JPWO2021163481A5 - - Google Patents

Info

Publication number

JPWO2021163481A5

JPWO2021163481A5 JP2022549070A JP2022549070A JPWO2021163481A5 JP WO2021163481 A5 JPWO2021163481 A5 JP WO2021163481A5 JP 2022549070 A JP2022549070 A JP 2022549070A JP 2022549070 A JP2022549070 A JP 2022549070A JP WO2021163481 A5 JPWO2021163481 A5 JP WO2021163481A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

polypeptide

seq

nanoparticle

Prior art date

2024-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 42
• 108090000765 processed proteins & peptides Proteins 0.000 claims 39
• 239000002105 nanoparticle Substances 0.000 claims 38
• 102000004196 processed proteins & peptides Human genes 0.000 claims 38
• 229920001184 polypeptide Polymers 0.000 claims 37
• 230000035772 mutation Effects 0.000 claims 18
• 102000039446 nucleic acids Human genes 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 11
• 150000007523 nucleic acids Chemical class 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 10
• 239000013604 expression vector Substances 0.000 claims 8
• 102000037865 fusion proteins Human genes 0.000 claims 8
• 108020001507 fusion proteins Proteins 0.000 claims 8
• 239000000427 antigen Substances 0.000 claims 6
• 102000036639 antigens Human genes 0.000 claims 6
• 108091007433 antigens Proteins 0.000 claims 6
• 241000342334 Human metapneumovirus Species 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 229960005486 vaccine Drugs 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 102220086690 rs864622230 Human genes 0.000 claims 4
• 238000006467 substitution reaction Methods 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 3
• 230000002163 immunogen Effects 0.000 claims 3
• 239000013638 trimer Substances 0.000 claims 3
• 102220493139 6-phosphogluconate dehydrogenase, decarboxylating_F32Y_mutation Human genes 0.000 claims 2
• 102220553631 CBY1-interacting BAR domain-containing protein 1_K27N_mutation Human genes 0.000 claims 2
• 102220526139 Dihydrofolate reductase_F32R_mutation Human genes 0.000 claims 2
• 102220570669 E3 ubiquitin-protein ligase MYLIP_S20D_mutation Human genes 0.000 claims 2
• 102220487542 Phospholipase A and acyltransferase 1_L33D_mutation Human genes 0.000 claims 2
• 102220471536 Replication factor C subunit 4_R17D_mutation Human genes 0.000 claims 2
• 241000700605 Viruses Species 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102220157709 rs144942998 Human genes 0.000 claims 2
• 102220306159 rs185266383 Human genes 0.000 claims 2
• 102200147810 rs200670692 Human genes 0.000 claims 2
• 102200124760 rs587777729 Human genes 0.000 claims 2
• 102220261975 rs73749738 Human genes 0.000 claims 2
• 102220076188 rs751198815 Human genes 0.000 claims 2
• 230000003248 secreting effect Effects 0.000 claims 2
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 239000013527 degreasing agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1