JPWO2021231461A5

JPWO2021231461A5 -

Info

Publication number: JPWO2021231461A5
Application number: JP2022569455A
Authority: JP
Publication date: 2024-05-22

Claims

1. A device for delivering a fluid, comprising:
a housing including a connector configured to be fluidly coupled to a drug- loaded ocular viscoelastic device;
a fillable reservoir for storing a fluid;
a cannula including a proximal end, a distal end and a lumen, the proximal end of the cannula being coupled to the distal end of the housing, the distal end of the cannula being configured to enter a patient's eye through a corneal incision, the lumen of the cannula extending from the proximal end to the distal end of the cannula;
a catheter including a proximal end, a distal end and a lumen, the proximal end of the catheter being fluidly coupled to the reservoir, the lumen extending from the proximal end of the catheter to the distal end of the catheter;
a first actuator configured to, upon actuation, advance the catheter along a lumen of the cannula and cause the catheter to exit through a distal end of the cannula;
a second actuator configured to, when actuated, cause fluid stored in the reservoir to flow through the catheter and exit through a distal end of the catheter;
Including,
the catheter lumen is configured to allow fluid stored in the reservoir to flow through the catheter and into the patient's eye;
the catheter is sized to extend out of the distal end of the cannula and around a full 360° circumference of Schlemm's canal of the patient upon actuation of a first actuator;
the first actuator is movable relative to the second actuator such that dispensing of fluid stored in the reservoir is decoupled from movement of the catheter.
Device.

The device of claim 1, wherein the distal end of the cannula includes a spatula having a sharp tip.

The device of claim 1 or 2, wherein the distal end of the cannula is pre-curved.

The device according to any one of claims 1 to 3, wherein at least a distal portion of the catheter is preformed to approximately follow the radius of curvature of Schlemm's canal.

The device according to any one of claims 1 to 4, wherein at least a distal portion of the catheter is flexible.

The device of any one of claims 1 to 5, wherein the cannula comprises a rigid material.

The device of any one of claims 1 to 6, wherein the distal end of the cannula includes a notch and two or more anchors.

The device according to any one of claims 1 to 7, wherein the first actuator and the second actuator are configured to be operable by one hand of the user.

the housing further comprises a channel;
the first actuator includes a first sliding trigger adapted to move axially within the channel between a proximal position and a distal position;
the second actuator includes a second sliding trigger adapted to move axially within the channel between a proximal position and a distal position.
An apparatus according to any one of claims 1 to 8.

when the first sliding trigger is in the proximal position, the distal end of the catheter is located between the proximal and distal ends of the cannula;
when the first sliding trigger is in the distal position, a distal end of the catheter advances past a distal end of the cannula;
Movement of the second sliding trigger between the proximal and distal positions causes a predetermined amount of fluid to be dispensed through the distal end of the catheter.
10. The apparatus of claim 9.

The device of claim 9, wherein the amount of axial movement of the second sliding trigger along the channel corresponds to the amount of fluid dispensed from the catheter.

10. The device of claim 9, wherein the catheter is positioned and sized such that when the first actuator is retracted to its proximal-most position within the channel , a distal end of the catheter is aligned with a distal end of the cannula.

1. A device for delivering a fluid , comprising:
a housing including a proximal connector , the proximal connector configured to be fluidly coupled to a drug-loaded ocular viscoelastic device;
a reservoir configured to store a fluid; and
a cannula configured to be inserted through a corneal incision into Schlemm's canal, the cannula including a lumen;
a catheter including a proximal end, a distal end and a lumen, the proximal end fluidly coupled to the reservoir, the distal end configured to pass past the distal end of the cannula, and the lumen configured to allow fluid stored in the reservoir to flow through the catheter and be dispensed through the distal end of the catheter;
a first slidable trigger configured to move between an inactivated position and an activated position to cause the catheter to advance along the lumen of the cannula and past the distal end of the cannula;
a second slidable trigger configured to move between an inactivated position and an activated position to cause fluid stored in the reservoir to be dispensed through a lumen of the catheter and into Schlemm's canal;
An apparatus comprising:

1. A device for delivering a fluid , comprising:
a reservoir configured to store a fluid;
a cannula including a lumen configured to enter the patient's eye through a corneal incision;
a catheter including a proximal end and a distal end, the catheter configured to advance along a lumen of the cannula, the catheter including a lumen configured to allow fluid stored in the reservoir to be dispensed through the catheter;
A first actuator;
A second actuator; and
Including,
Actuation of the first actuator causes the catheter to advance along the cannula;
actuation of the second actuator causes the fluid to be dispensed from the reservoir through the catheter;
actuation of the first actuator and actuation of the second actuator are operable independently of one another such that dispensing of fluid from the reservoir is decoupled from advancement of the catheter.
Device.

the second actuator is configured to slide between an unactuated position and an actuated position to cause the fluid to be dispensed ;
the amount of fluid dispensed is based at least in part on the distance between the non-actuated position and the actuated position;
15. The apparatus of claim 14.

16. The apparatus of claim 14 or 15, wherein the distal end of the catheter includes a bulbous distal tip.

The device according to any one of claims 14 to 16, wherein at least a portion of the catheter includes a phosphorescent colorant.

The device of any one of claims 14 to 17, wherein at least a portion of the catheter includes contrast marks spaced along the length of the catheter.

The device according to any one of claims 14 to 18, wherein at least the distal end of the cannula is constructed of a shape memory material.

The device of any one of claims 14 to 19, wherein at least the distal end of the cannula includes a notch to facilitate multi-joint deformation of the distal end of the cannula.