KR100874591B1 - Cold storage container for medical - Google Patents

Abstract

A transportation container for cold storage of medical supplies is provided to improve the structure of the transportation container such that size of the transportation container is minimized, weight of the transportation container is lowered, and the transportation container is not influenced by an external temperature while consistently maintaining temperature suitable for transporting the medical supplies. A transportation container for cold storage of medical supplies(10) comprises: an inner packing box(21) which is formed to a size capable of storing the medical supplies, and which has an opening-and-closing door installed on one side thereof; an outer packing box(22) which is formed to a size capable of containing the inner packing box, and which has an opening-and-closing door installed on one side thereof; and a refrigerant(40) installed on respective inner peripheral surfaces of the inner and outer packing boxes to blow off cold air by itself. The inner and outer packing boxes are formed of heat insulation material to constantly maintain temperature of the medical supplies while moving the medical supplies.

Description

Cold Storage Container for medical

1 is a perspective view of a conventional pharmaceutical cold storage container.

Figure 2 is a perspective view showing a first embodiment of the drug product cold storage container according to the present invention.

Figure 3 is an exploded perspective view of the first embodiment according to the present invention.

4 is a cross-sectional view taken along the line A-A 'of the first embodiment according to the present invention;

Figure 5 is a plan view showing a bottom box in the inner packing box of the second embodiment according to the present invention.

Figure 6 is a plan view showing the upper box in the inner packing box of the second embodiment according to the present invention.

7 is a cross-sectional view taken along line B-B 'of a second embodiment according to the present invention;

8 is an exploded perspective view of a second embodiment according to the present invention;

Figure 9 is a perspective view showing a third embodiment of the drug product cold storage container according to the present invention.

10 is a cross-sectional view taken along line C-C 'of the third embodiment according to the present invention;

11 is a graph showing the temperature change with respect to the time of the present invention and the conventional transport container at room temperature (22 ℃).

12 is a graph showing the temperature change with respect to the time of the present invention and the conventional transport container at the harsh temperature (37 ℃).

<Explanation of symbols for the main parts of the drawings>

1: Ice 10: Medicine (cell therapy)

21: Inner box 21-1: Refrigerant input groove

21-2: Ventilation hole 21-3: Drug mounting groove

22: outer packaging box 23: top

24: Bottom 25: Girl hook

26: String 30: net pocket

30-1: Zipper 40: Refrigerant

41: Refrigerated refrigerant 42: Refrigerated refrigerant

60: frozen probe sticker 70: temperature fading label

The present invention relates to a refrigerated transport container for drug storage required for refrigerated storage, and more particularly, by installing a box containing the drug and a refrigerant for ejecting cold air in the box containing the box on the inner peripheral surface of each box, The present invention relates to a pharmaceutical refrigerated transport container which maintains a temperature suitable for the following continuously for a long time, minimizes the size of the transport container, lowers weight, and is not affected by external temperature.

In general, medicines are medicines used to treat illnesses. They should be stored at appropriate temperatures depending on their type and use, and can sometimes be maintained during transport.

In particular, Cell Therapy Products can be used to 'promote or screen living autologous, allogenic, or xenogenic cells in vitro or otherwise in order to restore the function of cells and tissues. It is a new concept medicine used for the purpose of treatment, diagnosis and prevention by changing the characteristics, etc. It is used to collect and proliferate somatic cells of the patient, another person or other animals, or differentiate stem cells into desired cells for treatment. It has a wide range of applications and has infinite possibilities in the treatment of various intractable diseases such as burns, cancer and dementia.

Cell therapy is manufactured by a manufacturer trained in a rigorous manufacturing facility because such cell therapy requires transplantation of fleshy cells in the body to restore or supplement the original function of the cell.

However, even if a manufacturer trained in a rigorous manufacturing facility makes a product using excellent raw materials and materials and satisfies a strict quality test, the original product performance is difficult to expect once the storage and transport conditions are not suitable.

If the temperature drops below zero in the process of storing or transporting cell therapies, the cell wall is destroyed and the viability of the cells is lowered. On the contrary, when the cells are left at room temperature, the cell activity is temporarily increased and metabolism proceeds. Metabolic by-products lead to a sharp decrease in cell activity and reduced survival rates.

In addition, if the temperature changes frequently due to the temperature outside the container, the cell activity is negatively affected.

In other words, the temperature change during transport is a cause of a single organism, the cell is affected by its activity, the efficiency is lowered, and furthermore, a quality drug at the time of manufacture is the cause of the quality degradation in the transport process.

Therefore, it is important to maintain the proper temperature for the transport container of medicine to stably maintain the survival rate and activity.

For example, the titration temperature of a cell therapeutic agent in medicine is 2-8 degreeC.

In the present invention will be described with reference to experimental data with a sample of the cell therapeutic agent (10) in the drug.

1 is a perspective view showing a transport container of a conventional cell therapy agent (10).

Conventionally, in order to maintain an appropriate temperature (2 ~ 8 ° C), ice (1) or dry ice is used in a packing box 22 made of a heat insulating material such as strofoam.

On the other hand, the cell therapeutic agent 10 has a very limited shelf life within a few days due to the inherent characteristics of the cell. In the case of international transportation, air transportation is generally used, which has the fastest travel time. Due to the high cost of transportation, the volume or weight of the box must also be carefully considered.

However, in order to transport the cell therapeutic agent 10 over a long distance, an amount of ice (1) is required to extend the refrigerating time sufficiently, and as the volume of the container increases in proportion to the amount of ice (1), Transportation costs also increase.

In addition, since the cell therapeutic agent 10 is configured to be stored in ice 1 or dry ice, the cell therapeutic agent 10 is in contact with the ice 1 or dry ice, and the cells freeze and melt, which adversely affects the survival rate of the cells. There is a disadvantage of giving.

And the above problems are not limited to the silk cell therapy (10), but also applicable to the transport of organs or medicines required for organ transplantation to maintain the proper temperature.

The present invention is to solve the problems of the prior art as described above, by providing a box containing a medicine and a refrigerant for ejecting cold air in the box containing the box on the inner circumferential surface of each box, to maintain a temperature suitable for transporting the medicine Its purpose is to provide pharmaceutical refrigerated containers suitable for long distance transportation such as international transportation or air transportation by minimizing the size of the container, reducing the weight, and improving it so as not to be affected by the external temperature.

Still another object of the present invention is to provide a refrigerated transport container for medicine that can prevent damage or breakage due to impact during transport.

The present invention is to form a double insulation chamber so that the freezing / refrigerated medicines to maintain a constant storage temperature during the moving time, and the drug storage means is installed on one side opening and closing door to store the medicine; The object is achieved to provide a drug storage container for transport, characterized in that made of a refrigerant which is installed on each inner circumferential surface of the dual drug storage means consisting of itself to release cold air.

In addition, the frozen probe sticker to determine whether the temperature of the medicine drops to the center of one side of the drug storage means, that is, the drug is placed in the freezing position; And if the room temperature of the inner packaging box is the appropriate temperature is green, and if the room temperature is out of the proper temperature it is preferable to configure by further attaching a temperature fading label that is blue.

The inside of the drug storage means is fixed to each of the eight elastic strings in eight corners to maintain the middle temperature of the upper and lower portions to float in the middle of the medicine to freeze, absorbing the shock generated during the movement so that the medicine is not broken It is preferable to.

Hereinafter, the configuration of the present invention will be described in detail with reference to the accompanying drawings.

First, Figure 2 is a perspective view showing a first embodiment of a drug storage container according to the present invention, Figure 3 is an exploded perspective view of the first embodiment according to the present invention, Figure 4 is a first embodiment of the present invention A-A 'cross section.

The first embodiment of the present invention and the inner packing box 21 is installed to open and close the door to the size to hold the drug (10); An outer packaging box 22 having an opening and closing door installed at one side thereof in a size to accommodate the inner packaging box 21; The inner packaging box 21 and the inner peripheral surface of the outer packaging box 22 is composed of a refrigerant 40 to eject the cold air itself.

The inner packaging box 21 and the outer packaging box 22 is formed of a heat insulating material to maintain a constant temperature of the medicine 10 during the moving time.

Refrigerated refrigerant 41 applied to the present invention is stored in the refrigerator, the refrigerant refrigerant 42 is stored in the freezer for a sufficient time to form a plurality of solid state (for example, dry ice) square plate shape.
In the present invention, the first outer packaging box 22 is made using the insulation material having a thermal insulation effect such as styrofoam, and then the refrigerant is filled with the refrigerant 42 and then sealed. Thereafter, the secondary inner packaging box 21 is made by using the insulating material having an insulation effect, and the refrigerated refrigerant 41 is filled therein and then sealed, and the final medicine 10 is inside the final inner packaging box 21. Will be kept in place.

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Hereinafter, referring to FIG. 3, the assembling process of the refrigerated transport container for medicines 10 according to the first embodiment will be described. First, the frozen refrigerant 42 is attached to the bottom and wall surfaces of the outer packaging box 22, and the inner packaging box is provided. Insert 21 and then attach the refrigerated refrigerant 41 to the bottom and wall of the inner packaging box 21 in the same manner, and then place the medicine 10 on the refrigeration refrigerant 41 and the inner packaging box 21. The top surface of the refrigerating refrigerant 41 and the inner packaging box 21 is sealed by inserting the upper opening of the seal, and the top surface of the frozen refrigerant 42 and the outer packaging box 22 is sealed thereon.

The cold storage container of the first embodiment configured as described above has the outer packaging box 22, the frozen refrigerant 42, the inner packaging box 21, and the refrigeration refrigerant 41 in order to release the cold air in a double manner. The temperature is insulated from the outside to maintain a constant temperature for a long time.

Next, the configuration of the second embodiment of the present invention will be described in detail with reference to the drawings.

First, Figure 5 is a plan view showing the bottom box in the inner packaging box of the second embodiment according to the present invention, Figure 6 is a plan view showing the upper box in the inner packing box of the second embodiment according to the present invention, Figure 7 Is a cross-sectional view taken along line B-B 'of a second embodiment according to the present invention, and FIG. 8 is an exploded perspective view of a second embodiment according to the present invention.

Compared to the first embodiment of the medicine cold storage container according to the second embodiment of the present invention and the other configuration and its operation is only the structure of the inner packaging box 21 is slightly different.

Hereinafter, the structure of the inner packing box 21 of the second embodiment will be described in detail.

The inner box 21 is a refrigerant injection groove (21-1) formed so as to put the refrigeration refrigerant 41 into the left and right inner peripheral surface of the inner box; An upper plate 23 formed to place a refrigeration refrigerant 41 on an upper surface of the inner packing box 21; And a lower plate 24 to cover the refrigerating refrigerant 41 on the lower surface of the inner packing box 21.

The coolant injection groove 21-1 is provided with a ventilation hole 21-2 formed to allow the cool air to escape from the refrigerating cooler 41 and directly transfer the cool air to the medicine 10.

The upper plate 23 and the lower plate 24 is provided with a medicine mounting groove 21-3 to be fixed to the drug / 10 up / down.

The medicine mounting groove 21-3 is provided with a ventilation hole 21-2 communicating with the refrigerating refrigerant 41 mounted above and below the upper plate 23 and the lower plate 24.

Hereinafter, referring to FIG. 8, the assembling process of the refrigerated medicine container according to the second embodiment will be described. In the same manner as in the first embodiment, the refrigerant refrigerant 42 and the inner packing box 21 are stored in the outer packing box 22. And insert the refrigerating refrigerant 41 into the refrigerant feeding groove 21-1 of the inner packing box 21, and then put the lower plate 24 on the lower side of the cooling box 41 under the inner packing box 21. Insert the medicine 10 into the medicine mounting groove 21-3 so that the upper portion of the medicine 10 enters the medicine mounting groove 21-3 formed in the upper plate 23, the inner packaging box 21 The top surface of the refrigerating refrigerant 41 and the inner packaging box 21 are sealed by inserting the upper opening and closing, and the top surface of the refrigerating refrigerant 42 and the outer packaging box 22 is sealed thereon.

The refrigerated transport container of the second embodiment configured as described above is provided with the outer packaging box 22, the frozen refrigerant 42, the inner packaging box 21, and the refrigeration refrigerant 41 in order, so that the cold air is discharged in duplicate. The temperature is insulated from the outside to maintain a constant temperature for a long time, as well as by further forming a refrigerant injection groove (21-1) and medicine mounting groove (21-3) in the inner packaging box 21, This is to fix the refrigerant 41 and the medicine 10 so as not to flow during movement.

In addition, the ventilation holes 21-2 are formed in the inner circumferential surface of the inner packing box 21 for fixing the refrigerated refrigerant 41, so that the cold air of the refrigerated refrigerant 41 can be delivered to the medicine 10 and delivered. To do this.

Next, the configuration of the third embodiment of the present invention will be described in detail with reference to the drawings.

First, Figure 9 is a perspective view showing a third embodiment of the drug storage container according to the present invention, Figure 10 is a cross-sectional view of the third embodiment C-C 'according to the present invention.

Comparing the drug storage container and the first embodiment according to the third embodiment of the present invention compared to the other configuration and its action is the same as the net bag 30 that can hold the drug (10) the inner packaging box ( Only one structure, which is fixed at the eight corners of 21) and floats in the middle, is somewhat different.

Hereinafter, the structure of the inner packing box 21 of the third embodiment will be described in detail.

Opening door is formed in one side so that the product size can be put into a variety of medicines 10 and the net bag 30 having a filler function; Hanging hook 25 is fixed to the upper / lower eight corners of the inner box (21); And connecting the edge and the hook 25 of the net bag 30 to float the net bag 30 to float in the center of the inner packing box 21 and has a connection so as to absorb the shock during transport It consists of a string 26.

In addition, the net bag 30 is attached to the zipper 30-1 to the opening and closing door so as not to fall to the outside in the transport process after the medicine (10) enters.

In addition, at the center of the upper surface of the inner packaging box 21, that is, the position at which the medicine 10 is to be placed, the frozen probe sticker 60 and the inner packaging to check whether the temperature of the medicine 10 has dropped below zero. When the room temperature of the box 21 is a proper temperature, the green color is displayed, and when the room temperature is out of the proper temperature, a blue color fading label 70 is attached.

Hereinafter, referring to FIG. 10, the assembling process of the refrigerated medicine container according to the third embodiment will be described. In the same manner as in the first embodiment, the refrigerant refrigerant 42 and the inner packing box 21 are stored in the outer packing box 22. And insert the refrigeration refrigerant 41 in turn, by connecting the eight hooks 25 and the net bag 30 with the connecting string 26 to float the net bag 30 in the center, of the net bag 30 Put the medicine (10) through the opening and closing door and locked with a zipper (30-1), and then sealed by inserting the upper surface of the refrigerated refrigerant 41 and the inner packaging box 21 in the upper opening and closing of the inner packaging box 21, The upper surface of the frozen refrigerant 42 and the outer packaging box 22 is sandwiched and sealed thereon.

In addition, when the transport is completed or when the transportation is completed, the top surface of the outer packaging box 22 and the frozen refrigerant 42 are opened to check the color of the frozen probe sticker 60 attached to the upper surface of the inner packaging box 21, if white. Make sure it is not frozen during transportation, and if it is red, check that it is frozen or frozen. In addition, by checking the temperature discoloration label 70, if it is blue, it confirms that the current internal temperature is out of the proper temperature (2-8 ° C.), and if it is green, the current internal temperature maintains the proper temperature (2-8 ° C.). Check it.

The refrigerated transport container of the third embodiment configured as described above has the outer packaging box 22, the frozen refrigerant 42, the inner packaging box 21, and the refrigeration refrigerant 41 installed in this order, so that the cold air is discharged in double. The temperature is insulated from the outside to maintain a constant temperature for a long time, as well as the center of the net bag 30 with a connecting strap 26 having elasticity, the impact generated during movement without supplementing the filler separately The lower end of the inner packaging box 21 is lowered to below zero, and the medicine 10 is frozen, but the center is maintained at 2-8 ° C., so that the net bag 30 is leverated in the center, and the net bag ( 30) to accommodate a variety of sizes of medicines (10) together, the medicine 10 to maintain the intermediate temperature of the upper end and the lower end of the inner box (21).

In addition, by attaching the frozen probe sticker 60 and the temperature discoloration label 70 without the need to install a separate instrument, whether the drug (10) has ever frozen while moving or the current storage temperature is appropriate according to the change in color You can see right away.

An embodiment of the present invention and the conventional medicine cold storage container presented above will be described with reference to the drawings the results of experiments at room temperature (22 ℃) and harsh temperature (37 ℃).

Drug (10) used in this experiment is a cell therapy and the appropriate temperature is 2 ~ 8 ℃.

11 is a graph showing the temperature change with respect to the time of the present invention and the conventional transport container at room temperature (22 ℃), Figure 12 is a temperature change with respect to the time of the present invention and the conventional transport container at the harsh temperature (37 ℃) Is a graph.

First, in the graph of Figure 11, the solid line represents the drug storage container of the present invention, the dotted line represents a conventional drug container, the effective temperature range of the drug storage container is 2 ~ 8 ℃.

As can be seen through the graph of Figure 11, the cold storage container of the present invention takes the time to drop the temperature to the first temperature (10) to the first 8 ℃ 40 degrees, the lowest temperature to drop to 2.3 ℃ The time is about 14 hours from the start of the test, after which the refrigerated transport container in the conventional medicine refrigerated transport container lasts for 8 hours to about 8 hours after the first time the medicine (10) is put into the first 8 ℃ is about 18 minutes After that, the temperature continued to fall, and then it dropped to the lowest temperature of -3.9 ℃ in 1 hour and 30 minutes, and then gradually increased in temperature to maintain 2 ~ 8 ℃ for about 8 hours, and then exceeded 8 ℃ at 72 hours for 72 hours. After that, it can be seen that the temperature rises to the same level as the external temperature.

Looking at the graph of Figure 12, the cold storage container of the present invention takes about 50 minutes for the first time the temperature is lowered to 8 ℃ after the drug (10), the time taken to drop to the lowest temperature 2.5 ℃ test It starts at about 14 hours and 30 minutes, and then it lasts 78 hours at 2 ~ 8 ° C, whereas the conventional medicine cold storage container has a temperature of about 18 minutes when the temperature drops to the first 8 ° C after the first medicine 10 is added. After that, the temperature continues to drop, and after 1 hour and 30 minutes, it drops to the lowest temperature of -3.5 ° C. After that, the temperature gradually increases to maintain 2 to 8 ° C for about 7 hours, and then exceeds 8 ° C in 14 hours and 30 minutes. After 72 hours, it can be seen that the temperature rises to 32 ° C, similar to the external temperature.

That is, in the past, since the amount of ice 1 was excessively required for long-distance movement, the initial temperature dropped sharply and dropped below freezing, and the duration of the effective temperature was also shortened. By constructing the refrigeration / freezing refrigerants 41 and 42 in the boxes 21 and 22, not only the effective temperature range is maintained for 84 hours, but also the cell activity can be maintained well because it does not fall below zero, and is almost unaffected by the external temperature. Can be confirmed.

As described above, according to the present invention, the box containing the medicine (10) and the refrigerant 40 for ejecting the cold air in the box containing the box is installed on the inner peripheral surface of each box, the cold air is released from the double The temperature is insulated from the outside has the effect of continuously maintaining a temperature suitable for transporting the medicine (10) for a long time.

In addition, the size of the container can be minimized and the weight can be reduced, and the medicine 10 can be prevented from being damaged or broken in the impact generated during transportation without separately replenishing the filler.

In addition, the net bag 30 can contain a variety of medicines (10) in size, the drug (10) has the effect of preventing the freezing by maintaining the intermediate temperature of the upper end and the lower end of the inner packaging box (21). .

In addition, by attaching the frozen probe sticker 60 and the temperature discoloration label 70 without installing a separate measuring instrument, the medicine 10 has been frozen during movement or the current storage temperature is appropriate according to the change of color. You can see the effect.

Claims (10)

delete delete delete delete A double insulation chamber is formed to maintain a constant storage temperature during the moving time, and a medicine storage means having an opening and closing door is provided at one side to store the medicine, and the medicine storage means is formed of an insulation material to store the medicine. An inner packing box having opening and closing doors on one side; And an outer packaging box formed of a heat insulating material and having an opening and closing door installed at one side thereof to contain the inner packaging box, and installed on each inner circumferential surface of the dual drug storage means, and having a coolant that emits cold air by itself. In the container for attaching the refrigeration refrigerant to the inner circumferential surface of the inner packaging box, the refrigerant is attached to the inner circumferential surface of the outer packaging box to transport the medicine in a frozen / refrigerated state, The inner box 21 is a refrigerant injection groove (21-1) formed so as to put the refrigeration refrigerant 41 into the left and right inner peripheral surface of the inner box; An upper plate 23 formed to place a refrigeration refrigerant 41 on an upper surface of the inner packing box 21; And a lower plate (24) to cover the refrigeration refrigerant (41) on the lower surface of the inner packing box (21). The method of claim 5, Refrigerating medicines, characterized in that the refrigerant injection groove (21-1) is further formed with a vent hole (21-2) is formed so that the cold air from the refrigerated refrigerant 41 can be delivered directly to the medicine (10) Container. The method of claim 5, The upper plate (23) and the lower plate (24) is a cold storage container for medicine, characterized in that it further forms a drug mounting groove (21-3) to be fixed to the drug (10) up / down. The method of claim 7, wherein The medicine mounting groove 21-3 may further include a ventilation hole 21-2 which communicates with the refrigeration refrigerant 41 mounted on the upper and lower sides of the upper plate 23 and the lower plate 24. Container. The method of claim 5, An inner surface of the inner packing box 21 and a net bag 30 having an opening and closing function formed on one side to accommodate a container of a variety of product sizes and having a filler function; A hook ring 25 fixed to eight corners of the inner box 21; And by connecting the edge of the net bag 30 and the hook ring 25 to float the net bag 30 to float in the center of the inner packaging box 21 to maintain the intermediate temperature of the upper and lower parts so as not to freeze the medicine And, cold storage container for medicine, characterized in that it further comprises a connection strap 26 to absorb the shock generated during transport. The method of claim 9, The net bag 30 is a cold storage container for medicine, characterized in that the zipper (30-1) further attached to the opening and closing port of the net bag 30 so as not to fall to the outside in the transport process after entering the drug (10).

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