KR101126630B1 - Measuring devices in parkinson's disease - Google Patents

Measuring devices in parkinson's disease Download PDF

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KR101126630B1
KR101126630B1 KR1020100121762A KR20100121762A KR101126630B1 KR 101126630 B1 KR101126630 B1 KR 101126630B1 KR 1020100121762 A KR1020100121762 A KR 1020100121762A KR 20100121762 A KR20100121762 A KR 20100121762A KR 101126630 B1 KR101126630 B1 KR 101126630B1
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parkinson
disease
sensor unit
main body
treatment
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문성대
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(주)힐닉스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1101—Detecting tremor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0431—Portable apparatus, e.g. comprising a handle or case

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Abstract

PURPOSE: A measuring devices in a parkinson's disease is provided to easily measure a treatment result by checking the number of hand trembling and the speed and pressure thereof gradually in recovery. CONSTITUTION: A main body(200) is composed of a rounded rod type so that a patent grips the body. A gyro sensor part measures the vibration of a hand inside the main body. An acceleration sensor measures the speed of the trembling in the center of the body. A pressure sensor unit(500) measures pressure while the patent grips the body. A guide line(600) is lead to outside through the inside of the body.

Description

파킨슨 질환 진단용 측정장치{Measuring devices in Parkinson′s disease}Measuring device for Parkinson's disease {Measuring devices in Parkinson's disease}

본 발명은 파킨슨 질환 진단 측정장치에 관한 것으로서, 보다 상세하게는 파킨슨 질환 환자의 회복을 위한 치료 시 손의 떨림 횟수, 속도, 압력 등을 단계적으로 체크할 수 있는 파킨슨 질환 진단 측정장치에 관한 것이다.The present invention relates to an apparatus for diagnosing Parkinson's disease. More particularly, the present invention relates to an apparatus for diagnosing Parkinson's disease, which can check step counts, speeds, and pressures of hands during treatment for recovery of Parkinson's disease patients.

파킨슨병은 진전(떨림), 경직, 서동증(행동이 느려짐), 불안정한 자세 유지 등을 주증상으로 하는 병으로 뇌에서 도파민이라는 신경전달물질이 부족하게 되어 생기는 만성질환이며, 상기 도파민은 뇌의 흑색질이라는 신경세포에서 생성되며 흑색질의 신경세포는 뇌의 기저핵이라는 부위와 연결되며, 기저핵은 뇌의 운동피질 및 기타 여러 부위와 복잡하게 연결되어 있어 인체의 운동을 부드럽고 조화있게, 또한 정확하게 수행할 수 있도록 해주는 매우 중요한 부위이다.Parkinson's disease is a chronic disease caused by lack of a neurotransmitter called dopamine in the brain. It is a symptom with tremor, tremor, stiffness, slow motion, and unstable posture. It is produced by the nerve cells called, and the black cells of the nerve cells are connected to the part of the basal nucleus of the brain, and the basal nucleus is complexly connected to the motor cortex and other parts of the brain so that the body's movements can be smoothly, harmonized and accurately performed. It is a very important part.

파킨슨병은 흑색질에서 기저핵의 기능을 조절하기 위하여 분비되는 물질인 도파민이 부족하면 나타나게 되는 것으로, 현재 사용되고 있는 상당수의 치료 약물은 부족해진 도파민을 보충하거나 그 작용을 도와줄 수 있는 것들이다. 그러나 흑색질 신경세포의 파괴가 뚜렷하지 않은 경우에도 파킨슨병에서 보이는 증상들이 나타날 수 있는데 이러한 경우를 병이라 하지 않고 "파킨슨 증후군"이라 부르며, 여기에는 여러 가지 원인이 있으나 뇌종양, 복싱선수처럼 머리에 충격을 자주 받는 경우, 정신병 치료에 쓰이는 정신안정제, 망간이나 일산화탄소 중독증 등이 대표적으로 알려져 있다.Parkinson's disease is caused by the lack of dopamine, a substance secreted to control the function of the basal ganglia in black matter, and many of the therapeutic drugs currently in use are those that can supplement or help the lack of dopamine. However, even if the destruction of melanocyte neurons is not obvious, the symptoms seen in Parkinson's disease may appear. These cases are not called diseases, but are called "Parkinson's syndrome." There are many causes, but there are many causes such as brain tumors and boxers. If you get frequent, mental stabilizers used to treat psychosis, manganese or carbon monoxide poisoning, etc. are known.

이러한 파킨슨 환자의 5-10%는 가족성 유전적 요인으로 분류되어지고 있다. 최근에는 파킨슨 관련 유전자들의 역할이 분자 생물학적 수준에서 밝혀지고 있으며, 약물치료의 타겟 선정이나 치료제 개발에서 관련 유전자의 규명이 매우 중요하게 평가되고 있다. 따라서 파킨슨에 관여하는 치료제, 및 치료 방법 개발을 위한 스크리닝에서 관련 유전자의 발현 정도의 차이를 밝히는 일은 염증성 질환의 진단, 치료, 예방 에 있어서 매우 중요한 사항으로5-10% of these Parkinson's patients are classified as familial genetic factors. Recently, the role of Parkinson-related genes has been revealed at the molecular and biological level, and the identification of related genes has been very important in the targeting of drug therapy and the development of therapeutics. Therefore, it is very important for the diagnosis, treatment and prevention of inflammatory diseases to identify the difference in the expression level of related genes in screening for the development of therapeutics and treatment methods.

평가 받고 있다.I am evaluated.

이러한, 치료 및 예방을 위해 약물적인 치료측정법을 사용하고 있는데 디엔에이 마이크로어레이 시스템은 어레이상에 집적된 생분자(bio-molecules)에 따라 올리고뉴클레오티드 마이크로어레이, 시디엔에이 (cDNA) 마이크로어레이, 및 게놈 마이크로어레이로 분류된다. 그 중 시디엔에이 마이크로어레이 칩은 제작이 간편하며, 비교적 쉽게 콘텐츠의 확보와 이에 따른 질병 특이적 칩을 제작함으로써 간단하고, 효과적으로 질병의 유무를 예측 판단할 수 있게 한다.These pharmacotherapeutic methods are used for treatment and prevention. The DNA microarray system uses oligonucleotide microarrays, cDNA microarrays, and genomes according to bio-molecules integrated on an array. It is classified as a microarray. Among them, the CDNA microarray chip is easy to manufacture, and it is possible to easily and effectively predict the presence or absence of disease by securing contents and making disease-specific chips accordingly.

따라서 파킨슨 질환을 스크리닝 할 수 있도록 고안된 cDNA 마이크로어레이 칩은 파킨슨 질환의 예방, 진단, 및 치료에 유용하게 사용 될 수 있으며, 이러한 칩의 사용으로 파킨슨 질환에 관여하는 유전자 발현의 변화를 측정하는 한편, 파킨슨 질환에 있어서의 신호전달 메카니즘(mechanism)까지 확인 할 수 있게 되어, 파킨슨 및 파킨슨 유사 질환의 연구 및 치료에 있어서 유용한 도구로 사용할 수 있다. 그러나 아직까지 파킨슨 질환의 진단에 관련된 체계적이고 유용한 칩은 개발되지 않은 상태이다.Therefore, cDNA microarray chips designed to screen Parkinson's disease can be useful for the prevention, diagnosis, and treatment of Parkinson's disease, and the use of these chips can measure changes in gene expression involved in Parkinson's disease. Signaling mechanisms in Parkinson's disease can be identified, which can be used as a useful tool in the research and treatment of Parkinson's and Parkinson's-like diseases. However, no systematic and useful chips related to the diagnosis of Parkinson's disease have yet been developed.

이에, 본 발명은 상술한 약물적인 치료측정법과는 달리, 파킨슨 질환을 진단받은 환자가 치료중에 치료받는 치료에는 약물적 치료, 수술적 치료 또는 물리적 치료가 있는데 이러한 치료에 따른 치료결과 또는 치료경과의 결과를 알아보기 위해 간편한 측정장치가 필요한 실정이다.Accordingly, the present invention, unlike the above-described pharmacotherapeutic measures, the treatment of the patient diagnosed with Parkinson's disease is treated during the treatment is pharmacological treatment, surgical treatment or physical treatment according to the treatment result or treatment history A simple measuring device is needed to check the results.

상기와 같은 파킨슨 질환의 환자에 따른 치료결과를 측정하기 위한 본 발명의 목적은, 진단받은 파킨슨 질환 환자들의 증상에 대한 약물적 치료, 수술적 치료 또는 물리적 치료에 따라 치료결과의 수치를 확인할 수 있도록 하는 물리적인 측정장치로서 환자의 손에 쥐고 측정할 수 있도록 환봉형을 가지고, 일정한 단위시간에 손의 떨림, 이동속도 및 압력을 측정하여 치료결과를 주기적으로 쉽고 간단하게 측정하여 치료효과과정을 알아 볼 수 있도록 하는 파킨슨 질환 진단용 측정장치를 제공하는 것이다.An object of the present invention for measuring the treatment results according to the patients with Parkinson's disease as described above, so as to determine the level of the treatment result according to the pharmacological treatment, surgical treatment or physical treatment for the symptoms of the diagnosed Parkinson's disease patients It is a physical measuring device that has a round bar type so that it can be measured by holding it in the hand of a patient and measures the shaking, movement speed and pressure of the hand at a certain unit time to periodically and easily measure the treatment result to know the treatment effect process. The present invention provides a measuring device for diagnosing Parkinson's disease.

본 발명의 구성에 있어 파킨슨 질환의 환자의 손에 쥘 수 있도록 환봉형의 본체와,In the configuration of the present invention, the body of the round bar type so that it can be held in the hands of patients with Parkinson's disease,

상기 본체 내부의 하부에 손 떨림을 측정하는 자이로센서부와,A gyro sensor unit for measuring hand shaking in the lower part of the main body;

상기 본체 내부의 중간부에 손의 이동속도를 측정하는 가속도 센서부와,An acceleration sensor unit measuring a moving speed of a hand at an intermediate portion inside the main body;

상기 본체 외주면에 상기 본체를 쥐고 있는 동안 압력을 측정하는 복수개의 압력센서부와,A plurality of pressure sensor units for measuring pressure while holding the main body on the outer peripheral surface of the main body;

상기 자이로센서부, 가속도센서부 및 압력센서부의 각각에 연결되어 신호를 전달하도록 본체 내부를 통해 외부로 인가되는 유도선으로 구성되는 파킨슨 질환 진단용 측정장치를 제공한다.
It is connected to each of the gyro sensor unit, the acceleration sensor unit and the pressure sensor unit provides a Parkinson's disease diagnosis measuring device consisting of a guide line applied to the outside through the body to transmit a signal.

한편, 상기 자이로센서부, 가속도센서부 및 압력센서부의 각각에 연결되어 신호를 유도선을 통해 제어매체인 컴퓨터 또는 스마트폰 중 택일하여 유/무선으로 전달되도록 하는 파킨슨 질환 진단용 측정장치를 제공한다.On the other hand, it is connected to each of the gyro sensor unit, the acceleration sensor unit and the pressure sensor unit provides a measurement device for Parkinson's disease diagnosis to transmit the signal to the wired / wireless by selecting either a computer or a smartphone that is a control medium through a guide line.

상술한 바와 같이 이상과 같이 본 발명은 파킨슨 질환 환자 등과 같이 마비 증세가 있는 환자의 치료에 사용되는 측정기기에, 치료과정중 즉시 환자의 손 떨림, 이동속도 및 압력을 측정할 수 있게 되어 환자의 치료상태 및 치료경과를 주기적으로 알 수 있어 환자 치료를 보다 계획적으로 할 수 있는 이점이 있는 것이다.As described above, the present invention is a measuring device used for the treatment of patients with paralysis, such as Parkinson's disease patients, it is possible to immediately measure the hand shaking, moving speed and pressure of the patient during the treatment process The treatment status and the progress of the treatment can be known periodically, so there is an advantage that can be planned more patiently.

도 1은 본 발명에 따른 파킨슨 질환 진단용 측정장치의 사시도.
도 2는 본 발명에 따른 파킨슨 질환 진단용 측정장치의 내부 구조도.
도 3은 본 발명에 따른 파킨슨 질환 진단용 측정장치와 유/무선으로 연계되어 측정값을 전달하는 공정도.1 is a perspective view of a measuring device for diagnosing Parkinson's disease according to the present invention.
Figure 2 is an internal structure diagram of a measuring device for diagnosing Parkinson's disease according to the present invention.
Figure 3 is a process diagram for transmitting the measured value linked to the wired / wireless and Parkinson's disease diagnostic measuring apparatus according to the present invention.

상기한 목적을 달성하기 위해 하기와 같은 상세한 설명 및 도면을 통해 상세히 설명한다.
In order to achieve the above object will be described in detail through the following detailed description and drawings.

본 발명의 구성에 있어 도 1, 도 2 및 도 3에 나타낸 바와 같이 파킨슨 질환의 환자의 손에 쥘 수 있도록 환봉형의 본체(200)와, 상기 본체(200) 내부의 하부에 손 떨림을 측정하는 자이로센서부(300)와, 상기 본체(200) 내부의 중간부에 손의 이동속도를 측정하는 가속도 센서부(400)와, 상기 본체(200) 외주면에 상기 본체(200)를 쥐고 있는 동안 압력을 측정하는 복수개의 압력센서부(500)와, 상기 자이로센서부(300), 가속도센서부(400) 및 압력센서부(500)의 각각에 연결되어 신호를 전달하도록 본체(200) 내부를 통해 외부로 인가되는 유도선(600)으로 구성되는 파킨슨 질환 진단용 측정장치(100)를 제공한다.1, 2 and 3 in the configuration of the present invention to measure the shake in the round bar-shaped main body 200 and the lower portion of the inside of the main body 200 so as to be held in the hands of patients with Parkinson's disease While holding the main body 200 on the gyro sensor unit 300, the acceleration sensor unit 400 for measuring the movement speed of the hand in the middle portion of the inside of the main body 200, and the outer peripheral surface of the main body 200 The inside of the main body 200 is connected to each of the plurality of pressure sensor units 500 for measuring pressure, the gyro sensor unit 300, the acceleration sensor unit 400, and the pressure sensor unit 500 to transmit a signal. It provides a measurement device 100 for diagnosing Parkinson's disease consisting of a guide line 600 applied to the outside through.

먼저, 상기 자이로센서, 가속도센서 및 압력센서는 통상적으로 생산 또는 유통되는 것을 사용할 수 있으며, 별도로 맞춤형 센서들을 제작하여 사용할 수 있음을 밝힌다.First, the gyro sensor, the acceleration sensor and the pressure sensor can be used that is usually produced or distributed, and reveals that it can be used to make custom sensors separately.

도 1과 도 2에 나타낸 바와 같이 상기 본체(200)의 내부 하부에 구비된 자이로센서부(300)는 환자가 손에 본체(200)를 쥐고 일정시간 측정하여 환자의 손 떨림 횟수를 확인하기 위해 사용되는 자리로센서부(300)를 제공한다.As shown in FIGS. 1 and 2, the gyro sensor unit 300 provided in the lower portion of the main body 200 measures a predetermined time while the patient holds the main body 200 in the hand to check the number of hand shaking of the patient. It provides a sensor unit 300 to the seat used.

이에, 치료과정중에 환자의 손떨림 횟수를 측정하여 차료에 경과 또는 결과를 확인할 수 있도록 주기적인 데이터를 수집하여 치료에 대한 결과를 측정할 수 있게 된다.Thus, by measuring the number of shaking hands of the patient during the treatment process it is possible to collect the periodic data to determine the progress or results in the vehicle to measure the results for the treatment.

도 2에 나타낸 바와 같이 상기 본체(200)의 내부 중간부에 가속도센서부(400)를 구비함으로서, 환자가 본체(200)를 쥐고 있는 팔을 일정거리로 이동시켜 환자의 팔의 이동 속도를 확인하여 측정된 데이터를 통해 치료의 경과를 살필 수 있도록 제공된다.As shown in FIG. 2, the acceleration sensor unit 400 is provided in the inner middle portion of the main body 200 to confirm the moving speed of the arm of the patient by moving the arm holding the main body 200 to a certain distance. The measured data is then used to monitor the progress of the treatment.

그리고, 상기 본체(200)의 외주면에 복수개의 압력센서부(500)를 구비하여 환자의 손이 쥐고 있는 본체(200)를 가압함으로서 압력 데이터를 통해 회복과정을 측정할 수 있도록 제공된다.In addition, the pressure sensor unit 500 is provided on the outer circumferential surface of the main body 200 to pressurize the main body 200 held by the hand of the patient, thereby providing a recovery process through the pressure data.

이러한, 상기 자이로센서부(300), 가속도센서부(400) 및 압력센서부(500)를 통해 측정된 데이터를 통합하여 치료과정 중에 환자의 회복과정과 회복속도를 파악함으로써 환자에 적합한 치료과정을 선택하여 치료할 수 있도록 중요한 매개체로 사용되어 제공된다.
By integrating the data measured through the gyro sensor unit 300, the acceleration sensor unit 400 and the pressure sensor unit 500 to determine the treatment process and recovery rate of the patient during the treatment process to obtain a treatment process suitable for the patient. It is used as an important medium for selection and treatment.

한편, 도 3에 나타낸 바와 같이 상기 자이로센서부(300), 가속도센서부(400) 및 압력센서부(500)의 각각에 연결되어 신호를 유도선(600)을 통해 제어매체(700)인 컴퓨터 또는 스마트폰 중 택일하여 유/무선으로 전달되도록 하는 파킨슨 질환 진단용 측정장치를 제공한다.Meanwhile, as shown in FIG. 3, a computer connected to each of the gyro sensor unit 300, the acceleration sensor unit 400, and the pressure sensor unit 500 transmits a signal to the control medium 700 through the induction line 600. Alternatively, the present invention provides a measuring device for diagnosing Parkinson's disease to be delivered by wire / wireless by selecting one of the smartphones.

도 3의 (A)와 (B)에 나타낸 바와 같이 상기 저장매체(700)는 컴퓨터 또는 스마트폰에 유/무선을 통하여 측정 데이터값의 신호를 유도선(600)에 의해 전달하도록 하는 것으로 무선은 파킨슨 질환 진단용 측정장치(100)와 연계된 데이터전달기기(모뎀)를 통해 컴퓨터 또는 스마트폰에 실시간 전달 되도록 하고, 유선일 경우 직접 유도선이 컴퓨터에 연결되어 데이터값을 전달하도록 함에 있다.
As shown in (A) and (B) of FIG. 3, the storage medium 700 transmits a signal of measured data value to the computer or smartphone through the wire / wire by the induction line 600. Through a data transmission device (modem) associated with the Parkinson's disease diagnosis measuring device 100 to be delivered in real time to a computer or a smart phone, in the case of a wired direct wire is connected to the computer to deliver the data value.

상기 실시예를 통하여 설명한 바와 같이 파킨슨 질환 진단용 측정장치는 다양하게 설계 변경하여 제작할 수 있는 것으로 상시 실시예를 통하여 그 원리를 본 발명의 구성으로 한정하여 제작하되 그 원리를 통한 기구에 있어서는 통상의 지식을 가진 자가 설계변경으로 용이하게 제작할 수 있다는 것을 밝힌다.As described through the above embodiments, the Parkinson's disease diagnosis measuring apparatus can be variously changed in design and manufactured by limiting the principle to the configuration of the present invention through the constant embodiment. It can be easily manufactured by anyone with a design change.

파킨슨 질환 진단용 측정장치 : 100, 본체 : 200, 자이로센서부 : 300, 가속도센서부: 400, 압력센서부 : 500, 유도선 : 600, 제어매체 : 700Parkinson's disease diagnosis device: 100, main body: 200, gyro sensor unit: 300, acceleration sensor unit: 400, pressure sensor unit: 500, guide line: 600, control medium: 700

Claims (2)

파킨슨 질환의 환자의 손에 쥘 수 있도록 환봉형의 본체(200)와;, 상기 본체(200) 내부의 하부에 설치되는 자이로센서부(300)와;, 상기 본체(200) 내부의 중간부에 설치되는 가속도 센서부(400)와;, 상기 본체(200) 외주면에 상기 본체(200)를 쥐고 있는 동안 압력을 측정하는 복수개의 압력센서부(500)와;, 상기 자이로센서부(300), 가속도센서부(400) 및 압력센서부(500)의 각각에 연결되어 신호를 전달하도록 본체(200) 내부를 통해 외부로 인가되는 유도선(600);으로 이루어지는 것을 특징으로 하는 파킨슨 질환 진단용 측정장치에 있어서,
상기 환봉형 본체(200)의 내부에 설치된 자이로센서부(300)는 파킨슨 질환의 환자가 환봉형 본체(200)를 손에 쥐어 손 떨림 횟수를 측정하는 것으로 한정하며,
상기 가속도 센서부(400)는 파킨슨 질환의 환자가 환봉형 본체(200)를 손에 쥐어 손 떨림 속도를 측정하는 것으로 한정하는 것을 특징으로 하는 파킨슨 질환 진단용 측정장치.A round bar-shaped main body 200 to be placed in the hand of a patient with Parkinson's disease, a gyro sensor unit 300 installed below the main body 200, and an intermediate portion inside the main body 200. An acceleration sensor unit 400 to be installed; a plurality of pressure sensor units 500 for measuring pressure while holding the main body 200 on an outer circumferential surface of the main body 200; and the gyro sensor unit 300; Parkinson's disease diagnosis measuring device, characterized in that consisting of; the induction line 600 is connected to each of the acceleration sensor unit 400 and the pressure sensor unit 500 is applied to the outside through the body 200 to transmit a signal; To
The gyro sensor unit 300 installed inside the annular body 200 is limited to measuring the number of hand shaking by a patient with Parkinson's disease by holding the annular body 200 in a hand.
The acceleration sensor unit 400 is a Parkinson's disease diagnosis measuring device, characterized in that the patient with Parkinson's disease to hold the round bar-shaped body 200 to measure the hand shaking speed. 삭제delete
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GB2575524A (en) * 2018-04-19 2020-01-15 Univ Coventry Vibration dose measurement apparatus
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WO2014084441A1 (en) * 2012-11-30 2014-06-05 경희대학교 산학협력단 Apparatus and method for analyzing patient using acceleration sensor
GB2575524A (en) * 2018-04-19 2020-01-15 Univ Coventry Vibration dose measurement apparatus
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