KR100442123B1 - system for analyzing of nuclear magnetic resonance spectrometer - Google Patents

Abstract

1. TECHNICAL FIELD OF THE INVENTION

The present invention relates to an analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus.

2. Technical problem to be solved by the invention

The present invention, it is possible to obtain a more precise state of the material through a 200MHz class NMR spectroscopy device, and to provide an analysis system of the NMR spectroscopy device to contribute to the activation of the non-destructive diagnostic industry of the material In this,

3. Summary of the Invention Solution

In the analysis system of a nuclear magnetic resonance (NMR) spectroscopy apparatus, a low noise waveform is generated, including a pulse program capable of executing a pulse sequence at an accurate timing, and collecting and preprocessing detection data of magnetic resonance. Magnetic resonance analysis control means for performing control; RF signal transmission means for modulating an RF (Radio Frequency) pulse in synchronization with the pulse sequence from the magnetic resonance analysis control means, amplifying the modulated RF pulse and delivering the RF pulse to a high magnetic field RF probe of a nuclear magnetic spectrometer; RF signal receiving means for preamplifying and demodulating a nuclear magnetic resonance signal generated in said high magnetic field sample detected by said RF probe; And magnetic resonance analysis processing means for performing the editing operation of the pulse sequence through the built-in pulse sequence editor on the magnetic resonance data received from the magnetic resonance analysis control means.

4. Important uses of the invention

The present invention is applied to the analysis of materials by nondestructive

Description

System for analyzing of nuclear magnetic resonance spectrometer

The present invention relates to an analysis system of a nuclear magnetic resonance (NMR) spectroscopy apparatus, and more particularly, to a nuclear magnetic resonance (NMR) spectroscopy apparatus for determining the constituents of a substance by nondestructively analyzing chemical components of a substance tissue. Of the analysis system.

In general, nuclear magnetic resonance (NMR) spectroscopy for material composition analysis is based on superconducting magnets and detects nuclear material signals using RF coils in high magnetic fields. There is no need to worry, and it is widely used in physics, chemistry, biology, medicine, pharmacy, and materials engineering, and its application range is rapidly expanding. Nondestructive testing and analysis of microstructures are also possible, and because they use chemical and physical properties of tissues, they are widely used for nondestructive testing and analysis of chemical components.

First, the principle of NMR is briefly described as follows.

NMR measures how a nucleus of a material receives its energy and reacts after applying an RF pulse signal to the material. As shown in FIG. 1, the nuclei in which the spin is not zero have a magnetic moment μ in the external magnetic field, and the motion of the magnetic moment in the external magnetic field is represented by Equation (1).

Where Is the external magnetic field, μ is the magnetic moment,

Therefore, the magnetic moment (μ) of Equation 1 Around the axis Rotates at an angular velocity of. In this case, the magnetic moment is measured as one signal, and the measured signal is a vector sum of the magnetic moments (μ), which is called magnetization (M).

The size of the magnetization (M) is the external magnetic field ( ) Is proportional to the density of the nucleus and the direction is the same as the direction of the external magnetic field. This magnetization (M) receives RF energy Move toward the plane perpendicular to the axis. Then turn off the RF energy and magnetization (M) releases the energy and returns to its original state (equilibrium). The return process is different for each nucleus and under the influence of its surroundings. Therefore, it can be used to analyze the components of substances in NMR.

However, the analysis system of the conventional NMR spectroscopy has a problem that the signal detection using the RF frequency of several tens of MHz band is not accurate to detect the state of the precise material due to the signal detection.

Therefore, the present invention has been made to solve the above problems, it is possible to obtain a more precise state of the material through the 200 MHz class NMR spectroscopy, thereby contributing to the activation of the non-destructive diagnostic industry of the material It is an object of the present invention to provide an analysis system of the NMR spectroscopy apparatus.

1 is a view showing a measuring principle of a general nuclear magnetic resonance signal.

Figure 2 is an embodiment configuration of the analysis system of the nuclear magnetic resonance (NMR) spectroscopy apparatus according to the present invention.

3 is a detailed configuration diagram of an embodiment of the system controller shown in FIG. 2;

4 is a detailed block diagram of an embodiment of an RF modulator shown in FIG. 2;

FIG. 5 is a detailed block diagram showing an embodiment of the RF demodulator shown in FIG. 2; FIG.

6 is a detailed block diagram of an embodiment of a signal acquisition and processing unit shown in FIG.

7 shows the function of the pulse sequence editor of the analysis computer shown in FIG.

※ Explanation of code for main part of drawing

201: analysis computer 202: system controller

203: RF modulator 204: RF power amplifier

205: preamplifier 206: RF demodulator

212: RF probe 220: nuclear magnetic resonance (NMR) spectroscopy apparatus

The apparatus of the present invention for achieving the above object, in the analysis system of the nuclear magnetic resonance (NMR) spectroscopy apparatus, including a pulse program capable of executing the pulse sequence at an accurate timing and generates a low noise waveform Magnetic resonance analysis control means for collecting magnetic resonance detection data and performing preprocessing control; RF signal transmission means for modulating an RF (Radio Frequency) pulse in synchronization with the pulse sequence from the magnetic resonance analysis control means, amplifying the modulated RF pulse and delivering the RF pulse to a high magnetic field RF probe of a nuclear magnetic spectrometer; RF signal receiving means for preamplifying and demodulating a nuclear magnetic resonance signal generated in said high magnetic field sample detected by said RF probe; And magnetic resonance analysis processing means for performing the editing operation of the pulse sequence through the built-in pulse sequence editor on the magnetic resonance data transmitted from the magnetic resonance analysis control means.

Hereinafter, with reference to the accompanying drawings, a preferred embodiment of the analysis system of the nuclear magnetic resonance (NMR) spectroscopy apparatus according to the present invention will be described in detail.

Figure 2 is an embodiment configuration of the analysis system of the nuclear magnetic resonance (NMR) spectroscopy apparatus according to the present invention.

As shown in FIG. 2, the analysis system includes an analysis computer 201, a system controller 202, an RF modulator 203, an RF power amplifier 204, and an RF probe 212. A preamplifier 205 and an RF demodulator 206.

The system controller 202 generates a low noise waveform including a pulse program capable of executing the pulse sequence at an accurate timing, and transmits the pulse sequence to the RF modulator 203, from the RF demodulator 206. The detection data of the received magnetic resonance are collected and transferred to the analysis computer 201 by performing preprocessing control.

The RF modulator 203 modulates an RF pulse in synchronization with a pulse sequence transmitted from the system controller 202, and transmits the modulated RF pulse to the RF power amplifier 204.

The RF power amplifier 204 amplifies the RF pulse received from the RF modulator 102 and delivers the RF pulse to the RF probe 212 in the high magnetic field 220.

The RF probe 212 transmits the amplified RF pulse, detects the nuclear magnetic resonance signal generated from the sample in the high magnetic field 220 and delivers the nuclear magnetic resonance signal to the preamplifier 205. The preamplifier 205 amplifies the nuclear magnetic resonance signal detected by the RF probe 104 and transmits the amplified nuclear magnetic resonance signal to the RF demodulator 206. The RF demodulator 206 demodulates the nuclear magnetic resonance signal amplified by the preamplifier 205 and transmits the demodulated nuclear magnetic resonance signal to the system controller 202.

The system controller 202 collects and detects the magnetic resonance detection data received from the RF demodulator 206 and transmits the detected data to the analysis computer 201. The analysis computer 201 performs the editing operation of the pulse sequence through the built-in pulse sequence editor on the magnetic resonance data received from the system controller 202. Here, the editing operation will be described in detail with reference to FIG. 7 which will be described later to perform editing through control of time, shape, level, gate, phase, and the like.

3 is a detailed block diagram of an embodiment of the system controller shown in FIG. 2.

As shown in FIG. 3, the system controller 202 detects the energy emitted from the nucleus excited by the RF pulse inside the magnet of the high magnetic field through the RF probe 212, and the AF (Audio) in the RF demodulator. It demodulates the frequency band and controls the entire process of converting A / D converter into digital data and peripheral system. In addition, the system controller 202 should have high-precision time control, low noise waveform generation, high resolution data acquisition and preprocessing functions, and suitable for jump, loop, load, etc. It should be possible to execute the designed microcomputer language sequentially.

That is, the system controller 202 includes a host interface 301, a time controller 304, a memory 302, and a signal acquisition and processing unit 303 to perform the above functions.

The host interface 301 uses a National Instruments AT-DIO32F (32-bit high-speed digital input / output board) for high speed data communication between the system controller 202 and the analysis computer 201. Implemented the interface.

Here, the high speed digital input / output board (AT-DIO32F) can use four 8-bit (BIT) ports (DIOA, DIOB, DIOC and DIOD), and port A and port B are handshaking. It is assigned to group 1, and port C and port D are assigned to group 2. Each group can be used as an input or output port, respectively.

The time controller 304 is a 32-bit time control circuit. When the edited item on the host computer is converted into an electronic language using a sequence compiler, a gate, ± X, ± Y, RF, etc. In order to precisely maintain the control signal for the edited time, a high precision time control circuit and a register latch circuit are required.

That is, the time controller 304 defines a time of about 500 ns as the minimum pulse time and a maximum time of 100 ns x 2 ^ 32 based on the minimum pulse application time mainly used in the nuclear magnetic resonance signal measuring system. Was designed.

Here, the microsequence program produced on the host computer for measuring the signal is transmitted to the system controller 202 via the AT-DIO32F interface circuit of the host interface portion. At this time, when the start command of the pulse sequence program is performed by the user, the time controller 304 generates an overflow signal after counting the time for the holding time of the given bit pattern. Fetch a new command for.

Here, the time controller 304 shows an example of a 32-bit time control circuit using a cascade connection of 74F193, PD [0..31] data bus is a bus for transmitting the instruction duration to be performed next, H2 is the clock of the system and XOVF is the last overflow signal of the count. It is used as a signal to trigger the patch of the next instruction.

The memory 302 should implement three memory interfaces. First, a shared memory for communication between the system controller 101 and the host computer should be configured, the system memory of the Texas Instruments Co. Digital Signal Processor (TMS320C31) used as the main processor, and finally the sequence for storing the sequence program. The interface design of the program memory is required.

First, the shared memory interface for communication between the system controller 202 and the analysis computer 201 can transmit and receive data of up to 8K words at a time using the Integrated Device Technology Co. 8K x 16 dual port memory (IDT7025). To make it possible. The system memory of the system controller 202 is designed using KM6161002 (SAMSUNG Co. 32K x 16 Bit Fast Static RAM), and the sequence program memory is also IDT7025, and the right port is connected to the main processor in the system. The program can be changed by allowing direct read / write, and the remaining left port is used as output port.

Here, the memory control and interface circuits are all integrated in the CPLD of Xilinx to simplify the external PCB circuit.

The signal acquisition and processing unit 303 is for acquiring and processing a pulse signal for measuring a nuclear magnetic resonance signal generated from a sample.

That is, the nuclear magnetic resonance signal generated by applying RF energy to excite the nucleus of the sample in the magnetic field is detected through the RF coil of the RF probe 212, and the detected nuclear magnetic resonance signal is a preamplifier ( In 205). In addition, the first amplified nuclear magnetic resonance signal is demodulated in the real part and the imaginary part in the RF demodulator 206 to be transformed into an envelope signal in the audio-frequency region, and the signal is finally The A / D converter of the signal acquisition and processing unit 303 is converted into a digital signal.

The frequency synthesizer generates a carrier frequency to be used in the demodulation circuit to detect the magnitude in the nuclear magnetic resonance signal determined according to the Lamor Equation by the strength of the magnetic field, and the phase used during transmission in the intermediate frequency generator. Two orthogonal sine waves of the same signal containing the information are generated, and the demodulator uses the signals of these three systems to finally detect the magnitude of the nuclear magnetic resonance signal.

After that, it passes through two channels of A / D converters. The 8K first-in first-out memory (FIFO: First) is composed of processor independent to acquire and store the signal of bandwidth defined in the pulse sequence for a given time. A / D converter with up to 2.5MHz sampling rate with Buffer Memory, Low distortion input filter and amplifier is used.

In addition, pre-processing such as signal averaging, base line correction, and phase correction is performed on the nuclear magnetic resonance signal converted through the A / D converter to a digital value. processing).

In addition, a digital signal processing system equipped with Texas Instruments Co. Digital Signal Processor (TMS320C44) was used for high-speed acquisition and real-time signal processing.

The TMS320C44 digital signal processor uses the looping and jump instructions for iterative operation and the inter-lock operation for simultaneous operation to implement a floating point arithmetic signal processing system. By having an extended and optimal instruction structure such as Locked Operation, it is possible to guarantee the optimal operation structure when implementing algorithms for signal processing such as fast Fourier transform, convolution and digital filtering.

In particular, the TMS320C44 provides two methods to implement parallel distributed processing. First, in the Bus Architecture, a shared bus can be easily implemented by implementing a Global Bus and a Local Bus, and an 8-bit parallel communication port is provided in the case of the TMS320C40. Six are built into the TMS320C44, which is very useful when designing parallel processing systems. It has a 32-bit timer, DMA controller, 32-bit barrel shifter, floating point / integer multiplier, and accumulator.

4 is a detailed block diagram of an embodiment of the RF modulator shown in FIG. 2.

As shown in FIG. 4, the RF modulator A includes an intermediate frequency amplifier 410, a phase modulator 420, and an RF signal processor 430.

The intermediate frequency amplifier 410 includes an intermediate frequency processor 402 and a low noise amplifier 404. The phase modulator 420 includes a phase separator 412, a first mixer 414, a second mixer 416, and a phase combiner 418, and the RF signal processor 430 includes a third mixer 432. ) And a fourth mixer 434.

The intermediate frequency processor 402 processes the IF frequency of 10.7Mhz by the pulse signal provided from the system controller 202 and transmits it to the low noise amplifier 404. The low noise amplifier 404 low noise amplifies the transmitted intermediate frequency signal and delivers it to the phase separator 412.

The phase separator 412 separates the low noise amplified intermediate frequency into 0 ° and 90 ° phases, the phase of 0 ° is transmitted to the first mixer 414, and the 90 ° phase is the second mixer 416. To pass). Here, the output of the phase separator 412 is 3 dB away from the input, it is preferable to connect the amplifier to the output terminal.

The first mixer 414 phase modulates an intermediate frequency of 0 ° with a control signal of X pulses and provides it to the phase combiner 418. The second mixer 405 also phase modulates an intermediate frequency of 90 [deg.] By the Y pulse control signal to the phase combiner 418.

The phase combiner 418 phase-couples the modulated intermediate frequency to the third mixer 432. The third mixer 432 combines the phase-coupled intermediate frequency by using a transmission pulse gate and transfers the combined intermediate frequency to the fourth mixer 434.

Here, the transmission pulse gate controls the output signal by the time set in the pulse sequence by the pulse program.

The fourth mixer 434 multiplies the intermediate frequency coupled from the third mixer 432 by the signal of the frequency (210.5 MHz) output by the frequency synchronization, so that a signal of two components, 200 MHz and 221 MHz, is passed through the low pass filter 436. )

The low pass filter 409 filters the 221 MHz frequency by a filtering operation, and finally outputs only the 200 MHz frequency to the RF power amplifier 204.

Accordingly, the signal amplified by the RF power amplifier 204 is applied to the RF probe 212 through the antenna.

FIG. 5 is a detailed configuration diagram of an embodiment of the RF demodulator shown in FIG. 2.

As shown in FIG. 5, the RF demodulator 206 includes a filter unit 510 and a phase demodulator 520.

The filter unit 510 includes a first mixer 502, a first low pass filter 504, and an amplifier 503, and the phase demodulator 520 includes a phase separator 512 and a second mixer 513. ), A third mixer 514, a second low pass filter 515, and a third low pass filter 516.

The first mixer 502 receives the 200 MHz + ΔF signal detected by the RF probe 212 through the preamplifier 205, and combines the received 200 MHz + ΔF frequency with 200 MHz-IF to provide a predetermined signal. The intermediate frequency is output, and the output intermediate frequency is applied to the first low pass filter 504. The first low pass filter 504 removes unnecessary frequencies from the applied intermediate frequency and passes only the desired frequency to the amplifier 506.

The amplifier 506 amplifies the intermediate frequency received from the first low pass filter 504 to a predetermined level and transfers the amplified frequency IF + ΔF to the phase separator 512.

The phase separator 504 separates the received intermediate frequency IF + ΔF into 0 ° and 90 ° phases, transfers the phase of 0 ° to the second mixer 513, and the 90 ° phase is a third phase. Transfer to mixer 514. In this case, if the intermediate frequency of 0 ° phase is called I and the intermediate frequency of 90 ° phase is Q. The I and Q signals are multiplied by the output 200 MHz of the frequency synthesizer by the second mixer 513 and the third mixer 514, respectively.

Therefore, the intermediate frequency output from the second mixer 513 is transferred to the second low pass filter 515, and the intermediate frequency output from the third mixer 514 is transferred to the third low pass filter 516.

In this case, the signals input to the second low pass filter 515 and the third low pass filter 516 are output at 400 MHz + ΔF and ΔF, respectively, but the signal we need is a signal of ΔF. As a result, only the signals of I (ΔF) and Q (ΔF) are finally output. Accordingly, the final output I and Q signals are converted into digital signals through the A / D converter of the system controller 202 to perform signal processing.

FIG. 6 is a detailed block diagram of an embodiment of the signal acquisition and processing unit illustrated in FIG. 3.

As shown in FIG. 6, the signal acquisition and processing unit includes a data acquirer 601, a baseline corrector 603, a phase corrector 605, and a fast Fourier transformer 607.

That is, the waveform generated by the pulse sequence editor (described in detail in FIG. 7) of the analysis computer 201 is applied to the magnet through the system controller 202, the RF modulator 203, and the RF power amplifier 204. When the generated resonance signal is detected through the RF probe 212, the detected resonance signal is signal processed and input to the signal acquisition and processing unit 303. In this case, the signal acquisition and processing unit 303 not only obtains a resonance signal but also performs a function of processing the signal.

The baseline corrector 603 removes the DC value of the signal acquired by the data acquirer 601 when there is an offset, and transfers only the AC component of the signal to the fast Fourier transformer 607.

The phase corrector 605 changes the phase of the signal acquired by the data acquirer 601 and transfers the changed data to the fast Fourier transformer 607.

The fast Fourier transformer 607 converts the data input by the Fast Fourier Transform (FFT) algorithm from the time domain to the frequency domain and transfers the data to the analysis computer 201.

Here, the data acquisition unit 601 outputs the data obtained by the control signal provided from the analysis computer 201 through the baseline corrector 603, or through the phase corrector 605, or the baseline. The data may be output through the compensator 603 and the phase compensator 605, and the acquired data may be directly transferred to the fast Fourier transformer 607.

FIG. 7 is a diagram illustrating a detailed editing function of the pulse sequence editor embedded in the numerical computer shown in FIG. 2.

When using timer control, the timing of the start of an event controlled by the system controller 202 is from the time the event item is placed, and the duration of the event is specified in time. . In some cases, a fixed value may be used, and an input control set may be set in which only an initial value may be specified and a variable time may be input during execution. If you specify a value of 0 for this item, all events in the same column are ignored (Read-back, Marker Lable, etc. used during compilation) are valid.

Shape Control is where you can set the waveform. Generally, a predefined sampling table is used to define the waveform. In the case of RF type, a sin waveform for slice selective exitation is used, and in the case of gradient, a slope table considering the rise time of a gradient amplifier is defined.

Level (Amplitude) Control is used to substantially control the amplitude of the waveform. That is, the level control signal input through the analysis computer 201 is transmitted to the RF modulator 203 through the D / A converter of the waveform generator built in the system controller 202.

Here, the digital input is a form in which the amplitude of the 16-bit resolution is multiplied and output like the 16-bit signal related to the waveform. As a result, the value output from the MDAC (Multiflying DAC) has a 32-bit value, and the output value is written over time.

The waveform generator has three RF channels, three gradients X, Y, and Z for spatially selective excitation, and there are eight control elements associated with the waveform in the software produced.

Gate control is a control that has a setting of ON or OFF. A typical example is the gate of the RF output. In this case, the final stage of the spectrometer determines whether to output the RF waveform.

The phase control uses a phase modulation method so that an error does not accumulate during refocusing even when an accurate flip angle is not implemented in the MRI pulse sequence. In order to implement pulse modulation, it is possible to set the basic phase of + x, + y, -x, -y and other phases. It must be set in advance before the gate of the RF is ON, and once changed phase is latched and valid until the next change.

The acquisition control acquires a signal according to a frequency and a sampling point set in a global parameter. The acquisition control element sets the receive data and the receive phase simultaneously.

The processor read-back is used for the purpose of checking the progress of the sequence while the pulse sequence is in operation, and is a control element that plays an important role in updating the output waveform.

Loop control can set anchor point and jump point. Loops are set up when repetitive execution of the pulse sequence is required to improve readability and reduce repetitive editing. The anchor point may give a user an arbitrary name and may give parameters such as the name of the target anchor and the number of interval repetitions at the jump point.

The analysis system may be used for chemical sample analysis, MRI imaging device development, fruit sugar measurement, medical diagnostic basic system application, non-destructive diagnostic system application, imaging system application, chemical and dangerous goods detection, and the like.

As mentioned above, preferred embodiments of the present invention are disclosed for the purpose of illustration, and those skilled in the art can improve and change various other embodiments within the spirit and technical scope of the present invention disclosed in the appended claims below. , Replacement or addition would be possible.

The analysis system of the nuclear magnetic resonance (NMR) spectroscopy apparatus according to the present invention as described above is able to obtain a more accurate state of the material through the 200 MHz class NMR spectroscopy, thereby It is a very useful invention that can contribute to activation.

Claims (7)

In the analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus, System control means for generating a low noise waveform including a pulse program capable of executing the pulse sequence at an accurate timing, and collecting and preprocessing control data of detection of magnetic resonance; RF signal transmission means for modulating an RF (Radio Frequency) pulse in synchronization with the pulse sequence from the system control means, amplifying the modulated RF pulse and delivering the RF pulse to a high magnetic field RF probe of a nuclear magnetic spectrometer; RF signal receiving means for preamplifying and demodulating a nuclear magnetic resonance signal generated in said high magnetic field sample detected by said RF probe; Magnetic resonance analysis means for performing the editing operation of the pulse sequence through the built-in pulse sequence editor of the magnetic resonance data received from the system control means Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method of claim 1, System control means, Interface means for performing a connection for high speed data communication with the magnetic resonance analysis processing means; Time control means for controlling a pulse application time for analysis of the nuclear magnetic resonance signal; Analysis storage means for storing communication between the system control means and the magnetic resonance analysis processing means, processing of the system control means, and storing of the sequence program; And Signal acquiring and processing means for acquiring and processing a pulse signal for measuring the demodulated nuclear magnetic resonance signal received by the RF signal receiving means Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method of claim 1, The RF signal transmission means, RF variation means for modulating an RF pulse in synchronization with a pulse sequence transmitted from the magnetic resonance analysis processing means; And RF power amplification means for amplifying the RF pulse modulated by the RF modulation means for delivering to the RF probe in the high magnetic field 220 of the magnetic resonance analyzer Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method according to claim 1 or 3, The RF modulation means, Intermediate frequency amplifying means for low noise amplification by processing at an intermediate frequency by a pulse signal provided from the system control means; Phase modulation means for separating the low noise amplified intermediate frequencies into 0 ° and 90 ° phases in the intermediate frequency amplifying means, and modulating and combining the separated intermediate frequencies of 0 ° and 90 °, respectively; RF signal processing means for signal-processing the high frequency generated by using the transmission pulse gate to the intermediate frequency coupled and phase-modulated by the phase modulation means through filtering Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method of claim 1, The RF signal receiving means, Preamplification means for receiving and preamplifying the magnetic resonance signal detected by the RF probe in the sample; And RF demodulation means for demodulating the preamplified magnetic resonance signal through filtering and phase separation Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method according to claim 1 or 5, The RF demodulation means, Intermediate frequency processing and filtering means for intermediate frequency processing the pre-amplified magnetic resonance signal in the preamplification means and removing unwanted frequencies; And The intermediate frequencies from which the unnecessary frequencies have been removed by the intermediate frequency processing and filtering means are separated into different phases, and the intermediate frequencies separated by the different phases are detected by the output of each frequency synthesizer and the mixer and filtering, respectively. Phase demodulation means for delivery to system control means Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a. The method of claim 2, The signal acquisition and processing means, Data acquiring means for converting and acquiring a magnetic resonance signal input from the RF signal receiving means into a digital form; Baseline correction means for extracting only an AC component by removing a DC value when there is an offset in the magnetic resonance signal obtained by the data acquisition means; Phase correction means for changing the phase of the magnetic resonance signal obtained by the data acquiring means and the magnetic resonance signal corrected by the baseline correction means; And Magnetic resonance is obtained by converting one of a magnetic resonance signal obtained from the data acquiring means, a magnetic resonance signal corrected by the baseline correction means and a magnetic resonance signal phase corrected by the phase correction means from a time domain to a frequency domain. Fast Fourier Transform Means for Transfer to Analytical Processing Means Analysis system of nuclear magnetic resonance (NMR) spectroscopy apparatus comprising a.