KR101258696B1 - Health Suppliment Food Comprising Powder of Angelica Keiskei With Antioxdative Activity And Manufacturing Method Thereof - Google Patents

Abstract

The present invention relates to a health supplement comprising a fresh vinegar powder having an antioxidant activity and a manufacturing method thereof, and to a health supplement having an antioxidant activity including a fresh vinegar powder.
According to the present invention, the hydrophilic and lipophilic antioxidant components contained in fresh vinegar are excellent in the absorption rate and bioavailability in vivo, thereby providing a health supplement with high antioxidant activity enhancing effect.

Description

Health Suppliment Food Comprising Powder of Angelica Keiskei With Antioxdative Activity And Manufacturing Method Thereof}

The present invention relates to a health supplement food having an antioxidant activity, including fresh vinegar powder, and a preparation method thereof.

The human body continuously generates free radicals during normal metabolic processes. When these free radicals accumulate in the body, they cause oxidative damage to polyunsaturated fatty acids, amino acids, DNA, etc. in the body, which leads to aging, obesity, diabetes, and heart. It can lead to chronic diseases related to oxidative stress, such as disease, cataracts, and macular degeneration.

Antioxidant nutrients act to eliminate free radicals, thereby defending the accumulation of excess free radicals in the body, and can prevent or delay oxidative damage (stress) and related chronic diseases.

On the other hand, in large-scale intervention trials in which single antioxidant nutrients such as beta-carotene or vitamin E, or these antioxidant nutrients have been ingested in complex oxidative stress groups, surprisingly large amounts of single antioxidant nutrients are consumed. Rather, it has been reported to increase the incidence and mortality of cancer or heart disease. Therefore, the human body's antioxidant defense system is not by a single nutrient but a well-balanced fat-soluble and water-soluble antioxidant nutrient can work optimally, there is a risk of toxicity when ingesting a single nutrient in excess.

Shinseoncho (神仙 草; Angelica keiskei ( also known as dayflower , new herb) is a perennial plant originated in Japan and has been considered a medically important herb in Asia. In animal experiments with extracts of fresh vinegar, the fresh vinegar extract has been reported to inhibit gastric acid secretion, prevent cancer, and prevent hypertension. However, there is no case that the antioxidant function of fresh vinegar is revealed in the human body. In addition, no changes in the absorption kinetic or antioxidant function of antioxidant nutrients in the body after physiological intake of fresh vinegar have been reported.

The main carotenoids contained in fresh vinegar are beta-carotene and lutein, which have the effect of converting to vitamin A and antioxidant effects. Inverse correlations have been reported. Lutein is a major constituent of the ocular macula and is the only carotenoid found in the ocular lens. It is known to prevent eye diseases such as macular degeneration and cataracts. Fresh vinegar is also rich in vitamin C. Vitamin C is an essential nutrient that acts as a cofactor of many enzymes. It is known as an effective antioxidant nutrient because of its excellent electron donating ability and regenerative ability. Population uptake of vitamin C has been shown to reduce the risk of many chronic diseases, such as heart disease, cancer, eye disease and degenerative brain disease. Fresh vinegar is also rich in polyphenols, such as quasi-tin. Animal and human cell cultures have shown that polyphenols prevent cardiovascular disease, cancer, degenerative brain disease, diabetes and osteoporosis. In addition, antioxidant and anti-inflammatory properties are expected to have beneficial effects on other chronic diseases, including oxidative stress and inflammation, such as rheumatoid arthritis and chronic obstructive pulmonary disease.

The present inventors have conducted studies on the major nutrients of fresh vinegar and found that the fresh vinegar contains a large amount of antioxidant carotenoids, vitamin C and phenol, and is also rich in chalcones, which have functions to regulate blood sugar and blood fat, It was found that the antioxidant activity of these fresh vinegar is very good. Accordingly, using the fresh vinegar has been developed a health supplement food with a high antioxidant effect without any side effects.

The present invention is to provide a dietary supplement and a method for preparing a health supplement having antioxidant activity, including fresh vinegar powder.

The present invention is to provide a health supplement with high anti-oxidation enhancing effect with excellent in vivo absorption rate and bioavailability of the hydrophilic and lipophilic antioxidant components contained in fresh vinegar without side effects.

The present invention for achieving the above object provides a dietary supplement with antioxidant activity, including fresh vinegar powder.

In addition, the fresh vinegar powder provides a health supplement with antioxidant activity that is prepared according to the vacuum freeze drying method.

In addition, the size of the fresh vinegar powder provides a dietary supplement with antioxidant activity, characterized in that 50 to 250 mesh.

In addition, it provides a health supplement with antioxidant activity that comprises the fresh vinegar powder in an amount of 0.5 to 30% by weight.

The present invention also provides a dietary supplement having antioxidant activity further containing a foodstuff acceptable dietary supplement.

In addition, it provides a dietary supplement with antioxidant activity in the form of powder, granules, tablets, capsules, beverages or bread.

In addition, 10-20% by weight of fresh vinegar powder, 10-20% by weight of rice flour, 5-10% by weight of caramel pigment, 25-30% by weight of Macion syrup, 10-15% by weight fructose, 10-15% by weight of glucose, maltodextrin It provides a dietary supplement with antioxidant activity comprising 1 to 5% by weight, sunflower seed oil 3 to 10% by weight, lecithin 0.05 to 1% by weight.

The invention also, (S1) washing and cutting the fresh vinegar; (S2) freezing the cut fresh vinegar; (S3) drying the frozen fresh vinegar; And (S4) provides a method for producing a dietary supplement with antioxidant activity comprising the step of crushing the dried fresh vinegar.

In addition, (S2) step provides a method for producing a dietary supplement with antioxidant activity that is performed for 12 to 36 hours at -80 ℃ ~ -40 ℃.

In addition, (S3) step provides a method for producing a dietary supplement with antioxidant activity that is performed for 35 to 38 hours at 45 ℃ ~ 48 ℃.

In addition, (S4) step provides a method of producing a dietary supplement with antioxidant activity that is carried out in a condition of 60% ~ 65% humidity is controlled.

Hereinafter, the present invention will be described in more detail.

According to the present invention, the hydrophilic and lipophilic antioxidant components (nutrients) contained in fresh vinegar are excellent in the absorption rate and bioavailability of the present invention can provide a health supplement food with high antioxidant activity enhancing effect.

These dietary supplements increase the blood levels of antioxidant nutrients and the body's antioxidant function in normal as well as metabolic syndrome patients with high oxidative stress. It may be used for the reduction of oxidative stress and antioxidant function of patients with diseases such as oxidative stress, obesity and chronic diseases.

1 is a schematic diagram showing a manufacturing process of the health supplement according to an embodiment of the present invention,
Figure 2a is a graph showing the content of the lipophilic antioxidant component of each fresh vinegar extract with different extraction conditions in accordance with an experimental example of the present invention, Figure 2b is the content of the hydrophilic antioxidant component of each fresh vinegar extract with different extraction conditions Is a graph representing
Figure 3 is a graph showing the stability according to the storage temperature of the antioxidant component contained in fresh vinegar powder according to an experimental example of the present invention, Figure 3a is lutein (Lutein), Figure 3b is trans beta-carotene (trans β-carotene) 3c is a 9-cis beta-carotene (9-cis β-carotene), 3d is a graph for total phenols,
Figure 4a is a graph showing the change in the content of quasi-citin in the blood of a normal healthy person after intake of a dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 4b is a blood of the patient of metabolic syndrome after intake of the dietary supplement It is a graph showing the change of the quasi-tin content in
Figure 5a is a graph showing the beta-carotene absorption kinetic in the blood of the normal health person after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 5b is normal health after intake of the dietary supplement Graph showing phosphorus lutein absorption kinetics,
Figure 6a is a graph showing the beta-carotene absorption kinetics in the blood of the metabolic syndrome patient after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 5b is a metabolic syndrome after intake of the dietary supplement Is a graph showing the absorption kinetic of lutein in the patient,
Figure 7a is a graph showing the antioxidant function kinetics in the blood of normal healthy people after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 7b is a metabolic syndrome patient after the dietary supplement intake It is a graph showing the antioxidant function kinetics in the blood.

The present invention relates to a health supplement having antioxidant activity, including fresh vinegar powder.

Fresh vinegar according to the present invention is preferably to use the leaves and the stem part.

In addition, when the fresh vinegar is extracted with alcohol such as water or ethanol, the extraction efficiency of fat-soluble antioxidant nutrients is low, so that loss of nutrients occurs, and it is preferable to prepare the powder by vacuum freeze drying. More specifically, the fresh vinegar powder of the present invention is prepared by freezing the fresh vinegar for 12-36 hours at -80 ℃ ~ -40 ℃, vacuum dried at 45 ℃ ~ 48 ℃ for 35 to 38 hours and then pulverized Do. In addition, when pulverizing the fresh lyophilized fresh vinegar, it is preferable to grind in a state where the humidity is controlled to 60% to 65% in order to prevent moisture absorption. The vacuum freeze drying conditions as described above are preferable to minimize nutrient destruction and to improve the in vivo absorption rate and bioavailability efficiency of antioxidant nutrients contained in fresh vinegar.

The fresh vinegar powder is preferably 50 to 250 mesh size, more preferably 80 mesh size. If the size of the powder is too small, it is not economical. If the powder is too large, the texture may be poor.

And, the content of fresh vinegar powder contained in the health supplement of the present invention is preferably 0.5 to 30% by weight. In order to express the antioxidant efficacy of fresh vinegar powder is preferably in the above content range. In addition, it is preferable that the dietary supplement according to the present invention contains fresh vinegar powder in an amount of 3 g to 6 g, which is a proper daily intake.

The health supplement of the present invention can be prepared in the form of powder, granules, tablets, capsules, beverages or bread. Further, in the process of preparing the health supplement food in the above form, in addition to the fresh vinegar powder, it may further contain food acceptable additives such as sugars, pigments.

As a preferred embodiment of the health supplement according to the present invention 10 to 20% by weight of fresh vinegar powder, 10 to 20% by weight of rice powder, 5 to 10% by weight of caramel pigment, 25 to 30% by weight of maion starch syrup, 10 to 15 fructose There is a dietary supplement in the form of a tablet containing 10% to 15% by weight of glucose, 1 to 5% by weight of maltodextrin, 3 to 10% by weight of sunflower seed oil, and 0.05 to 1% by weight of lecithin. Such supplements are not only high in antioxidant capacity, but can be easily taken in everyday life.

The health supplement according to the present invention is excellent in the absorption rate and bioavailability efficiency of the hydrophilic and lipophilic antioxidant components contained in fresh vinegar and has a high antioxidant activity enhancing effect. These dietary supplements increase the blood levels of antioxidant nutrients and the body's antioxidant function in normal as well as metabolic syndrome patients with high oxidative stress, and thus elevate oxidative stress in elderly people, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease and dementia. Patients with diseases caused by oxidative stress, such as obesity and chronic diseases can be used for reducing the oxidative stress and antioxidant function. In addition, the dietary supplement according to the present invention may be effective in preventing and improving various diseases related to metabolic syndrome.

Next, the present invention (S1) washing and cutting the fresh vinegar; (S2) freezing the cut fresh vinegar; (S3) drying the frozen fresh vinegar; And (S4) provides a method for producing a dietary supplement with antioxidant activity comprising the step of crushing the dried fresh vinegar.

At this time, fresh vinegar freezing conditions of step (S2), fresh vinegar drying conditions of step (S3), fresh vinegar grinding conditions of step (S4) are as described above.

Hereinafter, the configuration of the present invention in more detail with reference to the drawings and examples, but the scope of the present invention is not limited to the following examples.

Example

A manufacturing process of the dietary supplement containing fresh vinegar powder will be described with reference to FIG. 1.

First, the leaves and leaf stems of fresh vines were harvested, inspected, selected and washed three times with fresh portions. The washed fresh vinegar was cut to a suitable size and then frozen at −65 ° C. for 24 hours, and vacuum dried at 46 ° C. for 36 hours. The dried fresh vinegar was pulverized in a humidity environment of 63% to prevent moisture absorption to prepare a fresh mesh powder of 80 mesh size.

Then, 45.2% by weight of Macion syrup, 20.3% by weight fructose, 20.3% by weight glucose, 6.2% by weight maltodextrin, 7.84% by weight sunflower seed oil and 0.16% by weight of lecithin were added to a mixing tank to prepare a sugar solution. After mixing 91.43% by weight of the prepared sugar solution and 8.57% by weight of caramel pigment, 70% by weight of the sugar-mixed sugar solution was mixed with 15% by weight of rice flour and 15% by weight of the prepared fresh vinegar powder to prepare a dietary supplement. It was.

The dietary supplement is 28.9% by weight Macion syrup, 15% by weight fructose, 13% by weight glucose, 4% by weight maltodextrin, 5% by weight sunflower seed oil, 0.1% by weight lecithin, 6% by weight caramel pigment, 15% by weight rice flour And 15% by weight of fresh vinegar powder according to the present invention, and contains 5 g of a proper intake amount of fresh vinegar powder per day.

Experimental Example  1: Feasibility of using fresh vinegar powder and stability according to storage temperature

In order to compare the extraction efficiency of antioxidant nutrients contained in fresh vinegar, fresh vinegar was extracted with 100wt% water, 40wt% ethanol, 70wt% ethanol.

Figure 2a is a graph showing the content of the lipophilic antioxidant component of each fresh vinegar extract with different extraction conditions, Figure 2b is a graph showing the content of the hydrophilic antioxidant component of each fresh vinegar extract with different extraction conditions. As shown in FIG. 2, when the fresh vinegar was extracted with 100 wt% of water, the fat-soluble carotenoid was not extracted. When extracted with 70 wt% ethanol, the extraction efficiency of fat-soluble antioxidant nutrients contained in fresh vinegar was low. Specifically, only 46% of lutein and 45% of total phenol were extracted from antioxidant nutrients contained in fresh vinegar.

Therefore, it can be seen that it is effective to use the whole fresh vinegar powder rather than using the fresh vinegar extract when preparing the health supplement showing the antioxidant activity according to the present invention.

In addition, the antioxidant nutrients contained in the dietary supplements may be lost during the storage period, and the safety of the antioxidant nutrients contained in the fresh vinegar while drying for a long time by varying the storage temperature after drying powdered fresh vinegar.

3 is a graph showing the stability according to the storage temperature of the antioxidant component contained in the fresh vinegar powder prepared according to the present invention, Figure 3a is lutein (Lutein), Figure 3b is trans beta-carotene (trans β-carotene), Figure 3c shows a 9-cis beta-carotene (9-cis β-carotene), Figure 3d shows a graph for the total phenols (Total phenols). As shown in FIG. 3, most of the antioxidant nutrients in the fresh vinegar dry powder were stable even after long-term storage at room temperature except for beta-carotene. The beta-carotene was stable for 4-5 months when refrigerated fresh vinegar powder. Lutein was stable for 12 months, and after 12 months the decrease was significantly reduced.

Therefore, it can be seen that the antioxidant nutrients contained in the fresh vinegar powder according to the present invention are mostly stable at room temperature.

Experimental Example  2: Biomedical and Biochemical Characteristics of Subjects

A total of 126 subjects were recruited, 121 were screened in advance, and 10 qualified subjects (5; normal healthy, 5; metabolic syndrome patients) through a physical examination and various blood tests on a total of 40. ) Was selected.

Five healthy individuals selected to participate in the study showed normal liver and kidney function, normal serum protein metabolism and normal fat metabolism, no kidney stones, acute gastritis, hyperlipidemia, diabetes, pancreatic disease, and hormones. The body mass index (BMI) was less than 30. In addition, vitamins and carotenoid supplementation were not taken 6 weeks before the start of the study.

The eligibility of each of the five normal and metabolic syndrome patients involved in the study is shown in Table 1 below.

Eligibility Normal people
(n = 5,> 50yr) Metabolic syndrome patients
(n = 5,> 50yr) Fasting Blood Sugar <100 mg / dL ≥100 mg / dL Abdominal obesity BMI 18.5-30 and
W / H ratio ≤ 0.9 for M,
≤ 0.85 for F W / H ratio> 0.9 for M,
> 0.85 for F Blood pressure and triglyceride SBP <130 mm Hg and
DBP <85 mmHg and
TG <150 mg / dL SBP 130 mmHg or
DBP 85 mmHg or
TG 150 mg / dL Blood pressure or hemostatic drugs No Yes, no DM medication

Table 2 shows the high-density-cholesterol (HDL cholesterol), low-density-cholesterol (LDL cholesterol), blood glucose, infectious agents (CRP,) in the blood of normal healthy subjects (n = 5) and metabolic syndrome patients (n = 5) who participated in the study. IL6) and the like. Patients with metabolic syndrome had significantly lower concentrations of high-density cholesterol, higher triglycerides, and lower adiponectin than normal subjects.

Normal healthy person (n = 5) Metabolic syndrome (n = 5) Total cholesterol (mg / dL) 198.80 ± 5.34 199.20 ± 16.99 HDL cholesterol (mg / dL) 76.40 ± 4.59 41.80 ± 3.71 ^** LDL Cholesterol (mg / dL) 107.00 ± 3.42 117.60 ± 15.94 VLDL Cholesterol (mg / dL) 15.40 ± 2.20 39.80 ± 8.49 ^* Triglycerides (mg / dL) 79.40 ± 10.87 201.20 ± 42.59 ^* Blood sugar (mg / dL) 92.40 ± 3.14 97.80 ± 3.22 Hemoglobin A1C (%) 6.06 ± 0.07 6.23 ± 0.14 Adiponectin (μg / mL) 19.40 ± 6.79 5.78 ± 1.05 ⁺ IL6 (pg / mL) 1.63 ± 0.46 2.30 ± 0.60 CRP (mg / L) 1.90 ± 1.10 3.84 ± 2.07

Table 3 below shows the concentrations of antioxidant nutrients in blood of normal healthy subjects (n = 5) and metabolic syndrome patients (n = 5). In patients with metabolic syndrome, serum levels of cryptoxanthin and beta-carotene were significantly lower than those of normal subjects, but not significantly, but concentrations of lutein and alpha-tocopherol tended to be lower than those of normal subjects.

Antioxidant nutrients Normal healthy person (n = 5) Metabolic syndrome (n = 5) Water soluble antioxidants (mg / dL) Ascorbic acid 3.21 ± 1.23 2.80 ± 0.43 Yulic acid 4.68 ± 0.48 6.44 ± 0.48 Fat-soluble antioxidant nutrients (㎍ / dL) Lutein 0.72 ± 2.14 12.42 ± 3.81 Cryptoxanthin 8.17 ± 0.75 4.34 ± 1.31 α-carotene 10.96 ± 0.81 6.58 ± 1.84 beta -carotene 60.66 ± 15.40 19.54 ± 6.81 Trans-lycopene 27.20 ± 2.71 24.78 ± 6.46 Cis-lycopene 28.67 ± 3.06 20.29 ± 4.63 α-tocopherol 1688.6 ± 85.30 1367.6 ± 293.6 Retinol 55.78 ± 2.26 54.74 ± 5.76

Table 4 below shows the degree of DNA damage and DNA methylation of normal healthy subjects (n = 5) and metabolic syndrome patients (n = 5). At this time, oxidative DNA damage was analyzed by single cell gel electrophoresis, and DNA methylation was analyzed by liquid chromatography-mass spectrometry (LC-MS).

DNA of metabolic syndrome patients is found to be significantly damaged compared to normal healthy.

Oxidative DNA damage 7.67 ± 1.79 17.9 ± 3.64 Genetic DNA Methylation 4.56 ± 0.04 4.57 ± 0.10

Experimental Example  3: human body following intake of health supplement food containing fresh vinegar In the blood Quacithin  absorption Kinetic

30 minutes, 60 minutes, 120 minutes, 180 minutes, before and after ingestion of the dietary supplement of the Example containing 5 g of fresh vinegar powder to normal healthy persons (5 persons) and metabolic syndrome patients (5 persons) over 50 years old. Blood was collected at 240 minutes, 300 minutes, 360 minutes, 420 minutes, and 480 minutes to determine the amount of each quacithin. At this time, the amount of flavonoids (Free + phase II enzyme conjugated flavonoids) in the blood was analyzed by high performance liquid chromatography (HPLC-ECD).

Figure 4a is a graph showing the change in the content of the quasi-citin in the blood of normal healthy people after intake of the dietary supplement containing fresh vinegar powder according to the experiment, Figure 4b is the quasi-citin content in the blood of the patient with metabolic syndrome after intake of the dietary supplement Graph showing change. As shown in FIG. 4, when the dietary supplement containing the fresh vinegar powder was ingested, the amount of quacithin in the blood increased from 1 hour to 3 hours, 6 hours to 8 hours in normal healthy individuals, and metabolic. In the case of syndrome patients, the amount of quacithin in the blood increased after 30 minutes of ingestion, and the increase was maintained up to 8 hours after ingestion.

Experimental Example 4: Absorption Kinetics of Carotenoids in Human Blood with Intake of Fresh Supplements

30 minutes, 60 minutes, 120 minutes, 180 minutes, before and after ingestion of the dietary supplement of the Example containing 5 g of fresh vinegar powder to normal healthy persons (5 persons) and metabolic syndrome patients (5 persons) over 50 years old. Blood was collected at 240, 300, 360, 420 and 480 minutes to determine the amount of each carotenoid.

The fresh vinegar powder-containing dietary supplement ingested by the study subject contained about 2 mg of lutein and about 1 mg of beta-carotene, as shown in Table 5 below.

nutrient Content (㎍ / g) Μg / one dose (5g) Lutein 414.9 ± 1.14 2074.7 ± 5.7 α-carotene 24.5 ± 3.98 122.5 ± 19.9 trans β-carotene 216.2 ± 3.59 1081.2 ± 17.9 9 cis β-carotene 36.31 ± 1.53 181.5 ± 7.6

Measurement of carotenoids in the blood (lutein, zeaxanthin, beta-carotene, alpha-carotene, kryptoxanthin, lycopene) is carried out by extracting the fat-soluble components in the blood using the Folch method, and reverse-phase chromatography The oil soluble antioxidants were simultaneously measured using an HPLC system.

Figure 5a is a graph showing the beta-carotene absorption kinetic in the blood of the normal health person after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 5b is a normal health person after intake of the dietary supplement It is a graph showing the absorption kinetic of lutein.

As shown in FIG. 5, the blood concentration of beta-carotene was increased after ingestion of the dietary supplement of the normal healthy subject, but was not significant. Lutein blood concentration increased significantly from 30 min after ingestion, and the increased concentration was maintained for up to 8 hours.

Figure 6a is a graph showing the beta-carotene absorption kinetic in the blood of the metabolic syndrome patient after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 5b is a metabolic syndrome patient after intake of the dietary supplement It is a graph showing the absorption kinetic of lutein.

As shown in FIG. 6, in patients with metabolic syndrome, the blood concentration of beta-carotene was significantly increased from 5 hours after ingesting the dietary supplement of Example, and maintained significantly high concentration up to 8 hours. The blood concentration of lutein was increased from 6 hours after ingesting the dietary supplement of Example to maintain a high concentration up to 8 hours.

Therefore, it can be seen that both normal healthy people and patients with metabolic syndrome have an efficient absorption of carotenoids, which are antioxidant nutrients contained in the dietary supplements of Examples.

Experimental Example  5: Human body following intake of health supplement food containing fresh vinegar In the blood  Antioxidant function Kinetic

30 minutes, 60 minutes, 120 minutes, 180 minutes, before and after ingestion of the dietary supplement of the Example containing 5 g of fresh vinegar powder to normal healthy persons (5 persons) and metabolic syndrome patients (5 persons) over 50 years old. Blood was collected at 240, 300, 360, 420, and 480 minutes to determine the total antioxidant activity in these blood.

Total antioxidant performance in blood was measured by induction of oxidation with MeO-AMVN, and then the oxidative kinetics of BODIPY were measured using a fluorescent spectrophotometer.

Figure 7a is a graph showing the antioxidant function kinetics in the blood of normal healthy people after intake of dietary supplement containing fresh vinegar powder according to an embodiment of the present invention, Figure 7b is a blood of the patient of metabolic syndrome after the dietary supplement intake It is a graph showing the antioxidant function kinetics. As shown in FIG. 7, the total antioxidant activity in blood was increased in 1,3,6,7 hours after ingesting the dietary supplement of Example, and in the case of patients with metabolic syndrome, the dietary supplement of Example Increased in 30 minutes and 5 hours after ingestion.

As described above, it can be seen that the intake of fresh vinegar powder-containing dietary supplement according to the present invention increases the blood concentration and antioxidant function of the antioxidant nutrients in metabolic syndrome patients with high oxidative stress as well as normal people. The dietary supplement according to the present invention also reduces the oxidative stress of the elderly, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease and patients with diseases caused by oxidative stress such as dementia, obesity and chronic diseases, which are elevated oxidative stress. And antioxidant properties.

Claims (11)

Fresh vinegar powder 10-20 wt%, rice flour 10-20 wt%, caramel pigment 5-10 wt%, maion starch 25-30 wt%, fructose 10-15 wt%, glucose 10-15 wt%, maltodextrin 1 ~ Health supplement with antioxidant activity, including 5% by weight, sunflower seed oil 3-10% by weight and lecithin 0.05-1% by weight.
The dietary supplement with antioxidant activity of claim 1, wherein the fresh vinegar powder is prepared according to a vacuum freeze drying method.
The dietary supplement with antioxidant activity according to claim 1, wherein the size of the fresh vinegar powder is 50 to 250 mesh.
The dietary supplement with antioxidant activity of claim 1, comprising 0.5 to 30% by weight of fresh vinegar powder.
The dietary supplement with antioxidant activity of Claim 1 which further contains a foodstuff acceptable food supplement additive.
The dietary supplement of claim 1 having antioxidant activity in the form of a powder, granule, tablet, capsule, beverage or bread.
delete (S1) washing and cutting fresh vinegar;
(S2) freezing the cut fresh vinegar;
(S3) drying the frozen fresh vinegar; And
(S4) A method of producing a health supplement food having the antioxidant activity of claim 1 comprising the step of crushing the dried fresh vinegar.
The method of claim 8, wherein (S2) step is carried out for 12 to 36 hours at -80 ° C ~ -40 ° C.
The method of claim 8, wherein (S3) step is carried out for 35 to 38 hours at 45 ℃ to 48 ℃ manufacturing method of health supplements having antioxidant activity.
The method of claim 8, wherein the step (S4) is 60% to 65% of the method of producing a dietary supplement with antioxidant activity that is carried out in a condition where the humidity is controlled.

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