KR100360586B1 - Injection device for mixing two compounds - Google Patents

Abstract

The present invention relates to an injection device for mixing two compounds, the present injection device according to a preferred embodiment includes a potion bottle (10) having an inlet and a stopper having a penetrating central portion; A tube 14 "" is provided for guiding the injection end of the syringe 12 during the movement of the syringe between the first so-called storage position and the second insertion position, the guide tube receiving the injection end of the syringe. The second end is provided, the second end is provided with a sealing member 274 between the syringe body and the guide tube.

Description

Injection device for mixing two compounds

Brief description of the invention

The present invention relates to an injection device, which is capable of injecting a mixture by mixing two compounds, and more particularly, a device in which two compounds to be mixed are stored in separate form before injection. .

Generally in the medical field, there are drugs that must be separated and stored until they are injected into the patient, for example, by subcutaneous injection, intravenous injection, and intramuscular injection, in which case the drugs are particularly freeze-dried. It is prepared in the form of a powder or powder and dissolved in a solvent such as a physiological saline solution and injected into the patient.

On the other hand, in some cases, it is a liquid that cannot be stored for a long time in a mixed state of two compounds to be mixed.

In such cases, the most frequently used solutions are closed by a leaky membrane that can penetrate the needle and use a method of storing the powder in a separate container, in which case any amount of solvent is used using an injection device. Is extracted from the second container, injected into the first container through the membrane film, mixed in the first container, the mixture is aspirated by the same injection device, and used for actual injection.

The solution described above has a number of drawbacks, first of which must use a container closed by an injection device and a penetrating membrane, a second container containing a syringe and a solvent, which are separate articles and, in addition, handling operations are quite significant. On the other hand, there is a drawback of complexity, and on the other hand there is a defect that is difficult to maintain sterility during various processing operations of two components.

On the other hand, the freeze-dried device is preferably in the form of a glass container as described above, in view of the fact that a standard glass container with a flat outer bottom is used. It is preferable to have. In addition, since recent drugs already have the form described above, any modifications to the packaging must be approved by a new, long and costly stability study.

In addition, it is essential to ensure that the needles are not exposed during the storage period and preferably during the treatment operation, which corresponds to the mixing of the drug.

Therefore, the present invention is to provide an injection device for receiving each of the two compounds in two separate containers to mix these compounds to inject to the patient, the present invention is preferably a standard medicine bottle One of two compounds in the first vessel is freeze-dried separately from the sterilization of the solvent in the second vessel under conditions similar to those which freeze-dried the drug contained therein. In addition, the present invention is manufactured as a single piece of easy-to-operate assembly to ensure that during storage, the complete sterile state of the various parts of the device that can be in contact with the patient or the drug injected into the patient is maintained, and the needle is in perfect sterile state. It is another object of the present invention to provide an injection device which enables the carrying out of a treatment operation for mixing two drugs while maintaining.

In order to achieve the above object, the injection device according to the present invention, which can mix two kinds of compounds in which at least the first compound is a liquid, is provided with a syringe with an injection end, and the syringe is provided with the first compound. It will be provided with the means described below while receiving,

And means for guiding the injection end of the syringe back and forth between the so-called storage position, the first position for withdrawal, and the so-called operating position, the injected second position, wherein the guide means comprises a potion bottle for containing one of the compounds. A first end projecting opposite the pierceable portion of the stopper that can block the inlet of the mouth, and a second end for receiving the injection end of the syringe, the second end mounted to the guide member side. Sealing means for interacting with an outer face of the syringe and means for maintaining sufficient engagement during the longitudinal movement between the syringe and the guide member,

And when the injection end of the syringe is in the second position, communication means are provided to allow the contents of the syringe to communicate with the interior of the vial as well as to allow penetration of the fraud-permeable portion.

Preferably, the potion is integral with the injection device, but a syringe in which the guide is provided separately from the potion bottle and the two assemblies are continuously connected is also within the scope of the present invention.

It is also preferred that the first sealing means provide a dynamic seal between these guides and the syringe body during the relative displacement of the guide and the syringe body.

Preferably, the first end of the guide portion is provided with a connecting means for connecting to the upper portion of the inlet of the potion bottle.

In addition, the present invention preferably comprises a single assembly consisting of a pill bottle containing a freeze-dried product, and a syringe containing a solvent, the pill bottle and the syringe is connected by the guide means to assist the mixing action and to the sealing means The needle is protected from the risk of contamination during storage.

According to a first embodiment, the communicating means has a needle mounted at the injection end of the syringe, the end of which can penetrate the central region of the stopper when the syringe end is located in the second position.

As described above, the needle performs two roles, and serves to enable communication between the inside of the syringe body and the potion bottle, and the syringe once separated from the potion bottle serves as a conventional syringe needle.

Also preferably, the injection device is provided with a penetrating end extending around the entire length of the needle and extending behind the end of the needle and having a removable needle protection member for the needle, wherein the first of the needle protection members Potion bottle cap is penetrated by the end.

According to a second embodiment of the invention, the communication means has a tubular member provided between the central region of the stopper and the injection end of the syringe, the tubular member having a first end capable of closing the central part of the stopper, And a second end that penetrates the permeable membrane in the injection end of the syringe when placed in the second position.

In the second embodiment, the tubular member is provided with two through ends to penetrate the stopper of the potion bottle and the permeable membrane of the syringe when the syringe is inserted into the guiding means, such that the two compounds are mixed. And preferably the pierceable membrane is itself a pierceable plug which closes the syringe. And this is also the case when the torso provided with a penetrating stopper is installed in the syringe.

Further preferably, the guide means is further provided with a second sealing means for limiting communication means in the guide means together with the first sealing member.

Also preferably, the guide means is provided with an orifice closed by a sterile microporous filter between its first and second ends.

In this case, it is possible to take two advantages by providing the filter, one of which allows a part of the air contained in the guide means to pass through, thereby facilitating displacement of the syringe in the guide means while maintaining a sterile state during storage in the guide means. Another is that the sterile gas is guided through the filter after the guide means is fixed to the potion bottle.

The injection device is also preferably equipped with an autoinjector which is mounted on the syringe / guide part assembly after the syringe / guide part assembly has been separated from the potion bottle. The automatic scanning device includes a support, a means for fixing the guide part so as not to translate, a first pressurizing part for allowing the syringe to be inserted into the guide part at a first predetermined distance, and a plunger of the syringe at a second predetermined distance to the syringe body. A second pressing portion is provided to allow insertion into the first portion of the guide part to form a surface facing the body of the patient without changing the position of the syringe body.

The first pressing portion serves to insert the needle into the patient's body at a predetermined distance while the second pressing portion is used to perform the injection of the mixture.

Also preferably, the injection device is further provided with an annular protective means surrounding a portion of the body of the syringe to prevent hand contact with a portion of the outer surface of the syringe body, while the syringe is in the first position of the guide means. The first end of the protective means is adjacent to the first sealing member, and the axial length 1 between the first and second ends of the protective means is between the first and second positions of the syringe in the guide means. Is at least equal to the axial running distance 1 '.

On the other hand, according to another embodiment, when the syringe is displaced between the first and second positions, the sealing member is provided with temporary connecting means for connecting with the syringe body during movement, in which case the sealing lip is externally provided. And interact with the guide component.

According to another embodiment, the first sealing member is formed integrally with the syringe body portion, and further preferably, the syringe body is provided with a body portion at the fixed end of the plastic adapter on which the syringe needle is mounted. The adapter is provided on its outer surface with at least one annular lead which interacts with the inner surface of the guiding means to create a dynamic sealing member.

And according to another aspect of the invention, the guiding means is preferably provided with a chamber for confining the gases that can leak from the potion when the needle is extracted from the potion bottle.

Other features and advantages of the present invention will now be described with reference to the accompanying drawings, in some embodiments in accordance with the present invention:

1 is a longitudinal sectional view of an injection device in a storage position according to the first embodiment,

2 is a longitudinal cross-sectional view of an injection device similar to that of FIG. 1 at the location of mixing the compounds.

3 is a longitudinal sectional view of the injection apparatus according to the second embodiment in the storage position,

4 is a longitudinal cross-sectional view of an injection device similar to that of FIG. 3 at the position where the compounds are mixed;

5 is a longitudinal sectional view of the injection apparatus according to the third embodiment,

6 is a partial cross-sectional view in the longitudinal direction of the injection device according to the fourth embodiment including a modified type potion bottle,

7a, 7b and 7c is a vertical cross-sectional view of the guide component according to another modified embodiment and a cross-sectional view on the line BB of FIG. 7a and a state diagram coupled to the potion bottle,

8a to 8c are longitudinal cross-sectional views of different embodiments of the injection device,

9a and 9b are cross-sectional views of two different embodiments of a guide component with a pleated capsule,

9c is a sectional view of an injection device provided with a guide component according to FIG. 9b,

10a to 10d are cross-sectional views showing the use of the autoinjector with the injection device,

11A-11C are similar to FIGS. 8A-8C, but cross-sectional views of different embodiments,

12 is a vertical sectional view of a different embodiment of the injection device,

13 is a longitudinal sectional view showing different embodiments of the sealing means between the syringe and the guide part and different embodiments of the injection device,

14a is a longitudinal sectional view of a variant embodiment of the injection device according to FIG. 12;

14B and 14C are detailed views of FIG. 4A, which are cross-sectional views of the sealing member in the storage position and the operating position,

15 is a sectional view of a first embodiment of a gas limited chamber,

16A and 16B are cross-sectional views of two different embodiments of gas limited chambers,

17 is a cross-sectional view of a modified embodiment of the injection device for limiting gas,

Figure 18a is a partial cross-sectional view of the injection device according to the embodiment in which the extraction of the syringe from the outside of the guide component is controlled,

FIG. 18B is a partial vertical sectional view of the sealing member according to FIG. 18A.

First, a first embodiment of an injection apparatus will be described in detail with reference to FIG. The first embodiment of the injection device here basically consists of a potion bottle 10, a syringe 12, and a guide sleeve 14 mounted on the potion bottle 10, which will be described in more detail. The potion bottle 10, which is designated 16 and preferably contains a first compound to be mixed, which is a freeze-dried compound, preferably has an inlet 18, which is finished with a joint ring 20, which is inlet 18. ) Is filled with a stopper 22 of a standard type. In addition, the stopper 22 is made of a material which is penetrable and can be firmly connected to the joint 20 of the potion bottle by the aluminum capsule 23 except for the central part of the stopper, that is, the penetrable area. Is made.

Preferably, the stopper 22 is provided with a cylindrical body 24 for interacting with the inlet 18 of the potion bottle 10, the cylindrical body 24 is provided with an axial inlet 26, The passage 24 allows the gas to circulate during the freeze-drying operation when the stopper is partially coupled to the inlet of the potion bottle, while the passage 24 provides complete closure when the stopper is fully inserted.

On the other hand, in the present embodiment, the guide part 14 is preferably cylindrical in shape, and is provided with a first end having a flange 28 to be fixed on the stopper 22 and the joint ring 20 of the potion bottle. The coupling between the guide part 14 and the potion bottle 10 during the movement. The diameter of the guide part is slightly larger than the diameter of the body 30 of the syringe 20, and as in the conventional apparatus, the body of the syringe 30 ends with an injection end 32 on which the needle 34 is mounted.

In the embodiment shown in FIG. 1, the needle is protected by a cap 36, the end 38 of which is interleaved with the injection end 32 of the syringe in an intact manner and the second of the cap. The end 40 extends into a cylindrical washer that is penetrable and that interacts with a circular groove 44 made in the fixed flange 28 of the guide component 14. The end 40 of the protective cap 36 therefore does not move during movement and is flat compressed against the pierceable portion 22 of the stopper of the potion bottle 10. In addition, the washer 42, the outer circumference of which is fixed between the outer circumference of the stopper of the potion bottle and the groove 44, covers the permeable portion of the stopper so that it does not leak, and the end of the guide part 14 is sealed. As will be described below, other shapes of needle protection members may be used. In addition, the open end 46 of the guide part 14 is provided with an inner sealing member 48 around the circumference of the guide part 14 to maintain the seal during movement and at the same time to allow the displacement of the syringe in the guide part 14. And a seal between the body 30 of the syringe. In order to provide the sealing member as described above, it is preferable that the rubber sealing member is provided in a ring shape, and further preferably, three sealing lips 49 'are provided on the inner surface of the guide part. In addition, the length of the ring 1 along the direction of displacement of the syringe is sufficient to ensure sufficient engagement of the syringe with the guide component 14 while at the same time allowing displacement of the syringe with respect to the guide component under the influence of the force applied to the syringe. The above length 1 here is, for example, 1 cm. In addition, the length of the sealing member helps to maintain the guide part and the syringe body in the concentric position during the displacement of the syringe. Preferably, the sealing member 48 forms a retractable inner shoulder portion 49 which limits the insertion of the syringe into the guide component when the injection device is stored.

In addition, as shown in FIG. 1, the second shoulder portion 50 is preferably provided inside the guide part 14 to limit the possibility of insertion of the syringe 12 into the guide part 14. In this way, when the shoulder portion 50 is partitioned so that the end portion of the syringe is adjacent to the shoulder portion, the end portion of the needle 34 passes through the central portion 22 of the stopper, but only slightly protrudes into the potion bottle 10 to generate a mixture in the potion bottle. In the case of suctioning in the vertical position with the aid of the needle to return the needle to its original position, the capacity loss in the potion bottle is limited to the maximum possible. As a result, as in conventional syringes, the syringe 12 has a plunger 52 mounted to slide in the body of the syringe, the plunger 52 having an interior into which an adjustment rod, which is a push rod of the plunger 52, is fixed therein. A scrubbing screw 54 is provided. In the storage position, the second compound to be mixed is provided in the volume 56 of the body of the syringe 12.

In a different embodiment, the open end 46 of the guide component 14 extends into a conical splinter 51 that is flaring in the shape of a morning glory. The purpose of this joint is to protect the finger of the operator holding the guide component during recovery of the syringe in place within the guide component after insertion into the patient. The joint ring 51 can here be replaced by another form which protrudes from the outer surface of the guide component, which is placed on the opposite side of the end 46 where the syringe is reinserted into it after use of the syringe. It is obvious that the operator's finger can be protected.

According to another variant embodiment, the clip flange 28 of the guide part extends around the entire outer circumference of the stopper 22, and by forcing it to fix the outer circumference of the stopper 22 on the joint 20 of the potion bottle. Be sure to Such a facility makes it possible to avoid the installation of the metallic capsule 23 shown in FIGS. 1 and 2.

It is also possible to allow the stopper 22 and / or the bottom 40 of the needle cap 36 to penetrate at the center thereof, which can reduce the force applied to the body of the syringe so that the needle can be You can pass through. In addition, such an installation can reduce the amount of particles released from the stopper when the needle passes through the stopper and also prevent the particles from being injected with the mixture. In practice, forcing the stopper in the inlet 18 of the potion bottle ensures the compressive stress of the material making up the stopper. The bottom 22 of the stopper 22 and / or the cap 36 provided with the through hole in advance does not leak once installed.

Also preferably, the guide component 14 is made of synthetic material, for example polypropylene, and sterilized by conventional techniques such as pressure cookers or gamma radiation.

The first embodiment of the injection device shown in FIG. 1 can be used in the following way: In a first step, the compound to be freeze-dried is provided in a potion bottle 10 in which the guide part 14 is separated. The stopper 22 is installed in the quasi-insertion position. When the freeze-drying operation is finished, the stopper 22 is fully inserted and the aluminum capsule 24 is installed. The syringe 12 containing the pre-sterilized second liquid compound is independently installed into the guide part 14 together with the protective cap 36, and then the assembly is connected to the flange of the guide part 14 and the joint of the potion bottle 10. It is fixed to the potion bottle by the interaction between the rings 20. The injection device then enters the state shown in FIG. 1 and is stored in this state. In a variant embodiment here, the syringe may first be installed in a guide part. This syringe is filled with liquid and closed with the plunger 52. This assembly is disinfected and then fixed on the potion bottle 10, which is optionally performed under a laminar steam cover.

In case of injecting a mixture of the above-freeze-dried compound 16 and the liquid 56 contained in the syringe 12, the following method is used, in which the body of the syringe is adjacent to the shoulder portion 50. It is inserted into the guiding part 14 until it is released, in which position the rubber cap 36 is deformed and the tip of the needle is penetrated by the bottom of the cap 36 and the stopper 22 of the potion bottle. Through, which is shown in the second degree. Therefore, the needle 36 allows the inside of the syringe body to communicate with the inside of the potion bottle 10. Then, the adjusting rod, which is a push rod, is mounted in the plunger 52 of the syringe 12, and the plunger is partially inserted to allow the appropriate amount of liquid 56 to pass through the potion bottle 10 so that the two compounds (16, 56) ) Mix. Here, when actually mixed in the potion bottle 10, the plunger 52 is drawn and sucked the mixture into the body 30 of the syringe located vertically. In this way, the syringe is prepared for immediate injection, and the syringe 12 can be extracted from the guide component 14. During the above operation, the cap 36 of the needle 34 is fixed on the potion bottle 10 by the guiding part 14, the needle penetrating the stopper and carrying the mixture is detachable from the syringe, optionally It may be replaced with another needle to allow injection of the mixture.

Also shown in FIG. 3 is a second embodiment of the injection device, in which in this second embodiment the potion bottle in which the freeze-dried compound 16 is to be accommodated and the stoppers 22 of the potion bottle are shown in FIG. The same will not be described again below. The same is true for the guide part 14 with the end 28 fixed on the potion bottle 10. The difference between the second embodiment is that the needle of the first embodiment is replaced with a tubular member 60 having two through ends 62, 64, which part 60 is replaced with the injection end 32 of the syringe 12. It is mounted in the guide part 14 between the stoppers 22 of the potion bottle 10. As shown in FIG. The tubular member 60 is fixed at the axial position of the guide component 14 by a radial fin member which interacts with the inner wall of the guide component 14. In addition, the injection end 32 of the syringe is provided with a permeable membrane 70 installed opposite the end 62 of the tubular member 60.

In a variant embodiment, the tubular member 60 may be provided with a double needle inserted with a filter of suitable characteristics therebetween, and the double needle may be provided on the injection end of the syringe while the guide part 14 is extracted from the syringe. It can be positioned and fixed at.

In a further alternative embodiment, a sealing member, for example a zero-ring, may be inserted between the clip portion 28 and the fixed capsule 23 of the guide component 14.

Therefore, in order to use the injection device and to mix the compounds contained in the syringe body and the potion bottle 10, respectively, the body of the syringe is inserted into the guide part 14 until it adjoins on the shoulder portion 50, and in the fourth degree. In this position, better shown, the ends 62, 64 of the tubular member 60 penetrate the central portion of the penetrating membrane 70 and the potion cap 22 of each syringe. In this position, the end faces of the radial pin member may act as a stopper of the stopper 22 and the syringe 700 of the potion bottle so that the stopper 70 and the stopper 22 effectively. In addition, the plunger 52 can be operated in the above position to discharge a portion of the liquid contained in the syringe 12. Once mixing is performed in the potion bottle 10, the plunger 52 is removed. It can be pulled and sucked into a vertically positioned syringe body, and can be operated in the same manner as described above even when working with a pre-filled trunk or a syringe provided with the trunk.

For injection here, the syringe is withdrawn from the guide component 14 and the appropriate needle is fixed on the injection end 32 of the syringe.

Also in a variant embodiment, in order to inject the mixture, the potion bottle is separated from the guide piece 14, and the guide piece 14 is firmly connected with the syringe end. To do this, a cutout portion is provided in the flange which is torn off by hand or by rotating the guide component against the potion bottle in the flange 28 for securing the guide component on the potion bottle.

In the above case, if a subcutaneous or intramuscular injection is to be placed on the patient, an additional insertion of the syringe into the guide part needs to be performed, which means that the needle end protrudes from the lower surface of the fixing flange. This protruding needle end comes into contact with the patient's skin. In order to control this injection, it is desirable to have an additional shoulder portion in the guide part, which shoulder portion 50 can enter in under the effect of syringe insertion.

On the other hand, FIG. 5 shows a third embodiment of the injection device. According to this embodiment the cap 36 of the needle is preferably replaced by a cylindrical penetrable part 14 fixed in the end of the guide part 14. The end of the needle 34 is penetrated into this penetrable part 80. The penetrable part 80 is previously penetrated like the bottom of the gap 36. On the other hand, in order to guide the needle during the insertion of the syringe into the guide part 14, the guide tube 82 is installed in the axial direction of the guide part 14 and on this guide part by a radial pin member as indicated by reference numeral 84. Guide tube 82 is firmly coupled to the provided. Also shown in this figure is an additional inner shoulder portion 85 which may limit the insertion of the syringe into the guide part 14 at the time of injection. In this case, if the potion bottle is separated from the guide part 14, the syringe Will remain coupled within the guide component.

In a variant embodiment, the side of the penetrating component 80 is compressed in such a way that the diameter of the guide component 14 surrounding the penetrating component 80 is smaller than the diameter of the main body of the guide component so that the liquid is not leaked. Tighten. This ensures a seal in the guide part 14 in addition to the sealing member 48. In addition to the part of the stopper 22 through which the needle penetrates, the penetrable part 80 is forced and flattened, so that this part of the stopper can be protected against the risk of contamination. Additionally, the pressure applied on the stopper 22 is utilized for the penetrating force of the stopper.

In the above-described second and third embodiments, all the variations described with the first embodiment can be added, in particular, the potion bottle is penetrated in advance, the guide parts are provided with protective joints, and the clip flange is used. It can be added that the stopper is fixed on the bottle, and that the inner shoulder portion is provided in the guide part so that the end of the needle is generally in the plane of the inner surface of the stopper.

In addition, the fourth embodiment of the injection device is shown in Figure 6, there is a fundamental difference from the above-described embodiments in the structure of the potion bottle 10 indicated by the reference numeral 10 'in this figure. The potion bottle 10 'is preferably provided with a cylindrical body with a bottom 92 closed by a permeable film 94 provided on its outer circumference with a groove engaging the edge 96 of the bottom of the potion bottle. 90 is provided. The second end 98 of the potion bottle is preferably also provided with a rim 100, which is closed with a stopper 102 made of a pierceable or optionally pre-penetrated material. The stopper 102 is forced into the rim 100 in the potion bottle and is coupled. The stopper 102 is also provided with, for example, a cylindrical recess 104 on its upper surface, which is provided with a screw thread 106 on its side wall, the function of which will be described below. Preferably, the outer side 107 of the stopper is provided with three ribs used for sealing together with the inner side of the potion bottle.

In addition, in this drawing, the guide part 14 indicated by reference numeral 14 ′ may be modified with respect to the guide part shown in FIGS. 1 to 5, and the outer shoulder part 110 is coupled to the coupling end 108 of the guide part. Is provided, and extends into a skirt 112 of diameter smaller than the diameter of the main part of the guide component. The skirt 112 is provided with a screw thread 114 that can be engaged with a stopper outer screw thread 106 on its outer surface. As a result, as in the case of FIG. 5, the needle end has an upper end integral with the guide tube 122, and the lower end is inserted into the penetrable part 102 lying on the bottom of the stopper 102. As shown in FIG.

Meanwhile, the method of using the injection device according to FIG. 6 is as follows.

The potion bottle 10 ′ in which the drug to be freeze-dried is accommodated therein already performs the operation described above. The guide part is fixed to the potion bottle 10 'by screwing the skirt 112 of the guide part to the inner surface of the cap 102 of the potion bottle while the syringe is filled with liquid therein. Accordingly, the shoulder portion 110 of the guide part is supported by the rim 100 of the potion bottle and screwed at the same time, the upper free end 124 of the stopper is in contact with the inner surface of the rim. Thus, the guide part is connected to the potion bottle 10 'and the stopper 102 is not moved.

The syringe 102 is then inserted into the guiding part 14 'and the end of the needle 34 penetrates the part 120 and the stopper 102 to the interior of the potion bottle 10' and the interior of the syringe 12. Ensure that is in communication. By displacing the plunger 52 of the syringe, the received liquid passes into the potion bottle 10 ', which is mixed with the freeze-dried drug.

With respect to the stopper 102 of the potion bottle 10 ′ embedded therein, the guide part 14 ′ may be released by turning a screw. The mixture is housed in a potion bottle closed with a stopper 102 whose one end is a penetrating membrane 94 and the other end acts as a plunger, for which the screw inside the stopper 102 The adjustment rod, which can act as a push rod handle, can be screwed in place.

As a result, in order to inject the patient with the mixture contained in the potion bottle 10 ', a needle with both needles is mounted in the permeable membrane 94 and gradually inserted through the stopper 102 into the potion bottle, where The plug acts as a plunger, such as the piston of a syringe.

Similarly, the potion bottle 10 'may also be used as a liquid reservoir for a pump that is connected to a tube that is connected to the potion bottle via its permeable membrane 94, in which case the stopper 102 may be When the liquid is inhaled, it is sucked into the potion bottle due to the pressure difference.

Also in the fourth embodiment, one of the functions of the screw screws 106 and 114 is that the stopper 102 is temporarily connected to the body of the potion bottle 10 'adjacent to the opening 18 thereof. ) And to be penetrated by the end of the needle of the syringe, the other is to remove the stopper 102 during movement after removal of the guide component 14 'so that the stopper can act as a plunger. It is apparent that the present injection device is not departed from the scope of the present invention even if it is provided with other means capable of performing the above two functions. For example, the stopper 102 is provided with an outer ring facing the outer periphery of the inlet of the potion bottle 10 'to prevent the stopper from being inserted into the potion bottle. After the guide piece 14 'is removed, the ring is broken to allow insertion of a stopper 102 that can act as a plunger.

It can also be seen that the embodiment of the potion bottle described in connection with FIG. 6 can be used in conjunction with the embodiment of FIG. 3 and FIG. 4, which means that the needle is provided with a tubular member 60 having penetrating ends 62, 64. Is used when it is replaced with.

7A and 7B, different embodiments of guide parts will now be described, which are indicated by reference numeral 14 " in this figure. Inside this part 14 ", they are integral with this part 14 ". Is provided with a guide component 130 and a cylindrical portion 132 for connection of the component 14 "and a cylindrical portion adapted to receive the end of the syringe body when the syringe is fully inserted into the component 14". 134 and needle guides 136 generally connected to the cylindrical portion 134 by a conical portion 138. A radial pin member 140 as shown in FIG. The pin member 140 is provided with a frame 142 which defines a hollow frame 144 in which a penetrating part 80 into which the needle end is inserted is received on the lower end thereof. The possible component 80 is firmly coupled to the guide component 130. As a result, the top of the joint 138, i.e. the guide, is The area marked 146 in the part 14 "will receive the sealing member 48.

On the other hand, as shown in FIG. 7C, when the guide part 14 "is mounted on the potion bottle, the penetrable part 80 is tightened between the stopper 22 of the potion bottle and the lower end of the guide part 136, This penetrable part thus closes the lower end of the guide 130 in a leak-free manner to prevent contamination of the penetrable central part of the stopper 22. In addition, if a syringe is installed in the guide part 14 ", The sealing member 48 ensures sealing on the other end of the guide 130. During storage of the injection device, the needle of the syringe is therefore completely protected in the guide 13. This protection lasts through all the work of mixing the two compounds.

Preferably, the syringe is installed in the guiding part and such an assembly is fixed on the potion bottle. In the case of the embodiment shown in FIGS. 7A and 7B, when the body of the syringe interacts with the sealing member 48, the interior of the part 130 is closed in a leakless manner. The air contained in the space thus formed acts against the insertion of the syringe until the syringe reaches its storage position, where the end of the needle pierces the part 80 at the storage position of the syringe. In order to allow the air to be discharged at this stage, a second needle that passes completely through part 80 and exits inside part 130 must be temporarily installed. This second needle may then be used to guide the gaseous germicidal material into the part 13. The second needle is then removed prior to securing the part 14 "on the potion bottle and the orifice that guided the needle is closed again after the needle is withdrawn.

In addition, in FIGS. 8A to 8C, a new modified embodiment of the injection device is presented. According to this embodiment, the potion bottle 10 and the syringe 12 are shown in FIGS. 1 and 2 or 5. Same as the members. Therefore, it will not be described again here.

The guide part 14 "'here comprises a cylindrical body 150, one end of which forms an adapter which is club-fixed onto the narrow part 20 of the potion bottle. Extends into the housing 156 having a joint ring 154 and adapted to receive the sealing member 158, ie preferably the sealing lip as shown in FIG. 1. As already described above, this sealing member 158 ) Ensures a seal between the syringe 12 and the guide part 14 "'during all relative movement of the syringe with respect to the guide part.

On the other hand, inside the cylindrical body 150, there is a guide structure 160 provided with a truncated conical portion 162 rigidly connected to the body 150 and extending to the distal cylindrical portion 164, where within the distal portion 164. The penetrating component 166 is made of rubber material. In addition, a cylindrical portion 164 is provided with a sleeve 168 rigidly coupled to the portion 166. And the free end of the sleeve contacts the face l66a of the penetrable part 166, and in addition, the second face 166b of the part [66] projects slightly against the free end of the cylindrical part 164. Done. Therefore, when the guide part 14 "'is fixed on the potion bottle 10, the penetrable part 166 is slightly compressed, which is the center portion of the stopper 22 to be penetrated with the face 166b of the part 166. The installation may also be provided with a penetrable component 80 or 120 shown in the embodiment of FIG. 5 or FIG.

8a shows a cylindrical body of a guide part including an orifice 170 installed on a connection area of the guide structure 160 connected to the cylindrical body 150, where the orifice 170 is a conventional type of beauty. Closed by a siege filter 172, the hydrophobic filter 172 is provided with holes of a very small size to maintain the asepticity of the volume bounded by the guide structure 160. For example, the hole in the filter has a size of 0.22 microns.

The filter 172 has two functions, one of which allows air to be discharged when the syringe is inserted into the guide component. Such a facility is highly desirable because it is provided with a sealing member 158. The other is that after the syringe is installed in the guide part 14 "', the guide part is fixed on the potion bottle to guide the sterilizing gas into the guide structure. A microporous filter similar to the filter 172 shown in FIG. It is apparent that it is mounted on the guide component 14 of FIGS. 1 to 5 and mounted on the guide component 14 ', 14 "of FIG. 6 and FIG.

8A, the needle 34 of the syringe preferably includes a needle protection member, and the needle protection member 180 is formed of a cylindrical house surrounding the needle 34. As shown in FIG. The first end 184 penetrates past the end of the needle and slightly protrudes. The other end of the needle bar 182 is provided with a removable component 186 fixed on the injection end of the body of the syringe 12. During insertion of the syringe into the guide piece 14 "', the end 184 of the needle reference member 182 is guided by the sleeve 168 of the guide structure. In its final storage position, the end 184 of the needle Partially penetrates component 166.

Preferably, the fixed part 186 includes a portion 187 made of rubber material to provide a seal between the needle and the end of the syringe with the needle protection member 180.

On the other hand, in order to mix the products as described above, a syringe is inserted into the guiding part (FIG. 8B). During this displacement, the end of the needle protection member is closed on the part 166 and the stopper 22 of the potion bottle 10. It protects the end of the needle 34 by penetrating through, and the needle protection member 182, by the nature of the material of which the protection member is constructed, stops the plug 22 when the syringe 12 is removed from the guide part 14 "'. And left by friction in the component 166. The grip of the needle protection member 182 is also attributable to the friction force between the fixing portion 186 and the guide portion 14 "'of the needle protection member, or Alternatively, it originates from a guide component of a particular shape that is clipped onto the guide.

In the embodiment as described above, the guide piece is fixed on the potion bottle by the specific shape of the end 28 of the guide piece.

According to the embodiment of FIG. 9A, at the end of the guiding part 14 "', there is a circular joint 220 which comes into contact with the outer circumference of the cap 22 of the potion bottle. Ring-shaped corrugated capsule 222 Is provided with a first inner-curved portion 224 coupled within the slot 26 of the joint ring 220 and the second cylindrical portion 228. The free end 230 of the cylindrical portion 228 is a potion bottle. It is to be crimped on the lower surface of the narrow portion of 20 is firmly connected to the guide part 14 'of the potion bottle.

9b shows a variant embodiment of the mounting on the pleated capsule 222 ′, in which the folded portion rests on the joint 220 ′ forming the first end of the guide component 14 ′ ′. 224 ', the remaining portions of this corrugated capsule 222' are the same as the capsule 222 described above.

In Fig. 9c it is shown that the guide part 14 "'shown in Fig. 9b is fixed on a potion bottle equipped with a stopper 22, which has already been removed as shown in Fig.1. The fixed portion of the potion bottle is fixed by a fixed capsule, or alternatively, the stopper 22 may simply be inserted into the inlet of the potion bottle In these two cases, the guide part with the syringe already inserted 14 "') Is fixed on the potion bottle and the joint ring 220' is in contact with the outer circumference of the stopper (22). In this way, the free end 230 'of the pleated capsule is pleated.

The solution shown in FIGS. 9A and 9C is intended to simplify the connection of the potion bottle 10 with the part and the guide part 14 "', since the pleated capsules 222, 222' are already fixed on the guide piece. It is apparent that the above connection method can be applied to the above-described embodiments by modifying the shape of the first end of the guide part.

10a to 10d, the use of an injection device with an autoinjector is shown in this figure, where the injection device is shown in FIGS. 8a to 8c except that the needle protection member is not provided. An injection device of the type shown. In addition, the clip end 152 of the guide component 14 "'is preferably extended to the joint ring 190, as will be described later, to form a contact surface.

After the two compounds have been mixed, the mixture is aspirated by a syringe as described above, the guiding part 14 "'is separated from the potion bottle 10, and the plunger 52 of the syringe 12 The injection device is then brought into a state as shown in Fig. 10A.

In the following steps shown in FIG. 10B, the injection device is fixed in the hollow 200 of the autoinjector 202, where the syringe 12 is installed along the axis XX 'of the autoinjector hollow so that the injection device is an example. For example, the interaction of the recesses 204 and 206 with the joint ring 154 will not move during the injection of the compound.

Also shown in FIG. 10C is an assembly provided as described above being positioned on the skin of a patient to inject the mixture, more precisely, the region 190 is in contact with the portion 208 of the body of the patient to be injected. The first pressing part 212 is positioned to protrude into the hollow 200 by contacting the open end 214 of the syringe body by operating the adjustment button 210. The first pressure part 212 is displaced so that the syringe is inserted into the guide part 14 "', and thus the needle 34 is inserted into the patient's body at a predetermined distance. The lunge 52 is not displaced with respect to the syringe body.

In the final operation step shown in FIG. 10d, the second pressing part 216 coaxial with the pressing part 212 is operated without the pressing part 212 moving. By displacing the second press section 216 the plunger 52 of the syringe is inserted at an adjusted rate until all the mixture is injected into the patient. In addition, preferably the operation of the adjustment button 210 operates the pressing unit 212 and the pressing unit 216 continuously.

On the other hand, if the operator handles the injection device to insert the syringe into the guide tube to penetrate the stopper of the potion bottle, there is a risk that the outer surface of the syringe body, which is the outer sealing member of the guide tube, will be contaminated by the hands during operation. . Now, however, a portion of the surface that is hatched in FIG. 8A is penetrated into the leak-free sterile chamber partitioned by the guide tube and the sealing member. Therefore, there is a risk of contamination of the chamber and the parts of the apparatus contained therein.

8a to 8c show a first embodiment of the protection means, which is provided with a cylindrical joint 220 extending beyond the outer end of the sealing member 158. The inner diameter of the cylindrical edge is smaller than the outer diameter of the syringe body, wherein the axial length 1 of the edge is the travel distance 1 'of the syringe in the guide part 14 "' at its storage position (Fig. 8A). Therefore, the hatched area 222 of the outer surface of the syringe inserted into the tube cannot be touched by the operator's hand, thus preventing the risk of contamination by the contact of this area.

11a to 11c show a second embodiment of the annular protective means, which means that the rubber sleeve is mounted on a portion of the syringe body adjacent to the end of the sealing member 158 when the syringe is mounted in the guide tube. 224. The hatched areas are therefore protected from any danger of contamination by contact or ambient air. The length 1 of the sleeve 224 is at least equal to the traveling distance 1 'of the syringe body in the guide tube. When inserted into the syringe guide tube, the sealing member is provided with an end stop of the protective sleeve 22 ', which slides against the syringe body.

The above-described annular protective means described with reference to FIGS. 8 and 11 may be applied to and used in the embodiments shown with reference to FIGS. 1 through 7 and 9.

Meanwhile, another embodiment of the injection device is shown in FIG. 12, which can protect the assembly from the risk of contamination associated with the user holding the injection body. Here, the guide part 14 "'is shaped like a truncated cone. The main part 200 is provided, and an end for fixing the potion bottle 10 and a connecting end 204 for receiving the sealing member 206 and the syringe body are provided on the inlet of the potion bottle. A joint 208 and a member 210 are provided to be secured, and the clip tab is supplemented with a crimped ring 212. Once secured, the ring 212 is inserted into a groove made in the clip tab. Guide passages are secured above the potion bottle Preferably the passageway 34 is surrounded by a circular ring 216 protruding below the joint ring 208, which ribs interact with the stopper of the potion bottle 10. To seal between the two parts.

In addition, the upper end 204 of the guide part has a wide open cylindrical shape in which an annular protective member 206 is mounted, and the sealing member is made of (butyl) rubber or plastic. In addition, the sealing member 206 is provided with a shoulder portion 218 which interacts with the bulging portion 220 of the syringe body in a liquid-free manner, allowing for a dynamic seal while allowing sliding under the propulsion effect on its outer surface. Two sealing borders 206a and 206b are provided. And on its lower end, the sealing member is preferably provided with an annular recess 222 which interacts with the clip rib 224 once the syringe is fully inserted into the guide component.

In addition, the inside of the guide part in which the needle 34 is accommodated is prevented from leaking pathogens, in particular by the sealing member 206 and the sealing rib 216. In addition, the central area of the stopper penetrated by the needle is also protected from the risk of contamination.

The method of use of the injection device shown in FIG. 12 is as follows: In the storage position as shown in FIG. 12, the sealing member 206 is in a position not to be inserted into the guide part and in the potion bottle 10. FIG. When mixing of the contained product and the liquid contained in the syringe is performed, the syringe is inserted into the guide part 14 "'so that the sealing member is closed by the interaction of the shoulder portion 218 with the joint portion 220 of the syringe body. At the insertion end of the syringe, the clip members 222, 224 are firmly engaged in interaction with the sealing member on the guide component, after the mixture is filled in the syringe, the seal is firmly engaged on the guide component. The syringe is extracted from the member.

The syringe may be leaked by the displacement of the sealing member 206 due to insertion so that the syringe portion outside the guide part in the storage position which may be contaminated by the user is not leaked inside the guide part bounded by the sealing member 206 position. It is important to know that you will be exposed to the outside.

It is preferable to install an orifice blocked by a bacterial filter in the main part of the guide part, the entirety of which is indicated by reference numeral 226. This filter allows the air to be discharged when the syringe is inserted into the guide, while maintaining the sterilization of the space in which the needle 34 is housed.

However, since the sealing member 206 is a sliding sealing member and in the inserted position after the extraction of the syringe, the overpressure is significantly reduced when the syringe is reinserted. The filter is therefore essential for this function.

Various modifications are possible without departing from the spirit of the invention, in particular in the case of withdrawing the syringe from the guiding part, it is also possible to provide a needle that is separated from the end of the syringe while being inserted into a part such as, for example, a penetrable part or a cap. It is possible.

According to a variant embodiment, the shape of the sealing member between the guide part and the syringe body can be modified to facilitate separation of the syringe from the guide part. To this end, screw screws are made on the outer surface of the sealing member, which screw screws interact with the inner screw made on the inner surface of the guide component. The inner surface of the sealing member is provided with a sealing lip. To separate the syringe from the guide component, the body of the syringe is rotated to unscrew the sealing member. Of course, other means can be used to releasably connect the sealing member on the end of the guide piece.

13 shows another embodiment of an injection device, in particular another method of sealing between a syringe body and a guide component.

The syringe body is provided with a potion bottle, in which a product, in particular a freeze-dried product, is received and closed by a penetrating stopper 22, with the guide component indicated by reference numeral 14a being fixed on the potion bottle. This guide part is provided with a truncated cone-shaped portion 230 extending to the joint ring 232 is fixed on the top of the narrow portion of the potion bottle 10 and the stopper. The other end of the truncated cone portion 230 is provided with a cylindrical portion 234 which is used herein to guide the syringe indicated at 12 '. In this specific embodiment, the syringe 12 ′ has a cylindrical glass body 238 closed at its first end by a stopper 240 and at its second end by another stopper forming a plunger 242. It is composed of a body portion 236 manufactured by a conventional method as described. The plunger 242 is to receive the end of the adjusting rod 244 of the syringe. The first end of the trunk portion 238 is fixed to the cylindrical adapter 246 rigidly connected to the trunk portion. The adapter 246 is provided with a cylindrical portion 246a and a truncated end portion 246b in which the fixed end portion 248 of the needle 34 'is screwed therein. As shown in FIG. 13, two annular ribs 250, 252 are provided on the outer surface of the cylindrical portion 246a of the adapter 246 to form a sealing lip, which protrudes from the outer wall of the adapter. These ribs are mutually engaged with the inner surface 234a of the cylindrical portion of the guide component. The two ribs or ribs 250, 252 described above are formed of a dynamic sealing member between the adapter, ie the syringe 12 'and the portion 234 of the guiding part 14a, which seal member 10 Is maintained during insertion of the syringe 12'to penetrate the stopper 22 of the < RTI ID = 0.0 > Therefore, the leads 250 and 252 form the first sealing means between the syringe body 12a 'and the guide part 14a in this embodiment.

Preferably, the head 248 of the needle 34 'is provided with a radial rib, such as 254, and inside the truncated portion 23 of the guide component, a portion indicated by reference numeral 260 is provided into the guide component. The protrusion of is formed so that when the needle is inserted to penetrate the stopper 22, the portion 260 is flush with the rib 254 of the needle 34 '. On the other hand, in order to safely detach the needle 34 'from the adapter 246, the user rotates the syringe 12' when the syringe is in the insertion position. Also, since the protruding member is inserted between the ribs 254 of the needle head, the user can automatically release the needle by the above-described rotational movement without touching it.

Therefore, even if the injection body 12 'is equipped with a conventional type syringe made of deformable plastics, it does not depart from the present invention. In this case the annular ribs 250, 252 are made directly on the outer surface of the syringe body, and also automatic means for releasing the needle are provided similarly to the above.

14A shows another embodiment of the syringe shown in FIG. 12, in which the penetrating waterproof rubber membrane 270 defines a volume 272 which does not leak into the penetrating stopper of the potion bottle 10. 200 is provided. In the storage position, the needle 34 passes through the membrane 270 in a leak-free manner, and the membrane 270 is expelled from the potion bottle with possible overpressure in the potion bottle after mixing with the temporary and local deformation of the penetrating zone. Part of the remaining liquid or gas that may be confined within volume 272. By its elasticity, the through hole of the membrane is closed as soon as the needle is withdrawn. The gas limiting chamber facility may be provided in all embodiments of the injection apparatus.

Figure 14a also shows a new embodiment of a sealing member for sealing between the upper portion 204 of the guide component and the syringe, the annular sealing member 274 is provided with an inner surface fixed on the syringe body 12 Interaction with the shoulder portion 276 of the syringe also inserts the sealing member into the syringe body. The upper portion 206 of the guide component is provided with two small elastic material protrusions projecting into the guide component. In the storage position shown in FIG. 14A, the protrusions 284 and 286 protrude between the upper lip 282 and the intermediate lip 280, thereby preventing the sealing member 274 from being accidentally detached from or inserted from the guide part. Done.

14b and 14c illustrate in more detail the method of operation of the sealing member 274 described above, which is preferably an outer seal 278, 280, 282 and syringe body in contact with the inner surface of the guide component. Two inner lips 279 and 281 are provided in contact with the. In its storage position (FIG. 14A), the sealing member is in the upper position, and the protrusion is coupled between the upper lip 282 and the middle lip 280. These protrusions 284 and 286 act as non-releasable end stops to allow the sealing member 274 to be inserted but not to escape.

In this position, the intermediate lip 280 and the lower lip 278 are sealed, and the protrusions 284 and 286 interact with the intermediate 280 to prevent the sealing member 284 from accidentally exiting the guide component. Do not

When the syringe is inserted to penetrate the stopper of the potion bottle, the sealing member 284 is moved along the syringe body, and the upper lip 282 causes a temporary deformation of the protrusion so that the lip passes through the bottom of the protrusion. The protrusion prevents displacement of the sealing member while the syringe is withdrawn from the guide component by the non-releasable function. Therefore, the sealing member is in the inserted position.

FIG. 15 shows another embodiment that limits the harmful gases that can be emitted from the potion bottle, the present embodiment having a porosity such as a porous foam at the end of the truncated portion of the guide part 14 "'. It is constructed by installing a component 300 made of material, and when the needle is pulled out of the bottle, gas which may leak from the bottle is absorbed, blocked or trapped by the component 300. Of course, the component ( 300 is passed by the needle 34.

16A and 16B show two different embodiments of gas limiting chambers, wherein the lower end of the conical part of the guide component is connected to the housing 302 connected to the guide component by a passage 304 having a diameter substantially the same as the diameter of the needle. Is extended. The wall of the housing 302 is terminated by a free end 306 that fits snugly on the stopper 22 of the potion bottle. This results in a generally leaking chamber, which also limits the possible gas leaking out of the potion bottle.

On the other hand, in the case where the mixture to be inserted produces a large amount of gas, the wall of the housing 302 is a porous filter that purifies the harmful portion of the gas while balancing the overpressure associated with purifying the gas leaking out of the housing. 308).

FIG. 17 illustrates another method for recovering gas that may leak from the potion bottle while the needle is being pulled out. The conical portion 200 of the guide part 14 "'has a porous filter 310 in which gas is controlled and removed. The sealing member 312 including the inner and outer sealing lip between the syringe body and the guiding part is provided so that the guiding part 14 " It is held in the guide part only by the upper shoulder part 314 which prevents it from going out, and the side wall of the guide part is itself waterproof. Therefore, during the entire extraction process of the syringe, the inside of the guide part is not leaked by the interaction of the sealing member 312 and the syringe. As a result, the gas has time to escape through the filter 310, so that the overpressure of the gas in the guide part is balanced while purifying the harmful gas by the filter 310.

After mixing the compounds, the operator must withdraw the syringe from the guide part, because of the nature of the material constituting the guide part, a high frictional force can be applied. As a result, the operator releases the syringe by applying an arbitrary force on the syringe against the guide part. During this process, the needle may pierce the operator's hand holding the guide part by the operator moving at an inappropriate time. According to an improved embodiment of the syringe to avoid the above mentioned risks, the extraction of the syringe is carried out in two operations: firstly the syringe is partially pulled out, overcoming the resistance, in particular friction, from the guide component, and then after the specific treatment operation. Is to release the syringe completely from the guide without applying high traction. In order to achieve this result, the final extraction is only possible by rotating the syringe with respect to the guide part, so a mechanical end stop must be provided to limit the extraction of the syringe in the first step of the extraction process.

18A and 18, the above-described equipment in the same case as in the embodiment of FIG. 14 is shown, but it is obvious that the injection apparatus can be easily replaced by a different embodiment.

As shown in FIG. 8A, the end 320 of the syringe is provided with a small compartment 322, which is a spiral notch 324 provided on the inner surface of the sealing member 274. Are combined within. The end 326 of this notch 324 is buried into the upper end of the sealing member; The other end was not buried. This notch 324 corresponds to a 90 degree rotation, for example, and the internal notch does not break the seal provided to the sealing member 274. In addition, the notch 322 protruding out of the guide part is not moved during rotation by interacting with the recess 334 of the sealing member. During mixing mixing of the product in the storage position, the notch 322 is blind of the notch. With end 320. When the user exerts a traction on the syringe, frictional force is triggered so that the syringe is firmly connected to the sealing member 274 and the guide component. Only when the syringe is rotated at an angle of 90 degrees with respect to the guiding part is the notch 322 completely drawn out towards the open end 326 of the notch. The extraction is performed without applying any high force and the operator's movement can be fully controlled.

Of course, another solution is conceivable in which the discharge of the syringe is separated into two operations by the rotation of the syringe.

As already mentioned above, the injection device preferably consists of a syringe with a guide part and a potion bottle with a penetrating stopper, even if provided as a syringe and a bottle with a guide part, respectively, without departing from the scope of the present invention, These two elements are in turn tightly connected to form a complete assembly. In this case, during the storage period the first end of the guide part must be closed in a leak-free manner to ensure the sterility of the needle. Another solution is to sterilize the end of the syringe with the guide and the needle immediately after mounting on the potion bottle.

Those skilled in the art will understand the sealing member between the syringe and the guide component, which seal member is mounted between the two members and on the syringe on the other hand the guide member on the other hand. It consists of a sealing bellows. The deformation of the bellows absorbs the displacement of the syringe and the guide component during the mixing process.

Claims (48)

At least the first compound is an injection device that allows the mixing of two compounds that are liquids, comprising a syringe 12 having a body with an injection end 32 and containing the first compound, wherein Syringe, A part which guides the injection end of a syringe during the movement of the syringe between a first position, called the draw-out storage position, and a second position, called the inserted operating position, the inner surface of which a bottle of compound is contained. The first and second ends, including a first end projecting opposite the pierceable area of the closure which closes the inlet in a leaky manner, and second ends 46 and 204 for receiving the injection end of the syringe. A cylindrical guide means 14, 14 ', 14 "', 14" "provided with sealing means and means for providing a sufficient connection between said syringe and said second end; Communicating means (34, 60) of the syringe for penetrating the pierceable area of the stopper when the injection end of the syringe is moved to the second position and for allowing the interior volume of the syringe to communicate with the interior of the bottle In the injection device comprising: The sealing means includes an annular seal 48, 108, 222, 222 'installed in the guide means (guiding part), wherein the seal has an inner surface fixed to the cylindrical body of the syringe and the cylindrical guide means. An outer surface contacting the inner surface to form at least one deformable seal lip, the seal being capable of providing a seal in the storage position during relative movement of the two portions between the body of the syringe and the inner surface of the guide means. And the communicating means is arranged along the axis of the cylindrical sea of the cylindrical guide means and the syringe. 2. The injection device of claim 1, wherein the injection device comprises a potion bottle with a stopper, connecting the first end of the guide means (guide component) to the inlet 18 of the potion bottles 10, 10 '. Injecting device for mixing two compounds characterized in that the connection means for further provided (28, 108, 222, 222 '). The injection device according to claim 2, wherein the potion bottle (10) is provided with a bottom portion. 4. The connecting means 28 for connecting the guide means 14 to the potion bottle further comprises an attachment means not leaking on the outer circumference of the potion bottle stopper 22. An injection device for mixing two compounds. The method of claim 1, wherein the connecting means (28, 222, 222 ') is crushable so that the potion bottle (10) can be separated from the guide parts (14, 14', 14 ", 14" '). An injection device for mixing two kinds of compounds. 4. A pleated capsule (222, 222 ') mounted on the first end (220, 220') of the guide means (14 "'), wherein said connecting means is provided. An injection device for mixing two compounds characterized in that they can be crimped into a joint (20) at the inlet of the potion bottle (10) while holding the guide means on the potion bottle as a fixing means. 4. The injection device according to claim 3, wherein the fixing means is provided with a clip tab for interacting with the outer circumference of the potion inlet. The method of claim 1, wherein the communication means comprises a needle (34) mounted on the injection end of the syringe, the end of the needle passing through the central portion of the stopper (22) when the end of the syringe is placed in the second position. An injection device for mixing two kinds of compounds, characterized in that. The injection end 32 of the syringe 12 according to claim 1, wherein the communication means has one end 64 closing the central portion of the stopper 22, the other end of which is the injection end 32 of the syringe 12 when the syringe is in the second position. An injection device for mixing two compounds, characterized in that it comprises a tubular member (60) capable of penetrating the permeable membrane (70) made on the). 10. The injection device according to claim 9, wherein the tubular member is composed of two needles having a filter disposed therebetween. 9. A cap 36 according to claim 8, further comprising a cap 36 surrounding the needle 34, the one end of which allows the end of the needle to penetrate when the syringe is in the second position. An injection device for mixing two compounds. 12. The cap (36) according to claim 11, wherein the cap (36) is made of a deformable elastic material and, when the injection end (32) of the syringe is in the first position, the cap extends over the entire length of the needle. An injection device for mixing two kinds of compounds. 9. The device according to claim 8, further comprising a penetrating part (80, 120) integral with said guide means (14), wherein the end of said needle (34) is inserted into the part (80, 120). An injection apparatus for mixing two kinds of compounds. 14. An injection device as claimed in claim 13, wherein said penetrating component (80, 120) is perforated. 14. The surface of the component as set forth in claim 13, wherein said penetrating component is made of elastic material and the potion bottle is adapted to act on the stopper, provided with respect to said guide means, said penetrating member when said guide component is fixed on the potion bottle. An injection device for mixing two compounds, characterized in that the possible parts are installed to be compressed. 9. The compound according to claim 8, further comprising an axial guide tube (82) which is integral with the guide means (14) surrounding the needle when the syringe is fixed to the guide means. Injector mixing. A first internal shoulder portion (49) for limiting the insertion of a syringe body into the guide means (14) such that the end of the needle does not penetrate the stopper (22) in the storage position. Injector for mixing two compounds characterized in that the provided. 2. The syringe body according to claim 1, wherein when the guide means is in the second position, the end of the communication means (34, 60) in the second position is positioned substantially in the plane of the inner surface of the stopper (22). An injection device for mixing two compounds, characterized in that the guide means is further provided for limiting the insertion of the compound (50). 6. The method according to claim 5, wherein after the connecting means is crushed to remove the potion bottle 10, the first end of the guiding means forms a support area for insertion and the guide means over the support area in the guiding means. 14) An injection device for mixing two compounds characterized in that the inner shoulder portion (85) for restricting the insertion of the syringe into the protruding end so that the end of the needle protrudes from the support area. 2. The injection device of claim 1, wherein the potion bottle (10 ') has a permeable membrane (94) on an opposite end of its inlet (18). 21. The device according to claim 20, characterized in that the stopper (102) is mounted in a leak-proof manner into the potion bottle and means for temporarily connecting the potion bottle in close proximity to the inlet 18 of the potion bottle. An injection device for mixing two kinds of compounds. 22. The temporary connecting means according to claim 21, wherein said temporary connecting means has a first screw thread (106) made in a stopper (102), said first screw screw being made on the connecting end (108) of said guide component (14 '). Injection device for mixing two compounds characterized in that the interaction with the second screw thread (114). 2. An injection device according to claim 1, wherein said stopper (22, 102) is perforated. The method of claim 8, wherein the guide means (14, 14 ') is provided with two projections (51, 154) that is provided externally to protect the finger from the needle when the guide means is fixed Injector for mixing the compound. The injection device of claim 1, wherein the sealing member forms a ring, and at least two sealing lip portions are provided on a surface of the ring interacting with the syringe body. The injection device of claim 1, wherein the sealing member is made of an elastomer. The injection device of claim 1, wherein the sealing member is made of plastic. The method of claim 1, wherein the sealing member is provided with a temporary means for moving connection with the syringe body when the syringe moves between the first position and the second position Injector. 29. The method of claim 28, wherein the temporary connecting means is provided with a shoulder formed on the face of the sealing member which interacts with the protrusion of the body of the syringe so that the seal can be moved as the syringe body is inserted. An injection device for mixing two compounds. 30. The injection device of claim 29, wherein the interacting means seals between the sealing member and the syringe body. 29. The injection device of claim 28, wherein the sealing member includes a first locking member that can interact with the second locking member when placed in the second position. 29. An injection device as claimed in claim 28, wherein at least two sealing lip portions are provided on a sealing member surface which interacts with the guide component. 2. The sealing device according to claim 1, wherein the first sealing means 274 has an annular ring shaped sealing member connected to the syringe so as to move in the insertion direction during the movement of the syringe, the ring having guide means 14 " " Sealing lip portions 278, 280, and 282 interacting with an inner surface of the guide component, the guide part being provided with retractable protrusions 284 and 286, which can interact with the lip portion on its inner surface, An injection device for mixing two compounds, characterized in that the sealing member is prevented from being separated from the guide component. An annular ring (312) is provided in connection with the syringe in the insertion direction during movement of the syringe, the ring having a seal lip on its inner and outer surfaces, wherein said guide component (14 "") An injection device for mixing two compounds, characterized in that the shoulder portion 314 is included to prevent the sealing member from being separated from the guide component. 34. The method of claim 33, wherein the ring is provided with three sealing lip portion, in the storage position the mixing of the two compounds characterized in that the projection is installed between the outermost lip portion 282 and the intermediate lip portion 280 Injector. The method according to claim 1, wherein the second sealing means for pressing the communication means together with the first sealing means in the guide means is further provided with a mixture of the two compounds, characterized in that provided in the guide means Injector. 37. An injection device as claimed in claim 36, wherein said second sealing means covers a stopper (22) of said potion bottle to be penetrated by a communication means. 38. The potion ring of claim 37, further comprising a joint ring contacting the inlet of the potion bottle at the first end of the guide means, wherein the joint ring is a means for securing the potion bottle. Injection device for mixing the two compounds characterized in that the protrusion annular portion is provided so as not to interact with the stopper. The injection device of claim 1, wherein the first sealing means (250, 252) is formed integrally with the syringe body. 40. The apparatus of claim 39, wherein the syringe body is made of plastic and the first sealing means comprises at least one annular lip protruding from the syringe body and interacting with an inner surface of the guide means. Injector for mixing the compound. 40. A syringe according to claim 39, wherein the syringe has a body portion 236 extending to a plastic adapter 246 to mount a needle 34 'on its end, the adapter having at least one annular rib on its outer surface. And 250, 252, which interact with the inner surface of the guiding means 14a, wherein the rib constitutes the first sealing means. 42. A radial according to claim 41, wherein the needle (34 ') is screwed onto the adapter (246) and the head (248) of the needle interacts with a portion (260) forming a protrusion into the guide component (14a). Rib 254 is provided, the injection device for mixing the two compounds characterized in that the screwing of the needle (34 ') relative to the adapter (246) by the rotation of the syringe body (12'). 12. The membrane skin according to claim 1, wherein the inside of said guide means (14, 14 ', 14 "', 14" ") is permeable, elastic, and water resistant between the first and second ends of the guide means. 270 is installed and the communication means passes through the membrane when the device is in the storage position so that the area located between the membrane 270 and the stopper can collect a leaking gas from the potion bottle. An injection device for mixing two kinds of compounds, characterized in that forming. The injection device according to claim 1, wherein the guide means further comprises an orifice blocked by a porous filter between the first end and the second end. 2. The guide component (14 "") is provided with a component (300) made of porous material adjacent to its first end, the component being passed through a needle (34) while the needle is therefrom. An injection device for mixing two compounds characterized in that it can absorb the leakable gas from the potion bottle during the extraction. The housing of claim 1, wherein the first end of the guide component (14 "") is extended by a housing (302) connected into the guide component by a passage (304) through which a needle (34) passes, and the housing is free. An injection device for mixing two compounds, characterized in that the stage (306) is joined to the opposite end of the stopper (22) of the potion bottle and the housing forms a chamber to hold the gas leaking out of the potion bottle. 9. The needle protection member (180) of claim 8 is further provided with a needle protection member (180) removably mounted around the needle, the needle protection member having a through end extending over the end of the needle, the through end having a potion bottle. An injection device for mixing two compounds, characterized in that the plug can be penetrated. 48. The needle protection member 180 according to claim 47, wherein the needle protection member 180 has a portion 187 made of an elastic material on its fixed end so as to interact with the end of the syringe on which the needle is mounted. Injection device for mixing a compound of a species.