KR100576335B1 - Processes for preparing 3-Z-propenyl cephem derivatives - Google Patents
Processes for preparing 3-Z-propenyl cephem derivatives Download PDFInfo
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- KR100576335B1 KR100576335B1 KR1020030076359A KR20030076359A KR100576335B1 KR 100576335 B1 KR100576335 B1 KR 100576335B1 KR 1020030076359 A KR1020030076359 A KR 1020030076359A KR 20030076359 A KR20030076359 A KR 20030076359A KR 100576335 B1 KR100576335 B1 KR 100576335B1
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- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
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Abstract
본 발명은 물, 이소프로판올, 및 메틸렌 클로라이드를 각각 1 : 3∼6 : 11∼14 의 비율(부피비)로 포함하는 혼합용매 중에서 화학식 2의 화합물을 염기 존재하에서 아세트알데히드와 반응시키는 단계를 포함하는 화학식 1의 3-(Z)-프로페닐 세펨 유도체의 입체선택적 제조방법을 제공한다:The present invention includes a step of reacting a compound of formula (2) with acetaldehyde in the presence of a base in a mixed solvent containing water, isopropanol, and methylene chloride in a ratio (volume ratio) of 1: 3 to 6:11 to 14, respectively. Provided is a stereoselective process for the preparation of 3- (Z) -propenyl cefem derivatives of 1:
<화학식 1><Formula 1>
<화학식 2><Formula 2>
식 중, R1은 카르복실 보호기이며, R2는 수소 또는 아미노 보호기이다.In formula, R <1> is a carboxyl protecting group and R <2> is hydrogen or an amino protecting group.
3-(Z)-프로페닐 세펨, 세프프로질3- (Z) -propenyl cefem, ceproprozil
Description
본 발명은 3-(Z)-프로페닐 세펨 유도체의 입체선택적 제조방법에 관한 것이다.The present invention relates to a stereoselective process for the preparation of 3- (Z) -propenyl cefem derivatives.
3-(Z)-프로페닐 세펨 유도체는 경구용 세팔로스포린계 항생제인 세프프로질의 제조용 중간체로서 유용한 화합물이며, 이를 제조하는 다양한 방법이 알려져 있다.3- (Z) -propenyl cefem derivatives are compounds useful as intermediates for the preparation of ceproprozil, an oral cephalosporin-based antibiotic, and various methods of preparing them are known.
국제특허 공개 제WO93/16084호에는 7-아미노-3-(1-프로펜-1-일)-3-세펨-카르복실산을 그의 하이드로클로라이드, 금속 또는 삼차아민염을 이용하거나 흡착크로마토그래피를 통한 분리방법으로 3-(Z)-프로페닐 세펨 화합물을 선택적으로 분리하는 방법이 개시되어 있으나, 분리 및 정제에 고비용이 소모된다는 단점이 있다.WO 93/16084 discloses 7-amino-3- (1-propen-1-yl) -3-cefe-carboxylic acid using its hydrochloride, metal or tertiary amine salts or adsorption chromatography. Although a method of selectively separating 3- (Z) -propenyl cefem compound is disclosed as a separation method through, a disadvantage is that high cost is required for separation and purification.
또한, 영국특허 제2,135,305호에는 아미노기가 t-부톡시카보닐기로 보호된 4-히드로페닐글리신 화합물과 카르복시기가 벤즈하이드릴로 보호된 세펨 화합물로부터 세프프로질을 제조하는 방법이 개시되어 있으나, 아실화 반응 후에 3-프로페닐기를 도입하게 되어 반응의 효율성이 떨어지며, 이성질체를 분리하기 위하여 고 성능 액체크로마토그래피를 사용해야 된다는 단점으로 산업화하기 어려운 문제점이 있다.In addition, British Patent No. 2,135,305 discloses a process for preparing cefeprozil from a 4-hydrophenylglycine compound in which an amino group is protected with a t-butoxycarbonyl group and a cefem compound in which the carboxy group is protected with benzhydryl. Since the introduction of 3-propenyl group after the silization reaction decreases the efficiency of the reaction, it is difficult to industrialize due to the disadvantage of using high performance liquid chromatography to separate the isomers.
미국특허 제 4,727,070 호에서는 세프프로질의 Z/E 혼합물을 아세톤과 반응시켜 이미다졸리디논 나트륨등의 활성기를 도입한 후 다시 탈보호하여 E-이성질체를 제거하는 방법을 개시하고 있으나, 크로마토 그래피에 의한 정제방법의 도입으로 비용이 많이 소모된다는 단점이 있다. U.S. Patent No. 4,727,070 discloses a method of removing E-isomers by reacting a Z / E mixture of ceproprozil with acetone, introducing an active group such as imidazolidinone sodium, and then deprotecting it again. The introduction of a purification method has the disadvantage that the cost is high.
한편, 대한민국 특허공개 제2002-80838호는 상기 종래기술의 문제점을 해결하기 위한 방법으로서, 포스포라닐리덴 세펨 화합물을 에테르를 필수용매로 함유하는 혼합용매 중에서 염기의 존재하에 아세트알데히드와 반응시켜 3-(Z)-프로페닐 세펨 화합물을 제조하는 방법을 개시한 바 있다. 더욱이, 대한민국 특허공개 제2002-80838호는 에테르가 필수적으로 사용되어야 함을 지적하고 있으며, 메틸렌 클로라이드, 테트라히드로퓨란 등을 사용하여 반응을 진행시킬 경우 여타의 반응조건, 예를 들어, 반응온도, 반응시간, 염기, 촉매 등을 변화시켜 주어도 Z-이성체의 함유량을 83% 이상으로 조절하기가 극히 어려움을 지적하고 있다.On the other hand, the Republic of Korea Patent Publication No. 2002-80838 is a method for solving the problems of the prior art, by reacting the phosphoranylidene cefme compound with acetaldehyde in the presence of a base in a mixed solvent containing ether as an essential solvent 3 A method for preparing a-(Z) -propenyl cefem compound has been disclosed. Moreover, Korean Patent Laid-Open Publication No. 2002-80838 indicates that ether should be used essentially, and other reaction conditions such as reaction temperature, for example, when methylene chloride, tetrahydrofuran, etc. are used to proceed the reaction, It is pointed out that even if the reaction time, base, catalyst and the like are changed, it is extremely difficult to control the content of the Z-isomer to 83% or more.
본 발명자들은 새로운 3-(Z)-프로페닐 세펨 유도체를 입체선택적으로 제조하기 위한 방법을 개발하고자 연구를 거듭한 결과, 놀랍게도 선행기술(대한민국 특허공개 제2002-80,838호)에서 지적한 것과는 상반되게 메틸렌클로라이드, 이소프로필알콜 및 물을 일정한 비율로 함유한 혼합용매를 사용하여 반응을 진행시킬 경우, 효과적으로 3-(Z)-프로페닐 세펨 유도체를 입체선택적으로 제조할 수 있다는 것을 발견하여 본 발명을 완성하게 되었다.The inventors of the present invention sought to develop a method for stereoselectively preparing a new 3- (Z) -propenyl cefem derivative, which is surprisingly contrary to that indicated in the prior art (Korean Patent Publication No. 2002-80,838). When the reaction is carried out using a mixed solvent containing chloride, isopropyl alcohol and water in a constant ratio, the present invention was found to be able to effectively prepare 3- (Z) -propenyl cefem derivative in stereoselective manner. Was done.
따라서, 본 발명은 메틸렌클로라이드, 이소프로필알콜 및 물을 일정한 비율로 함유한 혼합용매를 사용한 3-(Z)-프로페닐 세펨 유도체의 입체선택적 제조방법을 제공하는 것을 목적으로 한다.Accordingly, an object of the present invention is to provide a method for stereoselective preparation of 3- (Z) -propenyl cefem derivative using a mixed solvent containing methylene chloride, isopropyl alcohol and water at a constant ratio.
본 발명의 일 태양에 따라, 물, 이소프로판올, 및 메틸렌 클로라이드를 각각 1 : 3∼6 : 11∼14 의 비율(부피비)로 포함하는 혼합용매 중에서 화학식 2의 화합물을 염기 존재하에서 아세트알데히드와 반응시키는 단계를 포함하는 화학식 1의 화합물의 입체선택적 제조방법이 제공된다:According to one aspect of the present invention, a compound of formula (2) is reacted with acetaldehyde in the presence of a base in a mixed solvent containing water, isopropanol, and methylene chloride in a ratio (volume ratio) of 1: 3 to 6:11 to 14, respectively. Provided is a stereoselective process for preparing a compound of Formula 1 comprising the steps of:
식 중, R1은 카르복실 보호기이며, R2는 수소 또는 아미노 보호기이다.In formula, R <1> is a carboxyl protecting group and R <2> is hydrogen or an amino protecting group.
본 명세서에서 "입체선택적" 화합물이라 함은 Z-이성체(또는 시스(cis)-이성체) 형태 및 E-이성체(또는 트랜스(trans)-이성체) 형태의 화합물(예를 들어, 화학 식 1 또는 화학식 4의 화합물)이 각각 약 89 내지 94% 및 약 6 내지 11%의 비율로 혼합되어 있는 화합물로서, Z-이성체 및 E-이성체의 비율이 약 8.1 내지 15.7 : 1.0 의 범위를 갖는 화합물을 말한다. 따라서, "입체선택적" 제조방법이라 함은 상기 "입체선택적" 화합물의 제조방법을 말한다.As used herein, a “stereoselective” compound refers to a compound in a Z-isomer (or cis-isomer) form and an E-isomer (or trans-isomer) form (eg, in Formula 1 or Formula 1). 4) is a compound having a ratio of about 89 to 94% and about 6 to 11%, respectively, wherein the ratio of the Z-isomer and the E-isomer is in the range of about 8.1 to 15.7: 1.0. Thus, the term "stereoselective" preparation refers to a process for preparing said "stereoselective" compounds.
상기 카르복실 보호기 및 아미노 보호기는 세팔로스포린계 항생제 합성시 통상적으로 사용되는 보호기일 수 있으며, 예를 들어 카르복실 보호기는 알릴, 벤질, p-메톡시벤질, p-니트로벤질, 트리페닐메틸, 디페닐메틸 등을 포함하고, 아미노 보호기는 벤질카보닐, 4-메톡시벤질, 벤질리덴, 디페닐메틸, 트리페닐메틸 등을 포함한다. 이들 중, 카르복실 보호기 및 아미노 보호기는 각각 4-메톡시벤질 및 벤질카보닐인 것이 상업적으로 구입가능하므로 더욱 바람직하다. The carboxyl protecting group and amino protecting group may be a protecting group commonly used in the synthesis of cephalosporin-based antibiotics, for example, the carboxyl protecting group may be allyl, benzyl, p-methoxybenzyl, p-nitrobenzyl, triphenylmethyl, Diphenylmethyl and the like, and amino protecting groups include benzylcarbonyl, 4-methoxybenzyl, benzylidene, diphenylmethyl, triphenylmethyl and the like. Of these, the carboxyl protecting group and the amino protecting group are more preferred since they are commercially available that are 4-methoxybenzyl and benzylcarbonyl, respectively.
본 발명의 제조방법에 따라, 물, 이소프로판올, 및 메틸렌 클로라이드를 각각 1 : 3∼6 : 11∼14 의 비율(부피비)로 포함하는 혼합용매 중에서 반응을 수행할 경우, 하기 실시예에서 확인할 수 있는 바와 같이 화학식 1의 화합물을 입체선택적으로(즉, Z-이성체 및 E-이성체의 비율이 약 8.1 내지 15.7 : 1.0 의 범위를 갖도록) 제조할 수 있으며(표 1), 높은 수율 및 순도로 화학식 1의 화합물을 제조할 수 있다. 특히, 상기 혼합용매 중의 물, 이소프로판올, 및 메틸렌 클로라이드의 부피비가 1 : 4 : 12 일 경우, 높은 수율 및 Z/E 이성체 비율을 얻을 수 있다.According to the preparation method of the present invention, when the reaction is carried out in a mixed solvent containing water, isopropanol and methylene chloride in a ratio (volume ratio) of 1: 3 to 6:11 to 14, respectively, which can be found in the following examples Compounds of formula (1) can be prepared stereosterically (ie, such that the ratio of Z-isomers and E-isomers ranges from about 8.1 to 15.7: 1.0) as shown in Table 1 (Table 1), and in high yield and purity The compound of can be prepared. In particular, when the volume ratio of water, isopropanol, and methylene chloride in the mixed solvent is 1: 4: 12, high yield and Z / E isomer ratio can be obtained.
또한, 상기 혼합용매는 화학식 2의 화합물에 대하여 약 5 ∼ 20 배의 중량, 바람직하게는 약 10 ∼ 15 배의 중량을 사용하는 것이 바람직하다.In addition, the mixed solvent is preferably used about 5 to 20 times the weight of the compound of formula (2), preferably about 10 to 15 times the weight.
본 발명의 제조방법에 있어서, 상기 아세트알데히드는 화학식 2의 화합물 1 당량에 대하여 약 5 ∼ 30당량, 바람직하게는 약 10 ∼ 15당량을 사용할 수 있다. 또한, 본 발명의 제조방법은 약 -20 ℃ ∼ -10 ℃에서 수행할 수 있으며, 약 2 ∼ 20 시간, 바람직하게는 약 10 ∼ 15시간 동안 반응을 수행할 수 있다.In the preparation method of the present invention, the acetaldehyde may be used in an amount of about 5 to 30 equivalents, preferably about 10 to 15 equivalents, based on 1 equivalent of the compound of Formula 2. In addition, the production method of the present invention can be carried out at about -20 ℃ to -10 ℃, it can be carried out for about 2 to 20 hours, preferably about 10 to 15 hours.
상기 화학식 2의 화합물은 공지의 방법(예를 들어, 대한민국 특허공개 제2002-80838호)에 따라 제조할 수 있다. 즉, 하기 화학식 3의 3-할로메틸 세펨 화합물을 트리페닐포스핀과 반응시켜 포스포늄염을 제조한 후, 수산화나트륨 또는 탄산나트륨 등의 염기로 처리함으로써 화학식 2의 화합물을 제조할 수 있다.The compound of Formula 2 may be prepared according to a known method (for example, Korean Patent Publication No. 2002-80838). That is, the compound of formula 2 may be prepared by reacting a 3-halomethyl cefem compound of formula 3 with triphenylphosphine to prepare a phosphonium salt, followed by treatment with a base such as sodium hydroxide or sodium carbonate.
식 중, R1 및 R2는 상기에서 정의한 바와 같으며, X는 할로겐이다.Wherein R 1 and R 2 are as defined above and X is halogen.
또한, 상기 화학식 2의 화합물을 제조하는 단계 및 최종적으로 화학식 1의 화합물을 제조하는 단계는 화학식 2의 화합물을 별도로 분리함이 없이 동일 반응용기에서 수행할 수 있으며, 이 경우, 첫 번째 단계(즉, 화학식 2의 화합물을 제조하는 단계)에서 가한 염기가 반응액 중에 존재하므로 두 번째 단계(즉, 화학식 1의 화합물을 제조하는 단계)에서는 추가로 염기를 가할 필요가 없어 제조공정이 더욱 간단해 지게 된다.In addition, preparing the compound of Formula 2 and finally preparing the compound of Formula 1 may be performed in the same reaction vessel without separately separating the compound of Formula 2, in this case, the first step (ie Since the base added in the step of preparing the compound of Formula 2 is present in the reaction solution, the second step (that is, the step of preparing the compound of Formula 1) does not need to add additional base, thereby simplifying the manufacturing process. do.
상기 화학식 1의 화합물은 통상의 방법에 따라 보호기 제거반응을 수행함으로써 7-아미노-3-[프로펜-1-일]-3-세펨-4-카르복실산(화학식 4)을 제조할 수 있으 며, 이는 세프로질의 제조용 중간체로서 유용하게 사용할 수 있다.Compound of Formula 1 may be prepared 7-amino-3- [propen-1-yl] -3- cefe-4-carboxylic acid (Formula 4) by performing a protecting group removal reaction according to a conventional method It can be usefully used as an intermediate for the preparation of ceprozil.
이하, 본 발명을 실시예를 통하여 더욱 상세히 설명한다. 그러나, 이들 실시예는 본 발명을 예시하기 위한 것으로 본 발명의 범위를 제한하는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. However, these examples are intended to illustrate the invention and do not limit the scope of the invention.
실시예 1. 7-페닐아세트아미도-3-[프로펜-1-일]-3-세펨-4-카르복실산 p-메톡시벤질 에스테르의 제조 Example 1.Preparation of 7-phenylacetamido-3- [propen-1-yl] -3-cepem-4-carboxylic acid p-methoxybenzyl ester
3-클로로메틸-7-페닐아세트아미도-3-세펨-4-카르복실산 p-메톡시벤질 에스테르 50g (102.7mmol)에 소듐아이오다이드 16g, 트리페닐포스핀 28g을 반응기에 넣고 메틸렌클로라이드 400ml를 넣고 20℃에서 2시간 동안 교반하였다. 층 분리하여 얻은 유기층에 20% 수산화나트륨 용액 200ml을 적가하고 10℃에서 30분 동안 교반한 후, 유기층을 분리하여 포스포라닐리덴 용액을 얻었다.To 50 g (102.7 mmol) of 3-chloromethyl-7-phenylacetamido-3-cefe-4-carboxylic acid p-methoxybenzyl ester, 16 g of sodium iodide and 28 g of triphenylphosphine were added to a reactor and methylene chloride was added. 400 ml was added and stirred at 20 ° C. for 2 hours. 200 ml of 20% sodium hydroxide solution was added dropwise to the organic layer obtained by layer separation, stirred at 10 ° C. for 30 minutes, and the organic layer was separated to obtain a phosphoranilidene solution.
얻어진 용액에 메틸렌클로라이드 200ml, 이소프로판올 200ml, 물 50ml를 넣고 -20℃로 냉각한 다음, 아세트알데히드 100ml를 적가한 후 20시간 동안 교반하였다. 여기에 30% 티오황산칼륨을 적가하고 30분 교반한 후 유기층을 분리하였다. 얻어진 유기층에 이소프로판올 200ml를 적가한 후 농축하여 결정을 생성하였다. 0℃로 냉각하고 2시간 교반한 후 석출된 고체를 여과한 다음 진공건조하여 흰색의 고 체로 표제화합물 42.3g(88.4mmol, 수율86%, Z/E=10.1/1)을 얻었다.200 ml of methylene chloride, 200 ml of isopropanol, and 50 ml of water were added to the resulting solution, and the mixture was cooled to -20 ° C, and 100 ml of acetaldehyde was added dropwise, followed by stirring for 20 hours. 30% potassium thiosulfate was added dropwise thereto, stirred for 30 minutes, and the organic layer was separated. 200 ml of isopropanol was added dropwise to the obtained organic layer, followed by concentration to form crystals. After cooling to 0 ° C. and stirring for 2 hours, the precipitated solid was filtered and dried in vacuo to give 42.3 g (88.4 mmol, yield 86%, Z / E = 10.1 / 1) as a white solid.
H-NMR(δ, DMSO-d6): 1.52(3Hx10.1/11.1, d, (Z)-CH3), 1.73(3Hx1.0/11.1, (E)-CH3), 3.36-3.68(4H, m, phCH 2 , C-2), 3.75(3H, S, -OCH3 ), 5.06-5.24(3H, m, CO2-CH2, C-6), 5.52-5.69(2H, d, -CH=CH(CH3), 6.06(1H, d, -CH= CH(CH3), C-7), 6.91(2H, d, ph), 7.19-7.62(7.19-7.62(7H, m, ph)H-NMR (δ, DMSO-d 6 ): 1.52 (3Hx10.1 / 11.1, d, (Z) -CH 3 ), 1.73 (3Hx1.0 / 11.1, (E) -CH 3 ), 3.36-3.68 ( 4H, m, ph CH 2 , C-2), 3.75 (3H, S, -OCH 3 ), 5.06-5.24 (3H, m, CO 2 -CH 2 , C-6), 5.52-5.69 (2H, d , -CH = CH (CH 3 ), 6.06 (1H, d, -CH = CH (CH 3 ), C-7), 6.91 (2H, d, ph), 7.19-7.62 (7.19-7.62 (7H, m , ph)
실시예 2 및 3.Examples 2 and 3.
실시예 1에서 메틸렌클로라이드, 이소프로판올, 및 물의 부피를 하기 표1과 같이 변경시켜 사용한 것을 제외하고는 실시예 1과 동일한 방법으로 반응시켜 7-페닐아세트아미도-3-[프로펜-1-일]-3-세펨-4-카르복실산 p-메톡시벤질 에스테르를 제조하였으며, 각각의 수율 및 Z/E 이성체 비율은 다음 표1과 같다.7-phenylacetamido-3- [propen-1-yl was reacted in the same manner as in Example 1 except that the volume of methylene chloride, isopropanol, and water in Example 1 was changed as shown in Table 1 below. ] -3-cepem-4-carboxylic acid p-methoxybenzyl ester was prepared, each yield and Z / E isomer ratio is shown in Table 1.
상기 표1에서 확인할 수 있는 바와 같이, 본 발명에 따라 메틸렌클로라이드, 이소프로판올, 및 물의 혼합용매를 사용할 경우, 입체선택적으로 높은 수율로 화학식 1의 3-프로페닐 세펨 화합물을 제조할 수 있음을 알 수 있으며, 특히 메틸렌클로라이드, 이소프로판올, 및 물의 부피비가 12 : 4 : 1 일 경우 수율 및 순도 면에 서 가장 우수함을 알 수 있다. As can be seen in Table 1, when using a mixed solvent of methylene chloride, isopropanol, and water according to the present invention, it can be seen that the 3-propenyl cefem compound of Formula 1 can be produced in stereoselectively high yield In particular, when the volume ratio of methylene chloride, isopropanol, and water is 12: 4: 1 it can be seen that the best in terms of yield and purity.
실시예 4. 7-아미노-3-[프로펜-1-일]-3-세펨-4-카르복실산의 제조Example 4. Preparation of 7-amino-3- [propen-1-yl] -3-cefe-4-carboxylic acid
약 20℃의 반응기에 오염화인 22.8g과 메틸렌클로라이드 150ml, 피리딘 8.88ml를 넣고 30분 동안 교반하였다. 이 용액에 실시예 1에서 제조한 7-페닐아세트아미도-3-[프로펜-1-일]-3-세펨-4-카르복실산 p-메톡시벤질 에스테르 30g (62.6mmol)을 적가한 후 2 시간 동안 교반하였다. 반응 혼합물을 -10℃로 냉각한 다음, 1,2-프로판디올 30ml를 넣고 2시간 동안 교반한 후, 크레졸 120ml를 적가하고 2시간 동안 교반하였다. 반응혼합물에 증류수 200ml를 적가하고 1시간 동안 교반한 다음, 층분리하여 물층은 결정조로 보내고, 유기층은 2N HCl 300ml로 추출하여 결정조로 보냈다. 결정조에 30% 수산화나트륨 용액 200ml을 적가하여 결정화시킨 다음, 0℃로 냉각하고 석출된 고체를 여과한 후, 진공건조하여 미황색의 고체의 표제화합물 12g(50mmol, 수율 80%, Z/E=10.1/1)을 얻었다.22.8 g of phosphorus pentachloride, 150 ml of methylene chloride, and 8.88 ml of pyridine were added to a reactor at about 20 ° C. and stirred for 30 minutes. To this solution was added dropwise 30 g (62.6 mmol) of 7-phenylacetamido-3- [propen-1-yl] -3-cepem-4-carboxylic acid p-methoxybenzyl ester prepared in Example 1. After stirring for 2 hours. After the reaction mixture was cooled to -10 ° C, 30 ml of 1,2-propanediol was added thereto and stirred for 2 hours. Then, 120 ml of cresol was added dropwise and stirred for 2 hours. 200 ml of distilled water was added dropwise to the reaction mixture, stirred for 1 hour, the layers were separated, the water layer was sent to a crystal bath, and the organic layer was extracted with 300 ml of 2N HCl and sent to a crystal bath. 200 ml of 30% sodium hydroxide solution was added dropwise to the crystallization bath, and the mixture was cooled to 0 ° C., and the precipitated solid was filtered and dried in vacuo to give 12 g (50 mmol, 80% yield, Z / E = 10.1) as a pale yellow solid. / 1) was obtained.
H-NMR(δ, D2O+NaHCO3): 1.69과 1.88(3H, each, d, 6.0Hz, -CH=CH-CH 3 ), 3.38과 3.72(2H, Abq, 17Hz, H-2), 5.18(1H, d, 5.0Hz, H-6), 5.51(1H, d, H-7), 5.8(1H, m, -CH=CH-CH3), 6.06(1H, d, 11Hz, -CH=CH-CH3) H-NMR (δ, D 2 O + NaHCO 3 ): 1.69 and 1.88 (3H, each, d, 6.0 Hz, -CH = CH- CH 3 ), 3.38 and 3.72 (2H, Abq, 17 Hz, H-2) , 5.18 (1H, d, 5.0 Hz, H-6), 5.51 (1H, d, H-7), 5.8 (1H, m, -CH = CH- CH 3 ), 6.06 (1H, d, 11 Hz,- CH = CH-CH 3 )
본 발명에 따른 제조방법은 3-(Z)-프로페닐 세펨 화합물을 입체선택적으로 제조할 수 있으며, 상기와 같이 제조된 3-(Z)-프로페닐 세펨 화합물은 경구용 세팔 로스포린 항생제인 세프프로질의 제조에 유용하게 사용될 수 있다.The preparation method according to the present invention can stereoselectively prepare 3- (Z) -propenyl cefem compound, and the 3- (Z) -propenyl cefem compound prepared as described above is oral cephalosporin antibiotic Cef. It can be usefully used for the preparation of prozil.
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