KR101298824B1 - Metabolic Cage - Google Patents

Metabolic Cage Download PDF

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Publication number
KR101298824B1
KR101298824B1 KR1020110042289A KR20110042289A KR101298824B1 KR 101298824 B1 KR101298824 B1 KR 101298824B1 KR 1020110042289 A KR1020110042289 A KR 1020110042289A KR 20110042289 A KR20110042289 A KR 20110042289A KR 101298824 B1 KR101298824 B1 KR 101298824B1
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KR
South Korea
Prior art keywords
urine
collection
laboratory animal
collection unit
collecting
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Application number
KR1020110042289A
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Korean (ko)
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KR20120124573A (en
Inventor
최영희
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동국대학교 산학협력단
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Priority to KR1020110042289A priority Critical patent/KR101298824B1/en
Publication of KR20120124573A publication Critical patent/KR20120124573A/en
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Publication of KR101298824B1 publication Critical patent/KR101298824B1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K23/00—Manure or urine pouches
    • A01K23/005—Manure or urine collecting devices used independently from the animal, i.e. not worn by the animal but operated by a person

Abstract

The present invention is a cylindrical body having a hollow extending in the longitudinal direction; A mesh body formed on one side of the body to separate the body into a living space in which a laboratory animal lives and a collection space for collecting feces of the laboratory animal; A collection unit provided in the collection space of the body separated by the mesh body to collect the urine of the experimental animal; A urine collection unit disposed adjacent to the lower end of the collection unit and storing urine collected therein; And it provides a place where the urine collecting portion and at the same time connected to the inner side of the body connected to the metabolic cage comprising a urine collecting means for fixing the urine collecting.

Description

Metabolic Cage

The present invention relates to a metabolic cage, and more particularly, to a metabolic cage that enables automatic blood collection and urine collection at the same time while the laboratory animal is freely movable.

Laboratory animals most commonly used in medical / biological research include hamsters, mice, and rats.

Blood collection and drug administration using these experimental animals are frequently performed experiments to confirm the efficacy, safety and risk in the development of medicines, cosmetics, pesticides, and the like.

In particular, preclinical studies on the pharmacokinetic aspects of drug absorption, distribution, metabolism, and excretion are required at the drug evaluation stage, and research on this is being actively conducted as the discovery of new drug candidates increases.

In addition, the measurement of plasma and urine drug concentrations, which are the basis of pharmacokinetic studies, requires the collection of blood from laboratory animals for a certain period of time. For this, an appropriate metabolic cage is provided that provides a space for the laboratory animals to live. Should be provided.

On the other hand, the conventional pharmacokinetic preclinical study mainly used rats as experimental animals due to the difficulty of surgery for blood collection, which requires a large amount of new drug candidates, difficult to secure various disease models, The importance of pharmacokinetic studies using mice is increasing.

In particular, the automatic blood collection device (system) of the experimental animal allows the metabolic cage to rotate together with the free movement of the mouse, and the tube inserted into the blood vessel of the mouse for blood collection can be stably maintained.

The present invention provides a metabolic cage that allows automatic blood collection and urine collection at the same time while the laboratory animal is freely movable.

The present invention

A cylindrical body having a hollow extending in the longitudinal direction;

A mesh body formed on one side of the body to separate the body into a living space in which a laboratory animal lives and a collection space for collecting feces of the laboratory animal;

A collection unit provided in the collection space of the body separated by the mesh body to collect the urine of the experimental animal;

A urine collection unit disposed adjacent to the lower end of the collection unit and storing urine collected therein; And

It provides a place where the urine collecting portion is provided at the same time connected to the inner side of the body provides a metabolic cage comprising a urine collecting means for fixing the urine collecting portion.

The metabolic cage according to the present invention allows automatic blood collection and urine collection at the same time while the laboratory animal is freely movable.

1 is a block diagram showing a metabolic cage according to the present invention,
Figure 2 is a schematic diagram showing an automatic blood collection device is connected to the metabolic cage according to the present invention.

The present invention is a cylindrical body having a hollow extending in the longitudinal direction; A mesh body formed on one side of the body to separate the body into a living space in which a laboratory animal lives and a collection space for collecting feces of the laboratory animal; A collection unit provided in the collection space of the body separated by the mesh body to collect the urine of the experimental animal; A urine collection unit disposed adjacent to the lower end of the collection unit and storing urine collected therein; And it provides a place where the urine collecting portion is provided at the same time connected to the inner side of the body provides a metabolic cage comprising a urine collecting means for fixing the urine collecting.

The metabolic cage according to the present invention allows the experimental animal to move freely and collect blood and urine collection even when the tube is inserted into the blood vessel of the experimental animal for blood collection, and is not particularly limited as long as it is a metabolic cage having this purpose.

At this time, the metabolic cage is rotated in accordance with the movement of the laboratory animal and the tube connected to the blood vessels of the laboratory animal is kept stable.

Specifically, the metabolic cage according to the present invention is applied to a conventional automatic blood collector device (system) of the art which allows for automatic blood collection through a tube connected to a blood vessel of a laboratory animal.

On the other hand, laboratory animals according to the present invention include hamsters, mice, rats or their modality.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings. However, the following description is only for the purpose of specifically describing the present invention, and the scope of the present invention is not limited by the following description.

1 is a block diagram showing a metabolic cage according to the present invention, Figure 2 will be described together as a schematic diagram showing an automatic blood collection device that is connected to the metabolic cage according to the present invention.

As shown in Figs. 1 and 2, the metabolic cage 2 according to the present invention comprises a cylindrical body 4 having a hollow extending in the longitudinal direction; A mesh body (10) formed at one inner side of the body (4) to separate the body (4) into a living space (6) where a laboratory animal lives and a collection space (8) for collecting feces of the laboratory animal; A collection part 12 provided in the collection space 8 of the body 4 separated by the mesh body 10 to collect the urine of the experimental animal; A urine collecting part 14 provided adjacent to the lower end of the collecting part 12 to collect the urine collected into the collecting part 12; And a urine collecting means 16 for providing a place where the urine collecting portion 14 is seated and connected to an inner side of the body 4 to fix the urine collecting portion 14.

The body 4 according to the invention consists of a cylinder having a hollow extending in the longitudinal direction.

The body 4 is preferably made of a transparent material to observe the inside.

At this time, the interior of the body (4) can be divided into a living space (6) for the laboratory animal living and a collection space (8) for collecting the feces of the laboratory animal, the living space (6) and the collection space (8) ) Is separated by the mesh body 10 formed on the inner side of the body (4).

The mesh 10 may not have a stool in the feces of the laboratory animal living in the living space 6, it is preferable that the mesh has a size that can pass only urine.

Specifically, the body 4 according to the present invention may be provided with at least one opening or closing portion 18 on one side of the outer circumferential surface thereof so that the user can easily access the inside of the body 4.

At this time, the opening and closing part 18 may be a door that can be opened and closed in a manner of opening and closing, the opening and closing portion (up / down) of the body 4 to be accessible to the living space 6 and the collection space (8) formed in the body (4) 18 ', 18 ") are preferably formed respectively.

The collection unit 12 according to the present invention is provided in the collection space 8 of the body 4 separated by the mesh body 10 for collecting, for example, collecting urine from laboratory animals. As a conventional collection part 12 having such a purpose, it is not particularly limited.

The collection part 12 is a funnel form or conical connected to the center of the body 4 in a downward direction from the boundary surface of the mesh body 10 and the body 4 so as to cover the entire lower end of the mesh body 10 ( It is good to have a conical form.

Specifically, the collection unit 12 according to the present invention is further provided with a mesh net 22 to prevent the feces of the laboratory animal passing through the mesh 10 in the inlet into the urine collecting portion 14 therein. Can be.

The urine collecting unit 14 according to the present invention is provided adjacent to the lower end of the collecting unit 12 to provide a place in which the urine collected in the collecting unit 12 is introduced and stored.

The urine collecting part 14 may be a container opened upward.

The urine collecting means 16 according to the present invention is provided with a place where the urine collecting portion 14 is seated, and is connected to one side of the inner side of the body 4, for example, one side of the inner circumferential surface of the body 4. 14), any of the urine collecting means 16 for this purpose may be used.

Here, the urine collecting means 16 is connected to one side of the inner surface of the body 4, the urine collecting portion 14 is moved during the rotation of the metabolic cage 2 of the experimental animal stored in the urine collecting portion 14 Urine can be prevented from leaking to the outside.

On the other hand, the metabolic cage 2 according to the present invention having the above-described configuration is applied to an automatic blood collecting device to enable free blood collection and collection of laboratory animals in which tubes are fixed to blood vessels for blood collection.

Here, the automatic blood collection device (system) is a conventional device in the art used for pharmacokinetic studies on the absorption, distribution, metabolism and excretion of drugs.

Specifically, the automatic blood collection device is provided with a rotating plate 24 on which the metabolic cage 2 is seated so as to rotate the metabolic cage 2.

At this time, the rotating plate 24 is configured in a disk shape having a hollow, the lower end of the hollow is provided with a sensor for observing the metabolic cage (2).

Thus, the body 4 of the metabolic cage 2 according to the present invention is preferably formed in a diameter smaller than the inner diameter of the rotating plate (24).

In addition, the outer peripheral surface of the body 4 of the metabolic cage 2 is seated on the upper surface of the rotary plate 24 so that the metabolic cage 2 can be easily and safely rotated along the outer circumferential surface along the outer peripheral surface of the body 4 so as to have a predetermined length. A plate-shaped fixing plate 20 protruding vertically may be provided.

As described above, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. It is therefore to be understood that the embodiments described above are all illustrative and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention without departing from the scope of the present invention.

2: metabolism cage 4: body
6: living space 8: collecting space
10: mesh 12: collecting unit
14: collection unit 16: collection unit fixing means
18: opening and closing part 20: fixed plate
22: mesh network 24: rotating plate

Claims (11)

delete delete delete delete delete delete Cylindrical body having a hollow extending in the longitudinal direction, formed on one inner side of the body to separate the body into a living space in which the laboratory animal living and the collection space for collecting the excretion of the laboratory animal, by the mesh A collection unit provided in the collection space of the separate body for collecting the urine of the laboratory animal, the collection unit is provided adjacent to the lower end of the collection unit collected urine collected into the collection unit, the place where the urine is seated At the same time, it is connected to the inner side of the body to fix the urine collection portion, the container-shaped urine collecting means for preventing the leakage of the laboratory animal stored in the urine collection unit and the outer peripheral surface along the outer peripheral surface of the body Metabolism cage comprising a plate-like fixed plate protruding a predetermined length vertically to
And a rotating plate on which the metabolic cage is seated to rotate the metabolic cage, wherein the rotating plate has a hollow disc shape. The method of claim 7, wherein
An automatic blood collection device comprising the collector having a funnel or conical shape. 9. The method of claim 8,
Automatic blood collection device comprising a mesh network further provided inside the collection. The method of claim 7, wherein
Automatic blood collection device comprising one or more opening and closing portion is provided on one side of the outer peripheral surface of the cylindrical body. The method of claim 7, wherein
The laboratory animal is a hamster, a mouse, a rat or both automatic blood collection device.
KR1020110042289A 2011-05-04 2011-05-04 Metabolic Cage KR101298824B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020110042289A KR101298824B1 (en) 2011-05-04 2011-05-04 Metabolic Cage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110042289A KR101298824B1 (en) 2011-05-04 2011-05-04 Metabolic Cage

Publications (2)

Publication Number Publication Date
KR20120124573A KR20120124573A (en) 2012-11-14
KR101298824B1 true KR101298824B1 (en) 2013-08-23

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112586372A (en) * 2020-12-25 2021-04-02 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 Mouse metabolism cage

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080196672A1 (en) * 2005-06-30 2008-08-21 Armand Mokhtarian Metabolic Cage For Small Rodents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080196672A1 (en) * 2005-06-30 2008-08-21 Armand Mokhtarian Metabolic Cage For Small Rodents

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