KR100696428B1 - A panties of pregnancy and ovulation for diagnosis - Google Patents

Abstract

A panty for diagnosing pregnancy and the ovulation day is provided to enable a user to directly check pregnancy or the ovulation day, and be resistant to washing or an external environment by micro-capsulizing, thereby able to being used continuously. The panty(100) for diagnosing pregnancy and the ovulation day consists of: at least one test paper(22,24,26) coated with a reagent which is inserted into a panty(100) and diagnoses at least any one of pregnancy or the ovulation day by urine; an attachment plate(30) which compartments the at least one test paper(22,24,26) and is attached with the at least one test paper(22,24,26); and an insertion part(10) which is formed to insert the attachment plate(30) having at least one test paper(22,24,26) through an opening part(12) placed at the front part of a panty(100).

Description

A panties of pregnancy and ovulation for diagnosis

1 is a perspective view according to a preferred embodiment of the present invention.

2 is a development view according to a preferred embodiment of the present invention.

Figure 3 is a development view showing that the insertion portion of the other shape in Figures 1 and 2.

Figure 4 is a development view showing that the pad made in accordance with another embodiment of the present invention.

5 is a development view according to another embodiment of the present invention.

Figure 6 is a perspective view according to an embodiment according to the present invention.

<Description of Symbols for Main Parts of Drawings>

10: insertion part 22, 24, 26: test paper

30: attachment plate 40: reagent

50: microcapsules 60: receiver

70: optical fiber 80: display unit

100: panties

The present invention relates to panties for diagnosing pregnancy and ovulation day, and more particularly, to panties for pregnancy and ovulation due to physiological changes due to pregnancy and ovulation by urine of women wearing panties.

Currently, urine pregnancy is checked by using a tester purchased from a pharmacy to check pregnancy if the first urine in the morning is buried at the end of the diagnostic device to improve the accuracy of the measurement. Is the reality.

In addition, a tester for self-diagnosis of ovulation days in women's urine is being sold at pharmacies and the Internet so as to know the fertility due to ovulation.

When ovulation is known, it is easy to predict that menstruation will occur 13 to 15 days after ovulation, but elementary or junior high school students who have not had menstruation have never experienced menstruation, so they are not aware of changes in their body before they have menstruation. I don't know the feeling and don't know the date, so I feel embarrassed because I have no defense at all.

To date, whether there is physiology according to pregnancy or ovulation date has been inconvenient to visit the hospital or buy a self-diagnosis pregnancy and ovulation day tester at the pharmacy to test.

In addition, once used pregnancy, ovulation day tester had to be discarded once used, there was a problem that can not be regenerated.

An object of the present invention is to provide a pregnancy, ovulation day diagnostic panties that enable women to immediately know their pregnancy, ovulation date by wearing only panties, and to prepare for menstruation by elementary school students or junior high school students close to menarche knowing the ovulation day have.

In addition, one panty continuously provides women with pregnancy, ovulation day diagnosis panties that can know their pregnancy, ovulation date.

The present invention for solving this problem relates to a panty for pregnancy, ovulation day, and more particularly, one or more test strips embedded in the panty buried with a reagent for diagnosing any one or more of pregnancy or ovulation days; A support plate partitioning said at least one test paper and having said at least one test paper attached thereto; It relates to a panty for pregnancy and ovulation day, characterized in that it consists of a panty with an insertion portion formed so that the support plate attached to the at least one test paper is inserted through the opening in the front portion.

In addition, one or more test strips inserted in the panties buried with a reagent for diagnosing any one or more of pregnancy or ovulation days with urine; A pad supporting plate partitioning the at least one test paper and having the at least one test paper attached thereto, and having an adhesive applied thereon; The present invention relates to a panty for pregnancy and ovulation day, characterized in that the pad-shaped support plate is attached.

In addition, the anti-human chorionic gonadotropin of the goat as a reagent that reacts to human chorionic gonadotropin (hCG) among the components of the urine so as to identify the pregnancy in the pregnancy and ovulation day panties. Using a mixture of pins (human chorionic gonadotropin (hCG) monoantibody-colloidal gold particles, using a luteinizing hormone-specific antibody (Antibody) as a reagent that reacts to the luteinizing hormone in the urine component to know the ovulation date In addition, the present invention relates to a pancreas for pregnancy and ovulation day, characterized in that a follicular estrogen (steroid gluronides) specific antibody is used as a reagent that reacts to the follicle estrogen (steroid gluronides).

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Hereinafter, the present invention will be described according to one preferred embodiment of the present invention.

1 is a perspective view according to a preferred embodiment of the present invention, Figure 2 is a development view according to a preferred embodiment of the present invention, Figure 3 is a development view showing that the insertion portion of the other shape is formed in Figures 1 and 2, 4 is an exploded view showing a pad shape according to another embodiment of the present invention, Figure 5 is a development view according to another embodiment of the present invention, Figure 6 is an embodiment according to the present invention A perspective view.

<Example 1>

As shown in FIGS. 1 to 3, the present invention forms inserting portions 10 and 10a having openings 12 and 12a formed in front of the panties 100 and 100a. 10a) is a reagent that reacts to human chorionic gonadotropin (hereinafter referred to as 'hCG'), luteinizing hormone, and ovarian steroid gluronides, which are detected in the urine during pregnancy and ovulation. The base plates 30 and 30a to which the embedded test paper was partitioned and attached were inserted.

The test paper 1 (22, 22a) of the test paper containing the reagents illustrated below indicates pregnancy diagnosis, and the test paper 2 (24, 24a) shows the ovulation due to the change in the amount of luteinizing hormone. , Test Paper 3 (26, 26a) shows the presence of ovulation due to the change in the amount of steroid gluronides of the follicle.

As shown in Figures 1, 2, 3, the insertion portion 10, 10a is preferably formed to be exposed to react directly with the urine, the test paper 22, 22a, 24, 24a, through the opening 12, 12a, It will be easy to replace the support plates (30, 30a) attached to the 26, 26a).

The inserts 10 and 10a may be formed in various ways so that the support plate to which the test paper is attached can be easily replaced and easily fixed inside the panties.

As shown in FIG. 3, the openings 12a are formed at the end portions of the insertion portions 10a with four triangular-shaped insertion portions 10a aligned with the edges of the supporting plate 30a, respectively. To be easily replaced or fitted.

The test papers 1, 2, and 3 contain reagents that react with hCG, luteinizing hormone, and follicle steroid gluronides, respectively, to determine whether pregnancy and ovulation exist, and the reaction principle of reacting the reagent with urine. Pregnancy and ovulation due to the change in color according to the reaction principle is listed as follows.

1. Principles of Pregnancy Diagnosis and Other Changes in Examination Sheet 1 (22, 22a)

The fertilized egg formed by combining sperm and egg is implanted on the endometrium to form the placenta, and the syncytiotrophoblast of the placenta secretes the glycoprotein hormone hCG (molecular weight 36,700) from 6 to 8 days after fertilization. do.

In normal pregnancy, the amount of hCG in urine during pregnancy is as follows.

Pregnancy period Human chorionic gonadotropin (hCG) concentration in urine (lU / L) 5-6 weeks 1,000-60,000 7-8 weeks 4,000-250,000 9 Weeks 8,000-25,000 10-14 weeks 16,000-520,000 After 15 weeks 8,000-250,000

In order to easily determine the presence of a conventional pregnancy, hCG antibodies are synthesized and purified from cells such as mice and goats, and a monoclonal antibody (monoclonal antibody) that specifically binds to hCG is obtained. In reality, the test paper 1 used in the tester is divided into a connection site and a pregnancy diagnosis site, and the connection site (J in FIGS. 2 and 3) contains a mixture of mouse anti-hCG monoantibody-colloidal gold particles (Mouse anti hCG). The monoclonal antibody-colloidal gold conjugate and Goat anti hCG polyclonal antibody were applied to the pregnancy indication part of the pregnancy diagnosis site, and the goat anti-mouse antibody (Goat anti) on the test completion indication part of the pregnancy diagnosis area. -mouse antibody (lgG) is applied. At this time, the amount of the anti-hCG monoantibody-colloidoid gold particle mixture of the rat is applied more than the amount of the goat anti-hCG complex of the pregnancy indicator (T in Figs. 2 and 3).
In the case of pregnancy, when urine moves on test paper 1 and hCG in urine binds to the anti-hCG monoantibody-colloidal gold particle mixture of rats, the conjugate continues to move in the direction of urine movement. In T) in stays in combination with chlorine's anti-hCG complex antibody and any particular color is deposited.

And, the remaining hCG monoantibody-colloidal gold particles mixture of surplus rats remaining on the pregnancy display window continue to move and remain in combination with the anti-mouse antibody of goats applied to the end-of-test display part (C in FIGS. 2 and 3). The specific color of the pregnancy display unit, the end of the test display line will appear respectively.

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In the case of pregnancy, the urine moves on test paper 1, but since there is no hCG in the urine, it does not bind to the anti-hCG complex antibody of the mouse and just passes, and the goat is only applied to the end-of-test indicator (C in Figs. 2 and 3). Only one line is shown by binding to the anti mouse antibody.

2. Ovulation Diagnosis Principle and Changes in Test Sheets 2 and 3 (24, 24a, 26, 26a)

Prediction of ovulation time in women is based on natural contraception using rhythm method, temperature change on basal body temperature, change according to menstrual cycle of cervical mucus, observation of follicle growth and follicular rupture using ultrasonography, blood or Urine concentrations are measured, but the most reliable indicators of ovulation time to date are the changes in luteinizing hormone and the amount of changes in follicle steroid gluronides.

The change in luteinizing hormone is usually 13.5mIU / ml ~ 73.0 mIU / ml in the case of ovulation and clear plan easy as a tester for diagnosing the ovulation in accordance with the change in luteinizing hormone (Clear Plan Easy) In fact, products such as Ovukit, OvuQuick, Sure Step, and EZ LH are currently in use.

The tester used is a progesterone-specific antibody as a reagent reacting to luteinizing hormone that responds to luteinizing hormone and steroid gluronides, as described above in the pregnancy diagnosis principle. As a reagent for steroid gluronides, follicular steroid gluronides-specific antibodies are used. Usually, primary secondary antibodies (NBT; Nitro Blue Tetrazolium), BCIP (BCIP) are used. -bromo-4-chloro-3-indolyl phosphate) and horserabish peroxidase attached to the antibody reacts to the antibody. It will be visible and visible.

Example 2

By using the test paper and the support plate used in Example 1 by applying the adhesive 32 to the part directly in contact with the panties 100b, which is the lower portion of the support plate 30b to which the test papers 22b, 24b, and 26b are attached, the pads are manufactured in a pad shape. You can easily attach or remove the pads as needed.

The pad-type coated with the adhesive is a reality that is widely used in women's sanitary napkin.

Pregnancy diagnosis and ovulation day used in Example 1 is the same as the diagnosis mechanism is omitted in Example 2.

Example 3

The microcapsules by microencapsulating the reagents contained in the test paper in Example 1 are made of a non-aqueous material as shown in Figs. 5 and 6 and breakable according to changes in external pressure or temperature. The agent was radiated to the front part inside the panties 100c to be broken by the human body temperature or by the pressure of the human movement, thereby exposing the reagent 40 contained in the microcapsule 50.

The pregnancy diagnosis was microencapsulated a mixture of mouse anti hCG monoclonal antibody-colloidal gold conjugate (mouse anti hCG monoclonal antibody-colloidal gold conjugate) described in Example 1, goat anti hCG polyclonal antibody (Goat anti hCG polyclonal antibody ) HCG hormone in the urine breaks down due to human body temperature or human movement pressure and binds to a mixture of detected anti-hCG monoantibody-colloidal particles. The combination of anti hCG monoclonal antibody-colloidal gold particles of Goat anti hCG polyclonal antibody (Goat anti hCG polyclonal antibody) is combined to show a change in color, and thus can confirm pregnancy.

The reagents are chemically reacted with the hormones inherent in the aforementioned urine, and the receiving unit 60 that recognizes the chemical reaction receives the chemical reaction, and transmits a signal recognized by the receiving unit 60. (70) was connected to the display portion (80).

Receiving unit 60 for receiving the chemical reaction generates heat by the combination of the reagents and the anti-body reacting with the reagents, but the heat is fine, the anti-body reacting with the reagents and the reagents are combined It is preferable to form a receiving unit capable of receiving the amplified heat by amplifying the minute heat generated in the chemical reaction by adding a heat generating material.

Naturally, the optical fiber 70 performs a role of a delivery unit.

The reagent 40 is microencapsulated as illustrated to quilt the pregnancy diagnosis site and the ovulation diagnosis site, thereby partitioning the mixture of anti-hCG monoantibody-colloidal gold particles of the chlorine, corpus luteinizing hormone-specific antibody Of course, it is natural that the receiver 60 recognizes each of the reactions caused by the combination of the anti-body and the hormone in the urine of the steroid gluronides specificity of the follicle.

The display unit 80 is partitioned to display chemical reactions of each reagent and urine when the chemical reaction of each reagent and urine is displayed.

Goat's anti-hCG complex antibody in the pregnancy indicator (T in Figs. 2 and 3) used in Examples 1 and 2, goat's anti-mouse antibody applied to the test completion indicator (C in Figs. 2 and 3), It is desirable to insert a substance capable of prolonging color into each of the luteinizing hormone specific antibody and the steroid gluronides specific antibody of the follicle so that the detected specific color is maintained for a certain time.

Although the present invention has been described in detail with reference to the embodiments described above, the present invention is not limited thereto, and the present invention may be substituted, changed, and improved within the ordinary knowledge of a person skilled in the art.

The present invention enables women to know their pregnancy and ovulation days by wearing only panties, and primary or middle school students close to menarche to be able to immediately check the ovulation day by eye to prepare for menstruation.

In addition, one woman can know the pregnancy and ovulation day of the woman continuously with one panty, and by using microencapsulation, it is strong in washing or external environment and can be used continuously.

Claims (7)

One or more test strips inserted in the panty and buried with a reagent capable of diagnosing at least one of pregnancy or ovulation days; A support plate partitioning said at least one test paper and having said at least one test paper attached thereto; Pregnancy and ovulation day diagnostic panties, characterized in that the panties are provided with an insertion portion formed so that the support plate attached to the one or more test papers through the opening in the front portion. One or more test strips inserted into the panty and buried with a reagent capable of diagnosing at least one of pregnancy or ovulation days with urine; A pad supporting plate partitioning the at least one test paper and having the at least one test paper attached thereto, and having an adhesive applied thereon; Pregnancy and ovulation day diagnosis panties, characterized in that consisting of panties with the pad-shaped support plate attached. The method according to claim 1 or 2, Chlorine's anti-human chorionic gonadotropin (hCG) monoantibody-a reagent that reacts to human chorionic gonadotropin (hCG) in the urine to identify the pregnancy A mixture of colloidal gold particles is used, and a luteinizing hormone specific antibody is used as a reagent that reacts to luteinizing hormone in the urine component to know the scheduled date of the ovulation day, and steroid gluronides of the follicle in the urine component. A pancreas for pregnancy and ovulation day, characterized in that the use of follicular steroid gluronides specific antibodies as a reagent to react. delete delete delete delete

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