CN1507360A - Medical arrangement - Google Patents

Medical arrangement Download PDF

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Publication number
CN1507360A
CN1507360A CNA018098606A CN01809860A CN1507360A CN 1507360 A CN1507360 A CN 1507360A CN A018098606 A CNA018098606 A CN A018098606A CN 01809860 A CN01809860 A CN 01809860A CN 1507360 A CN1507360 A CN 1507360A
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CN
China
Prior art keywords
piston
pressure chamber
liquid
pressure
apotheca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA018098606A
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Chinese (zh)
Other versions
CN1255192C (en
Inventor
B��Ү��
B·耶特曼
��»���ķ
J·弗里德霍尔姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
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Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of CN1507360A publication Critical patent/CN1507360A/en
Application granted granted Critical
Publication of CN1255192C publication Critical patent/CN1255192C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Abstract

An injector device for delivery of liquid from a high pressure, the device comprising a housing, a pressure chamber 2 comprising a pressure barrel 4 for accommodation of at least one piston therein and having a front end opening 6 for ejection of the liquid, the pressure chamber being of sufficient strength to sustain the liquid pressure. The device further comprises a storage chamber 16, separate from the pressure chamber, for the liquid or the liquid precursor components, and a conduit 22 between the pressure chamber and the storage chamber. A pressurizing mechanism 26 in the housing is arranged to apply force, directly or indirectly, on the piston in the pressure barrel to create said liquid pressure. The pressure chamber, the piston and at least a part of the conduit is arranged as a unit, wherein said unit and the housing have corresponding fitting parts allowing releasable attachment of the unit to the housing in a position permitting fluid connection between storage chamber and pressure chamber through the conduit and permitting the pressurizing mechanism to act on the piston.

Description

Medical apparatus
Invention field
The present invention relates to as described in the preamble a kind of injection device, a kind of injecting unit and a kind of method of injecting with pressure chamber according to independent claims.
Background of invention
Principle of the present invention can be used for the syringe that high-pressure injection liquid is used in any requirement.Need discharge full-bodied product with high pressure, as oily, gel, pasty state, the product of amorphous (amorphism) or form of suspension, for example as dental use or in order to form the deposition of slow release in vivo.Another kind of to need to use highly compressed main syringe be the jet syringe that is used for liquid needleless transdermal that will pressurization, will further discuss below.Although for convenience's sake, the present invention uses this jet syringe to illustrate, the present invention can not be considered as being confined to this, and should be appreciated that and also comprise other high-voltage applications modes.
Using the injecting type injection device under sufficiently high pressure medicinal liquid to be carried out the injecting type injection to subcutaneous, penetrate the epidermis of human body or animal or mucosa and liquid is injected the tissue of epidermis or the following desired depth of mucosa, is the technology of knowing in the industry over several years.
U.S. Pat-2821981 has been announced a kind of multi-agent time injecting apparatus that uses ejector principle.In this known apparatus, liquid to be injected injects the pressure chamber of a distant place with the form of conventional syringe from a medicinal liquid chamber nearby, in the arrow-necked bottle.With a mechanism liquid of liquid chamber is transported to pressure chamber, another mechanism of reuse injects.Being provided with a check-valves in sprocket hole guarantees not reflux to occur.The complex structure of this injecting apparatus makes its manufacturing cost costliness.Another shortcoming of the apparatus of this mechanical mechanism complexity is to be difficult under the gnotobasis to assemble.Often require now to make those can contaminated parts in injection can not reuse (but disposal type, disposable).Described this class device of US-2821981, or this class device of every complicated in mechanical structure owing to the device of all being made up of a large amount of different parts, therefore are difficult to satisfy this requirement.
Described a kind of injection device of US-3138257 and US-2821981's is similar.
US-4447225 has described a kind of multi-agent time jet syringe, and medicine is input to the transfer chamber from medicine bottle or vial.By a check valve and a pipeline medicine is pumped to a drug infusion chamber again.This medicine is just prepared to have sprayed infusion then, by medicinal liquid being applied injection force it is discharged from the aperture of ejector.The shortcoming of the described jet syringe of US-4447225 is a complex structure, such as: before injection, medicinal liquid is carried out twice transfer, so its manufacturing cost height.
US-2591046 has described a kind of hypodermic syringe, has two chambers telling by by a bypass section.Medicinal liquid is input in the chamber of a distant place by the bypass section.There is not which independent cavity that different performances can be provided, as barotolerance.
The medicinal liquid that is used for injecting is injected and is stored in glass container as last adding syringe.Glass container is sealed by a rubber closure.Therefore medicinal liquid only directly contacts with glass and rubber.Is that plastics can not seal starvation fully and enter container or stop the one-tenth in the container to branch away without plastics as the main cause of medicine hold-up vessel.And some compositions will join in the plastics when making, and this can influence the liquid that is stored in the container.Another reason is the composition volatilization that plastics may make trace, is not allow this situation in injection is prepared.Above-mentionedly do the defective of containers for medical use, only be at using the conventional medicine storage life of plastic containers experience, as reach 2 years with plastics.When using the syringe that plastics do, medicinal liquid just contacts with plastics when injecting, so above-mentioned defective does not exist.
Making of glass in the jet injector of container, glass container must be able to bear from container and release the used high pressure of liquid.This glass container is preferably made of tempered glass, makes its costliness like this.On the contrary, plastics can provide pressure chamber necessary performance at an easy rate, as intensity and toughness and LB danger.But do apotheca and do pressure chamber with glass and be well suited for and do the disposal type disposable unit with plastics.
The object of the present invention is to provide a kind of manufacturing cost than the cheap and easy-to-use injection device of prior art.Another purpose of the present invention is to provide a kind of device, the defective of being mentioned above not having of build-up member under gnotobasis.Another purpose provides a kind of injection device, can be before injection medicine is added wherein earlier and stores a period of time, and it is aseptic that all surface that maybe will contact that this device contacts with medicine and parts thereof all can keep in production, storage and use.Also have a purpose to provide a kind of device, can be used for giving off multiple injection dosage from apotheca.Another purpose provides a kind of device in addition, and can change easily and be discarded in may contaminated parts in the injection.The present invention also has another purpose to provide a kind of device, have aseptic can not reusable parts, prevent unnecessary pollution, and the behavior that may jeopardize patient's the used device of reselling.A further object of the invention provides a kind of corresponding method from the high-voltage power supply infusion liquid.
Summary of the invention
Above-mentioned purpose is by according to the described a kind of injection device of the characteristic of independent claims, a kind of unit with a pressure chamber, and a kind of method of injecting realizes.
Dependent claims has been set forth preferred embodiment.
So, provide a kind of easy to use and make syringe simple, that have a small amount of movable part.This syringe can be used for any high-pressure injection to be used, and can add medicine in advance and store the effectiveness that wherein and not influences medicine, can also make under gnotobasis, preserves and use.
More preferably can be used for carrying out multiple injection according to injection device of the present invention.
It comprises a not re-usable discrete unit with a pressure chamber.After the use, be abandoned in used discrete unit, sets up new discrete unit when carrying out new injection on the shell of syringe.
According to a preferred embodiment of the present invention, liquid is pressed into pressure chamber from apotheca, rather than liquid is attracted to pressure chamber, and the employing sucking method can cause complex structure and be difficult to making.
According to another preferred embodiment of the present invention, a mechanism that separates with injection mechanism is responsible for the dosing of medicinal liquid.
The dosing unit offers control device with the information of the relevant dosage volume of carrying to pressure chamber by liquid-transport pipe-line from apotheca, and the control signal that produces electronic signal or mechanical movement form by control device is given pressure exerting arrangement then.The piston of this control signal controlled pressure chamber moves to and makes the position that does not retain air in the pressure chamber.
According to another preferred embodiment of the present invention, provide a utilization to rotatablely move and carry out the metering device of mechanical dosage.This motion is kept in the mechanism (or electronic memory) for the pressure exerting arrangement utilization.
Brief description
Figure 1A-1C is the sketch map of the different phase (step) of the method according to this invention.
What Fig. 2 A-2B illustrated is the injection device of first embodiment according to the invention, and what Fig. 2 C-2D illustrated is the control device of same device.
Fig. 3 A-3E signal be injection device according to second embodiment of the present invention.
Fig. 4 A-4B is the profile according to the selected embodiment of a bypass section of the present invention.
What Fig. 5 illustrated is according to multi-agent of the present invention time injection device.
Shown in Figure 6 is according to discrete unit of the present invention.
Fig. 7 A-7F signal be that of can cooperate the embodiment device of Fig. 3 to use is used for being provided with the dosage of batching, deaeration and the mechanism of injecting.
Fig. 8 is the sketch map of the toothed push rod of a prior art.
Fig. 9 A-9D cooperates the sketch map of the part of toothed push rod use through the embodiment of modification among Fig. 7.
Shown in Figure 10 is the modified push rod tube that is arranged in parallel.
The invention DETAILED DESCRIPTION OF THE PREFERRED
The corresponding techniques feature has identical numbering in institute's drawings attached.
The basic step of method of the present invention is shown in Figure 1A-1C.
A pressure chamber 2 comprises a pressure measuring cylinder 4, and it has the front aperture 6 and a hole 8 and the piston 12 that is inserted in pressure measuring cylinder hermetically that is used for receiving from the apotheca (not shown) medicinal liquid 10 that are used for injecting fluid.
Figure 1A is depicted as the dosing stage, and predetermined amount of liquid enters pressure measuring cylinder by hole 8.The volume that liquid enters is less than the volume of pressure measuring cylinder piston 12 tops.In this stage, piston is in the dosing position.Pressure chamber is positioned over position straight up, in conjunction with the surface tension of liquid, can prevent that the liquid of carrying into from overflowing from hole 6.As can be seen from the figure, hole 8 is located near position of piston, and liquid is upwards added from the bottom of pressure measuring cylinder, forces air to be discharged from hole 6.
Figure 1B is depicted as the airtight stage, and piston 12 moves on to closed position from the dosing position, will be communicated with hole 8 sealings of apotheca.The distance that piston moves is relevant with the volume of medicinal liquid, make when piston during in closed position all basically air from front aperture discharge pressure chamber.Situation as shown in the figure is the maximum liquid dosages that is delivered to pressure chamber.If dosage is less, piston will be in farther position certainly.
Fig. 1 C is depicted as injection stage, applies the power that is pressed to a distant place on piston, thereby medicinal liquid is ejected with liquid jet 14 by front aperture.
Fig. 2 A and 2B are depicted as the injection device according to the first embodiment of the present invention.
Be depicted as an injection device from the high-voltage power supply infusion liquid, it comprises a pressure chamber 2, and the latter comprises a pressure measuring cylinder 4, wherein accommodates at least one and is inserted in pressure piston 12 in the pressure measuring cylinder, also has a front aperture 6 that is used for drain 8.This pressure chamber has the sufficient intensity of the fluid pressure that can bear when injection, and preferably can abandon and made of plastic.
The apotheca 16 that separates with pressure chamber that this device also comprises a precursor component of depositing liquid or liquid.This apotheca is preferably made cylindrical shape with glass.One end of apotheca is provided with a closing membrane 18, and the other end then is inserted with a movably sealing storage piston.This closing membrane and piston are with the liquid sealing wherein.
Between pressure chamber and apotheca, be provided with a pipeline 22.This pipeline preferably with the integrally formed part of pressure chamber, and be provided with a syringe needle 23 with the passage that is connected with pipeline.Syringe needle 23 can penetrate the closing membrane 18 of apotheca, so that liquid can be connected between storage cylinder 8 and pressure measuring cylinder 4.
This device also comprises 24, one pressure exerting arrangements 26 in a dosing unit and a control unit 28.
This dosing unit 24 is suitable for the storage piston of apotheca is exerted pressure, so that carry the liquid of predetermined to pressure chamber by pipeline from apotheca.The volume of the liquid of being carried depend on store that piston moved apart from d.Shown in the dotted line is to store piston to move position that dosage reached of conveying.
Pressure exerting arrangement is to be used for the pressure piston of pressure measuring cylinder is exerted pressure, to produce fluid pressure.
This pressure exerting arrangement is directly or indirectly exerted oneself to piston.This mechanism just schematically illustrates in the drawings, and it can adopt as the described spring of US-4447225 and load.According to another kind of principle, injection force is produced by the gas of pressurization.This dual mode is what know in the industry.The pressure of pressure chamber when injection is 4000psi (pound/square inch).
After a dosage is transported to pressure measuring cylinder, offer control unit 28 from the liquid delivery section about the information of the volume carried.This control unit control pressure exerting arrangement makes pressure piston in its pressure measuring cylinder earlier, and (Fig. 2 A) moves to detent position (Fig. 2 B) from the dosing position.Its amount of movement is relevant with volume, so when pressure piston 12 during at detent position, all substantially air are all from front aperture discharge pressure tube.Then, this pressure exerting arrangement produces necessary pressure as required, and liquid is discharged from front aperture.Described in the drawings is piston rod 17 moving forward with respect to pressure exerting arrangement 26.
What Fig. 2 C and 2D illustrated is a similar design, and the configuration of the control unit at its rear portion is slightly different.Dosing unit 24 is equipped with a dosage setting knob 25, can make button 25 rotation and/or move axially the push rod 19 that promotes to store piston 20 with any known structure and move forward, such as with a screw and nut apparatus, the liquid of throwing in a dosage enters pressure chamber 2 by pipeline 22.Fig. 2 C shows that this device has been transfused to the liquid of a dosage, but deaeration not as yet.Fig. 2 D shows that this device discharges air.On these two figure, can obviously find out from the diverse location of the connector 29 between pressure exerting arrangement 26 and dosage metering device 24, pressure exerting arrangement 26 moves forward with respect to pressure chamber 2 and the casing that comprises dosing unit 24 and control unit 28, but piston rod 17 does not move forward with respect to pressure exerting arrangement 26.Carry motion for one of knob 25 less dosage, this controlling organization is arranged to make pressure exerting arrangement to do bigger moving forward, and vice versa, so the amount that the pressure exerting arrangement air-out moves forward becomes complementary relationship with the bolus volume of input pressure chamber 2.Just can cause after the pressure exerting arrangement air-out and inject.The structure of axially movable pressure exerting arrangement and fixed piston rod thereof makes this part be easy to design, for example uses a spring and a trigger, because do not need to comprise any device that is used for air-out.
At pressure chamber, the piston in the pressure measuring cylinder and at least section of tubing form the discrete unit that can abandon.Apotheca, pressure exerting arrangement, dosing unit and control device are arranged in the housing.
Unit that this is discrete and housing have corresponding assembly parts, and this discrete unit removably is connected on the housing, make that liquid can be communicated with by pipeline between apotheca and pressure chamber, and make pressure exerting arrangement can act on piston.
Fig. 3 A-3E signal be injection device according to second embodiment of the present invention.
Fig. 3 A-3E is the profile of pressure chamber 2, and this pressure chamber 2 comprises the pressure measuring cylinder 4 and the piston 12 that is inserted in the tube that are provided with a front aperture 6.This pressure chamber also comprises a piston rod 30, and the latter is provided with a central channel 32 that communicates with syringe needle 34 and a rear support 36.Inner surface at pressure measuring cylinder also is provided with a bypass section (by-pass portion) 38, and here, piston is in the dosing position.Can also see a part and the closing membrane 18 thereof of apotheca 16 in the drawings.Drift 40 (among the figure only display part) is connected with pressure exerting arrangement machinery (not shown), and is suitable for by bearing 36 and piston rod 30 power of pressure exerting arrangement generation being imposed on piston 12.This drift 40 can move freely with respect to apotheca.Bearing 36 preferably is provided with several support arms at the close end of piston rod, such as 3 to 5.This bearing is fixed on the centre position of pressure chamber with syringe needle and allows syringe needle keep its stable position when penetrating the closing membrane of apotheca.This bearing also is that drift 40 is used for bearing that piston rod and piston are moved to a distant place.
This bypass section 38 can be arranged to various ways.According to a preferred embodiment, be provided with several stria that circulates for liquid or grooves at the inner surface of pressure chamber.According to another embodiment, the surface is provided with the facility that can make the piston distortion when piston during by it within it, thereby guarantees that liquid can pass through piston.Skilled in the art will recognize that the replaceable mode of many kinds of bypass section designs.
Fig. 4 A and 4B have shown a kind of profile of alternative embodiment of bypass section.According to this embodiment, be provided with several grooves (passage) 13 in this piston 12, such as 1 to 4.In the dosing stage of injection, this groove can be communicated with central channel 32 fluids of piston rod 30.Be connected in that closing stage piston rod 30 and piston are airtight, thereby sealed these grooves (seeing Fig. 4 B).
Fig. 3 A has shown the dosing stage of this method.The medicinal liquid of a predetermined close is pushed from apotheca by dosing portion (not shown).This discrete unit comprises pressure chamber, fluid pipeline, and piston and piston rod, it is arranged to be connected with the housing (not shown).The top of piston rod is provided with a sealing member 42, its when the dosing position with the inner surface of pressure measuring cylinder match with fluid pipeline between form that liquid is close to be connected.Medicament flows through the space between piston rod far-end and piston and the bypass section 38 from the central channel of apotheca through syringe needle and piston, is transported in the pressure measuring cylinder 4.
After predetermined was delivered to pressure measuring cylinder, the control device (not shown) received from the dosing unit about the information of the volume of being carried and starts second stage that closing stage makes piston move on to detent position from the dosing position.
Fig. 3 B shows the beginning in this stage.Drift 40 promotes piston rod to a distant place.Formation liquid-tight seal that the sealing member of piston rod is pulled off from piston rod and maintenance matches with the inner surface of pressure chamber.This piston rod and then the sealing liquid pipeline and continue propelling piston of being connected with piston.
In Fig. 3 C, drift makes piston 12 move predetermined distance and arrives detent position by 30 pairs of piston application of forces of piston rod.The preset distance that piston moved is relevant with the dosage that is input to pressure measuring cylinder, make all basically air all pass through front aperture 6 and discharge, and piston has also moved through bypass section 38.When piston rod 30 moved forward, syringe needle 34 was extracted from apotheca, and the relative position of apotheca and pressure chamber immobilizes.
Fig. 3 D shows the end of injection stage.Drift 40 is pushed piston to a distant place by 30 pairs of piston application of forces of piston rod, thereby by front aperture medicinal liquid is ejected with liquid jet.When piston rod 30 moved forward at last, syringe needle 34 was extracted from apotheca 2 fully and is broken away from its closing membrane 18.
In Fig. 3 E, drift 40 detaches from the bearing of piston rod, and this discrete unit (piston rod by pressure chamber, pressure measuring cylinder, piston and band syringe needle is formed) just can be laid down (backing out) and abandon from housing.When this discrete unit of removal, syringe needle by intact protection in pressure chamber.
An important details is that the relative piston rod of piston is free active.In other words, piston rod can not be returned to piston and open the beginning position to direction nearby, make this device cannot be repeated to use.Why will avoid reusable reason is in order farthest to reduce the importance of pollution and disease propagation.Another advantage of this device is when changing described disposable unit, need not be connected and dismantle between piston and the piston rod.Why can have this characteristic to be because the present invention does not need liquid to be taken out or the inspiration pressure chamber by drawing back piston, but with malleation with liquid propelling pressure chamber, air is then discharged subsequently again.
Apotheca can be to have only a chamber that stores medicine separately.For prepare liquid before injection, it can be the chamber that the compartment of two (or a plurality of) is arranged also, and is provided with bypass section (or a plurality of bypass section).
Different apothecas is set stores different concentrated medicaments.It is favourable using small size dosage, because injection small size dosage painful little than large volume dosage.If use the small size injection, the concentration of the active substance in the medicinal liquid must be higher.
In to whole description of the present invention, produce the skin that high pressure jet stream penetrates the patient by this device.But ultimate principle of the present invention also can apply to use needle injection high viscosity medicinal liquid equally, as coagulant liquid.If use needle applicator injected gel liquid now, must use the bigger syringe needle of internal diameter, may make the patient very painful.Can select embodiment according to one of the present invention, a kind of hypodermic needle can be connected in the front aperture of this injection device.Pressure when injecting in order to resist in the pressure chamber must connect with very firm mode.This syringe needle preferably in making the pressure chamber process, such as: in molding process, connect with pressure chamber.Its injecting program is the same with above-mentioned needle-free jet injection.Employing is provided with the pressure chamber of the approaching syringe needle of the front aperture of internal diameter and pressure chamber, and full-bodied liquid just can be with injecting than thinner in the past syringe needle.This is very beneficial for reducing patient's pain sensation.Carry out depending on the viscosity of the internal diameter and the coagulant liquid of syringe needle according to the needed pressure of needle injection that should select embodiment.
The typical maximum pressure of pressure chamber is generally more than 25atm (2.5MPa), through the 50atm that is everlasting (5MPa) or more than the 100atm (10MPa).Usually its pressure is below 1000atm (100MPa), through the 800atm that is everlasting (80MPa) or below the 500atm (50MPa).
What Fig. 5 illustrated is according to multi-agent of the present invention time injection device.This device comprises housing 51, it has the indicator 53 of a dose indicating size, an adjustment control device 55 of adjusting dosage, a mechanism 57 that is used to prepare to inject (control dosing portion and pressure exerting arrangement), a control pressure exerting arrangement produces 59, one indicating windows of trigger 61 and this discrete unit 63 of the used motive force of injection.
Fig. 6 shows that this discrete unit 63 is housed in the cover 65, the protecting film of keeping aseptic cleaning that has one deck to tear off on the cover.In the time will injecting, discrete unit 63 removably is connected on the housing.Discrete unit is provided with screw thread 67, is provided with corresponding screw thread on the inner surface of housing far-end.Discrete unit 63 after the use can screw down and abandon.
Being one and being used to be provided with dosage of Fig. 7 A to 7E signal, the mechanism of air-out and injection, can with the device of embodiment shown in Figure 3, promptly corresponding front end component is used among the figure.Device 700 comprises that one can be abandoned part 701 and a reusable part 702 that comprises this mechanism and apotheca.Utilize Ref. No. identical among Fig. 3, this can be abandoned part 701 and comprise a pressure chamber 2 with pressure measuring cylinder 4, piston 12 and hole 6 and the piston rod 30 with central channel 32, back syringe needle 34 and bearing 36.This reusable part 702 comprises the housing 710 of an encirclement apotheca 720 and the mechanism that will further specify.This housing 710 has a female thread 711 with the front end that combines of external screw thread that can abandon part, can lay down used part and load onto new like this, and syringe needle 34 penetrates the closing membrane of apotheca in this replacing process.Apotheca 720 shown in the figure has an anterior bottleneck, comprises that one can allow 722, one of the closing membranes of needle pierces store piston 724 and a rear port 726.This mechanism comprises an injecting unit 730, and referring to Fig. 7 F, this injecting unit comprises a drift tube 731 around apotheca 720, and it has 732, one the back flanges 733 by spring 736 effects of front flange that are used to cooperate the bearing that promotes piston rod 36.This drift tube telescopically is arranged in the drift bearing 734 of a periphery, and drift bearing 734 is provided with the support lug 735 that cooperates spring 736.This drift can move axially with respect to the drift bearing, and spring is compressed so that drift is pushed away forward, so piston rod 30 is pushed away forward too, its strength enough produces the needed pressure of injection.Trigger button 737 schematic representation in the drawings, it is arranged to usually with drift 731 with towards bearing 734 states of locking mutually, but when pressing the button, drift moves forward under the spring pressure effect.Before starting injection, in the deaeration stage, whole injecting unit 730 can axially move in housing 710, and housing is provided with a triggering button 737 that adaptation exposes when injecting unit 730 moves axially and moves needed fluting 712.This mechanism also comprises an exhaust unit 740, discharges the stage at air, and injecting unit 730 is passed forward, and piston rod 30 is moved forward too.This exhaust unit 740 comprise one can axially movable adaptor 741, adaptor 741 has the front end 742 that the flange 735 that cooperates the pushing cylinder bearing pushes away injecting unit forward, also have the pusher flange 743 that cooperates the push rod that to describe in addition, and can allow a control that needs in addition to describe rouse the centre bore 744 that axially passes through therein.This mechanism comprises that also one can make and stores the transfusion unit 750 that piston 724 moves, as described in conjunction with Fig. 3, its effect be liquid from apotheca 720, through syringe needle 34, central channel 32 and bypass section 38 are input in the pressure chamber 2.This transfusion unit 750 comprises a rotatable threaded push rod 751, and its and nut 752 axial displacement non-rotatable with respect to housing with one matches, and 751 of push rods of rotation produce this push rod and move axially.The rear portion of push rod is with non-rotatable connected mode (not shown), such as non-circular connection, be inserted in the control drum (describing in addition) and and match with it, make the rotation of control drum pass to push rod 751, and utilize unidirectional connected mode (not shown), such as ratchet and ratchet means, push rod can only be rotated to move axially to previous crops towards a direction.This mechanism also comprises a control unit 760, is used for the dosage of predetermined is delivered to pressure chamber from apotheca, then the air of pressure chamber residual volume is discharged.Control unit can be finished different dosage settings with these actions, promptly carries out long instroke for low dose, then carries out short instroke for heavy dose.This control unit comprises a control drum 761, and it is arranged to maintain static vertically with respect to housing, but can be rotated.Except the feature of the control described drum, in order to cooperate with push rod 751, a conduit 762 is drawn together in this control bulge, and it has oblique section 76 3 of an oblique extension, and turning point 764 and one is the straight section 765 of extension vertically.Turning point 764 in axial position roughly in the position of pusher flange 743 before aerofluxus of adaptor 741.This control unit also comprise one can be with respect to housing rotation and the pushing cylinder 766 that axially moves, this pushing cylinder has is arranged to the conduit slide block 767 that matches with the conduit of controlling drum 761, the surface 768 of matching with adaptor 741, with the rear end screw thread 769 that the unitary corresponding threaded portion of the dosage setting of doing in addition to describe is matched, and the helical teeth groove (not shown) on the outer surface.When pushing cylinder 766 moves forward from the position shown in Fig. 7 A and during when spin locking, oblique section 763 of slide block 767 and conduit is matched, at first make control drum rotation, therefore drive push rod 751 rotations and move forward, utilize said mechanism that liquid is delivered to pressure chamber from apotheca.When slide block 767 arrives turning point 764, the no longer rotation of control drum, liquid is carried and is finished.In the turning point position, shoe surface 768 is connected with adaptor 741, and pushing cylinder further moves forward, and drives adaptor and injecting unit 730 and moves forward into exhaust phase.Pushing cylinder all can only move forward identical haul distance in the injection process each time, and is irrelevant in the original position of the oblique section of conduit with slide block.Long more oblique section of conduit mobile distance, just short more in the distance that the straight section of conduit moves, on the contrary then as the same, the required relation that this is given between the motion of delivered dose and air-out.At last, this mechanism also comprises an actuating unit 777 that carries out dosage setting and promote pushing cylinder.This actuating unit comprises the button 771 of a manpower control, and rotary knob can be set dosage, presses the button the then dosage and the air-out of delivery injection.Be provided with a screw that matches with the threaded portion of pushing cylinder 766 (screw rod) 772 in the button.Rotary knob can move to selectable initial axial location with pushing cylinder according to the volume of required dosage.At dosage be set this stage, be applied on the control drum 761, in slide block 767 oblique section 763 time, allow pushing cylinder 766 to rotate at conduit in order to prevent to rotate.This controls by button inner core 774, this button inner core 774 is motionless but can rotate relatively corresponding to button 771 axial restraints, yet then axially can relatively move corresponding to housing but can not rotate relatively, realize such as utilizing straight-tooth groove (key bar) between the two, this button inner core also has the outer helical teeth groove (not shown) that matches with the helical teeth groove on pushing cylinder surface, the pitch of its helical teeth groove is corresponding to oblique section 763 of conduit 762, and the pitch of these two helical teeth grooves can not make their self-lockings, and rear thread 769 is self-lockings.After the dosage setting, pushing cylinder is with respect to button 771 and 774 axial restraints.The promotion button moves forward pushing cylinder 766 and finishes described action.Back-moving spring 773 is arranged to button bias voltage backward is accompanied by the adverse movement of control drum, and button is brought back to back-end location, because described check configuration, push rod 751 will not return, so does not make it the effect of the power that moves backward on the piston rod 32.The row of button becomes length corresponding to the maximum length of stroke of piston 12 in pressure measuring cylinder 14, shown in the arrow line L among Fig. 7 A.And the length of the straight section 765 of conduit 762 is preferably at least corresponding to the minimum dose and the maximum aerofluxus distance of pressure chamber.
Fig. 7 A shows that this device is not transferred any liquid as yet, but has probably finished the dosage setting action, and slide block 767 is brought to the tiltedly centre position of section 763 of conduit.In Fig. 7 B, button 771 part is pressed into the position of all carrying corresponding to selected dosage volume.Preferably catch the housing of this device that button is pushed towards a supporter, as shown in FIG., and preferably this device is placed on position vertically upward, to allow the medicament carried remain on the rear portion of pressure measuring cylinder 4.The height of liquid is D as shown in the figure, and the remainder stroke length of air height and button 771 is L-D.In this position, the slide block 767 of pushing cylinder 766 arrives the straight section 765 of conduit and is connected with adaptor 741.Control drum 761 rotates (can see the bottom of oblique extension 763), drives push rod 751 and store piston 724 to move forward.In Fig. 7 C, button 771 was all pressed remaining distance L-D, corresponding to whole air of getting rid of pressure chamber 4.In this motion, pushing cylinder 766 makes adaptor 741, injecting unit 730 and drift 731, and piston rod 30 and piston 12 all move forward corresponding distance, and the move distance that piston 12 is stayed in pressure chamber 2 is D.Trigger 737 moves forward in groove 712.In this motor process, control drum 761 is stagnated, and does not also rotate, because slide block slides at the straight section 765 of conduit 762.Syringe needle 34 has been extracted out from apotheca, as described in abundant in conjunction with Fig. 3.In Fig. 7 D, release button 771, and back-moving spring 773 is return extended position with it.And while pushing cylinder 766 and control drum 761 also reverse the initial position of getting back to them, but push rod 751 and storage piston 724 are not affected owing to check configuration.In Fig. 7 E, pull trigger 737, drift 731 is discharged from drift bearing 734, make spring 236 act on 731, promote piston rod 30 and piston 12 until its last forward facing position, cover remaining stroke D.In embodiment as shown in the figure, drift bearing 734 and adaptor 741 can move back to initial position backward under the influence of spring 236, although also can avoid this answer to move, such as using catch pawl structure or unidirectional mechanism such as ratchet and tooth bar.At this moment, injection is finished, and droppable part 701 can screw down from spiral shell on the reusable part 702, and injecting unit recovers emission to be prepared, and changes the new part abandoned 701 to repeat next injecting program.
Described unit describe the exhaust gear series connection of preferred embodiment be arranged at the back of pressure mechanism, thereby move forward pressure piston by movement pressure mechanism.Also have several selectable schemes.This exhaust gear can also be connected and is arranged between pressure chamber and the pressure exerting arrangement, can travel forward by extending facing to fixed pressure exerting arrangement, also can move together with pressure exerting arrangement.This exhaust gear also can be provided with and independent fully mutually with pressure exerting arrangement parallel (parallel connection), and pressure exerting arrangement can be protected static or be deflated mechanism and pull to the place ahead like this.In all selection schemes, exhaust gear can move forward pressure piston by extending or moving with respect to housing, and starting these motions can comprise the actuating mechanism that discharges energy stored or with manually realizing with one.
Fig. 8 is the sketch map of the serrated rod of a prior art, Fig. 9 A-9D is the amended sketch map of embodiment process of Fig. 7, be used to cooperate toothed push rod rather than threaded push rod to use, toothed push rod is connected and is arranged in parallel mode and can be suitable for for pressure exerting arrangement and exhaust gear.As shown in Figure 8, what know is in syringe or injection device, to use ratchet or catch pawl system to advance push rod 851, the latter generally has a plurality of axial depression or double wedges 852 separately, and ratchet or catch pawl can be crossed over double wedge and move and can not move in the opposite direction towards a certain direction.Described system comprises two fixed catch pawls 853, can allow push rod move forward (towards the top of figure) but can not move (towards the below of figure) backward, also include two feeding catch pawls 854 that move back and forth as arrow 855 indications, this catch pawl drives push rod and moves when moving forward, but then cross over double wedge when mobile backward and do not drive push rod and move, catch pawl 853 restrictions that push rod then is fixed are not moved backward.According to existing variation, such as DE19900827, double wedge and/or catch pawl can axially slightly move on the different peripheral part of push rod, make push rod that the mobile stride littler than the distance between two double wedges of the same side can be arranged.The known structure of any of these can be used for described embodiment.
The end-view of the plane graph of Fig. 9 A and Fig. 9 B, demonstration be the push rod 951 of improved, it has one and basic is circular cross section and three groups of axial double wedges 952, the latter by three the axial plane parts 958 that are distributed in the push rod periphery at interval.The quantity of double wedge and planar section can be arbitrarily, such as at least one with up to 5.Shown in Fig. 9 A, double wedge has inclination slightly with respect to the axis of push rod.The screw thread that such push rod can utilize the threaded rod with suitable pitch to remove the planar portions office is made.To explain further that below this device makes catch pawl perhaps to be meshed with double wedge according to they relative positions, angle, perhaps slides along planar section.
What show in Fig. 9 C and 9D is the device similar to Fig. 7, and following introduction concentrates on its difference aspect.A push rod 951, as described in conjunction with Fig. 9 A and 9B, the center of mechanism shown in being arranged on, its effect with equally carry liquid to pressure chamber in conjunction with Fig. 7 is described from apotheca.Push rod 951 is arranged to move axially in any known mode but can not be rotated with respect to housing 910, such as the parts that utilize to be connected with housing, these parts permanently with the planar portions phase-splitting keyed jointing of push rod.For reaching the similar purpose of introducing in conjunction with Fig. 8, be provided with ternary fixedly catch pawl 953, push rod can only be moved forward can not be moved backward.These catch pawls and push rod are permanent engagement, although preferably providing a device that it is broken away from the push rod retraction when changing dressings bottle is connected, such as: when button falls back on back-end location, can allow push rod rotate, so that break away from fixedly catch pawl and feeding catch pawl, perhaps when button was in the position that is pressed forward, allowing fixedly, the bearing of catch pawl rotated.Similarly, 3 feeding catch pawls 954 are arranged on the platform 955, can either move back and forth vertically also and can fully rotate, and the feeding catch pawl is contacted with described double wedge engagement or with planar section.Platform 955 is such with the connected mode of a top rod driving device 956: it moves vertically with the top rod driving device, but can freely rotate with respect to the top rod driving device, such as: by the bearing-type connected mode.Further explain, the top rod driving device is driven vertically by a control knob and moves, in an illustrated embodiment, be by a gear 957, this gear rotates between the tooth bar corresponding on the housing tooth bar 911 that is fixed on the housing and the control knob, this device makes the top rod driving device obtain the pitch (the axial step pitch that circles) of half displacement of control knob and twice and has reduced controlling bulging friction, and this does explanation with other.A spring 595 is biased on the top rod driving device towards the direction of withdrawing.This platform 955 also is connected with the extension 967 of control drum 961, by this connection, the rotation of control drum is passed to platform, feeding catch pawl 954 is moved between the convex teeth portion 952 of push rod 951 and planar portions 958, but this extension can freely axially move with respect to platform.These parts are the part of control unit 960, and this control unit has identical purpose with the embodiment of Fig. 7, promptly facilitate liquid to carry afterwards this process of air-out again.In the present embodiment, control drum 961 both can rotate, and meshed or did not mesh with aforesaid feeding catch pawl 954, also can move axially to allow its extension 967 act on the exhaust unit (not shown).This control drum is for being matched with preferably hollow of push rod.This control drum is provided with a conduit 962, the latter have one tiltedly 964, one of 963, one turning points of section at second turning point 969 and oblique section 963 first straight section 965 that is connected and one second straight sections 966.This conduit cooperates with a conduit slide block 968, and this slide block is connected on the housing in this embodiment.When control drum moved axially, the conduit slide block moved along first straight section 965 of conduit, and feeding catch pawl 954 is connected with push rod push rod is upwards pushed away.When slide block enters oblique section 963 of conduit, rotation is passed to platform 955, the feeding catch pawl is broken away from push rod be connected.Tiltedly the pitch of section preferably adapts with the pitch of the inclination double wedge 952 of push rod, so that break away from when connecting push rod is moved axially.In the present embodiment, because gear 957 systems have reduced speed and displacement, tiltedly the pitch of section is the twice of about push rod double wedge pitch.Yet, also can allow oblique section part have slightly high any pitch, make and fluid seepage can take place when connecting breaking away from, such as, the dosage that exceeds the quata of administration of fixed amount outside the dosage of setting, be used for for example filling up the dead angle of liquid-transport pipe-line part.Changed, and adopted less pitch can help discharging catch pawl.Tiltedly the pitch of section part should be non-locking, although friction that also can the fine tuning whole system make under bigger counteracting force, locking can occur, such as can guarantee must any overvoltage of balance before being discharged into to catch pawl.The pitch of push rod double wedge can be non-locking but preferably locking, to guarantee the position stability of push rod.When slide block arrived turning point 964, the feeding catch pawl broke away from and connects, and it further moves along second straight section 966, and push rod is moved forward.As in the embodiment of Fig. 7, turning point 964 position in the axial direction is the starting position of exhaust phase just, and in the present embodiment, this moment, extension 967 just contacted the parts that the piston that makes pressure chamber moves.Control drum further moves forward, and slide block is passed piston forward in pressure chamber and to be carried out aerofluxus then along second straight section 966 of conduit forward.Because slide block can not moving of the oblique section 963 of conduit, perhaps just a little, push rod is moved, so, slide block is complementary in the given haul distance that moves for the control drum of first straight section 965 and second straight section 966, so mobile (the little liquid dosages) of the weak point in first straight section corresponding to move (long exhaust process) of the length in second straight section, vice versa.The dosage setting is to control by the axial initial position of selecting the control drum.An actuating unit 970 comprises the button 971 of a manual control, and it has a rotary part 972 that dosage is set, by the screw thread that matches be used for delivered dose and be connected with deflated axially-displaceable dynamic component 973.Rotate 972 of rotary parts and drive 961 to selected initial axial locations of control drum, correspondingly, slide block 968 moves in first straight section 965 of conduit, and this position is corresponding to desired dosage.Axially movable part 973 has the outer tooth bar 974 of the button that is meshed with gear 957.Press the button, gear is rotated and mobile top rod driving device 956, drive push rod 951 and carry liquid.The displacement of top rod driving device is half of button displacement, the situation when just in time being suitable for interior area of section when apotheca and being the twice of interior area of section of pressure chamber.In operating process, user at first is provided with dosage by rotating rotating part 972.In Fig. 9 C, slide block 968 is arranged in first straight section 965 of conduit, slide block near oblique section 963 of conduit corresponding to a minimum dose.Double wedge 952 engagements on feeding catch pawl and the push rod 951.Press the button 971 then and finish the standard haul distance of importing all dosage, arrive the position shown in Fig. 9 D.In this first that moves, the cooperation by button tooth bar 974, gear 957 and housing tooth bar 911 makes the reach of top rod driving device, moves forward push rod, to carry set low dose of liquid.When slide block during by oblique section 963, feeding catch pawl 954 rotates 60 degree (when using three groups of double wedges) and breaks away from push rod and is connected, and shown in Fig. 9 D, control is roused and is moved further, and slide block enters second straight section 966 of conduit, realization aerofluxus purpose from turning point 964.In Fig. 9 D, slide block 968, makes pressure chamber perform injection and prepares corresponding to maximum aerofluxus and position the most forward, extension 967 in the extreme lower position of second straight section of conduit.During release button, spring 959 forces button 971, top rod driving device 956 and control drum 961 and extension 967 thereof to get back to its initial position.Return in the moving process at this, push rod 965 catch pawl 953 that is fixed is maintained fixed, and the piston in the pressure chamber is then stayed its ready position, is not connected with its driving device.
Other features of Fig. 7 that the device of Fig. 9 can not show in Fig. 9 are used, such as: the identical pressure chamber abandoned part and removable apotheca part.Can also use identical injecting unit 730 and exhaust unit 740, in fact the effect of the extension 967 of Fig. 9 is equivalent to the adaptor 741 of Fig. 7 like this, promptly at exhaust phase the injecting unit of whole series-mode frame is moved forward together.In addition, the embodiment of Fig. 9 also can be incorporated into the block form structure, and wherein extension 967 acts on piston rod bearing 36 separately at exhaust phase, and injecting unit is to act on the piston rod bearing separately at injection stage too.This structure is anticipated as shown in Figure 10.
Figure 10 shows be drift tube 731 among Fig. 7 F through amended schematic perspective view, corresponding feature gives identical Ref. No..This drift tube is located at the periphery of apotheca, and it has a front flange 732, is used to keep apotheca and impact piston rod bearing 36 when injection.Also has a back flange 733 by the effect of spring (not shown), spring acts between this back flange and a support seat (not shown), and in this embodiment, this supports seat can be fixed in housing, because have only this drift tube, rather than whole injecting unit is active.But be provided with two active air exhaust rod 1001 and 1001 ' of discrete axial in the grooving of drift tube, they can slide with respect to the drift tube, and its front end acts on the piston rod bearing independently and carries out aerofluxus.For same moved further, these two air exhaust rod preferably connect together, as shown in 1002 places.The structure of this parallel connection has some advantages than cascaded structure shown in Figure 7.At exhaust phase, air exhaust rod 1001 and 1001 ' makes between piston rod bearing 36 and the drift tube front flange 732 and has produced distance, can produce higher liquid with lower continuous injection pressure and penetrate pressure.Although known a kind of pressure distribution also is such, this embodiment holds itself out to be in the cards in this article.The fixing support seat of drift tube can be done simply and be stable.Described parallel construction can be used together with the foregoing description.For instance, the hold-down support structure of the drift tube of Figure 10 can replace the active bearing 734 among Fig. 7, adaptor 741 can with air exhaust rod 1001 and 1001 ' or joint 1002 integral body link together or replaced by them.Similarly, the structure of Figure 10 also can be used together in conjunction with the embodiment of Fig. 9, such as, extension 967 can with air exhaust rod 1001 and 1001 ' or joint 1002 integral body link together or replaced by them.
Be used for pressure chamber of the present invention preferably sterilization earlier before assembling, empty or be full of air or other gas.They are preferably disposable, but also can reuse.The internal diameter of front aperture is 0.1-0.6mm, preferably about 0.15mm.As mentioned above, this hole both can be used for the injection of Needleless jet formula, as shown in drawings, also can be used for needle injection, and front aperture just is provided with connecting portion or the adapter that connects syringe needle like this.The hour hand head of existing known about 1-3mm can be used for the top layer part of transdermal, reaches the following necessary jet velocity of target depth of tissue thereby reduce.
Apotheca preferably separates with pressure chamber, and the most handy different material manufacture.According to a preferred embodiment, apotheca is made by glass, and such as I class (Type I) glass, pressure chamber is made by plastics, such as Merlon.
According to another alternate embodiments, this apotheca is separated by an intermediate piston becomes two independently compartments, and is provided with the bypass section, and the compartment of back contains liquid, such as water, is placed with solid constituent in the compartment of front, such as lyophilized powder.The liquid pressurized enters the compartment of far-end by the bypass section, and liquid dissolves solid constituent there.The syringe of this pair of compartment is a technology well known in the art.Then, the mixing material in the far-end compartment is just to be transported in the pressure chamber with the identical mode of said method.
Be used for the pressure chamber or the bypass of two compartment stores chamber design, various ways can be arranged.Shown bypass section (bypass segment) comprises one or more grooves that are arranged on pressure chamber bypass section inner surface, i.e. bypass slot basically.This bypass slot can be the parallel longitudinal with conveying chamber, described in US5501673.They also can be arranged to vertically have a certain degree with it, described in US5716338.The quantity of groove depends on the amount of the liquid that will carry, preferably is approximately 1 to 15.From prior art, also know many other different bypass section set-up modes.Importantly because liquid when carrying, can stay liquid, so the too many groove of quantity is not set in groove.For being suitable for reducing the dead angle (wasted space) between the piston periphery surface oncus, by the diameter at oncus place and by keeping less gap between the diameter of piston only.According to another alternate embodiments, the shape of bypass section inner surface produces distortion when making piston through it, thereby allows liquid flow to pressure chamber from apotheca, as: US5472422 and US5817055 are described.
The different step of being carried out is the three phases process basically, comprises that one is transported to transfusion stage of pressure chamber from apotheca, a stage and the injection stage that air is discharged from pressure chamber with liquid.Transfusion stage and exhaust phase preferably carry out rather slowly being compared under the low pressure in the stage of exerting pressure, and do not cause that glass breakage, push rod break through bypass section, liquid and bubble or penetrate from the hole.Have only injection stage just need under high pressure carry out.
All preferably this device is placed on relative position vertically upward in the transfusion stage with exhaust phase, promptly the front aperture of pressure chamber exceeds horizontal level, tilts or, can avoid liquid to flow out substantially up.
The present invention is not limited in above-mentioned preferred embodiment.Various replacements improve and equivalent can adopt.So the foregoing description is not to be used as limiting the scope of the invention, the present invention is defined by appended claim.

Claims (56)

1. one kind is used for from the injection device of high-voltage power supply infusion liquid, and this device comprises:
A) housing,
B) pressure chamber (2), it comprises a pressure measuring cylinder (4), and this pressure measuring cylinder is used to accommodate at least one piston and has the front aperture (6) that a drain is used, and this pressure chamber has the sufficient intensity that bears fluid pressure,
C) piston (12) that is inserted in the pressure measuring cylinder,
D) apotheca (16) that separates with pressure chamber, it is used for the precursor component of storaging liquid or liquid,
E) conduit (22) between pressure chamber and apotheca,
F) pressure exerting arrangement (26) that is arranged in the housing, it is used for the piston of pressure chamber is applied power directly or indirectly, with the generation fluid pressure,
It is characterized in that its improvement comprises:
I) this pressure chamber, piston and at least a portion conduit are formed a unit, and
Ii) this unit and this housing have corresponding build-up member, make this unit removably and housing connect into to allow and form fluid connection by conduit between apotheca and the pressure chamber, and allow pressure exerting arrangement can act on piston.
2. according to the injection device of claim 1, it is characterized in that the piston in this pressure chamber can be from a dosing position, promptly medicinal liquid moves to a detent position, i.e. the pent position of liquid conduits from the position of apotheca through liquid conduits adding pressure chamber.
3. according to the injection device of claim 2, it is characterized in that piston is when detent position, the air in the pressure chamber is discharged from.
4. according to the injection device of claim 3, it is characterized in that, this device also comprises a control device, and this control device moves to detent position according to the volume control piston that is transported to pressure chamber from apotheca from the dosing position, so that all substantially air are all discharged from pressure chamber.
5. any one injection device in requiring according to aforesaid right is characterized in that this device also comprises a dosing unit, and this dosing unit is arranged for an adjustable liquid volume is transported to pressure chamber from apotheca.
6. any one injection device in requiring according to aforesaid right is characterized in that the medicine liquid volume that is stored in the apotheca is the dosage of multiple injection.
7. any one injection device in requiring according to aforesaid right is characterized in that this conduit comprises a bypass section, and liquid can be passed through around piston.
8. any one injection device in requiring according to aforesaid right is characterized in that this apotheca is arranged on respect to the fixed position of housing.
9. any one injection device in requiring according to aforesaid right, it is characterized in that pressure exerting arrangement acts on piston by a piston rod, this piston rod can separate with piston, to form catheter segment, be provided with one in the conduit and link to each other with piston rod so that the syringe needle of Yi Donging together.
10. according to the injection device of claim 9, it is characterized in that this piston rod is provided with a central channel from apotheca to pressure chamber that carry liquid from.
11. the injection device according to claim 10 is characterized in that, this piston rod is provided with a syringe needle, and this syringe needle has the pipeline that is connected with described central channel, is used to pierce through the closing membrane of apotheca.
12. according to any one injection device in the claim 9 to 11, it is characterized in that, the distal portions of this piston rod is provided with a closure member, this closure member is preferably made with elastic rubber material, when the dosing position, be connected, so that liquid conduits obtains the close connection of liquid with the inner surface of pressure measuring cylinder.
13. any one injection device as in the above-mentioned claim it is characterized in that, but this discrete unit is a disposal type.
14. one kind removably is connected in an injector housing and is used for from the syringe unit of high-voltage power supply infusion liquid, this unit comprises:
-one pressure chamber, it has a pressure measuring cylinder, and this pressure measuring cylinder is used to accommodate at least one piston and has the front aperture that a drain is used, and this pressure chamber has the sufficient intensity that bears fluid pressure,
-one be inserted in the pressure measuring cylinder piston and
-one conduit between pressure chamber and apotheca when it is detachably connected on the housing when in place, can allow form fluid connection by conduit between apotheca and the pressure chamber, and allow pressure exerting arrangement can act on piston.
15. syringe unit according to claim 14, it is characterized in that, this pressure exerting arrangement acts on piston by a piston rod in the pressure chamber, and this piston rod can separate forming catheter segment with piston, and this conduit is provided with one and links to each other so that the syringe needle that moves with piston rod.
16. the syringe unit according to claim 15 is characterized in that, is provided with a centre bore in this piston rod, is used for carrying liquid from apotheca to pressure chamber.
17. the syringe unit according to claim 16 is characterized in that, this piston rod is provided with a syringe needle, and this syringe needle has the pipeline that is communicated with described centre bore, is used to pierce through the closing membrane of apotheca.
18. syringe unit according to claim 17, it is characterized in that the distal portions of piston rod is provided with a closure member, this closure member is preferably made with elastic rubber material, when the dosing position, be connected, so that liquid conduits obtains the close connection of liquid with the inner surface of pressure measuring cylinder.
19., it is characterized in that this build-up member comprises the screw rod and the screw thread of mutual correspondence according to any one injection device of claim 1 to 13 or according to any one syringe unit of claim 14 to 18.
20., it is characterized in that the assembling between this unit and the housing connects by clamping to connect and realizes according to any one injection device of claim 1 to 13 or according to any one syringe unit of claim 14 to 18.
21. the method from the high-voltage power supply infusion liquid, the method comprising the steps of:
A) precursor component with liquid or liquid is enclosed in the apotheca,
B) liquid is transported to the pressure chamber that contains gas at first from apotheca, this pressure chamber has a substantially invariable pressure measuring cylinder of cross section, this pressure measuring cylinder is used to accommodate at least one piston and has a front aperture that is used for drain, this pressure chamber has the sufficient intensity that can bear fluid pressure, and
C) the piston action power in pressure chamber is exerted pressure to pressure chamber, to produce fluid pressure, it is characterized in that its improvement comprises step:
I) carry liquid from apotheca to pressure chamber, only make partly full of liquid of pressure chamber,
Ii) in step I) afterwards piston with respect to pressure chamber move forward until basically wherein gas from front aperture discharge and
Iii) at step I i) afterwards the liquid in the pressure chamber is exerted pressure, so that liquid is discharged from front aperture.
22. a kind of method according to claim 21 is characterized in that, in step I) before various compositions are mixed in apotheca, to make this liquid.
23. any one method according to claim 21 to 22 is characterized in that, is higher than at step I i in the power that step I is ii) acted on) in.
24. any one method according to claim 21 to 23 is characterized in that, this pressure chamber has been full of gas basically when initial.
25. any one method according to claim 21 to 24 is characterized in that, when the step of exerting pressure is carried out, makes apotheca keep static with respect to pressure chamber.
26. any one method according to claim 21 to 25 is characterized in that, comprises in the supplying step making the step of liquid by piston.
27. method according to claim 26, it is characterized in that, this apotheca comprises the storage cylinder of a cross section substantial constant, at least one is housed in this storage cylinder stores piston, should comprise by step moving forward one second step that piston moves liquid that is inserted in the storage cylinder.
28. any one method according to claim 21 to 27 is characterized in that, supplying step (i) and mobile step are (ii) finished in proper order by a single artificial sport.
29. any one method according to claim 21 to 28 is characterized in that, supplying step (i) has a dosage that step is set before.
30. one kind is used for from the injection device of high-voltage power supply infusion liquid, this device comprises:
A) housing,
B) pressure chamber (2), it comprises a pressure measuring cylinder (4), and this pressure measuring cylinder is used to accommodate at least one piston and has the front aperture (6) that a drain is used, and this pressure chamber has the sufficient intensity that bears fluid pressure,
C) piston (12) that is inserted in the pressure measuring cylinder,
D) apotheca (16) that separates with pressure chamber, it is used for the precursor component of storaging liquid or liquid,
E) conduit (22) between pressure chamber and apotheca,
F) pressure exerting arrangement (26) that is arranged in the housing, it is used for, and the piston to pressure chamber applies power directly or indirectly when triggering, with the generation fluid pressure,
It is characterized in that its improvement comprises:
I) transfusion unit, it is arranged for liquid is transported to pressure chamber from apotheca through conduit, and
Ii) exhaust gear, it is arranged to and the pressure exerting arrangement that is not triggered makes piston forward move one corresponding to the volumetrical stroke distances that is not occupied by liquid dosages in the pressure chamber together directly or indirectly.
31. the device according to claim 30 is characterized in that, this exhaust gear and pressure exerting arrangement are arranged in parallel.
32. the device according to claim 30 is characterized in that, this exhaust gear and pressure exerting arrangement are arranged in series.
33. the device according to claim 32 is characterized in that, this exhaust gear is arranged between piston and the pressure exerting arrangement.
34. the device according to claim 33 is characterized in that, this exhaust gear is arranged to come mobile piston by elongation between piston and pressure exerting arrangement.
35. the device according to claim 31 is characterized in that, this exhaust gear is arranged on the pressure exerting arrangement back.
36. the device according to claim 35 is characterized in that, this exhaust gear is arranged to come mobile piston by elongation between housing and pressure exerting arrangement.
37. the device according to claim 36 is characterized in that, this exhaust gear is arranged to come mobile piston by promoting pressure exerting arrangement forward.
38. the device according to claim 30 is characterized in that, this exhaust gear is arranged to the mobile piston that is used for by stored energy.
39. the device according to claim 30 is characterized in that, this exhaust gear is arranged to the mobile piston that is used for by manpower.
40. the device according to claim 30 is characterized in that, this pressure exerting arrangement is arranged to by stored energy, such as the mobile piston that is used for that is stored in energy in mechanical spring or the pressed gas.
41. the device according to claim 30 is characterized in that, a control device defines the stroke distances that exhaust gear passes to piston.
42. the device according to claim 41 is characterized in that, the trip distance is variable.
43. the device according to claim 42 is characterized in that, the trip distance becomes as the function that is input to the liquid dosages of pressure chamber.
44. the device according to claim 43 is characterized in that, this function is set at a constant length (L) substantially with the trip distance and deducts the axial height (D) of liquid dosages in pressure chamber the time.
45. the device according to claim 43 is characterized in that, this control device is arranged to the stroke distances variable according to the volume settings of liquid dosages.
46. the device according to claim 43 is characterized in that, this control device is designed to stop exhaust gear to start before the liquid dosages conveying finishes.
47. the device according to claim 42 is characterized in that, the variation of the trip distance is that after stall, this element moves forward piston directly or indirectly by the stall that changes an element (dead run).
48. the device according to claim 47 is characterized in that, this element makes transfusion unit carry liquid dosages during being arranged in stall.
49. the device according to claim 48 is characterized in that, this element is arranged to carry out substantially the same total motion, and irrelevant with the variation of stall setting.
50. the device according to claim 30 is characterized in that, hour hand head or hypodermic needle that this front aperture (14) is designed to cooperate a kind of length to be about 1 to 3 millimeter are used to form liquid jet.
51. the device according to claim 30 is characterized in that, is coated with one deck on this front aperture and can tears sealing or closure member of maybe can staving off.
52. the device according to claim 30 is characterized in that, this pressure chamber and apotheca are made with different materials, preferably make with plastic and glass respectively.
53. the device according to claim 30 is characterized in that, this apotheca is the apotheca with two chambers, is provided with the bypass section and apotheca is divided into the extra piston of two locellus with at least one.
54. the device according to claim 30 is characterized in that, this device is arranged to can be used for batching a plurality of dosage, and the space of the receiving fluids of its apotheca is greater than pressure chamber.
55. the device according to claim 30 is characterized in that, this pressure measuring cylinder has piston transfusion position in the wings, and at this piston position, conduit forms fluid with pressure measuring cylinder piston part before and is communicated with; And piston detent position forwardly, at this piston position, can not realize that fluid is communicated with.
56. the device according to claim 55 is characterized in that, shunting device allows liquid flow into the pressure chamber of piston front around piston when the transfusion position.
CNB018098606A 2000-05-22 2001-05-22 Medical arrangement Expired - Fee Related CN1255192C (en)

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HUP0302360A2 (en) 2003-10-28
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AR032333A1 (en) 2003-11-05

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