KR101412320B1 - Specimen containing unit, specimen measuring cassette, specimen measuring unit and specimen measuring device - Google Patents

Abstract

A specimen-containing unit according to one embodiment of the present invention is a structure that makes a specimen react with a reagent by immersing the specimen in the reagent. The specimen-containing unit may include a body unit which can rotate by external force; an extension unit which extends with a predetermined length from one side of the body unit in a longitudinal direction; and a specimen-containing unit which is formed on the end of the extension unit and has a containing hole which is penetrated while maintaining a predetermined angle to a predetermined length to immerse a specimen by capillary action.

Description

[0001] The present invention relates to a specimen containing unit, a specimen measuring cassette, a specimen measuring unit, and a specimen measuring apparatus.

The present invention relates to a specimen containing unit, a specimen measurement cassette, a specimen measurement unit and a specimen measurement apparatus, and more particularly to a specimen containing unit which can obtain accurate measurement results in measuring the result of a reaction between a specimen and a reagent, A measurement unit and a sample measurement apparatus.

BACKGROUND OF THE INVENTION [0002] In recent medical diagnostics or treatment areas through drugs, the measurement of concentrations of analytes to anesthetics or harmful chemicals has been usefully used in the medical or environmental field. Among them, the measurement of the biological sample concentration used in medical diagnostic and therapeutic fields continues to increase with the desire of human beings to be liberated from various diseases. Particularly, the glycosylated hemoglobin test, which can measure blood sugar in relation to diabetes, has an increasing interest because it can detect a relatively long-term average blood glucose level by one measurement.

Hemoglobin A1c (HbA1c), also referred to as glycated hemoglobin, is one of the hemoglobins contained in human Red Blood Cells. When blood sugar (glucose) in the blood rises, some of the glucose in the blood binds to the hemoglobin. Thus, the hemoglobin associated with glucose is called glycated hemoglobin. This glycated hemoglobin test can be used to estimate the mean value of blood glucose for the past 2 to 3 months. The glycated hemoglobin test has the advantage of being able to collect blood and examine it regardless of the meal time.

On the other hand, in the case of U.S. Patent No. 6,300,142, in order to measure an analyte present in a sample, a test sample is reacted with a first reactant through a first inlet and sequentially reacted with a second reactant through a second inlet, Is disclosed. In this case, measurements should occur sequentially at time intervals.

It is also necessary to intervene in the measurement step so that the measurer injects the test sample sequentially and reacts. Furthermore, since the beads combined with the glycated hemoglobin must be filtered once, the measurement is complicated and takes a long time.

In other words, these tasks require a multitude of direct interventions for the measurer, which can be cumbersome. In addition, the intervention of the measurer can complicate the measurement process and naturally slows the measurement time.

Korean Patent Registration No. 0798471 also discloses a method for producing a blood sample, which comprises a first receiving area for receiving a first reagent, a second receiving area for receiving a second reagent, a reaction area in which a blood sample reacts with the first reagent or the second reagent, A cassette comprising a measurement region for measuring the amount of total hemoglobin or glycated hemoglobin, the reaction region and the measurement region being formed to be divided according to the rotation angle position of the cassette.

However, in the case of the above-mentioned cassette, there is a problem that a part of the two reagents is mixed in the process of injecting the first reagent and the second reagent into the first receiving region and the second receiving region, respectively, The movement of the reagent due to the capillary phenomenon may occur along the fine gap between the top plate and the structure frame and may cause an error in the measurement result.

Further, when a cartridge including a blood sampling section configured to contain a blood sample injects a blood sample into the cassette, the amount of the blood sample to be collected is not constant, and further, when the sample exceeds the measurement limit, There is a problem that it can be brought. Therefore, it is urgent to study a device that can display more accurate measurement results.

An object of the present invention is to provide a specimen-containing unit, a specimen-measuring cassette, a specimen-measuring unit, and a specimen-analyzing unit, which can realize a reaction between a specimen and a reagent in a short period of time, prevent mixing of reagents and minimize the intervention of a specimen, And a sample measuring device.

A sample containing unit according to an embodiment of the present invention is a structure for allowing a specimen to react with a reagent while being immersed in a reagent, and includes: a body rotatable by an external force; An extension extending from the one surface of the body part along the longitudinal direction to a predetermined length; And a sample containing part provided at an end of the extended part and having a containing hole formed to penetrate the sample while maintaining a predetermined angle with the longitudinal direction so that the sample is contained by the capillary phenomenon.

The extension part of the specimen containing unit according to an embodiment of the present invention is disposed on the outer side with respect to the center of one surface of the body part, and when the specimen contained in the inclusion hole rotates by the rotation of the body part, The reagent can be agitated.

The lower end of the specimen containing part of the specimen containing unit according to an embodiment of the present invention may be formed so as to pass through a part of the cover of the receptacle containing the reagent and to immerse the specimen in the reagent.

The direction of the containing hole of the specimen containing unit according to the embodiment of the present invention may correspond to the tangential direction of the virtual circle formed by the end of the extending portion when the extension portion is rotated by the rotation of the body portion.

The extension of the specimen containing unit according to an embodiment of the present invention and the width of the specimen containing portion may be formed to correspond to each other.

The sample containing portion of the sample containing unit according to an embodiment of the present invention may be formed integrally with the extended portion.

A sample measurement unit according to another embodiment of the present invention includes a sample containing unit; Wherein the specimen containing portion includes a first accommodating portion in which the first reagent to which the specimen reacts is stored, a second accommodating portion which is partitioned from the first accommodating portion and in which the second reagent is stored, and the result of the reaction between the first reagent and the specimen And a measurement unit for measuring the measurement value of the sample.

The measurement unit of the specimen measurement unit according to another embodiment of the present invention may be configured to receive the specimen reacted with the first reagent in the first accommodation unit and to accommodate the second reagent after a predetermined time elapses have.

The introduction of the first reagent and the second reagent into the measurement portion of the sample measurement unit according to another embodiment of the present invention can be realized by the weight of the first reagent and the second reagent.

The first reagent and the second reagent of the sample measurement unit according to another embodiment of the present invention are respectively provided with a first foil tab and a second foil tab which seal the bottom of the first containing portion and the second containing portion And the first foil tab and the second foil tab are each provided with a sample measurement device for measuring the result of the reaction of the sample with the first reagent and the second reagent, The position of the first reagent and the second reagent may be changed from the bottom of the first receiving portion and the second receiving portion to allow the first reagent and the second reagent to flow into the measuring portion.

The first foil tab and the second foil tab of the specimen measurement unit according to another embodiment of the present invention may be folded so that the other end is directed toward one end.

The analyte measurement unit according to another embodiment of the present invention may further include an absorption unit which is located below the measurement unit and absorbs the mixture of the sample for which the result of the reaction between the sample and the first reagent is completed have.

The reaction of the specimen and the second reagent in the specimen measurement unit according to another embodiment of the present invention can be implemented in the measurement unit.

A sample measurement apparatus according to another embodiment of the present invention includes a sample measurement unit; Measuring the result of the specimen measurement cassette being mounted, reacting the specimen with the first reagent and the second reagent, and measuring the first foil tab and the second foil tab in the first and second receptacles, respectively, And an external force application unit for providing an external force such that the position is changed from the bottom surface of the part.

The external force applying unit of the specimen measuring apparatus according to another embodiment of the present invention may apply an external force directed to opposite ends to one end of the first foil tab and the second foil tab.

The external force applying unit of the specimen measuring apparatus according to another embodiment of the present invention may apply an external force to one end of the first foil tab and apply an external force to the other end of the second foil tab.

The first foil tab and the second foil tab of the sample measurement apparatus according to another embodiment of the present invention are respectively folded so that the other end is directed toward one end, 2 An external force can be applied by pulling or pushing the other end of the foil tab.

The specimen measuring body of the specimen measuring apparatus according to another embodiment of the present invention may include a rotational force applying unit for providing rotational force to rotate the body after the specimen containing unit is locked to the first reagent.

The sample containing unit, the sample measurement cassette, the sample measurement unit and the sample measurement apparatus according to the present invention can effectively realize the reaction between the sample and the reagent in a short time.

In addition, the place where the reagent is stored and the place where the reagent and the sample react with each other can be formed into a single structure, thereby providing convenience to the measurer.

In addition, it is possible to precisely measure the reaction result between a specimen and a reagent by preventing mixing between reagents.

In addition, the positional shift of the foil tab for introducing the reagent into the measurement part can be implemented in a simple manner.

1 is a schematic sectional view showing a specimen measuring apparatus according to the present invention.
FIGS. 2 to 5 are schematic sectional views for explaining a procedure of measuring a sample reaction result by a sample measurement apparatus according to the present invention. FIG.
6 is a schematic perspective view showing a specimen containing unit according to the present invention.
7 is a rear view for explaining the direction of the sample containing part provided in the sample containing unit according to the present invention.
8 is a schematic perspective view showing a modification of the specimen containing unit according to the present invention.
9 is a schematic perspective view showing a sample measurement unit according to the present invention.
10 is a schematic perspective view showing a modification of the sample measurement unit according to the present invention.
11 is a schematic sectional view showing a modification of the sample measurement unit according to the present invention.

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the drawings. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventive concept. Other embodiments falling within the scope of the inventive concept may readily be suggested, but are also considered to be within the scope of the present invention.

The same reference numerals are used to designate the same components in the same reference numerals in the drawings of the embodiments.

FIG. 1 is a schematic cross-sectional view showing a specimen measuring apparatus according to the present invention, and FIGS. 2 to 5 are schematic cross-sectional views for explaining a procedure for measuring a specimen reaction result by a specimen measuring apparatus according to the present invention.

1, a specimen measuring apparatus 10 according to the present invention includes a specimen containing unit 100 containing a specimen, a first reagent R1 which reacts with the specimen contained in the specimen containing unit 100, ) And the second reagent (R2), and the sample measurement cassette (200), and the result of the reaction between the sample and the first reagent (R1) and the second reagent (R2) And a sample measurement body 300 to be measured.

Here, the specimen containing unit 100 and the specimen measurement cassette 200 can constitute a specimen measurement unit 400, and the specimen measurement apparatus 10 is capable of constituting the specimen measurement cassette 200 And a sample measurement main body 300, as shown in FIG.

The specimen measuring device 10 is a device capable of sequentially measuring the reaction result of the specimen with the first reagent R1 and the reaction result of the specimen with the second reagent R2, Hereinafter, the measurement of glycated hemoglobin will be described as an example.

The specimen measuring device 10 which is a device for measuring glycated hemoglobin can measure the amount of glycated hemoglobin by a measurement method using light reflection characteristics. When measuring the amount of glycated hemoglobin of a blood sample as a specimen, The characteristics of hemoglobin, which specifically absorbs the signal, can be used, and the method of measurement is as follows.

First, referring to FIG. 2, a specimen containing unit 100 capable of containing a specimen in a containing hole 110 by capillary phenomenon is prepared, and then the specimen is contained in the containing hole 110.

The specimen contained in the containing hole 110 of the specimen containing unit 100 is passed through the cover call part 210 of the specimen measuring cassette 200 in which the first reagent R1 is stored, S1) to react with the first reagent (R1).

In this case, in order to improve the reaction rate of the first reagent (R1) and the specimen, the specimen containing unit (100) containing the specimen may be rotated, and the driving force for rotation may be transmitted to the specimen measuring cassette A sample measurement body 300 to which a sample is attached.

3, when the specimen measuring cassette 200 is mounted on the specimen measuring body 300, the specimen accommodating unit 100 is rotated by the rotational force applying unit 310 provided inside the specimen measuring body 300, Can be rotated within the first receiving portion S1.

The rotation force application unit 310 can be automatically lifted and lowered when the sample containing unit 100 is rotated so as to be rotated in the groove 122 formed in the body portion 120 of the sample containing unit 100 Can be inserted.

That is, the rotation of the specimen containing unit 100 by the rotational force applying unit 310 may be applied to the principle of a flat screwdriver or a phillips screwdriver.

However, the rotation of the specimen containing unit 100 by the rotational force application unit 310 is not limited to being implemented by the principle of the driver, and may be variously changed according to the intention of the person skilled in the art.

When the reaction between the first reagent R1 and the specimen is completed after a predetermined time by the rotation of the specimen containing unit 100, the reactant of the first reagent R1 and the specimen can be introduced into the measuring unit S3 .

4, the reactant of the first reagent R1 and the sample is introduced into the measuring unit S3 by the movement of the first foil tab 220 sealing the bottom of the first receiving unit S1 And the movement of the first foil tab 220 may be realized by an external force application unit 320 (indicated by an arrow) provided in the sample measurement body 300.

Here, the external force applying unit 320 can continuously move the first foil tab 110 in the other end direction by pushing one end of the first foil tab 220, S1 are opened.

When the bottom surface of the first receiving part S1 is opened, the reactant of the first reagent R1 and the sample flows into the measuring part S3, and a measurement sensor (not shown) provided in the sample measuring main body 300 ), The reaction result is measured using the light reflection characteristic.

Here, the measurement sensor outputs a light emission control signal to the light emitting element, converts the optical signal input from the light receiving element into an electric signal, and measures the reaction result.

When the measurement is completed, the mixture of the sample is absorbed by the absorption unit 230 located below the measurement unit S3, and then the second reagent R2 is introduced into the measurement unit S3.

5, the inflow of the second reagent R2 into the measuring portion S3 can be realized by the movement of the second foil tab 240 sealing the bottom of the second containing portion S2 And the movement of the second foil tab 240 can be realized by the external force application unit 320.

The external force application unit 320 can continuously pull the second foil tab 240 in the other end direction by pulling one end of the second foil tab 240, Is opened.

The mixture of specimens may be washed through the second reagent (R2) introduced into the measurement unit (S3) to measure the required reaction results.

Hereinafter, the specimen measurement unit 400 including the above-described specimen containing unit 100 and specimen measurement cassette 200 will be described in detail.

Fig. 6 is a schematic perspective view showing a specimen containing unit according to the present invention, and Fig. 7 is a rear view for explaining the direction of a specimen containing unit provided in the specimen containing unit according to the present invention.

6 and 7, the specimen containing unit 100 is a kind of structure that can contain a specimen as a blood sample, for example, so that the specimen can be locked to the reagent and react with the reagent.

Here, the reagent may be the first reagent R1 stored in the first receiving portion S1 of the sample measurement cassette 200 as described with reference to Figs.

Specifically, the specimen containing unit 100 includes a body portion 120 rotatable by an external force, an extension portion 130 formed by extending a predetermined length along a longitudinal direction from one surface of the body portion 120, And a sample containing part 140 provided at an end of the sample part 130 and having a containing hole 110 formed to penetrate the specimen by the capillary phenomenon.

The body portion 110 may have a substantially cylindrical shape and may have a groove 122 formed on the other surface thereof so that the rotational force applying portion 310 of the specimen measuring body 300 is inserted. The rotation of the part 120 can be applied to the principle of the driver.

The extension part 130 is a component that is rotatable in conjunction with the rotation of the body part 120 by the rotation force application part 310. The extension part 130 may be disposed on the outer side with respect to the center of one surface of the body part 120 have.

This is for stirring the specimen contained in the containing hole 110 and the first reagent R1 when the specimen containing part 140 is rotated by the rotation of the body part 120. [

In other words, the sample containing section 140 containing the sample is immersed in the first reagent R1 stored in the first storage section S1 of the sample measurement cassette 200, and the sample and the first reagent R1, the rotation of the body 120 is interlocked with the rotation of the body 120 to minimize the reaction time due to rotation.

Here, in order to maximize the efficiency of the reaction in the process of rotating the body-containing part 120 in conjunction with the rotation of the body part 120 while the first reagent Rl is locked, the direction of the containing hole 110 is the length Direction and a predetermined angle can be maintained.

Specifically, the direction of the containing hole 110 is formed by a virtual circle C formed by the end of the extension part 130 when the body part 120 is rotated by the rotation of the extension part 130 And the direction corresponding to the tangential direction (D), whereby the sample contained in the containing hole (110) can be efficiently introduced into the first reagent (R1).

As a result, the blood sample contained in the containing hole 110 of the sample containing section 140 is effectively hemolyzed by the first reagent R1 due to the direction of the containing hole 110 and the forming position of the extending section 130 You can escape.

The lower end of the specimen containing section 140 is inserted through the cover call section 210 covering the upper surface of the first accommodating section S1 of the specimen measuring cassette 200, The first reagent R1 may be sharply formed such that the sample is immersed.

Therefore, the specimen containing unit 100 according to an embodiment of the present invention can stably penetrate the first receiving portion S1 in which the first reagent R1 is stored while containing the specimen in the containing hole 110 .

However, the entire lower end of the specimen-containing portion 140 need not be formed sharply, and at least a part of the specimen-containing portion 140 may be sharply formed.

8 is a schematic perspective view showing a modification of the specimen containing unit according to the embodiment of the present invention.

Referring to FIG. 8, the specimen containing unit 100 'may have a width corresponding to the width of the extension 130' and the specimen containing unit 140 ', or may be integrally formed.

As a result, the extension 130 'and the sample containing portion 140' may be physically identical components, and the lower end of the sample containing portion 140 'may be sharply formed.

Fig. 9 is a schematic cutaway perspective view showing a sample measurement unit according to the present invention. Fig.

9, the sample measurement cassette 200 may constitute a sample measurement unit 400 together with the sample containing unit 100 described with reference to FIGS. 1 to 8, and may include a first storage unit S1, A second accommodating portion S2 and a measuring portion S3.

The first receiving part S1 can accommodate the first reagent R1 and the space in which the sample contained in the containing hole 110 of the sample containing part 140 reacts with the first reagent R1 .

That is, the first accommodating portion S1 penetrates the specimen accommodating portion 140 into the first accommodating portion S1 and rotates the specimen accommodating portion 140 by the rotative force providing portion 310, May mean the space in which the first reagent (R1) reacts.

However, the introduction of the sample into the first accommodating portion S1 is not limited to the one embodied by the sample containing portion 140, and may be implemented by various methods.

The first reagent R1 may be a blood sample for hemolysis of a blood sample that is a specimen, and a glycated hemoglobin binding material-bead that selectively reacts with a glycated hemoglobin.

The blood can be, for example, a buffer solution containing a surfactant such as N-2-Hydroxyethylpiperazine-N'-2-ethanesulfonic Acid HEPES (pH 8.1). Hemolyzed blood samples are accompanied by hemoglobin and glycated hemoglobin.

The glycated hemoglobin-binding substance is a substance capable of specifically binding to glycated hemoglobin. For example, at least one of boronic acid (BA), concanavalin A (Lectin), and antibody.

The bead may be a polymeric polysaccharide support such as agarose, cellulose or sepharose, polystyrene, polymethylmethacrylate, polyvinyltolune, and the like. At least one of latex beads and glass beads.

At this time, the size of the glycated hemoglobin binding material-bead size is preferably selected in consideration of the reaction time with the glycated hemoglobin-binding substance-bead precipitation time and the glycated hemoglobin bound to the glycated hemoglobin after the reaction.

In brief, the first reagent R1 may include blood for hemolysis of a blood sample that is a specimen, and a glycated hemoglobin binding material-bead that selectively reacts with glycated hemoglobin, and the blood, which is a specimen reacted with the first reagent (R1) It is preferable to measure the amount of total hemoglobin from the sample.

The second accommodating portion S2 may be partitioned from the first accommodating portion S1 and accommodate the second reagent R2.

The second reagent (R2) may include a washing solution capable of washing the mixture of the first reagent (R1) and a blood sample as a specimen.

Hemoglobin (Hb) present in the red blood cells of a blood sample as a specimen is mostly non-glycosylated hemoglobin (Ao). Only 4 to 14% of normal hemoglobin reacts with glucose to be present as glycated hemoglobin (HbA1c) .

Therefore, the glycated hemoglobin binding material-beads reacted with the blood sample through the first reagent R1 include glycated hemoglobin as well as general hemoglobin. Therefore, in order to measure the glycated hemoglobin in the blood, it is necessary to remove the normal hemoglobin.

For this, the second reagent (R2) preferably includes a washing solution capable of washing normal hemoglobin to enable measurement of glycated hemoglobin.

The measurement unit S3 may measure the result of the reaction between the first reagent R1 and the blood sample as the specimen and may measure the result of the reaction between the first accommodation unit S1 and the second accommodation unit S2 .

The measuring unit S3 may allow the mixture of the first reagent R1 and the blood sample, which is a specimen that is first introduced from the first containing unit S1, to flow into the blood sample and measure the total amount of hemoglobin in the blood sample , And the amount of hemoglobin can be measured using a light reflection characteristic by a measurement sensor (not shown) of the sample measurement body 300 on which the sample measurement cassette 200 is mounted.

Here, the measuring unit S3 may include an optical window that reflects light through an external optical sensor, which is a measurement sensor, and the cross section in the horizontal direction toward the lower side may be reduced.

Specifically, the measuring unit S3 may include a sloped surface 250 directed downward toward the center. The influx of the mixture of the first reagent R1 and the specimen into the measuring unit S3 may be adjusted by self weight Can be implemented.

As a result, the flow of the first reagent R1 into the measuring section S3 can be realized by the own weight of the first reagent R1.

Here, the outflow of the mixture of the first reagent (R1) and the specimen from the first receiving portion (S2) is performed by changing the position of the first foil tab (220) sealing the bottom of the first receiving portion And the positional change of the first foil tab 220 may be implemented by the external force application unit 320 of the sample measurement body 300.

On the other hand, after the total hemoglobin amount is measured for the mixture of the first reagent (R1) and the specimen introduced into the measurement unit (S3), the remaining solutions except for the binding material-bead bound to the hemoglobin and the glycated hemoglobin, And can be absorbed by the absorption portion 230 disposed below the measurement portion S3.

The absorber 230 may be, for example, an absorbent pad, but is not limited thereto.

After the remaining solution excluding the binding material-bead bound to the hemoglobin and the glycosylated hemoglobin is absorbed by the absorption part 230, the second reagent R2 is supplied from the second accommodation part S2 to the measurement part S3 And the second reagent R2 may be used to measure the amount of glycated hemoglobin by washing the blood sample mixture in the measuring unit S3.

Here, the outflow of the second reagent R2 from the second containing portion S2 to the measuring portion S3 is performed by the position of the second foil tab 240 sealing the bottom of the second containing portion S2 And the change of the position of the second foil tab 240 may be realized by the external force application unit 320 of the sample measurement body 300. [

On the other hand, the amount of the glycated hemoglobin is measured by a measurement sensor (not shown) of the sample measurement body 300, as in the case of measuring the amount of total hemoglobin from the blood sample mixture reacted with the first reagent Rl Can be measured.

Thereafter, the amount of hemoglobin can be divided by the amount of glycated hemoglobin to determine the relative amount of glycated hemoglobin in the blood sample as a sample (ratio of glycated hemoglobin (%) = glycated hemoglobin / total hemoglobin × 100).

Meanwhile, the reaction space between the sample and the first reagent (R1) and the second reagent (R2) may be different as described above. Specifically, the reaction space between the sample and the first reagent (R1) (S1), and the reaction space between the sample and the second reagent (R2) may be the measuring unit (S3).

The measuring unit S3 may be configured to receive the sample reacted with the first reagent R1 in the first receiving unit S1, that is, a mixture of the sample and the first reagent R1 The second reagent R2 may be received after a predetermined time elapses.

The change of the position of the first foil tab 220 and the second foil tab 240 sealing the bottoms of the first accommodating portion S1 and the second accommodating portion S2 may be performed by changing the position of the specimen measuring body 300, The external force application unit 310 may be implemented by an external force applying unit 310. [

In other words, the first reagent R1 and the second reagent R2 can be blocked from flowing out by the first foil tab 220 and the second foil tab 240, The first foil tab 220 and the second foil tab 240 are connected to the first receiving portion S1 and the second receiving portion S2 by the sample measurement main body 300 of the sample measurement apparatus 10 on which the measurement cassette 200 is mounted. The position of the second receptacle S2 from the bottom may be changed so that the first reagent R1 and the second reagent R2 may be introduced into the measurement unit S3.

Here, the external force applying unit 3200 provided in the specimen measuring body 300 may apply an external force to the opposite ends of the first and second foil tabs 220 and 240, Specifically, the external force application unit 320 may apply an external force to one end of the first foil tab 220 and provide an external force to the first end of the second foil tab 240.

However, the external force applying unit 320 may be formed to provide external force to the first foil tab 220 and the second foil tab 240. In this case, the first foil tab 220 And an external force which is pulled to one side of the second foil tab 240. [

Meanwhile, external force application by the external force application unit 320 may be implemented automatically or manually.

Fig. 10 is a schematic cutaway perspective view showing a modification of the sample measurement unit according to the present invention, and Fig. 11 is a schematic sectional view showing a modification of the sample measurement unit according to the present invention.

10 and 11, a first foil tab 220 'and a second foil tab 220' for sealing the bottom surfaces of the first receiving portion S1 and the second receiving portion S2 of the sample measurement cassette 200 ' The tab 240 'may be folded so that the other end is directed toward one end.

In this case, the external force application unit 320 provided in the sample measurement body 300 may be formed to provide an external force to the first foil tab 220 'and the second foil tab 240', respectively. The first and second foil tabs 220 'and 240' can be changed in position by providing an external force that pushes toward the lower side or an external force that pulls toward the upper side.

In summary, the present invention can realize a reaction between a specimen and a reagent in a short time by rotating the specimen containing unit 100, 100 'by the rotational force application unit 310 provided in the specimen measurement body 300 The place where the first reagent R1 and the second reagent R2 are stored and the place where the first reagent R1 and the second reagent R2 react with the sample are referred to as a specimen measurement cassette 200) so as to provide convenience to the user.

In addition, mixing of the first reagent R1 and the second reagent R2 is prevented, and the reaction result between the sample and the first reagent R1 and the second reagent R2 can be accurately measured.

The movement of the first foil tabs 220 and 220 'and the second foil tabs 240 and 240' for introducing the first reagent R1 and the second reagent R2 to the measuring unit S3 It can be simply implemented by the external force application unit 320, so that the configuration of the apparatus itself can be simplified.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be apparent to those skilled in the art that changes or modifications may fall within the scope of the appended claims.

10: specimen measuring apparatus 100: specimen containing unit
110: Containing ball 120: Body part
130: extension part 140: specimen containing part
200: sample measurement cassette 210: cover part
220: first foil tab 240: second foil tab
300: sample measurement body 400: sample measurement unit
S1: first accommodating portion S2: second accommodating portion
S3: measuring part R1: first reagent
R2: Second reagent

Claims (18)

A sample-containing unit for immersing a sample in a reagent and reacting with the reagent,
A body portion rotatable by an external force;
An extension extending from the one surface of the body part along the longitudinal direction to a predetermined length; And
And a sample containing portion provided at an end of the extended portion and having a containing hole penetratingly formed so as to contain the sample by the capillary phenomenon while maintaining a predetermined angle with the longitudinal direction.
The method according to claim 1,
Wherein the extension portion is disposed on the outer side with respect to the center of the one surface of the body portion so that the specimen contained in the containing hole is stirred with the reagent when the specimen containing portion is rotated by rotation of the body portion.
The method according to claim 1,
And the lower end of the specimen-containing portion penetrates a part of the lid of the receptacle containing the reagent, so that the specimen is sharply formed so as to be immersed in the reagent.
The method according to claim 1,
Wherein the direction of the containing hole corresponds to a tangential direction of an imaginary circle formed by the end of the extending portion when the extension portion is rotated by the rotation of the body portion.
The method according to claim 1,
And the width of the extended portion and the width of the sample containing portion are formed to correspond to each other.
The method according to claim 1,
And the specimen-containing portion is formed integrally with the extension portion.
A specimen containing unit according to any one of claims 1 to 6;
Wherein the specimen containing portion includes a first accommodating portion in which the first reagent to which the specimen reacts is stored, a second accommodating portion which is partitioned from the first accommodating portion and in which the second reagent is stored, and the result of the reaction between the first reagent and the specimen A sample measuring cassette including a sample measuring cassette for measuring the sample.
8. The method of claim 7,
Wherein the measuring unit accommodates the second reagent after a predetermined time after receiving the specimen reacted with the first reagent in the first accommodating portion.
8. The method of claim 7,
Wherein the influx of the first reagent and the second reagent into the measurement section is implemented by the weight of the first reagent and the second reagent.
8. The method of claim 7,
The first reagent and the second reagent are prevented from flowing out to the outside by the first foil tab and the second foil tab which seal the bottom of the first containing portion and the second containing portion,
Wherein the first foil tab and the second foil tab are formed by a sample measurement device for measuring a result of the sample reaction cassette being attached to the sample and reacting the sample with the first reagent and the second reagent, And the position of the second reagent is changed from the bottom of the second accommodating portion to allow the first reagent and the second reagent to flow into the measurement portion.
11. The method of claim 10,
And the first foil tab and the second foil tab are folded and the other end is disposed toward one end.
8. The method of claim 7,
And an absorber positioned below the measuring unit and absorbing the mixture of the sample for which the measurement of the result of the reaction between the sample and the first reagent is completed.
8. The method of claim 7,
Wherein the reaction of the specimen with the second reagent is implemented in the measurement unit.
A sample measurement unit according to claim 10;
Measuring the result of the specimen measurement cassette being mounted, reacting the specimen with the first reagent and the second reagent, and measuring the first foil tab and the second foil tab in the first and second receptacles, respectively, And an external force application unit for providing an external force such that the position is changed from the bottom surface of the part.
15. The method of claim 14,
And the external force applying unit applies an external force directed to opposite directions to one end of the first foil tab and the second foil tab.
16. The method of claim 15,
Wherein the external force application unit applies an external force to the one end of the first foil tab and applies an external force to the other end of the second foil tab.
15. The method of claim 14,
The first foil tab and the second foil tab are folded so that the other end is directed toward one end,
Wherein the external force applying unit applies an external force to pull out or push the other end of the first foil tab and the second foil tab.
15. The method of claim 14,
Wherein the specimen measurement body includes a rotational force applying unit for providing a rotational force to rotate the body after the specimen containing unit is locked to the first reagent.

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