KR100876444B1 - Surface Modification of Artificial Joints and Artificial Joints - Google Patents

Abstract

An artificial joint and the surface modification of the artificial joint are provided, in which the titanium coating layer is formed even after the titanium coating layer is formed on the surface of the Ti alloy. An artificial joint in which the oxide film inducing the micro-arc oxidation is formed comprises: a Ti alloy(1); a titanium coating layer(2) which is applied on the Ti alloy and is formed in order to prevent the elution of the composition of the Ti alloy; an oxide film(3) of the porosity formed in the titanium coating layer by the micro-arc oxidation.

Description

A ARTIFICIAL JOINTS AND A METHOD FOR MODIFYING SURFACES OF A ARTIFICIAL JOINTS}

1 is an enlarged view of the surface of the artificial joint according to the present invention.

2 is a block diagram of a surface modification method of an artificial joint according to the present invention;

3 is a schematic view of an electron beam processing apparatus for forming a titanium coating layer according to the present invention.

Figure 4a is a scanning electron micrograph of a modified surface of the artificial joint induced microarc oxidation on a conventional titanium alloy.

Figure 4b is a scanning electron micrograph of the surface of the artificial joint modified by inducing microarc by depositing a titanium coating layer on the titanium alloy according to the present invention.

Figure 5a is a graph showing the XRD pattern of the specimen induced microarc oxidation at 250V on a conventional titanium alloy.

5b is a graph showing an XRD pattern of a specimen inducing microarc oxidation at 250V by depositing a titanium coating layer on a titanium alloy according to the present invention.

Figure 6 is a graph showing the elution amount of vanadium over time by inductively coupled plasma mass spectrometry in Test Example 1, Test Example 2, Comparative Example 1.

The present invention relates to a method of modifying the artificial joints and artificial joints, in particular by forming a titanium coating layer on the titanium alloy (TI6AL4V) can prevent the dissolution of aluminum (Al) and vanadium (V) harmful to the human body, the titanium The present invention relates to a bio-friendly and highly mechanically modified artificial joint and a surface modification method of the artificial joint, which can promote osteoadhesion due to the oxide film induced microarc oxidation in the coating layer.

The human body has joints as bones and bones that can be connected freely and move freely. When these joints are severely painful or degenerative due to degenerative arthritis, it is difficult to walk or daily life. The artificial joint is removed and inserted.

Various materials and alloys have been developed as appropriate materials for such artificial joints, but mainly titanium metal or alloys thereof are used. Titanium or alloys thereof are not only easy to process but also have excellent biocompatibility, mechanical strength and corrosion resistance, and are known to have suitable properties as biomaterials. In addition, the titanium alloy, TI6AL4V, which is widely used as a medical artificial joint material, is known to have a density of less than titanium and a strength of titanium of 140 MPa, whereas the titanium alloy of TI6AL4V is 880 MPa, which is about 6 times larger. Therefore, the titanium alloy TI6AL4V has been used for a long time as a suitable material for artificial joints because it has a mechanical strength that is not deformed or destroyed even under repeated loads and instantaneous pressures.

However, the titanium alloy has a long bonding time with the bone when implanted in the human body, and the metal ion melts into the living body after a long time after transplantation. In particular, the titanium alloy (TI6AL4V) is vanadium (V) and a long time after implantation in the human body. As aluminum (Al) melts into the human body, the vanadium (V) is an element harmful to the human body, and aluminum (Al) is pointed out as a cause of Alzheimer's disease.

In order to solve the above problems, a method of coating hydroxyapatite on a titanium alloy is proposed. Hydroxyapatite is very similar to the mineral component of human bone, and has good biocompatibility and bioactivity, so it shows good result for early bone adhesion. However, dissolution phenomenon of coated hydroxyapatite and drop of coating layer at interface Due to the continuous annual marginal bone resorption (failure) has been found to increase the failure rate eventually.

In addition, in order to solve the above problems, research is being actively conducted to prevent the dissolution of the composition of titanium alloy harmful to the human body by artificially forming an oxide film by performing a surface treatment on titanium or titanium alloy. Titanium reacts with oxygen when the surface is exposed to air to naturally form an oxide film, but the oxide film is thin and unstable. Therefore, the anodization method has been proposed as a method of artificially forming the oxide film, which can help to bond with the tissue while artificially forming the oxide film. The oxide film on the surface of titanium plays an important role in biocompatibility, has excellent corrosion resistance and chemical resistance, can play a catalytic role in organic or inorganic chemical reactions, and has a high dielectric constant, It can induce stronger van der Waals bonds.

Therefore, even though the oxide film can prevent the dissolution of the titanium alloy composition harmful to the human body to a certain level, there is still a dissolution of the composition of titanium alloy harmful to the human body, and furthermore, since the oxide layer obtained by the anodizing method has an amorphous structure. In case of anodizing the titanium alloy of TI6AL4V due to the high decomposition rate in the body, there is still a problem of dissolution of aluminum (Al) and vanadium (V) harmful to the human body.

On the other hand, in order to solve the above problems, a micro arc oxidation method (Micro Arc Oxidation) has been proposed to form a porous oxide film by a specific dielectric breakdown in the category of anodization. The principle is that at low voltages, an oxide film having a uniform and dense barrier layer structure is formed due to electrolysis, but when the oxide film is formed to a certain thickness or more, it no longer increases, and a very large electric field is applied to the oxide film and insulation breakdown occurs. When the voltage reaches the threshold, hydrogen is generated, microarc (flame) is generated in the minute region, insulation breakdown occurs in the oxide film and pores are formed, or the oxide film is formed by the microarc oxidation method on a titanium alloy of TI6AL4V. Even when formed, there is still a problem that elution of aluminum (Al) and vanadium (V) occurs.

The present invention has been made to solve the problems of the prior art, the object of the present invention after forming a titanium coating layer on the surface of the conventional titanium alloy is formed an oxide film inducing micro-arc oxide on the titanium coating layer It is to provide a method for surface modification of artificial joints and artificial joints.

Another object of the present invention is to provide a method for surface modification of artificial joints and artificial joints that can prevent the composition harmful to the human body by forming a titanium coating layer on the surface of the conventional titanium alloy.

Another object of the present invention is to provide a method for surface modification of artificial joints and artificial joints that can prevent the dissolution of aluminum (Al) and vanadium (V) harmful to the human body by forming a titanium coating layer on a titanium alloy of TI6AL4V.

Another object of the present invention is to form a titanium coating layer on the titanium alloy TI6AL4V by using physical vapor deposition method is possible to deposit a material having a high melting point, it is possible to deposit at a high speed to increase the production efficiency and reduce the product cost It is to provide an artificial joint and a method of surface modification of the artificial joint.

Another object of the present invention is not only to prevent the dissolution of aluminum (Al) and vanadium (V) harmful to the human body by the titanium coating layer, but also due to the oxide film induced micro-arc oxidation on the titanium coating layer, the bone adhesion and corrosion resistance Providing a method for surface modification of artificial joints and artificial joints which can promote, maintain bio-friendly and high mechanical strength, and prevent the dissolution of aluminum (Al) and vanadium (V), which are harmful to the human body. will be.

It is another object of the present invention to provide a method for surface modification of artificial joints and artificial joints which can prevent the titanium coating layer from peeling off from the titanium alloy of TI6AL4V by coating titanium, which is a composition similar to that of the titanium alloy of TI6AL4V. It is.

The present invention is implemented by the embodiment having the following configuration in order to achieve the above object.

According to the first embodiment of the present invention, the artificial joint of the present invention, the titanium coating, the titanium coating layer formed to be coated on the titanium alloy to prevent the dissolution of the composition of the titanium alloy, and the micro-coat on the titanium coating layer It characterized in that it comprises a porous oxide film formed by arc oxidation.

According to the second embodiment of the present invention, the artificial joint of the present invention, in the first embodiment, the titanium alloy is formed of titanium, aluminum and vanadium, the titanium coating layer is aluminum (Al) and the titanium alloy It is characterized in that it is formed to prevent the elution of vanadium (V).

According to a third embodiment of the present invention, in the artificial joint of the present invention, in the second embodiment, the titanium alloy is formed of TI6AL4V.

According to the fourth embodiment of the present invention, the artificial joint of the present invention is any one of the first to third embodiments, wherein the titanium coating layer is formed by physical vapor deposition.

According to a fifth embodiment of the present invention, the surface modification method of the artificial joint of the present invention, the coating layer forming step of forming a titanium coating layer to be coated on the titanium alloy to prevent the dissolution of the composition of the titanium alloy, the titanium It characterized in that it comprises an oxide film forming step of forming a porous oxide film by the microarc oxidation method on the coating layer.

According to a sixth embodiment of the present invention, in the fifth embodiment, the surface modification method of the artificial joint is characterized in that the titanium alloy is formed of titanium, aluminum (Al), and vanadium (V). .

According to the seventh embodiment of the present invention, the surface modification method of the artificial joint of the present invention, in the sixth embodiment, is characterized in that the titanium alloy is formed of TI6AL4V.

According to the eighth embodiment of the present invention, in the fifth embodiment, the surface modification method of the artificial joint according to the present invention, the oxide film forming step, 170V -290V so that the oxide film is not porous cracks are formed Characterized in that the voltage is formed.

According to the ninth embodiment of the present invention, the surface modification method of the implant of the present invention, in the fifth embodiment to eighth embodiment, characterized in that the coating layer forming step is formed by a physical vapor deposition method.

Applicants will now describe the embodiments in detail above.

1 is an enlarged view of the surface of an artificial joint according to the present invention.

Referring to Figure 1, the artificial joint of the present invention is a titanium alloy (1) and the titanium coating layer (2) attached to one surface of the titanium alloy (1) and the porous coating formed by microarc oxidation on the titanium coating layer (2) An oxide film 3.

The titanium alloy (1) is a material of artificial joints, and maintains the mechanical strength so as not to be deformed and destroyed even under repeated loads and instantaneous pressure imposed, and should be a material having high biocompatibility. The titanium alloy (1) is preferably used titanium alloy (1) of TI6AL4V excellent mechanical strength. The titanium alloy 1, which is TI6AL4V, is formed of aluminum formed from 6 parts by weight of itanium alloy weight 100 and vanadium formed from 4 parts by weight.

The titanium coating layer (2) is coated on the titanium alloy (1) to prevent the composition of the titanium alloy (1) that is harmful to the human body when the implant is implanted in the human body. In addition, by coating titanium, a material similar to that of the titanium alloy 1, the interface between the titanium coating layer 2 and the titanium alloy 1 is prevented from being separated. In particular, when the titanium alloy (1) is TI6AL4V, the titanium coating layer (2) is formed to prevent elution of aluminum (Al) and vanadium (V) harmful to the human body.

On the other hand, the titanium coating layer 2 is preferably formed by a physical vapor deposition method that can be deposited at a high speed to increase the manufacturing efficiency of the product and thereby lower the manufacturing cost. When the titanium alloy (1) is placed inside the chamber of the physical vapor deposition apparatus, the titanium target, which is a deposition material, is placed inside the chamber, and an electron beam is generated. Then, the target inside the chamber is melted and decomposed to form titanium on the surface of the titanium alloy (1). Titanium coating layer (2) of the form in which atoms and ions of are naturally bonded is formed.

The oxide film 3 is formed of a porous oxide film 3 on the surface of the titanium coating layer 2 by microarc oxidation. The oxide film 3 is stable in a living body, has excellent biocompatibility, and also reacts with cells. Showing a positive side is formed to prevent the composition of the titanium alloy (1) harmful to the human body from being eluted to prevent the harmful composition of artificial joints eluted with the titanium coating layer (2).

Microarc oxidation is a kind of electrolysis method, in which chemical reactions, electrical reactions, exothermic reactions, sintering, diffusion, and the like are known to occur all at once. When the electric field is applied to the specimen, a uniform and dense oxide layer is first produced by electrolysis at low voltage, and when the voltage reaches a threshold, microarc is generated and the oxide layer on the surface is destroyed. This breakdown occurs in a small area, and the heat released dissolves the oxide layer locally, the metal ions move to the surface, and the oxygen ions move into the substrate to form an oxide film through a chemical reaction. As a result, the crystallization is performed well, and the surface is rough and porous, so that the surface area is increased, thereby forming an artificial joint having good osteoadhesion and biocompatibility.

2 is a block diagram of the surface modification method of the artificial joint according to the present invention, Figure 3 is a schematic diagram of an electron beam processing apparatus for forming a titanium coating layer according to the present invention.

The implant according to the invention is surface modified by the method shown in FIG. 2.

1 to 3, the surface modification method of the artificial joint of the present invention includes an etching step (s1), a coating layer forming step (s2), an oxide film forming step (3).

The etching step (s1) is performed before the coating layer forming step (s2), which will be described later to make the deposition of titanium better, and is performed by an inert gas such as argon, neon, and the like, in particular argon ions. In general, when an ion beam current is applied while maintaining the pressure inside the chamber while argon gas is injected into the chamber after the titanium alloy is placed in the etching chamber, argon ions are generated inside the chamber to make the surface of the titanium alloy unstable. It is a step for better deposition of titanium on the titanium alloy (1).

The coating layer forming step (s2) prevents the composition of the titanium alloy (1) that is harmful to the human body from being eluted and the titanium coating layer (2) on the titanium alloy (1) so that the titanium coating layer (2) is not separated from the titanium alloy (1). Forming a step. The coating method for forming the coating layer may be sputtering and resistive heating evaporation during chemical vapor deposition and physical vapor deposition, and the titanium coating layer 2 of the present application uses an electron beam during physical vapor deposition. It is preferable to form by vapor deposition. Electron beam evaporation can be used to deposit materials with high melting point, high speed deposition, various depositions, and low thermal and electrical complexity when forming coating layers. There is this.

The oxide film forming step (s3) induces microarc oxidation on the surface of the titanium coating layer (2) to form a porous oxide film (3) in the composition of the titanium alloy (1), especially when the titanium alloy is TI6AL4V Elution of harmful aluminum (Al) and vanadium (V) can be prevented to increase biocompatibility, and the surface of the oxide film 3 is made porous so that the surface area is increased so as to have excellent bone adhesion.

Hereinafter, the present invention will be described in more detail. The following examples are only intended to present specific examples of the present invention, and the scope of the present invention should not be understood as being limited thereto. It should be considered that various other modifications and changes may be possible.

(1) Preparation of Psalms

Applicants tested the presence of elution of alumina (Al ₂ O ₃ ) and vanadium (V) after forming a titanium coating layer on the titanium alloy of TI6AL4V and inducing microarc oxidation.

1) Test Example 1

In the process chamber of the physical vapor deposition equipment (PVD), a substrate made of TI6AL4V is placed, and a titanium target (CP GRADE II Ti, manufactured by Metal Co., Ltd.), which is a deposition material, is placed in the crucible and 120 mA By generating an electron beam of the titanium target in the interior of the chamber was dissolved in the titanium coating layer of the titanium atoms and ions on the upper surface of the substrate was deposited on the substrate. At this time, the degree of vacuum was adjusted to 1 ~ 5 × 10 ^-6 Torr (torr), the deposition rate was set to 1 Å / sec average.

On the other hand, the titanium alloy substrate is 10mm × 10mm in width, the thickness of the plate was used in the form of a 2mm size, sandpaper to remove impurities on the surface of the substrate prior to the deposition of the titanium coating layer The surface was polished 3000 times, and the pressure in the chamber was increased to 1 × 10 ^-7 while the substrate was placed in an etching chamber for instability to make the surface of the substrate unstable, and the argon gas was injected into the chamber. With tor By applying an ion beam current of 90V-2A, argon ions were generated inside the chamber to etch the substrate surface.

In addition, after the titanium coating layer was deposited on the substrate, in order to form a porous oxide film, the substrate on which the titanium coating layer was deposited was fixed as an anode, stainless steel as a cathode, and 0.15 mole CA (Calcium) as an electrolyte for microarc oxidation. Acetate) and 0.02 mole Ca-GP (Calcium Glycerophosphate) dissolved in tertiary distilled water were used.

2) Test Example 2

In Test Example 1, a specimen was prepared under the same conditions as in Test Example 1 except that a titanium coating layer was deposited on both top and bottom surfaces of a substrate made of TI6AL4V.

3) Comparative Example 1

A specimen was prepared under the same conditions as in Test Example 1 except that the titanium coating layer was not deposited on a substrate made of a titanium alloy, which is TI6AL4V.

(2) Experimental method

1) Experiment 1: Surface appearance observation

Applicant observed the microstructure of the microarc oxidized specimen using Scanning electron microscope (JSM-6330F, JEOL, JAPAN) for Test Example 1. On the other hand, in order to find the optimal voltage to prevent the oxide film from cracking in Test Example 1, the microarc oxidation was performed at 150 V, 170 V, 290 V, and 320 V under the respective voltages of 660 Hz and duty of 10% for 5 minutes. Treated.

2) Experiment 2: Elution Observation of Alumina (Al ₂ O ₃ )

Applicants performed phase analysis on Test Example 1 and Comparative Example 1 using an X-ray diffractometer (XRD; X-ray Diffractometer, M18XHF-SRA, MAC Science, Japan).

3) Experiment 3 Elution Observation of Vanadium (V)

Applicants analyzed the elements using Inductively-coupled Plasma Mass Spectroscope, Elan 6100, Perkin-Elmer (ICP-MS) for Test Example 1 and Test Example 2, and sourced 6000K of argon. Plasma was used.

(3) Consideration

1) Figure 4a is a scanning electron microscope photograph of the surface of the artificial joint inducing the micro-arc oxidation to the conventional titanium alloy, Figure 4b is a titanium coating layer deposited on the titanium alloy according to the invention induced microarc oxidation Scanning electron micrograph with modified surface of artificial joint.

In Experiment 1, referring to FIG. 4A, FIG. 4A illustrates an oxide film having porous pores formed by inducing microarc oxidation without forming a titanium coating layer on a conventional titanium alloy.

Referring to FIG. 4B, after depositing the titanium coating layer on the titanium alloy of TI6AL4V, it was confirmed that a porous oxide film may be formed by microarc oxidation on one surface of the titanium coating layer. Therefore, it was confirmed that microarc oxidation is possible even after the titanium coating layer was formed on the titanium alloy.

On the other hand, in Experiment 1, when the oxide film is formed by the micro-arc oxide after the deposition of the titanium coating layer was examined for the voltage that the crack does not occur. The results are shown in Table 1 below. The dielectric breakdown did not occur at the microarc oxidation voltage of 150V, the pores were formed in the oxide film by the insulation breakdown from 170V, and the pores were formed due to the dielectric breakdown at 290V, but the crack was formed in the 320V. . Cracking can damage the long-term stability of the artificial joint, and if the artificial joint is damaged, the titanium coating layer can also corrode, so that the alumina and vanadium of the titanium alloy, TI6AL4V, can be released into the human body. It was found that the arc oxidation voltage is preferably in the range of 170V to 290V.

division  Microarc Oxidation Voltage (V) 150 170 290 320 Test Example 1 × ○ ○ ◇

* In Table 1, x denotes a state in which no pores are formed in the oxide film, ○ denotes a state in which pores are formed in the oxide film, and ◇ denotes a state in which cracks or surface defects occur.

2) Figure 5a is a graph showing the XRD pattern of the specimen induced the micro-arc oxidation at 250V in the conventional titanium alloy, Figure 5b is a titanium coating layer deposited on the titanium alloy according to the invention induced microarc oxidation at 250V This graph shows the XRD pattern of the specimen.

In Experiment 2, referring to FIG. 5A, Comparative Example 1 induced microarc oxidation without depositing a titanium coating layer on a titanium alloy, which is a conventional TI6AL4V. Alumina peak, which is an oxide of aluminum, was formed by an X-ray diffractometer. It was confirmed that the appearance at 2θ = 57˚. Therefore, it was confirmed that aluminum (Al), which is harmful to the human body, was eluted even though the oxide film was formed without depositing the titanium coating layer on the titanium alloy of TI6AL4V.

However, referring to FIG. 5B, Test Example 1 induced microarc oxidation after depositing a titanium coating layer on a titanium alloy of TI6AL4V. It was confirmed that the alumina peak did not appear at 2θ = 57 ° by an X-ray diffractometer. .

Therefore, the Applicant was able to confirm that it is possible to prevent the aluminum (Al) from being eluted due to the additional titanium coating layer.

3) Figure 6 is a graph showing the elution of vanadium over time by inductively coupled plasma mass spectrometry in Test Example 1, Test Example 2, Comparative Example 1.

In Experiment 3, as illustrated in FIG. 6, the amount of vanadium eluted with time was measured by inductively coupled plasma mass spectrometry (ICP-MS). As a result, in Comparative Example 1, in which the titanium coating layer was not deposited, about 280 ppb of vanadium was eluted after 3 hours, and in Test Example 1 in which the titanium coating layer was deposited only on one surface, about 150 ppb of vanadium was eluted, and the titanium coating layer was deposited on both surfaces. In Test Example 2, it was confirmed that about 50 ppb of vanadium was eluted.

Therefore, in Example 1 and Example 2 in which the titanium coating layer was deposited, the elution of vanadium was significantly reduced than in Comparative Example 1, and Example 2 in which the titanium coating layer was formed on two surfaces was compared to Test Example 1 in which the titanium coating layer was formed on one surface. It was confirmed that the elution of vanadium was significantly reduced. However, the reason why the elution of vanadium is not 0 in Test Example 2 is because the side of the four sides of the plate specimen is not coated with titanium. Therefore, if the titanium coating layer is formed in the entire contact with the human body, it is determined that vanadium will not elute.

4) In the above experiment, the applicant evaporates aluminum and vanadium which are harmful to the human body by depositing a titanium coating layer on the titanium alloy of TI6AL4V and forming a porous oxide film by microarc oxidation while using the conventional titanium alloy of high strength, TI6AL4V. The method of surface modification of artificial joints and artificial joints could be confirmed.

The present invention has the following effects by the above configuration.

The artificial joint and the surface modification method of the artificial joint of the present invention provides an effect of preventing the dissolution of aluminum (Al) and vanadium (V) harmful to the human body by forming a coating layer of titanium on the titanium alloy TI6AL4V.

The artificial joint and the surface modification method of the artificial joint of the present invention provide an effect of forming an oxide film inducing microarc oxidation on the titanium coating layer even after the titanium coating layer is formed on the surface of the conventional titanium alloy.

The artificial joint and the surface modification method of the artificial joint of the present invention forms the titanium coating layer on the surface of the conventional titanium alloy provides an effect that can prevent the composition harmful to the human body from eluting.

The artificial joint and the surface modification method of the artificial joint of the present invention forms an titanium coating layer on the titanium alloy TI6AL4V provides an effect that can prevent the dissolution of aluminum (Al) and vanadium (V) harmful to the human body.

In the artificial joint and artificial joint surface modification method of the present invention, by using a physical vapor deposition method to form a titanium coating layer on a titanium alloy of TI6AL4V, it is possible to deposit a material having a high melting point, and to deposit at a high speed, thus producing efficiency. This is high and provides the effect of reducing the product cost.

The artificial joint and the surface modification method of the artificial joint of the present invention can not only prevent the dissolution of aluminum (Al) and vanadium (V) harmful to the human body by the titanium coating layer, but also an oxide film inducing microarc oxidation in the titanium coating layer. Due to this, it is possible to promote osteoadhesion and corrosion resistance, maintain a bio-friendly and high mechanical strength state, and also provide an effect of preventing the elution of aluminum (Al) and vanadium (V) harmful to the human body.

The artificial joint and the surface modification method of the artificial joint of the present invention provides an effect of preventing the titanium coating layer from being peeled off from the titanium alloy of TI6AL4V by coating titanium, which is a similar composition but not completely different from the titanium alloy of TI6AL4V. .

Claims (9)

A titanium joint, a titanium coating layer coated on the titanium alloy to be formed to prevent elution of the composition of the titanium alloy, and an artificial joint comprising a porous oxide film formed by microarc oxidation on the titanium coating layer. . The method of claim 1, The titanium alloy is formed of titanium, aluminum and vanadium, the titanium coating layer is an artificial joint, characterized in that the titanium alloy is formed to prevent the elution of aluminum (Al) and vanadium (V). The method of claim 2, The titanium alloy is artificial joint, characterized in that formed from TI6AL4V. The method according to any one of claims 1 to 3, The titanium coating layer is an artificial joint, characterized in that formed by physical vapor deposition.        A coating layer forming step of forming a titanium coating layer to be coated on the titanium alloy to prevent elution of the composition of the titanium alloy, and an oxide film forming step of forming a porous oxide film by microarc oxidation on the titanium coating layer. Surface modification method of artificial joint. The method of claim 5, wherein the titanium alloy is formed of titanium, aluminum, and vanadium. The method of claim 6, wherein the titanium alloy is formed of TI6AL4V. The method of claim 5, wherein the oxide film forming step, Surface oxidation method of the artificial joint, characterized in that the oxide film is formed at a voltage of 170V -290V so that the porous pores are formed without cracking. The method of claim 5, wherein the coating layer forming step, Surface modification method of artificial joint, characterized in that formed by physical vapor deposition method.

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