CN106730337A - A kind of vagus nerve stimulator electronic prescription configuration system of quickly-chargeable - Google Patents
A kind of vagus nerve stimulator electronic prescription configuration system of quickly-chargeable Download PDFInfo
- Publication number
- CN106730337A CN106730337A CN201611194580.8A CN201611194580A CN106730337A CN 106730337 A CN106730337 A CN 106730337A CN 201611194580 A CN201611194580 A CN 201611194580A CN 106730337 A CN106730337 A CN 106730337A
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- China
- Prior art keywords
- vagus nerve
- nerve stimulator
- parameter
- sensor
- electronic prescription
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
Abstract
System is configured the invention discloses a kind of vagus nerve stimulator electronic prescription of quickly-chargeable is provided, the system includes vagus nerve stimulator and parameter acquisition equipment, the vagus nerve stimulator includes memory, electrode, impulse generator, processor, communication module, charge coil, main battery and reserve battery;The processor collects each physiological parameter of patient according to the parameter acquisition equipment, controls the electrode accordingly to be stimulated.The main battery is charged by charge coil and reserve battery, realizes the quick charge that vagus nerve stimulator electronic prescription configures system, alleviates the burden of patient, makes vagus nerve stimulator more intelligent, it is easier to control.
Description
Technical field
The present invention relates to implanted vagal stimulation system, in particular to a kind of vagus nerve thorn of quickly-chargeable
Swash the configuration system of system electronic prescription.
Background technology
Vagus nerve stimulator(VNS)It is a kind of to be planted for adjuvant therapy medicaments intractable epilepsy and the miniature of depression
Enter formula device, epilepsy syndromes can be obviously improved using Vagal nerve stimulation, but because vagus nerve stimulator is a plant
Enter class device, the mode that it is adjusted is needed to simplify and automated.
U.S. Patent application US20150119956A1 is disclosed carries out multi-modal stimulation using adjustable stimulation parameter combination
Treatment, but the therapeutic modality needs manual regulation to set stimulation parameter, and possible parameter setting is inaccurate when such as sleeping, it is impossible to examine
Feel.
Chinese patent application CN102641554A discloses the reaction type nerve electric stimulation with external sleep detection apparatus
System and method, the apparatus and method of the setting parameters of electrical stimulation are:Using judging patient whether in deep sleep
External sleep detection apparatus judge that patient is in deep sleep, and when being judged as YES, sending control signal makes pulse generation
Device weakens or stops output pulse signal automatically, so as to realize that reaction type automatically adjusts the output pulse signal of impulse generator,
The waste of power consumption is reduced, so as to extend the service life of stimulation system, financial burden is alleviated.
It can be seen that, at present, to the regulation of vagal stimulation electronic prescription also all in open loop approach, it is impossible to realize self adaptation
Closed ring set mode, setting vagal stimulation electronic prescription is automatically adjusted according to patient condition, but with automatically adjusting work(
The increase of energy, power consumption is also being doubled and redoubled, and how quickly to supplement implanted medical device electric energy as current technology problem.
The content of the invention
It is an object of the invention in overcoming the shortcomings of above-mentioned technology, there is provided a kind of vagal stimulation of quickly-chargeable
The configuration system of device electronic prescription, the system includes:Vagus nerve stimulator and parameter acquisition equipment, the vagal stimulation
Device includes memory, electrode, impulse generator, processor, communication module, charge coil, main battery and reserve battery, memory
The corresponding pulse generator parameters value of different patient's states is stored, pulse generator parameters includes the pulse frequency of boost pulse,
Pulse width, impulse amplitude and dutycycle etc., communication module get parms collecting device collection parameter, processor is according to parameter
The parameter of collecting device collection, current patents' state is judged according to the first preset algorithm, and corresponding pulse hair is determined from memory
Raw device parameter value, coordination electrode is accordingly stimulated;Processor controls charge coil to be charged to main battery and reserve battery;Treatment
Device control reserve battery also charges to main battery.The main battery and the reserve battery are Li-Ion rechargeable battery.The ginseng
Number collecting device includes acceleration transducer, myoelectric sensor, eeg sensor, EGC sensor, blood oxygen saturation collector
With one or more combination in eye potentiometric sensor;First sleep state can be according to acceleration transducer, myoelectric sensor and the heart
The combination of electric transducer measured value judges;Deep sleep state can be according to acceleration transducer, myoelectric sensor, EGC sensor,
The combination of eeg sensor and eye potentiometric sensor measured value judges;Motion state can be according to acceleration transducer, myoelectricity sensing
The combination of device and EGC sensor measured value judges.
Further, notifying parameters collecting device collection heart rate and blood oxygen saturation, processor according to collection heart rate with
Blood oxygen saturation and current patents' state, pulse generator parameters is adjusted according to the second preset algorithm.
Further, also including increasing external controller, controller may be selected Three models, and normal mode stops mould
Formula and special pattern, normal mode is according to the Automatic Optimal pulse generator parameters of embodiment 2, stop mode stop pulse generator
Stimulate, special pattern is stimulated for fixed pulse generator parameter value, do not optimized, prevent current environment lower sensor from surveying
Amount has deviation(Such as MRI environment)Cause the pulse generator parameters of adjustment inaccurate.
Brief description of the drawings
Fig. 1 is the configuration system diagram of the vagus nerve stimulator electronic prescription of the quickly-chargeable of this reality invention.
Description of reference numerals:
1. parameter acquisition unit;2. memory;3. processor;4. impulse generator;5. electrode;6. external controller.
Specific embodiment
The present invention is further described with reference to the accompanying drawings and examples.
First embodiment:
As shown in figure 1, a kind of configuration system of the vagal stimulation parameter electronic prescription of quickly-chargeable of the invention, including
Vagus nerve stimulator and parameter acquisition equipment 1.
Vagus nerve stimulator is used to stimulate the vagus nerve of patient P, so as to alleviate epilepsy syndromes, it includes depositing
Reservoir 2, communication module 3, impulse generator 4, processor and electrode 5, charge coil, main battery and reserve battery.
Memory 2 is used to store the corresponding predetermined pulse generator parameter of different conditions corresponding to patient P, pulse hair
Raw device parameter includes but is not limited to pulse frequency, pulse width, impulse amplitude and dutycycle etc..
Communication module 3 is used to carry out radio communication so as to obtain the people of the collection of parameter acquisition equipment 1 with parameter acquisition equipment 1
Body physiological parameter, communication module 3 is additionally operable to carry out radio communication with other equipment, and radio communication therein can be used this area public
Any technology known, such as RF or bluetooth etc..
Processor is used to be communicated with parameter acquisition equipment 1 by communication module 3, and notifying parameters collecting device 1 starts
Physiological parameter acquisition simultaneously obtains the human body physiological parameter that parameter acquisition equipment 1 is gathered, based on the human body physiological parameter, using shape
State detection algorithm carries out judgement and draws patient's states result to the current state of patient P, and corresponding state is called from memory 2
Predetermined pulse generator parameter.
Impulse generator 4 is used to generate corresponding electric stimulation pulse according to the control of processor.
Electrode 5 is to be wound in the vagal stimulation electrode at patient's P vagus nerves, and it passes through extension wire and is sent out with pulse
Raw device 4 is electrically connected, and the electric stimulation pulse that impulse generator 4 sends is applied to vagus nerve.
The processor 3 controls the charge coil to be charged to the main battery and the reserve battery;The processor 3
The reserve battery is controlled also to be charged to the main battery.The main battery and the reserve battery are Li-Ion rechargeable battery.
Parameter acquisition equipment 1 is used to gather one or more related physiological parameters of patient P, such as patient's movement or appearance
State, myoelectricity, brain electricity, electrocardio, blood oxygen saturation, eye electricity;Parameter acquisition equipment 1 be for measure the one of above-mentioned physiological parameter or
Multiple sensors, such as acceleration transducer, myoelectric sensor, eeg sensor, EGC sensor, blood oxygen saturation sensing
Device, eye potentiometric sensor, one or more sensors are configured in the portable set that suitable human body is worn.
Further, the current state of the patient P detected by processor includes sleep state, daily state and motion shape
State.
Further, acceleration transducer, myoelectric sensor, EGC sensor will be configured in parameter acquisition equipment 1, be located
Reason device receives body movement signal, electromyographic signal and the electrocardio of the patient P collected using parameter acquisition equipment 1 by communication module 3
Signal, processor is incited somebody to action using artificial neural network or SVMs according to above-mentioned body movement signal, electromyographic signal and electrocardiosignal
Patient's states are divided into sleep state MODE1, daily state MODE2And motion state MODE3。
Further, the sleep state in the current state of the patient P detected by processor also includes first sleep state
With deep sleep state.
Further, parameter acquisition equipment 1 also includes eeg sensor and eye potentiometric sensor, when processor is by patient
State demarcation is sleep state MODE1When, processor is further received by communication module 3 and gathered using parameter acquisition equipment 1
The EEG signals and electro-ocular signal of the patient P for arriving, with reference to the EEG signals and electro-ocular signal, processor is by the sleep state of patient
Further change and be divided into just sleep state MODE11With deep sleep state MODE12。
The work main-process stream of the configuration system of the vagal stimulation parameter electronic prescription is described as follows:
(1)Processor notifying parameters collecting device 1 carries out physiological parameter acquisition;
(2)Processor obtains the physiological parameter that parameter acquisition equipment 1 is gathered, and adoption status detection algorithm is current to patient P's
State is judged;
(3)According to the patient's states result that judgement draws, processor calls the predetermined pulse of corresponding state to occur from memory 2
Device parameter is simultaneously sent to impulse generator 4;
(4)Impulse generator 4 produces electric stimulation pulse and sends it to electrode 5 according to above-mentioned pulse generator parameters, electrode 5
Vagus nerve to patient carries out electro photoluminescence.
Second embodiment:
A kind of configuration system of vagal stimulation parameter electronic prescription, with keeping up with an embodiment identical vagal stimulation
Device and parameter acquisition equipment 1.
Processor is additionally operable to after judging to draw patient's states result, using parameters revision algorithm to being adjusted from memory 2
The predetermined pulse generator parameter of corresponding state is adjusted.
Further, parameter acquisition equipment 1 includes oximetry sensor, parameters revision algorithm be according to heart rate and
The measurement result of blood oxygen saturation is adjusted to the predetermined pulse generator parameter under corresponding state.
The workflow of the configuration system of the vagal stimulation parameter electronic prescription is by above-mentioned steps(3)Replace with
Lower step(3a):
(3a)Processor is adjusted using parameters revision algorithm to the predetermined pulse generator parameter under corresponding state, preferably
Ground, processor notifying parameters collecting device 1 collection heart rate and blood oxygen saturation, processor is using parameters revision algorithm according to heart rate
Measurement result with blood oxygen saturation is adjusted to the predetermined pulse generator parameter under current patents' state, and by after adjustment
Pulse generator parameters be sent to impulse generator 4.
3rd embodiment:
A kind of configuration system of vagal stimulation parameter electronic prescription, except with first or second embodiments identical fan
Walk outside nerve stimulator and parameter acquisition equipment 1, still further comprise external controller 6, the external controller 6 is used for patient
P is remotely controlled to vagus nerve stimulator in vitro.
The external controller 6 can have including the Three models including normal mode, stop mode and special pattern and by
Patient P carries out model selection control.
Normal mode is the default mode of the configuration system operation of the vagal stimulation parameter electronic prescription, as patient P
Controller 6 is not selected pattern or during from other pattern switchings to normal mode in vitro, according to above-mentioned steps(1)
(2)(3)(4)Or(1)(2)(3a)(4)Carry out automatically determining and optimizing for pulse generator parameters.
Stop mode is applied to patient P and substantially experiences the uncomfortable situation of electro photoluminescence, when on patient P in vitro controller 6
When have selected stop mode, processor control impulse generator 4 stops output electrical stimulation waveforms.
Special pattern is not easy to the particular surroundings of physiological parameter acquisition, such as MRI environment suitable for some, the particular surroundings
The measured deviation of physiological parameter sensors may be caused so as to cause the judged result mistake of current patents' state, when patient P exists
When have selected special pattern on external controller 6, the closed loop adjustment of pulse generator parameters is no longer carried out, i.e., no longer gather patient
The physiological parameter of P, the fixed pulse generator parameters of processor generation simultaneously controls the electric pulse that impulse generator 4 generates fixation to pierce
Swash.
Claims (5)
1. a kind of vagus nerve stimulator electronic prescription of quickly-chargeable configures system, including vagus nerve stimulator and parameter
Collecting device(1), it is characterised in that:The vagus nerve stimulator includes memory(2), electrode(5), impulse generator(4),
Processor(3), communication module, charge coil, main battery and reserve battery, the memory(2)Store different patient's states pair
The impulse generator answered(4)Parameter value, the pulse frequency of the pulse generator parameters value including boost pulse, pulse
Width, impulse amplitude and dutycycle, the communication module obtain the parameter acquisition equipment(1)The parameter of collection, the treatment
Device(3)According to the parameter acquisition equipment(1)The parameter of collection, current patents' state is judged according to the first preset algorithm, from institute
State memory(2)Determine the corresponding pulse generator parameters value, control the electrode(5)Accordingly stimulated;The place
Reason device(3)The charge coil is controlled to be charged to the main battery and the reserve battery;The processor(3)Control described standby
Also charged to the main battery with battery.
2. the vagus nerve stimulator electronic prescription of quickly-chargeable according to claim 1 configures system, and its feature exists
In:The parameter acquisition equipment(1)Including acceleration transducer, myoelectric sensor, eeg sensor, EGC sensor, blood oxygen
Multiple combination in saturation degree collector and eye potentiometric sensor;
First sleep state can be according to the group of the acceleration transducer, the myoelectric sensor and the EGC sensor measured value
Close and judge;
Deep sleep state can be according to the acceleration transducer, the myoelectric sensor, the EGC sensor, the brain fax
The combination of sensor and the eye potentiometric sensor measured value judges;
Motion state can be according to the combination of the acceleration transducer, the myoelectric sensor and the EGC sensor measured value
Judge.
3. the vagus nerve stimulator electronic prescription of quickly-chargeable according to claim 1 configures system, and its feature exists
In:Control the electrode(5)After accordingly being stimulated, the parameter acquisition equipment is notified(1)Collection heart rate and blood oxygen saturation,
The processor(3)Heart rate and blood oxygen saturation and current patents' state according to collection, adjust according to the second preset algorithm
The pulse generator parameters value.
4. the vagus nerve stimulator electronic prescription of quickly-chargeable according to claim 1 and 2 configures system, its feature
It is:The configuration system also includes external controller(6), the external controller(6)Three models, conventional mould may be selected
Formula, stop mode and special pattern, normal mode optimize the pulse generator parameters value using automated manner, and stop mode stops
Only impulse generator stimulates, and special pattern is stimulated for the fixation pulse generator parameters value.
5. the vagus nerve stimulator electronic prescription of quickly-chargeable according to claim 1 configures system, and its feature exists
In:The main battery and the reserve battery are Li-Ion rechargeable battery.
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CN201611194580.8A CN106730337A (en) | 2016-12-22 | 2016-12-22 | A kind of vagus nerve stimulator electronic prescription configuration system of quickly-chargeable |
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CN201611194580.8A CN106730337A (en) | 2016-12-22 | 2016-12-22 | A kind of vagus nerve stimulator electronic prescription configuration system of quickly-chargeable |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112473005A (en) * | 2020-11-17 | 2021-03-12 | 北京品驰医疗设备有限公司 | Implanted nerve stimulator |
CN113244533A (en) * | 2021-06-24 | 2021-08-13 | 景昱医疗器械(长沙)有限公司 | Parameter adjusting method and device, electronic equipment and computer readable storage medium |
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US20140277287A1 (en) * | 2009-10-08 | 2014-09-18 | Boston Scientific Neuromodulation Corporation | Efficient External Charger for an Implantable Medical Device Optimized for Fast Charging and Constrained by an Implant Power Dissipation Limit |
CN104225790A (en) * | 2014-09-19 | 2014-12-24 | 清华大学 | Closed loop nerve stimulation system |
CN105268103A (en) * | 2015-11-19 | 2016-01-27 | 北京品驰医疗设备有限公司 | In vitro charging implantation medical instrument |
CN105555359A (en) * | 2013-10-04 | 2016-05-04 | 波士顿科学神经调制公司 | Implantable medical device with a primary and rechargeable battery |
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Patent Citations (7)
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US20140277287A1 (en) * | 2009-10-08 | 2014-09-18 | Boston Scientific Neuromodulation Corporation | Efficient External Charger for an Implantable Medical Device Optimized for Fast Charging and Constrained by an Implant Power Dissipation Limit |
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