KR101412120B1 - 살모넬라 혈청형의 분자적 동정을 위한 프라이머 및 이를 이용한 살모넬라 혈청형 동정 방법 - Google Patents

살모넬라 혈청형의 분자적 동정을 위한 프라이머 및 이를 이용한 살모넬라 혈청형 동정 방법 Download PDF

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KR101412120B1
KR101412120B1 KR1020110144486A KR20110144486A KR101412120B1 KR 101412120 B1 KR101412120 B1 KR 101412120B1 KR 1020110144486 A KR1020110144486 A KR 1020110144486A KR 20110144486 A KR20110144486 A KR 20110144486A KR 101412120 B1 KR101412120 B1 KR 101412120B1
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권혁준
김태은
김재홍
박미선
이덕용
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Abstract

본 발명은 RNA중합효소 베타 서브유닛 (rpoB) 유전자의 전체 염기서열을 이용하여 식중독의 주요 원인인 살모넬라의 혈청형을 동정하는 기술에 관한 것이다. 보다 구체적으로, 본 발명은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 분석하여 살모넬라 속 미생물의 혈청형을 동정하는 방법, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하기 위한 프라이머 및 염기서열을 결정하기 위한 프라이머, 상기 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물 및 키트, 그리고 주요 살모넬라 속 미생물의 혈청형에 특이적인 rpoB 폴리뉴클레오티드에 관한 것이다. 본 발명은 기존의 항혈청을 이용한 살모넬라 혈청형 동정법을 대체할 수 있는 분자 동정법으로 유용하게 사용될 수 있다.

Description

살모넬라 혈청형의 분자적 동정을 위한 프라이머 및 이를 이용한 살모넬라 혈청형 동정 방법 {Primers for molecular identification of Salmonella serotype and method for identifying Salmonella serotype using the same}
본 발명은 RNA중합효소 베타 서브유닛 (rpoB) 유전자의 전체 염기서열을 이용하여 식중독의 주요 원인인 살모넬라의 혈청형을 동정하는 기술에 관한 것이다. 보다 구체적으로, 본 발명은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 분석하여 살모넬라 속 미생물의 혈청형을 동정하는 방법, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하기 위한 프라이머 및 염기서열을 결정하기 위한 프라이머, 상기 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물 및 키트, 그리고 주요 살모넬라 속 미생물의 혈청형에 특이적인 rpoB 폴리뉴클레오티드에 관한 것이다. 본 발명은 기존의 항혈청을 이용한 살모넬라 혈청형 동정법을 대체할 수 있는 분자 동정법으로 유용하게 사용될 수 있다.
살모넬라는 국내외에서 가장 빈발하는 식중독 원인균 중 하나로, 최근 단체급식의 증가로 인해 건당 환자수가 증가하면서, 공중보건학적으로 중요한 병원체로 인식되고 있다. 살모넬라 속 균은 DNA-DNA 교잡법에 의해 단일한 군을 이루고 있으며, 대장균과는 99%의 상동성을 보이며, 현재 세계보건기구 (WHO) 협력 센터의 제안에 따라 두 개의 종 (species) [Salmonella enterica와 Salmonella bongori (V)] 및 여섯 개의 아종 (subspecies) [Salmonella enterica subsp. enterica (I), Salmonella enterica subsp. salamae (II), Salmonella enterica subsp. arizonae (IIIa), Salmonella enterica subsp. diarizonae (IIIb), Salmonella enterica subsp. houtenae (IV), Salmonella enterica subsp. indica (VI)] 으로 분류되고 있다.
살모넬라의 혈청형은 현재까지 균체항원 (Somatic antigen; O)과 편모항원 (Phase I, II flagellin; H)에 기초한 Kaufmann-White 분류법에 의해 O 혈청형 46개와 H 혈청형 114개가 확인되었고, 총 2,523개의 다양한 혈청형이 동정되었다. 살모넬라 혈청형의 동정은 역학 연구에 있어 가장 기본이 되는데, 전통적인 혈청학적 방법을 적용하기 위해서는 혈청형 동정을 위한 모든 혈청을 확보하고 있어야 하며 새로운 혈청형이 출현하는 경우 그에 대한 항혈청을 확보해야 하므로, 소수의 공인된 실험실에서만 동정이 이루어지며 발현되는 표현형에 따라 결과가 다르게 나타날 수 있다 (Andrews WH, et al., 1992, Salmonella, in FDA Bacterilogical Analytical Manual ed. Tomlinson, L. pp.51-69. Arlington, VA :AOAC International.; Desmonts C., et al., 1990, Appl Environ Microbiol 56:1448-1452.). 또한, 동정이 안 되는 분리주의 경우 파스퇴르 연구소에 의뢰하여 혈청형을 동정해야 하는 번거로움이 있다.
이에, 기존의 항혈청에 의한 동정법을 대체할 수 있는 살모넬라 혈청형 동정법을 개발하기 위한 다양한 연구가 이루어지고 있다. 일 예로, LPS (Lipopolysaccharide)에 대한 ELISA 검출법이 소개되었으며 (Rigby CE. 1984. Appl Environ Microbiol 47:1327-1330), 여러 가지 O 항원에 대한 단클론항체를 이용한 동정법도 소개되었으나 (Araj GF, et al., 1987, J Clin Microbiol 25: 2150-2153; Lee HA, et al., 1990, Appl Envirom Microbiol 56: 1541-1546.; Torensma R, et al., 1992. Appl Envirom Mcirobiol 58:3868-3872.), 다수의 단클론항체가 요구되며 교차반응이 나타나는 경우도 있어 기존의 혈청형 검사법 대비 차별성이 없는 문제가 있다.
최근에는 분자생물학적 기술의 발달로, 생화학적 성상에 기초한 기존의 분류법 외에도 유전자 염기서열에 기초한 분자 분류법이 대두되고 있는데, 대표적으로 세균부터 동식물의 세포까지 모두 존재하는 리보솜 RNA (rRNA)가 연대기적 분자 표지로써 널리 사용되고 있으며, 16S/18S rDNA (ribosomal DNA)의 염기서열 분석 작업이 미시간 대학의 리보솜 데이터베이스 계획 (RDP II)을 통해 이루어지고 있다. 현재 20,000 종의 16S/18S rDNA 염기서열이 확보되어 생물의 분류 및 진화 연구에 중요한 자료가 되고 있으나, 기존의 혈청형 동정법에 비해 구분 능력이 떨어진다는 한계가 지적되고 있다.
16S/18S rDNA 외에도 다양한 분자 표지들이 살모넬라 혈청형 동정을 위해 제안되었다. 일 예로, fliC (H1-항원) 및 fljB (H2-항원) 유전자를 PCR로 증폭하여 각각 HhaI및 HphI 제한효소로 절단한 후 그 분획을 분석하는 PCR-RFLP (restriction fragment length polymorphism)법이 보고되었으나, fliC는 195개의 혈청형이 74개의 제한형 (restriction pattern; 38%)으로 분류되고, fljB는 134개 혈청형이 47개의 유전형 (35%)으로 분류되어 분별능력이 낮았고, 표준형 Typhi와 변이형 Typhi가 다른 유전형으로 분류되고 Salmonella Dublin과 Salmonella Enteritidis는 구분이 되지 않았다 (Dauga 등., 1998, JCM. 2835-2843). 다른 분자 표지의 예로, atpD (ATP 합성 효소 베타소단위유전자)가 Salmonella Typhimurium과 Salmonella Dublin 사이의 상동성이 99.2%로 비교적 높은 것으로 보고되었다 (Christensen & Olsen, 1998, FEMS Microbiol Lett. 161:89-96).
또한, 자동 리보타이핑 시스템 (automated ribotyping system: RiboPrinter)이 소개되었으나, 117개 분리주 중 34주 (29%)는 혈청형 수준에서, 11주 (9%)는 균주 수준에서, 46주 (39%)는 종 수준에서 동정되었고, 나머지 26주 (22%)는 동정되지 않았다 (Oscar, 1998. J Food Prot. 61:519-524).
또한, 16S-23S rRNA spacer RFLP 법에 의할 경우 58개 혈청형 101주에 대해 10개 (17%) 혈청형만이 특이적인 유전형을 보이고 나머지는 구분이 안 되었다 (Christensen 등., 2000, J Appl Microbiol. 89:130-136). 또한, tyv, wzx multiplex PCR을 이용하여 10종의 프라이머를 32개 혈청형 69주에 대해 적용한 결과 혈청형 특이적인 반응을 얻었으며, 선행 연구에 사용한 multiplex 방법과 같이 사용 시 84.9% (423/500주)의 정확성을 보였다는 보고가 있었다 (Silvia Herrera-Leon 등., 2007, Res. Microb., 122-127). 또한, Salmonella enterica 균주 간 염기서열의 차이를 보이는 하우스키핑 유전자 및 혈청 특이적인 병원성 유전자 (virulence gene)의 검출 (panB , fimA , aceK , mdh , icdA , manB , and spaN)을 통해 25균주로부터 8가지 MLST (multilocus sequence typing) 타입을 얻어내었고 이것은 혈청형과 연관성이 있는 것으로 보고되었다 (Sharinne Sukhnanand등., 2005, JCM. 3688-3698).
또한, 33가지 혈청형에 대해 hin 유전자 PCR 법을 사용하여 단상 편모 살모넬라를 동정하는 방법이 보고되었으나, 단상 편모/이상 편모 살모넬라 간의 구분만 가능할 뿐, 같은 그룹 내의 살모넬라 혈청형들 간에는 구분 안 되었다 (김성훈 등., 2005, J. of Bac. and Virol. 4:291-297). 또한, Allele specific rfb의 allele specific PCR에 의할 경우 살모넬라 serogroup D내 Salmonella gallinarum과 Salmonella pullorum의 분류가 가능하였으나, Salmonella Pullorum과 Salmonella Enteritidis 및 Salmonella Dublin, Salmonella Typhi 등 Salmonella serogroup D내의 다른 혈청형 간에는 구분이 안 되었다 (Devendra 등. J. Microbial Methods. 60:169-177, 2005).
또한, 혈청형 분류의 정확도를 높이기 위해 Salmonella Enteritidis와 Salmonella Derby를 구분하는 프라이머 세트 및 Salmonella Saint Paul와 Salmonella Anatum, Salmonella Branderup, Salmonella Ohio를 구분하는 프라이머 세트를 추가시킨 경우 혈청학적 방법을 기준으로 할 때 97% 정확성을 보였으나, 실험에 사용한 1,024가지 조합의 amplicon codes로 알려져 있는 1,478개 혈청형 모두를 구분하지는 못하였다.
따라서, 보다 많은 실험실에서 수행할 수 있고, 결과가 객관적이고 명확하며, 모든 살모넬라의 혈청형을 동정할 수 있는 기술이 요구되고 있다.
한편, RNA 중합효소 베타 서브유닛 (RNA polymerase beta subunit)을 코딩하는 rpoB 유전자가 모든 생물에 보존되어 있음이 알려지면서, rpoB 유전자 내 리팜피신 내성을 유발하는 분절(rif)을 표적으로 하는 PCR 을 사용하여 다양한 병원균들의 동정과 분류하는 기술이 개발되었다. 예를 들어, Mycobacterium (Kim 등, J Clin Microbiol 37:1714-1720, 1999), Borrelia (Lee 등, J Clin Microbiol 38:2557-2562, 2000), Bartonlla (Renesto 등, Research in Microbiology 151:831-836, 2000), Bacteroides (Ko, Kuwahara 등, Clin Microbiol Infect 13:48-54, 2007), 및 Legionella (Ko 등, J Clin Microbiol 40:2653-2658, 2002) 속 미생물의 분류와 동정에 rpoB 유전자가 사용된 바 있다. 상기 rpoB 유전자를 이용한 동정법의 경우 대부분 고변이 부분을 포함하는 부분 염기서열을 사용하였다.
살모넬라 혈청형 동정에 있어서도 rpoB 유전자의 부분 염기서열을 사용한 시도가 있었으나, 이는 Salmonella enterica subsp. enteric 의 계통분석을 위하여 rpoB 유전자 중 고변이 부위를 포함하는 부분 염기서열(612-937)을 사용한 것으로, 살모넬라의 일부 아종에 대해서만 동정이 가능한 한계가 있다 (Kwon 등, Veterinary Microbiology, 2001, 82: 121- 129). 이와 같이, 지금까지 살모넬라 혈청형 동정에 특이적인 유전자는 전무하고, rpoB 의 부분 염기서열을 사용한 살모넬라 혈청형 동정의 가능성이 제시되었으나 부분 서열을 사용하여 구분 능력이 상대적으로 낮아 적용성이 낮은 문제가 있다.
이에, 본 발명자들은 모든 살모넬라 혈청형의 rpoB 유전자 전체를 증폭할 수 있는 프라이머 및 상기 전체 유전자 염기서열을 결정할 수 있는 프라이머를 설계하였으며, 이 프라이머들을 사용하여 전 세계적으로 빈발하는 살모넬라 혈청형들에 특이적인 rpoB 유전자의 전체 염기서열을 분석하여 데이터베이스를 구축하였다. 또한, 식중독 환자나 주변 환경으로부터 살모넬라로 의심되는 미지의 균(목적 균주)이 분리되었을 때, 상기 프라이머를 사용하여 목적 균주의 rpoB 유전자의 전체 염기서열을 증폭 및 결정하고, 이를 이미 확보된 데이터베이스 상의 살모넬라 혈청형들의 rpoB 유전자의 염기서열과 비교함으로써, 목적 균주의 혈청형을 정확하게 판단할 수 있음을 확인하였다. 또한, 상기 rpoB 유전자의 전체 염기서열을 이용한 살모넬라 혈청형 동정법이 모든 살모넬라 균주에 광범위하게 적용될 수 있으며 보다 신속하고 정확한 판단에 유용하게 사용될 수 있음을 확인하여, 기존의 항혈청을 이용한 살모넬라 혈청형 동정법을 대체할 수 있는 분자적 동정법으로서 본 발명을 완성하였다.
본 발명은 RNA중합효소 베타 서브유닛 (rpoB) 유전자의 전체 염기서열을 이용하여 살모넬라의 혈청형을 동정하는 기술을 제공한다. 또한, 본 발명은 살모넬라 혈청형의 전체 rpoB 유전자를 증폭 및 결정할 수 있는 프라이머, 그리고 상기 프라이머를 사용하여 확인된 주요 살모넬라 혈청형 균주들의 rpoB 폴리뉴클레오티드 및 이의 염기서열 정보를 이용하여 효과적으로 살모넬라의 혈청형을 동정하는 기술을 제공한다.
보다 구체적으로, 본 발명의 하나의 목적은 rpoB 유전자의 전체 염기서열을 증폭하는 단계를 포함하는 살모넬라 속 미생물의 혈청형을 동정하는 방법을 제공하는 것이다.
본 발명의 또 하나의 목적은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하기 위한 프라이머를 제공하는 것이다.
본 발명의 또 하나의 목적은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 결정하기 위한 프라이머를 제공하는 것이다.
본 발명의 또 하나의 목적은 상기 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공하는 것이다.
본 발명의 또 하나의 목적은 상기 조성물을 포함하는 살모넬라 속 미생물의 혈청형 동정용 키트를 제공하는 것이다.
본 발명의 또 하나의 목적은 상기 프라이머를 사용하여 확인된, 주요 살모넬라 속 미생물의 혈청형들에 특이적인 rpoB 폴리뉴클레오티드를 제공하는 것이다.
본 발명의 또 하나의 목적은 주요 살모넬라 속 미생물의 혈청형들에 특이적인 rpoB 폴리뉴클레오티드를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공하는 것이다.
상기 목적을 달성하기 위한 하나의 양태로서, 본 발명은 RNA 중합효소 베타 서브유닛 (rpoB) 유전자의 전체 염기서열을 증폭하는 단계를 포함하는 살모넬라 속 미생물의 혈청형을 동정하는 방법에 관한 것이다.
이를 위한 바람직한 양태로서, 본 발명은
(1) 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하는 단계;
(2) 상기 증폭된 rpoB 유전자의 전체 염기서열을 결정하는 단계;
(3) 상기 단계 (2)에서 얻어진 염기서열을 표준 균주의 rpoB 유전자의 염기서열과 비교하여 혈청형을 결정하는 단계를 포함하는,
살모넬라 속 미생물의 혈청형을 동정하는 방법에 관한 것이다.
바람직하게, 상기 단계 (1) 및 단계 (2) 는 살모넬라 속 미생물의 rpoB 유전자의 염기서열(서열번호 15) 중에서 표 1에 기재된 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머를 사용하여 수행하는 것일 수 있다.
보존부분의 염기 위치
1-139 1174-1202 2275-2306 3151-3206
146-251 1291-1367 2404-2447 3223-3260
268-341 1403-1472 2470-2522 3283-3326
343-380 1501-1559 2536-2558 3331-3362
394-422 1561-1583 2581-2616 3385-3416
460-491 1621-1652 2641-2660 3424-3443
493-524 1681-1709 2683-2718 3457-3486
526-587 1729-1754 2720-2749 3488-3506
628-647 1756-1796 2751-2783 3562-3608
685-707 1798-1844 2785-2835 3646-3756
709-739 1849-1895 2837-2889 3790-3821
751-770 1906-1940 2902-2933 3833-3854
799-818 1966-2006 2945-2984 3865-3896
842-878 2047-2066 2986-3028 3907-3926
919-971 2089-2186 3035-3059 3928-3947
994-1061 2188-2231 3088-3111 3949-3986
1079-1100 2239-2261 3113-3149 3988-4019
1102-1130
또한 바람직하게, 상기 단계 (1) 은 서열번호 1 및 2, 또는 서열번호 3 및 4의 염기서열을 가지는 프라이머 쌍을 사용하여 rpoB 유전자의 전체 염기서열을 증폭하는 것일 수 있다.
또한 바람직하게, 상기 단계 (2) 는 서열번호 5 내지 서열번호 14의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 1종 이상의 프라이머를 사용하여 rpoB 유전자의 전체 염기서열을 결정하는 것일 수 있다.
또한 바람직하게, 상기 단계 (3) 에서 표준 균주의 rpoB 유전자의 염기서열은 서열번호 15 내지 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 것일 수 있다.
또 하나의 양태로서, 본 발명은 살모넬라 속 미생물의 rpoB 유전자의 염기서열 (서열번호 15) 중에서 표 1에 기재된 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머에 관한 것이다.
또 하나의 양태로서, 본 발명은 서열번호 1 및 2, 또는 서열번호 3 및 4의 염기서열을 가지는, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 증폭용 프라이머에 관한 것이다.
또 하나의 양태로서, 본 발명은 서열번호 5 내지 서열번호 14의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 결정용 프라이머에 관한 것이다.
또 하나의 양태로서, 본 발명은 상기 프라이머들 중 어느 하나 이상을 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물에 관한 것이다.
또 하나의 양태로서, 본 발명은 상기 살모넬라 속 미생물의 혈청형 동정용 조성물을 포함하는 키트에 관한 것이다.
또 하나의 양태로서, 본 발명은 서열번호 15 내지 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 살모넬라 속 미생물의 rpoB 폴리뉴클레오티드를 포함하는, 살모넬라 속 미생물의 혈청형 동정용 조성물 에 관한 것이다.
또 하나의 양태로서, 본 발명은 서열번호 15, 서열번호 16, 서열번호 17, 서열번호 19, 서열번호 20, 서열번호 21, 서열번호 22, 서열번호 24, 서열번호 25, 서열번호 26, 서열번호 28, 서열번호 31, 서열번호 32, 서열번호 33, 서열번호 34, 서열번호 38, 서열번호 43, 서열번호 44, 서열번호 45, 서열번호 47, 서열번호 49, 서열번호 50, 서열번호 51, 서열번호 54, 서열번호 55, 서열번호 56, 서열번호 57, 서열번호 59, 서열번호 60, 서열번호 61, 서열번호 63, 서열번호 64, 서열번호 65, 서열번호 66, 서열번호 67, 서열번호 68, 서열번호 70, 서열번호 74 및 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 살모넬라 속 미생물의 rpoB 폴리뉴클레오티드에 관한 것이다.
이하, 본 발명을 보다 상세하게 설명한다.
본 발명자들은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 분석하여 살모넬라 속 미생물의 혈청형을 동정하는 방법을 확립하기 위하여, GenBank에 등록된 살모넬라 혈청형 균주 44 주의 rpoB 게놈 서열을 다중배열하여 혈청형 간 차이를 보이는 rpoB 유전자의 변이 부분과 프라이머 설계에 유용하게 사용할 수 있는 보존된 부분을 확인하였고, 이를 토대로 rpoB 전체를 증폭할 수 있는 프라이머 2개쌍을 설계하였고, 염기서열 결정을 위한 프라이머를 보존된 부분에서 설계하였다. 또한, 이 프라이머들을 이용하여 질병관리본부 국립보건원 장내세균팀으로부터 제공받은 살모넬라 균주들의 rpoB 유전자의 전체 염기서열을 분석하여 데이터베이스를 구축하였다. 또한, 동정하고자 하는 목적 균주의 rpoB 전체 염기서열을 증폭 및 결정하고 상기 데이터베이스의 염기서열과 비교 분석함으로써 살모넬라 혈청형을 동정하는 새로운 방법을 개발하게 되었다.
어떤 유전자가 세균의 계통적 관계를 잘 반영하는 연대기적 분자 표지가 되기 위해서는, 표적 유전자가 모든 세균에서 기능적으로 필수적이고 보존되어야 하고, 후천적 영향에 의한 균 종간 염기서열의 변이가 일어나지 않으며, 계통 관계를 나타내기에 적절한 종 간 다양성 (interspecies variation)과 같은 속 내의 균종 사이의 보존성 (intraspecies conservation)을 보여야 한다. rpoB 유전자의 경우 세균의 전사에 관여하는 필수 효소를 코딩하므로 모든 균주에 필수적이고 보존되어 있으며, 균 종간 염기서열의 변이가 잘 일어나지 않고, 다른 속 균주들에서 다양성과 보존성이 보고되어 있으므로 (Kim 등, J Clin Microbiol 37:1714-1720, 1999; Lee 등, J Clin Microbiol 38:2557-2562, 2000), 분자 표지로 적절하다. 또한, 종래에 rpoB 유전자의 염기서열 중에서 고변이 부위에 해당하는 약 300bp 정도의 부분적 염기서열을 사용하여 살모넬라 아종을 구분하는 것이 보고되었으나 (Kwon 등, Veterinary Microbiology, 2001, 82: 121- 129), 살모넬라의 일부 아종의 구분에만 적용 가능하고 구분 능력이 상대적으로 낮아 적용성이 낮은 문제가 있었다. 즉 상기의 rpoB의 일부분을 사용하는 경우 Agona와 Derby; Paratyphi A와 Typhi; Blockley와 Paratyphi B; Braenderup, Hadar 와 Infantis; Enteritidis와 Gallinarum; Kentucky와 Senftenberg; Give와 Montevideo가 구분되지 않는 문제점이 있다.
본 발명과 같이 rpoB 유전자의 전체 염기서열을 분석하여 혈청형 동정에 사용할 경우, 보존된 부분에서 유래된 프라이머를 사용하므로 지금까지 알려진 모든 살모넬라 균주들에 적용가능하며, 도 1및 표 3에 나타난 바와 같이 정확히 혈청형을 구분할 수 있다. 본 발명의 구체적인 실시예에서 볼 수 있듯이, 본 발명에서는 기존의 방법으로는 혈청형을 동정할 수 없었던 균주들의 혈청형 동정이 가능하였고 (예, B21, B22 균주), 기존 방법에 의한 혈청형 동정법으로는 구분이 되지 않는 균주들에서 염기서열의 차이를 확인하여 아군(subtype)으로 세부 분류가 가능하였다 (예, S1 및 A3; B1, B4, B5, B9, B7 및 B21; B13 및 B14; SL317, C1, C22, S50, 및 SL254; E3, E4 및 E5; E1, E2 및 S87).
따라서, 본 발명은 rpoB 유전자의 전체 염기서열을 증폭 또는 결정할 수 있는 프라이머를 제공한다.
본 발명에서 rpoB 유전자의 전체 염기서열을 증폭 또는 결정할 수 있는 프라이머는, 살모넬라 속 균주의 rpoB 유전자 전체를 증폭 또는 결정할 수 있는 프라이머로서, 바람직하게는 살모넬라 속 미생물의 rpoB 유전자의 염기서열 (서열번호 15)중에서 표 1에 기재된 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머일 수 있다.
보다 바람직하게, 본 발명에서 rpoB 유전자의 전체 염기서열을 증폭할 수 있는 프라이머는, 모든 살모넬라 속 균주의 rpoB 유전자 전체를 증폭시킬 수 있는 프라이머로서, 바람직하게 서열번호 1 (Sal-rpoB-preF) 및 서열번호 2 (Sal-rpoB-postR) 의 염기서열을 가지는 프라이머 쌍, 또는 서열번호 3 (Sal-rpoB-F) 및 서열번호 4 (Sal-rpoB-R)의 염기서열을 가지는 프라이머 쌍일 수 있다.
또한, 보다 바람직하게, 본 발명에서 rpoB 유전자의 전체 염기서열을 결정하기 위한 프라이머는, 모든 살모넬라 속 균주의 rpoB 유전자 전체를 결정할 수 있는 프라이머로서,서열번호 5 (salrpoB-PIR), 서열번호 5 (salrpoB-PIR), 서열번호 6 (salrpoB-P2), 서열번호 7 (salrpoB-P3), 서열번호 8 (salrpoB-P4), 서열번호 9 (salrpoB-P5), 서열번호 10 (salrpoB-P6), 서열번호 11 (salrpoB-P7), 서열번호 12 (salrpoB-PN3), 서열번호 13 (salrpoB-PN4) 및 서열번호 14 (salrpoB-PN5) 의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 프라이머일 수 있다.
본 발명의 프라이머는 살모넬라 혈청형들의 rpoB 유전자의 전체 염기서열을 증폭하고 염기서열을 결정하기 위한 최초의 프라이머들로, GenBank에 등록된 살모넬라 혈청형 균주 44 주의 rpoB 게놈 서열을 다중배열하여 확인한 보존 부분을 토대로 하여 rpoB 전체 염기서열을 증폭 및 결정할 수 있도록 고도로 계산되어 제조된 프라이머이다. 즉, 본 발명에서는 살모넬라 혈청형들 사이에서 rpoB 유전자의 보존된 부분을 최초로 확인하고 (표 1) 이를 토대로 하여 프라이머를 설계하였으며, 본 발명의 프라이머는 지금까지 알려진 모든 살모넬라 혈청형들에 적용할 수 있다.　
또한, 본 발명은 전세계적으로 빈발하는 살모넬라 속 미생물의 혈청형들에 특이적인 rpoB 의 전체 염기서열을 가지는 폴리뉴클레오티드를 제공한다.　
바람직하게, 본 발명에서 제공하는 rpoB 폴리뉴클레오티드는, 서열번호 15내지 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 것이다. 상기 폴리뉴클레오티드는 본 발명의 rpoB 유전자의 증폭 및 결정용 프라이머들을 사용하여 확인된 것으로, 독자적인 살모넬라 혈청형 동정용 데이터베이스를 구축할 수 있다.
특히, 이 중에서 서열번호 15, 서열번호 16, 서열번호 17, 서열번호 19, 서열번호 20, 서열번호 21, 서열번호 22, 서열번호 24, 서열번호 25, 서열번호 26, 서열번호 28, 서열번호 31, 서열번호 32, 서열번호 33, 서열번호 34, 서열번호 38, 서열번호 43, 서열번호 44, 서열번호 45, 서열번호 47, 서열번호 49, 서열번호 50, 서열번호 51, 서열번호 54, 서열번호 55, 서열번호 56, 서열번호 57, 서열번호 59, 서열번호 60, 서열번호 61, 서열번호 63, 서열번호 64, 서열번호 65, 서열번호 66, 서열번호 67, 서열번호 68, 서열번호 70, 서열번호 74 및 서열번호 75의 염기서열은 Genbank 검색 상에서 새로운 염기서열로 밝혀졌다.
따라서, 보다 바람직하게, 본 발명에서 제공하는 rpoB 폴리뉴클레오티드는 서열번호 15, 서열번호 16, 서열번호 17, 서열번호 19, 서열번호 20, 서열번호 21, 서열번호 22, 서열번호 24, 서열번호 25, 서열번호 26, 서열번호 28, 서열번호 31, 서열번호 32, 서열번호 33, 서열번호 34, 서열번호 38, 서열번호 43, 서열번호 44, 서열번호 45, 서열번호 47, 서열번호 49, 서열번호 50, 서열번호 51, 서열번호 54, 서열번호 55, 서열번호 56, 서열번호 57, 서열번호 59, 서열번호 60, 서열번호 61, 서열번호 63, 서열번호 64, 서열번호 65, 서열번호 66, 서열번호 67, 서열번호 68, 서열번호 70, 서열번호 74 및 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 살모넬라 속 미생물의 rpoB 폴리뉴클레오티드이다.
본 발명에서 분석된 서열번호 15 내지 75의 염기서열을 다중배열하여 서로의 염기서열을 비교해본 결과, 모두 다른 염기서열을 가지고 있어 종간 염기서열 다양성(interspecies variation)을 나타내었으며, 모두 다중배열 상에서 염기서열의 삽입이나 결실 없이 4029bp의 염기를 코딩하고 있었으므로, rpoB 의 전체 염기서열이 연대기적 분자 표지로 적합함을 확인할 수 있다. 또한, 상기 폴리뉴클레오티드의 전체 염기서열 및 이를 포함하는 해당 균주의 혈청형을 미리 알고 있으므로, 이 염기서열을 기준으로 하여 분석 대상 균주의 rpoB 염기서열과 비교함으로써 분석 대상 균주의 혈청형을 결정하고 계통 관계를 분석하는 데 사용될 수 있다.
따라서, 본 발명은 상기 프라이머 및 rpoB 폴리뉴클레오티드 염기서열을 이용하여 살모넬라 속 미생물의 혈청형을 동정하는 방법을 제공한다.
구체적으로, 상기 살모넬라 속 미생물의 혈청형을 동정하는 방법은 rpoB 유전자의 전체 염기서열을 증폭하는 단계를 포함한다.
바람직하게, 상기 살모넬라 속 미생물의 혈청형을 동정하는 방법은 다음의 단계를 포함한다:
(1) 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하는 단계;
(2) 상기 증폭된 rpoB 유전자의 전체 염기서열을 결정하는 단계;
(3) 상기 단계 (2)에서 얻어진 염기서열을 표준 균주의 rpoB 유전자의 염기서열과 비교하여 혈청형을 결정하는 단계.
상기 단계 (1)은 동정하고자 하는 미지의 살모넬라 균주, 즉 목적 균주의 rpoB 유전자의 전체 염기서열을 증폭하는 단계이다.
바람직하게, 상기 단계는 rpoB 유전자의 전체 염기서열을 증폭할 수 있는 프라이머로서, 표 1에 기재된 rpoB 유전자 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머를 이용한 PCR 증폭에 의하여 수행할 수 있다.
보다 바람직하게, 상기 단계는 rpoB 유전자의 전체 염기서열을 증폭할 수 있는 프라이머로서, 서열번호 1 (Sal-rpoB-preF) 및 서열번호 2 (Sal-rpoB-postR) 의 염기서열을 가지는 프라이머 쌍, 또는 서열번호 3 (Sal-rpoB-F) 및 서열번호 4 (Sal-rpoB-R)의 염기서열을 가지는 프라이머 쌍을 이용한 PCR 증폭에 의하여 수행할 수 있다. PCR 증폭은 본 기술분야의 전문가에게 알려진 분석법을 모두 사용할 수 있다.
상기 단계 (2)는 상기 단계 (1) 에서 증폭된 rpoB 유전자의 전체 염기서열을 결정하기 위한 프라이머로서, 바람직하게는 표 1에 기재된 rpoB 유전자 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머를 사용하여 수행할 수 있으며, 보다 바람직하게는, 서열번호 5 내지 서열번호 14의 염기서열로 이루어진 군으로부터 선택되는 염기서열을 가지는 1종 이상의 프라이머를 이용한 PCR 증폭산물 정제 키트 등에 의하여 수행할 수 있다.
상기 단계 (3)은 상기 단계 (2)에서 얻어진 염기서열을 표준 균주의 rpoB 유전자의 염기서열과 비교하여 혈청형을 결정하는 단계로, 바람직하게, 상기 표준 균주의 rpoB 유전자의 염기서열은 서열번호 15 내지 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 것이다. 상기 서열번호 15 내지 서열번호 75의 염기서열을 가지는 폴리뉴클레오티드는 본 발명의 rpoB 유전자의 증폭 및 결정용 프라이머들을 사용하여 확인된 것으로, 그 전체 염기서열 및 해당 균주의 혈청형을 미리 알고 있으므로, 상기 염기서열을 기준으로 하여 목적 균주의 rpoB 염기서열과 비교함으로써 목적 균주의 혈청형을 결정하고 계통 관계를 분석할 수 있다. 표준 균주와 목적 균주의 rpoB 전체 염기서열의 차이를 이용한 분자 생물학적 방법은 모두 본 발명에 적용할 수 있다.
바람직한 일예로, 목적 균주의 rpoB 염기서열을 분석한 후에 이를 표준 균주의 rpoB 염기서열 비교하여 목적 균주의 혈청형을 결정하기 위하여, 미리 구축된 표준 균주의 rpoB 염기서열이 정렬된 데이타베이스에 동정하고자 하는 균의 rpoB염기서열을 추가시키고, 다시 염기서열 정렬을 수행하여 계통도를 완성할 수 있다. 계통도가 완성되면 해당되는 균종에 근접하여 가지를 형성하게 되므로 계통도로 혈청형을 결정할 수 있다. 상기 계통도를 완성하기 위하여, Mega 소프트웨어 등을 이용한 Neighbor-joining 방법을 사용할 수 있으며, 계통 가지의 지지도는 부트스트랩 분석(bootstrap replications)을 100회 내지 1000회 반복 시행하여 결정할 수 있다.
상기 혈청형 동정 방법에 의하여, 식중독 환자 또는 주변 환경으로부터 살모넬라로 의심되는 미지의 균이 분리되었을 때, 특이적 프라이머로 rpoB 전체 염기서열을 증폭 및 결정하고, 이를 이미 확보한 표준 균주들의 염기서열과 비교함으로써 균종을 판별할 수 있으며, 종래의 균종 동정 방법에 비해 보다 정확하게 이루어지게 되어 살모넬라에 감염된 환자의 치료 방침이 신속하게 결정될 수 있다.
본 발명은 또한, 상기 기술한 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공한다.
바람직하게, 본 발명은 살모넬라 속 미생물의 rpoB 유전자의 염기서열 (서열번호 15)중에서 표 1에 기재된 보존 부분의 염기 서열에 상보적이며 7 내지 50 bp 의 연속된 염기서열을 가지는 프라이머를 포함하는, 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공한다.
또한 바람직하게, 본 발명은 서열번호 1 및 2, 또는 서열번호 3 및 4의 염기서열을 가지는, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 증폭용 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공한다. 보다 바람직하게, 상기 조성물은 서열번호 5 내지 서열번호 14의 염기서열로 이루어진 군으로부터 선택되는 rpoB 유전자의 전체 염기서열 결정용 프라이머를 추가로 포함할 수 있다.
또한 바람직하게, 본 발명은 서열번호 5 내지 서열번호 14의 염기서열로 이루어진 군으로부터 선택되는 rpoB 유전자의 전체 염기서열 결정용 프라이머를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물을 제공한다.
본 발명은 또한, 상기 조성물을 포함하는 살모넬라 속 미생물의 혈청형 동정용 키트를 제공한다. 바람직하게, 상기 키트는 PCR-RFLP (restriction fragment length polymorphism) 키트, allele-specific PCR 키트, 실시간 PCR 키트, DNA 칩 키트 또는 서던 블랏팅 키트일 수 있다. 상기 키트는 상기 프라이머 외에도, DNA 중합효소, DNA 염색 시약 또는 적합한 담체를 추가로 포함할 수 있다.
본 발명인 rpoB 유전자의 전체 염기서열을 분석하여 살모넬라 혈청형을 동정하는 기술은, 기존의 항혈청을 이용한 복잡한 혈청형 결정법과 비교하여 보다 객관적이고 정확한 결과를 얻을 수 있고, 모든 살모넬라 균주에 광범위하게 적용할 수 있으며, 과정이 단순하고 시간과 비용을 절약할 수 있어 살모넬라 혈청형 동정에 유용하게 사용될 수 있다.
도 1은 살모넬라 혈청형들의 rpoB 유전자 코딩 부분의 전체 염기서열을 사용하여 계통분석 (Neighbor-joining method; Tamura-Nei distance; bootstrapping 100 repeats) 한 결과를 나타낸다.
도 2는 본 발명의 증폭용 프라이머를 사용하여 Salmonella Enteritidis, Salmonella Gallinarum, Salmonella Pullorum, Salmonella Typhimurium의 rpoB 전체 염기서열을 증폭한 후 StyI, FspI, MnlI을 처리하여 한천 겔에서 전기영동 함으로써 감별진단 한 PCR-RFLP 결과를 나타낸다.
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 실시예에 의해 한정되는 것은 아니다.
실시예 1. 프라이머의 설계 및 살모넬라 혈청형의 동정
1-1. 살모넬라 혈청형의 전체 rpoB 증폭용 및 염기서열 결정용 프라이머의 설계
GenBank에 등록되어 있는 살모넬라 균주 44주의 rpoB 염기서열 Typhimurium LT2(NC 003197), Paratyphi B SPB7 (NC_010102), Paratyphi A ATCC9150 (NC 006511), Typhi Ty2 (NC 004631), Enteritidis P125109 (NC 011294), Gallinarum 287/91 (NC 011274), Paratyphi A AKU-12601 (NC_011147), Typhi CT18 (NC 003198), Paratyphi C RKS4594 (NC 012125), Dublin CT-02021853 (NC 011205), Agona SL483 (NC_011149), Schwarzengrund CVM19633 (NC 011094), Heidelberg SL476 (NC_011083), Newport SL254 (NC 011080), Tennesee CDC07-0191 (NZ ACBF01000033), Pullorum SP12 (FJ797633), Enteritidis SE4 (FJ797617), Enteritidis SE14 (FJ797618), Enteritidis SE38 (FJ797619), Enteritidis SE40 (FJ797620), Enteritidis SE43 (FJ797621), Gallinarum SG52 (FJ797622), Gallinarum SG60 (FJ797623), Gallinarum SG101 (FJ797624), Gallinarum SG4041 (FJ797625), Gallinarum SG4160 (FJ797626), Gallinarum SG5132 (FJ797627), Gallinarum SG6039 (FJ797628), Pullorum SP1 (FJ797629), Pullorum SP4 (FJ797630), Pullorum SP5 (FJ797631), Pullorum SP11 (FJ797632), Typhimurium ST17 (FJ797634), Typhimurium ST18 (FJ797635), Typhimurium ST19 (FJ797636), Typhimurium ST21 (FJ797637), Javiana (ABEH02000013), Hadar RI-05P066 (NZ ABFG01000019), Weltevreden HI-N05/537 (NZ ABFF01000047), Heidelberg SL486 (NZ ABEL01000038), Virchow SL491 (NZ ABFH02000001), Saintpaul SARA23 (NZ ABAM02000001), Newport SL317 (NZ_ABEW01000017) 및 Kentucky CVM29188 (NZ ABAK02000001)을 다중배열 하여, 혈청형 간 차이를 보이는 rpoB 유전자의 변이 부분과 보존된 부분을 확인하였으며, 이를 표 1 및 표 2에 나타내었다.
보존부분 염기서열 돌연변이 보존부분 염기서열 돌연변이
1-139 A140G, C145T 2275-2306 A2307G, T2310C, G2313A, A2334G, C2343T, C2345T, T2358C, T2376C, C2380T, G2385A, C2388A, G2394C
146-251 A252G, C267T 2404-2447 T2448C, T2454A/C, T2466G, C2469T
268-341 A342T 2470-2522 T2623C, G2535A
343-380 T381C, C393T 2536-2558 T2559C, T2580G
394-422 T423C, C435T, C445T, C456T, T459G 2581-2616 A2617C, C2619T, C2622T, G2631A, A2634C/T, T2640C
460-491 C492T 2641-2660 G2661A, C2679G, G2682A
493-524 C525T 2683-2718 G2719C
526-587 A588G, C594T, T606C, A612G, A619C, A622T, C624T, C627T 2720-2749 C2750T
628-647 C648T, C660T, A665T, C684G/T 2751-2783 T2784G
685-707 A708G 2785-2835 C2836T
709-739 G740T, T741C, C750T 2837-2889 C2890T, G2895A, C2901T
751-770 T771G, C774T, A780G, C798T 2902-2933 G2934A, C2935T, T2940G, A2944G
799-818 C819T, C829T 2945-2984 C2985T
842-878 G841T, A879G, T882C, C891T, C909T, T915C, T918A 2986-3028 A3029C, A3036G
919-971 G972A, C973T, C984T, G993A 3035-3059 A3060G, A3081G, T3087G
994-1061 C1062T, T1068C, C1078T 3088-3111 C3112A
1079-1100 C1101T 3113-3149 G3150T
1102-1130 A1131T, C1134T, G1140A, T1155C, C1170T, C1173G 3151-3206 T3207C, T3222G
1174-1202 T1203G, G1212A, C1228T, C1233T, C1251T, A1264G, C1275T, C1284T, G1290A 3223-3260 C3261T
1291-1367 G1380A, C1402T 3283-3326 C3327T, C3330T
1403-1472 T1473C, C1485T, C1500G 3331-3362 G3363A, T3372C, C3378T, T3384C
1501-1559 T1584C 3385-3416 G3417C, G3423A
1561-1583 C1608T, C1617T, C1620T 3424-3443 C3444T, C3456A
1621-1652 C1653T, G1659T, T1668G, A1674G, T1680A 3457-3486 A3487T
1681-1709 T1710C, C1716T, C1722G, C1728T 3488-3506 G3507T, A3519T, C3531T, A3533T, T3546C, C3549A, A3552G, T3561C
1729-1754 C1755T 3562-3608 C3609T, C3618A/T, C3634T, G3636C, C3645T
1756-1796 T1797C 3646-3756 C3757T, G3771A, G3789C
1798-1844 T1845C, C1848T 3790-3821 A3822G, C3832T
1849-1895 T1896C, T1897C, G1902A/T, C1905G 3833-3854 C3855T
1906-1940 C1941T, C1953T, T1965A 3865-3896 T3897C, T3900C, C3906T
1966-2006 G2007A, C2025T, C2028T, A2037G, T2046G 3907-3926 G3927A
2047-2066 C2082T, C2088T 3928-3947 A3948G
2089-2186 G2187A 3949-3986 G3987A
2188-2231 C2232T, G2238A 3988-4019 A4020G, G4021A
2239-2261 C2262T, C2268T, C2274T
본 발명자들이 제공한 표 1 및 표 2의 정보를 토대로 하여, 상기 돌연변이 부분은 DNA 칩, allele-specific PCR, RFLP 및 서던 블랏팅 등을 이용한 혈청형 동정에 유용하게 활용될 수 있고, 보존된 부분은 다양한 혈청형 균주의 염기서열 증폭과 염기서열 결정(sequencing)을 위한 새로운 프라이머 설계에 활용할 수 있다. 본 발명자들은 rpoB 전체 유전자를 증폭할 수 있는 최적의 프라이머로 Sal-rpoB-preF (rpoB 개시 코돈의 업스트림 비코딩 영역, 서열번호 1) 및 Sal-rpoB-postR (rpoB 종결 코돈의 다운스트림 비코딩 영역, 서열번호 2), Sal-rpoB-F (서열번호 3) 및 Sal-rpoB-R (서열번호 4) 의 프라이머 쌍을 설계하였고, 상기 보존 부분을 토대로 하여 염기서열 결정용 프라이머로 Sal-rpoB-P1R (서열번호 5), Sal-rpoB-P2 (서열번호 6), Sal-rpoB-P3 (서열번호 7), Sal-rpoB-P4 (서열번호 8), Sal-rpoB-P5 (서열번호 9), Sal-rpoB-P6 (서열번호 10) 및 Sal-rpoB-P7 (서열번호 11)을 설계하였으며, 질병관리본부 국립보건원 장내세균팀에서 제공한 살모넬라 72주에 대한 염기서열을 결정하면서 Sal-rpoB-P3 (서열번호 7), Sal-rpoB-P4 (서열번호 8) 및 Sal-rpoB-P5 (서열번호 9) 프라이머를 개선한 Sal-rpoB-P3N (서열번호 12), Sal-rpoB-P4N (서열번호 13) 및 Sal-rpoB-P5N (서열번호 14) 을 설계하였다.
1-2. 살모넬라 혈청형의 전체 rpoB 염기서열 결정 및 혈청형 동정
질병관리본부 국립보건원 장내세균팀에서 제공한 살모넬라 73주를 LB 육즙배지에서 종야 배양하여 1ml를 1.5ml microcentrifuge 튜브에 분주하여 3,500xg에서 10분간 원심분리 한 후 배지를 제거하였고, 남은 세균 펠렛으로부터 전체 DNA를 BioPOA의 GenomEx 키트를 사용하여 추출한 후 rpoB를 PCR을 이용하여 증폭하였다. PCR 반응액은 10 X buffer 5㎕, dNTPs (2.5mM each) 1㎕, Sal-rpoB-preF (서열번호 1) 및 Sal-rpoB-postR (서열번호 2) 각각 (10pmol/ul) 1.0㎕, Taq DNA polymerase(5U/㎕; MACROGEN Co., Seoul, ROK) 0.5㎕, DW 40.5㎕, template DNA (50ng/㎕) 1㎕ 이었고, 온도는 94 -4분, ( 94℃-30초, 54℃-20초, 72℃-4분30초)x40회, 72℃-5min 반응하였다. 그 결과 모든 살모넬라 혈청형에서 4,029bp의 특이적인 증폭산물이 확인되었고, 이들을 PCR 증폭산물 정제키트(BioPOA Co., 용인)를 사용하여 염기서열을 결정(MACROGEN Co.) 하였다. 염기서열 결정을 위한 프라이머로는 Sal-rpoB-P1R (서열번호 5), Sal-rpoB-P2 (서열번호 6), Sal-rpoB-P3N (서열번호 12), Sal-rpoB-P4N (서열번호 13), Sal-rpoB-P5N (서열번호 14), Sal-rpoB-P6 (서열번호 10) 및 Sal-rpoB-P7 (서열번호 11) 이 최적이었다. 결정된 염기서열을 MEGA 5 프로그램을 사용하여 다중배열 한 후 Neighbor-joining method(Tamura-Nei distance; 100 repeats of bootstrapping)로 계통분석 하였으며, 그 결과를 도 1 및 표 3에 나타내었다.
하기 표 3은 각 균주들에 대하여 기존의 혈청학적 방법에 의하여 동정한 혈청형과, 본 발명의 방법에 의한 rpoB 타이핑으로 동정한 혈청형을 나타내며, 본 발명에서 확인한 균주들의 rpoB 염기서열은 서열번호 15내지 서열번호 75로 표시하였다.
본 발명자들이 제공한 표 1 및 표 2의 정보를 토대로 하여, 상기 돌연변이 부분은 DNA 칩, allele-specific PCR, RFLP 및 서던 블랏팅 등을 이용한 혈청형 동정에 유용하게 활용될 수 있고, 보존된 부분은 다양한 혈청형 균주의 염기서열 증폭과 염기서열 결정(sequencing)을 위한 새로운 프라이머 설계에 활용할 수 있다. 본 발명자들은 rpoB 전체 유전자를 증폭할 수 있는 최적의 프라이머로 Sal-rpoB-preF (rpoB 개시 코돈의 업스트림 비코딩 영역, 서열번호 1) 및 Sal-rpoB-postR (rpoB 종결 코돈의 다운스트림 비코딩 영역, 서열번호 2), Sal-rpoB-F (서열번호 3) 및 Sal-rpoB-R (서열번호 4) 의 프라이머 쌍을 설계하였고, 상기 보존 부분을 토대로 하여 염기서열 결정용 프라이머로 Sal-rpoB-P1R (서열번호 5), Sal-rpoB-P2 (서열번호 6), Sal-rpoB-P3 (서열번호 7), Sal-rpoB-P4 (서열번호 8), Sal-rpoB-P5 (서열번호 9), Sal-rpoB-P6 (서열번호 10) 및 Sal-rpoB-P7 (서열번호 11)을 설계하였으며, 질병관리본부 국립보건원 장내세균팀에서 제공한 살모넬라 72주에 대한 염기서열을 결정하면서 Sal-rpoB-P3 (서열번호 7), Sal-rpoB-P4 (서열번호 8) 및 Sal-rpoB-P5 (서열번호 9) 프라이머를 개선한 Sal-rpoB-P3N (서열번호 12), Sal-rpoB-P4N (서열번호 13) 및 Sal-rpoB-P5N (서열번호 14) 을 설계하였다.
1-2. 살모넬라 혈청형의 전체 rpoB 염기서열 결정 및 혈청형 동정
질병관리본부 국립보건원 장내세균팀에서 제공한 살모넬라 73주를 LB 육즙배지에서 종야 배양하여 1ml를 1.5ml microcentrifuge 튜브에 분주하여 3,500xg에서 10분간 원심분리 한 후 배지를 제거하였고, 남은 세균 펠렛으로부터 전체 DNA를 BioPOA의 GenomEx 키트를 사용하여 추출한 후 rpoB를 PCR을 이용하여 증폭하였다. PCR 반응액은 10×buffer 5㎕, dNTPs (2.5mM each) 1㎕, Sal-rpoB-preF (서열번호 1) 및 Sal-rpoB-postR (서열번호 2) 각각 (10pmol/ul) 1.0㎕, Taq DNA polymerase(5U/㎕; MACROGEN Co., Seoul, ROK) 0.5㎕, DW 40.5㎕, template DNA (50ng/㎕) 1㎕ 이었고, 온도는 94 -4분, ( 94℃-30초, 54℃-20초, 72℃-4분30초)x40회, 72℃-5min 반응하였다. 그 결과 모든 살모넬라 혈청형에서 4,029bp의 특이적인 증폭산물이 확인되었고, 이들을 PCR 증폭산물 정제키트(BioPOA Co., 용인)를 사용하여 염기서열을 결정(MACROGEN Co.) 하였다. 염기서열 결정을 위한 프라이머로는 Sal-rpoB-P1R (서열번호 5), Sal-rpoB-P2 (서열번호 6), Sal-rpoB-P3N (서열번호 12), Sal-rpoB-P4N (서열번호 13), Sal-rpoB-P5N (서열번호 14), Sal-rpoB-P6 (서열번호 10) 및 Sal-rpoB-P7 (서열번호 11) 이 최적이었다. 결정된 염기서열을 MEGA 5 프로그램을 사용하여 다중배열 한 후 Neighbor-joining method(Tamura-Nei distance; 100 repeats of bootstrapping)로 계통분석 하였으며, 그 결과를 도 1 및 표 3에 나타내었다.
하기 표 3은 각 균주들에 대하여 기존의 혈청학적 방법에 의하여 동정한 혈청형과, 본 발명의 방법에 의한 rpoB 타이핑으로 동정한 혈청형을 나타내며, 본 발명에서 확인한 균주들의 rpoB 염기서열은 서열번호 15 내지 서열번호 75로 표시하였다.
균주 혈청형
(기존의 방법)		 rpoB type
(본 발명의 방법)		 rpoB subtype
(본 발명의 방법)		 서열번호 출처
B1 Typhimurium Typhimurium Typhimurium-1 서열번호 15 질병관리본부
B4 Typhimurium Typhimurium Typhimurium-2 서열번호 16 질병관리본부
B6 Typhimurium Typhimurium Typhimurium-2 질병관리본부
B8 Typhimurium Typhimurium Typhimurium-2 질병관리본부
B10 Typhimurium Typhimurium Typhimurium-2 질병관리본부
B5 Typhimurium Typhimurium Typhimurium-3 서열번호 17 질병관리본부
B9 Typhimurium Typhimurium Typhimurium-4 서열번호 18 질병관리본부
ST17 Typhimurium Typhimurium Typhimurium-4 GenBank
ST21 Typhimurium Typhimurium Typhimurium-4 GenBank
LT2 Typhimurium Typhimurium Typhimurium-4 GenBank
B7 Typhimurium Typhimurium Typhimurium-5 서열번호 19 질병관리본부
B21 Untypable Typhimurium Typhimurium-6 서열번호 20 질병관리본부
B22 Untypable Typhimurium Typhimurium-6 질병관리본부
C9 Hartford Hartford 서열번호 21 질병관리본부
C5 Braenderup Braenderup 서열번호 22 질병관리본부
SL317 Newport Newport Newport-1 서열번호 23 GenBank
C7 Infantis Infantis 서열번호 24 질병관리본부
C15 Thompson Thompson 서열번호 25 질병관리본부
S40 Thompson Thompson 질병관리본부
E8 Anatum Anatum 서열번호 26 질병관리본부
S84 Anatum Anatum 질병관리본부
A3 Paratyphi A Paratyphi A Paratyphi A-1 서열번호 27 질병관리본부
AKU12601 Paratyphi A Paratyphi A Paratyphi A-1 GenBank
ATCC9150 Paratyphi A Paratyphi A Paratyphi A-1 GenBank
S1 Paratyphi A Paratyphi A Paratyphi A-2 서열번호 28 질병관리본부
D13 Typhi Typhi Typhi-1 서열번호 29 질병관리본부
D14 Typhi Typhi Typhi-1 질병관리본부
D15 Typhi Typhi Typhi-1 질병관리본부
D16 Typhi Typhi Typhi-1 질병관리본부
D18 Typhi Typhi Typhi-1 질병관리본부
D22 Typhi Typhi Typhi-1 질병관리본부
D23 Typhi Typhi Typhi-1 질병관리본부
Ty2 Typhi Typhi Typhi-1 GenBank
CT18 Typhi Typhi Typhi-2 서열번호 30 GenBank
S57 Typhi Typhi Typhi-3 서열번호 31 질병관리본부
C2 Blockley Blockley 서열번호 32 질병관리본부
C21 Blockley Blockley 질병관리본부
C3 Litchfield Litchfield 서열번호 33 질병관리본부
B20 Stanley Stanley 서열번호 34 질병관리본부
B17 Paratyphi B Paratyphi B 서열번호 35 질병관리본부
S3 Paratyphi B Paratyphi B 질병관리본부
SPB7 Paratyphi B Paratyphi B GenBank
CVM29188 Kentucky Kentucky 서열번호 36 GenBank
CDC07-0191 Tennesee Tennesee 서열번호 37 GenBank
B13 Derby Derby Derby-1 서열번호 38 질병관리본부
D1 Enteritidis Enteritidis 서열번호 39 질병관리본부
D5 Enteritidis Enteritidis 질병관리본부
D7 Enteritidis Enteritidis 질병관리본부
D8 Enteritidis Enteritidis 질병관리본부
D9 Enteritidis Enteritidis 질병관리본부
D10 Enteritidis Enteritidis 질병관리본부
D24 Enteritidis Enteritidis 질병관리본부
SE4 Enteritidis Enteritidis GenBank
P125109 Enteritidis Enteritidis GenBank
SP1 Pullorum Pullorum 서열번호 40 GenBank
SG52 Gallinarum Gallinarum 서열번호 41 GenBank
287/91 Gallinarum Gallinarum GenBank
E6 Weltevreden Weltevreden 서열번호 42 질병관리본부
E7 Weltevreden Weltevreden 질병관리본부
HI-N05-537 Weltevreden Weltevreden GenBank
C1 Newport Newport Newport-2 서열번호 43 질병관리본부
C22 Newport Newport Newport-3 서열번호 44 질병관리본부
D25 Dublin Dublin Dublin-1 서열번호 45 질병관리본부
CT02021853 Dublin Dublin Dublin-2 서열번호 46 GenBank
S50 Newport Newport Newport-4 서열번호 47 질병관리본부
SL254 Newport Newport Newport-5 서열번호 48 GenBank
E4 London London London-1 질병관리본부
E5 London London London-1 질병관리본부
E3 London London London-2 서열번호 49 질병관리본부
C4 Rissen Rissen Rissen-1 서열번호 50 질병관리본부
C10 Rissen Rissen Rissen-2 서열번호 51 질병관리본부
C11 Rissen Rissen Rissen-2 질병관리본부
C19 Hadar Hadar 서열번호 52 질병관리본부
RI05P066 Hadar Hadar GenBank
RKS4594 Paratyphi C Paratyphi C 서열번호 53 GenBank
C13 Bareilly Bareilly 서열번호 54 질병관리본부
E1 Senftenberg Senftenberg Senftenberg-1 서열번호 55 질병관리본부
E2 Senftenberg Senftenberg Senftenberg-1 질병관리본부
B16 Paratyphi B Java Paratyphi B Java 서열번호 56 질병관리본부
C18 Ohio Ohio 서열번호 57 질병관리본부
ABEH02000013 Javiana Javiana 서열번호 58 GenBank
S76 London London London-3 서열번호 59 질병관리본부
D26 Panama Panama 서열번호 60 질병관리본부
B18 Muenchen Muenchen 서열번호 61 질병관리본부
B19 Schwarzengrund Schwarzengrund 서열번호 62 질병관리본부
CVM19633 Schwarzengrund Schwarzengrund GenBank
B23 Brandenburg Brandenburg 서열번호 63 질병관리본부
C8 Montevideo Montevideo 서열번호 64 질병관리본부
E9 Give Give 서열번호 65 질병관리본부
C16 Mbandaka Mbandaka 서열번호 66 질병관리본부
S87 Senftenberg Senftenberg Senftenberg-2 서열번호 67 질병관리본부
B15 Agona Agona Agona-1 서열번호 68 질병관리본부
SL483 Agona Agona Agona-2 서열번호 69 GenBank
B14 Derby Derby Derby-2 서열번호 70 질병관리본부
SL476 Heidelberg Heidelberg 서열번호 71 GenBank
SL486 Heidelberg Heidelberg GenBank
SARA23 Saintpaul Saintpaul 서열번호 72 GenBank
C12 Virchow Virchow 서열번호 73 질병관리본부
SL491 Virchow Virchow GenBank
B24 Scheleissheim Scheleissheim 서열번호 74 질병관리본부
D11 9,12:l,w:enx 9,12:l,w:enx 서열번호 75 질병관리본부
상기 표 3에 나타난 바와 같이, 기존의 혈청학적 방법에 의할 때 Typhimurium으로 분류된 B1, B4, B5, B6, B7, B8, B9, B10과 혈청학적으로 동정할 수 없었던 B21, B22는 GenBank에 등록된 Typhimurium인 LT2, ST17, ST21과 같은 클러스터를 형성하여 Typhimurium으로 분류되었으며 미세한 염기서열의 차이로 6개 아군, Typhimurium-1 (B1), Typhimurium-2 (B4=B6=B8=B10;), Typhimurium-3 (B5), Typhimurium-4 (B9=LT2=ST17=ST21), Typhimurium-5 (B7), Typhimurium-6 (B21=B22)로 세분되었다.
기존의 혈청학적 방법에 의할 때 Paratyphi A로 분류된 S1과 A3는 GenBank에 Paratyphi A로 등록된 AKU12601과 ATCC9150과 클러스터를 형성하여 Paratyphi A-1로 분류되었으며 S1은 나머지들과 미세한 염기서열 차이를 보여 Paratyphi A-2로 분류하였다.
기존의 혈청학적 방법에 의할 때 Typhi로 분류된 S57, D13, D14, D15, D16, D18, D22, D23은 GenBank에 Typhi로 등록된 Ty2와 CT18과 클러스터를 형성하여 Typhi로 분류되었으며 미세한 염기서열의 차이로 3개의 아군 Typhi-1 (D13=D14=D15=D16=D18=D22=D23=Ty2), Typhi-2 (CT18) , Typhi-3 (S57)으로 분류되었다.
기존의 혈청학적 방법에 의할 때 Enteritidis로 분류된 D1, D5, D7, D8, D9, D10, D24는 GenBank에 Enteritidis로 등록된 P125109와 SE4와 클러스터를 형성하여 Enteritidis로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Paratyphi B로 동정된 B17과 S3은 GenBank에 Paratyphi B로 등록된 SPB7과 클러스터를 형성하여 Paratyphi B로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Weltevreden으로 동정된 E6과 E7은 GenBank에 Weltevreden로 등록된 SPB7과 클러스터를 형성하여 Weltevreden로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Dublin으로 동정된 D25는 GenBank에 Dublin으로 등록된 CT 02021853과 클러스터를 형성하여 Dublin으로 분류되었으며 미세한 염기서열의 차이로 2개 아군 Dublin-1(D25)과 Dublin-2(CT02021853)로 세분되었다.
기존의 혈청학적 방법에 의할 때 Newport로 동정된 C1과 C22은 같은 클러스터를 형성하였으나 S50은GenBank에 Newport로 등록된 SL254와 함께 C1과 C22와 다른 클러스터를 형성하였고, GenBank에 Newport로 등록된 SL317은 이들과는 다른 클러스터를 형성하였으며 염기서열의 차이를 보여 Newport-1(SL317), Newport-2(C1), Newport-3(C22), Newport-4(S50), Newport-5(SL254)로 분류하였다.
기존의 혈청학적 방법에 의할 때 Hadar로 동정된 C19는 GenBank에 Hadar로 등록된 RI 05P066와 클러스터를 형성하여 Hadar로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Schwarzengrund로 동정된 B19는 GenBank에 Schwarzengrund로 등록된 CVM19633과 클러스터를 형성하여 Schwarzengrund로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Agona로 동정된 B15는 GenBank에 Agona로 등록된 SL483과 클러스터를 형성하여 Agona로 분류되었으며 미세한 염기서열의 차이를 보여 Agona-1(B15)과 Agona-2(SL483)로 분류되었다.
기존의 혈청학적 방법에 의할 때 Derby로 동정된 B13과 B14는 서로 다른 클러스터를 형성하여 Derby-1(B13)과 Derby-2(B14)로 분류되었다.
기존의 혈청학적 방법에 의할 때 London으로 동정된 E4, E5, E3 및 S76 중 E4, E5,는 같은 E3는 같은 클러스터를 형성하나 미세한 염기서열 차이를 보여 London-1(E4, E5)과 London-2(E3)로 세분되었고, 다른 클러스터를 형성한 S76은 London-3로 분류되었다.
기존의 혈청학적 방법에 의할 때 Rissen으로 동정된 C4, C10, C11은 같은 클러스터를 형성하였으나 미세한 염기서열의 차이를 보여 Rissen-1(C4)과 Rissen-2(C10, C11)로 세분되었다.
기존의 혈청학적 방법에 의할 때 Senftenberg로 동정된 E1, E2, 및 S87 중 E1, E2는 같은 클러스터를 형성하고, 동일한 염기서열을 보여 Senftenberg-1(E1, E2)으로 세분되었고, 다른 클러스터를 형성한 S87은 Senftenberg-2(S87)로 분류되었다. 기존의 혈청학적 방법에 의할 때 Virchow로 동정된 C12는 GenBank에 Virchow로 등록된 SL491과 클러스터를 형성하여 Virchow로 분류되었으며 이들은 모두 동일한 염기서열을 보였다.
기존의 혈청학적 방법에 의할 때 Thompson으로 동정된 C15와 S40; Anatum으로 동정된 E8과 S84; 및 Blockley로 동정된 C2와 C21 은 동일한 염기서열을 가지고 있었다.
C9(Hartford), C5(Braenderup), C7(Infantis), C3(Litchfield), B20(Stanley), C13(Bareilly), B16(Paratyphi B Java), C18(Ohio), D26(Panama), B18(Muenchen), B23(Brandenburg), C8(Montevideo), E9(Give), C16(Mbandaka), B24(Schleissheim) 및 D11(9,12:l,w:enx)은 특유의 염기서열을 가지고 있어 다른 살모넬라 혈청형들과 구분되었다.
GenBank에 등록된 살모넬라 혈청형 균주 중 Kentucky로 분류된 CVM29188; Tennesee로 분류된 CDC07-0191; Pullorum으로 분류된 SP1; Gallinarum으로 분류된 287/91과 SG52; Paratyphi C로 분류된 RKS4594; Javiana로 분류된 ABEH 02000013; Heidelberg로 분류된 SL476과 SL486; 및 Saintpaul로 분류된 SARA23은 본 발명에서 비교한 어떠한 살모넬라 혈청형과도 다른 고유의 염기서열을 가지고 있었다.
<110> SNU R&DB FOUNDATION <120> Primers for molecular identification of Salmonella serotype and method for identifying Salmonella serotype using the same <130> DPP20114741KR <160> 75 <170> KopatentIn 1.71 <210> 1 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-preF <400> 1 atagtgttgc acaaactgtc c 21 <210> 2 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-postR <400> 2 tgctcccgtc ggagttagca 20 <210> 3 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-F <400> 3 atggtttact cctataccga ga 22 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-R <400> 4 ttactcgtct tccagttcga 20 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P1R <400> 5 gttctggaat cagctccatc 20 <210> 6 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P2 <400> 6 ctgcgtgcgc tgaactaca 19 <210> 7 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P3 <400> 7 gaagttcaac cgttctctgc t 21 <210> 8 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P4 <400> 8 atcgaagaag gcaactacgt t 21 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P5 <400> 9 ttcatgccgt ggaacggcta 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P6 <400> 10 gtctgaccga cgaagagaaa 20 <210> 11 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-P7 <400> 11 gaagcggaaa tcaaagagct 20 <210> 12 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-PN3 <400> 12 agaccgctat gacctgtctg c 21 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-PN4 <400> 13 cattacctgt ctgctatcga 20 <210> 14 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Sal-rpoB-PN5 <400> 14 ctacaacttc gaagactcca 20 <210> 15 <211> 4029 <212> DNA <213> B1_Typhimurium-1 <400> 15 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgcc cttcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccagcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 16 <211> 4029 <212> DNA <213> B4_Typhimurium-2 <400> 16 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccagcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 17 <211> 4029 <212> DNA <213> B5_Typhimurium-3 <400> 17 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcacaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccagcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 18 <211> 4029 <212> DNA <213> B9_Typhimurium-4 <400> 18 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tacctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccagcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 19 <211> 4029 <212> DNA <213> B7_Typhimujrium-5 <400> 19 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccagcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 20 <211> 4029 <212> DNA <213> B21_Typhimurium-6 <400> 20 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gacaggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 21 <211> 4029 <212> DNA <213> C9_Hartford <400> 21 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagccctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgttg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact cgctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggwgatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 22 <211> 4029 <212> DNA <213> C5_Braenderup <400> 22 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggtgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcg 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 23 <211> 4029 <212> DNA <213> SL317 Newport-1 (NZ_ABEW01000017) <400> 23 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg agtgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 24 <211> 4029 <212> DNA <213> C7_Infantis <400> 24 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 25 <211> 4029 <212> DNA <213> C15_Thompson <400> 25 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccattct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggc cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 26 <211> 4029 <212> DNA <213> E8_Anatum <400> 26 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 27 <211> 4029 <212> DNA <213> A3_Paratyphi_A-1 <400> 27 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa ctcactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg atccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcttacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 28 <211> 4029 <212> DNA <213> S1_Paratyphi_A-2 <400> 28 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa ctcactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg atccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 29 <211> 4029 <212> DNA <213> D13_Typhi-1 <400> 29 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa ctcactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg atccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg taacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 30 <211> 4029 <212> DNA <213> CT18_ Typhi-2_NC_003198 <400> 30 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa ctcactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg atccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg taacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttt tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 31 <211> 4029 <212> DNA <213> S57_Typhi-3 <400> 31 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa ctcactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg atccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg taacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg cataggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accttgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 32 <211> 4029 <212> DNA <213> C21_Blockley <400> 32 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcactcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacatc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtagac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 33 <211> 4029 <212> DNA <213> C3_Litchfield <400> 33 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgatg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta aactgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 gggcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcactcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagaaatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 34 <211> 4029 <212> DNA <213> B20_Stanley <400> 34 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcactcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 35 <211> 4029 <212> DNA <213> B17_Paratyphi_B <400> 35 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cttggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 36 <211> 4029 <212> DNA <213> CVM29188_ Kentucky_NZ_ABAK02000001 <400> 36 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggctgtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacattggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 37 <211> 4029 <212> DNA <213> CDC07_0191_ Tennesee_NZ_ACBF01000033 <400> 37 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 accgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgactc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttattgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 38 <211> 4029 <212> DNA <213> B13_Derby-1 <400> 38 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgactc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtt aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 39 <211> 4029 <212> DNA <213> D1_Enteritidis <400> 39 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agttgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 40 <211> 4029 <212> DNA <213> SP1_Pullorum_ FJ797629 <400> 40 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 tatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agttgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcttgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aggtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggagcc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 41 <211> 4029 <212> DNA <213> SG52_Gallinarum_ FJ797622 <400> 41 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagtg cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agttgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacattg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac caagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcttgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 42 <211> 4029 <212> DNA <213> E6_Weltevreden <400> 42 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagtt ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca accgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagaaatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 43 <211> 4029 <212> DNA <213> C1_Newport-2 <400> 43 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 44 <211> 4029 <212> DNA <213> C22_Newport-3 <400> 44 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgtcctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 45 <211> 4029 <212> DNA <213> D25_Dublin-1 <400> 45 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgct cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaagaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 46 <211> 4029 <212> DNA <213> CT02021853_Dublin-2_ NC_011205 <400> 46 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaagaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 47 <211> 4029 <212> DNA <213> S50_Newport-4 <400> 47 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 48 <211> 4029 <212> DNA <213> SL254_ Newport-5_NC_011080 <400> 48 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggcgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 49 <211> 4029 <212> DNA <213> E3_London-2 <400> 49 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatccg ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 50 <211> 4029 <212> DNA <213> C4_Rissen-1 <400> 50 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggtgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta catccgacgc actacggtcg cgtgtgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcgttg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggag 4020 aacgagtaa 4029 <210> 51 <211> 4029 <212> DNA <213> C10_ Rissen-2 <400> 51 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggtgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta catccgacgc actacggtcg cgtgtgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcgttg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 52 <211> 4029 <212> DNA <213> C19_Hadar <400> 52 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgana ttacgcacaa acgtcgtatc tccgcactcg gcccaggtgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 53 <211> 4029 <212> DNA <213> RKS4594_Paratyphi_C_ NC_012125 <400> 53 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacactac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgttgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagcg 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggagcaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gttggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 54 <211> 4029 <212> DNA <213> C13_Bareilly <400> 54 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tcggaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggggcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgttgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagcg 2580 gcgctctcca aactggatga atccggtatc gtttacctcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttccg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 55 <211> 4029 <212> DNA <213> E1_Senftenberg-1 <400> 55 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgttatgaaa aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgatgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggtgatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctacgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 56 <211> 4029 <212> DNA <213> B16_Paratyphi_B Java <400> 56 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac cattatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtctggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagacctgg taacgtgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgctaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaacgc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 57 <211> 4029 <212> DNA <213> C18_ohio <400> 57 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtcctg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgtatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgtcatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatatac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgagcgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagcg 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggccc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 58 <211> 4029 <212> DNA <213> Javiana_ABEH02000013 <400> 58 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagttgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taatggcaaa 780 gtgtacgttg aaaaaggtcg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta aactgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaaccca 1560 ctgtctgaga ttacgcacaa acgccgtatc tccgcactcg gcccaggtgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtgtgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 59 <211> 4029 <212> DNA <213> S76_London-3 <400> 59 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggtcg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta aactgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcca 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgttggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgatc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 60 <211> 4029 <212> DNA <213> D26_Panama <400> 60 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggtcg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta aactgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttt tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cttggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcg 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcca 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctagggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacattggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgatc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 61 <211> 4029 <212> DNA <213> B18_Muenchen <400> 61 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatttgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtctccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgcgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gtgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacattggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagctcct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgatc tgccgacctc cggtcagatc accctcttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 62 <211> 4029 <212> DNA <213> B19_Schwarzengrund <400> 62 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtttg 1080 agcgcgctgg tagaaatcta tcgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc tggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcg 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcca 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc aactgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctttgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta tcggcgataa gatcaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 63 <211> 4029 <212> DNA <213> B23_Brandenburg <400> 63 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcattctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggtcg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaaccca 1560 ctgtctgaga ttacgcacaa acgccgtatc tccgcactcg gcccaggtgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtgtgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacattggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagctcct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgatc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 64 <211> 4029 <212> DNA <213> C8_Montevideo <400> 64 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agttgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga aattcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggca 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaaccca 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctttgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta tgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggtcgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 65 <211> 4029 <212> DNA <213> E9_Give <400> 65 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tattgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agttgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgtgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggca 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaaccca 1560 ctgtctgaga ttacgcacaa acgccgtatc tccgcactcg gcccaggtgg tctgacccgt 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtgtgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtatccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggt 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta tcggcgataa gatcaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctataccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggc 3900 cgtactaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 66 <211> 4029 <212> DNA <213> C16_Mbandaka <400> 66 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat cccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatt 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggttact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagcg 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggagcaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 67 <211> 4029 <212> DNA <213> S87_Senftenberg-2 <400> 67 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcattctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccacagg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gacatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgt 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggc ctgatcaact ccttgtctgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgttgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggagcaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaactcacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagaaatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 68 <211> 4029 <212> DNA <213> B15_Agona-1 <400> 68 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtggtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcgaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgactcgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgttgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgagtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 69 <211> 4029 <212> DNA <213> SL483_Agona-2_ NC_011149 <400> 69 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtggtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgactcgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgttgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgagtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt aaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tcgacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 70 <211> 4029 <212> DNA <213> B14_Derby-2 <400> 70 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttattgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtggtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccttgtccgt gtacgcacag 1740 actaacgaat atggtttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg tgacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg cgaccaggtt gattacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gactggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaat tgcagatcct tgaagcgggc ctgtttagcc gtatccgtgc ggtacttgtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggagccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacatc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 71 <211> 4029 <212> DNA <213> Heidelberg_SL476_NC_011083 <400> 71 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac tcgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacgggcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagacctgg taacgtgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcatcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaat tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtatccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaat tgcagatcct tgaagcgggc ctgtttagcc gtatccgtgc ggtactggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgag 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgccac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgccaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 72 <211> 4029 <212> DNA <213> SARA23_Saintpaul_ NZ_ABAM02000001 <400> 72 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaaact gcagatggag 720 ctgattccag aacgtctgcg tggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gtaaagtcgt ctctaaagac 900 tacgttgacg aatctactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgacaa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcggg tatcgacatc tataacctga ccaaatacac ccgctctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgtggttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtg 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagttctg cgtctggctg aaaacctgcg taaaggtatg 3540 ccgatcgcaa cgccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaatggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 73 <211> 4029 <212> DNA <213> C12_Virchow <400> 73 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaact gcgtcgttcg atatcgaagc taacggcaag 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcata tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ctctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aagcgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagca 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtcgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gcgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gtgaagcagg tatcgacatc tataacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccgtgc gtatctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgtcc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt aacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcagatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaacttgaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatctc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcaaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt tgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacctc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 74 <211> 4029 <212> DNA <213> B24_Schleissheim <400> 74 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggcctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggcgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg accgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagctgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tatcgaccgt 600 cgccgtaaac tgcctgcgac catcatcctg cgtgcgctga actacaccac tgagcagatc 660 cttgacctgt tctttgagaa agtcgtcttc gaaattcgcg acaacaagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc taacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcagct ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcag gcaaagtcgt ttctaaagac 900 tacgttgacg aatccactgg cgagctgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaactaa cgatcgtctg 1080 agcgcgctgg tagaaatcta ccgcatgatg cgccctggtg agccgccgac acgcgaagcg 1140 gctgaaagcc tgtttgagaa cctgttcttc tccgaagacc gctatgacct gtctgcggtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgtgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acattattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgttgg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgccaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gcttcgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc cggaaggtcc gaacatcggt ctgatcaact ccctgtccgt gtacgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaact acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagatctgg ttacctgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgaccaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gatcccattc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggtgcga acatgcaacg tcaggcggtt ccgactctgc gtgctgataa gccgctggtg 2100 ggtaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt agctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcgtcc cgtatcgtta tcaaagttaa cgaagacgag 2220 atgtacccgg gcgaagcagg tatcgacatc tataacctga ctaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gatgtgctgg cagacggccc gtccaccgac ctcggtgaac tggcgctagg tcagaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg cgatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaagcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 tccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgaccgctg gctggaactc 3000 ggtctgaccg acgaagagaa acaaaatcag ctggaacaac tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa gaaactggaa gcgaagcgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gggttatctc taagatcaac 3240 ccgatcgaag acatgcctta tgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagcacct tcagcgatga tgaagtgctg cgtctggcag aaaacctgcg taaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacttc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tacggcgccg cctacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029 <210> 75 <211> 4029 <212> DNA <213> D11_9,12:l,w:e,n,x <400> 75 atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa 60 gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa gtttatcgag 120 caagatcctg aagggcagta cggtctggaa gcagccttcc gttccgtgtt cccgattcag 180 agctacagcg gtaattccga gctgcagtac gtcagctacc gccttggcga accggtgttt 240 gacgttcagg aatgtcagat ccgtggtgtg acctattccg caccgctgcg cgtaaaactg 300 cgtctggtga tctacgagcg cgaagcgccg gaaggcaccg ttaaagacat taaagaacaa 360 gaagtctaca tgggcgaaat tccgctcatg actgacaacg gtacctttgt tatcaacggt 420 actgagcgtg ttatcgtttc tcagttgcac cgtagtccgg gcgtcttctt tgactccgac 480 aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgcatcat tccttaccgt 540 ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtgcg tattgaccgt 600 cgccgcaaac tgcctgcgac catcattctg cgcgcgctga actataccac tgagcagatt 660 ctggatctgt tctttgaaaa agtagtcttt gagatccgcg acaataagct gcagatggag 720 ctgattccag aacgtctgcg cggcgaaacc gcgtcgttcg atatcgaagc gaacggcaaa 780 gtgtacgttg aaaaaggccg tcgcattacc gcgcgtcaca tccgtcaact ggaaaaagac 840 gatatcaagc atatcgaagt tccggttgag tacatcgcgg gcaaagtcgt ttctaaagac 900 tacgttgacg aatctaccgg cgagttgatc tgcgcggcga acatggagct gagcctggat 960 ctgctggcta agctgagcca gtccggccac aaacgtatcg aaacgctgtt taccaacgat 1020 ctggaccacg gcccgtacat ttctgaaacg gtacgcgtcg acccaaccaa cgatcgtctg 1080 agcgcactgg tagaaatcta ccgtatgatg cgtcctggcg agccgccgac acgcgaagcg 1140 gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gttatgacct gtctgctgtg 1200 ggtcgtatga agttcaaccg ttctctgctg cgcgacgaaa tcgaaggttc cggtatcctg 1260 agcaaagacg acatcattga tgtcatgaag aagctcatcg atatccgtaa cggtaaaggc 1320 gaagtggatg atatcgacca cctcggcaac cgtcgtatcc gttccgtagg cgaaatggcg 1380 gaaaaccagt tccgcgttgg cctggtgcgt gtagagcgtg cggtgaaaga gcgtctgtct 1440 ctgggcgatc tggataccct gatgcctcag gatatgatca acgctaagcc gatttccgcc 1500 gcagtgaaag agttctttgg ttccagccag ctgtctcagt ttatggacca gaacaacccg 1560 ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgc 1620 gaacgcgcag gctttgaagt tcgagacgta cacccgacgc actacggtcg cgtatgtcct 1680 atcgaaacgc ctgaaggtcc gaacatcggt ctgattaact ccctgtccgt gtatgcacag 1740 actaacgaat atggcttcct tgagacgccg taccgtcgtg tggttgatgg cgtggtcact 1800 gacgaaattc attacctgtc tgctatcgaa gaaggcaatt acgttatcgc tcaggcgaac 1860 tccaacctgg atgacgaagg ccactttgta gaagacctgg taacgtgccg tagcaaaggc 1920 gaatccagct tgttcagccg tgatcaggtt gactacatgg acgtttccac ccagcaggtg 1980 gtctccgtcg gtgcgtccct gattccattc ctggaacacg atgacgccaa ccgtgcattg 2040 atgggggcga acatgcaacg tcaggcggtt ccgactctgc gcgctgataa gccgctggta 2100 ggcaccggta tggaacgtgc tgtcgccgtc gactccggtg ttactgcagt ggctaaacgt 2160 ggcggtactg ttcagtacgt ggatgcttcc cgtatcgtta tcaaagttaa cgaaggcgag 2220 atgtacccgg gcgaagcggg tatcgacatc tacaacctga ccaaatacac ccgttctaac 2280 cagaacacct gtatcaacca gatgccatgt gtgtctctgg gcgagccggt tgaacgcggc 2340 gacgtgctgg cggacggtcc gtccaccgac ctcggtgaac tggcgctcgg tcaaaacatg 2400 cgcgtggcgt tcatgccgtg gaacggctac aacttcgaag actccatcct cgtttccgag 2460 cgtgttgttc aggaagaccg tttcaccacc atccatattc aggaactggc gtgcgtgtcc 2520 cgtgacacca agctggggcc ggaagagatc accgctgata tcccgaacgt gggtgaagct 2580 gcgctctcca aactggatga atccggtatc gtttacatcg gcgcggaagt gaccggcggc 2640 gacattctgg tcggtaaggt gacgccgaaa ggtgaaaccc agctgacgcc ggaagagaaa 2700 ctgctgcgtg ctatcttcgg tgagaaagcg tctgacgtta aagactcttc tctgcgcgta 2760 cctaacggtg tctccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa 2820 aaagacaaac gtgctctgga aatcgaagag atgcagctca agcaggcgaa aaaagacctg 2880 tctgaagaac tgcaaatcct cgaggcgggc ctgtttagcc gtatccgtgc ggtgctggtt 2940 gccggcggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggaactc 3000 ggcctgaccg acgaagagaa acaaaatcag ctggaacagc tggctgagca gtatgacgaa 3060 ctgaaacacg agttcgagaa aaaactcgaa gcgaaacgcc gtaaaatcac ccagggcgac 3120 gatctggcgc cgggcgtgct gaagatcgtg aaggtctatc tggccgttaa acgccgtatc 3180 cagccgggtg ataagatggc aggtcgtcac ggtaacaagg gtgttatttc taagatcaac 3240 ccgatcgaag acatgcctta cgatgaaaac ggcacgccgg tagacatcgt actgaacccg 3300 ctgggcgtac cgtctcgtat gaacatcggt cagattctgg aaacccacct gggtatggct 3360 gcgaaaggta ttggcgacaa gattaacgcc atgctgaaac agcagcagga agtcgcgaaa 3420 ctgcgcgaat tcatccagcg tgcctacgat ctgggcgccg acgttcgtca gaaagtcgac 3480 ctgagtacct tcagtgatga tgaagtgttg cgtctggcag aaaacctgcg caaaggtatg 3540 ccgattgcca caccagtgtt cgacggtgcg aaagaagcgg aaatcaaaga gctgctgaaa 3600 ctgggcgacc tgccgacttc cggtcagatc accctgttcg atggccgtac gggtgaacag 3660 ttcgaacgtc cggtaaccgt cggttacatg tacatgctga aactgaacca cctggttgat 3720 gacaagatgc atgcgcgttc taccggttct tacagcctgg ttactcagca gccgctgggt 3780 ggtaaggcgc agttcggtgg tcagcgcttc ggggagatgg aagtgtgggc gctggaagct 3840 tatggcgccg cctacaccct gcaagaaatg ctcaccgtta agtctgatga cgtcaacggt 3900 cgtaccaaga tgtataagaa catcgtggac ggcaaccatc agatggaacc gggtatgccg 3960 gaatccttca acgttctgtt gaaagagatc cgctcgctgg gcatcaacat cgaactggaa 4020 gacgagtaa 4029

Claims (18)

  1. 삭제
  2. (1) 서열번호 1 및 서열번호 2 의 염기서열로 이루어진 프라이머 쌍을 사용하여 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을 증폭하는 단계;
    (2) 서열번호 5, 서열번호 6, 및 서열번호 10 내지 서열번호 14의 염기서열로 이루어진 프라이머를 사용하여, 상기 단계 (1)에서 증폭된 rpoB 유전자의 전체 염기서열을 결정하는 단계;
    (3) 상기 단계 (2)에서 얻어진 염기서열을, 서열번호 15 내지 서열번호 75의 염기서열로 이루어진, 표준 균주의 rpoB 유전자의 염기서열과 비교하여 혈청형을 결정하는 단계를 포함하는,
    살모넬라 속 미생물의 혈청형을 동정하는 방법.
  3. 삭제
  4. 삭제
  5. 삭제
  6. 삭제
  7. 제2항에 있어서, 상기 단계 (3) 은 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열을, 서열번호 15 내지 서열번호 75의 염기서열로 이루어진, 표준 균주의 rpoB 유전자의 염기서열에 대입하여 다중배열한 후 계통도를 완성하여 결정하는 것인 방법.
  8. 삭제
  9. 서열번호 1 및 서열번호 2의 염기서열로 이루어진, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 증폭용 프라이머 쌍.
  10. 서열번호 5, 서열번호 6, 및 서열번호 10 내지 서열번호 14의 염기서열로 이루어진, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 결정용 프라이머.
  11. 삭제
  12. (i) 서열번호 1 및 서열번호 2의 염기서열로 이루어진, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 증폭용 프라이머 쌍, (ii) 서열번호 5, 서열번호 6, 및 서열번호 10 내지 서열번호 14의 염기서열로 이루어진, 살모넬라 속 미생물의 rpoB 유전자의 전체 염기서열 결정용 프라이머, 및 (iii) 서열번호 15 내지 서열번호 75의 염기서열로 이루어진, 표준 균주의 rpoB 유전자
    를 포함하는 살모넬라 속 미생물의 혈청형 동정용 조성물.
  13. 삭제
  14. 삭제
  15. 제12항의 조성물을 포함하는 살모넬라 속 미생물의 혈청형 동정용 키트.
  16. 제15항에 있어서, 상기 키트는 PCR-RFLP (restriction fragment length polymorphism) 키트, allele-specific PCR 키트, 실시간 PCR 키트, DNA 칩 키트 또는 서던 블랏팅 키트인 살모넬라 속 미생물의 혈청형 동정용 키트.
  17. 삭제
  18. 서열번호 15, 서열번호 16, 서열번호 17, 서열번호 19, 서열번호 20, 서열번호 21, 서열번호 22, 서열번호 24, 서열번호 25, 서열번호 26, 서열번호 28, 서열번호 31, 서열번호 32, 서열번호 33, 서열번호 34, 서열번호 38, 서열번호 43, 서열번호 44, 서열번호 45, 서열번호 47, 서열번호 49, 서열번호 50, 서열번호 51, 서열번호 54, 서열번호 55, 서열번호 56, 서열번호 57, 서열번호 59, 서열번호 60, 서열번호 61, 서열번호 63, 서열번호 64, 서열번호 65, 서열번호 66, 서열번호 67, 서열번호 68, 서열번호 70, 서열번호 74 및 서열번호 75의 염기서열로 이루어진 군으로부터 선택되는 염기서열로 이루어진 살모넬라 속 미생물의 rpoB 폴리뉴클레오티드.
KR1020110144486A 2011-12-28 2011-12-28 살모넬라 혈청형의 분자적 동정을 위한 프라이머 및 이를 이용한 살모넬라 혈청형 동정 방법 KR101412120B1 (ko)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102411940B1 (ko) 2021-12-17 2022-06-22 대한민국 살모넬라 종 판별용 프로브 조성물 및 이를 포함하는 살모넬라 종 판별용 키트
KR102618075B1 (ko) 2023-02-22 2023-12-29 대한민국 올리고뉴클레오티드 세트를 포함하는 사료의 살모넬라 d 그룹 신속 검출용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gene, Vol. 165, No. 1, Pages 1-8 (1995.11.07.) *
Vet Microbiol., Vol. 82, No. 2, Pages 121-129 (2001.09.20.) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102411940B1 (ko) 2021-12-17 2022-06-22 대한민국 살모넬라 종 판별용 프로브 조성물 및 이를 포함하는 살모넬라 종 판별용 키트
KR102618075B1 (ko) 2023-02-22 2023-12-29 대한민국 올리고뉴클레오티드 세트를 포함하는 사료의 살모넬라 d 그룹 신속 검출용 조성물

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