KR100969269B1 - Cosmetic compositions for preventing hair loss and stimulating hair growth comprising saw palmetto extract, althea rosea root extract, portulaca oleracea extract, walnut extract - Google Patents

Abstract

The present invention relates to a composition of cosmetics having a hair loss prevention and wool promoting effect containing the saw palmetto, Takyu Kyun, guchi, walnut extract using the ultrasonic extraction method. The present invention was confirmed that the excellent natural hair loss and hair growth effect through the mouse test and simple clinical trial by extracting the active ingredient having the same effect compared to the conventional hot water extraction method without damage by using the ultrasonic method when extracting natural products . The present invention can develop a cosmetic having a more effective hair loss prevention and hair growth effect using the ultrasonic extract method. The invention containing this natural extract can be used more safely by applying it as a cosmetic and can be easily used as a shampoo or tonic, so that it is possible to commercialize excellent effects and safer hair growth and hair loss prevention products. It can be a great help to open up the market.

Saw Palmetto Extract, Tectonic Root Extract, Portulaca Extract, Walnut Extract, Ultrasonic Extraction, Hair Loss Prevention, Hair Growth Effect

Description

Cosmetic compositions for preventing hair loss and promoting wool including saw palmetto extract, kokkeuksu extract, guchi extract, and walnut extract {alcoa composition for preventing hair loss and stimulating hair growth comprising saw palmetto extract, althea rosea root extract, portulaca oleracea extract, walnut extract}

The present invention relates to a composition having a hair loss prevention and wool effect, and more specifically, as an active ingredient, which contains natural products extracted through ultrasonic extraction instead of general solvent extraction, and can be used safely without side effects, and promotes blood circulation of the scalp. Rather, it relates to a composition that improves the prevention of hair loss and the promotion of wool by the action of anti-inflammatory action of moisturizing muscles, and prevention of parallel problems during hair loss through moisturizing action of machi.

In order to meet the demand for the development of natural products that are excellent in effectiveness and safe for humans in a situation where there is an increase in stress and hair loss population due to environmental genetic factors. The hair is dropped out through the growth phase, the stage in which the hair grows, the degenerative phase in which the hair grows stagnant, and the rest period before the hair is dropped out. Hair loss is basically the action of 5-alpha-reductase, which is distributed around the hair follicles, and testosterone, a type of male hormone, changes to DHT, which is known to cause hair loss. The activated DHT binds to the androgen receptor, shortens the growth phase of the hair, shrinks the size of the hair follicles, decreases the hair growth stage, increases the number of resting hairs, and eventually causes hair loss. Existing developed, produced and marketed formulations include minoxidil formulations as the main ingredients and synthetic formulations, and propecia as the edible formulations. These ingredients have side effects such as the induction of seborrheic dermatitis during long-term application of minoxidil preparations, and a decrease in sexual function when taking propecia, and thus have fundamental problems that require a doctor's prescription. In order to solve this problem, agents having a hair loss prevention and hair growth effect that have no side effects even when applied for a long time using a natural extract have been studied. Conventional methods for extracting natural extracts include extraction with a solvent such as ethanol and extraction with hot water. These methods require a long extraction time and the destruction of the active ingredient during extraction and the efficiency of extraction decreases. I have a problem.

Therefore, the present invention, in order to solve the above problems by reducing the extraction time using ultrasonic waves and extracting the active ingredient without damage as a result of trying to obtain a more effective cosmetics, mouse test and liver clinical results superior effect than the conventional extraction method A composition with was obtained.

The present invention is to provide a cosmetic composition containing an extract using ultrasonic waves having these characteristics.

In order to achieve the above object, the present invention includes a saw palmetto extract, kokkukeun extract, guchi extract, walnut extract, but provides a composition having a hair loss prevention and wool effect containing the extract extracted by the ultrasonic extraction method.

Hair loss prevention and wool promotion cosmetic composition containing a saw palmetto extract, Takyu muscle extract, gut extract and walnut extract according to the present invention 200 to 400 parts by weight, Takyu muscle extract 200 based on 100 parts by weight of walnut extract To 400 parts by weight, including the portray extract 200 to 400 parts by weight, characterized in that the extract is extracted by ultrasonic extraction.

In particular, the cosmetic composition for hair loss prevention and wool promotion containing saw palmetto extract, Takyu muscle extract, March extract and walnut extract according to the present invention based on 100 parts by weight of walnut extract, 300 parts by weight of saw palm extract, 300 kg Part, made of including 300 parts by weight gusset extract, characterized in that the extract is extracted by ultrasonic extraction.

Therefore, according to the present invention, using the composition of the saw palmetto extract, Takgyu muscle extract, Machihyeon extract and walnut extract using the ultrasonic extract helps to promote blood circulation, cleanliness, scalp inflammation of the scalp, healthy and clean scalp Condition and hair can be repaired. In addition, the composition can be used as a natural extract without worrying of side effects can be used as a substitute for drugs that require a doctor's prescription or are concerned about side effects.

Hair loss prevention and wool promotion cosmetic composition containing saw palmetto extract, Takyu muscle extract, March extract and walnut extract according to the present invention include saw palmetto extract, Takyu muscle extract, March extract, walnut extract, using ultrasonic extraction Characterized by consisting of the extracted extract.

Hair loss prevention and wool promotion cosmetic composition containing a saw palmetto extract, Takyu muscle extract, gut extract and walnut extract according to the present invention 200 to 400 parts by weight, Takyu muscle extract 200 based on 100 parts by weight of walnut extract To 400 parts by weight, including the portray extract 200 to 400 parts by weight, characterized in that the extract is extracted by ultrasonic extraction.

In particular, the cosmetic composition for hair loss prevention and wool promotion containing saw palmetto extract, Takyu muscle extract, March extract and walnut extract according to the present invention based on 100 parts by weight of walnut extract, 300 parts by weight of saw palm extract, 300 kg Part, made of including 300 parts by weight gusset extract, characterized in that the extract is extracted by ultrasonic extraction.

Saw palmetto extract from the above not only promotes blood circulation to supply the nutrients necessary for hair growth to increase hair growth, but also inhibits the activity of the 5-alpha-reductase, thereby reducing the activity of DHT to reduce hair loss. It functions to suppress. If the saw palmetto extract is included in an amount of less than 200 parts by weight, there may be a problem that the hair loss inhibitory effect is not sufficient, on the contrary, if it exceeds 400 parts by weight, there may be a problem that can cause drying by inhibiting excessive DHT activity Can be.

Tak Kyu Keun extract and Machi Hyun extract help to soothe sensitive scalp and inhibit dandruff and clogged hair follicles to help the birth of hair and to prevent fallout. When each of the extracts of Chokkeuk-geun or Macchi-hyun extract is contained in an amount of less than 200 parts by weight, there may be a problem that the effect on the scalp soothing or hair follicle clogging is not sufficient, if the amount exceeds 400 parts by weight, causing precipitation of the product There may be a problem that the formulation becomes unstable.

Walnut extract helps to promote blood circulation in the scalp, turning it into a shiny, elastic hair. If the walnut extract is included in an amount of less than 200 parts by weight, there may be a problem that the effect of promoting scalp blood circulation is not sufficient, on the contrary, if it exceeds 400 parts by weight, the stability of the formulation is caused by causing severe discoloration on the product There may be a problem that goes bad.

The saw palmetto extract, chokeun muscle extract, guchi extract or walnut extract may be obtained by ultrasonic extraction. That is, the extracts are obtained by dispersing 25 parts by weight of powder each of saw palmetto, coccyx, machi and walnut in 75 parts by weight of water and applying ultrasonic waves at 45OO Pa for 20 minutes, followed by filtration. In general, ultrasound refers to sound waves having a higher frequency (> 16 Hz) than the human audible frequency range of 16 Hz to 16 Hz. In the geology field, the ultrasonic wave uses the pulse and ringing characteristics. It is used for exploration and underwater exploration of underground mineral resources. It is widely used as a tool for diagnosing the disease state of the body in the medical field, and as a tool for easily dispersing pigments and solids in the industry, and for washing various equipment. It is usefully used as a means. When the ultrasonic wave is generated, the cavitation (cavitation) generated when the ultrasonic wave passes through the medium affects the chemical reaction, thereby promoting the chemical reaction. Therefore, such an ultrasonic wave may be usefully used as various technologies, and particularly, when the ultrasonic application technology is applied to the extraction field, the treatment effect may be very high. Ultrasonic waves have excellent penetration and are widely used early in the industrial, medical, and cleaning fields. The use of ultrasonic waves can be classified into dynamic, instrumental, and communication applications. Among them, ultrasonic extraction, which is a dynamic application, becomes a small wave due to the powerful ultrasonic waves applied in a liquid, resulting in compression force (static pressure) and expansion force (negative pressure). It will appear repeatedly. When ultrasonic waves are used in various chemical reactions, the energy source that improves the reactivity is cavitation, and cavitation occurs in three stages: nucleation, growth of bubbles, and explosive bursting of sufficiently grown bubbles. When irradiated with a powerful ultrasonic wave in a liquid medium, these nuclei vibrate, resulting in shorter average distances between molecules in periods of high molecular density and high density, and lengthy periods of sparse states with low molecular density. Ultrasonic waves are one of the methods for studying the structure and properties of solids, liquids, and gases, and have been used to study the dependence of the elastic modulus of solids and the temperature, pressure, and frequency of sound velocity in solids. Has been used to specify the thickness and defects of materials without permanent deformation. Ultrasonic research has begun since the 1980s, which has achieved good efficiency for fast reaction times in grinding, mixing and extraction processes. When ultrasonic energy is used for extraction, very large energy is generated by cavitation caused by ultrasonic vibration. In addition, due to the high local temperature, the kinetic energy of the reactant particles located in the surroundings is increased to obtain sufficient energy for the reaction, and the impact effect of the ultrasonic energy induces high pressure to increase the mixing effect. The ultrasonic extraction is completed in a very short time compared to the solvent extraction and the extraction time is reduced to about 10 times or more than the supercritical fluid extraction process. In the case of the ultrasonic extraction, a study has been reported that the internal tissue is destroyed by the high pressure caused by the co-effect of the ultrasonic wave, and thus the fat moving distance is shortened and the diffusion occurs easily. The ultrasonic extractor used for the ultrasonic extraction of the components in the present invention is known enough to be purchased and used commercially supplied by leading manufacturers at home and abroad, for example, the product name Sony Medi, but the present invention is not limited thereto.

The composition of the present invention having the above-described composition is also possible in various formulations such as shampoo, rinse, tonic, essence and the like.

That is, it can be formulated into cosmetics, including the cosmetic base as the amount and the amount of 1 to 50% by weight of the hair loss prevention and wool promotion composition containing saw palmetto extract, Takyu muscle extract, guchi extract and walnut extract as described above. . The cosmetic bases are to be understood as known in the industry. That is, the cosmetic base may be any one cosmetic selected from shampoos, rinses, treatments, tonics, but the present invention is not limited thereto. The above shampoos, rinses, treatments, tonics are all to be easily understood by those of ordinary skill in the industry, and also by the leading manufacturers at home and abroad at the time of the present application It may be the same as or similar to commercially provided cosmetics, ie shampoos, rinses, treatments, tonics.

Hereinafter, preferred embodiments and comparative examples of the present invention will be described.

The following examples are intended to illustrate the invention and should not be understood as limiting the scope of the invention.

Example  One

Based on 100 parts by weight of the walnut extract obtained by the ultrasonic extraction method, here, 300 parts by weight of the saw palm extract, 300 parts by weight of the root muscle extract and 300 parts by weight of the gut extract, respectively, prevent hair loss and wool according to the present invention. A promotion composition was prepared. In the above ultrasonic extraction was used Sony Medi brand name of Sony Medi Corporation. In the present composition, the content of solids was 25%, and the content of water was 75%.

Comparative example  One

Based on 100 parts by weight of walnut extract extracted and filtered by hot water extraction, which was extracted for 1 hour with water at 90 ° C. to verify the effect according to the extraction method, 300 parts by weight of the saw palm extract obtained by the same hot water extraction as well To prepare a composition for preventing hair loss and promoting wool as a control by mixing 300 parts by weight of the extract, and 300 parts by weight of gut extract. In this composition the content of solids was 25% and the content of water was 75%.

Experimental Example  One

Evaluation of Wool Functionality in Complex Compositions (Mouse)

A hair score test using a mouse was performed to compare the validation of Example 1 and Comparative Example 1. Animals used in the test were purchased from 5 weeks-old SPF (specific pathogen-free) C57 / BL6 mice with an average body weight of about 23 g from the central laboratory animals, and allowed to acclimate for about 1 week. Humidity 50 ± 10%, exhaust 10-12 times, fluorescent light intensity 12 hours cycle, illuminance 150-160 Lux (Lux) was tested in four animals in the cage for the experimental animals for the entire test period.

In order to evaluate the gross findings of the skin, the hair growth site was photographed using a digital camera to observe the characteristics related to hair growth in the skin on the 18th day of the test.

In order to observe the histological changes of hair follicles in the skin, the hair growth site of the dorsal skin was cut in parallel to the vertebral line and fixed with 4% paraformaldehyde solution. After fixation, frozen sections were prepared by the general method, and 7 µm sections were prepared and subjected to H & E staining (Hematoxylin-eosin staining) to observe tissue changes.

After the application of the composition of Example 1 and the composition of Comparative Example 1 divided into the untreated group, the composition treated group of Example 1 and the composition treated group of Comparative Example 1 as a control group, and visually observed on the 18th day In the untreated group, the control group showed hair growth in very small portions and gray spots in the dorsal skin, and no visible hair growth was observed. In the case of complete hair removal on the entire depilated skin area, no single example was observed, and the hair growth rate was about 2 to 3% of the depilated skin area as a whole (FIG. 1).

On the other hand, in the group in which Example 1 was applied to the skin, almost all hair growth was observed in all four of the depilated skin areas (FIG. 2).

On the contrary, in the group coated with Preparation Example 2 on the skin, 2/4 cases of hair growth were observed on the entire back, and the hair growth phenomenon of about 50% was observed as a whole (FIG. 3).

Microscopic observations showed that the number of hair follicles in the dermal layer was less than normal in the untreated group as a control (FIG. 4).

In the group coated with Example 1 on the skin, a large number of hair follicles were observed when compared to the control group and the Comparative Example 1 applied to the skin, and the hair shaft in the hair follicles was most observed (FIG. 5). ).

In the group coated with Comparative Example 1 on the skin, the number of hair follicles was observed in the same visual field as compared with the control group, but fewer hair follicles were observed compared to Example 1 (FIG. 6).

In summary, the results of Example 1 extracted with ultrasonic waves were superior to the general hydrothermal extraction method.

Experimental Example  2

Functional Evaluation of Ultrasonic Extraction Composition (Simple Clinical Experiment Results)

In order to confirm the effect through a real person, a small clinical trial was conducted by selecting female and male alopecia patients through a basic formulation that can be commercialized with Example 1 and Comparative Example 1. Subjects were 30 adult males and females in their 20s and 70s (male: 23, female: 7).

The experiment was conducted for 3 months and the effect was confirmed every 15 days. As a method, a daily dose (120 ml) was prescribed per patient per month, and the progress of treatment was measured every 15 days, and the measurement was performed by visual inspection, and the results are shown in Table 1 (Example). 1) and Table 2 (Comparative Example 1).

division 15th 30 days 45 days 60 days 75 days 90 days Reduced hair loss 53% 75% 90% 90% 100% 100% Down 0% 24% 60% 83% 93% 100% Down and thickening of existing hair 0% 0% 8% 13% 50% 96% New hair starts to appear 0% 0% 0% 0% 10% 56%

division 15th 30 days 45 days 60 days 75 days 90 days Reduced hair loss 13% 35% 46% 46% 53% 53% Down 0% 13% 16% 23% 23% 52% Down and thickening of existing hair 0% 0% 0% 5% 35% 35% New hair starts to appear 0% 0% 0% 0% 7% 10%

As a result of the above results, when applying the composition according to the present invention, it was confirmed that twice as much hair loss prevention effect can be obtained in the same composition as compared with the composition by the normal hot water extraction method.

The present invention can be used in the field of industry as providing a cosmetic composition for wool.

Although the present invention has been described in detail only with respect to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical scope of the present invention, and such modifications and modifications are within the scope of the appended claims.

1 is a photograph showing the mouse test results as a control.

Figure 2 is a photograph showing the mouse test results of applying the composition using the ultrasonic extraction method.

3 is a photograph showing the mouse test results of applying the composition using the hot water extraction method.

4 is a micrograph of a mouse test as a control.

Figure 5 is a micrograph of a mouse test to which the composition was applied using the ultrasonic extraction method.

Figure 6 is a micrograph of a mouse test to which the composition was applied using the hot water extraction method.

Claims (4)

Based on 100 parts by weight of walnut extract based on 200 to 400 parts by weight of Saw palmetto (Serenoa Repens) extract, 200 to 400 parts by weight of Takyu root extract, guchi extract 200 to 400 parts by weight, the extracts are extracted by ultrasonic extraction Hair loss prevention and wool promotion composition comprising a saw palmetto extract, Gokyu-Geun extract, Portulaca extract and walnut extract, characterized in that. The method of claim 1, Saw palmetto extract (Serenoa Repens) extract based on 100 parts by weight of walnut extract, consisting of 300 parts by weight of the root muscle extract, 300 parts by weight of gut extract, characterized in that the extract is extracted by ultrasonic extraction A composition for preventing hair loss and promoting wool containing palm extract, chok-geun extract, guchi extract and walnut extract. Hair loss containing Serenoa Repens extract, Cucumber root extract, Portulaca oleracea extract and Walnut extract, comprising the cosmetic base as an amount and the amount of 1 to 50% by weight of the composition of claim 1 Cosmetic composition for prevention and promotion of wool. The method of claim 3, wherein Hair loss prevention and wool promotion containing Serenoa Repens extract, Tsukyu muscle extract, Portugese extract and Walnut extract, characterized in that the cosmetic base is any one cosmetic selected from shampoo, rinse, treatment, tonics Cosmetic composition.

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