KR101180446B1 - The method of preparing a suture - Google Patents

Abstract

The present invention relates to the manufacture of herbal herbal medicines produced using biodegradable polymers. More specifically, yarns produced by spinning with biodegradable polymer polypidioxanone (hereinafter referred to as PDO) from USP 3-0 to 9-0 are twisted into two, three or four strands or It is prepared by twisting five strands, or by applying a scratch or embossing effect on the surface to improve the production of biodegradable acupuncture needles for herbal medicine.

Description

Herbal chamber manufacturing method {The method of preparing a suture}

The present invention relates to a method for producing a herbal medicine chamber using a biodegradable polymer.

More specifically, two or more herbal medicine needles are twisted at once to penetrate into the human body to increase the more acupuncture stimulation effect, to provide a method for producing a herbal medicine needles.

Pharmacopuncture (藥 鍼) is a herbal treatment that is injected through acupuncture and drug action by injecting drugs into acupuncture points. Pharmacopuncture is also known as immune acupuncture, water acupuncture, water acupuncture, herbal acupuncture, and blood injection. Immunology (免疫 醫學) as one of the ingredients extracted from the herbal medicine to refer to the important acupuncture points (經穴). Acupuncture is a surgical therapy that stimulates the human body from the outside, and drug therapy is a medical therapy that internally stimulates the internal organs. By doing both of these at the same time to improve the treatment effect.

Namsangcheon in 1956 to identify meridians and strengthen immunity with acupuncture.In 1963, herbal medicines such as Sanjoin, Astragalus, Ginseng, and Antler were injected into the meridians using syringes to investigate the effects of meridians. It started at the beginning.

Acupuncture points are effective only by acupuncture stimulation, but they can be injected with certain drugs to achieve greater therapeutic effects. It is being researched and developed in various countries where oriental medical treatments such as Korea, China, and Japan are prevalent. In Korea, the Korean Academy of Oriental Medical Acupuncture and Moxibustion has been actively organized and researched on herbal acupuncture on August 26, 1990.

Typically, acupuncture includes acute inflammatory diseases, chronic wasting diseases, various neuralgia, arthralgia, low back pain, musculoskeletal disorders such as fifty shoulders, various respiratory disorders, gastroenteritis such as gastroenteritis, neuropsychiatric disorders such as urinary disorders, neurodebilitating chronic headaches, It is used to treat various dermatological diseases, high blood pressure and tumors.

For such treatment, recently, biodegradable surgical sutures are injected to give continuous stimulation to acupuncture points to give continuous stimulation during biodegradation to increase the treatment.

However, the disadvantage of the product used in this treatment is that since the monofilament of a simple shape having a smooth surface is used, the stimulation for menstrual blood is relatively weak. In the present invention, in order to maximize the menstrual stimulation, the surface of the suture is to present a shape that can be bent.

That is, the present invention is to improve the shape of the existing monofilament of the existing simple surface in order to give more stimulation to acupuncture points, twisting (twisting) two or more monofilaments, or to form a scratch or embossed shape on the surface I would like to present.

SUMMARY OF THE INVENTION An object of the present invention is to provide a suture structure having an appearance such as forming a scratch, embossing, or twisting two or more monofilaments on the surface of a suture used in herbal medicine for improving acupuncture stimulation effect. It is to provide a method for producing.

In order to achieve the above object, the herbal acupuncture suture thread of the present invention can be produced to smooth the surface of the suture by the following several methods.

First, by providing a regular or irregular scratch to the prepared biodegradable monofilament to maximize the stimulation of the menstrual blood to produce an improved herbal biodegradable acupuncture to give more stimulation.

Second, for biodegradable monofilament, the surface of the monofilament is roughened by attaching a powder of biodegradable polymer material to the monofilament using a biodegradable adhesive.

Third, regular or irregular embossing can be formed on the biodegradable monofilament to maximize the stimulation of menstrual blood.

Fourth, two or more biodegradable monofilaments can be twisted together to form a regular or irregular space. At this time, if the monofilament is two or more strands, the problem of fusion or adhesion of the two strands occurs, because if they are not fused to each other, they are separated individually.

The problem of separation is i) fusing two or more monofilaments with a biodegradable adhesive, ii) fusing two or more monofilaments with heat, or iii) fusing two or more filaments with ultrasonic waves, or iv) 2 Separation problems can be solved by fusion of monofilaments of strands or more using a laser.

Therefore, the configuration of the present invention is summarized as follows.

homopolymerization of glycolide, L-lactide, D-lactide, D, L-lactide, p-dioxnaone, epsilon-caprolactone, trimethylenecarbonate or combination copolymerization of glycolide and L-lactide, combination copolymerization of L-lactide and epsilon-caprolactone, Preparing monofilaments of 0.005 mm or more and 2 mm or less using two kinds of combination copolymerization or three kinds of combination copolymerization of seven monomers of (s10); And giving a scratch or sheath effect to the monofilament to give the surface a roughness (s20);

Provided is a herbal chamber manufacturing method comprising a.

In addition, homopolymerization of glycolide, L-lactide, D-lactide, D, L-lactide, p-dioxnaone, epsilon-caprolactone, trimethylenecarbonate or combination copolymerization of glycolide and L-lactide, combination copolymerization of L-lactide and epsilon-caprolactone, In addition, to prepare a monofilament using two kinds of combination copolymerization or three kinds of combination copolymerization of the above seven monomers (s100); and by attaching a poly p-dioxanone powder to the monofilament with an adhesive Giving the embossing structure (s200); Provided is a herbal chamber manufacturing method comprising a.

By attaching two or more strands of the monofilament of the rough or smooth surface prepared as described above, it is also possible to produce a suture having a curved appearance.

Among them, the coating method using a coating solution is attached to each other using a coating solution, but such attachment is performed by using i) polycaprolactone, which is a biodegradable substance alone, or ii) polyglycolide-co lactide. lactide, where lactide L; including D-, LD-) alone or iii) using a combination of these two polymers, dissolving it in methylene chloride to form a coating solution of 1 to 20 wt%. , Here, the twisted monofilament strands are immersed and dried several times in the coating solution so as to be attached.

Alternatively, two or more monofilament strands may be attached to each other by thermal fusion, and the thermal fusion may be performed by twisting monofilament strands in a oven and placing them in an oven at a melting point temperature of -20 degrees and a melting point temperature of +20 degrees for 2 to 10 minutes. There may also be a method of performing thermal fusion.

Alternatively, two or more strands may be attached to each other at predetermined intervals by a biodegradable adhesive (Loctide 4014 or Elvamide).

Alternatively, by fusion with each other by ultrasonic fusion, the fusion may be prepared by twisting the monofilament strands with each other by fusion of 0.001 seconds to 2 seconds with an ultrasonic fusion machine that generates 20,000 Hz / min at room temperature.

By this method, by significantly increasing the menstrual stimulation effect by the conventional smooth surface suture thread, the biodegradable suture can be more strongly stimulated during the time of melting inside the human body.

In other words, to improve the shape of the existing simple surface monofilament, so that the human suture for acupuncture acupuncture to stimulate the acupuncture points more, twist the two monofilaments with each other, or the surface of the thread A scratch or embossing structure was formed on the suture and a method of manufacturing the suture having a stronger acupoint structure.

1 illustrates a monofilament spinning process.
Figure 2 is a scene in which the biodegradable herbal chamber (4 strands) according to the present invention is coupled to the herbal needle.
3 is a scene in which the biodegradable herbal chamber (two strands) according to the present invention is coupled to a herbal needle.
4 and 5 is a magnified photograph 300 times that the monofilament three strands, four strands are twisted each other completed.
6, 7 and 8 are diagrams showing the structure that gave the sheath, scratch, embossing effect to the spun yarn, respectively.

USP 3-0 to 9-0 biodegradable polymer polypydioxanone (called poly p-dioxanone or less PDO) suture yarns are prepared first.

The threads may be twisted in two, three, or four strands to be attached to each other using a predetermined method so that the surface thereof may have an uneven shape.

Alternatively, the suture thread may have a scratch, sheath effect or embossing effect on the surface of the suture thread to stimulate acupuncture points more. Acupuncture points can be maximized.

In summary, we have seen how to make i) rough the suture (monofilament) by scratching it, or ii) attaching them together to make two or more strands, or iii) attaching two or more strands of monofilaments without surface roughness such as scratches. In the present invention, it is proposed. Common to these methods, as described above, is to improve the slightest menstrual stimulation of smooth monofilaments.

Hereinafter, exemplary embodiments for embodying the technical spirit of the present invention will be described in detail with reference to the accompanying drawings. The technical spirit of the present invention is not limited to the embodiments, and all inventions which can be easily modified at the level of ordinary skill in the art also fall within the scope of the present invention.

1 is a conventional monofilament manufacturing process, the following examples will be described, the conditions at each step will be described.

2 is a scene in which the biodegradable herbal chamber (4 strands) according to the present invention is coupled to a syringe needle, and the chamber is planted inside the human body, thereby stimulating menstrual blood during the process of biodegradation, thereby exerting various therapeutic effects. do.

More specifically, the biodegradable acupuncture needle (used synonymously with “chamber” here, 39) has a portion of its distal end that enters the inner hole of the syringe needle 37 and the other end of which is exposed to the outside. It is temporarily coupled to the syringe needle body via a sponge 38. If you put the syringe of Figure 2 against the human skin, only the needle is put into the body.

3 is a scene in which the biodegradable herbal chamber (two strands) according to the present invention is coupled to a needle, and FIGS. 4 and 5 are enlarged photographs of three times the monofilament strands and four strands twisted together, respectively. .

6, 7 and 8 are diagrams showing the structure that gave the sheath, scratch, embossing effect to the spun yarn, respectively. Through this process, the surface of the monofilament becomes rough, and when injected into the body, the menstrual stimulation effect is further enhanced.

In the case of FIG. 8, the fabrication of the embossed (convex portions) part is shown by taking an embossed structure by attaching poly p-dioxanone powder to the surface of the produced monofilament with an adhesive (FIG. 8 is an enlarged view of polypyridoxanone powder).

In the examples below, three methods of making monofilaments are presented, and several methods of twisting two or more strands together are described.

Example  One ( PDO  After spinning, by the adhesive of the filament strands)

A polymer chip with an inherent viscosity of 2.6 dl / g (30 ° C., 0.1% HFIP solution, where HFIP is Hexafluoroisopropanol) is called Polyp-dioxanone (hereinafter referred to as “ PDO ” ) polymer chip by the method of Table 1. Spinning to prepare USP 6-0 based on the US Food and Drug Administration suture 0.116 mm in diameter.

The single-strand suture (monofilament) is shown in Figure 1 in a simplified manufacturing process.

The suture manufacturing process of FIG. 1 is a conventionally used process, but a detailed description of the process is omitted, but the sheath / scratch / embossing process unit 50 located in the post-spinning process is a unique process of the present invention. In the step 50, the sheath, scratch, and embossing effects may be imparted to each other, or may be combined with each other to impart the effects.

The gist of the present invention is to bend or rough the smooth suture surface, and this object can be achieved in the process of the sheath / scratch / embossing process 50. In this process, the surface effect as shown in FIGS. 6 to 8 is applied, and then finally wound on the winder 36.

Even if a single-stranded monofilament gives a sheath effect or the like, it may be combined with a syringe as shown in FIG. Of course, two or more of them may be twisted together and then combined with each other to be used in a syringe.

If the sheath effect, the scratch effect, and the embossing effect (see FIG. 6 to FIG. 8) are not given (i.e., if the step 50 is omitted), the monofilament itself is a single strand. Since it is not rough, two or more strands are twisted to give surface curvature, and when used in combination with a syringe as shown in FIG.

In summary, the method of twisting two or more strands and combining them is applicable to both monofilaments with roughness such as a sheath effect and monofilaments without roughness. However, when monofilament single strands are manufactured as a chamber, a sheath on the surface After imparting roughness, such as an effect, the product can be significantly increased if it is to be commercialized.

The monofilament adhesive may be attached using Loctide 4014, which is a biodegradable adhesive, but is not limited thereto and may be any biodegradable adhesive.

As an example, the ends of the suture may be bonded every 20 mm, cut in 60 mm units, and attached (not shown). Of course, such a bonding position can be variously changed at the level of those skilled in the art. In addition, if the type of adhesive is biodegradable, of course, other adhesives can be used.

Hereinafter, Table 1 summarizes the conditions for pulling out the suture thread according to the spinning conditions of the first example.

PDO radiation conditions (see Figure 1) Item Condition Extruder Screw RPM 7.5 Tip Pressure (Kgf / cm ² ) 80 Extruder temperature
(℃) 1 zone 155 2 zone 158 3 zone 160 Nozzle Pack Temperature (℃) 160 Cooling tank temperature (℃) 23 Primary roller speed (m / min) 5.5 Primary oven temperature (℃) 80 Secondary roller speed (m / min) 35 Second oven temperature (℃) 85 3rd roller speed (m / min) 35 3rd oven temperature (℃) 90 Total draw ratio 6.3

When the terms shown in Table 1 and FIG. 1 (monofilament spinning process diagram) are described below, the extruder is a device for extruding the molten polymer through a spiral groove formed therein.

Tip pressure is a measure of the pressure exerted by the extruder 31 in FIG. This is for the purpose of measuring the discharge amount to discharge uniformly.

In Table 1, zone 1, zone 2 and zone 3 refer to the site where the temperature is measured at regular intervals by dividing from left to right on the extruder.

The nozzle pack 33 is a nozzle pack which melt | dissolves a polymer with an extruder, and a long hole of a long hole which blows out a liquid polymer is a nozzle pack, and makes an airtight holding | maintenance so that a polymer does not leak. Such a nozzle pack is necessary to obtain a seal of uniform width.

In Table 1, the total draw ratio refers to a value obtained by extending the yarn and dividing by the original length, and the drawing is made in the drawing device 35.

Using the finished suture, in order to make a finished product as shown in Figure 2, the suture is inserted into the hole of the disposable syringe needle end and fixed with a sponge. Furthermore, in order to package the product, the product is placed in primary Tyvek sterile paper and heat-sealed with a tower packing machine (not shown). Subsequently, it is put into an aluminum pouch in a second place and sterilized by EO (hereinafter referred to as EO). After sterilization, heat-bonded secondary aluminum wrappers are packaged to complete the final packaging.

Example  2 ( PGLA  After spinning, by the adhesive of the filament strands)

In this embodiment, an example of spinning is performed with different materials serving as suture materials. Other content is applicable in the same manner as described in the first embodiment.

For monofilament spinning, PGLA (Poly glycolide-co-L-lactide, where the molar ratio of glycolide and L-lactide is 9: 1) polymer chip (high viscosity: 1.5 dl / g, 30 degrees Celsius, 0.1% HFIP conditions) USP 6-0 having a diameter of 0.116 mm was prepared using a mono-radiator.

A braided suture was produced by twisting two strands using this biodegradable suture. Loctide 4014, which is a 2-strand twister suture biodegradable adhesive, was bonded to both ends every 20 mm, cut in units of 60 mm, and the prepared suture was sandwiched between syringe needles and fixed with a sponge. Of course, the adhesive position may be modified in various ways.

By twisting two or more strands and bonding them with an adhesive, both a monofilament with a roughness such as a sheath effect and a monofilament without a roughness are applicable, but when a monofilament single strand is commercialized into a chamber, a sheath on the surface After giving roughness and other effects, it will be commercialized.

In addition, the biodegradable needles for herbal medicine may be prepared by twisting three, four or five strands together using an adhesive.

PGLA emission conditions (see Figure 1) Item Condition Extruder Screw RPM 7.5 Tip Pressure (Kgf / cm ² ) 80 Extruder temperature
(℃) 1 zone 225 2 zone 230 3 zone 230 Nozzle Pack Temperature (℃) 230 Cooling tank temperature (℃) 23 Primary roller speed (m / min) 5.5 Primary oven temperature (℃) 80 Secondary roller speed (m / min) 30 Second oven temperature (℃) 85 3rd roller speed (m / min) 35 3rd oven temperature (℃) 90 Total draw ratio 6.3

Meanwhile, as shown in FIGS. 6 to 8, two or more strands of monofilament having rough surfaces may be bonded to each other by using an adhesive as in the present embodiment.

Example  3 ( PGCL  After spinning, bonding by adhesive of filament strands)

In this embodiment, a single strand production by PGCL spinning and an example of twisting two or more strands with an adhesive will be described.

In other words, PGCL (poly glycolide-co-epsilon caprolactone, where the molar ratio of glycolide and epsilon caprolactone is 75:25) is 0.117mm using a mono-radiator with a polymer chip (high viscosity 1.6dl / g, 30 degrees Celsius, 0.1% HFIP). USP 6-0 was prepared. Braided sutures were prepared by twisting two strands using this biodegradable suture yarn.

In order to achieve the object of the present invention, by twisting two strands of the single strand prepared as described above, using a biodegradable adhesive Loctide 4014 was bonded to the sock end every 20 mm, and cut in 60 mm units.

Of course, the chamber can also be manufactured by twisting three or more strands in the same manner.

PGCL emission conditions Item Condition Extruder Screw RPM 7.5 Tip Pressure (Kgf / cm ² ) 80 Extruder temperature
(℃) 1 zone 235 2 zone 240 3 zone 240 Nozzle Pack Temperature (℃) 240 Cooling tank temperature (℃) 23 Primary roller speed (m / min) 5.5 Primary oven temperature (℃) 80 Secondary roller speed (m / min) 35 Second oven temperature (℃) 85 3rd roller speed (m / min) 40 3rd oven temperature (℃) 90 Total draw ratio 7.2

Meanwhile, as shown in FIGS. 6 to 8, two or more strands of monofilament having rough surfaces may be bonded to each other by using an adhesive as in the present embodiment.

In this embodiment as well as in Example 1 it is possible to make a finished product that can be sold through the same packaging process.

Example  4 (more than 2 strands Monofilament  Bonding by coating solution)

In the present embodiment, unlike Examples 1 to 3 will be described an example in which two or more strands are attached by a coating solution rather than an adhesive.

That is, after preparing the monofilament in the same manner as in Example 1, two strands of biodegradable suture yarn USP 6-0 can be twisted, and the two strands can be attached using a coating solution.

First, use biodegradable polycaprolactone alone,

Using polyglycolide-co-lactide, where lactide L; including D-, LD- alone or in combination of the two polymers,

It is dissolved in methylene chloride to form a coating solution of 1 to 20 wt%, and the twisted monofilament strands are immersed and dried several times in the coating solution, followed by two strands of twisted mono. Coating the filament. At this time, the thickness of the coating is preferably set to 2 ~ 300 ㎛.

6 to 8, the two or more strands of monofilament having a rough surface may be bonded by the coating liquid according to the present embodiment by providing a sheath effect and the like.

Then, EO sterilization in the same manner as in Example 1 to complete the preparation of biodegradable needles for herbal medicine.

Example  5 (more than 2 strands Monofilament  Heat In fusion  Combined)

Unlike in the case of Examples 1 to 3, the present embodiment will describe an embodiment in which two or more strands are attached by a thermal fusion method rather than an adhesive.

In the same manner as in Example 1 to prepare a monofilament of a single strand suture, twisted two strands of biodegradable suture yarn USP 6-0, and then heat the hot wire can be fused to the twisted strand.

In the welding, the welding conditions are two strands by twisting two strands of spin-produced PDO USP 6-0 into an oven and heating at a melting point temperature of 85 to 125 degrees Celsius (± 20 degrees) for 2 to 10 minutes. It is possible to heat-bond the twisted monofilament of. Of course, it is also possible to fuse three or more strands by the above method.

6 to 8 may give a sheath effect or the like and thermally bond two or more strands of the monofilament having rough surfaces to each other.

Then, EO sterilization in the same manner as in Example 1 to complete the preparation of biodegradable needles for herbal medicine.

Example  6 (more than 2 strands Monofilament  ultrasonic wave In fusion  Combined)

In this embodiment, a method of joining two or more strands together by ultrasonic fusion is presented.

It prepared in the same manner as in Example 1. Only braided sutures were prepared by twisting two strands of biodegradable suture yarn USP 6-0. Bond using ultrasonic welding.

Ultrasonic fusion can be performed by fusion of two strands of PDO USP 6-0 produced by spinning, with an ultrasonic fusion device generating 20,000 Hz / min at room temperature in 0.001 sec to 2 sec to fusion two twisted monofilaments.

6 to 8 may be combined with each other by ultrasonic welding according to the present embodiment by giving a sheath effect or the like, and having two or more roughly monofilament strands.

Then, by EO sterilization in the same manner as in Example 1 it is possible to complete the preparation of biodegradable needles for herbal medicine.

Hereinafter, the physical properties of the chambers according to the above examples are shown in Table 4.

Property results Example diameter
(mm) Early EP Knot
strong
(Kgf / cm ² ) Initial EP Knot Strength (%) after 2 weeks
Knot strength
(Kgf / cm ² ) 2 weeks later EP
knot
strong(%) EP knot strength after 4 weeks
(Kgf / cm ² ) EP knot after 4 weeks
strong(%) Example 1 0.116 0.47 100 0.40 86 0.39 84 Example 2 0.116 0.43 100 0.31 72 - - Example 3 0.117 0.79 100 0.15 19 - - Example 1
in
Scratch effect 0.116 0.44 100 0.39 88 0.37 84 Example 1
Sheath
effect 0.116 0.43 100 0.38 88 0.35 81 Example 1
in
Embossing
effect 0.118 0.47 100 0.41 87 0.40 85

The measuring method of the said physical property was performed as follows.

First, the diameter measurement method was measured by the US Food and Drug Administration's USP 921 (referred to as USP below United States Pharmaceutia), and the measuring device was measured by applying tension to the suture of the multifilament using Mitutoyo dialel gaze. In addition, the suture thread was measured once and then rotated at an angle of 90 degrees, and ten measurements were taken as average values.

Second, in the EP (European Pharmaceutia or less) knot measurement method, the surgical suture was knotted once using Instron's tensile strength device, and five measured values were averaged using the EP simple knot method. .

Third, knot strength retention method: measure the initial EP knot strength of the manufactured suture. Then 1M phosphate buffered (phosphate buffered saline) was prepared to pH 7.4. Put about 2m of the suture prepared in the test tube and fill it with 1M phosphate buffered saline to lock the suture. After adjusting the temperature of the shaking bath to 37 ° C., the prepared test tube was put in and taken out after 14 or 28 days, and the EP knot strength was measured to calculate the knot strength retention.

On the other hand, although not described in the above embodiments, using a biodegradable multifilament FDY (fully drawn yarn) of 50 mm or less at a diameter of one strand or more, more than 1 to 5000 bundles of the short fibers of the present invention It may be possible to achieve the purpose.

31: Extruder 32: Die head
34: cooling tank 35; drawing device 36: winder
37: syringe needle 38: sponge
39: 4 strands acupuncture chamber 40: syringe needle handle part
50: sheath / scratch / embossing process part 51: carrier

Claims (6)

In the chamber manufacturing method that is injected into the human body through the herbal biodegradable acupuncture,

Glycolide, L-lactide, D-lactide, Di-lactide, P-dioxnaone, epsilon-caprolactone , Homopolymerization of trimethylene carbonate or combination copolymerization of glycolide and l-lactide,
Combination copolymerization of L-lactide and epsilon-caprolactone, and two or more combination copolymers or three combination copolymer polymers of the above seven monomers to spin and monofilament diameter of 0.005 mm or more Preparing monofilaments of 2 mm or less (s10);
Giving a scratch or sheath effect to the monofilament to impart a roughness to the surface (s20);
Herbal chamber manufacturing method comprising a.
In the chamber manufacturing method that is injected into the human body through the herbal biodegradable acupuncture,
Glycolide, L-lactide, D-lactide, Di-lactide, P-dioxnaone, epsilon-caprolactone , Homopolymerization of trimethylene carbonate or combination copolymerization of glycolide and l-lactide,
Combination copolymerization of L-lactide and epsilon-caprolactone, and two or more combination copolymers or three combination copolymer polymers of the above seven monomers to spin and monofilament diameter of 0.005 mm or more Preparing monofilaments of 2 mm or less (s10);
Attaching a poly p-dioxanone powder to the monofilament with a biodegradable adhesive to give an embossed structure (s200);
Herbal chamber manufacturing method comprising a.
After twisting the chamber prepared by claim 1 or 2, or two or more strands of monofilament prepared in step s10 of claim 1 with each other,
Attach to each other using a coating solution, such attachment,
Use polycaprolactone, a biodegradable substance, or
Using polyglycolide-co-lactide, where lactide L; including D-, LD- alone,
Or a combination of these two polymers,
It is dissolved in methylene chloride to form a coating solution of 1 to 20 wt%, wherein the twisted monofilament strands are
Characterized in that the adhesion is made by immersing and drying the coating solution several times,
Chinese medicine chamber manufacturing method.
Claim 1 or 2, or two or more monofilament prepared in step s10 of claim 1 attached to each other by thermal fusion,
The heat fusion is characterized in that the twisted monofilament strands, put into the oven, and heat fusion for 2 to 10 minutes at a melting point temperature of 85 degrees to 125 degrees (± 20 degrees) section,
Chinese medicine chamber manufacturing method.
The chamber prepared by claim 1 or 2, or two or more monofilament prepared in step s10 of claim 1 is formed by attaching to each other at predetermined intervals by a biodegradable adhesive (Loctide 4014 or Elvamide),
Chinese medicine chamber manufacturing method.
The chamber prepared according to claim 1 or 2, or two or more monofilament prepared in step s10 of claim 1 are fused to each other by ultrasonic welding,
The fusion is characterized in that the monofilament strands are twisted with each other, fusion of 0.001 seconds to 2 seconds with an ultrasonic fusion device that generates 20,000 Hz / min at room temperature,
Chinese medicine chamber manufacturing method.

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