KR101135361B1 - composition of toothpaste for checking condition of body - Google Patents

Abstract

The present invention can be added to the components of the toothpaste to react with the acid and alkali indicator components to check the state of the indicator components reacting with saliva during the brushing process and furthermore, most cancer patients using the saliva showing the acidic The present invention relates to a toothpaste composition for human condition check, which can be used as an early warning toothpaste that shows an alarm against the occurrence of cancer in the human body by checking acidic saliva.

Toothpaste composition for human condition check

Description

Composition of toothpaste for checking condition of body

The present invention relates to a toothpaste composition for checking the condition of the human body, and more particularly, an indicator component reacting with an acid and an alkali may be added to the component of the toothpaste to check the state of the indicator component reacting with saliva in the brushing process. The present invention relates to a toothpaste composition for checking a human condition, which can be used as an early warning toothpaste that shows an alarm against cancer of the human body by checking acidity of the cancer patient's saliva by using most of the saliva of the cancer patient.

Litmus paper is an indicator and finds acid, basic and neutral. Litmus paper reacts red to acid, colorless to neutral, and blue to basic. Litmus paper is an indicator made from litmus moss. Litmus paper responds to pH levels, and pH values are hydrogen ion concentrations, which are divided into acidic, neutral and basic depending on the amount of hydrogen ions in the solution. ph 7 is called neutral, if lower, it is acidic, if high it is basic. Acid is contained as hydrogen ion in hydrochloric acid, sulfuric acid, nitric acid, vinegar, glacial acetic acid, lemon, apple, grape, cider, beer, insect poison, etc., and basicity is soap, detergent, soda, fabric softener, sodium hydroxide, calcium hydroxide, lime water, etc. It is contained in hydroxide ions.

Indicators that act like litmus paper include methyl orange and phenolphthalein solutions. Methyl orange reacts red in acid, green in neutral and yellow in basic. The phenolphthalein solution reacts colorlessly to acidic and neutral and red to basic. In addition, a solution of boiling morning glory or cabbage can serve as an indicator.

Phenolphthalein solution is a representative neutralizing stop reagent used in chemical analysis and is also called adsorption indicator or phthalein dye. 1871 J.F.W.A. Buyer first made. Sublimate at boiling point 262 ～ 264 ℃. Colorless crystals, insoluble in water but soluble in ethyl alcohol. Condensation can be obtained by adding concentrated sulfuric acid to phthalic anhydride and phenol. When used as an indicator, generally 1% ethyl alcohol solution. In acidic color, it is colorless to lactone, but becomes a disodium salt (planar structure) at a pH of 9 to a red color. If the base becomes stronger, it becomes trisodium salt and becomes carbinol type, so that it cannot take a planar structure and becomes colorless again. The reason for discoloration is that due to the change of structure in alkaline, chromophore is generated in the molecule. An acid base reagent used to indicate the endpoint of neutralization titration. Discoloration in the range of pH 8.2∼10.0, acidic colorless and basic color red

Methyl orange is also one of the monoazo dyes and is also referred to as 4'-dimetalaminoazobenzene-4'-sulfonic acid sodium. Diazosulfated sulfanic acid to dimethylaniline

Obtained by coupling to sodium salts with sodium hydroxide. Orange powder or scaly crystals. Soluble in water and alcohol, insoluble in ethanol. It discolors in the range of pH3.1 (red) to 4.4 (yellow). Widely used as acidic indicator.

Conventional health checkups must be carried out in a specialized medical institution, which takes a lot of time and money and can not check their own health at an early stage. The human body exposed to various harmful environments and stresses gradually oxidizes, and the oxidized human body is accompanied by a red light on the health wire and creates a condition in which cancer can occur. Toothpaste is a component of toothpaste that reacts with acid and alkali in the toothpaste process. You can check your condition, early detection of cancer, including health conditions, and contribute to oral health. Acid constitution regulates the pH of living organisms by causing cancer. You can brush your teeth every day and live a healthy life in a consistent, healthy condition.

The present invention should be carried out in a medical institution, such as cancer, but it takes time and money, and improves the problem of not being able to check his / her health condition early. The present invention relates to a toothpaste composition for checking a human condition that can check the state of an indicator component reacting with saliva in a gargling process by adding an indicator component reacting with an acid and an alkali. The present invention is to manufacture a toothpaste that detects cancer early and because the saliva of cancer patients are oxidized, when brushed with litmus toothpaste can determine the presence of abnormal conditions, including cancer and the color of the toothpaste one day The aim is to produce toothpaste that can be freed from the high costs and pains of maintaining health by taking action on health status early.

The present invention is an acid-based indicator component selected from litmus moss, a raw material of litmus paper, monoazo dye 4'-dimetalaminoazobenzene-4'-sodium sulfonate and phthalein dye, which is a raw material of phenolphthalein solution. It relates to a toothpaste composition for human condition check characterized in that it contains 0.001 to 3.00% by weight of the total weight of the toothpaste composition.

Toothpaste for checking the condition of the human body of the present invention is a toothpaste for checking the condition of the human body that can perform a health check, such as a simple human condition check in the process of brushing teeth simply using toothpaste instead of performing a health checkup such as cancer in a specialized medical institution It can be used as a cancer early warning dentifrice which can be used to check the acidity of the cancer patient's saliva by using the acidity of most cancer patients' saliva.

The present invention is one of the acidic indicators selected from litmus lichen powder which is a raw material of litmus paper, monoazo dye 4'-dimetalaminoazobenzene-4'-sodium sulfonate which is a raw material of methyl orange and phthalein dye which is a raw material of phenolphthalein solution. It relates to a toothpaste composition for human condition check, characterized in that the component is contained 0.001 to 3.00% by weight of the total weight of the toothpaste composition.

Toothpaste composition for human condition check of the present invention is characterized in that the pH of the patient to check the saliva of the human body to indicate an alarm for cancer.

Toothpaste for checking the condition of the human body of the present invention is a toothpaste for checking the condition of the human body that can perform a health check, such as a simple human condition check in the process of brushing teeth simply using toothpaste instead of performing a health checkup such as cancer in a specialized medical institution It can be used as a cancer early warning dentifrice which is used to indicate the acidity of the cancer patient's saliva by using most of the cancer patient's saliva indicates acidic.

The saliva of cancer patients shows acidity of about PH 4, litmus moss, a raw material of litmus paper, monoazo dye 4'-dimetalaminoazobenzene-4'-sodium sulfonate, and phthalate dye, a raw material of phenolphthalein solution. When using a toothpaste for checking the condition of the human body containing any of the acid-based indicator component selected from among the simple check can be carried out early check for cancer without regard to a specific place.

The abrasive used in the present invention may be precipitated silica, calcium dihydrogen phosphate, hydrous alumina,

Any one selected from hard calcium carbonate, calcium pyrophosphate and silica gel can be used. The humectant used in the present invention may be any one selected from concentrated glycerin (98%), aqueous sorbitol solution (70%), and zyritol. The foaming agent used in the present invention may be used any one selected from sodium lauryl carbonate and poloxamer. The drug used in the present invention (F 0.1%) may be used any one selected from sodium phosphate fluoride and sodium fluoride. As the additive used in the present invention, any one selected from fragrance, saccharin and titanium oxide may be used. The binder used in the present invention may use any one selected from gellan gum, xanthan gum, carrageenan and sodium carboxymethylcellulose.

Typical toothpaste compositions basically comprise a mixture of an abrasive of insoluble inorganic powder and a water-compatible solution, including water soluble raw materials and water. In general toothpaste, the insoluble powder and liquid phase are separated by the difference in specific gravity of each raw material when the mixture is left after mixing, and the insoluble powder precipitates, making usability very poor. Accordingly, a thickener or binder is included to form a viscosity to prevent separation. In particular, binders are mainly used in water-soluble polymers, which are increased by water to form or gel the toothpaste composition, thereby preventing the separation of insoluble solids and liquid phase from the toothpaste components. In addition, in the toothpaste composition, in addition to preventing the separation of the toothpaste components, the binder affects the physical properties such as toothpaste retention, transparency, extrusion property from the toothpaste tube, and loosening when brushing. It also affects the efficacy and effect of achieving. Here, the toothpaste prosthesis is a property of discharging the toothpaste on the bristles to maintain the original form of the toothpaste without flowing down on the toothbrush when used. The higher the prosthesis, the higher the emotional satisfaction of the user.

Water-soluble polymers used as binders of toothpaste include carboxymethyl cellulose salt, xanthan gum, carrageenan, alginate salt, carbopol and the like. The conventional toothpaste composition has a problem that the binder is contained at a high concentration. The use of binders of water-soluble polymers prevents the separation of toothpaste components, and provides a high concentration of binders to provide the benefits of toothpaste retention, transparency, extrudability from toothpaste tubes, and loosening and drug delivery. It is contained. In addition, the binder of the water-soluble polymer is inferior in stability to heat and acid, and does not have an excellent effect compared to the amount of use in terms of physical properties such as drug delivery properties, shape retention, and annealing properties.

The toothpaste composition of the present invention contains, as an essential base component, a water-soluble humectant which has an abrasive insoluble inorganic powder and an ointment (paste) formulation. Conventional toothpaste compositions can be used as binders by mixing with one or more selected from the group consisting of carboxymethylcellulose salts, carrageenan, xanthan gum, alginates and carbopol. The abrasive used in the present invention comprises a group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, calcium dihydrogen phosphate anhydrous, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate. At least one selected from, the amount of use is contained 5 to 50% by weight of the total weight of the toothpaste composition. At this time, less than 5% by weight of the tooth polishing effect is insignificant, when more than 50% by weight may cause wear of the teeth by excessive polishing. In addition, the polishing degree of the final product (toothpaste composition) is to exhibit a value of 30 to 100. The particle size may vary depending on the type of abrasive, but it is preferable to use one having an average particle diameter of 20 micrometers or less. The polishing value is a relative polishing degree starting from 0 with a standard toothpaste of 100. In general, most products (toothpaste) have a value of 200 or less.

Wetting agent is an essential ingredient to make ointment (paste) formulations, which prevents toothpaste from drying and solidifying when exposed to air, provides shine to the surface of toothpaste, and also gives sweetening effect to some types of teeth. Do it. Wetting agent used in the present invention 1 selected from the group consisting of concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), xylitol, polyethylene glycols and propylene glycol It is a species or more, and the usage-amount is contained 20 to 70 weight% with respect to the total weight of a toothpaste composition.

In addition, the toothpaste composition of the present invention may contain a suitable medicinal ingredient as usual according to the purpose of use, as the cavities prevention component is one or more selected from sodium phosphate, sodium fluoride, amine fluoride and tin fluoride as fluoride It may be contained. At this time, the content of fluorine in the product (toothpaste composition) is to be 1,500ppm or less. In addition to the caries prevention component, enzymes may also be included for the purpose of suppressing and removing cationic surfactants or plaques for the purpose of sterilizing bacteria in the oral cavity. In addition, in order to prevent periodontal disease, water-soluble salts such as sodium chloride or sodium bicarbonate having high osmotic pressure, aminocapronic acid, allantoin and allantoin derivatives having hemostatic action, and various vitamins may be selectively contained.

In addition, a foaming agent may be included to enhance the feeling of use of the product (toothpaste composition), to help the cleaning action, to quickly disperse and infiltrate other active ingredients, and to reduce the interfacial tension so that foreign substances in the oral cavity easily come off. As the foaming agent, sodium lauryl sulfate, an anionic surfactant, may be used, and a copolymer of polyoxyethylene polyoxypropylene (poloxamer), which is a nonionic surfactant, may be used depending on the characteristics of the formulation. One or more types selected from polyoxyethylene sorbitan fatty acid esters and the like may additionally be contained. In addition, the toothpaste composition of the present invention may optionally contain flavors, sweeteners and pigments, etc. in order to improve the feeling of use, and as the flavoring edible flavorings, peppermint oil, spearmint oil, sage, eucalyptol, methyl Salicylate and fruit extract. As the sweetener, sodium saccharin may be used as an example, and food coloring may be used as the dye. As a result of comparing and evaluating the toothpaste composition of the present invention composed of the above components and the existing commercially available toothpaste in various aspects, the toothpaste composition according to the present invention was much superior in physical properties and stability.

Example 1

The toothpaste composition of the present invention was prepared by first dispersing a binder in a humectant mixed with a solvent, dispersing and mixing other components (pharmaceuticals, additives, solvents), and then stirring the abrasive for about 30 minutes. And after adding the foaming agent, the resultant was stirred for 20 minutes in a vacuum state to obtain a final product. The ingredients used were y% of precipitated silica 20, abrasive, 45% by weight of concentrated glycerin (98%), 2% by weight of sodium lauryl carbonate as a foaming agent, 0.22% by weight of sodium fluoride as an agent (F 0.1%), perfume 1% by weight, 0.1% by weight of saccharin, 0.3% by weight of titanium oxide, 0.3% by weight of litmus moss, and the remaining purified water were used.

Example 2

Instead of using 0.3% by weight of litmus moss in Example 1 was prepared in the same manner using 0.3% by weight of monoazo dye 4'-dimetalaminoazobenzene-4'-sodium sulfonate as a raw material of methyl orange.

Example 3

Instead of using 0.3% by weight of litmus moss in Example 1 was prepared in the same manner using 0.3% by weight of phthalein dye as a raw material of the phenolphthalein solution.

Experimental Example 1

The toothpaste prepared in Example 1 was used to evaluate physical properties and stability. Each toothpaste composition was dispensed by 2 centimeters on the same type of toothbrush, and 50 experienced test subjects performed a medical examination such as a simple human condition check in the process of brushing teeth using toothpaste. In response to the acidic reaction, the cancer patient's saliva reacted with red color to check the acidity and early warning of cancer was indicated to indicate the alarm for human cancer.

Experimental Example 2

The toothpaste prepared in Example 1 was confirmed to be acidic by reacting red to the saliva of cancer patients, and evaluated whether the cancer early warning toothpaste that indicates an alarm for human cancer.

Claims (2)

The acid-based indicator component of litmus lichen powder, which is a raw material of litmus paper, is contained in 3.00 wt% of the total weight of the toothpaste composition, and the pH of the patient's saliva is checked as an acid of pH 4 to indicate an alarm for human cancer. Toothpaste composition for human body condition check. delete