KR101192228B1 - Patch - Google Patents

Abstract

A patch comprising a support sheet having a urethane resin layer and a water-soluble solid, wherein the urethane resin layer contains an aromatic isocyanate, a polyether polyol, and a polyurethane resin obtained by reacting a chain extender as necessary. .

According to this invention, the support sheet can provide the patch which has the outstanding resistance to the component in a water-soluble solid, and has the outstanding storage stability.

Urethane, Supports, Sheets, Patches, Isocyanates, Polyurethanes, Water-Soluble Solids

Description

Patches {PATCH}

The present invention provides a support sheet having a urethane resin layer and a patch having a water-soluble solid, wherein the support sheet having a urethane resin layer has excellent resistance to components in the water-containing solid even after long-term storage. It has a patch which is inconspicuous even if a patch is attached.

Conventionally, the patch which extended the water-based adhesive agent to the support body, such as a nonwoven fabric, is used, but after affixing it on skin, since water evaporates, the water-based adhesive hardens | cures and the skin migration property of an active ingredient falls, The fall of adhesive force was a problem. Moreover, since these patchs have thickness, they have a problem of being uncomfortable and noticeable when applied to the skin.

Therefore, a method of using a support of a sheet-like body in which a polymer film and a porous sheet are integrated is proposed (see Patent Document 1: Japanese Patent No. 3044352), and furthermore, knitting is performed in which the thickness and basis weight of the fibers are in a specific range. The technique of making a patch transparent is proposed by laminating | stacking a water-containing adhesive on the said fiber layer of the support body which laminated | stacked the cloth and the transparent film (refer patent document 2: Unexamined-Japanese-Patent No. 2003-169823). Moreover, the patch using the polyurethane film is proposed (patent document 3: Unexamined-Japanese-Patent No. 2136023).

However, like patent document 3, when only a polyurethane film is used for a support body, a water-based adhesive is not anchored. In addition, as described in Patent Literatures 1 and 2, even when integrated with the porous sheet and securing the anchoring property of the water-based adhesive, when using a highly elastic polyurethane that is easy to follow the movement of the skin, Since an adhesive contains water, there existed a problem that a support body deform | transforms or deteriorates with components, such as an active ingredient, a dissolving agent, and surfactant in a water-based adhesive.

By the above, even after the support sheet stored for a long time, the patch which has tolerance to components, such as an active ingredient, a dissolving agent, surfactant, etc. in a water-based adhesive, and is inconspicuous even when affixing it was anticipated.

[Patent Document 1] Japanese Patent No. 3044352

[Patent Document 2] Japanese Unexamined Patent Publication No. 2003-169823

[Patent Document 3] Japanese Patent No. 2136023

This invention is made | formed in view of the said situation, and it is inconspicuous even when affixing, a support sheet has the outstanding tolerance with respect to the component in a water-soluble solid, and it does not have wrinkles and stickiness even after long-term storage, and weakens a strength. It is an object to provide a patch which is difficult and inconspicuous even when affixed.

MEANS TO SOLVE THE PROBLEM In order to achieve the said objective, in order to achieve the said objective, as a result of earnestly examining in urethane structure and making it into the support sheet containing the urethane resin layer obtained by making aromatic isocyanate and polyether polyol react, a support sheet is a component in a water-containing solid The inventors have found that a patch having excellent resistance to and which is inconspicuous even when applied can be obtained, thereby achieving the present invention.

Therefore,

[1] A support sheet having a urethane resin layer and a patch having a water-soluble solid, wherein the urethane resin layer contains an aromatic isocyanate and a polyether polyol and a polyurethane resin obtained by reacting a chain extender as necessary. Patch,

[2] The patch according to [1], wherein the aromatic isocyanate is 4,4'-diphenylmethane diisocyanate or a derivative thereof.

[3] The patch according to [1] or [2], wherein the polyether polyol is polytetramethylene ether glycol or a derivative thereof.

[4] the urethane resin layer contains a resin mixture of aromatic isocyanate, polyether polyol, and 100 parts by mass of a polyurethane resin obtained by reacting a chain extender, if necessary, with 0.1 to 10 parts by mass of a fluorinated urethane resin. The patch according to any one of [1] to [3],

[5] The patch according to any one of [1] to [4], wherein an aqueous solid is inverted on the fiber sheet layer side of the support sheet formed by laminating a urethane resin layer and a fiber sheet layer;

[6] The patch according to [5], wherein the fiber sheet is a knitted fabric;

[7] The moisture permeability of the support sheet is 200 to 4000 g / m 2/24 hr in the condition (B) test of JIS general test method "Water vapor transmission test method (cup method) of moisture proof packaging material", characterized in that [1] to The patch according to any one of [6],

[8] The patch according to any one of [1] to [7], wherein the water-containing solid contains polyacrylic acid and / or polyacrylate.

(Best Mode for Carrying Out the Invention)

The patch of the present invention is a support sheet having a urethane resin layer and a patch having a water-soluble solid, wherein the urethane resin layer is obtained by reacting an aromatic isocyanate with a polyether polyol and a chain extender as necessary. It contains a urethane resin.

As the polyurethane resin, one obtained by reacting an aromatic isocyanate, a polyether polyol, and a chain extender as necessary is used. As this urethane resin, you may use it, mixing or copolymerizing 2 or more types of urethane resin arbitrarily.

Examples of the aromatic isocyanates include 4,4'-diphenylmethane diisocyanate, tolylene diisocyanate, xylene diisocyanate, parachlorphenyl isocyanate, orthochlorphenyl isocyanate, 3,4-dichlorphenyl isocyanate, and 2,5-dichlorophenyl isocyanate. , Polymethylene polyphenyl isocyanate, triphenylmethane triisocyanate, tris (4-phenylisocyanatethiophosphate), N, N '(4,4'-dimethyl-3,3'-diphenyl diisocyanate) uredione, 4, 4 ', 4 "-trimethyl-3,3", 3 "-triisocyanate-2,4,6-triphenylcyanate, isopropenyldimethylbenzyl isocyanate and derivatives thereof, and the like. Preference is given to 4,4'-diphenylmethane diisocyanate and derivatives thereof.

As a polyether polyol used for the polyurethane resin of this invention, 1 type, 2 or more types of random and / or block addition product of ethylene oxide, a propylene oxide, butylene oxide, tetrahydrofuran are mentioned. In particular, the ring-opening polymerization product and adduct of 2 or more types of alkylene oxide (C2-C4) containing tetrahydrofuran alone or it is preferable. A polyether polyol can be used individually by 1 type or in combination of 2 or more types. As polyether polyol, polytetramethylene ether glycol and its derivatives are preferable.

Although a chain extender is not specifically limited, The compound containing two or more active hydrogens, such as low molecular glycol, such as ethylene glycol, low molecular diamine, and low molecular amino alcohol, can be used. These can be used individually by 1 type or in combination of 2 or more types.

As a polyurethane resin used for this invention, the resin mixture of the polyurethane resin (henceforth aromatic isocyanate polyether polyol resin) obtained by making the said aromatic isocyanate, polyether polyol, and chain extender react as needed is a fluorinated urethane resin. It is preferable to use. As a fluorine urethane resin, the urethane resin introduce | transduced at least 1 sort (s) from a fluorine atom, a perfluoroalkyl group, and a perfluoroalkylene group is mentioned. Urethane fluoride resin can be used individually by 1 type or in combination of 2 or more types.

As for the mixture ratio of aromatic isocyanate polyether polyol resin and a fluorinated urethane resin, 0.1-10 mass parts of urethane fluoride resins are preferable with respect to 100 mass parts of aromatic isocyanate polyether polyol resins, More preferably, it is 0.5-1.0 mass part. . When the ratio of the urethane fluoride resin is small, the effect of resistance to components in the water-containing solid may not be exhibited in some cases. Moreover, when there are too many, adhesiveness with a water-containing solid may fall.

Although preparation of a urethane resin layer is not specifically limited, For example, it can obtain by the following method.

15-30 mass% of solvents (DMF: MEK = 1) for the resin mixture of aromatic isocyanate polyether polyol resin alone, aromatic isocyanate polyether polyol resin and urethane fluoride resin, or these and other urethane resins It is a solution of (10). After apply | coating this solution on a release paper with a comma coater etc., it processes for 1 to 5 minutes by dry heat of 80-150 degreeC.

5-30 micrometers is preferable and, as for the thickness of a urethane resin layer, More preferably, it is 10-20 micrometers. The viscosity of the 20 mass% solution (solvent DMF) of polyurethane resin was measured by rotor No. 7 and 20 rotation using the BH viscometer.

Although the support sheet of this invention has a support sheet which has a urethane resin layer, the support sheet formed by laminating | stacking a urethane resin layer and a fiber sheet layer is preferable at the point of projecting a water-soluble solid. In this case, it is preferable to extend the water-soluble solid on the fiber sheet layer side.

As a fiber used for a fiber sheet layer, at least 1 sort (s) of fiber chosen from a knitted fabric, a woven fabric, and a nonwoven fabric can be used. Among these, a knitted fabric is preferable because it has elasticity, is excellent in stretch back properties after stretching, and smoothly follows the stretch of the skin when affixed to the skin.

Examples of the fibers include synthetic fibers such as polyester fibers, polyamide fibers, polyacrylic fibers, polyethylene fibers, polypropylene fibers, polyvinyl chloride fibers, polyvinyl alcohol fibers and polyurethane fibers, and semisynthetic fibers such as acetate, rayon and cupra. Natural fibers, such as cotton, hemp and wool, may be used alone or in combination of two or more thereof. Among these, polyester fiber, polypropylene fiber, and polyethylene fiber are preferable.

Although it does not specifically limit as a knitting method of the knitted fabric of this invention, A warp knitted fabric (Tricot, Raschel) or a upper knitted fabric (horizontal knitted fabric, circular knitted fabric) is employ | adopted. Although it does not specifically limit as a knitting structure, For example, in a warp knitting, a half piece, an inverse half piece, an atlas piece, a double atlas piece, a queen's cord piece, a upper piece, a flat piece, a rubber piece, and a pearl piece are mentioned.

The support sheet formed by laminating a urethane resin layer and a fiber sheet layer can be obtained by laminating and integrating these two layers. Although it does not specifically limit as a lamination | stacking method, An adhesive method, a heat-compression bonding method, a laminator method, an extrusion laminator method, etc. are mentioned. The adhesive part may be any part or the whole surface of the fiber sheet layer. As an adhesive agent when integrated by the adhesive method, a thermosetting adhesive agent, a thermoplastic adhesive agent, a rubber adhesive agent, etc. are mentioned. Specifically, examples of the thermosetting adhesive include amino resins, phenol resins, resonol resins, xylene resins, epoxy resins, unsaturated polyesters, and the like. As thermoplastic adhesives, polyisocyanates, polyurethanes, polyvinyl acetates, polyacrylic acid esters, and polyvinyl resins. Acetal, polyvinyl chloride, polyvinylidene chloride, polyvinyl ether, polyethylene vinyl acetate, polyamide, polyester and the like include natural rubber, styrene butadiene rubber, acrylonitrile butadiene rubber and the like.

As for the water vapor transmission rate of the support sheet of this invention, 200-4000g / m <2> / 24hr is preferable, More preferably, it is 1000-3000g / m <2> / 24hr or more, More preferably, it is 1500-1500g / m <2> / 24hr. When moisture permeability is less than 200, moisture may fill up at the time of sticking. On the other hand, when it exceeds 4000 g / m <2> / 24hr, a solid hardens | cures by evaporation of water, and adhesiveness falls, or water absorption of an active ingredient falls. Here, the said water vapor transmission rate can be confirmed by measuring by the JIS general test method "moisture-permeability test method (cup method) of a moisture proof packaging material" condition (B).

Although the elongation recovery rate of the support sheet of this invention is not restrict | limited, The following 50% elongation recovery rate is 75% or more, Preferably it is 85% or more in both a longitudinal direction and a horizontal direction. When it is less than 75%, it may not follow the elasticity of skin smoothly at the time of sticking.

<50% elongation recovery rate>

Samples of 25 x 150 mm are taken in both vertical (flow direction at the time of inflation) and horizontal (orthogonal directions to the flow direction at the time of inflation), and using a tensile tester, a holding interval of 100 mm and a tensile speed of 200 mm / min. Stretch 50 mm and return until the stress becomes zero at the same speed. The initial length A (100 mm) of the sample and the length B of the sample after the tensile test are read from the chart paper, and calculated by the following equation.

50% Elongation Recovery Rate (%) = 100- (B-A) × 100 / (A × 0.5)

(However, in the above formula, A represents the initial length (100 mm) of the sample, B represents the length (mm) of the sample after the tensile test.)

The following 30% modulus of the support sheet of the present invention is not particularly limited, but is preferably 8.0 N / 25 mm or less, preferably 6.0 N / 25 mm or less, and more preferably 3.0 N / 25 mm or less. When it exceeds 8.0 N / 25 mm, it may not follow the elasticity of skin smoothly at the time of sticking.

<30% modulus>

Samples 25 × 150 mm in both longitudinal (flow direction at the time of inflation) and transverse (orthogonal directions to the flow direction at the time of inflation) are taken, and a tensile tester is used to hold a holding interval of 100 mm and a tensile speed of 200 mm / min. The stress at the time of 45 mm extension was measured.

As for the water-soluble solid used for the patch of this invention, the water-containing gel containing an adhesive high molecular compound and water is preferable. It is preferable that the adhesive high molecular compound is bridge | crosslinked by a crosslinking agent, radiation irradiation, etc. In particular, a hydrous gel obtained by adding a crosslinking agent such as a polyvalent metal salt to a matrix containing polyacrylic acid and / or polyacrylate is gelated. Moreover, when other high molecular compound is mix | blended with a matrix base material, since the adhesiveness (functional gel) with a favorable usability is obtained, it is more preferable.

As said polyacrylic acid, any can be used, Although there is no restriction | limiting in particular in the molecular weight and shapes, such as a linear and branched chain, It is preferable to use the weight average molecular weight 1-10 million, Especially the weight average molecular weight is 1-500,000. When two or more types of polyacrylic acid or its salts having less than 50 to 2 million and an average molecular weight of 2 to 7 million are combined, it is suitable because the usability is improved. In addition to the polymer obtained by polymerizing ordinary acrylic acid, a part of crosslinked acrylic acid polymers such as carboxyvinyl polymer, for example, Akpek (trade name: Sumitomo Seika Co., Ltd.) can be suitably used.

Moreover, as polyacrylate, the monovalent metal salt of polyacrylic acid, such as sodium polyacrylate and potassium polyacrylate, the amine salt of polyacrylic acid, such as polyacrylate monoethanolamine, the polyacrylate diethanolamine, and the polyacrylate triethanolamine, and the ammonium salt of polyacrylic acid And 1 type, or 2 or more types, such as partial neutralization, can be used suitably.

It is preferable that the compounding quantity of polyacrylic acid and / or polyacrylic acid salt shall be 1-20 mass%, especially 3-15 mass% of the whole hydrous solid. When the amount is too small, the seedling force may be insufficient. When the amount is too large, the viscosity may increase, causing problems in workability at the time of manufacture, and feeling pain when peeling off the patch.

Examples of the crosslinking agent include polyvalent metal ion crosslinking agents and organic cationic crosslinking agents. As a polyvalent metal ion crosslinking agent, it is a compound which releases polyvalent metal ion in aqueous solution, The kind in particular is not restrict | limited, as long as it can metal-crosslink the water-soluble high molecular compound which crosslinks with a metal. For example, magnesium compounds, calcium compounds, zinc compounds, cadmium compounds, aluminum compounds, titanium compounds, tin compounds, iron compounds, chromium compounds, manganese compounds, cobalt compounds, nickel compounds and the like can be given. The patch of the present invention is applied to the skin, and in consideration of safety on the skin, it is preferable to use an aluminum compound, a magnesium compound, a calcium compound or the like.

In this case, any of an aluminum compound, a magnesium compound and a calcium compound can be suitably used. For example, alum, such as potassium alum, alumina, iron alum, aluminum hydroxide, aluminum sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum silicate, aluminum metasilicate, calcium hydroxide, calcium carbonate, Calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate, magnesium hydroxide, magnesium carbonate, magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, magnesium aluminate hydroxide, magnesium aluminate silicate, magnesium aluminate silicate, 1 type, or 2 or more types chosen from water-soluble compounds, such as a synthetic hydrotalcite, a double salt containing these metals, and a poorly water-soluble compound, can be used combining them suitably. An antacid containing aluminum and magnesium can also be blended as a polyvalent metal salt. Among these, magnesium aluminate silicate, magnesium metasilicate aluminate, aluminum glycinate, synthetic hydrotalcite and alum are preferable.

The organic cationic crosslinking agent is not particularly limited as long as it has at least two cationic groups such as N ⁺ and S ^{+ in the} molecule, but a cationic group is preferably a N ⁺ group. More preferably, the cation group is a trimethylammonium group or a polydimethyldiarylammonium group. In addition, the main chain is preferably a polysaccharide-based high molecular compound. For example, a vinyl cationic polymer and a cationized polysaccharide are mentioned, Specifically, a poly-4 (2) -vinylpyridine, an ionene polymer (made by Aldrich), N-trialkylaminomethyl polystyrene, amino acetalization Polyvinyl alcohol, poei-4 (5) -vinylimidazole, linear polyethyleneimine, polyethyleneimine, polydialkyldiarylammonium salt, dialkyldiarylammonium salt-SO ₂ copolymer, cationic dextran, cationic starch Cationic celluloses such as cationic polyvinylpyrrolidone (cationized PVP), trimethyl ammonium cationized cellulose, polydimethyldiarylammonium cationized cellulose, dimethyllaurylammonium cationized cellulose, cationic PVA, Polydimethyldiarylammonium salt-acryl amide copolymer, dimethyldiarylammonium salt-acryl amide copolymer, cationized guar gum, chitosan, gelatin or these salts, for example For example, fluoride, chloride, bromide, iodide, etc. are mentioned. These can be used individually by 1 type or in combination of 2 or more types. Among these, cationic starch, cationic PVP, cationic celluloses, and cationic guar gums are preferable.

The molecular weight of an organic cationic crosslinking agent is 1,000-100,000,000 normally. From the point of obtaining good elasticity and the shape retention for producing the gel well, 10,000-10,000,000 is preferable, More preferably, it is 50,000-10,000,000.

Although the compounding quantity of a crosslinking agent changes with various kinds, it does not restrict | limit especially, It is preferable to set it as 0.001-40 mass%, especially 0.05-20 mass% of the whole hydrous solid. When there is too little compounding quantity, cohesion may be insufficient, and when too large, a viscosity may become high and a problem may arise in adhesiveness or manufacturability.

In addition to a crosslinking agent, it is preferable to mix | blend a hardening regulator. As a hardening regulator, citric acid, malic acid, tartaric acid, an edetic acid salt etc. are mentioned, for example. These can be used individually by 1 type or in combination of 2 or more types. Although the compounding quantity of a hardening regulator can be selected suitably, Usually, it is 0.001-10 mass% of the whole hydrous solid, Preferably it is 0.005-2 mass%.

In addition, when mix | blending another high molecular compound, the kind in particular is not restrict | limited, The thing conventionally used can be used. For example, gelatin, agar, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, carboxymethyl cellulose, carboxymethyl cellulose sodium, hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, sodium alginate, xanthan gum, Arabia Gum, tragant gum, karaya gum, maleic anhydride copolymer, propylene glycol, carboxymethyl starch sodium, carrageenan and the like. These may be used alone or in combination of two or more thereof, but in the case of the present invention, in particular, carboxymethyl cellulose sodium is mixed with the polyacrylic acid and / or polyacrylic acid salt, and other polymer compounds may be added as necessary. It is preferable to mix and use. In addition, the compounding quantity of these other high molecular compounds can be suitably selected in the range which does not impair transparency of the water-soluble solid of this invention.

The water-soluble solid of the present invention may be optionally blended with other components as necessary. For example, an active ingredient, a warming imparting ingredient, an emulsifier, a moisturizing ingredient (polyalcohol), a cooling agent, an inorganic powder, a preservative, a fragrance, a pigment, etc. can be mix | blended individually by 1 type or in combination of 2 or more types as appropriate. .

More specifically, examples of the active ingredient include salicylic acid and its salts, salicylic acid derivatives such as aspirin, acetaminophen, aminopyrin, antipyrin, oxyphenbutazone, sulfirin, indomethacin, diclofenac sodium, ibuprofen, sryndak, naproxen and keto. Propene, etofenamate, salicylic amide, triethanolamine salicylate, flufenamic acid, its salts and derivatives thereof, mefenfenic acid and its salts and derivatives thereof, colchicine, bufexamak, ibufenac, roxofene , Penbufen, diflunisal, alclofenac, phenylbutazone, felbinac, mefenamic acid, its salts and derivatives thereof, fenofene, bendazac, pyroxicam, flurbiprofen, zaltoprofen, Etodolak etc. are mentioned.

Examples of the warmth imparting component include capsaicin analogues such as capsaicinoid, capsaicin, dihydroxycapsaicin, and capxanthine, capsiccoside, capsicum extract, capsicum tink, capsicum derivatives such as capsicum powder, nicotinic acid benzyl and nicotinic acid β-part. It is methoxyethyl, N-acylvanylamide, nonyl acid vanylamide, and vanylyl alcohol alkyl ether represented by following General formula (1), These can be used individually by 1 type or in combination of 2 or more types as appropriate.

(1)

(One)

(In formula, R represents a C1-C6 alkyl group.)

As for the compounding quantity (the total compounding quantity in the case of 2 or more types of combined use) of the said warmth provision substance with respect to the water-containing solid of this invention, 0.0001-5 mass% is preferable with respect to the whole water-based solid, More preferably, it is 0.001--3 mass %, More preferably, it is 0.005-1 mass%. When the compounding quantity of the said warmth provision substance is too small, sufficient warmth may not be provided, and when too large, skin irritation may arise.

Examples of the emulsifier include polyglycerol fatty acid esters such as diglycerin monostearate, polyoxyethylene glycerin fatty acid esters such as polyoxyethylene (POE) (10) glyceryl monooleate, polyoxyethylene fatty acid esters, and POE. (25) polyoxyethylene alkyl ethers such as lauryl ether, polyoxyalkylene alkyl ethers such as polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl ether sulfuric acid (ester) salts, fatty acid soaps, sorbitan fatty acid esters, Glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hardened castor oil, alkyl sulfate, N-acylmethyltaurine salt, alkyl ammonium salt, beta acetate, propylene glycol fatty acid ester, vitamin derivative, glycyrrhizin acid, glycyrrhetitin Acids, derivatives thereof, and the like. Specifically, sorbitan monooleate, glyceryl monooleate, decaglyceryl monooleate, diglyceryl dioleate, hexaglyceryl monolaurate, propylene glycol monostearate, POE (20) sorbitan monooleate , POE (60) sorbitol tetraoleate, POE (40) monostearate, POE (10) oleyl ether, POE (10) nonylphenyl ether, POE (50) hardened castor oil, POE (5) oleic acid amide, Sodium lauryl sulfate, sodium POE alkyl ether sulfate, sodium POE alkyl ether acetate, triPOE (10) alkyl ether phosphoric acid, stearyltrimethylammonium chloride, benzalkonium chloride, lauryldimethylamino acetic acid betaine, egg yolk, lecithin, imidazoli Nium betaine, diethyl sebacate, and the like.

As said moisturizing component (polyhydric alcohol), glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, 1,3-propanediol, 1,3-butanediol, 1,4-butanediol, maltitol, xylitol These etc. are mentioned, These can be used individually by 1 type or in combination of 2 or more types.

Examples of the coolant include menthol derivatives such as camphor, thymol, menthol, N-ethyl-p-mentan-carboxyamide, p-mentan-3,8-diol, 1-isofulegol, and 1-mentylglyceryl ether. These can be used individually by 1 type or in combination of 2 or more types as appropriate.

As said preservative, methyl paraben, propyl paraben, thymol, etc. are mentioned, These can be used individually by 1 type or in combination of 2 or more types.

As a fragrance, for example, fennel oil, castor oil, peppermint oil, peppermint white oil, meet balm, cinnamon oil, cloves oil, thyme oil, turpentine oil, henopodidi oil, breeze oil, eucalyptus oil, lavender oil, lemon oil, orange oil, and petroleum oil And essential oils such as bergamot oil, rose oil, citronella oil, lemongrass oil, camphor oil and geranium oil. Moreover, as a plant extract, for example, aloe, anise, angelica, benzoin, immortel, chamomile, chamomile, garlic, caldermon, galbanum, caraway, carrot seed, guai axwood, grapefruits, cypress, Sandalwood, cedarwood, juniper, star anise, sage, geranium, celery, thyme, tarragon, terebin, frankincense, violet, pine, parsley, birch, patchouli, rose, hyssop, fennel, black pepper, linden tree, myrrh, Yarrow, Lemon, Lemongrass, Rosemary, Laurel, Japanese Poplar, Maple Grass, Cornflower, Almond, Thistle, Arnica, Variety Cypress, Fennel, Calendula, Erica, Moth, Freshly, Natural Flower, Supervision, Chicory , Umbrella, Marigold, Celandine, Watercress, Genka, Gentiana, Sari Lanbo, Shikazen-shi, Birch, Grass Fern, Namgasae, Camphor, Periwinkle, Orthodox, Plum, Pear, San cherry tree, Jujube, Taxa , Dandelion, jimmy, chervil, spirits, astronomical dong, Sweets, brier, wild carrot, woochocho, peppermint, ash, mauve herb, baby swimming, ghostling, borage, mugwort, marjoram, melissa, keg, peach, mistletoe, eucalyptus, oyster, lavender, forsythia, Extracts from mustard radish and the like, but among them, in particular, chamomile, sage, parsley, rosemary, Japanese poplar, maple leaf, cornflower, anise, laurel, angelica, fennel, peppermint (peppermint, lemon balm) Extracts from lavender, thyme, and the like are suitable, and specific components of such extracts include, for example, monoterpene hydrocarbons, cineols, borneols, camphor (camphor), linanol, verbenol, flavonoids, choline, Amino acids, tannins, vegetable acids, fatty acids, clear glycosides, salicylic acid derivatives, sarbins, condensed tannins, phenolic acids, carnosine acids, triterpene acids, tuzones, sarbenes, pinene, apiol, apiolin, myristicine, Coumarin, camazurene, farnesene, bisabolol, geraniol, eugenol, terpene, ferrandin, anetol, menthol, mentone, limonene, citral, citronellal, eugenol acetate and the like. .

As a pigment | dye, the kind is not specifically limited, The pigment | dye described in a legal coloring handbook can be mix | blended.

Moreover, although the water content of the water-containing solid of this invention is not specifically limited, The water content per 100 mass parts of final compositions is 30-98 mass parts, More preferably, 40-95 mass parts is preferable. If the moisture content is too low, the anchoring property of the support sheet and the water-soluble solid may be worse. If the water content is too high, the physical properties of the adhesive gel may not be obtained. The pH of the water-soluble solid is preferably in the range of pH 3.5 to 6.0, and more preferably in the range of pH 4.0 to 5.5, from the viewpoints of stability of the drug to be blended and skin irritation.

The patch of this invention extends the said water-soluble solid to the said support sheet, and when using the support sheet which laminated | stacked a urethane resin layer and a fiber sheet layer, it is what extends a water-soluble solid to a fiber sheet layer side. good. Although the amount of the water-containing solid to extend is not specifically limited, Usually, 100-20,000 (g / m <2>), Preferably 200-1,500 (g / m <2>) is preferable. If the amount of leading edges is too large, it may be difficult to secure transparency (L value).

Among the components in the above-mentioned water-containing solid, the support sheet having the urethane resin layer of the present invention has particularly excellent resistance, and examples thereof include acidic drugs and oily components. Specifically, salicylic acid, salts thereof, indomethacin, Camphor, 1-menthol, and the like.

The manufacturing method of the patch of this invention is not specifically limited, For example, the composition component of the said water-soluble solid is spread evenly by a well-known method, and a water-soluble solid is prepared, and this water-soluble solid is knit side of the said support sheet. It can be uniformly extended, and can cover a water-soluble solid surface (solid surface) with a plastic film, cut | disconnect to moderate size, and can be made into a patch.

The thickness of the patch of this invention is 2 mm or less preferable, More preferably, it is 1.5 mm or less. Moreover, as for transparency (L value), it is preferable that L value obtained by the method described below becomes 15 or more.

<Measuring method of transparency (L value)>

It measured by the transmission method at 25 degreeC using the color difference meter (Nihon Denshoku Co., Ltd. Z-II), the (L, a, b) value was calculated | required, and transparency was evaluated with L value. As a standard for measurement, a standard white plate having a characteristic value of (L, a, b) = (94.59, 92.57, 111.43) is used.

(Example)

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, in the following example, when there is no specification in particular, "%" of a composition shows the mass%, and a ratio shows the mass ratio.

Preparation Example 1 of Urethane Resin Layer

Only aromatic isocyanate polyether polyol resin

A 25% solution (solvent: DMF: MEK = 1: 10) of the polyurethane resin obtained by reacting the isocyanates and polyols described in Examples 1, 3, 5 and Comparative Examples 1 and 2 in Table 1 with a comma coater was released. After apply | coating on it, it processed for 1 minute by dry heat of 100-140 degreeC, and the film-form urethane resin layer of 15 micrometers of film thicknesses was obtained.

Preparation Example 2 of Urethane Resin Layer

Aromatic isocyanate polyether polyol resin and fluorinated urethane resin

100 mass parts of polyurethane resin obtained by reacting the isocyanate and polyol of Examples 2, 4, 6, and Comparative Example 3 of Table 1, and a fluorinated polyurethane resin (made by Dainippon Ingiga Chemical Co., Ltd., brand name: SD -27) A 25% solution (solvent: DMF: MEK = 1:10) mixed with 0.5 parts by mass was applied onto a release paper by a comma coater, and then treated with dry heat at 100 to 140 ° C. for 1 minute to obtain a film thickness of 15 μm. The film-form urethane resin layer was obtained.

[Fiber Sheet Preparation Example 1: Flat]

After the polyester multifilament of 33 decitex was used and knitted into a double stitch structure by a circular knitting machine, refinement / set was performed to obtain a polyester knit of the desired knitting nose (well x cos).

[Fiber sheet preparation example 2: Atlas edition]

After the 33 decitex polyester multifilament was used and knitted into a 4-course atlas structure by a tricot knitting machine, it was refined / set to obtain a polyester knit of the desired knitting nose (well x cos).

[Support Sheet Preparation: Laminating Method]

The urethane resin layer and the polyester knit were laminated using the polyurethane-type reactive hot melt adhesive (manufactured by Dainippon Ingiga Chemical Co., Ltd., product name: NH-123) to obtain a support portion. The water vapor transmission rate, 50% elongation recovery and 30% modulus of the obtained support sheet were measured.

[Preparation of Water-Soluble Solid]

0.4 parts by mass of indomethacin in an emulsifier (2.0 parts by mass of sorbitan monooleate) and water were added to the mixture to prepare a common patch using a Henschel mixer, and stirring conditions. It is gradually added to the stirring vessel with stirring, and the stirring is continued, and a water-soluble polymer compound (1.5 mass parts of sodium polyacrylate, 6.0 mass parts of polyacrylic acid, 1.0 mass part of carboxyvinyl polymer, 4.0 mass parts of carboxymethylcellulose sodium) is added, In addition, a refreshing agent (0.5 parts by mass of 1-menthol) was added in sequence, and finally, a curing agent (0.2 parts by mass of synthetic hydrotalcite) was added and opened evenly until the whole became uniform. In addition, the sum total of a final composition is 100 mass parts.

[Examples 1-6, Comparative Examples 1-3]

The water-soluble solid obtained by the above method was directly stretched onto the fiber sheet of the support sheet so as to be 9.6 g per sheet (8 × 12 cm), and the water-based solid surface was covered with a polypropylene film, and the cut (8 × 12 cm) to obtain a patch. The obtained patch was made into 5 envelopes, and it preserve | saved for 6 months on 40 degreeC-75% RH conditions. (Wrinkling, stickiness, strength) of the support sheet after storage was evaluated by sensory evaluation. The results are shown in Table 1.

In addition, the measurement method of the viscosity of the polyurethane resin in a table | surface, the water vapor transmission rate of a support body, 50% elongation recovery rate, and 30% modulus is based on the method of the said description. The modulus of polyurethane resin produced the urethane resin layer of a film thickness of 30 micrometers, and cut it into 5x25 mm as a sample. Using a tensile tester, the holding | maintenance space | interval was made into 20 mm, and the stress at the time of extending | stretching by 300 mm / min of tensile velocity was measured.

The rough name in a table | surface is shown below.

MDI: 4,4'-diphenylmethane diisocyanate

HMDI: 4,4'-dicyclohexyl methane diisocyanate

      (Aliphatic isocyanates)

PTMG: Polytetramethylene ether glycol

PPG: Polypropylene Glycol

EG-AA: Ethylene glycol-adipic acid addition product (polyester type polyol)

EG: ethylene glycol

According to the present invention, the support sheet having a urethane resin layer and the patch having a water-soluble solid, the support sheet has excellent resistance to the components in the water-containing solid, and even after long-term storage, wrinkles and tackiness It is hard to weaken strength, and can provide the patch which is inconspicuous even if affixing.

Claims (9)

A patch comprising a support sheet having a urethane resin layer and a water-soluble solid, wherein the urethane resin layer is obtained by reacting 4,4'-diphenylmethane diisocyanate as an aromatic isocyanate with a polyether polyol. A polyurethane adhesive containing a polyurethane resin. As a patch provided with the support sheet which has a urethane resin layer, and a water-soluble solid, the said urethane resin layer makes 4,4'- diphenylmethane diisocyanate as aromatic isocyanate react with a polyether polyol, and a chain extender. It contains the polyurethane resin obtained, The patch characterized by the above-mentioned. delete The patch according to claim 1 or 2, wherein the polyether polyol is polytetramethylene ether glycol or a derivative thereof. The urethane resin layer is composed of 100 parts by mass of a polyurethane resin obtained by reacting an aromatic isocyanate with a polyether polyol and a chain extender as necessary, and 0.1 to 10 parts by mass of a fluorinated urethane resin. A patch comprising a resin mixture. The patch according to claim 1 or 2, wherein a water-soluble solid is spread on the fiber sheet layer side of the support sheet formed by laminating a urethane resin layer and a fiber sheet layer. The patch according to claim 6, wherein the fiber sheet is a knitted fabric. The water vapor transmission rate of the support sheet is 200-4000 g / m <2> / 24hr in the condition B test of JIS general test method "The moisture permeability test method of the moisture proof packaging material (cup method)." Patch to do. The patch according to claim 1 or 2, wherein the water-containing solid contains polyacrylic acid and / or polyacrylic acid salt.