KR101395823B1 - Method of anticancer treatment using ultrasonicwave and apparatus for anticancer treatment using ultrasonicwave - Google Patents

Abstract

An anti-cancer treatment method and an anti-cancer treatment apparatus using an ultrasonic interference phenomenon for killing cancer cells using mechanical vibration of an ultrasonic wave are disclosed. The imaging medical apparatus includes a target object information extracting unit for obtaining a three-dimensional image of a target object and extracting anatomical information of the target object and information of cancer cells of the target object, and a plurality of ultrasound generating units for generating ultrasound in cancer cells of the target based on the extracted information of the cancer cells. And an ultrasonic generator including an ultrasonic generator. Therefore, only cancer cells can be killed by target without loss of normal cells of the subject.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to an ultrasound-

The present invention relates to an anticancer therapy method and an anticancer therapy apparatus, and more particularly, to an anticancer therapy method and an anticancer therapy apparatus using ultrasound.

Cancer cells are mutant cells and have different characteristics from normal cells. The shape and size of cancer cells are somewhat changed compared to normal cells. Cancer cells have more chromosomes than normal cells, have a larger proportion of nuclei to protoplasts than normal cells, and often have fission bodies with nuclear bodies. This characteristic is called a dysplasia, and a strong dysplasia is characteristic of a cancer cell.

Another difference between cancer cells and normal cells is that, unlike normal cells, cancer cells have a nucleus with a large nucleus and a distinct nucleus, which causes the cancer cells to grow without causing cell division. This continuous growth causes cancer cells to destroy or erode normal cells by pushing or piercing normal tissues around cancer cells.

In addition, cancer cells have weaker heat characteristics than normal cells. Cancer cells are weak against heat and die at about 43.5 ℃. There are a lot of capillaries formed around the tumor, but the nutrients are not properly supplied because of congestion.

According to "Nanomechanical analysis of cells from cancer patients" (Nature biotechnology published online, 02 December 2007), the cell structure of malignant tumor tissue is unstable compared to normal tissue, and the elasticity of cell membrane constituting cell is very high There are differences. (E = 0.53 ± 0.10 kPa) was much smoother than normal cells (E = 1.97 ± 0.70 kPa) by measuring the elastic modulus (E) of the cell membrane using an atomic force microscope (AFM) . In other words, although the shape of the metastatic cancer cell is very similar to that of the normal cell, the elasticity is so excellent that it can be easily distinguished.

If the difference between the above-described cancer cells and normal cells can be utilized, it is possible to utilize the characteristics possessed by cancer cells only to minimize the damage to the normal cells of the subject during chemotherapy and to develop a chemotherapeutic and chemotherapeutic device You can help.

Chemotherapy can be classified into local treatment methods that focus only on local areas where cancer cells are present, and systemic treatment methods that target the whole body of a subject. As a local treatment method, there are a typical method of extracting cancer cells from the human body using surgical operation and a method of using radiation having high energy as a radiation treatment. Unlike topical treatments such as surgery or radiation therapy, medication is systemic chemotherapy with anticancer drugs.

The aforementioned chemotherapeutic treatment methods are not performed individually, but most of the chemotherapeutic treatments are performed in parallel with surgery, radiation, and medication. Among them, chemotherapy using surgical surgery is a cancer treatment method which is preferentially applied to medication or radiation therapy in cancer treatment. Currently, surgical techniques have been developed to remove only cancer cells using a robot-based surgical apparatus, or to perform surgical operations using a gamma knife in the case of pituitary tumor metastatic brain tumors, which are difficult to perform surgically.

Other chemotherapy methods include drug therapy using anticancer drugs. Anticancer drugs are drugs that use the properties of rapidly dividing cancer cells to prevent cell division. Medication has the disadvantage that it can attack normal dividing cells as well. In order to overcome the limitations of this drug therapy, researches on Targeted Chemotherapeutic Agent for selecting and killing cancer cells are currently underway. A signal transduction inhibitor that inhibits signal transduction pathways involved in the production and proliferation of cancer cells, an angiogenesis inhibitor that blocks new angiogenesis that cancer cells require to grow beyond a certain size, A new apoptosis inhibitor that induces the cell death by inducing a predetermined cell apoptosis of cancer cells is a representative target anticancer drug for distinguishing only cancer cells from normal cells and killing them.

Radiation therapy, another method of chemotherapy, is an anticancer treatment method that treats only areas where cancer cells are locally present, like surgery. It is an anti-cancer treatment method that can kill cancer cells by passing high-energy X-ray or electron beam made by using a linear accelerator to a tumor inside the patient's body and can be painlessly performed within a short time compared with surgery. Currently, Image Guided Radiotherapy (IGRT), which can compare images of tumors in the body three-dimensionally before and after treatment, is developed by adding imaging functions such as CT, MRI and PET to radiotherapy devices Has been used.

Typically, a tomotherapy device (Tomotherapy) that combines a radiotherapy device using a high-energy x-ray and a computerized tomography (CT) capable of computed tomography (CT) confirms the three-dimensional position of the tumor in a cancer patient, Or less of the radiation can be irradiated while rotating 360 degrees. The biggest advantage of tomothecopy is that it has a built-in CT to check the size of the cancer every day. In addition, it treats several scattered cancer masses at once, regardless of the size, shape, and number of tumors, and provides the CT screen in real time through connection with the computer system to determine the exact location of the tumor distributed to the patient, It is operated in such a way that the radiation is effectively intensively examined. When the cancer is scattered or spread widely, it is divided into several treatments, but tomotherapy can be treated at one time and the side effects of radiation therapy can be reduced.

As a method for chemotherapy except for the above-mentioned typical chemotherapy, there is a method of treating cancer using high intensity focused ultrasound (HIFU) using the characteristic that cancer cells are weak to heat. In Korean Patent Laid-Open No. 2001-0040408 ("High-intensity Focusing Ultrasonic System for Tumor Stanning and Therapy"), a combination sensor, a power source, a B-ultrasonic generator, a multidimensional digital control mobile device, a vacuum dehydrator, A high-intensity focal-point ultrasound-based chemotherapy apparatus is disclosed.

In Korean Patent Laid-Open Publication No. 2001-0040408, the coupling sensor is composed of a B-ultrasonic sensor, an ultrasonic wave generation sensor, and an ultrasonic wave generation generating end. The moving device is a device for performing a scanning movement on a human body under computer control Device is disclosed. Therefore, the high-intensity focal ultrasound (HIHF) generated in the human body by the movement and scanning of the therapeutic sensor causes the tissue cavity to cavitate and generate waves, and the temperature in this area instantaneously rises to 70 ° C, A high-intensity focal-point ultrasound-based chemotherapy apparatus is disclosed which is capable of necrosing a sphere.

One of the conventional methods of chemotherapy is surgery, but only local areas where cancer cells are present are removed, but no cancer cells should be left to prevent recurrence of cancer cells. Therefore, inevitably, normal tissues around the cancer cells are removed. As a side effect of cancer surgery, complications, organ damage, and nerve tissue damage are unlikely to lead to the same normal life as before the onset of cancer.

Other chemotherapy regimens have a higher rate of recurrence of cancer than surgical operations and their use is limited to some cancers. In addition, it inhibits the division of cancer cells of anticancer drugs, and thus prevents the division of normal cells. Therefore, it has side effects of destroying normal hair cells, white blood cells, reproductive cells, .

Radiation therapy, which is another chemotherapeutic therapy, can cause complications due to the carcinogenesis of normal cells around cancer cells due to radiation. Also, side effects caused by continuous exposure to radiation are problematic.

에 이르러 정상세포에 필연적인 손상을 가지고 올 수 밖에 없다. 또한 대상체가 가진 종양의 위치에 따라 다양한 각도에서 초음파를 발생시킬 수 없어 대상체의 종양세포의 위치에 따라 정확하게 파동을 발생시킬 수 없다. 또한 한국공개특허 제2001-0040408호에 따르면 하나의 초음파 발생기를 사용하여 초음파를 발생시키는 구조에 있어 정확하게 대상체가 가진 조직이나 구조의 고유특성에 맞게 초음파를 발생시켜 정확한 항암치료효과를 얻기에는 무리가 있다. In addition, the high-intensity focal ultrasound (HIFU)

It is inevitable to come to the normal cell with the necessary damage. In addition, ultrasonic waves can not be generated at various angles depending on the location of the tumor, so that the wave can not be accurately generated depending on the location of the tumor cells. Korean Patent Laid-Open No. 2001-0040408 discloses that, in the structure for generating an ultrasonic wave by using a single ultrasonic generator, it is difficult to accurately obtain the effect of the anti-cancer therapy by generating ultrasonic waves in accordance with the inherent characteristics of the tissue or structure of the object have.

Accordingly, it is a first object of the present invention to provide an anticancer treatment method for effectively killing cancer cells while minimizing adverse effects of chemotherapy by minimizing damage to normal cells during chemotherapy.

It is also a second object of the present invention to provide an anticancer treatment apparatus that implements the above-mentioned anticancer treatment method.

According to an aspect of the present invention, there is provided an image medical apparatus for acquiring an anatomical information of a target object and cancer cell information of the target object by acquiring a three- An information extracting unit, and an ultrasonic generator including a plurality of ultrasonic generators for generating ultrasonic waves on cancer cells of the subject based on the information on the extracted cancer cells. The object information extracting unit may include an image forming unit operable to form a three-dimensional image of the object, an object analyzing unit extracting anatomical information of the object from the formed three-dimensional image, information on the cancer cells of the object from the formed three- And a tumor extracting unit that operates to extract the tumor. The image medical apparatus performs simulation based on the information of the target object collected by the target information extracting unit so that the plurality of ultrasound generators generate ultrasonic waves at the positions of the cancer cells of the target object to cause an interference phenomenon, And a simulation unit that can perform the simulation. , The image medical apparatus includes a user interface for inputting a command for controlling the operation of the image medical apparatus, a target object information extracting unit included in the image medical apparatus, the ultrasonic generator, the simulation unit, And a control unit for controlling the display unit. The plurality of ultrasound generators may generate ultrasound waves so that ultrasound waves generated by the plurality of ultrasound generators may interfere with each other based on information of the target object collected by the target object information extracting unit. The plurality of ultrasound generators may include at least one combination of a plurality of ultrasound generators facing each other to be included in the imaging medical device. The plurality of ultrasound generators may be arranged in a circular shape along the girth of the imaging medical device. The positions of the plurality of ultrasonic generators can be freely moved without being fixed to adjust the position of the ultrasonic waves generated according to the cancer cell position of the object. The range of wavelengths generated by the plurality of ultrasonic generators may have a frequency of 23 kHz or less in the cancer cells of the subject.

According to another aspect of the present invention, there is provided a method of using a medical imaging apparatus, comprising: acquiring a three-dimensional image of a target object; obtaining anatomical information of the target object; And generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells. The step of acquiring the three-dimensional image of the object and extracting the anatomical information of the object and the information of the cancer cells of the object includes forming a three-dimensional image of the object, Extracting information on the cancer cells of the object from the formed three-dimensional image. A method of treatment using an image medical device includes performing a simulation based on information obtained from anatomical information of the target object and cancer cell information of the target object by acquiring a three-dimensional image of the target object, And generating a plurality of ultrasound waves at a position of the ultrasound echo signal to generate an interference phenomenon. A method of using an image medical apparatus includes inputting a command for controlling an operation of the image medical apparatus, acquiring an anatomical information of the object and information of cancer cells of the object by acquiring a three-dimensional image of the object A step of generating a plurality of ultrasonic waves in cancer cells of the subject based on the information of the cancer cells, a step of simulating in advance so as to generate a plurality of ultrasonic waves at the position of the cancer cells of the subject and causing an interference phenomenon, And further comprising the step of controlling the step of inputting a command for controlling the operation of the apparatus. The step of generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells may include extracting anatomical information of the subject and information of cancer cells of the subject by acquiring a three- The ultrasonic waves may be generated so that the plurality of ultrasonic waves may cause interference at the cancer cell position of the object based on the information of the object. The step of generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells may cause the plurality of ultrasonic waves to occur on the same line so that the plurality of ultrasonic waves may cause interference. The step of generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells may include generating a plurality of ultrasonic waves in the form of a circular gantry to generate ultrasonic waves in accordance with the position of the cancer cells of the subject . Wherein the step of generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells comprises the steps of generating a plurality of ultrasonic waves by the ultrasonic generator for generating the plurality of ultrasonic waves without being fixed so as to adjust the position of the ultrasonic waves generated according to the cancer cell position of the subject, So that ultrasound can be generated according to the position of the cancer cells of the target. The step of generating a plurality of ultrasonic waves in the cancer cells of the subject based on the information of the cancer cells may have a frequency of 23 kHz or less in the cancer cells of the subject.

As described above, according to the anti-cancer treatment method and the anti-cancer treatment apparatus using the ultrasound according to the embodiment of the present invention, the position of the cancer cells accurately possessed by the object can be grasped by using the image medical apparatus, It is possible to kill cancer cells by using the interference phenomenon of transmitted ultrasound waves by transmitting ultrasound waves generated from a plurality of ultrasound generators.

Therefore, by using the wave interference phenomenon, only the cancer cells can be accurately targeted and killed, thereby reducing the damage to the normal tissues. Thus, it is possible to solve various side effects of the chemotherapy.

FIG. 1 illustrates an image medical apparatus for killing cancer cells in a subject using ultrasound according to an embodiment of the present invention. Referring to FIG.
2 is a flowchart illustrating a method for killing cancer cells in a subject using ultrasound according to an embodiment of the present invention.
FIG. 3 is a block diagram showing various components of an image medical apparatus for killing cancer cells in a subject using ultrasound according to an embodiment of the present invention. Referring to FIG.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It should be understood, however, that the invention is not intended to be limited to the particular embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing.

The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component. And / or < / RTI > includes any combination of a plurality of related listed items or any of a plurality of related listed items.

It is to be understood that when an element is referred to as being "connected" or "connected" to another element, it may be directly connected or connected to the other element, . On the other hand, when an element is referred to as being "directly connected" or "directly connected" to another element, it should be understood that there are no other elements in between.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the terms "comprises" or "having" and the like are used to specify that there is a feature, a number, a step, an operation, an element, a component or a combination thereof described in the specification, But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Hereinafter, the same reference numerals will be used for the same constituent elements in the drawings, and redundant explanations for the same constituent elements will be omitted.

When two waves propagate in one medium and overlap, there are weak and strong waves. Constructive Interference is a composite displacement that is caused by superimposing the floor and the floor of two waves or the bone and the bone in the same phase. It is called maximum constructive interference when the amplitude of the composite wave is maximized because the phases of the two waves are the same. Destructive Interference is the result of superimposing the floor and the valleys of two waves and reducing the composite displacement. When the phase difference of the two waves is π / 2, the amplitude of the composite wave is minimized and this is called maximum destructive interference.

An embodiment of the present invention relates to a method of performing chemotherapy using the phenomenon of interference of waves. Currently, imaging such as magnetic resonance imaging (MRI), magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET) With the development of medical devices, it is possible to accurately grasp the position and size of cancer cells in the tissues inside the human body by utilizing such image medical devices. The imaging device includes a device capable of generating a wave, and using the wave interference phenomenon generated when generating multiple waves in a cancer cell, a strong vibration is exerted only on the cancer cell while giving a minimal damage to the normal cells around the cancer cell Cancer cells can be killed.

1 is an image medical device according to an embodiment of the present invention. The image medical apparatus 100 may include a gantry 120, a gantry driving unit 121, a test strip 140, a test strip driving unit 142, an ultrasonic generator 150, and a controller 160.

The gantry 120 is an apparatus for acquiring an image of a target object in an imaging medical device, and includes an X-ray tube for generating an X-ray for obtaining an image of a target object, And may include an apparatus capable of generating an electromagnetic signal. Also, the gantry 120 may include a collimator that can control the intensity of radiation, which depends on the type of the imaging medical device but can control the intensity of the radiation, which is a part for acquiring the image of the object, a detector that can receive the radiation signal and convert it into an electrical signal, And a device capable of converting a signal to a digital signal.

The gantry driving means 121 is for allowing the gantry to move in order to drive the gantry 120 for obtaining the image of the object. The gantry drive means 121 can form a three-dimensional image of the object while rotating the gantry 120 around the object located at the inspection table 140 at a certain angle. The gantry drive means 121 can rotate the gantry 120 on the basis of a constant rotation axis in accordance with a photographing purpose of the object and can drive the gantry 120 with a constant speed or a change in speed when rotating.

The gantry drive means 121 may be moved by receiving a command from the controller 160 and the movement of the ultrasonic wave generator 150 included in the gantry 120 may be controlled by a gantry 120, but the means for controlling the movement of the ultrasonic generator 150 is not limited thereto, and it is also possible to control the ultrasonic generator 150 by means of the gantry drive means 121.

The inspection table 140 may be formed at regular intervals from the gantry 120 and may have a constant width and size to allow the object to be laid down. And a fixing device capable of fixing the object. The width and size of the inspection table 140 may be variously determined according to the size of the gantry 120 and the fixing device included in the inspection table 140 may be configured of various members capable of fixing the object.

The test strip driving means 142 can move in the front-back direction or the left-to-right direction so that the test strip 140 can be positioned at the center portion inside the gantry 120. If necessary, the examination table 140 may be rotated so that the examination table 140 is rotated. The inspection unit driving means 142 may move the inspection unit 140 based on a command received from the control unit 160. [

At least two ultrasonic generators 150 may be included in the gantry 120 and two ultrasonic generators 150 facing each other in the gantry may be positioned to face each other at an angle of 180 degrees. Also, the ultrasound generator 150 may be installed to move freely within the gantry 120 to generate ultrasound for the treatment of the patient. The two ultrasonic generators 150 facing each other are located outside the body of the object (for example, the patient) so that the two ultrasonic generators 150 face each other at an angle of 180 degrees, so that the ultrasonic waves can be generated to the object at various angles.

Further, the ultrasonic generator 150 can generate ultrasonic waves in the cancer cells of the object. According to one embodiment of the present invention, the difference between the cancer cells and the normal cells is different from that of the normal cells. In order to kill cancer cells only by subjecting the cancer cells to mechanical vibration, Can be used. The ultrasonic waves generated from the respective ultrasonic generators 150 cause interference phenomenon in the vicinity of the cancer cell tissue to generate resonance vibration in the vicinity of the cancer cell so that the amplitude of the ultrasonic waves exceeds the cell membrane elasticity limit of the cancer cell, . By continuously generating ultrasonic waves that exceed the elastic limit of the cell membrane, the mechanical vibration of the ultrasonic waves can be continuously transmitted to the cancer cells. Through this process, cancer cells can be destroyed by destroying the cell membrane of cancer cells. That is, the ultrasonic waves generated from the plurality of ultrasonic generators 150 may cause mechanical vibrations due to the interference phenomenon, and only the cancer cells can be selectively killed by using such vibrations.

Since the ultrasonic wave generated by the ultrasonic generator 150 is less responsive to the continuous stimulus than the intermittent stimulus of the nerve tissue (USSR Inventor's Certificate 649, 429, A 61 H 23/00, 1979), the output from each ultrasonic generator The ultrasonic wave can be controlled to have a continuous shape, and the period and shape in which the ultrasonic wave is generated can be adjusted as needed.

The main range of the frequency of the waves generated in the ultrasonic generator 150 is 23-27 kHz in the mechanical vibration of the healthy cell membrane in the majority of the vertical tissues (Korean Patent Publication No. 2003-0055245, " Considering the fact that the mechanical vibration frequency of the cell membrane is in the range of 23 kHz to 27 kHz in the case of normal cells, when the ultrasonic waves generated in the respective ultrasonic wave generators cause interference phenomenon in the tumor tissue of the object, So that only the cancer cells can be killed by the target and the damage to the normal cells can be reduced.

The ultrasonic generator 150 may be implemented using an ultrasonic transducer. The ultrasonic transducer can utilize the sound waves generated when the object vibrates. It is possible to implement an ultrasonic generator included in the imaging medical device 100 by using an apparatus for generating an ultrasonic wave such as a magnetostrictive vibrator in which an electric field is applied and a distortion is generated when an electrostriction oscillator using a piezoelectric effect or a magnetic field is applied.

The amplitude, frequency, and phase of the ultrasonic waves generated in the ultrasonic generator 150 may vary depending on the impedance value, which is the resistance of the medium with respect to the waves of the tissue of the object. Therefore, it is possible to analyze the refraction, attenuation, and reflection phenomenon of a sound wave, which may occur during the course of the ultrasound to the cancer cells through the tissue of the object, based on the three-dimensional image of the object obtained through the gantry 120.

That is, by controlling the frequency, phase, and intensity of the ultrasonic waves generated from the respective ultrasonic transducers 150, ultrasonic waves of the same frequency are superimposed near the cancer cell tissue to generate resonance vibration in the vicinity of the cancer cells, The ultrasonic wave of the ultrasonic wave continues to be transmitted to the cancer cells by making the ultrasonic wave exceed the elastic limit of the tissue cell membrane and continuously generating the ultrasonic wave of the size exceeding the elastic limit of the cancer tissue membrane. Through such a series of processes, cancer cells can be killed by destroying the cell membrane of cancer cells.

1, the ultrasonic generators 150 may be disposed along a predetermined circumferential surface of the gantry 120 so that the positions of the ultrasonic generators 150 can be controlled, Thereby enabling more accurate and effective cancer treatment.

The frequency and the amplitude phase of the ultrasonic waves generated by the respective ultrasonic wave generators 150 and the position where the ultrasonic waves are generated can be adjusted differently according to the tissue information inherent to the object. The imaging medical device 100 may further include a device capable of simulating whether a plurality of ultrasound waves generated from the ultrasound generator 150 reach the position of the tumor of the target object to cause an interference phenomenon. 150 may be performed through simulation based on the three-dimensional information of the object obtained in the image medical device 100.

2 is a flowchart illustrating a method of killing cancer cells using an ultrasonic wave interference phenomenon generated in a plurality of ultrasonic generators according to an embodiment of the present invention.

Referring to FIG. 2, the database of the cancer cell information and the anatomical characteristics of the target object, such as the location and size of the cancer cell, is collected and used as a three-dimensional image, The basic information is collected and a three-dimensional image of the object is formed (step 210). Based on the three-dimensional image of the object formed by the imaging medical device, information on the chemical or physical state of the internal tissue such as the organ or bone of the object, and structural information, which is information on the external structure constituting the object (Step 220). In addition, tumor information of a target object, which is information on the position, type, size, and the like of the target tumor, is extracted (step 230). The information collected by the imaging medical device is not limited thereto, but information other than the information necessary for the treatment of the object may be collected.

The method may further include a step of performing a simulation to generate a wave at a location of a cancer cell of the object based on the information collected using the imaging device (step 240). Simulations can be performed to minimize damage to normal cells and to selectively kill cancer cells when the waves cause mechanical vibrations by causing interference at the tumor site.

The simulation can be carried out based on the information on the structure of the tissue of the object such as the organs, bones, and blood vessels possessed by the object obtained through the imaging medical device, the structure information of the object, and information on the tumor of the object. Even if the ultrasonic wave having the same frequency and amplitude is passed through the object, the properties of the ultrasonic wave may be changed due to the reflection interference diffraction phenomenon at the arrival point of the ultrasonic wave. Therefore, the amplitude, phase and frequency It is possible to determine in advance by simulation whether the ultrasonic waves generated by the respective ultrasonic generators can cause interference phenomena in the position of the tumor of the object.

The ultrasound waves may be generated in the respective ultrasound generators based on information such as the phase amplitude frequency of each ultrasound to be generated at the location of the cancer cells determined by the simulation (step 250). Each ultrasonic generator moves freely within the gantry based on the information obtained through the simulation, and can move to a position where it can effectively generate waves on the cancer cells of the object. In order to effectively kill cancer cells, the position of the object can also be changed using the ultrasonic generator as well as the position of the ultrasonic generator. When an external command is issued when an instruction to generate an ultrasonic wave is issued, the ultrasonic wave may be controlled to generate an ultrasonic wave in accordance with an external command in preference to the simulation generated wave generation information.

3 is a schematic block diagram of an imaging medical device according to an embodiment of the present invention.

3, the image medical apparatus includes an image forming unit 310, an object analyzing unit 320, a tumor extracting unit 330, an ultrasonic wave generating unit 340, a simulation unit 350, a user interface 360, And a control unit 370. [0035]

The image forming unit 310 is for forming an image of a target object and may be implemented differently according to an image medical apparatus. For example, an imaging medical device, such as a CT (Computerized Tomography) imaging device, can generate X-rays to obtain a cross-sectional image of an object cut horizontally. Another example of an imaging medical device is an MRI (Magnetic Resonance Imaging), which transfers a high frequency in a magnetic field to form an image of the object. Accordingly, the image forming unit 310 may be implemented differently according to each image medical device.

The object analyzing unit 320 analyzes the information about the position, the constitution, the characteristic, and the like of the object, which the object has, based on the image information provided from the image forming unit 310, in detail. The biometric information inherent to the tissue of the subject can be analyzed through the subject analysis unit 320. [ The functions of the object analyzing unit 320 may be included in the image forming unit 310 and may be performed together. The object analyzing unit 320 may be provided in the image medical apparatus as separate blocks as shown in FIG. It is possible to simulate the depth, frequency, phase, amplitude, and the like of the ultrasonic waves to be reached when a plurality of ultrasonic waves are generated in the object based on the information of the object.

The tumor extracting unit 330 extracts information on the position, size, and shape of the tumor of the subject based on the analyzed information of the object through the image forming unit 310 and the object analyzing unit 320. The tumor extracting unit 330 may be implemented as a separate block as shown in FIG. 3 or may be included in the image forming unit 310. The information of the tumor of the object can be used for the treatment of other objects as well as it can be used for the treatment of the object in a database.

Not only the information of the object obtained by the tumor extracting unit 330 but also the information of the object obtained by the image forming unit 310 and the object analyzing unit 320 can be stored in the database and used again for the treatment of the object It can also be used to treat other subjects.

As described above, the image forming unit 310, the object analyzing unit 320, and the tumor extracting unit 330 can be configured as one part in the image medical apparatus. In this case, the image forming unit 310, the object analyzing unit 320, and the tumor extracting unit 330 may be embodied as a target information extracting unit 300 for collectively extracting object information.

The ultrasound generator 340 may include a plurality of ultrasound generators. The ultrasound generator 340 controls the ultrasound generators 340 and 340 to move the ultrasound generators to a position suitable for the treatment of the tumor based on the information of the target object obtained from the image forming unit 310, the object analyzing unit 320, can do. It is possible to control information such as phase, amplitude, and frequency of a wave to be generated in each ultrasonic generator. The controller 370 can control the position of the ultrasonic generator, and the control of the phase, amplitude, and frequency of the ultrasonic wave generated by each ultrasonic generator.

The simulation unit 350 generates the ultrasound image based on information obtained based on the information of the object obtained from the image forming unit 310, the object analyzing unit 320 and the tumor extracting unit 330, It is possible to simulate the phenomenon of reaching tumor cells with mutual interference. These simulations can allow normal cells of the subject to be damaged without causing damage to the tumor cells of the subject. The simulation unit 350 may generate a wave on the object immediately without performing a simulation when an external command is issued by the user interface 360 as a part for more accurately correcting only cancer cells as a target.

The user interface 360 may forward an external command to the imaging medical device or may transfer the information generated from the imaging medical device to the outside. The ultrasonic wave generator 340 generates ultrasonic waves based on the information of the object obtained from the image forming unit 310, the object analyzing unit 320, and the tumor extracting unit 330 of the imaging medical device through the user interface 360 The target object can be treated by preferentially forwarding an external command. The operation of the image forming unit 310, the object analyzing unit 320, and the tumor extracting unit 330 may be controlled by controlling the degree of treatment of the upper body tumor cells based on an external command transmitted through the user interface 360 Can be controlled.

The control unit 370 may control the respective parts to operate by using a procedure stored in advance based on the information received from the respective parts of the image medical apparatus, So that each part of the device can be operated.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, This is possible.

310: Image forming unit 320:
330: tumor extracting unit 340: ultrasonic wave generator
350: Simulation part 360: User interface
370:

Claims (18)

In an imaging medical device,
An object information extracting unit for acquiring an anatomical information of the object and information of cancer cells of the object by acquiring a three-dimensional image of the object; And
And an ultrasonic generator including a plurality of ultrasonic generators for generating ultrasonic waves on cancer cells of the subject based on the information of the extracted cancer cells,
Adjusting at least one of a frequency, a phase, and a vibration intensity of ultrasonic waves generated in the plurality of ultrasonic generators according to the information of the extracted cancer cells,
Wherein the ultrasound waves cause the resonance vibration to occur so that the ultrasonic amplitude exceeds the elastic limit of the elastic membrane of the cancer cell and the ultrasonic wave exceeding the elastic limit is transmitted until the cell membrane of the cancer cell is destroyed, Medical device. The information processing apparatus according to claim 1,
An image forming unit operable to form a three-dimensional image of the object;
An object analyzer for extracting anatomical information of a target object from the formed three-dimensional image; And
And a tumor extracting unit operable to extract cancer cell information of the object from the formed three-dimensional image. The medical imaging apparatus according to claim 1,
A simulation unit that performs a simulation based on the information of the object collected by the object information extracting unit so that the plurality of ultrasonic generators generate ultrasonic waves at a position of a cancer cell of the object to cause an interference phenomenon; Further imaging medical devices. 4. The apparatus of claim 3, wherein the imaging medical device
A user interface for inputting a command for controlling the operation of the imaging medical device; And
Further comprising a controller for controlling operations of the object information extracting unit, the ultrasonic generator, the simulation unit, and the user interface included in the image medical apparatus. delete The ultrasonic diagnostic apparatus according to claim 1,
Wherein at least one combination of the plurality of ultrasonic generators facing each other is formed and included in the imaging medical device. The ultrasonic diagnostic apparatus according to claim 1,
Wherein the imaging device is arranged in a circular shape along the periphery of the gantry of the imaging medical device. The ultrasonic diagnostic apparatus according to claim 1,
Wherein the ultrasound diagnostic apparatus is capable of moving freely without being fixed so as to adjust a position of an ultrasonic wave generated according to a cancer cell position of the target object. The ultrasonic diagnostic apparatus according to claim 1, wherein the range of the wavelengths generated by the plurality of ultrasonic generators
So that the cancer cell of the subject can have a frequency of 23 kHz or less. delete delete delete delete delete delete delete delete delete

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