KR100784446B1 - Breast cancer diagnosis system using monochromatic soft x-ray - Google Patents

Abstract

A breast cancer diagnosis system using monochromatic soft x-ray is provided to maximize the efficiency of the breast cancer diagnosis system by obtaining an image with a high-resolution having a reduced amount of irradiation. A breast cancer diagnosis system using monochromatic soft x-ray includes a monochromatic soft x-ray generator(100). The monochromatic soft x-ray generator generates monochromatic soft x-ray. A light distributing device(200) provides the monochromatic soft x-ray for obtaining image and pattern. An optical device includes a microscopy signal obtaining optical part(310) and a fine angle x-ray dispersion pattern obtaining optical part(350). The microscopy signal obtaining optical part obtains an image in a soft x-ray microscopy method by using a single phased soft x-ray. A fine angle x-ray dispersion pattern obtaining optical part obtains an image in a fine angle x-ray dispersion pattern method by using the single phased soft x-ray. Signal detectors(450,400) detect image signals in real time. A signal processor transmits pattern and image data to a host computer(600). The host computer stores, analyzes, and demonstrates the pattern and image data.

Description

Breast cancer diagnosis system using monochromatic soft x-ray.

1 is a block diagram of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

2 is an exemplary view schematically showing a microscopic signal acquisition optical unit of the breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

FIG. 3 is an exemplary view schematically showing a micro-angle X-ray scattering pattern acquisition optical unit of a breast cancer diagnosis system using a single wavelength soft X-ray according to an embodiment of the present invention.

4 is a block diagram of a signal detection apparatus of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

5 is an exemplary view schematically illustrating a scanning method for a target object of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

6 is a block diagram of a signal processing apparatus of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

Explanation of symbols on the main parts of the drawings

10: object 100: single wavelength soft x-ray generator

200: optical distribution device 310: microscopy signal acquisition optical

350: minute angle X-ray scattering pattern optical unit 400: first signal detection device

450: second signal detection device 500: signal processing device

600: host computer

The present invention relates to a breast cancer diagnosis system using a single wavelength soft x-ray, and more particularly, to quantitatively diagnose breast cancer by acquiring a micro angle X-ray scattering pattern and a microscopy image using a single wavelength soft x-ray generated by an X-ray generator. It relates to a breast cancer diagnosis system using a single wavelength soft x-ray that can be performed.

The growth of medical and consciousness increased breast cancer early detection rate and improved cure rate, but the incidence of breast cancer was relatively high due to westernization of lifestyle, changes in food intake patterns and environmental pollution. Western lifestyles such as babies, higher birth rates, and fewer babies and no breastfeeding are also noted as factors influencing breast cancer. In addition, breast cancer shows a big difference according to the stages, so the cure rate is significantly decreased in stages 3 and 4 compared to stages 1 and 2, and more than half of patients are found after stage 3, so the technical growth of early diagnosis of breast cancer is urgent.

Conventional breast cancer early diagnosis methods used for this purpose include mammography, ultrasound, magnetic resonance imaging.

Mammography is the most widely used method of screening breast cancer recently. X-ray imaging is performed on a breast adhered to a plastic sheet. Although the procedure is relatively simple, due to the characteristics of the soft breast tissue, the image is blurred if the image is not compressed. Therefore, the compression is indispensable to obtain a clear image. In addition, due to the high density of adipose tissue, connective tissue and mammary tissue of the breast, it is impossible to distinguish between lumps and masses that can be detected by ultrasonography in the case of dense breasts showing white breasts and heterogeneous dense breasts. In addition, since the minimum detectable image is more than 5mm, it is difficult to detect microcalcification early and the diagnostic accuracy is not more than 80%.

Ultrasound method collects sound waves coming back from an object and acquires images from the breast to differentiate between water bumps and solid tumors, and to determine tumor size, shape, and density to distinguish cancer from benign tumors. It is easy when X-ray imaging is impossible or the diagnosis is ambiguous, such as a woman with a disease or a dense breast tissue or a pregnant woman who may be harmful to exposure to radiation, but it is also difficult to see the microcalcification accurately.

Magnetic resonance imaging was effective in identifying the extent and stage of breast cancer that had already been found, but it was not suitable for patients with obstructive phobia because of the high cost of the test, the long time taken, the complicated procedure, and the need to take pictures in a limited space.

Accordingly, the present invention has been made to solve the above conventional problems,

An object of the present invention by irradiating a single energy band, that is, a single wavelength having a single wavelength using a single wavelength soft x-rays generated in a single wavelength soft x-ray generator, the radiation exposure is up to 50% compared to the conventional breast cancer X-ray diagnostic apparatus It is to provide a breast cancer diagnosis system that is harmless to the human body by reducing and completely eliminating radiation in the low energy region where the human body absorbs the most.

Another object of the present invention is to simultaneously apply a micro-angle X-ray scattering method and a microscopy method to detect microcalcifications that provide the most useful information for early diagnosis of breast cancer, and to obtain a micro-angle X-ray scattering image, refractive image, and mice It is to provide an ultra-fine diagnostic image with nano resolution by acquiring scope images.

Another object of the present invention is unlike the conventional X-ray imaging apparatus that provides only a simple transmission image has a close relationship with the progression of breast cancer using a micro-angle X-ray scattering method and the major structural of the extra cellular matrix (ECM) in breast tissue Acquiring a micro-angle X-ray scattering pattern of the tissue state composed of the collagen protein as a component and applying a wavelet-based analysis method to provide quantitative information and accurate location of breast cancer.

Breast cancer diagnosis system using a single wavelength soft x-ray of the present invention for achieving the above object,

In the breast cancer diagnosis system,

A single wavelength extended X-ray generator for generating a single wavelength extended X-ray;

An optical distribution device for supplying a single wavelength soft x-ray to an optical device for acquiring an image and a pattern by a micro-angle x-ray scattering method and a microscopy method using a single wavelength soft x-ray generated by the single wavelength soft x-ray generator; ;

A microscopy signal acquisition optical unit for acquiring an image by a soft x-ray microscopy method using a single wavelength soft x-ray incident from the optical splitter;

An optical device including a micro-angle X-ray scattering pattern acquisition optical unit for acquiring a micro-angle X-ray scattering pattern by a micro-angle X-ray scattering method using a single wavelength soft X-ray incident from the light distribution device;

A second signal detection device for detecting in real time microscopic image signals obtained by diffraction obtained from the optical device;

A signal detection device including a first signal detection device for detecting a micro-angle X-ray scattering pattern obtained from the optical device;

A signal processing device for processing the detection signals input from the first signal detection device and the second signal detection device in real time to transmit pattern and image data to a host computer;

And a host computer configured to receive the pattern and image data from the signal processing apparatus, and to store, analyze, and present the data.

At this time, the single wavelength X-ray generator,

A femtosecond X-ray generator using a femtosecond pulse laser method for generating X-rays of a single wavelength is used, and the radiation of the soft X-ray region is used.

At this time, the optical distribution device,

The photonic crystal waveguide or the multi-mode interferometer is configured to have a reflection angle of 90 degrees and a transmission angle of 0 degrees internally using an optical splitter and a mirror.

At this time, the microscopy signal acquisition optical unit,

A spherical multilayer mirror for irradiating with a fine concentric diffraction plate by changing the path of a single wavelength soft x-ray incident from an optical splitter;

A micro-concentric diffraction plate projected from the spherical multilayer mirror to focus on a scan point of a target object and to increase spatial resolution of soft X-ray microscopy;

And an ordered alignment aperture for determining a refractive order with respect to a single wavelength soft X-ray incident to the fine concentric diffraction plate.

At this time, the microscopy signal acquisition optical unit,

A spherical multilayer mirror for irradiating with a fine concentric diffraction plate by changing the path of a single wavelength soft x-ray incident from an optical splitter;

A micro-concentric diffraction plate projected from the spherical multilayer mirror to focus on a scan point of a target object and to increase spatial resolution of soft X-ray microscopy;

It comprises an ordered aperture for determining the order of refraction for the single wavelength soft X-rays incident on the fine concentric diffraction plate,

Using a spherical multilayer mirror, a single wavelength delayed X-ray generator and a light distribution device, a fine concentric diffraction plate, an order-aligned aperture, a target object and a first signal detection device are all placed in front of the spherical multilayer mirror and passed through the light distribution device. A single wavelength X-ray is reflected by a spherical multilayer mirror and projected onto a target object, thereby reducing the beam path.

At this time, the micro-angle X-ray scattering pattern acquisition optical unit,

A first reflection mirror and a second reflection mirror for changing the beam path of the single wavelength soft x-rays incident from the light distribution device;

It is characterized in that it comprises a pinhole collimation means for removing the abnormal scattering line and to obtain a micro-angle X-ray scattering pattern for a large size sample.

At this time, the pinhole collimation means,

A first pinhole and a second pinhole for adjusting the size and focal length of the incident beam to determine the properties and characteristics of the incident beam;

And a guard pin hole for removing a scattering beam of a noise component generated by scattering at an inner boundary surface of the second pin hole.

At this time, the signal detection device,

A second CCD image sensor for detecting a microscopy image signal;

A microscopic image signal acquisition unit for controlling the second CCD image sensor, receiving a microscopic image signal from the second CCD image sensor, converting the microscopic image signal into digital data, and outputting microscopic image data;

A first CCD image sensor for detecting a micro-angle X-ray scattering pattern;

A fine angle scattering pattern signal acquisition unit for controlling the first CCD image sensor, receiving a fine angle scattering pattern from the first CCD image sensor, and converting the digital angle scattering pattern data into digital data;

And a synchronization circuit unit for providing synchronization for the signal conversion process of the micro-angle scattering pattern signal acquisition unit and the microscopic image signal acquisition unit.

At this time, the signal processing device,

A micro-angle scattering pattern signal processor for generating a micro-angle scattering image, a refraction image, and a micro-angle pattern set from the micro-angle scattering pattern data transmitted from the signal detection device;

A microscopy image signal processor for generating a microcrosscopy image from the microscopy image data transmitted from the signal detection apparatus;

A data transmitter for transmitting the micro-angle scattering pattern and the refraction image, the micro-angle pattern set, and the microscopic image transmitted from the micro-angle scattering pattern signal processor and the microscopic image signal processor;

The micro angle scattering pattern signal processing unit, the microscopic image signal processing unit and the main control unit for controlling the data transmission unit is characterized in that it comprises a.

At this time, the signal processing device,

In order to determine the presence or absence of breast cancer compared to the micro-angle scattering pattern image obtained from the normal breast, micro-angle scattering is performed by converting the micro-angle scattering pattern data for each frame into a pattern image on the wavelet domain using wavelet transform. A pattern image is generated.

In this case, the micro-angle scattering pattern signal processor and the microscopic image signal processor,

A 32-bit risk-only DSP processor and high-speed FPGA to perform hardware-based high-speed memory and high-speed signal processing algorithms to store micro-angle scattering pattern data and microscopic image data input frame by frame until scanning is completed. It is characterized in that the parallel processing to arrange and arrange.

At this time, the spherical multilayer mirror,

In order to scan the entire target object, the spherical multilayer mirror can be rotated in the vertical direction and the left and right directions so that the single wavelength soft X-ray projected from the spherical multilayer mirror onto the target object is the center of the fine concentric diffraction plate and the first signal detection device. It is characterized in that the spherical multi-layer mirror, the fine concentric diffraction plate and the first signal detection device can be designed to move in the same way.

At this time, the second reflection mirror,

In order to scan the entire target object, the second reflecting mirror can rotate in the vertical direction and the left and right directions. Accordingly, the second reflecting mirror passes through the guard pin hole and passes through the single wavelength soft X-ray projected on the target object. The guard pin hole and the second signal detection device may be designed to move in the same manner as the second reflection mirror so that the micro-angle scattering pattern may pass through the center of the second signal detection device.

Hereinafter, with reference to the accompanying drawings will be described in detail a preferred embodiment of the breast cancer diagnosis system using a single wavelength soft x-rays of the present invention.

1 is a block diagram of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

As shown in Figure 1, the present invention is a breast cancer diagnosis system using a single wavelength soft X-rays,

In the breast cancer diagnosis system,

A single wavelength lead x-ray generator 100 generating a single wavelength soft x-ray;

Optical distribution device for supplying single wavelength soft x-rays to an optical device for acquiring an image and a pattern by micro-angle X-ray scattering and microscopy using single wavelength soft x-rays generated by the single wavelength soft x-ray generator ( 200);

A microscopy signal acquisition optical unit 310 for acquiring an image by a soft x-ray microscopy method using a single wavelength soft x-ray incident from the optical splitter;

Optical device 300 including a micro-angle X-ray scattering pattern acquisition optical unit 350 for obtaining a micro-angle X-ray scattering pattern by a micro-angle X-ray scattering method using a single wavelength soft X-rays incident from the light distribution device )Wow;

A second signal detection device 450 for detecting in real time microscopic image signals obtained by diffraction obtained from the optical device;

A signal detection device including a first signal detection device 400 for detecting a micro-angle X-ray scattering pattern obtained from the optical device;

A signal processing device (500) for processing the detection signals input from the first signal detection device and the second signal detection device in real time to transmit pattern and image data to a host computer;

And a host computer 600 for receiving the pattern and the image data from the signal processing device for storing, analyzing, and presenting the data.

At this time, the single wavelength X-ray generator,

A femtosecond X-ray generator using a femtosecond pulse laser method for generating X-rays of a single wavelength is used, and it is characterized by using radiation in the soft X-ray region. Generally, a particle accelerator used to generate a single wavelength soft X-rays is used. Unlike a synchrotron generator or a plasma method, a femtosecond X-ray generator using a femtosecond pulse laser method that emits a single energy, that is, a single wavelength X-ray by the photoelectric effect by periodically firing a laser beam for an extremely short time of femtosecond, Diffraction phenomenon occurs well in soft tissues such as breast, and the radiation of soft X-ray region is used for acquiring microscopic X-ray scattering pattern or diffraction X-ray.

At this time, the optical distribution device,

A photon crystal waveguide or a multimode interferometer is used to configure the optical splitter and mirror to have a reflection angle of 90 ° and a transmission angle of 0 ° internally. The X-rays are supplied simultaneously to the optical unit for micro-angle X-ray scattering and the optical unit for the microscope.

2 is an exemplary view schematically showing a microscopic signal acquisition optical unit of the breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

As shown in Figure 2, the microscopy signal acquisition optical unit,

A spherical multilayer mirror 311 for changing the path of the single-wavelength soft x-rays incident from the light distribution device to be irradiated with a fine concentric diffraction plate,

A micro-concentric diffraction plate 313 for projecting from the spherical multilayer mirror to focus on a scan point of a target object and to increase spatial resolution of soft X-ray microscopy;

And an ordered alignment stop 312 for determining a refractive order with respect to a single wavelength soft X-ray incident to the fine concentric diffraction plate.

In this case, the microscopic signal acquisition optical unit generally positions the condenser concentric diffraction plate, the target object, the objective concentric diffraction plate, and the signal detection device in a row after the single wavelength lead X-ray generator, but it detects the signal from the single-wavelength X-ray generator. The beam path to the device has the disadvantage of being very long, so that the spherical multilayer mirror is used to make a single wavelength X-ray generator and the light distribution device and the microconcentric diffraction plate, the order alignment aperture, the target object and the first signal detection device. The single wavelength X-rays, which are located in front of the mirror and pass through the light distribution device, are reflected on the spherical multilayer mirror and projected onto the target object, thereby reducing the beam path.

In this case, the spherical multilayer mirror is used to increase the efficiency by reducing the reflectivity and exposure time, and according to the energy of the single-wavelength soft X-rays used to adjust the parameters such as the roughness of the sphere, the degree of mixing of the layer, the density Characterized in that the reflectivity of the mirror is determined.

In addition, the spherical multilayer mirror can be rotated in the vertical direction and the left and right directions to scan the entire object, so that the single wavelength soft X-rays irradiated from the spherical multilayer mirror are fine concentric diffraction plate, order alignment aperture and the first signal. It is characterized in that it is designed to move in the same way as the spherical multilayer mirror so as to pass through the center of the detection device.

In this case, the micro-concentric diffraction plate may further comprise a central blocking film to remove the dense beam in the center of the single wavelength soft X-rays irradiated from the spherical multilayer mirror and obtain a high quality microscopy image signal.

FIG. 3 is an exemplary view schematically showing a micro-angle X-ray scattering pattern acquisition optical unit of a breast cancer diagnosis system using a single wavelength soft X-ray according to an embodiment of the present invention.

As shown in Figure 3, the micro-angle X-ray scattering pattern acquisition optical unit,

A first reflecting mirror 351 and a second reflecting mirror 352 for changing the beam path of the single wavelength soft x-rays incident from the light distribution device;

And a pinhole collimation means for removing abnormal scattering lines and obtaining a micro-angle X-ray scattering pattern for a large sample.

At this time, the pinhole collimation means,

A first pin hole 353 and a second pin hole 354 for determining the nature and characteristics of the incident beam by adjusting the size and focal length of the beam that is incident;

And a guard pin hole 355 for removing the scattering beam of the noise component generated by scattering in the inner boundary surface of the second pin hole.

At this time, the first pinhole is to adjust the size of the pinhole to adjust the degree of incident flow due to the divergence present in the single wavelength soft X-rays generated from the source.

The guard pin hole should be designed and positioned as close as possible to the incident beam in order to maintain high resolution angular resolution, but avoid touching the main incident beam.

The second reflecting mirror and the guard pin hole should be moved together to sufficiently scan the entire sample.

In this case, the second reflecting mirror preferably rotates in the vertical direction and the left and right directions to scan the entire target object, and accordingly passes through the guard pin hole from the second reflecting mirror and is projected onto the target object. In order to allow the micro-angle scattering pattern passing through the target object to pass through the center of the second signal detection device, the guard pin hole and the signal detection device may be designed to move in the same manner as the second reflection mirror.

4 is a block diagram of a signal detection apparatus of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

As shown in Figure 4, the signal detection device,

A second CCD image sensor 420 for detecting a microscopy image signal,

A microscopic image signal acquisition unit 435 for controlling the second CCD image sensor, receiving a microscopic image signal from the second CCD image sensor, converting the microscopic image signal into digital data, and outputting microscopic image data;

A first CCD image sensor 410 for detecting a micro-angle X-ray scattering pattern;

A fine angle scattering pattern signal acquisition unit 430 for controlling the first CCD image sensor, receiving the fine angle scattering pattern from the first CCD image sensor, and converting the digital angle scattering pattern data into digital data;

And a synchronization circuit unit 440 for providing synchronization for the signal conversion process of the micro-angle scattering pattern signal acquisition unit and the microscopic image signal acquisition unit.

In this case, the 2CCD image sensor uses a large area sensor of 2 million pixels having a resolution of 2048 X 2048.

In this case, the micro-angle scattering pattern signal acquisition unit and the microscopic image signal acquisition unit control the first CCD image sensor and the second CCD image sensor through a driving clock and a control signal and are input from the first CCD image sensor and the second CCD image sensor. An AD converter for converting an analog signal into a digital signal is configured.

The synchronization circuit may be configured to synchronize coordinates of a scanning position of a target object focused on a single wavelength soft X-ray and a signal acquisition unit to synchronize a time of converting the micro-angle scattering pattern and the microscopic image signal into the micro-angle scattering pattern data and the microscopic image data. It is for.

5 is an exemplary view schematically illustrating a scanning method for a target object of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

Unlike the general image acquisition process, in order to acquire the micro-angle scattering pattern signal acquisition unit and the microscopic image signal acquisition unit to obtain the micro-angle scattering pattern and the microscopic image signal, each time the scanning position of the single wavelength soft X-ray is focused on the target object focused. One frame image and pattern signal must be acquired, and the scanning position of the target object is moved and repeatedly performed. The entire frame set obtained after scanning the entire area of the target object is processed by fine signal processing. A micro-angle scattering image, a refraction image, and a micro-angle pattern set are obtained from each scattering pattern data, and a microscopy image is obtained from the microscopy image data.

In addition, in order to acquire the micro-angle scattering pattern and the microscopic image signal, the single wavelength soft X-rays projected from the respective optical parts in the vertical direction scan the target object, resulting in quantum collisions with each other, resulting in single wavelength softening. In order to minimize the change of physical properties such as the angle of refraction of the beam output through the target object or the change of X-rays, the single wavelength soft X-ray for dividing the entire volume of the target object to obtain the micro-angle scattering pattern is A Starting at point, move to point A 'along the path and at the same time point C to acquire the microscopy image signal, start at point C' along the path, and again single-wavelength soft-axes to obtain micro-angle scattering patterns Starts at point B, moves along the path to point B 'and simultaneously Starting from point D to acquire the micro image signal Scorpion moves along a path to D ', and the point is the scanning.

6 is a block diagram of a signal processing apparatus of a breast cancer diagnosis system using a single wavelength soft x-ray according to an embodiment of the present invention.

As shown in Figure 6, the signal processing apparatus,

A micro-angle scattering pattern signal processor 510 for generating a micro-angle scattering image, a refraction image, and a micro-angle pattern set from the micro-angle scattering pattern data transmitted from the signal detection device;

A microscopy image signal processor 520 for generating a microscopy image from the microscopy image data transmitted from the signal detection apparatus;

A data transmitter 530 for transmitting the micro-angle scattering image, the refraction image, the micro-angle pattern set, and the microscopic image transmitted from the micro-angle scattering pattern signal processor and the microscopic image signal processor;

The micro-angle scattering pattern signal processor, a microscopy image signal processor, and a main control unit 540 for controlling the data transmitter is characterized in that it comprises a.

In addition, in order to determine the presence of breast cancer compared to the micro-angle scattering pattern image obtained from the normal breast, the micro-angle scattering pattern data of each input frame is transformed into a pattern image on the wavelet domain using wavelet transform to fine Each scattering pattern image is generated.

The micro-angle scattering pattern signal processor and the microscopic image signal processor,

A 32-bit risk-only DSP processor and high-speed FPGA to perform hardware-based high-speed memory and high-speed signal processing algorithms to store micro-angle scattering pattern data and microscopic image data input frame by frame until scanning is completed. It is characterized in that the parallel processing to arrange and arrange.

The micro-angle scattering pattern signal processor receives the micro-angle scattering pattern data represented by the Angular Intensity Spectrum in which the intensity of the beam is a function of the refraction angle. By calculating as follows, the total refraction angle for each frame is obtained, the weighting factor for each scanning position for each frame is given for each frame, and the result is matched by applying the Constrained Least-square (CLS) algorithm of Equation 2. A refractive image including mass intensity information is generated.

In this case, the micro-angle scattering pattern signal processing apparatus receives micro-angle scattering pattern data such as a distribution of radiation intensity (Equation 3) formed by coherent scattering radiation for each frame. Therefore, the micro-angle scattering pattern data for each input frame has the same meaning as the non-normalized spatial distribution of the electron density distribution of the target object. In addition, even though the micro-angle scattering pattern data for each input frame is decomposed into various spatial frequency bands by wavelet decomposition, the specific peak region in the pattern data does not change, so it is compared using discrete wavelet transform data. Correlation and correlation can be computed effectively and the morphological comparison can be processed accurately by energy composition within the wavelet domain. Therefore, the pattern on the wavelet domain is obtained by using a discrete wavelet transform as shown in Equation 4 with respect to the micro-angle scattering pattern data of each input frame to determine the presence or absence of breast cancer compared to the micro-angle scattering pattern image obtained from the normal breast. It is characterized by generating a micro-angle scattering pattern image by converting to an image.

In this case, the microscopic image signal processing generates a microscopic image from the input microscopic image data by using a Fourier filtering method. The input microscopy image data is the Fourier domain data for the complex wavefield passing through each of the two-dimensional scanning positions of the target object as shown in Equation 5, and the obtained complex scattering field and the signal detector response function as shown in Equation 6 After performing an operation based on a spatial frequency on the Fourier domain, an image may be acquired by an inverse Fourier transform.

Due to the above-mentioned configuration and characteristics, since the exposure amount is reduced to about one third of the intensity of X-rays generally used, it does not harm the human body at all and acquires high resolution diagnostic images, thereby maximizing the efficiency of early diagnosis and detection of breast cancer. You can do it.

Those skilled in the art to which the present invention pertains as described above may understand that the present invention may be implemented in other specific forms without changing the technical spirit or essential features of the present invention. Therefore, the above-described embodiments are to be understood as illustrative in all respects and not restrictive.

The scope of the invention is indicated by the following claims rather than the above description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the invention. do.

As described above, the breast cancer diagnosis system using a single wavelength soft x-ray of the present invention,

Since the exposure amount is reduced by about one third of the intensity of X-rays, which is generally used, it is harmless to the human body and by obtaining a high resolution diagnostic image, it is possible to maximize the efficiency of early diagnosis and detection of breast cancer.

In addition, by simultaneously acquiring the microscopic X-ray scattering pattern and the molecular structure pattern and image by microscopy using soft X-rays to provide a medical image based on a quantitative basis, it provides innovative technological advances in medical image reading.

In addition, the soft x-ray having a single wavelength provides an effect that provides a basis for a technique for analyzing and reconstructing data generated by an ultra-fine imaging technique of sub-nano units.

Claims (13)

In the breast cancer diagnosis system, A single wavelength extended X-ray generator for generating a single wavelength extended X-ray; An optical distribution device for supplying a single wavelength soft x-ray to an optical device for acquiring an image and a pattern by a micro-angle x-ray scattering method and a microscopy method using a single wavelength soft x-ray generated by the single wavelength soft x-ray generator; ; A microscopy signal acquisition optical unit for acquiring an image by a soft x-ray microscopy method using a single wavelength soft x-ray incident from the optical splitter; An optical device including a micro-angle X-ray scattering pattern acquisition optical unit for acquiring a micro-angle X-ray scattering pattern by a micro-angle X-ray scattering method using a single wavelength soft X-ray incident from the light distribution device; A second signal detection device for detecting in real time microscopic image signals obtained by diffraction obtained from the optical device; A signal detection device including a first signal detection device for detecting a micro-angle X-ray scattering pattern obtained from the optical device; A signal processing device for processing the detection signals input from the first signal detection device and the second signal detection device in real time to transmit pattern and image data to a host computer; And a host computer configured to receive pattern and image data from the signal processing device, and to store, analyze, and present the data. The method of claim 1, The single wavelength lead X-ray generator, A femtosecond X-ray generator using a femtosecond pulse laser method for generating single wavelength X-rays, and breast cancer diagnosis system using a single wavelength soft X-rays, characterized in that the use of radiation in the soft X-ray region. The method of claim 1, The optical distribution device, A system for diagnosing breast cancer using a single wavelength soft x-ray, characterized in that the photon crystal waveguide or a multi-mode interferometer is configured to have a reflection angle of 90 ° and a transmission angle of 0 ° internally using an optical splitter and a mirror. The method of claim 1, The microscopy signal acquisition optical unit, A spherical multilayer mirror for irradiating with a fine concentric diffraction plate by changing the path of a single wavelength soft x-ray incident from an optical splitter; A micro-concentric diffraction plate projected from the spherical multilayer mirror to focus on a scan point of a target object and to increase spatial resolution of soft X-ray microscopy; A breast cancer diagnosis system using a single wavelength soft x-ray, characterized in that it comprises an order-aligned aperture for determining the refractive order for the single wavelength soft x-ray incident on the fine concentric diffraction plate. The method of claim 1, The microscopy signal acquisition optical unit, A spherical multilayer mirror for irradiating with a fine concentric diffraction plate by changing the path of a single wavelength soft x-ray incident from an optical splitter; A micro-concentric diffraction plate projected from the spherical multilayer mirror to focus on a scan point of a target object and to increase spatial resolution of soft X-ray microscopy; It comprises an ordered aperture for determining the order of refraction for the single wavelength soft X-rays incident on the fine concentric diffraction plate, Using a spherical multilayer mirror, a single wavelength delayed X-ray generator and a light distribution device, a fine concentric diffraction plate, an order-aligned aperture, a target object and a first signal detection device are all placed in front of the spherical multilayer mirror and passed through the light distribution device. A system for diagnosing breast cancer using a single wavelength soft x-ray which reduces the beam path by reflecting a single wavelength soft x-ray onto a spherical multilayer mirror and projecting the target object. The method of claim 1, Acquisition of micro angle X-ray scattering pattern A first reflection mirror and a second reflection mirror for changing the beam path of the single wavelength soft x-rays incident from the light distribution device; And a pinhole collimation means for removing abnormal scattering lines and obtaining a micro-angle X-ray scattering pattern for a large sample. The method of claim 6, The pinhole collimation means, A first pinhole and a second pinhole for adjusting the size and focal length of the incident beam to determine the properties and characteristics of the incident beam; And a guard pin hole for removing a scattering beam of a noise component generated by scattering at the inner boundary surface of the second pin hole. The method of claim 1, The signal detection device, A second CCD image sensor for detecting a microscopy image signal; A microscopic image signal acquisition unit for controlling the second CCD image sensor, receiving a microscopic image signal from the second CCD image sensor, converting the microscopic image signal into digital data, and outputting microscopic image data; A first CCD image sensor for detecting a micro-angle X-ray scattering pattern; A fine angle scattering pattern signal acquisition unit for controlling the first CCD image sensor, receiving a fine angle scattering pattern from the first CCD image sensor, and converting the digital angle scattering pattern data into digital data; And a synchronization circuit for providing synchronization for the signal conversion process of the microangular scattering pattern signal acquisition unit and the microscopic image signal acquisition unit. The method of claim 1, The signal processing device, A micro-angle scattering pattern signal processor for generating a micro-angle scattering image, a refraction image, and a micro-angle pattern set from the micro-angle scattering pattern data transmitted from the signal detection device; A microscopy image signal processor for generating a microscopy image from the microscopy image data transmitted from the signal detection apparatus; A data transmitter for transmitting the micro-angle scattering pattern and the refraction image, the micro-angle pattern set, and the microscopic image transmitted from the micro-angle scattering pattern signal processor and the microscopic image signal processor; And a micro-scattering pattern signal processing unit, a microscopy image signal processing unit, and a main control unit for controlling the data transmission unit. The method of claim 1, The signal processing device, In order to determine the presence or absence of breast cancer compared to the micro-angle scattering pattern image obtained from the normal breast, micro-angle scattering is performed by converting the micro-angle scattering pattern data for each frame into a pattern image on the wavelet domain using wavelet transform. Breast cancer diagnosis system using a single wavelength soft x-rays, characterized in that to generate a pattern image. The method of claim 9, The micro-angle scattering pattern signal processor and the microscopic image signal processor, A 32-bit risk-only DSP processor and high-speed FPGA to perform hardware-based high-speed memory and high-speed signal processing algorithms to store micro-angle scattering pattern data and microscopic image data input frame by frame until scanning is completed. A system for diagnosing breast cancer using a single wavelength soft x-ray, characterized in that for connecting and arranging in parallel structure. The method according to claim 4 or 5, The spherical multilayer mirror, In order to scan the entire target object, the spherical multilayer mirror can be rotated in the vertical direction and the left and right directions so that the single wavelength soft X-ray projected from the spherical multilayer mirror onto the target object is the center of the fine concentric diffraction plate and the first signal detection device. A system for diagnosing breast cancer using a single wavelength soft x-ray, characterized in that the spherical multilayer mirror, the micro-concentric diffraction plate and the first signal detection device are designed to move in the same manner. The method of claim 6, The second reflection mirror, In order to scan the entire target object, the second reflecting mirror can rotate in the vertical direction and the left and right directions. Accordingly, the second reflecting mirror passes through the guard pin hole and passes through the single wavelength soft X-ray projected on the target object. A breast cancer diagnosis system using a single wavelength soft x-ray, characterized in that the guard pin hole and the second signal detection device is designed to move in the same manner as the second reflection mirror so that the micro angle scattering pattern passes through the center of the second signal detection device. .

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