KR100981523B1 - Cosmetic composition for treatment acne - Google Patents

Abstract

PURPOSE: A cosmetic composition with an effect for treating acne is provided to ensure antibacterial effect to Propionibacterium acne without side effects. CONSTITUTION: A method for producing a cosmetic composition for treating acne comprises: a step of pulverizing 1kg of dried Prunus japonica; a step of immersing the pulverized Prunus japonica in an extraction solvent for 7 days; a step of removing upper solid and decompressing to obtain 20-50g of concentrate; a step of adding the concentrate to the cosmetic composition in a weight% of 0.01-30. The cosmetic composition is used in the form of astringent, skin softener, lotion, essence, foundation, or soap.

Description

Cosmetic composition having an effective effect on acne {Cosmetic composition for treatment acne}

The present invention relates to a cosmetic composition having an effective effect on acne, and more particularly to a cosmetic composition having an effective effect on acne composed of natural products having antibacterial effect on propionibacterium acne bacteria and no side effects on the skin among the etiology of acne development. It relates to a composition.

In general, the pathological causes of acne are known in many ways.

The first is the formation of pores that have become a proliferative environment for acne bacteria due to hyperkeratosis and sebum increase caused by excessive secretion of male hormones.

Second, propionibacterium acne bacteria, known as excess bacteria, are known as acne-causing bacteria, and the sebum composition changes as the sebum composition changes, causing chemokines (chemokine) to occur. It is known to cause inflammation by stimulating the production of various inflammatory cytokines (cytokine).

Anti-androgens, steroid-based anti-inflammatory agents, antibiotics such as erythromycin, benzoyl peroxide, and the like are currently used in response to the acne etiology of acne, and salicylic acid is also mainly used as a keratin dissolving agent.

However, the raw materials such as antibiotics or benzoyl phosphoxide are excellent in efficacy and can be used only for medicines, and also have many side effects, and therefore have a short-term use only locally.

In addition, acne outbreaks occur due to physiological phenomena, so long-term improvement in the treatment, but the recurrence rate when the treatment is interrupted and has a characteristic that sometimes disappears due to changes in age or physiological environment.

As such acne treatment requires long-term treatment, there is no skin side effect and need ingredients and preparations that are continuously effective. Therefore, a natural extract having an antimicrobial effect against acne causing bacteria from natural products has been developed and used for external skin preparations.

Thus, a conventional patent has been disclosed that provides effective efficacy for acne using natural extracts. Patent No. 10-0610951 used the antimicrobial effect on the propionibacterium acne of kill extracts, and Patent No. 10-0100963 In the case of the tri-oil and the antimicrobial effect of the ilga acid DP-300, Patent No. 10-0092324 has a case using the antibacterial effect of myrrh, gall bladder, ginkgo leaf.

However, all of these patents are intended to provide an effective composition for acne using antimicrobial effects on propionibacterium acne bacteria of natural products themselves, but it is insufficient to identify which components in these natural products exhibit antibacterial effects and produce antibacterial effects. And new side effects occur due to irritation, etc. There was a disadvantage in not properly exerting the treatment effect of acne.

The present invention is to solve the above problems and to provide an effective skin external preparation for acne treatment by the extract of San cherry in order to provide an effective cosmetic composition for acne.

In addition, the present invention was to develop a natural product having an antimicrobial effect on propionibacterium acne bacteria among the etiology of acne development, this extract has no side effects on the skin, and provides a skin external preparation clinically confirmed to improve acne have.

The present invention provides a skin external preparation effective in acne treatment by inhibiting the growth of Propionibacterium acne by the extract of the skin by the skin cosmetic composition containing Prunus japonica extract, but in the present invention Is contained 0.01-30% by weight of the total weight of the cosmetics, characterized by a cosmetic composition that has an effective antibacterial activity with excellent antibacterial activity by fatty acids such as myristoleic acid and palmitoleic acid contained in the extract It is done.

Since the cosmetic composition having an effective effect on acne of the present invention exhibits an effective effect on acne treatment, it solves the skin troubles of modern people who suffer from acne and focus on appearance through the development of skin external preparations of appropriate formulations suitable for skin. It has the effect of generating technological development and added value.

The present invention is to select a natural product having an antimicrobial effect on Propionibacterium acne bacteria in order to provide a cosmetic composition effective for acne and through the chromatographic separation analysis technology of the active ingredient in the natural product Myristoleic acid, palmi Teleic acid and arachidonic acid component has been shown to have excellent antimicrobial effect on the acne causing bacteria, developed a variety of products using this extract and completed the present invention by clinically tested efficacy.

The present invention was to develop a natural product having an antimicrobial effect on propionibacterium acne bacteria among the etiology of acne development, this extract has no side effects on the skin, and to develop a skin external preparation clinically confirmed to improve acne.

The skin cosmetic composition of the present invention contains a Prunus japonica extract to inhibit the growth of Propionibacterium acne by the San-Phi extract provides an effective skin external preparation for acne treatment.

In the acne cosmetic composition of the present invention, it is preferable to contain 0.01-30% by weight of Sanya extract based on the total weight of the composition, which is less effective in treatment when the Sanya extract is 0.01% by weight or less, which is more than 30% by weight. This is because problems such as skin troubles occur.

The extraction solvent of the San cherry extract is selected from water, ethanol, methanol, glycerol, propylene glycol, ethylene glycol, 1,3-butylene glycol, isopropyl alcohol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether and chloroform It consists of an extract obtained after extraction with one or more solvents and removal of the solvents.

The Sanpri extract contains myristoleic acid, palmitoleic acid as an active ingredient.

In addition, the cosmetic composition includes a cosmetic composition consisting of astringent makeup, softening makeup, lotion, essence, foundation, soap and the like.

Hereinafter, described in detail with reference to a preferred embodiment of the present invention. In describing the present invention, when it is determined that the detailed description of the related known function may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted.

The present invention for the development of a natural product having an antimicrobial effect on propionibacterium acne from various natural products, the antimicrobial effect is effective by using the zone of inhibition (MIC) and minimum inhibitory concentration (MIC) In order to determine which components in the extract contribute to the effect, the active ingredient was separated, the structure thereof was revealed, and the present invention was solved through skin irritation tests and clinical trials on the external preparations containing the extract.

[Selection of Antibacterial Natural Extracts]

About 200 domestic native plants were purchased from herbal materials, etc., and then pulverized into 1 kg each in a 20L plastic barrel, and then immersed in 70% ethanol solution for 7 days. After 7 days, the upper solid was filtered off and the filtrate was concentrated under reduced pressure to obtain a concentrate between 20-50 g.

In order to measure the antimicrobial effect on the obtained concentrate, four strains were cultured and 1 ml each of the cultured culture solution was evenly applied to agar plates prepared in advance. Filter paper disks (diameter 8 mm) prepared on the strain-coated plate was placed in the center and a natural product sample was added at a concentration of 500 ug / disc.

The plate prepared by the above method was incubated for 2 days and then measured by measuring the inhibition ring with a ruler. The zone of inhibition (mm) was calculated by subtracting the diameter of the transparent zone (mm) by 2 and subtracting 8mm, the diameter of the paper disc. As a result of the test, the extract which showed the best antimicrobial effect was San cherry extract, and showed similar results with benzoyl peroxide.

[Table 1] Antibacterial effect of San cherry extract

division Inhibitory ring (mm) Remarks Wild Cherry Extract 15 Upper limb extract - Gujeolcho Extract One Injin mugwort extract 3 Benzoyl peroxide 16 Control

[Identification of Antimicrobial Components in Sanya Extract]

In order to identify the antimicrobial active ingredients in selected Sanya extract, 10 active ingredients were separated and analyzed by chromatographic method and instrumental analysis.

[Table 2] Antibacterial Effect of Isolated Components in Sanya Extract

division Inhibitory ring (200 ug, mm) Minimum inhibitory concentration (ug / L) Remarks Caproic Acid - - Caprylic Acid - - Capric acid - - Mystic Acid - - Palmitic Acid - - Stearic acid - - Arachidic Acid - - Mylestoleic Acid 16 32 Palmitoleic Acid 14 32 Oleic Acid - - Tetracycline 25 2 Control, antibiotic

As shown in Table 2, the San-Jin extract contains the myristoleic acid and palmitoleic acid components having antimicrobial effects similar to that of the antibiotic tetracycline. .

Production Example

Example 1 Convergence Cosmetics for Effect Measurement

ingredient Example (Content) Comparative example (contents%) 1,3-butylene glycol 4.0 4.0 ethanol 20.0 20.0 Salicylic acid 0.5 0.5 Polyoxyethylene lauryl ether 1.0 1.0 antiseptic Quantity Quantity Spices Quantity Quantity Wild Cherry Extract 1.0 - Purified water Remainder Remainder

<Acne treatment effect>

division Excellent effect Normal effect no effect Worse system Example 1 3 5 2 - 10 people Comparative example - - 8 2 10 people

As shown in the table above, the astringent cosmetics containing San-Pharm extract showed an acne treatment effect in more than 80% of patients when applied to acne patients, and the treatment effect was confirmed to be superior to that of the comparative example.

Example 2 Flexible Cosmetics

ingredient content(%) 1,3-butylene glycol 4.0 Oleyl alcohol 0.1 Polyoxyethylene lauryl ether 0.5 Monolauric acid polyoxyethylene sorbitan 1.5 ethanol 8.0 antiseptic Quantity Spices Quantity Wild Cherry Extract 0.5 Purified water Remainder

Example 3 Lotion

ingredient content(%) 1,3-butylene glycol 8.0 Stearic acid 0.5 Squalane 2.5 Liquid paraffin 6.0 Monooleic acid polyoxyethylene sorbitan 1.5 Trientanolamine 0.8 Antioxidant Quantity antiseptic Quantity Spices Quantity Wild Cherry Extract 1.0 Purified water Remainder

Example 4 Cream

ingredient content(%) Squalane 5.0 Stearic acid 8.0 vaseline 2.0 Self-emulsifying glycerin monostearate 2.5 Monostearic acid polyoxyethylene sorbitan 1.5 Propylene glycol 8.0 Spices Quantity antiseptic Quantity Liquid paraffin 3.0 Glyceryl Stearate 2.0 Wild Cherry Extract 1.0 Purified water Remainder

Example 5 Essence

ingredient content(%) 1,3-butylene glycol 9.0 Hyaluronic acid 8.0 PEG-40 Hydrogenate Castor Oil 0.25 Squalane 0.2 Water Soluble Collagen 0.6 Carboxy Vinyl Polymer 0.25 Glycolic acid 0.1 antiseptic Quantity Spices Quantity Wild Cherry Extract 2.0 Purified water Remainder

Example 6 Foundation

ingredient content(%) lanolin 2.0 glycerin 4.0 Stearic acid 3.0 Isopyrophyll myristic acid 5.5 Bentonite 0.5 Titanium Oxide 8.0 Talc 4.0 Pigment Quantity antiseptic Quantity Spices Quantity Wild Cherry Extract 0.5 Purified water Remainder

Example 7 Soap

ingredient content(%) glycerin 1.0 Titanium dioxide 0.5 Olive oil 1.0 Spices Quantity Pigment Quantity Wild Cherry Extract 1.0 Soap Chip Remainder

<Skin irritation test result>

division result Judgment Convergence Cosmetics 0.5 Non-irritating Flexible Cosmetics 0.3 Non-irritating Lotion 0.0 Non-irritating cream 0.0 Non-irritating essence 0.0 Non-irritating foundation 0.3 Non-irritating Positive control group 5.0 SLS 1% solution Negative Control 0.0 Purified water

* Test method: Modified Patch teat, Finn chamber use, 30 people, 2 days attachment

As described above, the present invention provides an important technique for the development of the external preparation for skin having an effective effect in the treatment of acne.

Figure 1 is a photograph of the inhibition ring measurement results for the extract of Table 1 containing Sanya extract.

Claims (4)

Grinding 1 kg of dried corn, Immersing the ground product in an extraction solvent for 7 days, Concentrating under reduced pressure after removing the upper solid to obtain 20 to 50 g of the concentrate, To obtain a cosmetic composition by the step of containing the concentrate in an amount of 0.01 to 30% by weight relative to the total weight of the cosmetic composition, The cosmetic composition is made of any one of astringent makeup, flexible makeup, lotion, essence, foundation, soap, Extraction solvent of the concentrate is water, ethanol, methanol, glycerol, propylene glycol, ethylene glycol, 1,3-butylene glycol, isopropyl alcohol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether, chloroform Consists of more than one solvent, The concentrate is a myristoleic acid, acne cosmetic composition, characterized in that it contains palmitoleic acid as an active ingredient. delete delete delete

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