient, (10), a measuring device (20) for measuring the gait of the patient, and a controller for determining whether or not the patient is walking on the basis of the gait of the patient measured from the measuring device (20) And a controller (30) for transmitting stimulus variable information for correcting the gait of the brain stimulation device (10).

The cerebral and cerebral stimulation device 10 is an implantable device for applying electrical stimulation to a specific region of the brain to alleviate the symptoms of a disease such as Parkinson's disease. The stimulation device is implanted in the patient's brain to stimulate the patient's gait, An internal device 12 that applies to the brain, and an external device 14 that is provided outside the patient's brain to transmit a stimulation signal to be applied by the internal device 12.

Generally, the NFMIC (Near Field Magnetic Induction Communication) method is used for the transmission method between the internal device 12 and the external device 14 in the cerebellum stimulation device 10. In the NFMIC method, two coils are placed close to one coil (Amplitude Modulation), PM (Phase Modulation), and FM (Frequency Modulation), which are used in conventional RF communication, are used to communicate by using a phenomenon in which current flows by electromagnetic induction to the opposite coil when an alternating current is supplied. Can be applied. The NFMIC method has a disadvantage in that it can operate only at a short distance, but it has a merit of being relatively safe as compared with other communication methods and is mainly used as a communication method in the cerebral cerebral stimulation apparatus 10. [

The external device 14 may be separately provided from the control device 30 so that the stimulus parameter information transmitted from the control device 30 may be transmitted to the internal device 12 via the external device 14, The stimulus parameter information embedded in the control device 30 and substantially transmitted from the control device 30 may be directly transmitted to the internal device 12 or the control device 30 may be directly transmitted to the external device 140 ), And the present invention is not limited thereto.

Stimulus variable information is stimuli applied to the patient's brain by the internal device 12 to correct a patient's gait, and may include intensity of stimulation, frequency of stimulation, duration of stimulation, and the like.

The measuring device 20 includes a sensor part 22 composed of a plurality of pressure sensors for measuring a pressure value at a predetermined position of the foot in accordance with the patient's walking and a controller 30 for controlling the pressure value measured by the sensor part 22, The measuring device 20 may further include a power supply unit 26 for supplying power to the sensor unit 22 and the transmission unit 24.

The transmitting unit 24 may be provided to transmit data by wire or wirelessly, and preferably, a pressure value may be transmitted to the controller 30 by a Bluetooth method. Bluetooth (Bluetooth) is a technology that provides a low-power and low-cost wireless interface between a mobile phone and a peripheral device. It can not only transmit information through obstacles such as walls and bags, but also complies with Bluetooth standard in most countries. The same technology may be used in the present invention. It is preferable that the pressure value transmission method from the transmitting unit 24 to the controller 30 is performed by the Bluetooth method.

The controller 30 includes a receiver 32 for receiving the pressure value transmitted from the transmitter 24 of the measuring device 20 and a controller 32 for controlling the gait state of the patient based on the plurality of pressure values received by the receiver 32 And judges whether or not the patient is walking on the basis of the determined gait state of the patient. If the gait state of the patient is abnormal, the controller determines the stimulus variable information for calibrating the state, A controller 34 for transmitting the stimulus parameter information to the device 10, and a database unit 36 for storing the stimulus variable information according to the gait state of the patient having the abnormality.

The controller 30 may further include a transmitter 38 for transmitting stimulus variable information to the cerebral and cerebral stimulation apparatus 10. The controller 30 may be configured to transmit stimulus parameter information to the external device 14 of the cerebral and cerebral stimulation apparatus 10, The transmitting unit 38 may be provided in substantially the same form as the transmitting unit provided in the external device 14 of the conventional cerebral cerebral stimulation apparatus 10. [

The control unit 34 transmits the stimulus variable information stored in the database unit 36 to the cerebellum stimulation apparatus 10 when the gait state of the patient with the abnormality is stored in the database unit 36, The stimulus variable information according to the most similar state among the states stored in the database unit 36 can be transmitted to the cerebral and cerebral stimulation apparatus 10 when the patient's gait state is not stored in the database 36. [

The control unit 34 determines the gait state of the patient based on the plurality of received pressure values, and determines whether the gait of the patient is abnormal based on the determined state. For example, And determines whether each of the pressure values is a measured value at the foot of the patient. In particular, by judging whether each pressure value is a value measured at the left foot and the right foot and the change trend, And judges whether or not there is an abnormality in the state.

The control unit 34 continuously receives the pressure value received from the receiving unit 32 to determine the patient's gait state and determines whether the patient's gait correction based on the stimulus parameter information is corrected based on the patient's gait state And transmits a signal for stopping the operation of the cerebral and cerebral stimulation apparatus 10 to the cerebral and cerebral stimulation apparatus 10 when correction is made as a result of the determination, New stimulus variable information changed by the reference can be transmitted to the cerebellum stimulation apparatus 10.

If the patient's gait is corrected by the new stimulus variable information, the control unit 34 stores the new stimulus variable information in the database 36 as stimulus variable information for correcting the gait state of the patient having the abnormality .

The control unit 34 may also be configured to transmit a notification signal to a predetermined guardian or the primary caregiver if the patient's gait is not corrected for a predetermined period of time.

The control unit 30 may include a receiving unit 32 that receives the pressure value transmitted from the transmitting unit 24 of the measuring device 20 and a receiving unit 32 that receives the pressure value of the patient according to the plurality of pressure values measured by the sensor unit 22. [ A database unit 36 in which stimulus variable information for correcting the gait of the patient according to the abnormality determination information and the abnormality determination information for determining whether or not the gait is abnormal is stored is stored in the database unit 36, Based on the judgment information, judges whether or not there is an abnormality in the gait of the patient from the pressure value received by the receiving section 32. If there is an abnormality, And a controller 34 for transmitting stimulus variable information for calibrating the patient's gait according to the presence / absence determination information to the cerebral and cerebral stimulation apparatus 10.

In this case, when the pressure value received from the receiver 32 is the same as the abnormality determination information stored in the database unit 36, the control unit 34 supplies the stimulus variable information according to the abnormality determination information to the cerebellum stimulation apparatus 10 If it is not the same as the abnormality determination information stored in the database unit 36, the received pressure value is compared with the abnormality presence / absence determination information to determine whether the patient's gait is abnormal, If there is an abnormality as a result of the determination, stimulus variable information according to the abnormality presence / absence determination information most similar to the received pressure value may be transmitted to the cerebral and cerebral stimulation apparatus 10.

2 is a flow chart illustrating a method for implementing a closed cerebellar stimulation system in accordance with an embodiment of the present invention.

Referring to FIG. 2, a method of executing a closed-type cerebellum stimulation system according to an embodiment of the present invention includes steps S10 and S10 of measuring a pressure value at a predetermined position of a foot according to a patient's walking by a plurality of pressure sensors (S20) of determining whether the patient is walking based on the measured plurality of pressure values and determining whether the patient is walking or not, based on the determined state of the patient's walking; If there is an abnormality in the gait state, the stimulus variable information for correcting the gait state is determined from the database 36 and transmitted to the cerebellum stimulation apparatus 10 (S30) Determining whether the patient's gait state has been calibrated (S40); and if the calibrating state has not been determined based on the determined stimulus parameter information, (Step S50) of transmitting new stimulus variable information, which is obtained by modifying the excitation parameter information by a predetermined reference, to the cerebellum stimulation apparatus 10, and determining whether the gait state of the patient having the abnormality is corrected (S60). If it is determined that the new stimulus variable information is corrected, the new stimulus variable information is stored in the database as stimulus variable information for correcting the gait state of the patient having the abnormality (S70), and stopping the operation of the cerebral cerebral stimulation apparatus 10 (S80).

If it is determined that there is no abnormality in the gait state of the patient (S20), if the gait state of the patient is not abnormal, step (S10) of measuring the pressure value may be performed when the gait state of the patient is abnormal And then repeatedly executes it.

The step S30 of determining the stimulus parameter information and transmitting the determined stimulus parameter information to the cerebellum stimulation apparatus 10 includes the steps of determining whether the gait state of the patient having the abnormality is stored in the database unit 36, If the state is stored in the database unit 36, the stimulus variable information according to the state stored in the database unit 36 is transmitted to the cerebellum stimulation apparatus 10, and if it is not stored in the database 36 And transmitting the stimulus variable information according to the most similar state among the states stored in the database unit 36 to the cerebellum stimulation apparatus 10.

If it is determined in step S40 whether or not the patient's gait is calibrated, the operation of the cerebral and cerebral stimulation apparatus 10 is terminated in step S90 if calibration is performed based on the determined stimulus parameter information.

If it is determined in step S60 whether the gait state of the patient having the abnormality has been corrected by the new stimulus variable information in step S60 and the gait state of the patient having the abnormality has not been corrected by the new stimulus variable information (S50) of transmitting the new stimulus variable information to the cerebral and cerebral stimulation apparatus (10).

Further, in the method of executing the closed cerebral cerebral stimulation system according to an embodiment of the present invention, when the gait of the patient is not calibrated for a predetermined time, transmitting a notification signal to a predetermined guardian or a primary caregiver (S90 ). ≪ / RTI >

3 is a block diagram illustrating a closed cerebellar stimulation system according to another embodiment of the present invention.

Referring to FIG. 3, the closed type cerebral cerebral stimulation system according to the present embodiment uses a portable terminal 40 carried by a patient as a control device 30, and measures the gait of a patient measured by the measuring device 20 The function of judging and correcting the presence or absence of the gait of the patient on the basis can be executed by the application program 50 stored in the portable terminal.

The portable terminal 40 may include a receiving unit 42 that receives the pressure value transmitted from the transmitting unit 24 and a transmitting unit 44 that transmits stimulus parameter information to the cerebral and cerebral stimulation apparatus 10, The program 50 determines the gait state of the patient on the basis of the plurality of pressure values received by the receiving unit 42 and determines whether or not the gait of the patient is abnormal based on the determined gait state of the patient, A controller (52) for determining stimulus variable information for correcting the state when the patient's gait state is abnormal, and transmitting the determined stimulus variable information to the cerebellum stimulation apparatus (10); and a controller And a database unit 54 that is stored for each hook state.

That is, the application program 50 determines the gait state of the patient on the basis of the plurality of pressure values received from the transmitter 32 of the measuring apparatus 20, and, based on the gait state of the patient, If there is an abnormality in the gait state of the patient, the stimulus variable information for correcting the state is determined and transmitted to the cerebellum stimulation apparatus 10.

The receiving section 42 and the transmitting section 44 of the portable terminal 40 and the control section 52 and the database section 54 of the application program 50 have the same functions and functions as those in the above embodiment, The description is based on the detailed description in the above embodiments.

As described above, in the closed cerebral cerebral and cerebral stimulation system according to the embodiment of the present invention, the external device 14 of the cerebral and cerebral stimulation apparatus 10 may be provided in the control device 30, The present invention is also applicable to a case where the control device 30 is used as the portable terminal 40 carried by the patient and the execution thereof is executed by the application program 50 stored in the portable terminal 40. [ For example, the external device 14 may be provided in the portable terminal 40 so that the portable terminal 40 can be used as a patient-dedicated portable terminal, or a separate external device 14 may be provided in the portable terminal 40. [ (Not shown). The application program 50 may be stored in the portable terminal 40 or downloaded according to a user's selection.

Meanwhile, a method of executing a closed cerebellar stimulation system according to the present embodiment, that is, a method of executing a closed cerebellar stimulation system according to the present invention when executed by an application program stored in a portable terminal carried by a patient, A step of connecting the sensor unit 22 comprising a plurality of pressure sensors for measuring the gait of the patient to the mobile phone terminal 40, The method comprising the steps of: transmitting a plurality of pressure values measured by the pressure sensor to the mobile phone terminal; determining whether a patient is walking based on the plurality of pressure values transmitted by the application program, Judging whether or not a patient is walking on the basis of a state of the patient; The application program 50 determines the stimulus variable information for calibrating the stimulus variable information from the database unit 54, which stores the stimulus variable information for each of the patient's gait states, and transmits it to the cerebellum stimulation apparatus 10 , The application program 50 determines whether the gait state of the patient having the abnormality has been corrected by the determined stimulus variable information, and if the correction is not performed according to the determined stimulus variable information, The program 50 transmits new stimulus variable information that has changed the determined stimulus variable information by a predetermined reference to the cerebellum stimulation apparatus 10, and the application program 50 determines that the abnormality Judging whether or not the gait state of the patient is calibrated; The application program 50 transmits a signal for stopping the operation of the cerebral and cerebral stimulation apparatus 10 to the cerebral cerebral stimulation apparatus 10, And storing the stimulus parameter information in the database unit 54 as the stimulus variable information for correcting the gait state of the patient having the gait information.

FIG. 4 is a view schematically showing an embodiment of a closed type cerebral cerebral stimulation system according to an embodiment of the present invention.

4, the closed cerebral cerebral stimulation system according to the embodiment of the present invention includes an internal device 12 and an external device 14, and the internal device 12 includes a patient And the external device 14 may be provided outside the patient's brain, for example, in a pocket or the like.

The measuring device 20 may include a plurality of pressure sensors for measuring a pressure value at a predetermined position on the foot of the patient according to the user's walking. As shown in FIG. 4, It may be provided on both shoe of the patient so that the pressure value on both the left foot and the right foot can be measured. Also, when the measuring device 20 is provided in the shoe of the patient as described above, it may be provided in a state of being embedded in the bottom of the shoe during manufacture of the shoe, or may be provided in the insole of the shoe. The measuring device 20 may also be provided on the sock of the patient.

The control device 30 can be provided in a size that allows the patient to be portable. In this case, the patient can carry the control device 30 together with the external device 14 of the cerebral and cerebral stimulation device 10 in a pocket or the like. Further, as shown in the figure, the control device 30 may be a portable terminal carried by the patient. The external device 14 of the cerebral and cerebral stimulation apparatus 10 is built in or controlled by the control device 30 as described above, The apparatus 30 may be provided so as to be capable of executing the function of the external apparatus 14 by itself.

5 is a view showing an embodiment in which a measurement sensor according to the present invention is provided.

5, the measuring apparatus 20 according to the present invention includes a sensor unit 22 comprising a plurality of pressure sensors 21 for measuring a pressure value at a predetermined position of the foot in accordance with a patient's walking, A transmission unit 24 that transmits the pressure value measured by the pressure sensor 22 to the controller 30 and a power unit 26 that supplies power to the sensor unit 22 and the transmission unit 24.

As shown in FIG. 5, the pressure sensor 21 measures a pressure value at a predetermined position on the foot of a patient according to a patient's gait, detects a state of a patient's gait, And each of the pressure sensors 21 is preferably provided at a position where it is possible to accurately measure the patient's gait through the pressure value at that position and on both feet of the patient.

6 to 9 are views for explaining one embodiment of a screen displayed on a portable terminal by an application program of the portable terminal according to an embodiment of the present invention.

When the closed type cerebral cerebral stimulation system according to the embodiment of the present invention is executed by the application program 50 stored in the portable terminal 40 carried by the patient, the application program 50 includes a walking start button unit 51, and the information on the pressure value received from the transmitter 24 of the measuring device 20, and extracts the patient's walking state information including at least the left-right average, stride and pressure of the patient's gait, A gait state display section 53 in which the movement time of the patient, the gait state information of the patient, and whether the gait of the patient is normal or not is displayed on the gait state display section 53, An option button unit 55 for changing the setting of the application program 50 and a termination button unit 57 for terminating the application program 50. Data information stored in the database unit 56 is displayed It may comprise a database, button portion 58 of the lock.

Fig. 6 shows an embodiment of a menu window of an application program, Fig. 7 shows an embodiment of a screen displayed by the gait display unit 53, Fig. 8 shows a screen displayed when the database button unit 58 is pressed FIG. 9 shows an embodiment of a screen displayed when the select button unit 55 is pressed.

Hereinafter, one embodiment of the operation in which the closed cerebral cerebral stimulation system according to the present invention is executed will be described in detail.

First, a measuring device 20 composed of a battery 26, a Bluetooth module 24 and a pressure sensor 21 is disposed on the bottom of each shoe of a patient so that the value of the pressure sensor 21 measured every time the patient walks To be transmitted to the portable terminal 40 carried by the patient through the Bluetooth module 24.

The application program 50 installed in the portable terminal 40 organizes the information received from the pressure sensor 21 according to time and analyzes the patient's gait.

For example, unlike a normal person whose right and left legs are regularly crossed when walking, patients with Parkinson's disease are characterized by irregular movement of the two feet and losing weight, The time between the right foot and the right foot is greater than the time when the left foot is tilted. This means that the patient's gait is unbalanced and lopsided. In addition, since the weight loaded on both feet is different, a pressure applied to one side of the pressure sensor 21 for a long time is increased, and the time interval for suddenly shortening the time taken for the foot also means that the patient's stride is reduced .

However, since there is a case in which the time interval during which the foot is taken in spite of a normal gait, such as when the patient is running, may be greatly reduced. In this case, the option button portion 55 of the application program 50 The correction function can be blocked to prevent the error.

When the above-mentioned problems are detected in the application program 50, the application program 50 sets appropriate stimulus parameters (for example, stimulus intensity, stimulation frequency, duration of stimulation, etc.) ) From the database unit 56 in the application program 50. [0060] The database unit 56 stores information on the stimulation parameters that have been corrected in the past when there is a problem in the patient's walking state.

The application program 50 recognizing the problem in the patient's step finds a case in the database unit 56 that matches the current patient's situation and transmits the stimulus variable information for correcting the stimulus variable information to the external device of the cerebral and cerebral stimulation apparatus 10 via Bluetooth (14).

If there is no match in the database 56, the most similar situation is detected, and the stimulus parameters are changed by slightly changing the used stimulus parameters.

When the stimulus variable becomes effective, the stimulus is further stored in the database unit 56. If the stimulus variable is not effective, the stimulus is repeatedly changed by slightly changing the stimulus variable.

Even if such a feedback process is repeated, if a problem continues to occur in the gait of the patient, the notification message is transmitted to the doctor or the guardian registered in advance in the application program 50 to inform the patient of the situation.

The information stored in the database unit 56 of the application program 50 can be easily transmitted to a computer using Bluetooth so that the doctor in charge can understand the condition of the patient and help provide appropriate treatment to the patient You can give.

Hereinafter, another embodiment of the operation in which the closed cerebral cerebral stimulation system according to the present invention is executed will be described in detail.

First, the pressure sensor 21 is placed under the shoe of the patient to measure the gait of the patient. And transmits the sensed value of the pressure sensor 21 to the portable terminal 40 of the patient using the Bluetooth whenever the patient steps on the foot. The application program 50 installed in the portable terminal 40 collects data from the left foot and the right foot in chronological order. At this time, if it is determined that there is a problem in the gait of the patient, the database unit 56 in the program 50 calls up the stimulus variable information applied in the similar situation in the past and transmits this information again through the Bluetooth to the cerebellum stimulating apparatus 10 And sends it to the external device 14. This information is transmitted to the internal device 12 of the cerebral and cerebral stimulation apparatus 10 by a near field magnetic induction communication (NFMIC) method, and electric stimulation is applied to the patient according to this value, thereby correcting the gait of the patient.

The cerebral and cerebral stimulation apparatus 10 according to the present invention comprises an external device 14 existing outside a patient's body and an internal device 12 implanted in a patient's body. A wireless power transmission method may be used in which the battery power of the external device 14 is transferred to the internal device 12 using mutual induction between the external and internal coils.

The external device 14 may include a magnet and an external coil, and an external battery, a Bluetooth module, a microcontroller unit (MCU), and a near field magnetic induction communication (NFMIC) module. The magnet is used to align the outer coil and the inner coil with the patient's skin therebetween, and a magnet having an appropriate strength can be used depending on the thickness of the patient's skin. Coils are made by winding a wire made of copper in a circular shape, and apply an alternating current thereto to transmit not only the power to the opposite coil but also the power on / off of the internal device and information on the stimulation parameters.

The stimulus variable information transmitted from the portable terminal 40 of the patient is received through the Bluetooth module, processed again, and transmitted to the internal device 12 through the NFMIC module. This process is controlled by the MCU of the external device 14 and the NFMIC uses the modulation method such as Amplitude Modulation (AM), Phase Modulation (PM), and Frequency Modulation (FM) Can be delivered. The external battery can be removed and replaced with another battery if its life is over.

Hereinafter, another embodiment of the operation in which the closed cerebral cerebral stimulation system according to the present invention is executed will be described in detail.

First, when the application program 50 installed in the portable terminal 40 is executed, a menu window of the application program 50 as shown in FIG. 6 is displayed. When the user presses the walking start button 51 in the menu window, The pressure sensor 21 and the application program 50 are connected via Bluetooth.

From this time, the moving time of the patient is recorded and the information on the pressure time, the pressure intensity, etc. coming from the pressure sensor 21 of the shoe is processed to judge whether the patient's gait is in the right / left balance, .

7, there is a window 59 at the bottom of the screen displayed by the gait state display unit 53 for displaying whether the current patient's gait is entirely normal or abnormal, A window 60 for displaying whether the state of the connection signal between the Bluetooth device of the shoe and the portable terminal 40 is good is displayed.

8, when the user presses a database button 58 under the start button 51 in the menu window of the application program 50 as shown in FIG. 6, the information stored in the database 56 Are displayed on the screen. Here, information about the time at which the patient's gait was abnormal, the patient's gait state at that time, the stimulation parameters, and the stimulation parameters indicating the effect of the new correction may be displayed in detail.

The patient's walking state is represented by the degree of left-right coincidence showing how well the left and right footsteps are balanced, the time taken for one step to roughly know the stride, and the left and right pressure sensor values. The calibrated stimulus parameters are represented by information on the intensity of the electrical stimulus (intensity of the voltage or current), duration, frequency, and so on.

In addition, as shown in FIG. 8, a 'Database PC transfer' button 61 is displayed on the screen displayed when the database button unit 58 is pressed. If the portable terminal 40 and the computer are connected via Bluetooth The stored data can be transferred to the computer via the 'Transfer Database PC' button 61. [

6, an 'Option' button 55 is displayed under the 'database' button 58 in the menu window of the application program 50, and the user presses the 'Option' Various settings of the program 50 can be changed.

FIG. 9 shows an embodiment of a screen displayed when the option button unit 55 is pressed. As shown in FIG. 9, in the screen displayed when the 'Option' button 55 is depressed, You can turn on or off the ability to send notifications to your caregivers if you continue to have problems with your gait, or you can add or remove contacts from those who send you messages in the case of notifications.

In addition, the application program 50 basically determines whether the patient's walking state is normal or not based on the left-right balance, the stride, and the pressure, and can turn on or off the stimulation correcting function based on these three pieces of information. For example, when the patient runs while operating the stimulator, the time interval for sensing the pressure in the left and right pressure sensors is shortened, so that it can be determined that the patient program is abnormal in the application program 50. At this time, If the correction according to the stride is turned off, even if the pressure input period is short, this information is ignored, so that the erroneous correction of the erroneous correction can be prevented in advance.

9, the 'Database initialization' button 62 is displayed on the screen when the option button unit 55 is pressed. When the user presses the 'Database initialization' button 62, All information is deleted.

As described above, according to the present invention, in order to enable a more accurate diagnosis and correction by detecting the symptoms of the patient directly in the living and controlling the degree of stimulation thereof, symptoms such as a gait disorder such as a Parkinson's disease The present invention relates to a closed-type cerebral cerebral stimulation system capable of calibrating a patient's gait by appropriately stimulating the user by measuring a gait of a patient having an abnormality and using a Deep Brain Stimulation (DBS) , The embodiments may be modified in various forms. Accordingly, the present invention is not limited to the embodiments disclosed herein, and all changes which can be made by those skilled in the art are also within the scope of the present invention.

After the cerebellum stimulation system was first developed, various methods for precisely controlling the stimulation parameters were proposed. Typically, it is proposed to measure electric or chemical signals in an electrode implanted in a patient's brain or to light the patient's brain, and then to grasp the activity of the brain based on the shape of the reflected light to control the degree of stimulation. However, these methods have a lot of noises mixed in the acquired signal, so it is difficult to diagnose the accurate state and determine the proper intensity of the stimulation by the present technology. On the other hand, the closed-type cerebral cerebral stimulation system according to the present invention and the method of performing the same provide advantages of directly diagnosing the symptoms of the Parkinson's disease and correcting the stimulation, thereby enabling more accurate diagnosis and correction compared with the above- I have. The closed cerebellar stimulation system according to the present invention has an advantage of maximizing data processing, transmission, and storage functions because it uses a portable terminal of a patient such as a smart phone. Accordingly, the present invention can be utilized in a variety of healthcare-based implantable equipment fields among various medical equipment fields in which demand is rapidly increasing. In particular, if the pressure sensor is replaced with an acceleration sensor or another sensor for measuring a vital signal, and the cerebellum stimulating device is replaced with an implantable device such as a pacemaker, a variety of applications are possible.

10: cerebellum stimulation device 20: measuring device
21: pressure sensor 30: control device
40: portable terminal 50: application program

Claims (16)

CLAIMS What is claimed is: 1. A closed cerebral cerebral stimulation system for measuring and correcting a patient's foot having a symptom of a gait disorder,
Deep Brain Stimulation (DBS), which applies a stimulus to the patient's brain to correct the patient's gait by being implanted in the patient's brain;
A measuring device for measuring the gait of the patient; And
A control device for determining whether or not a patient is walking on the basis of the gait of the patient measured from the measuring device and for sending stimulus variable information for calibrating the patient's gait when there is an abnormality to the cerebellum stimulating device; A closed cerebellar stimulation system. The method according to claim 1,
Wherein the measuring device comprises a sensor part including a plurality of pressure sensors for measuring a pressure value at a predetermined position of the foot in accordance with a patient's walking, and a transmitter for transmitting the pressure value measured by the sensor part to the control device A closed cerebellar stimulation system. 3. The method of claim 2,
The control device includes:
A receiving unit for receiving a pressure value transmitted from the transmitting unit;
Determining whether the patient is walking based on the plurality of pressure values received by the receiving unit, determining whether the patient is walking on the basis of the determined gait state of the patient, Determining a stimulus variable information for correcting the state if the abnormality is present, and transmitting the determined stimulus variable information to the cerebellum stimulation apparatus; And
And a database unit in which the stimulus parameter information is stored for each gait state of the patient having the abnormality,
Wherein the control unit transmits stimulus variable information stored in the database unit to the cerebellum stimulation apparatus when the gait state of the patient having the abnormality is stored in the database unit, And transmits the stimulus variable information according to the most similar state among the states stored in the database unit to the cerebellum stimulation apparatus when the stimulus variable information is not stored in the database. The method of claim 3,
The control unit continuously receives the pressure value received from the receiving unit to determine the patient's gait state, determines whether the patient's gait is corrected based on the patient's gait state information, A signal for stopping the operation of the cerebellum stimulation apparatus is transmitted to the cerebrum cerebellum stimulation apparatus when the result correction is performed, and when the correction is not made, a new stimulus variable information Is transmitted to the cerebral cerebral stimulation apparatus. 5. The method of claim 4,
Wherein the controller stores the new stimulus variable information in the database as stimulus variable information for correcting the gait state of the patient having the abnormality when the patient's gait is corrected by the new stimulus variable information, A closed cerebellar stimulation system. 5. The method of claim 4,
Wherein the control unit transmits a notification signal to a predetermined guardian or a primary caregiver when the patient's gait is not corrected for a predetermined period of time. The method according to claim 1,
Wherein the control device is a portable terminal carried by the patient and the function of judging and correcting the presence or absence of the patient's gait based on the gait of the patient measured by the measuring device is executed by the application program stored in the portable terminal A closed cerebellar stimulation system. 3. The method of claim 2,
The control device is a portable terminal carried by a patient. The control device determines a gait state of the patient based on a plurality of pressure values transmitted from the transmission section, and determines whether or not the gait of the patient is abnormal based on the gait state of the patient And if the gait state of the patient is abnormal, determining the stimulus variable information for correcting the state and transmitting the determined stimulus variable information to the cerebellum stimulation apparatus is performed by the application program stored in the portable terminal A closed cerebellar stimulation system characterized by. 3. The method of claim 2,
The control device includes:
A receiving unit for receiving a pressure value transmitted from the transmitting unit;
A database unit for storing abnormality determination information for determining whether or not a patient is walking with respect to a plurality of pressure values measured by the sensor unit and stimulus variable information for correcting a patient's gait according to the abnormality determination information; ; And
Determining whether there is a gait of the patient based on the pressure value received by the receiving unit based on the abnormality determination information stored in the database unit, and if there is an abnormality, determining whether the abnormality is present among the stimulation parameter information stored in the database unit And a controller for transmitting stimulus variable information for calibrating a patient's gait according to the abnormal presence / absence determination information to the cerebellum stimulation apparatus. 10. The method of claim 9,
When the pressure value received from the receiving unit is equal to the abnormality determination information stored in the database unit, transmits the stimulus variable information according to the abnormality determination information to the cerebellum stimulation apparatus, And if it is not the same as the abnormality determination information, the received pressure value is compared with the abnormality determination information to determine whether the patient's gait is abnormal or not, And transmits the stimulus variable information according to the most similar abnormality determination information to the cerebellum stimulation apparatus. 11. The method according to any one of claims 1 to 10,
The cerebral and cerebral stimulation apparatus includes an internal device for implanting a stimulus for correcting a patient's gait into a brain of a patient and an external device provided outside the patient's brain to transmit a stimulation signal to be applied in the internal device Lt; / RTI &
Wherein the control device includes the external device or functions as the external device. 9. The method of claim 8,
The application program includes:
A walking start button portion;
A control unit for extracting gait state information of a patient including at least a left / right average, a stride and a pressure of a gait of the patient from the information on the pressure value received from the transmitter, and determining whether the gait of the patient is normal;
A gait state display unit for displaying a patient's movement time, gait state information of the patient, and whether the gait of the patient is normal or not;
An option button unit for changing a setting of the application program; And
And a termination button unit for terminating the application program. delete delete delete delete

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