KR100914381B1 - A composition for treating striae distensae - Google Patents

Abstract

The present invention relates to a composition for treating swelling progenitors comprising glucose and a physiologically applicable solvent and having an osmolality of 120% to 350% higher than the osmolality of cells in the body due to the glucose. The composition for treating swelling lineage according to the present invention may promote the regeneration of the skin by promoting collagen production in damaged dermal tissue to treat the swelling lineage.

Collagen, osmotic pressure, swelling, stretch marks

Description

Composition for the treatment of swelling ancestors {A COMPOSITION FOR TREATING STRIAE DISTENSAE}

The present invention relates to a composition for treating swelling ancestors that can promote collagen formation to activate skin regeneration.

The skin surrounding the human body is a very elastic tissue, but if the subcutaneous body tissues, such as muscles or fats, suddenly quantitatively swell, the skin may tear without keeping up with the rate of expansion. The thighs and abdomen, such as the skin is not able to keep up with the expansion rate of subcutaneous body tissues, thin cracking or tearing symptoms called Striae Distensae or stretch marks. Dilation striation can also be caused by physiological or pathological factors that increase the adrenal cortex hormones in the body, causing the collagen and elastin fibers in the dermal layer to react sensitively, or to stop the growth rate of collagen against rapid muscle growth. . It can also appear after prolonged application of steroid hormones.

These swelling striations are different in the lesion area and occur mainly in the legs when they are caused by puberty or weight gain, and occur mainly in the lower abdomen and thighs during pregnancy, and when caused by endocrine diseases. Can occur anywhere above

As an early lesion of Peng Chang's ancestors, blue-red lines appear mainly on the upper layers of the hips, thighs, belly, back of the knees, or breasts. It looks a bit bumpy. This initial lesion area turns white over time.

Swelling is more likely to be treated early on, but after turning white, it is difficult to expect a satisfactory therapeutic effect. Conventionally, as a method for treating an initial stage of expansion swelling, there is a method of treating using a Versapulse laser, or a method of applying retinoid acid to the site of the development of swelling swelling. In addition, as a method of treating the swelling of the late stage, retinoic acid is applied for several months, and the epidermis is peeled thinly using an ultrapulse CO ₂ laser or Erbium-YAG laser. There is a method of stimulating collagen fibroblasts to promote collagen remodeling. However, the conventional swelling treatment method of the conventional swelling takes about 6 months to 1 year, it is difficult to show more than 50% improvement even if the treatment, and in some cases may cause side effects such as erythema, pigmentation.

The present inventors have tried to develop a swelling line therapy or a composition for treating swelling line with excellent treatment efficiency but no side effects or very little.

Accordingly, the present inventors have found that when injecting a swelling progenitor composition comprising glucose and a physiologically applicable solvent into damaged dermal tissue, regeneration of skin tissue can be activated to promote collagen synthesis of the dermis.

The present invention is based on this.

The present invention includes glucose and a physiologically applicable solvent, and provides a composition for treating swelling progenitors with an osmolality of 120% to 350% higher than the osmolality of cells in the body due to the glucose.

In addition, the present invention (i) glucose; (Ii) at least one vitamin selected from the group consisting of retinoids, ascorbic acid, tocopherols, chiamine, riboflavin, pyridoxine and niacin; And (iii) a composition for dermal growth comprising physiological saline or distilled water, it provides a dermal growth composition having an osmolality of 500 to 1000 mOsmole / L of the dermal growth composition.

The composition for treating swelling filigree according to the present invention may promote collagen production in damaged dermal tissue to activate the regeneration of the skin.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

The skin is generally composed of epidermis, dermis and subcutaneous fat (see FIG. 1). The lower part of the epidermis of the skin is the dermis, which is mainly composed of connective tissue collagen. The collagen may be destroyed by physical force or other factors, causing cracks on the skin, which may cause the skin to dent or crack. This abnormality is generally called Striae Distensae.

The composition for the treatment of swelling progenitor of the present invention is characterized in that the osmolality is controlled by the glucose, including glucose and a physiologically applicable solvent, to be higher than the osmolality of cells in the body. By using such a swelling composition for treatment of swelling, it is possible to stimulate and nourish the damaged skin at the same time to promote collagen formation on the damaged skin to activate skin regeneration.

For example, according to one embodiment of the present invention, by injecting a swelling line treatment composition comprising a high concentration of glucose into the damaged dermal tissue, to cause micro-inflammation, the inflammation by the self-healing mechanism acts on the skin to collagen formation By promoting the regeneration of the skin, the regeneration of the skin can be effectively treated, the wrinkles can be improved, or the dermis can be effectively expanded to the wound site.

In the present invention, glucose not only acts as a nutritional substance, but also controls osmotic pressure by adjusting the osmolality of the composition for treating the swelling progenitor of the present invention. When the glucose is included in a large amount, an inflammatory response may be induced by generating a difference in concentration between a cell site into which the composition for treating the swelling progenitor according to the present invention is injected and a peripheral cell that is not. Collagen synthesis is promoted by this inflammatory response, wherein the glucose may act as a nutrient for supplying energy necessary for the formation of collagen. The collagen formation process can be developed in a wide variety of ways, in the present invention, the glucose is applied to at least one of the collagen production mechanism serves to promote collagen production.

The amount of such glucose may be about 5 to 50 parts by weight with respect to 100 parts by weight of the composition for treating the swelling line according to an example of the present invention. If the content of glucose is less than 5 parts by weight, the osmotic shock is too fine to expect the desired effect, if the content of glucose is more than 50 parts by weight there is a risk of excessive damage to the skin due to excessive osmotic pressure.

The composition for treating swelling filigree of the present invention includes the high concentration of glucose, so that the osmolarity may be about 500 to 1000 mOsmole / L. If the osmolality of the swelling treatment composition is less than 500 mOsmole / L, osmotic pressure is unlikely to occur, and if the osmolality is more than 1000 mOsmole / L, side effects may occur such as excessive damage to skin tissue. have.

Specifically, since the osmolality of the cells in the body is about 285 to 300 mOsmole / L, the cell tissue to which the swelling treatment composition according to the present invention is injected is approximately osmolality due to the composition compared to the surrounding cell tissue that is not It becomes as high as 500-1000 mOsmole / L, and a density | concentration difference arises between both cells. Due to this concentration difference, the osmotic shock is generated in which moisture in the surrounding cell tissues having low concentration is introduced into the expanded progenitor treatment composition and moved to the cell tissue having higher concentration.

When moisture is released from the surrounding cells by the osmotic shock, the surrounding cells are killed or damaged, thereby causing blood cells such as lymphocytes, multinuclear leukocytes, monocytes, etc., which come from the blood to heal the damaged area, induce an inflammatory response. It also releases cytokines to damaged surrounding cells. Thereafter, fibroblasts are induced by the cytokine, the fibroblasts produce a substrate containing procollagen, and the resulting procollagen is cut and crosslinked to the size of the collagen molecule to form new collagen of damaged dermal tissue. Will be converted to. By promoting the formation of new collagen in the damaged dermal tissue in this way, the area, depth, color and the like of the swelling lineage can be gradually reduced to treat the swelling lineage.

In addition, physiological saline or distilled water may be used as a physiologically applicable solvent in the present invention. The physiologically applicable solvent may be about 50 to 90 parts by weight based on 100 parts by weight of the composition for treating the swelling line.

In addition, in addition to the glucose, the composition for treating the swelling progenitor of the present invention may further include various collagen generating auxiliaries for activating enzymes necessary for the formation of collagen in damaged dermal tissue or enhancing skin elasticity.

For example, the composition for treating swelling striation according to the present invention may include a retinoid as a collagen production aid. The retinoid is meant to include retinol, retinoic acid, retinal, retinyl esters and derivatives thereof. The retinoids can prevent skin aging and help promote the synthesis of collagen to eliminate wrinkles. In particular, it is possible to prevent the generation of wrinkles by reducing the production of collagenase by ultraviolet rays. Retinol, retinyl palmitate may be used as the retinoid, and preferably retinyl palmitate may be used.

The retinoid content may be about 0.01 to 1 part by weight based on 100 parts by weight of the total composition. If the content of the retinoid is too small, it is difficult to expect the effect by the retinoid, and if the content is too high, side effects such as cracking or dryness of the skin may be caused, so the content is adjusted as described above.

In addition, the composition for treating the swelling ancestry according to the present invention may include ascorbic acid as a collagen production aid. The ascorbic acid is meant to include ascorbic acid derivatives, as well as to activate the hydroxylase (enzyme required for the synthesis of collagen), inhibit the melanin production of melanocytes of the epidermis, oxidized melanin By reducing the color to brighten, it can prevent the aging of the skin. Ascorbic acid, Ascorbic acid; Esters of ascorbic acid such as ascorbyl palmitate, ascorbyl acetate, ascorbyl propionate and ascorbyl stearate; Salts of ascorbic acid, such as sodium ascorbate, calcium ascorbate, magnesium ascorbate and zinc ascorbate, and the like. It doesn't happen.

The content of ascorbic acid may be about 0.01 to 1 part by weight based on 100 parts by weight of the total composition. If the content of ascorbic acid is too small, it is difficult to expect the hydroxylase activation effect by ascorbic acid, and if the content is too high, side effects may occur, so the content is adjusted as described above.

In addition, the composition for the treatment of swelling ancestry according to the present invention may include tocopherol (Tocopherol) as a collagen production aid. The tocopherol is a meaning containing a tocopherol derivative, it may serve as an effective antioxidant that can prevent the destruction of epidermal lipids, collagen and elastin. As the tocopherol, tocopherol acetate (Tocopherol Acetate) can be used.

The amount of tocopherol may be about 0.01 to 1 part by weight based on 100 parts by weight of the total composition. If the content of tocopherol is too small, it is difficult to expect the role of an antioxidant caused by tocopherol, and if the content is too high, side effects such as skin rash may be caused. Therefore, it is preferable to use the above content.

In addition, in order to control the oil and moisture balance of the dermal tissue, the composition for treating the swelling line according to the present invention may include a collagen production adjuvant, such as thiamine, riboflavin, pyridoxine or niacin. The thymine, riboflavin, pyridoxine, and niacin are derivatives thereof, meaning thiamine HCl as chiamine, riboflavin phosphate sodium as riboflavin, pyridoxine hydrochloride as pyridoxine, and nicotinic acid as niacin. Nicotinamide can be used. The chiamine, riboflavin, pyridoxine and niacin may each be about 0.01 to 1 part by weight based on 100 parts by weight of the total composition.

On the other hand, the composition for the treatment of swelling filigree according to the present invention may be formulated as an infusion solution.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the present invention is not limited thereto.

Example  One

After 50 ml of saline solution (0.9%) is placed in a suitable 100 ml container, 8 g of glucose, 0.03 ml of retinol, 0.03 ml of ascorbic acid, 0.03 ml of tocopherol acetate, 0.03 ml of nicotinamide, 0.03 Ml of pyridoxine hydrochloride, 0.03 ml of riboflavin sodium phosphate and 0.03 ml of chiamine hydrochloride were added and mixed to prepare a composition for treating the dilatation line.

Example  2

Except for adding 2 g of glucose, the same composition as in Example 1 was prepared for the treatment of the swelling line.

Comparative example  One

Retinoid acid was applied to the damaged epidermis.

Comparative example  2

Erbium-YAG laser was used to thin the epidermis of damaged cell tissue.

Experimental Example  One. Swelling  Determination of the therapeutic effect of the therapeutic composition

The composition for treating the treatment of inflated streak prepared in Examples 1 and 2 was added to 20 or more patients with inflated streak once a month for 3 months to confirm whether the treatment of the inflated streak was performed.

1) Skin condition observation

The skin condition was observed before and after the infusion treatment composition prepared in Examples 1 and 2 was added. The state of any one patient is shown in FIG. As can be seen in Figure 2, it can be seen that the band of the swelling filigree that appeared red or white disappeared almost or completely (showing about 70% to 90% improvement).

2) sensory evaluation

Sensory evaluation was performed on the patients treated with the swelling tangles prepared in Examples 1, 2 and Comparative Example 1 and the patients treated by Comparative Example 2. In most patients, treatment with the swelling composition prepared in Examples 1 and 2 showed that the swelling band disappeared without side effects such as pigmentation and scarring, compared with the conventional swelling treatment. Evaluation was made (see Table 1).

Comparative Example 1 Comparative Example 2 Example 1 Example 2   Satisfaction with treatment 1.1 2.7 4.9 4.6   Skin cracks 1.05 1.85 2.90 2.75   Erythema, pigmentation 0 0.85 0 0   I) Treatment Satisfaction: Very Satisfied (5), Satisfied (4), Moderate (3), Almost Ineffective (2), Dissatisfied (1) ii) Skin Cracking: Almost Invisible (3), Blurry (2), Still (1) ⅲ) erythema, pigmentation occurs: occurs (1), does not occur (0)

1 is a cross-sectional view showing a cross section of skin tissue.

Figure 2 shows the skin condition before and after the addition of the composition for treatment of swelling filigree according to the present invention.

Claims (11)

glucose; Collagen production aids selected from the group consisting of retinoids, ascorbic acid, tocopherol, chiamine, riboflavin, pyridoxine, niacin and mixtures thereof; And a physiologically applicable solvent, comprising: The content of the glucose is 5 to 50 parts by weight based on 100 parts by weight of the total composition, thereby the osmolality of the composition is 500 to 1000 mOsmol / L, characterized in that the injection composition for treatment of swelling line. delete delete The injection composition of claim 1, wherein the physiologically applicable solvent is physiological saline or distilled water. According to claim 1, wherein the physiologically applicable solvent is 50 to 90 parts by weight based on 100 parts by weight of the total composition of the injection composition for treatment of swelling progenitor. delete According to claim 1, wherein the collagen production adjuvant is injectable composition for treatment of swelling progenitors, characterized in that it comprises 0.01 to 1 parts by weight with respect to 100 parts by weight of the total composition. delete delete delete delete

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