KR100843007B1 - Medical arrangement - Google Patents

Abstract

A syringe mechanism for ejecting liquid from a high pressure source, comprising: a housing; A pressure chamber having a pressure passage for receiving at least one piston therein, a front end opening for ejecting liquid, and having a strength sufficient to withstand liquid pressure. The instrument is separate from the pressure chamber and further comprises a storage chamber for the liquid or liquid precursor material component and a conduit between the pressure chamber and the storage chamber. The pressurization mechanism 26 in the housing is arranged to exert a force directly or indirectly on the piston in the pressure barrel to generate liquid pressure. At least a portion of the pressure chamber, the piston and the conduit are arranged as a unit, the unit and the housing of the unit in a position allowing fluid connection through the conduit between the storage chamber and the pressure chamber and allowing the pressurizing mechanism to act on the piston. It has a corresponding fitting portion that allows for detachable attachment.

Description

Syringe mechanism and unit and liquid discharge method {MEDICAL ARRANGEMENT}

The present invention relates to a syringe mechanism, a syringe unit with a pressure chamber, and a method of carrying out the injection, according to the preamble of the independent claim.

The principles of the present invention can be used in connection with any syringe which requires a high level of pressurization of the liquid to be injected. High pressure may be required to release high viscosity products such as, for example, oils, gels, dough, amorphous or suspended forms of products for dental purposes or to form slow releases into the body. Another major syringe form that requires high pressure is a jet injector for penetrating the skin without needles of pressurized liquid, as described below. Although the present invention is described with respect to this form of jet injection for convenience, it is to be understood that the present invention is not limited to this and can also be used in other high pressure applications.

Ejection injection devices for subcutaneous ejection injection of medical liquids through the skin surface or mucosa of humans or animals under high pressure sufficient to pressurize the liquid to a predetermined depth in the tissue below the skin surface or mucous membranes have previously been known in the art. It is.

Multiple short syringe instruments utilizing the jet injection principle are known from US Pat. No. 2,821,981. In such known instruments, the liquid to be injected is loaded from the proximal fluid drug chamber, such as in the form of a conventional syringe, into an end pressure chamber, ie an ampoule. One mechanism is used to transport the liquid from the liquid chamber into the pressure chamber, and the other mechanism is used to perform the injection. No return valve is provided in the delivery bore to ensure no backflow occurs. The mechanically complex structure of the syringe mechanism is expensive to manufacture. Another disadvantage of this type of complex mechanical instrument is the difficulty of assembling the instrument in a sterile environment. Today there is a need to manufacture non-disposable (reusable) parts that may be contaminated during injection. This demand is very difficult to meet for instruments of the type disclosed in US Pat. No. 2,821,981 or for mechanically complex instruments of this type due to the large number of different parts used to make the instrument. US Patent No. 3,138,257 discloses a syringe mechanism similar to US Patent No. 2,821,981.

U. S. Patent No. 4,447, 225 discloses a multi-dose ejection syringe suitable for receiving a drug bottle or potion bottle, wherein drug liquid from the drug bottle or potion bottle is carried into a delivery chamber. The drug is then pumped through the one-way valve to the drug release chamber via the cannula. Next, the drug is prepared for ejection injection release, which is effected by imparting ejection force on the drug liquid and thus releasing this liquid through the orifice of the ejection syringe. One disadvantage of the ejection syringe disclosed in US Pat. No. 4,447,225 is that it is structurally complex, such as two delivery steps of drug liquid prior to injection, and therefore expensive to manufacture.

US Patent No. 2,591,046 discloses a hypodermic syringe assembly with two chambers separated by a bypass section. The liquid drug is delivered into the end chamber via the bypass section. There is no separate chamber that can provide different properties, for example resistance to high pressure.

Liquid drugs for injection are usually stored in glass containers before they are loaded into syringes for injection. The rubber seal then seals the glass container. Thus, the liquid drug is only in direct contact with glass and rubber. The main reason for not using plastic material as a material for drug storage containers is that the plastic material does not provide a fully closed seal with respect to the oxygen moving into the container or the components exiting the container. In addition, the components at the time of manufacture can be disposed in the plastics material to affect the liquid stored in the container. Another reason is that the plastic material may release unacceptable trace constituents in the manufacture of injectables. The above mentioned disadvantages associated with plastic materials used for medical storage containers are only relevant when using plastic containers, for example, during typical medical storage times up to about two years. In the case of using a plastic material such as, for example, a syringe, the liquid drug is only in contact with the plastic material when the injection is performed, and the above-described disadvantages may not be identified.

For ejection syringes using glass containers, the glass container must withstand the high pressure used to release the liquid from the container. Next, the glass container is preferably made of rigid glass, which increases the cost. In contrast, plastic materials readily provide the necessary properties for pressure chambers such as strength and resistance with a low risk of fracture. In addition, the glass material for the storage chamber and the plastic material for the pressure chamber are suitable for disposable single use parts.

It is an object of the present invention to facilitate the use of a syringe instrument which is less expensive to manufacture than is known in the art. It is a further object of the present invention to provide an instrument which does not have the above mentioned disadvantages with regard to the sterilization treatment of parts of the instrument. Another purpose is suitable for prefilling with drugs, allowing storage over a long period of time prior to injection, and ensuring that all surfaces of the device and its parts in contact with or in contact with the drug can be kept sterile during manufacture, storage and use. It is to provide a syringe mechanism. Another object is to provide a device suitable for multiple dose injections from a storage chamber. Another object is to provide a mechanism suitable for easy replacement and disposal of contaminated parts during injection. It is a further object of the present invention to provide an instrument having a sterilizing component which cannot be reused to prevent unauthorized sterilization and resale of an instrument already used which may be dangerous to the patient. It is also an object of the present invention to provide a corresponding method for releasing liquid from a high pressure source.

Summary of the Invention

The above object is achieved by a syringe mechanism according to the features of the independent claims of the claims, a syringe unit with a pressure chamber, and a method of carrying out the injection. Preferred embodiments are disclosed in the dependent claims.                 

Thus, convenience for use in a syringe instrument is achieved by having some removable parts and being easy to manufacture. Syringes can be used in all high pressure syringe applications, can be prefilled with drugs, stored without contamination of drugs, and can be manufactured, stored and used under sterile conditions.

Preferably, the syringe mechanism according to the invention is suitable for multiple dose infusion. A separate unit comprising a pressure chamber that cannot be reused. The used unit is discarded after use and a new unit is attached to the syringe housing if a new injection is needed.

According to a preferred embodiment of the present invention, the liquid is pressurized from the storage chamber into the pressure chamber, so that no suction of the liquid into the pressure chamber is carried out so that it is not structurally more complicated.

According to another preferred embodiment, the mechanism is suitable for the administration of a liquid drug separate from the infusion mechanism.

Information from the dose setting unit regarding the dose volume carried from the storage chamber to the pressure chamber via the liquid conduit is supplied to the control device, which then generates a control signal, such as an electrical signal or mechanical movement, to the pressurizing mechanism. This control signal controls the movement of the piston in the pressure chamber, moving the piston to a position where no air remains in the pressure chamber.

According to another embodiment of the invention, there is provided a mechanical dosage unit for use by, for example, rotational movement. This movement is stored in a machine (or electronic memory) for use by the pressing mechanism.

1a to 1c schematically show the different steps of the method according to the invention,

2a and 2b show a syringe mechanism according to a first embodiment of the invention,

2c and 2d show a control device in a similar mechanism;

3a to 3e show a syringe mechanism according to a second embodiment of the invention,

4a and 4b are cross-sectional views of a variant embodiment of the bypass section according to the invention,

5 illustrates a multiple dose syringe instrument according to the present invention;

6 shows a separation unit according to the invention,

7A-7F illustrate mechanisms for dose setting, de-aeration and infusion usable in the device embodiment of FIG. 3, FIGS.

8 schematically shows a prior art threaded plunger rod;

9A-9D schematically depict an alternative embodiment of that shown in FIG. 7 as suitable for use with a threaded plunger rod;

10 shows schematically a modified ram sleeve for a parallel device.

Corresponding features have the same reference numerals in all the figures.

The basic steps in the method according to the invention are shown schematically in FIGS. 1A-1C. The pressure chamber 2 comprises a pressure cylinder 4 having a front end opening 6 for ejecting liquid, an opening 8 for receiving a liquid drug 10 from a storage chamber (not shown); And a piston 12 sealingly inserted into the pressure cylinder.

FIG. 1A shows the loading step when a certain volume of liquid is inserted into the pressure barrel through the opening 8. The inserted volume is smaller than the volume of the pressure cylinder on the piston 12. At this stage, the piston is in its loaded position. The upright position of the pressure chamber together with the surface tension prevents the conveyed liquid from escaping through the opening 6. As shown in the figure, the opening makes it possible to fill the pressure barrel from the bottom, forcing air in the direction toward the opening in proximity to the piston.

1B shows a sealing step in which the piston 12 is moved from the loaded position to the sealed position to seal the opening 8 from the storage chamber. The distance traveled by the piston is related to the volume of liquid drug, and substantially all air is released from the pressure chamber through the front end opening when the piston is in its sealed position. The figure shows a situation where the maximum dose of liquid is delivered into the pressure chamber. If the dose is lower, the piston is of course in the more distal position

FIG. 1C shows the ejection step where a force is applied on the piston to pressurize the piston in a distal direction, whereby the liquid drug is ejected as liquid ejection 14 through the front end opening.

2A and 2B show a syringe mechanism according to a first embodiment of the present invention. A syringe mechanism for ejecting liquid from a high pressure source is shown to include a pressure chamber 2, which pressure chamber 2 receives at least one pressure piston 12 inserted therein. 4) and a front end opening 6 for ejecting the liquid 8. The pressure chamber is made of sufficient strength to withstand liquid pressure during injection, preferably disposable, and made of plastic. The apparatus further includes a storage chamber 16 that is separate from the pressure chamber for the liquid or liquid precursor component. Preferably the storage chamber is made of glass and has a cylindrical shape. The storage chamber has a membrane 18 at one end and a movable sealed storage piston inserted at the other end. The membrane and the piston surround the liquid. Conduit 22 is disposed between the pressure chamber and the storage chamber. Preferably, the conduit is an integral part of the pressure chamber and comprises a needle 23 having a channel connected to the conduit. The needle is suitable for forming a fluid connection between the storage chamber 16 and the pressure vessel 4 through the thin film 18 of the storage chamber. The instrument also includes an administration unit 24, a pressurization mechanism 26 and a control unit 28. The dosing unit is adapted to force a volume on the storage piston inside the storage chamber to deliver a predetermined volume of liquid from the storage chamber into the pressure vessel via a conduit. The volume delivered depends on the distance d traveled by the storage piston. The position of the storage piston when a single dose is delivered is indicated by dashed lines. The pressurizing mechanism is configured to exert a force on the pressure piston in the pressure barrel to produce liquid pressure. The pressurizing mechanism is configured to exert a force directly or indirectly on the piston. This mechanism is only schematically shown in the figures and may be a loaded spring, for example as disclosed in US Pat. No. 4,447,225. According to another principle is the injection force generated by the gas under pressure. These two principles are well known in the art. The pressure in the pressure chamber during injection is on the order of 4000 psi (lbs per square inch).

When a single dose is delivered into the pressure barrel, the information about the delivered volume is applied from the liquid delivery unit to the control unit 28. The control unit first controls the pressurizing mechanism to move the pressure piston in the pressure barrel from the loaded position (FIG. 2A) to the sealed position (FIG. 2B). This movement is related to the volume that causes substantially all air to be released from the pressure vessel through the front end opening when the pressure piston 12 is in the sealed position. The pressurization mechanism then generates the force necessary to release the liquid through the shear opening, as required. This is shown as the forward movement of the plunger 17 with respect to the pressing mechanism 26.

2C and 2D show similar designs with slightly different layouts of rear control components. The dosing unit 24 has a dose setting button 25, which screws and rotates the rotational and / or axial displacement of the button 25 to administer the liquid through the conduit 22 into the pressure chamber 2. Any device known in the art can be used to convert it to forward movement of the pusher 19 for the storage piston 20, such as a nut device. FIG. 2C shows the instrument after this dose delivery has been made but prior to degassing. 2d shows the mechanism after degassing. Among the figures, the pressurizing mechanism 26 is adapted to control the dose setting unit 24 and the control unit 28 as can be seen with respect to the pressure chamber 2 and also from the different locations of the connections 29 therebetween. While moving forward with respect to the containing box, the plunger 17 does not move forward with respect to the pressing mechanism 26. The control mechanism is such that the button imparts a greater forward displacement of the pressurizing mechanism at the lower dose carrying movement and vice versa so that the outgassing forward movement of the pressurizing mechanism 26 is complementary to the dose volume delivered to the pressure chamber 2. Is placed. After degassing, the pressing mechanism can be pulled out to effect injection. The axial mobility of the pressurization mechanism by means of a fixed plunger facilitates the design of components such as springs and triggers, because it does not need to include any device for degassing.

At least a portion of the pressure chamber, the piston inside the pressure vessel and the conduit are preferably arranged as separate units which are disposable. The storage chamber, the pressurizing mechanism, the dosing unit and the control device are disposed in the housing. The separation unit and the housing are provided with corresponding fitting parts which allow the fluid connection to be formed through the conduit between the storage chamber and the pressure chamber and allow the unit to be detachably attached to the housing in a position such that the pressure mechanism acts on the piston. Equipped.

3a to 3e illustrate a syringe mechanism according to a second embodiment of the present invention.

3a to 3e show a cross-sectional view of a pressure chamber 4 having a shear opening 6 and a pressure chamber 2 comprising a piston 12 arranged inside the cylinder. The pressure chamber also includes a piston rod 30 and a rear support 36, with the central channel 32 of the piston rod connected to the needle 34. In addition, a bypass section 38 is further provided on the inner surface of the pressure cylinder where the piston is in its loaded position. Also shown in the figure is a portion of the storage chamber 16 with the membrane 18. The ram 40 (partially shown in the figure) is mechanically connected to a pressurizing mechanism (not shown), and forces the force generated by the pressurizing mechanism to the piston via the support 36 and the piston rod 30. Suitable for addition The ram is freely movable relative to the storage chamber. Preferably, the support 36 comprises a plurality of support arms (eg 3 to 5) at the proximal end of the piston rod. The support locates the needle in the central position of the pressure chamber and allows the needle to remain in a stable position as the needle passes through the thin film of the storage chamber. The support is also the support of the ram 40 when moving the piston rod and the piston in the distal direction.

Bypass section 38 may be arranged in many different ways. According to one preferred embodiment, multiple traces or channels for the liquid are provided on the inner surface of the pressure vessel. According to another embodiment, means are provided for causing deformation of the piston as it passes through the inner surface, thereby ensuring that the liquid passes through the piston. Many other variations of how to arrange the bypass section are known to those skilled in the art. 4A and 4B are cross-sectional views of a variant embodiment of the bypass section. According to this embodiment, the piston 12 has a plurality (eg 1 to 4) of channels 13. In the loading step of this method, the channel provides a fluid connection between the central channel 32 of the piston rod 30. In the sealing step, the piston rod 30 is liquid tightly coupled with the piston, thereby sealing the channel (FIG. 4B).

3A illustrates the loading step of this method. A predetermined single dose of liquid drug is released from the storage chamber by a dosage unit (not shown). A separation unit comprising a pressure chamber, a liquid conduit, a piston and a piston rod is disposed in connection with a housing (not shown). The upper part of the piston rod is provided with a sealing member 42, which is engaged with the inner surface of the pressure vessel in the loaded position to form a liquid tight coupling for the liquid conduit. The needle is inserted through the thin film 18 into the storage chamber. The dose is delivered from the storage chamber through the central channel of the needle and the piston rod and is passed into the pressure vessel 4 through the piston in the space between the distal end of the piston rod and the bypass section 38.

In the case where a predetermined volume has been carried into the pressure barrel, a control device (not shown) receives information from the dosing unit regarding the delivered volume and is a sealing step in which the piston is moved from the loaded position to the sealed position. To start.

3B shows the initiation of that step. The ram 40 presses the piston rod in the distal direction. The seal is broken from the piston and engaged with the inner surface of the pressure chamber to remain as a liquid tight seal. The piston rod comes in contact with the piston, which can seal the liquid conduit and push the piston out.

In FIG. 3C, the piston 12 is moved a predetermined distance to the sealed position by a ram exerting a force on the piston via the piston rod 30. The predetermined distance at which the piston is moved is related to the volume of one dose delivered into the pressure barrel, substantially all of the air is released through the front end opening 6 and the piston is connected to the bypass section 38. Is passed by. During the forward movement of the piston rod 30, the needle 34 is removed from the storage chamber fixedly placed relative to the pressure chamber 2. Syringe instruments are well known for performing infusion.

3d shows the end of the ejection step. A force is applied to the piston by the ram 40 via the piston rod 30 which presses the piston in the distal direction, thereby ejecting the liquid drug as a liquid jet through the front end opening. During this final forward movement of the piston rod, the needle 34 is completely removed from the storage chamber 2 and out of its sealing membrane 18.

In FIG. 3E, the ram 40 is removed from the support of the piston rod, and the separation unit (consisting of the piston rod with the pressure chamber, the pressure cylinder, the piston and the needle) is released from the housing (for example, threaded) and placed do. The needle is well protected by the pressure chamber when the separation unit is released. One important explanation is that the piston can be freely moved in relation to the piston rod. This prevents the piston rod from pulling the piston back in the proximal direction to the starting position, making it nearly impossible to reuse the instrument. Reuse should be avoided because of its inherent importance to minimize the risk of contamination or disease transmission. Another advantage with such a device is that there is no attachment and detachment between the piston and the piston rod in connection with the replacement of the disclosed disposable part. This feature is made possible in part by the fact that the present invention does not require the suction or withdraw of the liquid into the pressure chamber by the retraction of the piston, but the liquid can be reliably injected into the pressure chamber since degassing is carried out later. .

The storage chamber may be a single chamber in which a liquid drug is stored. The storage chamber may also be a two compartment (or multiple compartment) chamber with a bypass section (or bypass sections) for preparing liquid prior to injection.

Different storage chambers may be provided to accommodate different concentrations of liquid drug. It is advantageous to use a smaller input volume because it is less painful to inject a smaller volume than a larger volume. If a smaller injection volume is used, the concentration of the active substance in the liquid drug should be higher.

In the description of the present invention, the high pressure jet produced by the instrument is arranged to penetrate the skin of the patient. However, the basic principles of the present invention are equally applicable when performing needle injection of high viscosity liquid drugs such as gels. For example, if the gel is currently injected by a needle syringe, a needle of relatively large internal diameter should be used which is very painful. According to a variant embodiment of the invention, the hypodermic needle is attached in combination with the front end opening of the syringe instrument. This coupling is carried out in a strong manner to withstand the pressure in the pressure chamber during injection. Preferably, the needle is attached to the pressure chamber during the manufacture of the chamber, for example during the molding process. The injection procedure is the same as when performing a small jet injection with the needle as described above. By using a pressure chamber with a needle having an inner diameter similar to the opening of the front end of the pressure chamber, a high viscosity liquid can be injected using a needle that is thinner than before. This is very advantageous for patients suffering less. In particular according to a variant embodiment the necessary pressure required to carry out the needle injection depends on the inner diameter of the needle and the viscosity of the liquid gel.

Typical maximum pressures in the pressure chamber are generally at least 25 atm (2.5 MPa), often at least 50 atm (5 MPa) or at least 100 atm (10 MPa). Typically the pressure is below 1000 atm (100 MPa), often below 800 atm (80 MPa) or below 500 atm (50 MPa).

5 illustrates a multiple dose syringe instrument according to the present invention. The instrument includes an indicator 53 indicating the size of the dose, an adjustment control 55 for adjusting the single dose size, a mechanism 57 (controlling the dosing unit and the pressurizing mechanism) for preparing the infusion, the infusion And a housing 51 including a release trigger 59, a display window 61, and a detaching unit 63, which control the pressing mechanism for generating a force necessary for the purpose. 6 shows a separation unit 63 in a closed cover 65 with removable membrane 66 to maintain sterility. The separating unit 63 is suitable for detachably attaching to the housing when the injection is performed. The screws 67 and corresponding screws provided in the separation unit are arranged on the inner surface of the distal end of the housing. The unit 63 is unscrewed and discarded after use.

7A-7E illustrate mechanisms for administration, degassing and infusion as usable in the device embodiment of FIG. 3 corresponding to the anterior portion of these figures. The apparatus, collectively indicated at 700, includes a disposable part 701 and a reusable part 702 that houses the mechanism and the storage chamber. Disposable part 701 is provided with the same reference numerals as in FIG. 3 and includes a pressure chamber 2 having a pressure cylinder 4, a piston 12, and an opening 6, a central channel 32, and a rear needle ( 34) and a piston rod 30 having a support plate 36. The reusable component 702 includes a housing 710 surrounding the storage chamber 720 and the mechanism described later. The housing 710 has a front internal screw 711 for engaging an external screw on the disposable part 701 to remove the used disposable part and attach a new one, during which the needle 34 is held in a storage chamber thin film. Penetrates. Storage chamber 720, shown having a bottleneck front end, includes a through membrane 722, a storage piston 724, and an open rear end 726. The mechanism includes an injection unit 730 as best shown in FIG. 7F, which includes a front flange 732 and a spring 736 arranged to push in cooperation with the piston rod support 36. A ram sleeve 731 surrounding a storage chamber 720 having a rear flange 733 affected by it. The ram sleeve is telescopically disposed within the peripheral ram support 734 having a support flange 735 for the spring 736. The ram is axially movable relative to the ram support and the spring is biased to propel the ram forward with a force sufficient to produce the pressure required for injection, thereby also pushing the piston rod 30. Trigger button 737 is shown schematically and is arranged to lock ram 731 and ram support 734 normally with respect to each other, but allow forward movement of ram under the action of a spring when pushed. The entire injection unit 730 is arranged axially movable within the housing 710 to allow forward movement under the degassing step prior to the injection trigger, and the housing is externally accessible during this axial movement of the injection unit 730. A slit 712 is provided for adjusting possible trigger 737. The mechanism further includes a degassing unit 740 arranged to move the injection unit 730 forward during the degassing step, thereby also moving the piston rod 30 forward. The degassing unit 740 includes a transition element 741 that is axially movable, the transition element 741 having a front end 742 that cooperates with the ram support flange 735 when the injection unit is pushed forward. A rear push flange 743 cooperating with the pusher to be described, and a central hole 744 to allow axial passage freely around the central drum to be described. In addition, the mechanism is stored via the needle 34, the central channel 32 and the bypass section 38 to carry out liquid transfer from the storage chamber 720 into the pressure chamber 2 as described in connection with FIG. It may include a liquid conveying unit 750 disposed to displace the piston 724. The liquid conveying unit 750 includes a threaded plunger 751 disposed in a rotational direction that cooperates with a correspondingly threaded nut 752, which nut allows the rotation of the plunger to move the plunger in the axial direction. Axially and rotationally relative to The rear part of the plunger is inserted into and cooperates with the control drum to be described, which is inserted into a non-rotating coupling (not shown) such as a non-circular coupling so that the rotation of the drum imparts rotation on the plunger and the coupling In cooperation with the part, it is inserted into and cooperates with a one-way coupling (not shown) such as a detent and a gearwheel device such that the plunger is only rotated in one direction to move the plunger forward in the axial direction. The mechanism may also include a control unit 760 arranged to ensure continuous delivery of the predetermined dose volume from the storage chamber to the pressure chamber following degassing of the remaining volume of the pressure chamber. The control unit ensures these actions for single doses of different settings, ie shorter degassing strokes for many single dose volumes, such as longer degassing strokes for smaller one dose volumes. The control unit may comprise a drum 761 fixed axially but rotatably disposed relative to the housing. Except for the drum features already described for cooperation with the plunger 751, the drum includes a track 762 having a helical extension 763, a knee 764, and an axial straight extension 765. do. Around the axial circumference of the knee 764 is a rear push flange 743 of the transition element 741 prior to the degassing step. The control unit also includes a pusher 766 movably disposed in both axial and rotational directions relative to the housing, which pusher 766 is arranged to cooperate with the track 762 of the drum 761. Back screw cooperating with baluster 767, surface 768 cooperating with transition element 741, and correspondingly threaded portions of the dosage unit to be described, as well as external helical splines (not shown) on its outer surface. 769. When the pusher 766 is moved forward and locked to prevent rotation from a position similar to that shown in FIG. 7A, the drum first rotates due to the cooperation of the spiral track portion 763 and the follower 767, This rotates the plunger 751 so that the plunger is moved forward for the transport of the liquid from the storage chamber to the pressure chamber by the mechanism described above. When the follower reaches the track knee 764, the drum is no longer rotated and the transport of liquid is complete. In the knee, forward movement of the pusher will move the transition element and injection unit 730 forward in the degassing step. The pushers are arranged to execute the same forward stroke length for all injection cycles regardless of the starting position for the follower in the spiral of the track. Longer movement of the helical portion of the track imparts shorter movement in the straight track portion, and conversely, a desired relationship between dose delivery movement and degassing movement. Finally, the mechanism may include an action unit 770 for dose setting and pusher movement. The action unit includes a manually controlled knob 771, which can be rotated for dose setting and pushed for dose delivery and degassing. The knob has a screw 772 positioned to cooperate with the threaded portion of the pusher 766. Rotation of the knob will move the pusher to a selectable starting axial position corresponding to the desired dosage volume. Under this dose setting step, the pusher 766 is rotated with the follower 767 in the helical portion 763 of the track to prevent any rotation from being imparted on the control drum 761. This is controlled by the inner knob sleeve 774, which is fixed axially but fixed relative to the knob 771, and axially movable but for example by using a straight spline therebetween. Rotatable relative to the housing and having an outer helical spline (not shown) that cooperates with the outer helical spline on the pusher surface, the helical spline having a pitch corresponding to the pitch of the helical portion 763 of the track 762. And both pitches are not self-locking, while the pitch of the rear screw 769 is self-locking. After the dose setting has been made, the pusher is axially fixed relative to knob 771 and knob sleeve 774. The push action on the knob will move pusher 766 forward to perform the action described. A return spring 773 is arranged to bias the knob to its rear position, ie to move the knob back to its rear position under the reversal of the drum movement pattern which does not move the plunger 751 backward due to the one-way device described. There is no force acting to move the back 32. The stroke length for the knob must correspond to the maximum stroke length (arrow L) for the piston 12 in the pressure vessel 4 as shown in FIG. 7A. Preferably, the straight extension 765 of the track 762 should be at least the same length corresponding to the minimum dose and maximum degassing distance in the pressure chamber.

FIG. 7A shows the mechanism before any liquid is delivered but after the dose setting action to move the follower 767 to an intermediate position in the spiral track portion 763. In FIG. 7B, knob 771 is partially pressed to a position corresponding to full delivery of the selected dose volume. Preferably, the pushing is achieved by gripping the instrument housing and pressing it towards the support as shown in the figure, and preferably maintaining the dose delivered in the rear portion of the pressure barrel 4 with the instrument in an upright position. The height of the liquid shown is denoted D, and the air height is denoted L-D, as is the remaining stroke length for knob 771. In the position where the pusher 766 is shown, the follower 767 reaches the straight portion 765 of the track and is engaged with the transition element 741. Drum 761 is rotated (lower portion of spiral extension 763 is shown) to move plunger 751 and storage piston 724 forward. In FIG. 7C, the knob 771 is fully pressurized to the remaining distance L-D corresponding to full degassing of the pressure chamber 2. During this movement, the pusher 766 retains the remaining travel distance D relative to the piston 12 in the pressure chamber 2 and transfers the transition element 741, the injection unit 730 with the ram 731, the piston. The rod 30 and the piston 12 are displaced forward by a corresponding distance. Trigger 737 is moved forward in slit 712. During the same movement, the drum 761 does not spin and rotate because the follower is moved in the straight portion 765 of the track 762. Needle 34 has been moved away from the storage chamber as disclosed in more detail with respect to FIG. 3. In FIG. 7D, the knob 771 is detached and the return spring 773 moves the knob back to its extended position. Again, this inverts the movement of the pusher 766 and drum 761 in their original positions, but the plunger 751 and the storage piston 724 are not affected by the one-way device provided. In FIG. 7E, trigger 737 is operated to release ram 731 from ram support 734 such that spring 236 moves ram 731, piston rod 30 and piston 12 to their final forward position. Pressurizing to move the remaining distance (D). In the illustrated embodiment, the ram support 734 and the transition element 241 are springs (although they can be prevented from return movement by, for example, a ratchet device or a one-way mechanism, such as a detent and a gearwheel rail). Under the influence of 236, it is allowed to move backward to its original position. Injection is now complete and the disposable part 701 can be screwed away from the reusable part 702, the injection unit is ready again, and a new disposable part 701 is attached to repeat the cycle.

The disclosed apparatus illustrates a preferred embodiment in which a degassing mechanism is placed in series with the pressure mechanism and behind the pressure mechanism to move the pressure piston by moving the pressure mechanism. Several variations are possible. The degassing mechanism is in series but can be disposed between the pressure chamber and the pressurizing mechanism and is moved forward or with the pressurizing mechanism by stretching towards the fixed pressurizing mechanism. In addition, the degassing mechanisms can be arranged parallel to the pressing mechanisms so that they act completely independently of each other, in which case the pressing mechanisms are fixed or are pulled forward by the degassing mechanisms. In all variations, the degassing mechanism can move the pressure piston forward by stretching or moving relative to the housing, which movement can be accomplished by an actuation mechanism or by manual action, including the release of stored energy.

FIG. 8 schematically illustrates a prior art toothed rod, and FIGS. 9A-9D schematically depict a variant embodiment of the embodiment of FIG. 7 and are suitable for use in a toothed plunger rather than a screw screw and are pressurized It is suitable for both series and parallel configurations of mechanisms and degassing mechanisms. As shown in FIG. 8, by using a ratchet or ratchet system that can ride over a tooth in one direction but not in the other, it has a plurality of axially spaced dents or teeth 852. Injection or injection mechanisms for pushing the plunger 851 are known. The illustrated system has two fixed ratchets 853 to allow the plunger to move forward (upward in the figure) but not rearward (downward in the figure), the system as indicated by arrow 855. Two feeding ratchets 854 arranged for reciprocating movement, which, when equipped with a tooth, move the plungers together during forward movement rather than their rearward movement, the plungers being rearwarded by a fixed ratchet 853 Movement is prevented. According to a known variant, for example German Patent Publication No. 19900827, the tooth and / or ratchet can be slightly displaced axially in different circumferential portions of the plunger to correspond to the distance between two teeth on one side. To allow a smaller movement step.

9A and 9B show a plan view of a modified plunger 951 having a generally circular cross section and three axial gear sets 952 interposed with three axial flats 958 distributed around the plunger periphery, respectively. It is shown in the end view. All specific number of tooth sets may be used, for example at least one and up to five. As shown in FIG. 9A, the tooth is slightly inclined with respect to the plunger axis. Such plunger rods can be made from screws of suitable pitch with screws removed from the flats. As will be described further below, such a configuration may allow the ratchet to slide along the flat or engage the tooth according to its relative angular position.

In Figs. 9C and 9D, an apparatus similar to Fig. 7 is shown, the following description focusing on the differences. As described in connection with FIGS. 9A and 9B, the plunger 951 is centrally located within the mechanism shown and has the same purpose of transporting liquid from the storage chamber to the pressure chamber as described in connection with FIG. 7. The plunger 951 is axially movable relative to the housing 910 but locked in the rotational direction in all known ways, such as, for example, a component connected to a housing permanently keyed to the flat portion of the plunger. For a similar purpose described in connection with FIG. 8, a set of three fixed ratchets 953 are arranged to allow forward movement rather than rear of the plunger. These ratchets are permanently engaged with the plunger, but the device is preferably for example by allowing rotation of the plunger to release from both the fixed ratchet and the feeding ratchet when the knob is in its rear position or the knob in its pushed forward position. It may be present to allow release of the plunger retraction upon cartridge replacement by allowing rotation of the support for the fixed ratchet when in the. Similarly, three feeding ratchets 954 are disposed on the platform 955 which can be reciprocated and rotated axially enough to move the feeding ratchet to the gear engagement or flat portion shown. have. The platform 955 is coupled to the plunger driver 956 to move with the plunger driver in the axial direction but to rotate freely with respect to the plunger driver, for example by means of bearing attachments. Further described, the plunger driver is axle driven by a control knob having, in the illustrated embodiment, a gear wheel 957 that rotates between a fixed threaded housing rail 911 on the housing and a corresponding threaded knob rail on the control knob. Driven, this arrangement causes the plunger driver to be displaced at half the displacement of the control knob and to achieve a double pitch (axial step per turn) with reduced friction against the drum to be described. The spring 959 biases the plunger drive to the retracted position. In addition, the platform 955 is connected to the extension portion 967 of the drum 961, and rotation is imparted on the platform by the drum to feed the feeding ratchet 954 to the screw forming portion 952 and the plunger 951. While moving between the flat portions 958, the extensions can be freely moved axially with respect to the platform. These components may be parts of the control unit 960 with the same purpose as in the embodiment of FIG. 7, that is, to ensure the sequence of liquid conveying followed by degassing. In this embodiment, the drum 961 can be rotated as described to engage and disengage the ratchet 954 and the extension 967 is moved axially to affect a degassing unit (not shown). . The drum is preferably hollow to receive the plunger portion. The drum has a track 962, which track has a helical portion 963, a knee portion 964, and a first straight portion 965 and a second straight line connected to the spiral portion at the second knee portion 969. Part 966 is provided. The track cooperates with the track follower 968 attached to the housing in this embodiment. When the drum is moved in the axial direction, the track follower will ensure a first linear movement in the first straight portion 965 of the track, and the feeding ratchet 954 engages to push the plunger forward. When the follower 968 enters the track spiral 963, the follower imparts rotation on the platform 955 to separate the feeding ratchet from the plunger. Preferably, the pitch of the helical portion corresponds to the pitch of the inclined tooth 952 of the plunger, so that separation can be made without axial movement of the plunger. In this embodiment, the helical pitch is about twice the plunger tooth pitch due to the reduction in speed and movement in the gear wheel 957 system. However, it may have a larger pitch on the helical portion to form a liquid extraction during separation, for example to provide a constant volume of overdose independent of the dose set, such as to fill up useless space in the liquid delivery channel portion. Can be. Optionally, lowering the pitch may facilitate separation of the ratchet. The helical pitch should be unlocked even if it is possible to fine-tune the overall friction in the system, allowing locking to be achieved at high forces, for example to ensure that all overpressure is constant before the feeding ratchet is released. The pitch of the plunger tooth may be unlocked, but is preferably locked to set the plunger position. When the follower reaches the knee 964, the feeding ratchet is separated and further movement of the second straight portion 966 can be made without moving the plunger forward. As in the embodiment of Fig. 7, the knee portion 964 is in the position where degassing is initiated, and in this embodiment the shaft in a position where the extension 967 is in contact with the portion moving the piston in the pressure chamber. Direction. Further forward movement of the drum with the follower in the second straight portion 966 of the track will effect degassing by moving the piston in the pressure chamber. Since the follower movement in the helical portion 963 does not or only slightly displaces the plunger, the movement in the first straight portion 965 and the second straight portion 966 is complementary for the predetermined constant stroke length of the drum. Thus, a short movement in the first straight portion (a small liquid single dose) corresponds to a large movement in the second straight portion (long degassing) and vice versa. Dosage setting is controlled by the selection of the initial axial position of the drum. The operating unit 970 has a knob 971 which is controlled manually, which knob is connected to an axially displaceable portion 973 used for dose transport and degassing via a cooperating screw. And a rotatable portion 972 for the purpose. Rotation of the rotatable portion 972 moves the drum 961 to the initial axial position selected relative to the follower 968 in the first straight portion 965 of the track, which position corresponds to the desired dosage. . An axially displaceable portion 973 has an external threaded knob rail 974 associated with a gear wheel 957. Pushing the knob rotates the gear wheel and displaces the plunger driver 956 to move the plunger 951 for conveying the liquid. The displacement of the plunger driver will be half the displacement of the knob, which is suitable when the storage chamber has an internal cross section which is twice the internal cross section of the pressure chamber. In operation, the user first sets the dosage by rotating the rotatable portion 972. In FIG. 9C, the position of the follower 968 in the first straight portion 965 of the track corresponds to the minimum dose at which the follower is close to the helical portion 963 of the track. The feeding ratchet is engaged with the teeth 952 of the plunger 951. Next, knob 971 is pushed by the standardized stroke length for all doses to the position shown in FIG. 9D. During the movement of this first portion, the plunger is advanced to carry a small dose set by the cooperation of knob rail 974, gear wheel 957 and housing rail 911 to advance the plunger driver. When the follower has passed through the helical portion 963, the feeding ratchet 954 is separated from the plunger tooth by 60 ° rotation as shown in FIG. 9D (when using three sets of teeth), and the knee portion Further movement inward within the second straight portion 966 of the track with the followers of 964 serves for degassing purposes. In FIG. 9D, the follower 968 is in the bottom of the second straight portion of the track corresponding to the maximum degassing and maximum forward position for the extension 967 leaving the pressure chamber ready for injection. Upon removal of the knob, the spring 959 will press the knob 971, the plunger driver 956 and the drum 961 back to its original position with the extension 967. During this reverse movement, the plunger 951 is held fixed by the fixed ratchet 953, and the piston in the pressure chamber will remain in its ready position without being attached to the drive means.

The apparatus of FIG. 9 may be used with the remaining features of FIG. 7 not shown in FIG. 9, such as the same disposable pressure chamber portion and replaceable storage chamber portion. It is also possible to use the same kind of injection unit 730 and degassing unit 740, in which case the extension 967 of FIG. 9 basically acts as the transition element 741 of FIG. 7, ie in series form. And acts to move the entire injection unit assembly forward during the degassing step. Optionally, the embodiment of FIG. 9 can be combined with a device of parallel form, in which case the extension 967 acts independently on the piston rod support 36 during the degassing step and similarly the injection unit is injected Act independently on the piston rod support during the step. Such a device is shown schematically in FIG. 10.

FIG. 10 schematically shows a perspective view of a variant of the ram sleeve 731 of FIG. 7F, with the corresponding features being given the same reference numerals. The ram sleeve has a front flange 732 for maintenance of the storage chamber and for impingement on the piston rod support 36 during injection. It also has a rear flange 733 that is affected by a spring (not shown) that acts between the rear flange and the support (not shown), which support in this embodiment is not an entire injection unit but merely an injection unit. Since the ram sleeve is movable it can be fixed to the housing. Degassing rods 1001, 1001 'independently axially movable so as to slide relative to the ram sleeve and act independently with their front ends on the piston rod support for degassing purposes are partially cut in the ram sleeve. It is located in the department. Preferably, the two degassing rods are combined as shown by reference numeral 1002 to move integrally. This parallel device has several advantages over the serial device shown in FIG. During the degassing step, the degassing rams 1001, 1001 ′ form a distance between the piston rod support 36 and the flange 72 of the ram sleeve and create a through liquid starting high pressure that is followed by the lower support injection pressure. Although such a pressure profile is known, this example illustrates a possible implementation of the subject matter of the present invention. The stationary support for the ram sleeve can be manufactured simply and stably. The disclosed parallel device can be used with the embodiments described above. For example, the fixed support for the ram sleeve of FIG. 10 may replace the movable support 724 of FIG. 7, and the transition element 741 may be integral with the degassing ram 1001, 1001 ′ or the joint 1002. Can be replaced. Similarly, the apparatus of FIG. 10 may be used in the embodiment of FIG. 9 if, for example, extension 967 can be integrated or replaced with degassing ram 1001, 1001 ′ or joint 1002.

Preferably, the pressure chamber for use in the present invention is sterilized prior to assembly and is empty or filled with air or gas. Preferably, the pressure chamber is disposable but may be reusable. The inner diameter of the front end opening is 0.1 to 0.6 mm, preferably 0.15 mm. As mentioned above, the opening may be suitable for needleless injection or needle injection as schematically shown in the figures, in the case of needle injection the shear opening may have attachments or connectors for the needle. As is also known, short needles in the range of about 1 to 3 mm can be used to penetrate the outermost portion of the skin, thereby reducing the rate of ejection required to reach the target depth in the tissue.

Preferably the storage chamber is separate from the pressure chamber and is preferably made of a different material. According to a preferred embodiment the storage chamber is made of glass such as I-shaped glass and the pressure chamber is made of plastic such as polycarbonate.

According to a variant embodiment, the storage chamber is divided into two separate compartments by an intermediate piston, having a bypass section, the rear compartment of the two compartments containing a liquid, such as water, and the front compartment being lyophilized. Solid components such as powders. The liquid is pressurized into the end compartment via the bypass section so that the liquid dissolves the solid component. This is a method well known in the art of two compartment syringes. Thus, the mixed liquid located in the end compartment is conveyed into the pressure chamber in exactly the same manner as described above.

Bypass structures for use in pressure chambers or dual compartment storage chambers can take various forms. The bypass section shown generally includes one or more traces or bypass channels on the inner surface of the bypass section of the pressure chamber. The bypass channel can be parallel to the longitudinal direction of the discharge chamber, for example as disclosed in US Pat. No. 5,501,673. The number of channels is selected according to the amount of liquid to be conveyed, preferably 1 to 15 pieces. Many other different methods for arranging the bypass section are known in the art. It is important that not too many channels are disposed due to the volume of liquid remaining in the channel when the liquid is transported. It is also appropriate to reduce the unused volume held between all circumferential ridges on the piston by keeping the difference between the diameters through the ridges and through the main body of the pistons small. According to a variant embodiment, the inner surface of the bypass section is formed such that the piston deforms as it passes through the section, whereby a liquid from the storage chamber into the pressure chamber as disclosed, for example, in US Pat. Nos. 5,472,422 and 5,817,055. Allow to pass.

The different steps performed basically include a conveyance step in which liquid is transferred from the storage chamber into the pressure chamber, removal of air from the pressure chamber, and injection step. Preferably, the liquid conveying and degassing step is carried out very slowly and under low pressure as compared to the pressurizing step, so as not to induce liquid spray through glass breakage, plunger overflow or opening during bypass liquid foaming. Only the injection step is run under high pressure.

Both during the transport phase and during the air removal phase, the instrument is preferably held in a somewhat upright position to prevent liquid from spilling, ie the front end opening of the pressure chamber is horizontal, inclined or substantially forward.

The invention is not limited to the preferred embodiments described above. Various variations, modifications, and equivalents may be used. Accordingly, the above embodiments are not to be considered as limiting the scope of the invention as defined in the appended claims.

Claims (56)

An injector device for delivering liquid from a high pressure source, Ⓐ housing, A pressure chamber (2) comprising a pressure barrel (4) for receiving therein at least one piston and having a front end opening (6) for ejecting liquid and having sufficient strength to withstand liquid pressure Wow, Ⓒ the piston 12 inserted into the pressure cylinder, A storage chamber 16 for liquid or liquid precursor material components, separate from the pressure chamber, Ⓔ a conduit 22 between the pressure chamber and the storage chamber, In the syringe mechanism comprising a pressurizing mechanism 26 in the housing configured to exert a force directly or indirectly on a piston in the pressure barrel to create the liquid pressure. ① the pressure chamber, the piston, and at least a portion of the conduit are configured as a unit, The unit and the housing have a corresponding connecting portion, by means of which the unit is detachably attached to the housing, in fluid connection between the storage chamber and the pressure chamber via the conduit and a pressurizing mechanism acting on the piston Characterized in that Syringe apparatus. The method of claim 1, The piston in the pressure chamber is configured to move from the drug loading position where liquid drug is loaded from the storage chamber into the pressure chamber via the liquid conduit to a sealed position where the liquid conduit is closed. Syringe apparatus. The method of claim 2, Air inside the pressure chamber is released when the piston is in the sealed position Syringe apparatus. The method of claim 3, wherein And controlling the movement of the position from the loading position to the sealing position in accordance with the volume delivered from the storage chamber to the pressure chamber to allow substantially all air to be released from the pressure chamber. Syringe apparatus. The method according to any one of claims 1 to 4, The syringe mechanism further comprises a dosing unit configured to carry an adjustable volume of liquid from the storage chamber to the pressure chamber. Syringe apparatus. The method according to any one of claims 1 to 4, Characterized in that the volume of liquid drug stored in the storage chamber corresponds to a plurality of infusion doses. Syringe apparatus. The method according to any one of claims 1 to 4, The conduit consists of a bypass section which allows liquid to pass around the piston. Syringe apparatus. The method according to any one of claims 1 to 4, The storage chamber is in a fixed position with respect to the housing Syringe apparatus. The method according to any one of claims 1 to 4, The pressurizing mechanism acts on the piston through a piston rod in a pressure chamber that can be separated from the piston to form part of the conduit, the conduit comprising a needle attached to the piston rod and moving with the piston rod. By Syringe apparatus. The method of claim 9, The piston rod having a central channel for conveying liquid from the storage chamber to the pressure chamber Syringe apparatus. The method of claim 10, The piston rod comprises a needle having a channel connected with the central channel to penetrate the sealing membrane of the storage chamber Syringe apparatus. The method of claim 9, A distal end portion of the piston rod is provided with a sealing material made of elastic rubber which is engaged with the inner surface of the pressure vessel in the loaded position to achieve a liquid tight connection for liquid conduits. Syringe apparatus. The method according to any one of claims 1 to 4, The unit is characterized in that the disposable Syringe apparatus. A syringe unit configured to detachably attach to a syringe housing for discharging liquid from a high pressure source, the syringe unit comprising: A pressure chamber comprising a pressure passage for receiving at least one piston therein, a front end opening for ejecting liquid, the pressure chamber having a strength sufficient to withstand liquid pressure; A piston inserted into the pressure cylinder, Including a conduit between the pressure chamber and the storage chamber, The syringe unit is detachably attached to the housing such that it is fluidly connected between the storage chamber and the pressure chamber via the conduit and a pressurizing mechanism can be applied to the piston. Syringe unit. The method of claim 14, The pressurizing mechanism acts on the piston through a piston rod in a pressure chamber that can be separated from the piston to form part of the conduit, the conduit comprising a needle attached to the piston rod and moving with the piston rod. By Syringe unit. The method of claim 15, The piston rod having a central channel for conveying liquid from the storage chamber to the pressure chamber Syringe unit. The method of claim 16, The piston rod comprises a needle having a channel connected with the central channel to penetrate the sealing membrane of the storage chamber Syringe unit. The method of claim 17, A distal end portion of the piston rod is provided with a sealing material made of elastic rubber which is engaged with the inner surface of the pressure vessel in the loaded position to achieve a liquid tight connection for liquid conduits. Syringe unit. The method according to any one of claims 1 to 4, The connecting portion comprises corresponding screws and screws Syringe apparatus. The method according to any one of claims 1 to 4, Characterized in that the connection between the unit and the housing is made by a clamping connection Syringe apparatus. A method of preparing a syringe apparatus according to claim 1 for discharging liquid from a high pressure source, Encapsulating a liquid or liquid precursor substance component into a storage chamber, (B) conveying liquid from the storage chamber to a pressure chamber initially containing gas, the pressure chamber passing through a substantially constant cross section for accommodating at least one piston therein, the front end for ejecting liquid Said conveying step comprising an opening and having sufficient strength to withstand liquid pressure, C) pressurizing the pressure chamber by acting on a piston in the pressure barrel to create a liquid pressure; ① only partially filling the pressure chamber with liquid by conveying liquid from the storage chamber to the pressure chamber; (2) after the step (1), moving the piston forward with respect to the pressure chamber to substantially move the gas therein through the front end opening; ③ after the step ②, characterized in that it comprises the step of pressing the liquid in the pressure chamber to discharge the liquid through the opening How to prepare a syringe instrument. The method of claim 21, Mixing the components in the storage chamber before the step ① to produce a liquid How to prepare a syringe instrument. The method of claim 21 or 22, The force at step ③ is larger than the force at step ② How to prepare a syringe instrument. The method of claim 21 or 22, The pressure chamber is characterized in that initially substantially filled with gas How to prepare a syringe instrument. The method of claim 21 or 22, The pressurizing step is performed while holding the storage chamber stationary relative to the pressure chamber. How to prepare a syringe instrument. The method of claim 21 or 22, Wherein said conveying step comprises passing liquid past the piston. How to prepare a syringe instrument. The method of claim 26, The storage chamber comprises a storage vessel of substantially constant cross-section for receiving at least one storage piston therein, the passing step of conveying liquid by moving forward a second piston inserted into the storage vessel; Characterized in that it comprises How to prepare a syringe instrument. The method of claim 21 or 22, Characterized in that the conveying step ① and the moving step ② are executed sequentially during a single manual movement. How to prepare a syringe instrument. The method of claim 21 or 22, Dose setting step is preceded by the carrying step ① How to prepare a syringe instrument. An injector device for ejecting liquid from a high pressure source, Ⓐ housing, A pressure chamber (2) comprising a pressure cylinder (4) for receiving at least one piston therein, a front end opening (6) for ejecting liquid, and having a strength sufficient to withstand liquid pressure, Ⓒ the piston 12 inserted into the pressure cylinder, A storage chamber 16 for liquid or liquid precursor material components, separate from the pressure chamber, Ⓔ a conduit 22 between the pressure chamber and the storage chamber, In the syringe mechanism comprising a pressurizing mechanism 26 in the housing configured to exert a force directly or indirectly on a piston in the pressure barrel to create the liquid pressure. A liquid conveying unit arranged to move a liquid dose from the storage chamber to the pressure chamber via a conduit, (2) having a degassing mechanism configured to move the piston forward, directly or indirectly, and without the pressurizing mechanism triggered, at least to a stroke distance corresponding to a volume not occupied by the liquid dose of the pressure chamber; Characterized by Syringe apparatus. The method of claim 30, Characterized in that the degassing mechanism is arranged in parallel with the pressurizing mechanism Syringe apparatus. The method of claim 30, The degassing mechanism is arranged in series with the pressurizing mechanism Syringe apparatus. The method of claim 32, The degassing mechanism is arranged between the piston and the pressing mechanism Syringe apparatus. The method of claim 33, wherein The degassing mechanism is configured to move the piston by stretching between the piston and the pressurizing mechanism Syringe apparatus. The method of claim 31, wherein The degassing mechanism is arranged behind the pressing mechanism Syringe apparatus. 36. The method of claim 35 wherein The degassing mechanism is configured to move the piston by stretching between the housing and the pressurizing mechanism Syringe apparatus. The method of claim 36, The degassing mechanism is configured to move the piston forward by moving the pressure mechanism forward. Syringe apparatus. The method of claim 30, The degassing mechanism is configured to move the piston by activating stored energy Syringe apparatus. The method of claim 30, The degassing mechanism is characterized in that it is configured to move the piston by manual energy. Syringe apparatus. The method of claim 30, The pressurizing mechanism is configured to move the piston by activating the stored energy stored in the mechanical spring or pressurized gas. Syringe apparatus. The method of claim 30, Characterized in that the control device limits the piston stroke distance imparted by the degassing mechanism Syringe apparatus. 42. The method of claim 41 wherein Characterized in that the stroke distance is variable Syringe apparatus. The method of claim 42, Characterized in that the stroke distance varies as a function of the liquid dose moved into the pressure chamber. Syringe apparatus. The method of claim 43, The function is set to a stroke distance subtracted from the axial height D substantially from a constant distance L of the liquid dose when in the pressure chamber. Syringe apparatus. The method of claim 43, The control device is configured to be influenced by the liquid dosage volume for setting the variable stroke distance. Syringe apparatus. The method of claim 43, The control device is characterized in that it is designed to prevent the operation of the degassing mechanism until the carrying of the liquid dose is carried out. Syringe apparatus. delete delete delete The method of claim 30, The front end opening 14 is designed to form a liquid jet and is characterized by having short or subcutaneous needles of about 1 to 3 mm in length. Syringe apparatus. The method of claim 30, The front end opening is covered with a removable or rupturable closure or seal Syringe apparatus. The method of claim 30, The pressure chamber and the storage chamber are each made of different materials of plastic and glass Syringe apparatus. The method of claim 30, The storage chamber is a dual chamber storage chamber with a bypass section and at least one additional piston that divides the storage chamber into two small chambers. Syringe apparatus. The method of claim 30, The syringe mechanism has a larger space for the liquid in the storage chamber, not the pressure chamber, and is configured to be administered multiple times. Syringe apparatus. The method of claim 30, The pressure vessel has a rear liquid conveying position for the piston, in which the conduit is in pressure passing fluid communication in front of the piston, and the pressure vessel has a front sealing position for the piston, in which fluid communication Characterized by the absence of Syringe apparatus. The method of claim 55, A bypass device is present in the liquid conveying position to allow liquid to pass around the piston into the pressure chamber in front of the piston Syringe apparatus.

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