KR100218093B1 - Germicide composition from yucca extract for animal - Google Patents

Abstract

The present invention relates to a yucca extract-containing animal disinfectant composition.

More specifically, the present invention relates to an animal disinfectant composition comprising a combination of an existing disinfectant, didexyl dimethyl ammonium chloride, and a natural yucca extract, and has an excellent penetration effect in organic matter and an excellent effect of removing odors in a barn compared to existing animal disinfectants. .

Description

Yucca extract-containing animal disinfectant composition

The present invention relates to a yucca extract-containing animal disinfectant composition.

More specifically, the present invention relates to an animal disinfectant composition comprising a combination of the existing animal disinfectant, didecyl dimethyl ammonium chloride, and Cheonan Yucca extract, which is superior to the conventional disinfectant in penetrating into organic matters and removing odors in the barn. .

In order to raise livestock such as cattle, pigs, and chickens in a healthy way and maximize their production capacity, it is necessary to create a pleasant environment free of disease.

However, when looking at the domestic livestock environment, the disease is widespread due to collective breeding and Dadu desire.

The main cause of these diseases is due to microorganisms such as bacteria, viruses, and fungi.

Therefore, disinfectants are used to remove pathogens that propagate in farms. These disinfectants are germicides that kill microorganisms harmful to livestock and reduce the risk of disease infection.

Currently used animal disinfectants include phenolic compound disinfectants, halogenated compound disinfectants, aldehyde compound disinfectants, and quaternary ammonium compound disinfectants.

Phenolic compound disinfectant is cresol, phenol or olsodichlorobenzene as disinfectant. Cresol or phenol is effective only for bacteria and has little disinfecting ability against apobacteria and viruses. It has bactericidal power against bacteria, fungi, protozoa, and eggs, and has little effect on viruses, and is also very weak to light, so the disinfection effect decreases quickly in the sun and the penetrability in organic matter is weak.

Halogenated disinfectants are used as disinfectants such as sodium hypochlorite, stabilized chlorine dioxide, and iodine compounds. Most halogen compounds disinfect their proteins by modifying the protein of the pathogen by the strong oxidizing ability. Disinfectant has disinfecting power against a wide range of microorganisms such as bacteria, viruses, apoptoses, fungi, algae, etc., but the disinfecting power against encapsulating virus is weak, and disinfecting power is greatly decreased when the temperature rises. It is not suitable for disinfection inside the house because it loses the weight.

Aldehyde disinfectants are used as a disinfectant, such as formaldehyde, glyoxal, glutaraldehyde, etc., and show a wide range of disinfecting powers such as bacteria, viruses, and protozoans. Formaldehyde has strong toxicity and low disinfection in molds and organics. There is, glutaraldehyde is superior to formaldehyde disinfectant, but has the disadvantage of showing toxicity to the human body, such as skin or eyes.

Quaternary ammonium disinfectants include quaternary ammonium compounds such as benzalkonium chloride, methyldodecyl benzyltrimethyl ammonium chloride, methyldodecylene trimethyl ammonium chloride, octyldecyldimethyl ammonium chloride, and didecyl dimethyl ammonium chloride. Positive soap) is used and has a wide range of disinfecting power such as bacteria, viruses, fungi, protozoa, algae, etc., but in hard water containing calcium ions, magnesium ions, iron ions, etc. The quaternary ammonium compound-based disinfectant has a weak penetrating effect on the organic matter of the farm, so that the disinfection effect in the presence of organic matter or protein is reduced, and there is no problem in removing odors such as ammonia gas or hydrogen sulfide gas already generated in the farm.

In other words, the conventional disinfectant and disinfection mechanism of the disinfectant, when disinfectant is sprayed on the farm, the disinfectant particles come into contact with the pathogen microorganisms to destroy the cell membrane of the microorganisms or cause denaturation of the cell protein, thereby exhibiting disinfecting power.

At this time, the contaminated hospital microorganisms inhabit mainly organic matters such as feces, urine, feed residues, oils, etc., because organic matters are good habitats for hospital microorganisms.

These pathogenic microorganisms generate harmful gases such as ammonia gas and hydrogen sulfide gas while growing in organic matter.

Therefore, the conventional disinfectant does not strongly kill the pathogenic microorganisms inhabiting in the organic matter because of the weak penetration force in the organic matter and there is a problem that can not remove the harmful gas already generated.

Therefore, the present inventors have studied intensively to solve the above problems, and as a result of the complex composition of the yucca extract which exhibits the organic substance decomposition promoting substance and the odor removing effect, the penetration effect and the odor removing effect of the disinfecting component, which is a weak point of the conventional disinfectant, are The present invention was completed by discovering that it can be improved.

That is, an object of the present invention is to provide a disinfectant pharmaceutical composition for animals excellent in the sterilization effect of the pathogenic microorganisms, excellent in the resulting decay removal effect by improving the penetration effect of the pharmaceutical components in the organic substance by complex composition of the yucca extract.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

Yucca extracts are natural substances extracted from a plant similar to Yucca schidigera, which is mainly found in the Americas, and contains more than 10% of sarsaponine, its main active ingredient.

Yucca extract has been widely used as a foaming agent for beverages since 1965 without any restrictions in the human body field.In the livestock sector, the deodorant of barns, the promotion of decomposition of fecal organic matter, the reduction of flies in farms, It has been used for various purposes such as growth promotion and feed efficiency improvement.

The antiseptic drug composition for animals according to the present invention contains 1-20% by weight of yucca extract as described above.

That is, the present invention is a composite composition of any one compound selected from a phenol compound, a halogen compound, an aldehyde compound or a quaternary ammonium compound which is a conventional pharmaceutical ingredient and a yucca extract.

The content of the phenol compound, halogen compound, aldehyde compound or quaternary ammonium compound is not particularly limited but from a clinical point of view 2-20% by weight of quaternary ammonium compound, 1-20% by weight of aldehyde compound, halogenated compound 2- It is preferable that 2 weight% or 30-90 weight% of phenol compounds are contained, and it is preferable that 2-20 weight% of quaternary ammonium compounds are contained especially.

As the quaternary ammonium compound, Didecyl dimethy1 ammonium chloride (hereinafter referred to as DDAC) is suitable. In other words, the yucca extract-containing animal disinfectant composition according to the present invention is preferably made of a composite composition of 1-20% by weight Yucca extract and 2-20% by weight of DDAC.

When the content of the yucca extract is less than 1% by weight, the infiltration effect in organic matters is insignificant, so that the sterilization effect of microorganisms is reduced and the harmful gas removal effect is insignificant. Although excellent, there is a disadvantage in that the stability is reduced by causing a separation phenomenon in the melting process after freezing.

In addition, when the content of DDAC is less than 2% by weight, the sterilization effect is weak, and when it exceeds 20% by weight, the sterilization effect is excellent, but due to the irritating odor, there is a concern that the disinfectant's health may be damaged when disinfectant is sprayed.

Hereinafter, the mechanism of action of the antiseptic drug composition according to the present invention will be described.

Yucca extract promotes the decomposition of various organic matters, and the sarsaponin component in the yucca extract combines with the odorous gas to remove odors. Also, DDAC is a cationic surfactant that emulsifies, penetrates, washes, disperses and bubbles. It has the characteristics and bactericidal action, and when it is dissolved in water, it has (+) electricity, so it is easily accessible to the pathogen carrying (-) electricity, and it destroys the pathogen by destroying the cell wall of the pathogen or denaturing the cytoplasm.

The disinfectant composition according to the present invention containing the yucca extract and DDAC which act as described above is more easily accessible to the pathogen by virtue of the strong Brownian motion and the electric attraction force of the disinfectant particles composed of the combined yucca extract and the DDAC. It penetrates and dissociates the lipoprotein complex of the cell wall and at the same time increases the permeability of the cell membrane, penetrates into the cytoplasm to cause denaturation of proteins and nucleic acids in the cytoplasm and promotes the activation of self-free enzymes, thereby purin, pyrimidine-containing substances and free amino acids and peptides. Flows out of the cell wall and kills the pathogen, and when the organic material surrounds the pathogen, the organic material layer covering the pathogen is first peeled off by the washing component of the disinfectant particles composed of the yucca extract and the DDAC. The disinfectant component of the disinfectant particles It strongly approaches the pathogens that carry (-) electricity and kills them, and the odor removal component (Yuka extract) is combined with the ammonia gas (NH ₃ ) or hydrogen sulfide gas (H ₂ S) produced by the decayed bacteria. binding) to remove odors.

Hereinafter, the present invention will be described in more detail with reference to Examples.

However, the present invention is not limited by the examples described below.

Example 1

0.5 weight of sodium gluconate and 0.085 weight percent of sodium citrate were added and dissolved in an appropriate amount of purified water, and stirred for about 5 minutes. Then, 10 weight% of ethanol and 5 weight% of DDAC were added and stirred for another 5 minutes.

To this, 0.5 wt% of yucca extract was added and stirred for about 15 minutes, then an appropriate amount of perfume was added. Purified water was added so that the total amount was 100% by weight, and stirred for about 15 minutes to prepare an animal disinfectant.

Example 2

An animal disinfectant was prepared in the same manner as in Example 1, except that 1 wt% of yucca extract was added.

Example 3

An animal disinfectant was prepared in the same manner as in Example 1 except that 5 wt% of yucca extract was added.

Example 4

An animal disinfectant was prepared in the same manner as in Example 1, except that 10 wt% of the yucca extract was added.

Example 5

An animal disinfectant was prepared in the same manner as in Example 1 except that 20 wt% of the yucca extract was added.

Example 6

An animal disinfectant was prepared in the same manner as in Example 1, except that 30 wt% of yucca extract was added.

Comparative Example 1

0.5 weight sodium gluconate and 0.085 weight percent sodium citrate are dissolved in an appropriate amount of purified water, stirred for about 5 minutes, 10 weight percent ethanol and 5 weight percent DDAC are added and stirred for another 5 minutes. Purified water was added to the amount of 100% by weight and stirred for about 15 minutes to prepare an animal disinfectant.

[Evaluation Example]

In order to evaluate the disinfecting effect of the animal disinfectant composition prepared by the above-described Examples and Comparative Examples, the antimicrobial activity for each composition was measured and compared.

Antibacterial activity measurement method

E. coli ATCC 25922 was inoculated on the medium and incubated at 37 ° C. for 24 hours. Then, the test piece was placed in the center of the medium, and the stock solution and 10% dilution solution of each of the animal disinfectants prepared in Examples and Comparative Examples were used as a test solution. The stock solution was diluted with distilled water and diluted to a 10% concentration), and each test piece was inoculated with 50 m each, followed by incubation at 37 ° C for 24 hours.

After completion of the culture, the diameter (D) of the sample and the diameter (T) of the bacterial lowland in which growth of bacteria on the medium were suppressed were measured, and the size (W) of the bacterial lowland was calculated by Equation 1 below. The results are shown in Table 1. In the results of Table 1, the larger the size (W) of the bacterium, the better the antibacterial activity.

In other words, the larger the size (W) of the bacteriophage, the better the sterilizing power.

In Equation 1, W denotes the width of the bacterial stop (mm), T denotes the diameter of the bacterial stop where the growth of bacteria on the medium is suppressed (mm), and D denotes the diameter of the sample (mm).

As can be seen from the results of Table 1, Example 1 is not preferable because there is no improvement in disinfection power compared to Comparative Example 1 which is a conventional animal disinfectant.

As described above, the yucca extract-containing animal disinfectant composition according to the present invention contains the yucca extract, thereby improving the penetration effect of the disinfectant in the organic matter as compared to the conventional disinfectant, and has excellent sterilization effect, and the odor removal effect in the barn is improved. In addition, by reducing the irritating odor of the existing disinfectant has a health effect of the disinfectant.

Claims (2)

An animal disinfectant composition comprising a compound selected from a phenol compound, a halogen compound, an aldehyde compound or a quaternary ammonium compound as a pharmaceutical ingredient, wherein the animal disinfectant composition contains 1-20% by weight of yucca extract. The method of claim 1, wherein the pharmaceutical ingredient is a disinfectant composition for animals, characterized in that the composite composition of 2-20% by weight of the dexyl dimethyl ammonium chloride and 1-20% by weight of the yucca extract is a quaternary ammonium compound.