KR0149389B1 - Herb composition for curing constipation - Google Patents

Herb composition for curing constipation Download PDF

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KR0149389B1
KR0149389B1 KR1019950004607A KR19950004607A KR0149389B1 KR 0149389 B1 KR0149389 B1 KR 0149389B1 KR 1019950004607 A KR1019950004607 A KR 1019950004607A KR 19950004607 A KR19950004607 A KR 19950004607A KR 0149389 B1 KR0149389 B1 KR 0149389B1
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tangerine peel
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한난수
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Abstract

본 발명은 기미, 주근깨 및 여드름의 피부결함과 변비 치료에 효과가 있는 생약성분 조성물에 관한 것으로, 물 269중량부에 대하여 말린귤껍질 3~20중량부를 첨지하여 귤껍질의 유효성분 추출액을 만들고, 상기 귤껍질 유효성분 추출액 240~280중량부에 대하여 인삼 20~30중량부, 오미자 2~5중량부, 백반 80~120중량부, 감초 150~250중량부, 살구씨 1~3중량부, 구기자 2~6중량부를 첨가하고 가열하여 상기 생약성분이 추출되도록 하여 제조되며 기미, 주근깨, 여드금 및 변비치료 효과가 크면서도 인체에 대한 안정성이 크고 피부도포방법과 경구투여 방법을 병핼할 수 있어 효과적으로 소기의 치료할 수 있다.The present invention relates to a herbal composition that is effective in treating skin defects and constipation of blemishes, freckles and acne, by adding 3 to 20 parts by weight of dried tangerine peel to 269 parts by weight of water to make an active ingredient extract of tangerine peel, 20-30 parts by weight of ginseng, 2-5 parts by weight of Schisandra chinensis, 80-5 parts by weight of alum, 150-250 parts by weight of licorice, 1-3 parts by weight of apricot seed, wolfberry It is prepared by adding 2 to 6 parts by weight and heating to extract the herbal ingredients, and the effect of treating blemishes, freckles, acne and constipation is high, and the stability to the human body is large, and the skin application method and oral administration method can be effectively combined. The desired treatment is possible.

Description

변비 치료용 생약성분 조성물Herbal composition for treating constipation

본 발명은 기미, 주근깨, 여드름등의 피부결합을 방지 및 치료하고 변비치료에 효과가 있는 생약성분 조성물에 관한 것이다.The present invention relates to a herbal composition that is effective in preventing and treating skin bonds such as blemishes, freckles, acne, and constipation treatment.

기미와 주근깨는 노출된 피부에서 빈번하게 발생하는데 이들의 원인이 되는 멜라닌은 그 생성반응이 산화반응로서 피부세포에 활성산소가 존재하면 순식산에 형성된다.Freckles and freckles frequently occur in exposed skin, and their melanin is formed in pure acid when active oxygen is present in skin cells.

때문에 상기 및 주근깨 치료방법으로서 비타민 C, 비타민 E 로써 활성산소가 슈퍼옥사이드(O2 -), 히드록실라디칼(·OH), 싱글렛 옥시전(·O2)등을 제거하는 것이 시행되어 왔다.Therefore, as a treatment method for the freckles and freckles, active oxygen has been removed as superoxide (O 2 − ), hydroxyl radical (· OH), singlet oxygen (· O 2 ), and the like as vitamin C and vitamin E.

한편 여드름은 체내에서 순환하는 호르몬인 안드로겐이 증가하여 모지선(毛脂繕)의 크기와 활동을 증가시키는 사춘기때 주로 시작되는 것으로 안드로겐, 특히 테스토스테론과 디히드로테스토 스테론이 축적된 결과라는 사실이 잘 정립되어 있다.Acne, on the other hand, begins mainly during puberty, when the androgen, a hormone circulating in the body, increases the size and activity of the gland, which is a result of the accumulation of androgens, especially testosterone and dehydrotestosterone. It is established.

디히드로테스토스테론(DHT)은 테스토스테론이 피부에서 대사되어 생기는 것으로서(Bensolet al, 미국특허 제4,088,760호) 테스토스테론보다 4~20배 강력한 안드로겐이다.Dehydrotestosterone (DHT) is an androgen that is 4-20 times more potent than testosterone as it is produced by metabolism of testosterone in the skin (Bensolet al, US Pat. No. 4,088,760).

그러나 안드로겐이 DHT로 변환되는 것이나 이들이 피부에 축적되는 정확한 메카니즘에 관해서는 아직까지 연구가 계속된다.However, research is still ongoing on the conversion of androgens to DHT and the exact mechanism by which they accumulate in the skin.

본 발명자는 기미, 주근깨와 여드롬의 치료제 개발을 위해 오랜기간 연구를 거듭한 결과 한방에서 오래전부터 쓰여오던 생약성분을 취사선택하여 상기한 질환의 치료에 가장적합한 조성물을 안출하기에 이르렀는데 본 발명에 따른 조성물은 인체에 대한 충분한 안정성이 있으면서 사용방법에 있어서도 피부도포 방법은 물론 경구투여 방법도 병행할 수 있어서 피부 결함을 보다 효과적으로 치료할 수 있게 하고 더 나아가 이 조성물이 경구투여된 경우 비정상적인 장(腸)의 기능을 회복시켜서 변비치료에도 효과를 보인다.The present inventors have conducted a long-term study for the development of a medicament for blemishes, freckles and acne as a result of the selection of herbal medicines that have been used for a long time in oriental medicine to come up with the most suitable composition for the treatment of the above-mentioned diseases. The composition according to the present invention has sufficient stability to the human body and can be combined with the skin application method as well as the oral method in the method of use, so that the skin defect can be more effectively treated, and furthermore, when the composition is orally administered, the abnormal intestine ) To restore the function of constipation treatment is effective.

본 발명자는 다수의 생약제를 조합한 다양한 조성물들을 만든후, 이들의 기미, 주근깨 및 여드름에 대한 효과를 비교 검토하였는데 가장 바람직한 조성물은 진피, 인삼, 오미자, 백반, 감초, 살구씨, 구기자의 추출물을 포함한 조성물이었다.The present inventors made various compositions combining a number of herbal medicines, and compared their effects on blemishes, freckles and acne. The most preferred compositions are extracts of dermis, ginseng, Schisandra chinensis, alum, licorice, apricot seed and wolfberry. It was a composition included.

상기 생약성분들로 이루어진 조성물을 제조하기 위해서는 먼저 말린 귤껍질을 물에 넣어 그 유효성분을 추출하고 ; 이 추출액에 인삼, 오미자, 백반, 감초, 살구씨와 구기자를 투입하고 가열하여 생약성분 추출물을 농축, 건조 및 분쇄하여 분말화 할 수도 있고 필요에 따라 상기 분말화된 생약성분 추출물을 피부에 도포하기 적당한 형태 또는 경구투여에 적합한 형태로 만들 수도 있다.In order to prepare the composition consisting of the herbal ingredients, first put the dried tangerine peel in water to extract the active ingredient; Ginseng, Schisandra chinensis, Alum, Licorice, Apricot Seed and Goji berries may be added to the extract and heated to concentrate, dry and pulverize the herbal extracts. It may be made in a suitable form or in a form suitable for oral administration.

이하 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.

먼저 상기 생약성분 조성물의 제조방법에서 쓰이는 유효 생약성분들의 작용을 설명하면, 말린 귤껍질은 한방에서 진피라고 불리우는 약재로서, 이것을 우려낸 액은 여타 생약성분간의 효과를 증개시키고 이들 생약성분들이 혼합된 조성물의 부패를 억제하여 보존성을 증대시키는 하편 건위(健胃), 발한(撥汗)의 약효가 있다.First, when explaining the action of the active herbal ingredients used in the preparation method of the herbal composition, dried tangerine peel is a medicine called the dermis in one shot, the solution that concerns this is to increase the effect between the other herbal ingredients and the composition of these herbal ingredients Inhibit the decay of the lower side to increase the preservation health (健胃), sweating (撥 汗) has the effect.

인삼은 오래전 부터 강장약, 강정약, 보혈약으로 많이 써왔는데, 인삼을 물에 우린액은 중축신경계통 특히 고위중추 신경계통 부위에 작용하여 적은양에서는 흥분시켜서 많은 양에서는 흥분시켰다가 억제시키고, 또한 외부의 해로운 자극에 대한 유기체의 방어능력(저항성)을 향상시킨다.Ginseng has long been used as a tonic, gangjeong, and blood donation drugs. Ginseng in water acts on the central nervous system, especially in the central nervous system. It also improves the organism's ability to resist external harmful stimuli.

오미자는 중추신경계에 대해서 오래동안 지속되는 흥분작용이 있으며 반사흥분성을 높이고 또한 근육 신경의 흥분성을 높이면 말초신경 계통의 기능을 좋게한다.Schisandra chinensis has a long-lasting excitatory effect on the central nervous system and increases reflex excitability and also increases the excitability of muscle nerves to improve the function of the peripheral nervous system.

백반은 소독작용과 함께 상기한 물질로 부터 약효성분을 추출해내고 이들이 서로 혼합되어 세포내로 흡수가 잘되도록 하는 역할을 한다.The alum serves to disinfect and extract the active ingredients from the above-mentioned substances and mix them with each other to ensure good absorption into the cells.

감초는 한의학에서는 여러가지 약제와 배합되어 조화와 상호조절작용을 하기때문에 자주 사용되는 것으로, 독성물질을 제거하는 해독효과가 있고, 다른 생약성분의 조성물과 혼합되어 약효를 증진시키면서 체내에 축적된 유해한 물질을 배출하여 세포를 보호하고, 약제나 유해물질로 부터 조직의 손실을 최소화되게 한다.Licorice is often used in oriental medicine because it combines with various medicines to act in harmony and mutual control, and it has a detoxifying effect to remove toxic substances, and it is mixed with other herbal ingredients to improve the efficacy of the harmful substances accumulated in the body. To protect the cells and to minimize tissue loss from drugs and harmful substances.

구기자는 혈압을 내리는 작용이 있다고 알려졌고 열매를 오래먹으면 복용자의 뼈를 튼튼하게 하고 몸을 가볍게 하며 흰머리를 검게하고 눈을 밝게하며 추위와 더위를 타지않고 오래산다는 말이 전해오고 있다.It is known that goji berries have the effect of lowering blood pressure, and eating fruit for a long time has strengthened the bones of the taker, lightens the body, darkens the gray hair, brightens the eyes, and keeps them free from cold and heat.

살구씨는 한방에서는 행인(杏仁)이라고 하는데 호흡기 질환이나 변비에 쓰이며 피부의 상피세포를 정상적으로 보전하는데 필수요소인 비타민 A 를 다량 함유하고 있다.Apricot seeds are called algae (杏仁) in oriental medicine, used for respiratory diseases and constipation, and contains a large amount of vitamin A, which is essential for the normal preservation of epithelial cells of the skin.

이하 본 발명을 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail.

귤껍질 성분 추출액을 만들기 위해서는 물 260중량부에 대하여 말린 귤껍질을 3~20중량부로 침지하는데 유효성분이 신속한 추출을 위하여는 가온하는 것이 바람직하다.To make the tangerine peel component extract, immerse the dried tangerine peel to 3 to 20 parts by weight with respect to 260 parts by weight of water, but the active ingredient is preferably warmed for rapid extraction.

상기 귤껍질 성분 추출액에는 생약성분을 첨가하는데, 상기 귤껍질 유효성분 추출액 240~280중량부에 대하여 인삼 20~30중량부, 오미자 2~5중량부, 백반 80~120중량부, 감초 150~250중량부, 살구씨 1-~3중량부, 구기자 2~6중량부를 넣고 가열한다.To the tangerine peel component extract is added a herbal ingredient, 20 to 30 parts by weight of ginseng, 2 to 5 parts by weight, Schisandra chinensis 2 to 5 parts by weight, alum 80 to 120 parts by weight, licorice 150 to 250 per 240 to 280 parts by weight of the tangerine peel component extract Part by weight, 1 to 3 parts by weight of apricot seed, and 2 to 6 parts by weight of wolfberry are heated.

본 발명에 따라 제조된 생약성분 조성물은 용액, 점제, 에멀젼, 분말등의 형태로 피부도포용 또는 경구투용으로 사용할수 있는데 특히 경구투여를 용이하게 하기위해 상기 생약성분 추출물을 건조, 분말화한후 캡슐화할 수도 있다.The herbal composition prepared according to the present invention can be used for skin application or oral administration in the form of a solution, a viscous, an emulsion, a powder, etc. In particular, after drying and powdering the herbal ingredient extract to facilitate oral administration You can also encapsulate.

[실시예 1 : 유효한 생약성분의 추출]Example 1 Extraction of Effective Herbal Ingredients

물 260중량부에 말린 귤껍질 5g을 넣고 가열하여 귤껍질을 우려낸 용액 250g을 만들었다.5 g of dried tangerine peel was added to 260 parts by weight of water to make 250 g of a solution in which the tangerine peel was soaked.

이 용액속에 인삼 20g, 오미자 3g, 백반 100g, 감초 200g, 기계적으로 분쇄한 살구씨 2g, 구기자 3g을 넣고 1시간 동안 가열하여 유효 생약성분을 추출한 후 300메쉬 여과포로 여과하여 고형물질을 제거하였다.20 g of ginseng, 3 g of Schisandra chinensis, 100 g of alum, 100 g of licorice, 200 g of mechanically pulverized apricot seed and 3 g of wolfberry were added and heated for 1 hour to extract the active herbal ingredients and filtered through a 300 mesh filter cloth to remove solids.

[실시예 2 : 생약성분 조성물의 캡슐화]Example 2 Encapsulation of Herbal Medicine Composition

실시예 1에서 애과포로 여과한 유효 생약성분 용액을 증발농축, 건조, 분쇄하여 분말화된 생약성분 추출물을 얻고 이들 통상의 제약적 방법에 따라 캡슐화 하였다.In Example 1, the effective herbal ingredient solution filtered with a follicle was evaporated, dried, and ground to obtain a powdered herbal ingredient extract, which was encapsulated according to these conventional pharmaceutical methods.

[사용예 1 : 피부결합 치료제로서의 생약성분 조성물의 사용][Use Example 1: Use of herbal ingredient composition as skin binding agent]

안면에 기미가 있는 각각 50세, 65세인 여성2인에 대하여 상기 실시예 1에서 제조된 조성물의 약효를 실험하였다.The efficacy of the composition prepared in Example 1 was tested for two women 50 and 65 years old, each with a blemish on the face.

대상여성들을 매일 취침저에 먼저 세안을 한 후 안면에 상기 조성물을 적량도포한 후 취침하였다.The women were first washed on the bed every day, and then, after applying a suitable amount of the composition on the face, they went to bed.

25~30일이 지나자 안면에 있던 기미가 깨끗하게 없어지는 것을 물론 피부가 윤택하여 졌다.After 25 to 30 days, the spots on the face disappeared cleanly, and the skin became lustrous.

[사용예 2 : 여드름 치료제로서의 생약성분 조성물의 사용][Use Example 2: Use of herbal composition as acne treatment]

안면에 심한 여드름 증세가 있는 17~12세 사이의 남녀 각 2명씩에 대하여 상기 실시예 1에서 제조된 생약성분 조성물 용액을 하루 2회씩 매회마다 2g정도로 안면에 골고루 도포하였다.For each two men and women between 17 and 12 years of age with severe acne symptoms on the face, the herbal composition composition prepared in Example 1 was evenly applied to the face at about 2g each time twice a day.

5~10일이 지나자 실험된 모든 사람이 현저한 여드름 치료효과를 보였다.After 5-10 days, everyone tested had a significant acne treatment.

[사용예 3 : 변비 치료제로서의 생약성분 조성물의 사용][Use Example 3: Use of herbal composition as therapeutic agent for constipation]

지속적인 변비증세를 보이고 있는 각각 35, 47, 58세인 여성3인에 대하여 상기 실시예 2 에서 제조된 생약성분 조성물 캡슐을 하루에 아침, 저녁 2회씩 경구 투여 하였더니 변비증세가 현저하게 완화되었다.Constipation symptoms were remarkably alleviated by oral administration of the herbal composition capsules prepared in Example 2 twice daily and evening for three women aged 35, 47, and 58 each with persistent constipation.

Claims (2)

물 260중량부에 대하여 말린귤껍질을 3~20중량부로 침지하여 귤껍질의 휴효성분 추출액을 만들고, 상기 귤껍질 유효성분 추출액 240~280중량부에 대하여 인삼 20~30중량부, 오미자 2~5중량부, 백반 80~120중량부, 감초 150~250중량부, 살구씨 1-~3중량부 및 구기자 2~6중량부를 첨가하고 가열하여 각 생약성분이 추출되도록 하여 제조된 기미, 주근깨, 여드름 및 변비치료용의 생약성분 조성물.Dried tangerine peel to 3 to 20 parts by weight with respect to 260 parts by weight of water to make the active ingredient extract of tangerine peel, 20 to 30 parts by weight of ginseng, 240 ~ 280 parts by weight of the tangerine peel active ingredient extract, Schisandra chinensis 2 ~ 5 parts by weight, alum, 80-120 parts by weight, licorice 150-250 parts by weight, 1--3 parts by weight of apricot seeds, and 2-6 parts by weight of goji berry, and then heated to extract each herbal ingredient, blemishes, freckles, Herbal ingredient composition for the treatment of acne and constipation. 제1항에 있어서, 상기 각 생약성분이 추출된 것을 농축, 건조한 후 분쇄하여 분말화하고 이를 캡슐로 만든 생약성분 조성물.The herbal composition according to claim 1, wherein the extracted herbal ingredients are concentrated, dried and ground to be powdered and made into capsules.
KR1019950004607A 1995-03-07 1995-03-07 Herb composition for curing constipation KR0149389B1 (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
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KR20010000342A (en) * 2000-09-18 2001-01-05 박증국 Chinese herb medicine composition and pharmaceutical preparation thereof
KR20020001931A (en) * 2000-06-20 2002-01-09 임병철 The cosmetic product containing phellodendri cortex extract and/or schizandrae fructus extract which have anti-acne activity
WO2004052387A1 (en) * 2002-12-12 2004-06-24 Kt & G Corporation Crude drug compositions and the process for preparing them
KR100506824B1 (en) * 2002-12-12 2005-08-11 주식회사 케이티앤지 Crude Drug Compositions for treating or preventing intestinal disease and constipation
KR20170116922A (en) 2016-04-12 2017-10-20 정대진 Crude drug composition for improvement of constipation and manufacturing method
KR20220167129A (en) 2021-06-11 2022-12-20 주식회사 비욘드푸드 Health assistance food composition showing the effect of promoting bowel movement and diet and intake method of the composition

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KR100376307B1 (en) * 2000-08-07 2003-03-17 한완석 Healthy food composition for preventing and treatmenting constipation
KR100584153B1 (en) * 2002-07-25 2006-05-29 서울향료(주) Manufacture method, Various uses and Extracts for The Development of Anticonspitation Functional food materials from Oriental Herbal Medicines
KR100821631B1 (en) * 2002-08-17 2008-04-16 (주)아모레퍼시픽 A beauty food composition containing oriental medicine extract for improvement of skin condition
KR101034180B1 (en) * 2008-05-09 2011-06-20 김영복 Skin cosmetic composition containing lycii fructus extract

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020001931A (en) * 2000-06-20 2002-01-09 임병철 The cosmetic product containing phellodendri cortex extract and/or schizandrae fructus extract which have anti-acne activity
KR20010000342A (en) * 2000-09-18 2001-01-05 박증국 Chinese herb medicine composition and pharmaceutical preparation thereof
WO2004052387A1 (en) * 2002-12-12 2004-06-24 Kt & G Corporation Crude drug compositions and the process for preparing them
KR100506824B1 (en) * 2002-12-12 2005-08-11 주식회사 케이티앤지 Crude Drug Compositions for treating or preventing intestinal disease and constipation
KR20170116922A (en) 2016-04-12 2017-10-20 정대진 Crude drug composition for improvement of constipation and manufacturing method
KR20220167129A (en) 2021-06-11 2022-12-20 주식회사 비욘드푸드 Health assistance food composition showing the effect of promoting bowel movement and diet and intake method of the composition

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