KR101265981B1 - System and method for producing a vertebra information of korean human body - Google Patents

Abstract

PURPOSE: A Korean human body backbone information manufacturing method and a system thereof are provided to measure a 3D backbone model in a computer, thereby accurately measuring a Korean human body backbone. CONSTITUTION: A transformed parameter is inputted in a CT(Computerized Tomography) image(S202). A human body backbone data set is generated by input(S204). In the CT image, masking data is generated(S206). A base mask is generated according to each backbone(S210). The base mask is processed by smoothing(S212). [Reference numerals] (AA) Start; (BB) End; (S202) Obtain a CT image by photographing human body backbone with a CT scan through an image acquisition unit; (S204) Generate a human body backbone data set by receiving a conversion parameter for the CT image; (S206) Generate masking data by classifying a part corresponding to each backbone with a separate color in the CT image of the human body backbone data set; (S208) Set an HU threshold through the confirmation of an HU value for a desired area; (S210) Generate a base mask by zoning the image per each backbone; (S212) Generate 3D model data by smoothing the base mask to indicate shape characteristics of each backbone; (S214) Obtain numerical information of main part indicating the shape of the backbone by measuring at the outside of the backbone or a cut section for the 3D model data or measuring the height of disk; (S216) Calculate bone mineral density of pure body parts except for a backbone column part by cutting pedicles adjacent to a vertebral body for the 3D model data; (S218) Extract the backbone from a first neck bone(C1) to a sacrum and perform a bone mineral density(BMD) test; (S220) Perform a spinal segmental functional test with two backbones as one set; (S222) Store a bone mineral density test result and a functional test result by corresponding to the 3D model data; (S224) Measuring compressive strength by mounting with resin to apply uniform load on the upper and lower plates of the cut backbone body; (S226) Store the measured compressive strength by corresponding to the 3D model data

Description

System and method for producing a vertebra information of Korean human body}

The present invention is a computerized tomography (CT) of the human spine of the Korean by the three-dimensional shape information about the appearance of the vertebrae and the numerical information obtained by measuring a specific point of the spine shape, and the segmental function of the vertebral body and The present invention relates to a method and system for producing Korean human spine information that enables the production of physical property information indicative of compressive strength.

Information about the human body is needed in a wide range of fields, from medicine, science and engineering to the planning and design of the food, food and state environment. In addition to the medical field that treats sore places, it is used in various fields such as producing products suitable for human beings and designing optimized living environments.

The human body model is a model that replaces human beings in computer virtual space and is a model used to predict the consequences of dangerous situations in which a person cannot directly enter a laboratory. In other words, it is a model used to predict outcomes on behalf of humans in the environment given by purpose. The human body model is composed of shape information that provides information on the appearance of the human body, physical property information on the properties of various parts of the human body, and motion information on the movement of each part of the human body.

However, the information on the human body of Koreans is to be measured by the Korean Agency for Technology and Standards. Korea's only human body size measurement project (Size Korea) that measures the shape of the human body. The project includes about 20,000 Koreans, direct measurements using an anthropometer, motion measurements using special measurement equipment, and three-dimensional shapes and automatically measured human dimensions in 3D measurements using a full-body scanner.

However, this Korean human body size research project uses a Korean external 3D scanner, so it only has external 3D shape information, and does not include the shape information or the physical properties of the skeleton or skeleton inside the Korean body. As described above, the shape and physical properties of the Korean skeleton can be said to be essential information that can be usefully used for the development of a three-dimensional human model or the development of artificial joints and implants.

On the other hand, human body modeling and human visualization research is being embodied by the convergence of IT and medical fields. Initially using CT or MRI images of the human body as part of a simple treatment process, various tomography devices and technologies have been developed to create three-dimensional stereoscopic images from simple two-dimensional images. It is utilized in.

Therefore, due to the development of human body modeling technology, various three-dimensional human body models are used more and more, and they are used as image analysis and diagnosis of diseases and new surgical treatment aids, and human body structure such as rehabilitation, sports, automobile, military, safety and image production. There is a need for a technique for producing Korean human spine information that can be widely applied in a field directly or indirectly related to it.

Republic of Korea Patent No. 1,137,991 (Registration date: April 12, 2012)

An object of the present invention for meeting the above-described needs is, by performing a computed tomography (CT) of the human spine of the Korean people, the three-dimensional shape information on the appearance of the vertebrae and numerical information obtained by measuring a specific point of the spine shape, In addition, the present invention provides a method and system for producing Korean human spine information that enables the production of physical information representing the segmental functionality and compressive strength of the vertebral body.

According to an aspect of the present invention for achieving the above object, in the method of producing human spine information using the CT image obtained by computed tomography of the human spine, (a) the CT image Generating a human spine data set by receiving a conversion parameter with respect to the control unit; (b) generating masking data by distinguishing a region corresponding to each vertebra from the CT image of the human vertebrae data set with a separate color; (c) setting a HU area threshold by checking HU values for areas desired by a user in each vertebra; (d) generating a base mask by image segmenting the respective vertebrae; And (e) smoothing the basic mask to generate three-dimensional model data so as to represent the shape characteristics of the respective vertebrae.

In addition, in the step (a), the conversion parameter may include the number of horizontal and vertical pixels, the Pixel Size, and the Slice Distance.

In addition, in the step (a), the human spine data set may be said to have completed six orientations of anterior, posterior, right, left, top, and bottom for the image.

Also, in the step (d), the image segmentation for each vertebra is performed by copying a mask for each vertebra and for clarifying an image region of the vertebra for each vertebra. By removing and modifying the boundary region of the bone to have a separate mask for each vertebrae can be said to distinguish each of the vertebrae.

In addition, the method may further comprise the step of obtaining the numerical information of the main part representing the shape of the spine with respect to the three-dimensional model data in the vertebrae outline, measured in the cutting plane or by measuring the height of the disk. .

In addition, the measurement of the height of the disk can be measured in the middle plane by cutting the height of the disk in the sagittal plane, and by cutting the coronal plane around the center of the body center can measure the height of the disk in the plane.

In addition, the measurement in the sagittal plane may correspond to all areas of the neck, spine and lumbar spine, and the measurement in the coronal plane may correspond to the spine and lumbar spine.

In addition, the measurement of the neck disk height may be measured based on the corner points of the front, middle, and end of the vertebral body in the sagittal plane.

In addition, (g) may further include calculating the bone density of the pure body portion excluding the spinal posterior region by cutting in the pedicle adjacent to the vertebral body with respect to the three-dimensional model data based on the HU value according to the following equation.

In addition, the Hu value of the body portion of the vertebrae can be calculated by cutting the pedicle of the vertebral arch (pedicle of vertebral arch) close to the body.

In addition, (h) performing a bone mineral density (BMD) test by applying Dual Energy X-ray Absorption (DEXA) to the vertebral joints in which each spine is cut; And (i) storing the bone density test results in correspondence with the 3D model data.

Further, (j) further comprising the step of performing a spinal segment functional test in a pair of two vertebrae, wherein the spinal segment functional test is to test the bending-response characteristics in each motor segment, A tester that can produce pure bending moment load by making two connected vertebrae into a set of test specimens and fixing the upper vertebral upper end plate and the lower vertebral lower end plate with resin containing bone cement. The angle of rotation is recorded in each load step by applying forward bending, 폄, left bending, right bending, torsion (clockwise, counterclockwise), and compression load.

In addition, (k) for the test body in which each vertebral joint consisting of the neck, spine, and lumbar spine was removed, the soft tissues including muscles and ligaments were removed, and the pedicle portion was cut close to the trunk, the stomach of the cut spinal torso Measuring compressive strength by mounting with resin so that a uniform load is applied to the lower plate; And (l) storing the measured compressive strength in correspondence with the 3D model data.

And, the step (k) is to measure the compressive strength by applying a load at a constant speed to the test body using a universal testing machine, 20 to 20 of the height of the spinal torso height (average of the front, rear torso height) from the time the compressive force is applied The compressive strength can be measured by applying a compression equal to 30% displacement.

On the other hand, according to another aspect of the present invention for achieving the above object, a CT image acquisition unit for obtaining a CT image by computed tomography of the human spine; Generate a human spine data set by receiving a conversion parameter for the CT image, and generate masking data by distinguishing a region corresponding to each vertebra in a CT image of the human spine data set by a separate color. A masking data generator; A base mask generation unit for generating a base mask by setting a HU region threshold by checking a HU value for a region desired by the user in each vertebra and segmenting the image for each vertebra. ; A model data generation unit for generating three-dimensional model data by smoothing the basic mask to represent the shape characteristics of each vertebra; Numerical information acquisition unit for obtaining the numerical information of the main portion representing the shape of the spine with respect to the three-dimensional model data in the vertebrae outline, measured in the cutting plane or by measuring the height of the disk; A bone density calculator for cutting the 3D model data from a pedicle adjacent to the vertebral body and calculating a bone density (ρ) of the pure body portion excluding the spinal posterior region based on the HU value; BMD test is performed for each vertebral joint by applying Dual Energy X-ray Absorption (DEXA), and the bone density measuring unit stores the bone density test result in correspondence with the 3D model data. ; Spinal segment functional test unit for performing a spinal segment functional test in a pair of the two extracted vertebrae; And a test piece in which each vertebral joint consisting of the neck, spine, and lumbar spine is removed, the soft tissue including the muscles and ligaments is removed, and the pedicle portion is cut close to the trunk, the upper and lower plates of the cut spinal trunk. There is provided a system for producing human spine information including a compressive strength measuring unit mounted on a resin to measure a uniform load and measuring compressive strength, and storing the measured compressive strength in correspondence with the three-dimensional model data.

Here, the conversion parameter may include the number of pixels horizontally and vertically, the pixel size, and the slice distance.

In addition, the human spine data set is the six direction setting of the image, Anterior, Posterior, Right, Left, Top and Bottom is completed.

In addition, the image segmentation for each vertebra is to copy the basic mask to each vertebra, and to remove the boundary region of the neighboring vertebrae to clarify the image area of the vertebra for each mask. And modified to have an independent mask for each vertebrae to distinguish each of the vertebrae.

In addition, the measurement of the disk height of the numerical information acquisition unit is to measure the height of the disk in the sagittal plane by cutting in the median cross-section, and to measure the height of the disk in the plane by cutting the coronal plane to the center of the body center.

In addition, the measurement in the sagittal plane may correspond to all areas of the neck, spine and lumbar spine, and the measurement in the coronal plane may correspond to the spine and lumbar spine.

In addition, the measurement of the neck disk height may be measured based on the corner points of the front, middle, and end of the vertebral body in the sagittal plane.

In addition, the bone density calculation unit, by cutting in the pedicle adjacent to the vertebral body with respect to the three-dimensional model data may calculate the bone density of the pure body portion excluding the spinal posterior region based on the HU value according to the following equation.

In addition, the Hu value of the body portion of the vertebrae can be calculated by cutting the pedicle of the vertebral arch (pedicle of vertebral arch) close to the body.

In addition, the bone density measurement unit, by applying a Dual Energy X-ray Absorption (DEXA, Dual Energy X-ray Absorption) for each spine joint to perform a bone density (BMD) test, the bone density test results to the 3D model data Will be stored in response to

In addition, the spinal segment functional test unit is made of a test body of two pairs of vertebrae connected to the intervertebral disc, and a resin including bone cement in the upper vertebral upper end plate and the lower vertebral lower end plate part. Mounted on the tester capable of pure moment load by fixing it in the direction of rotation, and applying the forward bending, 폄, left bending, right bending, torsion (clockwise, counterclockwise), and compression load Will be recorded.

In addition, the compressive strength measuring unit, by applying a load to the test body at a constant speed using a universal material tester to measure the compressive strength, from the time the extruded force is applied 20 of the spine trunk height (an average of the front and rear trunk height) The compressive strength can be measured by applying compression by a displacement corresponding to 30%.

According to the present invention, CT or MRI imaging of the human human spine can be made by zoning individual bones of the human spine to produce a three-dimensional skeletal model, and by measuring the three-dimensional spine model in various ways on a computer, the numerical information of the Korean spine. Can be produced. In addition, the spine of Koreans can be extracted in a specific way to measure spine physical properties such as deflection, bending, torsion, and compressive strength.

The Korean spine's shape and physical information can be used as input data for developing various human spine models or various artificial spinal discs. It can be used as a new surgical treatment aid such as evaluation of the shape, shape design of artificial spinal disc, education and training of spinal surgery, and development of various spinal surgery simulators. It can be applied in a wide range of fields.

1 is a block diagram schematically showing a functional block of the human spine information production system according to an embodiment of the present invention.
2 is a flowchart illustrating an operation for explaining a method for producing human spine information according to an exemplary embodiment of the present invention.
3 is a diagram illustrating an example of receiving a conversion parameter according to an embodiment of the present invention.
4 is a diagram illustrating an example of a human spine data set generated according to an embodiment of the present invention.
5 is a diagram illustrating an example of setting a threshold value by checking a profile line of a selected region according to an exemplary embodiment of the present invention.
6 is a diagram illustrating an example of a screen for generating a basic mark according to an embodiment of the present invention.
7 is a view showing an example of the 3D object of the vertebrae created in accordance with an embodiment of the present invention.
FIG. 8 is a diagram illustrating an example of measuring dimensions 3-7 of the cervical vertebrae from three-dimensional model data according to an exemplary embodiment of the present invention.
9 is a view showing an example of measuring the spine 1-12 dimension in the three-dimensional model data according to an embodiment of the present invention.
10 is a view showing an example of measuring the dimension 1-5 of the lumbar spine in the three-dimensional model data according to an embodiment of the present invention.
11 is a view showing an example of measuring the height of the disk in the sagittal plane according to an embodiment of the present invention.
12 is a view showing an example of measuring the height of the disk in the coronal plane according to an embodiment of the present invention.
13 is a view showing an example of measuring the height of the neck bone disc according to an embodiment of the present invention.
14 is a view showing an example of performing a bone density test on the spinal joint according to an embodiment of the present invention.
15 is a view showing an example of a functional test, such as bending test or spinal disc compression test for spinal segments according to an embodiment of the present invention.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. However, this is not intended to be limited to the particular embodiment of the present invention, it should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention.

An embodiment of a method and system for producing human spine information in accordance with the present invention will be described in detail with reference to the accompanying drawings. In the description with reference to the accompanying drawings, the same or corresponding components will be given the same reference numerals and redundant description thereof will be omitted.

1 is a block diagram schematically showing a functional block of a system for producing human spine information in accordance with an embodiment of the present invention.

Referring to FIG. 1, the Korean human spine information production system 100 according to an embodiment of the present invention may include an image acquirer 110, a masking data generator 120, a basic mask generator 130, and model data generation. The unit 140, the numerical information acquisition unit 150, bone density calculation unit 160, bone density measurement unit 170, spinal segment functional test unit 180 and compressive strength measurement unit 190 and the like.

The image acquirer 110 acquires a CT image by performing a computed tomography (CT) scan of the human spine. Here, the image acquisition unit 110 may acquire an image of the human spine by MRI in addition to CT imaging.

The masking data generation unit 120 receives a conversion parameter for the CT image to generate a human spine data set, and a region corresponding to each vertebra in the CT image of the human spine data set as a separate color. Create masking data separately. Here, the conversion parameter may include the number of pixels horizontally and vertically, the pixel size, and the slice distance. In addition, the human spine dataset has six orientation settings for the image: Anterior, Posterior, Right, Left, Top, and Bottom.

The base mask generation unit 130 sets the HU area threshold by checking the HU value for the area desired by the user in each vertebra, and sets a base mask by image segmentation for each vertebra. Create In addition, image segmentation for each vertebra also copies the mask from each vertebra to the base mask, and removes and modifies the border regions of neighboring vertebrae to clarify the image area for that vertebra per mask. Each vertebra has a separate mask to separate each vertebra.

The model data generator 140 smoothes the basic mask to represent the shape characteristics of each vertebra and generates three-dimensional model data.

The numerical information acquiring unit 150 acquires numerical information of a main part representing the shape of the spine with respect to the 3D model data by measuring the shape of the vertebrae, measuring the cutting surface, or measuring the height of the disc.

In addition, the numerical information acquisition unit 150 measures the height of the disk in the sagittal plane by cutting in the middle section for the measurement of the height of the disk, and by cutting the coronal plane to the center of the body center to measure the height of the disk in the plane.

At this time, the measurement in the sagittal plane corresponds to all areas of the neck, spine and lumbar spine, and the measurement in the coronal plane may correspond to the spine and lumbar spine. In addition, the neck height can be measured based on the corner points of the front, middle and end of the vertebral body in the sagittal plane.

In addition, the bone density calculation unit 160 may calculate the bone density (ρ) of the pure body portion excluding the vertebral posterior region by cutting at the pedicle adjacent to the vertebral body with respect to the 3D model data based on the HU value according to Equation 1 below. Can be.

In addition, the Hu value of the body portion of the vertebrae can be calculated by cutting the pedicle of the vertebral arch (pedicle of vertebral arch) close to the body.

When the vertebral joints composed of the neck, spine, and lumbar spine are extracted, the bone density measuring unit 170 applies dual energy X-ray absorption (DEXA) to each of the extracted vertebral joints. BMD) test is performed, and the bone density test result is stored in correspondence with the 3D model data.

That is, the bone density measuring unit 170, the first spine from the first neck (C1) to the sacral (sacrum) to extract the vertebrae at the same time to test the motion characteristics of each vertebral joint consisting of seven neck bones, 12 spines, 5 hips, The upper part cuts the external occipital protuberance, the side cuts the ribs 1 cm or more away from the transverse process, and the lower end of the sacrum. (S1) The lower part is cut and extracted, and bone density (BMD) test is performed on each extracted vertebral joint by applying Dual Energy X-ray Absorption (DEXA). It is stored in correspondence with the three-dimensional model data.

In addition, the spinal segment functional test unit 180, the two vertebrae connected to the intervertebral disc is produced in a set of test bodies, and the upper vertebral upper end plate and the lower vertebral lower end plate part includes bone cement. It is fixed to resin and mounted on a tester capable of pure moment load, and is applied at each load step by applying forward bending, 폄, left bending, right bending, torsion (clockwise, counterclockwise), and compression load. The rotation angle will also be recorded.

The compressive strength measuring unit 190 extracts each vertebral joint composed of the neck, spine, and lumbar spine, removes the soft tissue including the muscle and the ligaments, and cuts the pedicle to the torso. The compressive strength is measured by mounting the resin so that a uniform load is applied to the upper and lower plates of the upper and lower plates, and the measured compressive strength is stored in correspondence with the 3D model data.

In addition, the compressive strength measuring unit 190, by applying a load to the test body at a constant speed using a universal testing machine to measure the compressive strength, the height of the spine torso (the average of the front and rear torso height) from the time the extrusion force is applied The compressive strength can be measured by applying compression by a displacement corresponding to 20-30% of.

FIG. 2 is a flowchart illustrating an operation method for explaining a method of manufacturing Korean human spine information according to an exemplary embodiment of the present invention.

Referring to FIG. 2, the Korean human spine information production system 100 according to an embodiment of the present invention first obtains a CT image by CT imaging a human spine through the image acquisition unit 110 (S202).

In this case, the image acquisition unit 110 may be implemented not only as a CT imaging apparatus for acquiring a CT image, but also as a magnetic resonance (MRI) imaging apparatus for capturing the human spine using magnetic resonance.

Subsequently, the Korean human spine information production system 100 receives a conversion parameter for a CT image as shown in FIG. 3 and generates a human spine data set as shown in FIG. 4 (S204). . 3 is a diagram illustrating an example of receiving a conversion parameter according to an embodiment of the present invention, and FIG. 4 is a diagram illustrating an example of a human spine data set generated according to an embodiment of the present invention.

In this case, the conversion parameter may include the number of horizontal and vertical pixels, the Pixel Size, and the Slice Distance. In addition, the human spine data set is a DICOM image set, for example, the six orientation settings of the image, anterior, posterior, right, left, top, and bottom may be completed. In other words, when the six directions are set, the Project File environment for creating a DICOM Image Set can be created in the Software Program.

Subsequently, the Korean human spine information production system 100 generates masking data by distinguishing the areas corresponding to the respective vertebrae from the CT images of the human spine data set with a separate color (S206).

Subsequently, the Korean human spine information production system 100 sets the HU area threshold through the confirmation of the HU value for the area desired by the user as shown in FIG. 5 in each vertebra (S208). 5 is a diagram illustrating an example of setting a threshold value by checking a profile line of a selected region according to an exemplary embodiment of the present invention.

That is, when creating the basic mask, check the HU value of the area (eg, vertebral bone) that the user wants through the profile line, and set the HU area band of the basic mask to mask the corresponding bone. To help create it.

Subsequently, the Korean human spine information production system 100 segments the image for each vertebra and generates a base mask as shown in FIG. 6 (S210). 6 is a diagram illustrating an example of a screen for generating a basic mark according to an embodiment of the present invention. The basic mask created is a mask that includes all of the neck, spine, lumbar spine, sacrum, and tailbone of the specimen, and creates a separate mask for each bone corresponding to the component (Bone Mask by ROI) to perform image segmentation. To execute.

Here, image segmentation for each vertebra is performed by removing the basic mask by copying the mask for each vertebra and removing and modifying border regions of neighboring vertebrae to clarify the image area for the vertebrae for each mask. Thus, each vertebra can have an independent mask to distinguish each vertebra.

In the project file created for each specimen, a basic mask is created that contains all the regions of the spine, from the neck to the tailbone of the specimen. Since these basic masks are not separated for each bone, they must be separated for each bone in order to create a 3D model.

Subsequently, the Korean human spine information production system 100 generates a three-dimensional model data as shown in FIG. 7 by smoothing a basic mask to represent the shape characteristics of each vertebra (S212). . 7 is a view showing an example of the 3D object of the vertebrae created in accordance with an embodiment of the present invention. Here, when the generation of 3D Objects for the vertebrae is completed, it is finally output as 3D model data of STL data format and stored.

Subsequently, the Korean human spine information production system 100 obtains numerical information of the main part representing the shape of the spine by measuring the contour of the vertebrae, measuring the cut surface, or measuring the height of the disc with respect to the 3D model data. (S214).

For example, as shown in FIG. 8, three-dimensional model data can be measured from the front, the top, and the side of the neck bone 3-7. FIG. 8 is a diagram illustrating an example of measuring dimensions 3-7 of the cervical vertebrae from three-dimensional model data according to an exemplary embodiment of the present invention. In FIG. 8, measurement parameters of the cervical vertebrae 3-7 include transverse process width (TPW), Outter maximum width of lower endplate (EPWl), maximal spinal canal depth (SCD), maximal spinal canal width (SCW), and pedicle length within PL1l. vertebral body in pedicle screw trajectory, PDAsl (Pedicle screw insertion angle), PDWl, r (Pedicle width (perpendicular to long axis) (left, right)), PDHl, r (Pedicle height (long axis) (left, right) ), Maximum uncinate process width with outer cortex (EPWuM), Interior uncinate process width with inner cortex (EPWuA), Interior uncinate process width with inner cortex (EPWuP), Upper endplate depth (EPDu), Lower endplate depth (EPDl), VBHp Including interior vertebral body height (VBHa), interior vertebral body height (VBHa), spine process length from center of upper endplate (SPL), interior disk height (ADH), center disk height (CDP), and interior disk height (PDH) do.

In addition, as shown in FIG. 9 for 3D model data, for example, the spine 1-12 dimension can be measured from above or from side. 9 is a view showing an example of measuring the spine 1-12 dimension in the three-dimensional model data according to an embodiment of the present invention. In Figure 9, the measurement parameters of the spine 1-12 is TPW (Transverse Process width), EPWuM (Maximal upper endplate width), EPWl (Maximal lower endplate width), SCD (Maximal spinal canal depth), SCW (Maximal spinal canal width) , PL1l (Pedicle length within vertebral body in pedicle screw trajectory), PL2l (Pedicle length out of vertebral body in pedicle screw trajectory), PDAsl (Pedicle screw insertion angle), PDWl, r (Pedicle width (perpendicular to long axis) (left right)), PDHl, r (Pedicle height (long axis) (left, right)), EPDu (Upper endplate depth), EPDl (Lower endplate depth), VBHp (Posterior vertebral body height), VBHa (Anterior vertebral body height) (SPL), Spinous process length from center of upper endplate, PDlt (Pedicle angle in sagittal plane), ADH (Anterior disk height), CDH (Center disk height), PDH (Position disk height), LDH (Lateral disk height at left), lateral disk height at right (RDH), and the like.

In addition, as shown in FIG. 10 with respect to the 3D model data, for example, the dimension 1-5 of the lumbar spine can be measured from the front side, the upper side, and the side. 10 is a view showing an example of measuring the dimension 1-5 of the lumbar spine in the three-dimensional model data according to an embodiment of the present invention. In FIG. 10, the measurement variables of the lumbar spine 1-5 are TPW (Transverse Process width), Maximum Upper Endplate Width (EPWuM), Maximum Lower Endplate Width (EPWl), Maximum Spinal Canal Depth (SCD), and Maximum Spinal Canal Width (SCW). ), PL1l (Pedicle length within vertebral body in pedicle screw trajectory), PL2l (Pedicle length out of vertebral body in pedicle screw trajectory), PDAsl (Pedicle screw insertion angle), PDWl, r (Pedicle width (perpendicular to long axis) ( left, right)), PDHl, r (Pedicle height (long axis) (left, right)), EPDu (Upper endplate depth), EPDl (Lower endplate depth), Interior vertebral body height (VBHp), Anterior vertebral body height), Spinal process length from center of upper endplate, PDlt (Pedicle angle in sagittal plane), ADH (Anterior disk height), CDH (Center disk height), PDH (Position disk height), LDH (Lateral disk height) at left), lateral disk height at right (RDH), and the like.

In addition, the measurement of the height of the disk is to measure the height of the disk in the sagittal plane by cutting in the median cross-section as shown in Figure 11, by cutting the coronal plane around the body center as shown in Figure 12 to measure the height of the disk in the plane can do. FIG. 11 is a diagram illustrating an example of measuring a disk height in a sagittal plane according to an embodiment of the present invention, and FIG. 12 is a diagram illustrating an example of measuring a disk height in a coronal plane according to an embodiment of the present invention. In this case, the basic unit of measurement items is length mm and angle degrees. In addition, measurements in the sagittal plane correspond to all areas of the neck, spine and lumbar spine, and measurements in the coronal plane may correspond to the spine and lumbar spine.

And, the height of the neck disk can be measured based on the corner points of the front, middle, and end of the vertebral body in the sagittal plane as shown in FIG. 13 is a view showing an example of measuring the height of the neck bone disc according to an embodiment of the present invention.

Subsequently, the Korean human spine information production system 100 cuts the bone density of the pure body portion excluding the spinal posterior region by cutting from the pedicle adjacent to the vertebral body with respect to the 3D model data based on the Hounsfield Unit (HU) value according to Equation (1). It calculates as (S216).

Here, the HU value of the body portion of the vertebrae may be calculated by cutting a pedicle of vertebral arch portion closer to the body with respect to the 3D model data. At this time, the vertebral ring portion is cut to create a new mask of the remaining vertebral trunk portion. Record the average HU value and standard deviation using the properties view function of the newly created mask.

Subsequently, the Korean human spine information production system 100 includes a spine at the same time from the first neck C1 to the sacrum to test the motion characteristics of each vertebral joint including 7 necks, 12 spines, and 5 hips. A bone density (BMD) test is performed as shown in FIG. 14 by applying Dual Energy X-ray Absorption (DEXA) to each extracted spinal joint (S218). 14 is a view showing an example of performing a bone density test on the spinal joint according to an embodiment of the present invention.

At this time, the external occipital protuberance is cut at the top, the rib is cut at least 1 cm away from the transverse process, and the lower part of the sacrum is cut at the bottom. The lower part of the first stage S1 is cut and extracted.

Here, the extraction of the spine to be used in the test should be careful not to damage the bones and major ligaments. The sacrum bone can be cut at both sides of the ala of sacrum. The removed vertebral body removes unnecessary soft tissues except the major ligaments, interverebral disk, annulus fibrosus, anterior longitudinal ligament, and posterior longitudinal ligament. The posterior longitudinal ligament, ligamentum flavum, interspinous ligament, and supraspinous ligament are preserved. In the case of the spine, the structure of the joint of the head rib portion is additionally preserved to preserve the structure in the vertebral joint pocket. However, ribs and transverse structures are removed.

Subsequently, the Korean human spine information production system 100 performs a spinal segment functional test in a pair of two vertebrae through the spinal segment functional test unit 180 (S220).

At this time, the spine functional test is to test the bending-response characteristics in each segment of motion, and the two ends of the vertebrae connected to the intervertebral disc are manufactured as a set of test bodies. In order to ensure a stable movement without fixing the test body to the tester, the upper vertebral upper end plate and the lower vertebral lower end part can be fixed with a resin containing bone cement to enable pure moment load. Mounted on the tester, as shown in Figure 15, the front bend, 폄, left bend, right bend, torsion (clockwise, counterclockwise), compressive load in order to record the angle of rotation at each load step. 15 is a view showing an example of a functional test, such as bending test or spinal disc compression test for spinal segments according to an embodiment of the present invention. At this time, in order to ensure the smooth movement of the exercise segment is adjusted so that less than half of the height of the spine trunk is fixed in the resin. To ensure a more secure fixation, screws can be inserted into the torso or ring and secured to the resin.

Subsequently, the Korean human spine information production system 100 stores the bone density test result and the functional test result in correspondence with the 3D model data (S222). In this case, the human spine information production system 100 obtains a response characteristic test value for each movement direction as a result of the test, stores the test value as a text file, and can also be expressed in a graph form if necessary.

Subsequently, the Korean human spine information production system 100 includes a test piece in which each vertebral joint composed of the neck, the spine, and the lumbar spine is extracted, the soft tissue including the muscle and the ligaments is removed, and the pedicle portion is cut close to the trunk. , The compressive strength is measured by mounting with resin so that a uniform load is applied to the upper and lower plates of the cut vertebral trunk (S224).

At this time, the Korean human spine information production system 100 measures the compressive strength by applying a load to the test body at a constant speed using a universal testing machine, but from the time the extruded force is applied (vertical torso height (average of the height of the front and rear torso) The compressive strength can be measured by applying compression by a displacement corresponding to 20 to 30% of).

Subsequently, the Korean human spine information production system 100 stores the measured compressive strength in correspondence with the 3D model data (S226).

In this case, the test results may be expressed in the form of a text file of the compression amount and the corresponding load value, or may be represented by a displacement-load graph as necessary. The result can be stored, for example, in the form sample_bdcomp.txt. In the first line of the text file you can insert descriptive text to identify the contents of the data.

As described above, according to the present invention, three-dimensional shape information about the appearance of the vertebrae and numerical information obtained by measuring specific points of the vertebral shape by performing computed tomography (CT) on the human spine of Koreans, and segmentation of the vertebral body It is possible to realize a method and system for producing Korean human spine information that enables the production of physical property information indicating functionality and compressive strength.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims and their equivalents. Only. The scope of the present invention is defined by the appended claims rather than the detailed description and all changes or modifications derived from the meaning and scope of the claims and their equivalents are to be construed as being included within the scope of the present invention do.

The present invention shows the three-dimensional shape information about the appearance of the vertebrae by the computed tomography (CT) of the human spine of the Korean, the numerical information obtained by measuring a specific point of the spine shape, and the segmental function and compressive strength of the vertebral body It can be applied to the production method and system of Korean human spine information that enables the production of property information.

100: human human spine information production system 110: image acquisition unit
120: masking data generation unit 130: basic mask generation unit
140: model data generation unit 150: numerical information acquisition unit
160: bone density test unit 170: compressive strength measurement unit

Claims (26)

In the method of producing Korean human spine information using CT images obtained by computed tomography of the human spine of the human body,
(a) receiving a conversion parameter for the CT image to generate a human spine data set;
(b) generating masking data by distinguishing a region corresponding to each vertebra from the CT image of the human vertebrae data set with a separate color;
(c) setting a HU area threshold by checking HU values for areas desired by a user in each vertebra;
(d) generating a base mask by image segmenting the respective vertebrae; And
(e) smoothing the basic mask to represent shape features of each vertebra and generating three-dimensional model data;
Method of producing Korean human spine information comprising a.
The method of claim 1,
In the step (a), the conversion parameter is a method of producing Korean human spine information, characterized in that the horizontal, vertical number of pixels, Pixel Size, Slice Distance.
The method of claim 1,
In the step (a), the human spine dataset is a method for producing Korean human spine information, characterized in that the six orientation settings of the image, Anterior, Posterior, Right, Left, Top and Bottom is completed for the image.
The method of claim 1,
In the step (d), the image segmentation for each vertebra is performed by copying the basic mask to each vertebra and copying the mask to each vertebra and clarifying the image area of the vertebra for each mask. Method of producing Korean human spine information, characterized in that to separate the respective vertebrae by removing and modifying the boundary area to have an independent mask for each vertebrae.
The method of claim 1,
(f) obtaining numerical information of the main part representing the shape of the spine with respect to the three-dimensional model data by measuring at the vertebral outline, measuring at the cutting plane, or measuring the disc height;
Method of producing Korean human spine information further comprising a.
The method of claim 5, wherein
The measurement of the height of the disk is a method for producing human spinal information, characterized in that the cutting in the median cross section to measure the height of the disk in the sagittal plane, the coronal plane to the center of the body center to measure the height of the disk in the plane.
The method according to claim 6,
The measurement on the sagittal plane corresponds to all areas of the neck, spine and lumbar spine, and the measurement on the coronal plane corresponds to the spine and lumbar spine.
The method of claim 7, wherein
The measurement of the height of the cervical disc is a method for producing human spinal information of the human body, characterized in that the height is measured based on the corner points of the front, middle, and end of the vertebral body in the sagittal plane.
The method of claim 1,
(g) calculating bone density of the pure body portion excluding the spinal posterior region by cutting at the pedicle adjacent to the vertebral body with respect to the 3D model data based on the HU value according to the following equation;
Method of producing Korean human spine information further comprising a.

The method of claim 9,
The Hu value of the body portion of the vertebrae is a method of producing Korean human spine information, characterized in that calculated by cutting a pedicle of the vertebral arch (pedicle of vertebral arch) close to the body.
The method of claim 1,
(h) performing a bone mineral density (BMD) test on each of the vertebrae by applying Dual Energy X-ray Absorption (DEXA); And
(i) storing the bone density test results in correspondence with the three-dimensional model data;
Method of producing Korean human spine information further comprising a.
The method of claim 1,
(j) further performing a spinal segment functional test in pairs of two vertebrae,
The spinal segment functional test is to test the bending-response characteristics in each segment of motion. The two vertebrae connected to the intervertebral discs are made of a set of test specimens, and the upper vertebral upper end plate and the lower vertebral end plate part. Is mounted on a tester capable of pure moment load by fixing it with a resin containing bone cement.Forward bending, shock, left bending, right bending, torsion (clockwise, counterclockwise), Method of producing Korean human spine information, characterized in that the rotation angle is recorded at each load step in the order of compression load.
The method of claim 1,
(k) For the test body in which each vertebral joint consisting of the neck, spine and lumbar spine is removed, the soft tissue containing the muscles and ligaments is removed, and the pedicle portion is cut close to the trunk, above and below the cut vertebral torso. Measuring compressive strength by mounting with resin to apply a uniform load to the plate; And
(l) storing the measured compressive strength in correspondence with the three-dimensional model data;
Method of producing Korean human spine information further comprising a.
The method of claim 13,
In the step (k), the compressive strength is measured by applying a load to the test body at a constant speed using a universal testing machine, and 20 to 30 of the height of the spinal torso (an average of the front and rear torso heights) from the time when the extrusion force is applied. A method of producing Korean human spine information, characterized in that the compressive strength is measured by applying compression by a displacement equal to%.
CT image acquisition unit for obtaining a CT image by computed tomography of the spine of the human body;
Generate a human spine data set by receiving a conversion parameter for the CT image, and generate masking data by distinguishing a region corresponding to each vertebra in a CT image of the human spine data set by a separate color. A masking data generator;
A base mask generation unit for generating a base mask by setting a HU region threshold by checking a HU value for a region desired by the user in each vertebra and segmenting the image for each vertebra. ;
A model data generation unit for generating three-dimensional model data by smoothing the basic mask to represent the shape characteristics of each vertebra;
Numerical information acquisition unit for obtaining the numerical information of the main portion representing the shape of the spine with respect to the three-dimensional model data in the vertebrae outline, measured in the cutting plane or by measuring the height of the disk;
A bone density calculator for cutting the 3D model data from a pedicle adjacent to the vertebral body and calculating a bone density (ρ) of the pure body portion excluding the spinal posterior region based on the HU value;
Each vertebral joint consisting of the neck, spine, and lumbar spine is extracted, and bone mineral density (BMD) tests are performed on the extracted vertebral joints by applying Dual Energy X-ray Absorption (DEXA). A bone density measuring unit configured to store the bone density test result in correspondence with the 3D model data;
Spinal segment functional test unit for performing a spinal segment functional test in a pair of the two extracted vertebrae; And
Each vertebral joint consisting of the neck, spine and lumbar spine is removed, the soft tissues including muscles and ligaments are removed, and the pedicle part is cut close to the trunk, and uniformly on the upper and lower plates of the cut vertebral trunk. A compressive strength measuring unit which mounts with a resin to apply a load to measure compressive strength, and stores the measured compressive strength in correspondence with the three-dimensional model data;
Korean human spine information production system comprising a.
The method of claim 15,
The conversion parameter is a human body spinal column production system, characterized in that it comprises a horizontal, vertical number of pixels, Pixel Size, Slice Distance.
The method of claim 15,
The human spine data set is a Korean human spine information production system, characterized in that the six orientation settings of the image is completed, Anterior, Posterior, Right, Left, Top and Bottom.
The method of claim 15,
The image segmentation for each vertebra is performed by removing the basic mask by copying the mask for each vertebra and removing and modifying boundary regions of neighboring vertebrae in order to clarify the image area of the vertebra for each mask. Korean human spine information system, characterized in that to distinguish each of the vertebrae by having a separate mask for each vertebrae.
The method of claim 15,
The measurement of the height of the disk of the numerical information acquisition unit measures the height of the disc at the sagittal plane by cutting at the median cross section, and measures the height of the disc at the corresponding plane by cutting the coronal plane around the body center. Production system.
The method of claim 19,
The measurement in the sagittal plane corresponds to all areas of the neck, spine and lumbar spine, and the measurement in the coronal plane corresponds to the spine and lumbar spine.
21. The method of claim 20,
The measurement of the height of the neck bone disc is the production system of the human body spinal information of Korean characterized in that the height is measured based on the corner points of the front, middle, and end of the vertebral body in the sagittal plane.
The method of claim 15,
The bone density calculation unit, the human body spinal information of the three-dimensional model data by cutting in the pedicle adjacent to the vertebral body and calculates the bone density of the pure body portion excluding the spinal condyle region based on the HU value according to the following equation Production system.

23. The method of claim 22,
The Hu value of the body portion of the vertebrae is produced by cutting a pedicle of the vertebral (pedicle of vertebral arch) portion close to the body of the human body spine information production system.
The method of claim 15,
The bone density measuring unit performs a bone mineral density (BMD) test by applying dual energy X-ray absorption (DEXA) to each of the extracted vertebral joints, and calculates the bone density test result by the 3D model. Korean human spine information production system, characterized in that for storing in correspondence with data.
The method of claim 15,
The spinal segment functional test unit, the two vertebrae connected to the intervertebral discs are made of a set of test specimens, and the upper vertebral upper end plate and the lower vertebral lower end plate part are fixed with a resin including bone cement. Equipped with a tester capable of pure moment load, recording the angle of rotation at each load step by applying forward bending, shock, left bending, right bending, clockwise or counterclockwise torsion, and compression load Korean human spine information production system.
The method of claim 15,
The compressive strength measuring unit measures the compressive strength by applying a load to the test body at a constant speed using a universal testing machine, but 20 to 30 of the height of the spinal torso (an average of the front and rear torso height) from the time the extruded force is applied Korean human spine information production system characterized in that the compressive strength is measured by applying a compression amount corresponding to%.

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