KR101371188B1 - Food Composition for Improving Constipation - Google Patents

Abstract

The present invention discloses a food composition for improving constipation. Specifically, the present invention discloses a food composition for improving constipation comprising a protease-treated powder of horse placenta as an active ingredient. Food composition for improving constipation of the present invention may further comprise Hallabong fruit powder in order to neutralize the specific odor of the proteolytic enzyme treatment powder of horse placenta, cha-chae powder and fermented brown rice powder to increase the constipation improvement effect It may further comprise.

Description

Food Composition for Improving Constipation

The present invention relates to a food composition for improving constipation.

Recently, people with constipation have been on the rise due to factors such as busy lifestyle, stress, lack of exercise, and westernization of diet such as increased meat intake.

Constipation is a problem caused by a decline in colorectal peristalsis and is more a symptom than a disease. Medically, constipation is defined as constipation less than three times a week or less than 50g per day (Faigel, 2002). Other symptoms of constipation include irregular bowel movements, painful, hard tilling bowel movements, hard and dry bowel movements, residual stools and abnormal amounts of bowel movements (Bosaeus, 2004).

Constipation may temporarily improve due to an increase in moisture or fiber, but alone is generally insufficient (Muller-Lissmer, 1998). To prevent future constipation, it is necessary to remove the debris from the intestine. Without treatment for constipation, simply increasing the intake of fiber does not solve the problem.

The most common treatments for constipation can be divided into the use of laxatives, the use of probiotic preparations, and the use of natural products such as herbal medicines.

Laxatives consist of bulking agents, stimulants, osmotic and softening (surfactant) laxatives (Bosaeus, 2004) and induce diarrhea.

Probiotic preparations are Lactobacillus acidophilus ), Lactobacillus Lactobacillus of the genus Lactobacillus, such as bifidus ), Bacillus subtilis subtilis ), Bacillus licheniformis ( Bacillus licheniformis ), Bacillus polyfermentus polyfermenticus), Bacillus mesen Terry carcass (Bacillus Bacillus microorganisms such as mesentericus ), and yeasts such as Saccharomyces cerevisiae .

The herbal preparation is used when one or more kinds of extracts or powders are used, such as cha Cha blood, Sukji sulfur, licorice, wolfberry, Schisandra chinensis, aloe and the like.

The present invention discloses a food composition for improving constipation using horse placenta powder and the like.

The present invention is to provide a food composition for improving constipation.

The specific object of the present invention will be presented below.

As confirmed in the following Examples and Experimental Examples, the present inventors have shown that the mixture of the protease-treated powder of horse placenta and Hallabong fruit powder has a marked improvement in constipation as compared to Hallabong fruit powder through clinical evaluation. In the case of the mixture obtained by adding Cha-Phi powder and fermented brown rice powder to the mixture of protease-treated powder and Hallabong fruit powder, the rate of constipation improvement and the regularity, The evaluation of constipation was remarkably improved when assessed by four items: presence or absence of stools, odor of stools, frequency and regularity of bowel movements, degree of stools, presence of odor of stools, and yellow stools. .

The present invention has been completed from these experimental results, the constipation improving food composition of the present invention is characterized in that it comprises a horse protease-treated powder as an active ingredient.

In this specification. "Protein-treated powder of horse placenta" is obtained by treating protease with water as a reaction solvent in horse placenta (especially the chorionic tissue from which the amniotic membrane and umbilical cord were removed). Refers to powder of shape. Protease means an enzyme which hydrolyzes the peptide bond of a protein here, and can use arbitrary what is marketed. Proteases that can be used include, for example, Fabzyme I and II, Flavorzyme, Neutrase and the like.

Food composition for improving constipation of the present invention may be made of horse placental protease-treated powder only, but due to the peculiar odor or specific disgusting taste of horse placental protease-treated powder, there is such a specific odor or disgusting Hallabong fruit powder may be included in an amount of 10 parts by weight or more based on 100 parts by weight of horse placental protease-treated powder to neutralize the taste, and preferably 20 parts by weight, as in the following examples. If the Hallabong fruit powder is included in less than 10 parts by weight may have a low neutralization effect may be a refusal to eat.

In the present specification, " Hallabong tangor ( Citrus kiyomi × ponkan )) ”refers to citrus varieties, also known as cultivars, which have been bred at the Japanese Ministry of Agriculture, Forestry and Fisheries, as a hybrid of dogs ( Citrus kiyomi ) and ponkan ( Citrus reticulata ) (Korean J. Food Preserv., 13 , 538-542, 2006).

On the other hand, as confirmed in the following examples and experimental examples, when the constipation improving composition of the present invention further comprises a chaff blood powder and fermented brown rice powder, the constipation improving effect is significantly increased.

Therefore, the constipation improving food composition of the present invention may further comprise chaff blood powder and fermented brown rice powder, in this case chaff blood powder and fermented brown rice powder in the constipation improving food composition of the present invention horse placenta proteinase treatment powder 100 10 parts by weight or more based on parts by weight, preferably 20 parts by weight, as in the following examples. If the chaff powder and fermented brown rice powder is included in less than 10 parts by weight, the intended improvement in constipation may be insignificant.

As used herein, "chajeonjeop" refers to the species of the plantain or coriander of the related plant (seeds of seeds), chajeonjepi is known that the shell is sweet and tasteful, the nature is cold and effective in diuretic and arthritis. , Hyangjeomsa Dictionary, Younglimsa, pp1005-1006, 1998).

In the present specification, "fermented brown rice" refers to those obtained by inoculating lactic acid bacteria and yeast in the saccharified solution after incubating the brown rice powder obtained by grinding unmilled brown rice with malt containing amylase, maltase and the like.

In the above, "lactic acid bacteria" can be understood as bacteria that produce lactic acid by breaking down sugars such as glucose, and Lactobacillus genus Lactobacillus sp . ), Streptococcus sp . ), Pediococcus sp . ), Leuconostoc sp . ) And Bifidobacterium sp. But are preferably understood to be Lactobacillus vulgaris used in the examples below.

In addition, the term "yeast" refers to Saccharomyces spp., For example Saccharoma

Saccharomyces rouxii), in my process to the three Levy cyano Saccharomyces (Saccharomyces cereviciae), access to the MY Ob pole miss Saccharomyces (Saccharomyces oviformis), a saccharide My process stay Neri (Saccharomyces steineri ), etc. Preferably it means Saccharomyces cerevisiae used in the examples below.

Food composition for improving constipation of the present invention may be prepared in powder form as in the following examples, it may be prepared in the form of pills, liquids, drinks, tablets and the like.

Food composition for improving constipation of the present invention may include sweeteners, flavors, biologically active ingredients, minerals and the like in addition to the active ingredient.

Sweetening agents may be used in an amount that sweetens the food in a suitable manner, and may be natural or synthetic. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.

Flavors may be used to enhance taste or flavor, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. The natural flavor may be obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or may be obtained from green tea leaves, round leaves, jujube leaves, cinnamon, chrysanthemum leaves, jasmine and the like. Also, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. Synthetic flavors may be used depending on the case, and synthetic flavors such as esters, alcohols, aldehydes, terpenes and the like may be used.

Examples of the physiologically active substance include catechins such as catechin, epicatechin, gallocatechin and epigallocatechin, and vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine and riboflavin.

As the mineral, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium and zinc can be used.

In addition, the food composition of the present invention may contain preservatives, emulsifiers, acidifiers, thickeners and the like as needed in addition to the above sweeteners.

Such preservatives, emulsifiers and the like are preferably added in a very small amount as long as they can attain an application to which they are added. The term " trace amount " means, when expressed numerically, in the range of 0.0005% by weight to about 0.5% by weight based on the total weight of the food composition.

Examples of the preservative which can be used include calcium sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate and EDTA (ethylenediaminetetraacetic acid).

Examples of the emulsifier which can be used include acacia gum, carboxymethyl cellulose, xanthan gum, pectin and the like.

Examples of the acidulant that can be used include acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid. Such an acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.

Agents that may be used include suspending agents, sedimentation agents, gel formers, bulking agents and the like.

In addition, herbal medicines may be added to enhance flavor and taste and to add other functionalities. Herbal medicines that may be added include tofu extract, sokdan extract, antler extract, safflower extract, tosa extract, succinate extract, tortoise extract, and cornus extract , Goji berry extract, licorice extract, Angelica extract, brown root extract, kangjinhyang extract, Haphwanpi extract, wild boiled root extract, lump extract, red ginseng extract, wild ginseng culture root extract, goat mountain ginseng extract and the like can be exemplified.

As described above, according to the present invention can provide a food composition for improving constipation.

Food composition for improving constipation of the present invention comprises a horse placenta proteinase-treated powder as an active ingredient, may further comprise Hallabong fruit powder to neutralize the specific odor of horse placenta proteinase-treated powder, constipation In order to increase the improvement effect, the chaff and fermented brown rice powder may be further included.

The food composition for improving constipation of the present invention by containing the Hallabong fruit powder additionally hardly felt the peculiar smell of the placental protease-treated powder when ingested, the following experiment by further comprising the cha-Phi powder and fermented brown rice powder As shown in the example, it shows a high effect of constipation.

Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these examples and experimental examples.

< Example > Preparation of the composition for improving constipation

<Example 1> Preparation Example 1 of the composition for improving constipation

100 parts by weight of horse placenta proteinase-treated powder and 20 parts by weight of Hallabong fruit powder based on 100 parts by weight of horse placenta proteinase-treated powder were prepared to improve constipation. Here, Hallabong fruit powder is added to neutralize horse placental protease-treated powder has a placental odor and placenta specific disgusting taste.

The horse placental protease-treated powder was obtained by the following method. In other words, the chorionic tissue of the horse placenta from which the amniotic membrane and the umbilical cord were removed was washed several times with water, and blood was removed and then lyophilized and powdered. Then, 1 kg of horse's placenta powder, 3 L of water and 10 g of protease (NOVO) were added to After reacting at 40 ° C. for 2 hours at, the enzyme was stopped by increasing the temperature, and the reaction solution was concentrated under reduced pressure to evaporate water to prepare a placental proteinase powder.

In addition, the Hallabong fruit powder was obtained by slicing the Hallabong fruit (including skin and pulp) and lyophilizing the sliced material.

<Example 2> Preparation Example 2 of the composition for improving constipation

100 parts by weight of horse placenta proteinase-treated powder, 20 parts by weight of Hallabong fruit powder based on 100 parts by weight of horse placenta proteinase-treated powder, 20 parts by weight of chaff skin powder based on 100 parts by weight of horse placenta proteinase-treated powder, fermented brown rice powder Mixing 20 parts by weight to prepare a composition for improving constipation.

The chaff powder was purchased from the market used, fermented brown rice powder is obtained by freeze-dried and powdered fermented brown rice,

Fermented brown rice is put in water at the same weight as brown rice in unrefined brown rice powder (including rice bran), to which a roughly ground malt (malt) corresponding to 1% of the brown rice weight is added, and the temperature is 60 ° C to 62 ° C. After saccharification for about 6 hours in the range, the saccharified solution was sterilized for 30 minutes at 120 ° C. and 1.4 atm, and lactic acid bacteria (Lactobacillus bulgaricus; 1.0 X 10 ⁸ Cell / mL) was added to about 1.5 L of the sterilized saccharified solution. The rice bran fermentation composition was prepared by adding 100 ml of a culture solution containing yeast (Saccharomyces cerevisiae; 1.0 X 10 ⁷ Cell / ml) in a 1: 1 ratio and fermenting at about 40 ° C. for 2 days.

< Experimental Example > Constipation Improvement Effect Experiment

Constipation-improving activity of the composition for improving constipation prepared in the above Example was evaluated in a clinical trial targeting 60 men and women with constipation symptoms. Considering that constipation is stiff, yellowish yellow, the number of bowel movements and the amount of stool decreases, is irregular, and the odor of the stool is severe and unpleasant with stools, the person with constipation is less than four times a week. The degree of improvement in constipation symptoms was evaluated by the number of bowel movements, regularity, degree of residual feeling, odor of stools, and yellow stools.

Sixty people were divided into three groups, the first group was given the composition of <Example 1>, the second group was given the composition of <Example 2>, and the third group was given only Hallabong fruit lyophilized powder. Dosage was taken 1 to 2 teaspoons 2-3 times a day. here

After taking 6 weeks in total, the symptoms of constipation were assessed in the form of a questionnaire at the 6th week. Evaluation was made according to the following evaluation criteria.

The evaluation criteria are as follows.

[Number of bowel movements and regularity]

5 points | pieces: A side is seen once a day regularly.

3 points | pieces: It is not regular but generally sees a side once a day.

1 point | piece: There is no improvement compared with before the test.

[With or without residue]

5 points | pieces: There is no residual feeling.

3 points | pieces: There is generally no residual feeling.

1 point | piece: There is no improvement compared with before an experiment.

[Smell of stools]

5 points | pieces: The odor of the stool improved significantly.

3 points | pieces: The odor of stools improves.

1 point | piece: There is no improvement compared with before an experiment.

[Whether or not you see the yellow side]

5 points | pieces: A yellow edge is seen.

3 points | pieces: Mostly see a yellow edge.

1 point | piece: There is no improvement compared with before an experiment.

Frequency and regularity of bowel movements division 5 points 3 points 1 point Example 1 12 3 5 Example 2 18 2 0 Comparative Example 2 2 16

Whether there is residual feeling (person) division 5 points 3 points 1 point Example 1 8 4 8 Example 2 17 3 0 Comparative Example 4 2 14

Smell of stool (person) division 5 points 3 points 1 point Example 1 10 4 6 Example 2 19 One 0 Comparative Example One 4 15

Yellow stools division 5 points 3 points 1 point Example 1 11 4 5 Example 2 14 4 2 Comparative Example 0 2 18

The results of Table 1 indicate that in the frequency and regularity of bowel movements, the Hallabong lyophilized powder of the comparative example showed improvement in 4 out of 20 people, but in the case of taking the composition of the example, the improvement effect was obtained. In many cases, especially when the composition of <Example 2> was taken, most of the participants showed a response to 'seeing once a day regularly'.

The results of [Table 1] are generally similar to the results of [Table 2] for the presence or absence of residual feeling, [Table 3] for the odor level of the stools, and [Table 4] for the yellow stools. Showed a tendency.

Claims (5)

A food composition for improving constipation comprising a protease-treated powder, Hallabong fruit powder, chajeonpi powder and fermented brown rice powder of horse placenta as an active ingredient.
delete The method of claim 1,
The composition is constipation improving food composition comprising Hallabong fruit powder 10 parts by weight or more 20 parts by weight or less based on 100 parts by weight of the protease treatment powder of horse placenta.
delete The method of claim 1,
The composition is a constipation improving food composition comprising 10 parts by weight or more and 20 parts by weight or less based on 100 parts by weight of the chaff blood powder and fermented brown rice powder.