KR101261751B1 - Cosmetic composition for sunscreen and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising an oil-soluble compound having an absorption peak at 290 nm to 400 nm and a hydrated lecithin as an active ingredient, and a method for producing the same, and more particularly to a cosmetic composition comprising the hydrated lecithin and the oil- Soluble compound having an ultraviolet blocking effect and an ultraviolet barrier index, and a method for producing the same.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to cosmetic compositions,

The present invention relates to a cosmetic composition comprising a lipophilic compound having an absorption peak at 290 nm to 400 nm and hydrated lecithin as an active ingredient, and a process for producing the same.

UVA and UVB among ultraviolet rays reach directly to the skin, causing erythema, blackening, skin cancer and the like, and it is a major cause of skin aging. Since human skin is often exposed to such ultraviolet rays, ultraviolet ray blocking agents for protecting the skin from ultraviolet rays have been actively developed.

In the development of ultraviolet screening agents having a high ultraviolet barrier property, it is important to maintain a high level of the oil-soluble compound having an effect of ultraviolet ray shielding and uniformly disperse in the cosmetic material. However, the oil-soluble compound exhibiting an ultraviolet shielding effect is not compatible with the moisturizing agent, vegetable oil, glyceride-based oil and the like used in cosmetics. Therefore, when the emulsion is applied to crystals, it is precipitated as crystals, and the precipitated crystals lose the stability of emulsification and have a great limitation in application to cosmetics.

It is an object of the present invention to provide a cosmetic composition and a method for producing the cosmetic composition which increase the solubility of a fat-soluble compound exhibiting an ultraviolet shielding effect and have an excellent ultraviolet barrier property.

In order to achieve the above object, the present invention provides a cosmetic composition comprising a lipophilic compound having an absorption peak at 290 nm to 400 nm and hydrated lecithin as an active ingredient.

Further comprising heating a solution containing a lipophilic compound having an absorption peak at 290 nm to 400 nm and a hydrated lecithin to 75 to 95 DEG C and stirring with a mixer, wherein the lipophilic compound forms a lipid structure A method for producing a cosmetic composition is provided.

The cosmetic composition of the present invention exhibits an excellent effect for increasing the solubility of the oil-soluble compound exhibiting the ultraviolet blocking effect and improving the ultraviolet barrier property.

Further, the production method of the present invention has a beneficial effect for forming the lipid structure of the above-mentioned fat-soluble compound.

FIG. 1 (A) is a photograph of the precipitation of Example 1, and FIG. 1 (B) is a photograph of the precipitation of Comparative Example 1.
2 is a DSC graph of a composition containing hydrated lecithin and a composition not containing it.
FIG. 3 is a photograph of bis-ethylhexyloxy phenolmethoxyphenyltriazine (Bis-Ethylhexyloxy phenolmethoxyphenyltriazine) obtained by lipidation using hydrated lecithin and then photographed with an optical microscope.

The present invention provides a cosmetic composition comprising a lipophilic compound having an absorption peak at 290 nm to 400 nm and a hydrated lecithin as an active ingredient.

The present invention also provides a method for preparing a cosmetic composition comprising heating a solution containing a lipophilic compound having an absorption peak at 290 nm to 400 nm and a hydrated lecithin to 75 to 95 캜 and stirring with a mixer.

In addition, the method for preparing the composition is characterized in that a lipid-soluble compound that exhibits an ultraviolet blocking effect forms a lipid structure.

Hereinafter, the present invention will be described in detail.

UV protection Cosmetics  Composition

The cosmetic composition of the present invention comprises a fat-soluble compound having an absorption peak at 290 nm to 400 nm.

The above-mentioned oil-soluble compounds include bis-ethylhexyloxy phenolmethoxyphenyltriazine (BEMT), octylmethoxycinnamate, octyl salicylate, octocrylene, butylmethoxydibenzoylmethane, oxy Benzene, octyltriazone, menthyl anthranilate and 3,4-methyl benzylidene camphor can be used in combination. Most preferably, the fat soluble compound comprises a BEMT. The BEMT forms a lipid structure by binding with hydrated lecithin, thereby increasing the solubility and having a high ultraviolet barrier property.

The BEMT is a heterocyclic compound, specifically represented by the following formula (1). The BEMT is composed of benzophenone, benzotriazole, and hydroxyphenyltriazine.

[Chemical Formula 1]

The BEMT molecules are completely cross-linked around triazine, and have an absorption peak at 290 nm to 400 nm, and can be applied to a cosmetic composition having excellent ultraviolet shielding ability by simultaneously absorbing a UVA region and a UVB region.

In the cosmetic composition of the present invention, the content of the oil-soluble compound as the active ingredient may be appropriately used in the range of 0.1 to 10% by weight, preferably 1 to 3% by weight, based on the total weight of the composition. If the content is less than 0.1% by weight, there is no significant effect. If the content is more than 10% by weight, there is no marked increase in the effect due to the increase of the content.

The cosmetic composition of the present invention also includes hydrated lecithin.

The hydrated lecithin, which is contained together with the lipophilic compound having an absorption peak at 290 nm to 400 nm, is dissolved in alcohol and ether, and emulsified with water. The hydrated lecithin is a pale yellow transparent or semitransparent viscous liquid and has a weakly peculiar odor. Since hydrated lecithin is a component of the cell membrane, it is very useful in the living body and is not useful in other cosmetic raw materials. In addition, hydrated lecithin has a surfactant action because it is an amphiphilic structure having two alkyl groups in the same molecule and a polar group having a high affinity for water.

However, while ordinary surfactants dissolve in water to form micelles, they are not soluble in water in the case of hydrated lecithin, but they are dispersed as an endoplasmic reticulum having a bimolecular membrane structure when diluted with a large amount of water.

Thus, by using hydrated lecithin liposomes, water-soluble components and oil-soluble components can be contained in the same endoplasmic reticulum. The hydrated lecithin improves the emulsification stability of the oil-soluble compound having an ultraviolet blocking effect, and can preferably maximize the dispersibility of the BEMT.

In addition, the content of hydrated lecithin in the cosmetic composition of the present invention is preferably 0.1 to 10% by weight based on the total weight of the composition. If the content is less than 0.1% by weight, there is a problem that ultraviolet ray shielding effect can not be expected. If the content is more than 10% by weight, a synergistic effect of ultraviolet ray shielding can not be obtained.

The ingredients contained in the cosmetic composition of the present invention include the ingredients conventionally used in the composition other than the above-mentioned effective ingredients, and include conventional additives such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers do. The additives such as other humectants, emulsifiers, emulsifiers, skin protectants, preservatives, viscosity regulators and the like may be 80 to 90% by weight based on the total weight of the composition.

As the water-soluble vitamin, any of water-soluble vitamins may be used as long as it can be compounded in cosmetics, but preferably vitamin B 1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H (Sodium thiamine hydrochloride, sodium ascorbate, etc.) and derivatives (sodium ascorbic acid-2-phosphate, magnesium ascorbic acid-2-phosphate etc.) can also be used in the present invention It is included in water-soluble vitamins. The water-soluble vitamin can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzymatic method, or a chemical synthesis method.

Vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-delta tocopherol), and the like can be used as the useful vitamins, , And derivatives thereof (such as palmitic acid ascorbin, ascorbic acid stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, Ethyl ether, etc.) and the like are also included in the usable vitamins used in the present invention. Usability Vitamins can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzyme or a chemical synthesis method.

Examples of the moisturizing agent include water-soluble low-molecular moisturizing agents, oil-soluble molecular moisturizing agents, water-soluble polymers, and oil-soluble polymers. Examples of the water-soluble low-molecular moisturizing agent include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone-carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol Glycol (polymerization degree n = 2 or more), polyglycerin (polymerization degree n = 2 or more), lactic acid, lactic acid salt and the like. Examples of the lipid-soluble low-molecular moisturizing agent include cholesterol and cholesterol ester. Examples of the water-soluble polymer include carboxyvinyl polymer, polyaspartic acid, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, etc. .

Examples of the oil-soluble polymer include polyvinylpyrrolidone / eicosene copolymer, polyvinylpyrrolidone / hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and polymer silicone.

The cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art and can be formulated into an aqueous or oily solution, a suspension, an emulsion, a paste, a cream or an aqueous gel or an oily gel, It is not limited. More specifically, the present invention relates to a composition for the treatment of sunscreen, supple lotion, convergent lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, book, spray, powder, sun lotion, sun spray, sun gel, .

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

UV protection Cosmetics  Method for producing a composition

The method for producing a cosmetic composition of the present invention comprises the step of heating a solution containing a lipophilic compound having an ultraviolet blocking effect and a hydrated lecithin to 75 to 95 캜 and stirring the mixture with a mixer, wherein the lipophilic compound forms a lipid structure .

The lipid structure refers to a structure in which the hydrated lecithin is located between the emulsified ultraviolet screening agents. That is, phosphatidylethanolamine, phosphatidyl choline, phosphatidylserine, and N-acyl phosphatidylethanolamine of the hydrated lecithin are bonded to terminal groups of bis-ethylhexyloxyphenol methoxyphenyltriazine, which is a lean body, to form a fluid lipid structure do.

According to the production method of the present invention, the linkage of the oil-soluble compound having an absorption peak at 290 nm and 400 nm with the hydrated lecithin forms a lipid structure, whereby the solubility of the oil-soluble compound having an ultraviolet blocking effect is increased and the ultraviolet barrier property It is effective. In addition, a cosmetic composition which improves the emulsification stability of the above-mentioned oil-soluble compound, and preferably maximizes the dispersibility of the BEMT, is provided.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. It should be understood, however, that these examples and comparative examples are provided only for illustrative purposes in order to facilitate understanding of the present invention, but the scope and scope of the present invention are not limited by the following examples.

< Example  And Comparative Example >

< Example  1> BEMT and Hydrated lecithin  Manufacture of sunscreen containing 2%

The cosmetic composition for UV-screening of Example 1, constituted by ingredients and contents as shown in the following Table 1, was prepared. The A-phase was heated to 80 ° C and the homo-mixer was stirred at 3000 rpm for 10 minutes. The A-phase and the B-phase were heated to 80 ° C respectively and the B-phase was added to the A-phase and stirred at 3000 rpm for 5 minutes. The next C phase was added and the homo mixer was stirred at 3000 rpm for 3 minutes. After cooled to 45 ° C, D-phase was added, and Homo Mixer was stirred at 1500 rpm for 1 minute.

Prize Raw material name content(%) A Distilled water 79 Bis-ethylhexyloxyphenol methoxyphenyltriazine 2.0 Hydrated lecithin 2.0 B Ethyl hexylmethoxycinnamate
(Ethylhexyl Methoxycinnamate) 5 Titanium oxide (TiO2) 1.5 Hydrogenated polyisobutene
(Hydrogenated polyisobutene) 5 PEG-40 stearate (PEG-40 Stearate) 1.5 Stearic acid One Sorbitan stearate One C Sodium acryloyldimethyltaurate copolymer
(Sodium acrylate / sodium acryloyldimethyl taurate copolymer), isohexadecane, polysorbate 80 (Polysorbate 80) One D But are not limited to, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, One

< Example  2> BEMT and Hydrated lecithin  Manufacture of sunscreen containing 2%

The procedure of Example 1 was repeated except that isoamyl p-methoxycinnamate was added to the phase B and the content of each raw material was adjusted as shown in Table 2 below.

Prize Raw material name content(%) A Distilled water 75.5 Bis-ethylhexyloxyphenol methoxyphenyltriazine 2.0 Hydrated lecithin 2.0 B Isoamyl p-methoxycinnamate (Isoamyl p-methoxycinnamate) 8 Diethylaminohydroxybenzoylhexylbenzoate
(Diethylaminohydroxybenzoyl hexyl benzoate) 2 Hydrogenated polyisobutene &lt; RTI ID = 0.0 &gt; 5 PEG-40 stearate (PEG-40 Stearate) 1.5 Stearic acid One Sorbitan stearate One C Sodium acryloyldimethyltaurate copolymer
(Sodium acrylate / sodium acryloyldimethyl taurate copolymer), isohexadecane, polysorbate 80 (Polysorbate 80) One D But are not limited to, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, One

< Comparative Example  1> BEMT  Manufacture of sunscreen containing 2%

A cosmetic composition for UV-screening of Comparative Example 1 comprising the components and contents as shown in the following Table 3 was prepared.

The A and B phases were heated to 80 ° C and the B phase was put in phase A, and the mixture was stirred for 5 minutes at 3000 rpm in a Homo Mixer. The next C phase was added and the homo mixer was stirred at 3000 rpm for 3 minutes. After cooled to 45 ° C, D-phase was added, and Homo Mixer was stirred at 1500 rpm for 1 minute.

Prize Raw material name content(%) A Distilled water 81 B Bis-ethylhexyloxyphenol methoxyphenyltriazine 2 Ethyl hexylmethoxycinnamate
(Ethylhexyl Methoxycinnamate) 5 Titanium oxide (TiO2) 1.5 Hydrogenated polyisobutene
(Hydrogenated polyisobutene) 5 PEG-40 stearate (PEG-40 Stearate) 1.5 Stearic acid One Sorbitan stearate One C Sodium acryloyldimethyltaurate copolymer
(Sodium acrylate / sodium acryloyldimethyl taurate copolymer), isohexadecane, polysorbate 80 (Polysorbate 80) One D But are not limited to, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, One

< Comparative Example  2> BEMT  Manufacture of sunscreen containing 2%

Except that isoamyl p-methoxycinnamate was added to the phase B and the content of each substance was controlled as described in Table 4 below.

Prize Raw material name content(%) A Distilled water 77.5 B Bis-ethylhexyloxyphenol methoxyphenyltriazine 2 Isoamyl p-methoxycinnamate (Isoamyl p-methoxycinnamate) 8 Diethylaminohydroxybenzoylhexylbenzoate
(Diethylaminohydroxybenzoyl hexyl benzoate) 2 Hydrogenated polyisobutene &lt; RTI ID = 0.0 &gt; 5 PEG-40 stearate (PEG-40 Stearate) 1.5 Stearic acid One Sorbitan stearate One C Sodium acryloyldimethyltaurate copolymer
(Sodium acrylate / sodium acryloyldimethyl taurate copolymer), isohexadecane, polysorbate 80 (Polysorbate 80) One D But are not limited to, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, One

< Comparative Example 3 >

Experiments were carried out on commercially available sunscreen products. The product used is the "Natural Sun AQ Super White Sunflower SPF50 +, PA +++" from The Face Shop, the ingredients of which are Strawberry Pine Bark Extract, Ethylhexyl Salicylate, Titanium Oxide, Butyl Methoxybenzylmethane, 4-methylbenzylidene camphor, isoamyl p-methoxycinnamate, manganese bark extract, licorice extract, aloe leaf extract, bell pepper root / stem / branch extract, Extract, methylparaben, and potassium hydroxide.

 < Experimental Example  1> BEMT Of Solubility

The solubility of the BEMT prepared by the method of Example 1 and Comparative Example 1 was evaluated. As shown in Fig. 1, the ultraviolet screening agent (A) containing hydrated lecithin was less precipitated than the ultraviolet screening agent (B) containing only the BEMT, BEMT was found to be more soluble when it was added together with hydrated lecithin.

 < Experimental Example  2> UV protection index comparison

The UV-blocking index of the BEMT-containing compositions prepared by the methods of Examples 1 and 2 and Comparative Examples 1 and 2 was tested in-vitro. As a result, as shown in Table 5, the ultraviolet screening agents containing hydrated lecithin (Examples 1 and 2) showed a higher Sun Protection Factor (SPF) than the ultraviolet screening agents containing only BEMT (Comparative Examples 1 and 2) ) And PFA (Protection Factor of UVA).

Comparative Example 3 was tested with commercially available commercial products.

division Formulation application sample result chief ingredient content SPF PFA Example 1 Bis-ethylhexyloxyphenol methoxyphenyltriazine
Ethyl hexylmethoxycinnamate
Titanium oxide 2.00%
5.00%
1.50% 35 14 Example 2 Bis-ethylhexyloxyphenol methoxyphenyltriazine
Isoamyl p-methoxy cinnamate
Diethylaminohydroxybenzoylhexylbenzoate 2.00%
2.00%
8.00% 38 12 Comparative Example 1 Bis-ethylhexyloxyphenol methoxyphenyltriazine
Ethyl hexylmethoxycinnamate
Titanium oxide 2.00%
5.00%
1.50% 26 9 Comparative Example 2 Bis-ethylhexyloxyphenol methoxyphenyltriazine
Isoamyl p-methoxy cinnamate
Diethylaminohydroxybenzoylhexylbenzoate 2.00%
2.00%
8.00% 26 11 Comparative Example 3 The Face Shop Natural Line AQ Super White Sunscreen (SPF50 +, PA +++) Unknown 29 11

Comparison of UV blocking indexes of Examples and Comparative Examples

< Experimental Example  3> BEMT of DSC  Measure

DSC graphs were analyzed to determine the phase transition temperature of the BEMT-containing compositions of the present invention. As a result, as shown in FIG. 2, the temperature at which the BEMT phase-transitions to the liquid phase is 79.62 ° C., whereas the temperature at which the BEMT containing hydrated lecithin phase-transitions to the liquid phase is 71.31 ° C. I could confirm.

That is, in order to increase the solubility of the BEMT in the process of preparing the BEMT-containing composition, the process temperature is maintained at about 80 캜. Since the BEMT has a similar phase transition temperature to the phase transition temperature, The phase transition temperature was lowered and the solubility was remarkably improved.

< Experimental Example  4> Lipid  Structure Whether or not formed  observe

Fig. 3 (a) shows the one day after the water dispersion at room temperature (25 캜), and Fig. 3 (b) shows the water dispersion after 90 days after the water dispersion at room temperature (25 캜). This is because when the hydrated lecithin is positioned between the BEMTs it forms a close-packed structure and the phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine and N-acylphosphatidylethanolamine of lecithin bind to the terminal group of the lean material It was shown that the BEMT was stable without recrystallization and agglomeration even when dispersed in water phase by forming a lipid structure.

Claims (8)

A cosmetic composition comprising a lipid structure formed by binding an hydrated lecithin to a terminal end of bis-ethylhexyloxyphenol methoxyphenyltriazine having an ultraviolet blocking effect by having an absorption peak at 290 to 400 nm as an active ingredient.
delete The method according to claim 1,
Wherein the hydrated lecithin is 0.1 to 10% by weight based on the total weight of the cosmetic composition.
The method according to claim 1,
Wherein the bis-ethylhexyloxyphenol methoxyphenyltriazine is present in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.
Ethylhexyloxyphenol methoxyphenyltriazine having an ultraviolet blocking effect by having an absorption peak at 290 to 400 nm and a hydrated lecithin is heated to 75 to 95 DEG C and stirred with a mixer,
Wherein the bis-ethylhexyloxyphenol methoxyphenyltriazine and the hydrated lecithin in the step described above form a lipid structure by bonding hydrated lecithin to the terminal group of bis-ethylhexyloxyphenol methoxyphenyltriazine. Gt;
delete The method of claim 5, wherein
Wherein the hydrated lecithin is present in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.
6. The method of claim 5,
Wherein the bis-ethylhexyloxyphenol methoxyphenyltriazine is present in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

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