KR100740974B1 - Rna 앱타머 및 그의 용도 - Google Patents
Rna 앱타머 및 그의 용도 Download PDFInfo
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- KR100740974B1 KR100740974B1 KR1020050094404A KR20050094404A KR100740974B1 KR 100740974 B1 KR100740974 B1 KR 100740974B1 KR 1020050094404 A KR1020050094404 A KR 1020050094404A KR 20050094404 A KR20050094404 A KR 20050094404A KR 100740974 B1 KR100740974 B1 KR 100740974B1
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- rna
- catenin
- tcf
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- aptamer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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Abstract
Description
Claims (15)
- 서열번호 1로 기재되는 베타 카테닌에 결합하는 RNA 앱타머.
- 삭제
- 제 1항의 RNA 앱타머를 함유하는 유전자 발현 조절제.
- 제 3항에 있어서, 유전자가 cyclin D1 또는 c-myc 유전자인 것을 특징으로 하는 유전자 발현 조절제.
- 제 1항의 RNA 앱타머를 함유하는 베타-카테닌과 타 단백질 간 상호작용 저해제.
- 베타 카테닌에 결합하고, 서열번호 2로 기재되는 DNA로부터 전사되는 RNA 인트라머 발현용 재조합벡터.
- 삭제
- 제 1항의 RNA 앱타머 또는 제 6항의 인트라머가 발현되는 재조합벡터를 유효성분으로 함유하는 항암제.
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050094404A KR100740974B1 (ko) | 2005-10-07 | 2005-10-07 | Rna 앱타머 및 그의 용도 |
US12/064,384 US7999089B1 (en) | 2005-10-07 | 2006-10-09 | RNA aptamers and the uses thereof |
PCT/KR2006/004048 WO2007043784A1 (en) | 2005-10-07 | 2006-10-09 | Rna aptamers and the uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050094404A KR100740974B1 (ko) | 2005-10-07 | 2005-10-07 | Rna 앱타머 및 그의 용도 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20070039269A KR20070039269A (ko) | 2007-04-11 |
KR100740974B1 true KR100740974B1 (ko) | 2007-07-20 |
Family
ID=37942982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020050094404A KR100740974B1 (ko) | 2005-10-07 | 2005-10-07 | Rna 앱타머 및 그의 용도 |
Country Status (3)
Country | Link |
---|---|
US (1) | US7999089B1 (ko) |
KR (1) | KR100740974B1 (ko) |
WO (1) | WO2007043784A1 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL212696B1 (pl) * | 2008-02-14 | 2012-11-30 | Inst Chemii Bioorg Pan | Inhibitor rybonukleazy Dicer |
US9944933B2 (en) * | 2014-07-17 | 2018-04-17 | Georgia Tech Research Corporation | Aptamer-guided gene targeting |
CN104388422B (zh) * | 2014-10-24 | 2017-08-25 | 集美大学 | 寡核苷酸序列及其制备方法与应用 |
CN104844691B (zh) * | 2015-05-22 | 2017-12-22 | 中国人民解放军南京军区福州总医院 | Sox2蛋白肽适配子及其鉴定 |
US20200158716A1 (en) * | 2017-07-17 | 2020-05-21 | Massachusetts Institute Of Technology | Cell atlas of healthy and diseased barrier tissues |
CN107941767A (zh) * | 2017-11-23 | 2018-04-20 | 王颖皓 | 基于核酸适体荧光探针gsh2的谷胱甘肽试剂盒及其检测方法 |
WO2023183873A1 (en) * | 2022-03-24 | 2023-09-28 | Mensura Health Inc. | Aptamers and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004274861A1 (en) * | 2003-06-06 | 2005-03-31 | Wyeth | Methods and materials for identifying agents which modulate bone remodeling and agents identified thereby |
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2005
- 2005-10-07 KR KR1020050094404A patent/KR100740974B1/ko active IP Right Grant
-
2006
- 2006-10-09 WO PCT/KR2006/004048 patent/WO2007043784A1/en active Application Filing
- 2006-10-09 US US12/064,384 patent/US7999089B1/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
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Mol. Cells 17(1): 174-179 (2004.2.29, 인용발명) |
Also Published As
Publication number | Publication date |
---|---|
US7999089B1 (en) | 2011-08-16 |
KR20070039269A (ko) | 2007-04-11 |
WO2007043784A1 (en) | 2007-04-19 |
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